[{"id":"ENSMUSP00000107795","abundance":58100,"rank":0,"name":"Tmsb4x","annotation":"Hematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization."},{"id":"ENSMUSP00000113942","abundance":18185,"rank":1,"name":"Gapdh","annotation":"Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubu [...] "},{"id":"ENSMUSP00000148326","abundance":17016,"rank":2,"name":"Gm10358","annotation":"Glyceraldehyde-3-phosphate dehydrogenase."},{"id":"ENSMUSP00000138396","abundance":15620,"rank":3,"name":"Gm3839","annotation":"Glyceraldehyde-3-phosphate dehydrogenase."},{"id":"ENSMUSP00000041652","abundance":14427,"rank":4,"name":"Rpl21","annotation":"60S ribosomal protein L21; Component of the large ribosomal subunit."},{"id":"ENSMUSP00000117987","abundance":8848,"rank":5,"name":"Ppia","annotation":"Peptidyl-prolyl cis-trans isomerase A, N-terminally processed; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding."},{"id":"ENSMUSP00000139065","abundance":8221,"rank":6,"name":"Gm15294","annotation":"Predicted gene 15294."},{"id":"ENSMUSP00000109337","abundance":7053,"rank":7,"name":"Tpm1","annotation":"Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments."},{"id":"ENSMUSP00000124509","abundance":6778,"rank":8,"name":"H3f3a","annotation":"H3.3 histone A."},{"id":"ENSMUSP00000102062","abundance":6778,"rank":9,"name":"H3f3b","annotation":"Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] "},{"id":"ENSMUSP00000110886","abundance":6398,"rank":10,"name":"Rpl39","annotation":"60S ribosomal protein L39; Belongs to the eukaryotic ribosomal protein eL39 family."},{"id":"ENSMUSP00000141419","abundance":6080,"rank":11,"name":"Gm8797","annotation":"Predicted pseudogene 8797."},{"id":"ENSMUSP00000099541","abundance":5826,"rank":12,"name":"Rpl23a","annotation":"60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family."},{"id":"ENSMUSP00000138955","abundance":5651,"rank":13,"name":"Gm12728","annotation":"Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family."},{"id":"ENSMUSP00000086852","abundance":5293,"rank":14,"name":"Gm11808","annotation":"Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be in [...] "},{"id":"ENSMUSP00000120096","abundance":5293,"rank":15,"name":"Uba52","annotation":"Ubiquitin A-52 residue ribosomal protein fusion product 1."},{"id":"ENSMUSP00000113978","abundance":4960,"rank":16,"name":"Tpm3","annotation":"Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments."},{"id":"ENSMUSP00000099962","abundance":4957,"rank":17,"name":"Rpl7a","annotation":"60S ribosomal protein L7a."},{"id":"ENSMUSP00000071486","abundance":4931,"rank":18,"name":"Actg1","annotation":"Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells."},{"id":"ENSMUSP00000019514","abundance":4847,"rank":19,"name":"Calm3","annotation":"Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2."},{"id":"ENSMUSP00000048857","abundance":4847,"rank":20,"name":"Calm2","annotation":"Calmodulin 2."},{"id":"ENSMUSP00000098066","abundance":4821,"rank":21,"name":"Actb","annotation":"Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA."},{"id":"ENSMUSP00000151305","abundance":4642,"rank":22,"name":"Rps12","annotation":"40S ribosomal protein S12."},{"id":"ENSMUSP00000074994","abundance":4485,"rank":23,"name":"H3c7","annotation":"Histone H3.2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000089346","abundance":4485,"rank":24,"name":"H3c3","annotation":"H3 clustered histone 3."},{"id":"ENSMUSP00000100739","abundance":4485,"rank":25,"name":"H3c6","annotation":"H3 clustered histone 6."},{"id":"ENSMUSP00000135215","abundance":4485,"rank":26,"name":"H3c15","annotation":"H3 clustered histone 15."},{"id":"ENSMUSP00000089295","abundance":4485,"rank":27,"name":"H3c2","annotation":"H3 clustered histone 2."},{"id":"ENSMUSP00000100737","abundance":4485,"rank":28,"name":"H3c4","annotation":"H3 clustered histone 4."},{"id":"ENSMUSP00000134751","abundance":4485,"rank":29,"name":"H3c14","annotation":"H3 clustered histone 14."},{"id":"ENSMUSP00000096442","abundance":4485,"rank":30,"name":"H3c13","annotation":"H3 clustered histone 13."},{"id":"ENSMUSP00000078239","abundance":4341,"rank":31,"name":"H2bc8","annotation":"H2B clustered histone 8."},{"id":"ENSMUSP00000061247","abundance":4341,"rank":32,"name":"H2bc6","annotation":"H2B clustered histone 6."},{"id":"ENSMUSP00000018246","abundance":4341,"rank":33,"name":"H2bc4","annotation":"Histone H2B type 1-C/E/G; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000153277","abundance":4307,"rank":34,"name":"H2bc9","annotation":"Histone H2B type 1-H; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000153457","abundance":4303,"rank":35,"name":"H2bc14","annotation":"Histone H2B type 1-M; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000135427","abundance":4284,"rank":36,"name":"H2bc18","annotation":"Histone H2B type 2-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000089301","abundance":4269,"rank":37,"name":"H2bc15","annotation":"Histone H2B type 1-F/J/L; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000100738","abundance":4269,"rank":38,"name":"H2bc7","annotation":"H2B clustered histone 7."},{"id":"ENSMUSP00000106082","abundance":4269,"rank":39,"name":"H2bc11","annotation":"H2B clustered histone 11."},{"id":"ENSMUSP00000089350","abundance":4269,"rank":40,"name":"H2bc13","annotation":"H2B clustered histone 13."},{"id":"ENSMUSP00000106085","abundance":4228,"rank":41,"name":"H2bc12","annotation":"Histone H2B type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000097294","abundance":4197,"rank":42,"name":"H2bc3","annotation":"Histone H2B type 1-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000117461","abundance":4135,"rank":43,"name":"Rpl12","annotation":"60S ribosomal protein L12; Binds directly to 26S ribosomal RNA."},{"id":"ENSMUSP00000029515","abundance":4118,"rank":44,"name":"S100a11","annotation":"Protein S100-A11; Facilitates the differentiation and the cornification of keratinocytes."},{"id":"ENSMUSP00000106099","abundance":4094,"rank":45,"name":"Hist1h2bp","annotation":"Histone H2B type 1-P; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000072197","abundance":4093,"rank":46,"name":"Tpm3-rs7","annotation":"Tropomyosin 3, related sequence 7; Belongs to the tropomyosin family."},{"id":"ENSMUSP00000136792","abundance":4076,"rank":47,"name":"Hist1h2br","annotation":"Histone cluster 1 H2br."},{"id":"ENSMUSP00000089343","abundance":4076,"rank":48,"name":"Hist1h2bq","annotation":"Histone H2B; Belongs to the histone H2B family."},{"id":"ENSMUSP00000080302","abundance":3967,"rank":49,"name":"Pgk1","annotation":"Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility."},{"id":"ENSMUSP00000079163","abundance":3965,"rank":50,"name":"Rpl15","annotation":"60S ribosomal protein L15; Belongs to the eukaryotic ribosomal protein eL15 family."},{"id":"ENSMUSP00000136357","abundance":3895,"rank":51,"name":"H4f16","annotation":"H4 histone 16."},{"id":"ENSMUSP00000100033","abundance":3895,"rank":52,"name":"H4c4","annotation":"H4 clustered histone 4."},{"id":"ENSMUSP00000100546","abundance":3895,"rank":53,"name":"Hist1h4m","annotation":"Histone cluster 1, H4m."},{"id":"ENSMUSP00000100037","abundance":3895,"rank":54,"name":"H4c8","annotation":"H4 clustered histone 8."},{"id":"ENSMUSP00000085006","abundance":3895,"rank":55,"name":"H4c11","annotation":"Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000100048","abundance":3895,"rank":56,"name":"H4c12","annotation":"H4 clustered histone 12."},{"id":"ENSMUSP00000100044","abundance":3895,"rank":57,"name":"Hist1h4n","annotation":"Histone cluster 1, H4n."},{"id":"ENSMUSP00000100032","abundance":3895,"rank":58,"name":"H4c3","annotation":"H4 clustered histone 3."},{"id":"ENSMUSP00000100030","abundance":3895,"rank":59,"name":"H4c2","annotation":"H4 clustered histone 2."},{"id":"ENSMUSP00000100029","abundance":3895,"rank":60,"name":"H4c1","annotation":"H4 clustered histone 1."},{"id":"ENSMUSP00000129930","abundance":3895,"rank":61,"name":"H4c14","annotation":"H4 clustered histone 14."},{"id":"ENSMUSP00000100042","abundance":3895,"rank":62,"name":"H4c9","annotation":"H4 clustered histone 9."},{"id":"ENSMUSP00000100036","abundance":3895,"rank":63,"name":"H4c6","annotation":"H4 clustered histone 6."},{"id":"ENSMUSP00000076397","abundance":3784,"rank":64,"name":"H2bu2","annotation":"Histone H2B type 3-A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000088287","abundance":3766,"rank":65,"name":"H2bc21","annotation":"Histone H2B type 2-E; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000099909","abundance":3695,"rank":66,"name":"Rps27a","annotation":"Ubiquitin-40S ribosomal protein S27a; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be i [...] "},{"id":"ENSMUSP00000072858","abundance":3536,"rank":67,"name":"H2ac21","annotation":"Histone H2A type 2-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000082682","abundance":3536,"rank":68,"name":"Hmgb1","annotation":"High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] "},{"id":"ENSMUSP00000099757","abundance":3526,"rank":69,"name":"Rps8","annotation":"40S ribosomal protein S8; Belongs to the eukaryotic ribosomal protein eS8 family."},{"id":"ENSMUSP00000100581","abundance":3524,"rank":70,"name":"H2ac19","annotation":"H2A clustered histone 19."},{"id":"ENSMUSP00000077814","abundance":3524,"rank":71,"name":"H2ac18","annotation":"Histone H2A type 2-A; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000088288","abundance":3521,"rank":72,"name":"H2ac20","annotation":"Histone H2A type 2-C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000138634","abundance":3500,"rank":73,"name":"Gapdhs","annotation":"Glyceraldehyde-3-phosphate dehydrogenase, testis-specific; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility."},{"id":"ENSMUSP00000104188","abundance":3407,"rank":74,"name":"Eno3","annotation":"Beta-enolase; Appears to have a function in striated muscle development and regeneration."},{"id":"ENSMUSP00000158788","abundance":3372,"rank":75,"name":"Calm1","annotation":"Calmodulin-1; Belongs to the calmodulin family."},{"id":"ENSMUSP00000139663","abundance":3203,"rank":76,"name":"H3c11","annotation":"H3 clustered histone 11."},{"id":"ENSMUSP00000079670","abundance":3203,"rank":77,"name":"H3c8","annotation":"Histone H3.1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000140394","abundance":3203,"rank":78,"name":"H3c10","annotation":"H3 clustered histone 10."},{"id":"ENSMUSP00000089293","abundance":3203,"rank":79,"name":"H3c1","annotation":"H3 clustered histone 1."},{"id":"ENSMUSP00000087453","abundance":3197,"rank":80,"name":"Hnrnpa2b1","annotation":"Heterogeneous nuclear ribonucleoproteins A2/B1; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs. Forms hnRNP particles with at least 20 other different hnRNP and he [...] "},{"id":"ENSMUSP00000104068","abundance":3172,"rank":81,"name":"Rps19","annotation":"40S ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits; Belongs to the eukaryotic ribosomal protein eS19 family."},{"id":"ENSMUSP00000103546","abundance":3161,"rank":82,"name":"Tpm2","annotation":"Tropomyosin beta chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. Belongs to the tropomyosin family."},{"id":"ENSMUSP00000104445","abundance":2968,"rank":83,"name":"H2aw","annotation":"Histone H2A type 3; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000088285","abundance":2967,"rank":84,"name":"H2ac13","annotation":"H2A clustered histone 13."},{"id":"ENSMUSP00000089345","abundance":2967,"rank":85,"name":"Hist1h2an","annotation":"Histone cluster 1, H2an."},{"id":"ENSMUSP00000080088","abundance":2967,"rank":86,"name":"Hist1h2ap","annotation":"Histone cluster 1, H2ap."},{"id":"ENSMUSP00000100034","abundance":2967,"rank":87,"name":"H2ac8","annotation":"H2A clustered histone 8."},{"id":"ENSMUSP00000072989","abundance":2967,"rank":88,"name":"H2ac10","annotation":"Histone H2A type 1-F; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000127684","abundance":2967,"rank":89,"name":"H2ac6","annotation":"H2A clustered histone 6."},{"id":"ENSMUSP00000089335","abundance":2967,"rank":90,"name":"H2ac11","annotation":"H2A clustered histone 11."},{"id":"ENSMUSP00000077477","abundance":2967,"rank":91,"name":"H2ac4","annotation":"Histone H2A type 1-B; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000089336","abundance":2967,"rank":92,"name":"H2ac12","annotation":"H2A clustered histone 12."},{"id":"ENSMUSP00000089339","abundance":2967,"rank":93,"name":"Hist1h2ao","annotation":"Histone cluster 1, H2ao."},{"id":"ENSMUSP00000088281","abundance":2967,"rank":94,"name":"H2ac7","annotation":"H2A clustered histone 7."},{"id":"ENSMUSP00000110728","abundance":2964,"rank":95,"name":"Rpl35a","annotation":"60S ribosomal protein L35a; Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site."},{"id":"ENSMUSP00000074310","abundance":2964,"rank":96,"name":"H2ac15","annotation":"Histone H2A type 1-K; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000051432","abundance":2907,"rank":97,"name":"H2ax","annotation":"Histone H2AX; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low dos [...] "},{"id":"ENSMUSP00000074142","abundance":2906,"rank":98,"name":"H2aj","annotation":"Histone H2A.J; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000022894","abundance":2866,"rank":99,"name":"Ywhaz","annotation":"14-3-3 protein zeta/delta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (By similarity). In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity)."},{"id":"ENSMUSP00000102209","abundance":2795,"rank":100,"name":"Rpl38","annotation":"60S ribosomal protein L38; Belongs to the eukaryotic ribosomal protein eL38 family."},{"id":"ENSMUSP00000047008","abundance":2622,"rank":101,"name":"Eif5a","annotation":"Eukaryotic translation initiation factor 5A-1; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an import [...] "},{"id":"ENSMUSP00000000756","abundance":2603,"rank":102,"name":"Rpl13","annotation":"60S ribosomal protein L13; Belongs to the eukaryotic ribosomal protein eL13 family."},{"id":"ENSMUSP00000117834","abundance":2475,"rank":103,"name":"Rpl29","annotation":"60S ribosomal protein L29; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL29 family."},{"id":"ENSMUSP00000023269","abundance":2466,"rank":104,"name":"Rpl24","annotation":"60S ribosomal protein L24; Belongs to the eukaryotic ribosomal protein eL24 family."},{"id":"ENSMUSP00000106014","abundance":2435,"rank":105,"name":"Rpl30","annotation":"60S ribosomal protein L30; Belongs to the eukaryotic ribosomal protein eL30 family."},{"id":"ENSMUSP00000015800","abundance":2425,"rank":106,"name":"Hspa8","annotation":"Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] "},{"id":"ENSMUSP00000075067","abundance":2400,"rank":107,"name":"Npm1","annotation":"Nucleophosmin; Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. M [...] "},{"id":"ENSMUSP00000092502","abundance":2293,"rank":108,"name":"Rps2","annotation":"40S ribosomal protein S2; Belongs to the universal ribosomal protein uS5 family."},{"id":"ENSMUSP00000011896","abundance":2247,"rank":109,"name":"Pgam1","annotation":"Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity."},{"id":"ENSMUSP00000079180","abundance":2224,"rank":110,"name":"Rps25","annotation":"40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family."},{"id":"ENSMUSP00000107595","abundance":2221,"rank":111,"name":"Hnrnpa3","annotation":"Heterogeneous nuclear ribonucleoprotein A3; Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing (By similarity)."},{"id":"ENSMUSP00000038964","abundance":2206,"rank":112,"name":"Rbm3","annotation":"RNA-binding protein 3; Cold-inducible mRNA binding protein that enhances global protein synthesis at both physiological and mild hypothermic temperatures. Reduces the relative abundance of microRNAs, when overexpressed. Enhances phosphorylation of translation initiation factors and active polysome formation."},{"id":"ENSMUSP00000112104","abundance":2166,"rank":113,"name":"Hnrnpk","annotation":"Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription  [...] "},{"id":"ENSMUSP00000100795","abundance":2163,"rank":114,"name":"Rpl10l","annotation":"60S ribosomal protein L10-like; Belongs to the universal ribosomal protein uL16 family."},{"id":"ENSMUSP00000099878","abundance":2149,"rank":115,"name":"Rps6","annotation":"40S ribosomal protein S6; May play an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA."},{"id":"ENSMUSP00000017548","abundance":2127,"rank":116,"name":"Rpl19","annotation":"60S ribosomal protein L19."},{"id":"ENSMUSP00000082055","abundance":2109,"rank":117,"name":"Rpl10","annotation":"60S ribosomal protein L10; Component of the large ribosomal subunit. Plays a role in the formation of actively translating ribosomes. May play a role in the embryonic brain development."},{"id":"ENSMUSP00000125806","abundance":2109,"rank":118,"name":"Rpl10-ps3","annotation":"Ribosomal protein L10, pseudogene 3."},{"id":"ENSMUSP00000076777","abundance":2098,"rank":119,"name":"Tuba1b","annotation":"Detyrosinated tubulin alpha-1B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family."},{"id":"ENSMUSP00000094778","abundance":2020,"rank":120,"name":"Tuba1a","annotation":"Detyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain."},{"id":"ENSMUSP00000115044","abundance":2008,"rank":121,"name":"Sumo2","annotation":"Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] "},{"id":"ENSMUSP00000134416","abundance":2000,"rank":122,"name":"Sumo3","annotation":"Small ubiquitin-related modifier 3; Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such  [...] "},{"id":"ENSMUSP00000083722","abundance":1985,"rank":123,"name":"Rpl31","annotation":"60S ribosomal protein L31; Belongs to the eukaryotic ribosomal protein eL31 family."},{"id":"ENSMUSP00000079672","abundance":1938,"rank":124,"name":"Rpl35","annotation":"60S ribosomal protein L35; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL29 family."},{"id":"ENSMUSP00000099843","abundance":1938,"rank":125,"name":"Gm2000","annotation":"Predicted gene 2000."},{"id":"ENSMUSP00000152944","abundance":1918,"rank":126,"name":"Rps24","annotation":"40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits."},{"id":"ENSMUSP00000155021","abundance":1896,"rank":127,"name":"Gm49450","annotation":"Predicted gene, 49450."},{"id":"ENSMUSP00000072227","abundance":1896,"rank":128,"name":"H2ac1","annotation":"Histone H2A; Belongs to the histone H2A family."},{"id":"ENSMUSP00000157556","abundance":1885,"rank":129,"name":"Rpl17","annotation":"60S ribosomal protein L17; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL22 family."},{"id":"ENSMUSP00000069004","abundance":1876,"rank":130,"name":"Rps15","annotation":"40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family."},{"id":"ENSMUSP00000102870","abundance":1858,"rank":131,"name":"Rpl27","annotation":"60S ribosomal protein L27; Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity)."},{"id":"ENSMUSP00000051033","abundance":1839,"rank":132,"name":"Tuba1c","annotation":"Detyrosinated tubulin alpha-1C chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family."},{"id":"ENSMUSP00000106861","abundance":1801,"rank":133,"name":"Tagln2","annotation":"Transgelin-2; Belongs to the calponin family."},{"id":"ENSMUSP00000123410","abundance":1781,"rank":134,"name":"Rpl27a","annotation":"60S ribosomal protein L27a."},{"id":"ENSMUSP00000147514","abundance":1779,"rank":135,"name":"Cfl1","annotation":"Cofilin-1; Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration ; Belongs to the actin-binding proteins ADF family."},{"id":"ENSMUSP00000140657","abundance":1733,"rank":136,"name":"Tuba4a","annotation":"Tubulin alpha-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family."},{"id":"ENSMUSP00000099904","abundance":1709,"rank":137,"name":"Ass1","annotation":"Argininosuccinate synthase; One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues."},{"id":"ENSMUSP00000085580","abundance":1703,"rank":138,"name":"Tuba3a","annotation":"Tubulin, alpha 3A."},{"id":"ENSMUSP00000084713","abundance":1703,"rank":139,"name":"Tuba3b","annotation":"Detyrosinated tubulin alpha-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family."},{"id":"ENSMUSP00000079628","abundance":1672,"rank":140,"name":"Rps17","annotation":"40S ribosomal protein S17; Belongs to the eukaryotic ribosomal protein eS17 family."},{"id":"ENSMUSP00000152609","abundance":1666,"rank":141,"name":"Ftl1-ps1","annotation":"Ferritin light polypeptide 1, pseudogene 1."},{"id":"ENSMUSP00000092002","abundance":1666,"rank":142,"name":"Ftl1","annotation":"Ferritin light chain 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney; Belongs to the ferritin family."},{"id":"ENSMUSP00000080354","abundance":1621,"rank":143,"name":"Rpl3","annotation":"60S ribosomal protein L3; The L3 protein is a component of the large subunit of cytoplasmic ribosomes."},{"id":"ENSMUSP00000032233","abundance":1574,"rank":144,"name":"Tuba8","annotation":"Tubulin alpha-8 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family."},{"id":"ENSMUSP00000138923","abundance":1567,"rank":145,"name":"Gm11214","annotation":"Predicted gene 11214."},{"id":"ENSMUSP00000079340","abundance":1550,"rank":146,"name":"Rpl36","annotation":"60S ribosomal protein L36; Component of the large ribosomal subunit."},{"id":"ENSMUSP00000103483","abundance":1547,"rank":147,"name":"Clta","annotation":"Clathrin light chain A; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge (By similarity)."},{"id":"ENSMUSP00000128803","abundance":1544,"rank":148,"name":"Myl6","annotation":"Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium."},{"id":"ENSMUSP00000030518","abundance":1525,"rank":149,"name":"Capzb","annotation":"F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By sim [...] "},{"id":"ENSMUSP00000021217","abundance":1517,"rank":150,"name":"Nme2","annotation":"Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] "},{"id":"ENSMUSP00000038352","abundance":1481,"rank":151,"name":"Rps29","annotation":"40S ribosomal protein S29."},{"id":"ENSMUSP00000019649","abundance":1476,"rank":152,"name":"Ubb","annotation":"Polyubiquitin-B; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] "},{"id":"ENSMUSP00000087736","abundance":1468,"rank":153,"name":"Actc1","annotation":"Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family."},{"id":"ENSMUSP00000119975","abundance":1464,"rank":154,"name":"Rps15a","annotation":"40S ribosomal protein S15a; Structural component of the ribosome. Required for proper erythropoiesis; Belongs to the universal ribosomal protein uS8 family."},{"id":"ENSMUSP00000148107","abundance":1449,"rank":155,"name":"Ldha","annotation":"L-lactate dehydrogenase A chain; Belongs to the LDH/MDH superfamily. LDH family."},{"id":"ENSMUSP00000106953","abundance":1416,"rank":156,"name":"Apoa2","annotation":"Proapolipoprotein A-II; May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism; Belongs to the apolipoprotein A2 family."},{"id":"ENSMUSP00000073355","abundance":1413,"rank":157,"name":"Tmsb15a","annotation":"Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family."},{"id":"ENSMUSP00000081474","abundance":1394,"rank":158,"name":"Rplp2","annotation":"60S acidic ribosomal protein P2; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family."},{"id":"ENSMUSP00000034453","abundance":1359,"rank":159,"name":"Acta1","annotation":"Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells."},{"id":"ENSMUSP00000048218","abundance":1357,"rank":160,"name":"Acta2","annotation":"Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells."},{"id":"ENSMUSP00000074658","abundance":1333,"rank":161,"name":"Actg2","annotation":"Actin, gamma-enteric smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family."},{"id":"ENSMUSP00000075513","abundance":1307,"rank":162,"name":"Eno1b","annotation":"Alpha-enolase; Glycolytic enzyme the catalyzes the conversion of 2- phosphoglycerate to phosphoenolpyruvate. In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production; Belongs to the enolase family."},{"id":"ENSMUSP00000079727","abundance":1307,"rank":163,"name":"Eno1","annotation":"Enolase 1, alpha non-neuron."},{"id":"ENSMUSP00000090897","abundance":1297,"rank":164,"name":"Hba-a1","annotation":"Hemoglobin alpha, adult chain 1."},{"id":"ENSMUSP00000090895","abundance":1297,"rank":165,"name":"Hba-a2","annotation":"Hemoglobin subunit alpha; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family."},{"id":"ENSMUSP00000046185","abundance":1281,"rank":166,"name":"Mbp","annotation":"Myelin basic protein; The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give [...] "},{"id":"ENSMUSP00000158993","abundance":1272,"rank":167,"name":"ENSMUSP00000158993","annotation":"Uncharacterized protein; Belongs to the eukaryotic ribosomal protein P1/P2 family."},{"id":"ENSMUSP00000042658","abundance":1268,"rank":168,"name":"Hnrnpa1","annotation":"Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1."},{"id":"ENSMUSP00000042457","abundance":1198,"rank":169,"name":"Eef1a1","annotation":"Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production."},{"id":"ENSMUSP00000139941","abundance":1193,"rank":170,"name":"Serpina1b","annotation":"Alpha-1-antitrypsin 1-2; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Belongs to the serpin family."},{"id":"ENSMUSP00000117045","abundance":1179,"rank":171,"name":"Srsf3","annotation":"Serine/arginine-rich splicing factor 3; Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA- binding activity. [...] "},{"id":"ENSMUSP00000129072","abundance":1151,"rank":172,"name":"Rpl26","annotation":"60S ribosomal protein L26; Component of the large ribosomal subunit."},{"id":"ENSMUSP00000134615","abundance":1146,"rank":173,"name":"Rps28","annotation":"40S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family."},{"id":"ENSMUSP00000157948","abundance":1123,"rank":174,"name":"Rps14","annotation":"40S ribosomal protein S14; Belongs to the universal ribosomal protein uS11 family."},{"id":"ENSMUSP00000027123","abundance":1121,"rank":175,"name":"Hspd1","annotation":"60 kDa heat shock protein, mitochondrial; Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per rin [...] "},{"id":"ENSMUSP00000116271","abundance":1113,"rank":176,"name":"Lcp1","annotation":"Plastin-2; Actin-binding protein. Plays a role in the activation of T- cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69."},{"id":"ENSMUSP00000127330","abundance":1077,"rank":177,"name":"Rab1a","annotation":"Ras-related protein Rab-1A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secreti [...] "},{"id":"ENSMUSP00000097919","abundance":1058,"rank":178,"name":"Mapt","annotation":"Microtubule-associated protein."},{"id":"ENSMUSP00000031617","abundance":1051,"rank":179,"name":"Rpl6","annotation":"60S ribosomal protein L6; Component of the large ribosomal subunit."},{"id":"ENSMUSP00000103940","abundance":1040,"rank":180,"name":"Rps16","annotation":"40S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family."},{"id":"ENSMUSP00000118787","abundance":1029,"rank":181,"name":"Rpl22","annotation":"60S ribosomal protein L22."},{"id":"ENSMUSP00000099435","abundance":999,"rank":182,"name":"Rpl23","annotation":"60S ribosomal protein L23."},{"id":"ENSMUSP00000106318","abundance":996,"rank":183,"name":"Oxct1","annotation":"Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)."},{"id":"ENSMUSP00000086614","abundance":995,"rank":184,"name":"Rpl34","annotation":"60S ribosomal protein L34; Component of the large ribosomal subunit."},{"id":"ENSMUSP00000023707","abundance":994,"rank":185,"name":"Sod1","annotation":"Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family."},{"id":"ENSMUSP00000136278","abundance":993,"rank":186,"name":"Tnnt3","annotation":"Troponin T, fast skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity."},{"id":"ENSMUSP00000132735","abundance":984,"rank":187,"name":"Hnrnpd","annotation":"Heterogeneous nuclear ribonucleoprotein D0; Binds with high affinity to RNA molecules that contain AU- rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-st [...] "},{"id":"ENSMUSP00000054490","abundance":969,"rank":188,"name":"Rps23","annotation":"40S ribosomal protein S23; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] "},{"id":"ENSMUSP00000099657","abundance":954,"rank":189,"name":"Hdac1","annotation":"Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium st [...] "},{"id":"ENSMUSP00000056604","abundance":953,"rank":190,"name":"H2bc1","annotation":"Histone H2B type 1-A; Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes. Inclusion of the H2AB1-H2BC1/TH2B [...] "},{"id":"ENSMUSP00000008036","abundance":933,"rank":191,"name":"Rplp1","annotation":"60S acidic ribosomal protein P1; Plays an important role in the elongation step of protein synthesis; Belongs to the eukaryotic ribosomal protein P1/P2 family."},{"id":"ENSMUSP00000099930","abundance":931,"rank":192,"name":"Set","annotation":"Protein SET; Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF- mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysi [...] "},{"id":"ENSMUSP00000073695","abundance":926,"rank":193,"name":"Serpina1c","annotation":"Alpha-1-antitrypsin 1-3; Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase. Belongs to the serpin family."},{"id":"ENSMUSP00000117022","abundance":922,"rank":194,"name":"Nme1","annotation":"Nucleoside diphosphate kinase A; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for n [...] "},{"id":"ENSMUSP00000072652","abundance":921,"rank":195,"name":"Serpina1a","annotation":"Alpha-1-antitrypsin 1-1; Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Belongs to the serpin family."},{"id":"ENSMUSP00000132590","abundance":916,"rank":196,"name":"Gm20390","annotation":"Nucleoside diphosphate kinase."},{"id":"ENSMUSP00000109938","abundance":902,"rank":197,"name":"Flna","annotation":"Filamin-A; Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adhere [...] "},{"id":"ENSMUSP00000080854","abundance":891,"rank":198,"name":"Rpl5","annotation":"60S ribosomal protein L5; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through  [...] "},{"id":"ENSMUSP00000001566","abundance":884,"rank":199,"name":"Tubb5","annotation":"Tubulin beta-5 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family."},{"id":"ENSMUSP00000026420","abundance":883,"rank":200,"name":"Rps26","annotation":"40S ribosomal protein S26; Belongs to the eukaryotic ribosomal protein eS26 family."},{"id":"ENSMUSP00000031862","abundance":875,"rank":201,"name":"Cbx3","annotation":"Chromobox protein homolog 3; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Probably involved in the repression of many genes located in euchromatin, such as E2F1, MYC and CDC25A. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin- like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box [...] "},{"id":"ENSMUSP00000127034","abundance":872,"rank":202,"name":"Eif4a1","annotation":"Eukaryotic initiation factor 4A-I; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily."},{"id":"ENSMUSP00000104731","abundance":867,"rank":203,"name":"Hnrnpab","annotation":"Heterogeneous nuclear ribonucleoprotein A/B; Transcriptional repressor. Binds to CArG box motifs, single- stranded and double-stranded DNA, and RNA. It may be that repression by CBF-A is a result of competitive binding of CBF, a putative positive factor, and CBF-A to the same or overlapping motifs around the CArG boxes."},{"id":"ENSMUSP00000099938","abundance":865,"rank":204,"name":"Mdh1","annotation":"Malate dehydrogenase, cytoplasmic."},{"id":"ENSMUSP00000084846","abundance":863,"rank":205,"name":"Aldoa","annotation":"Fructose-bisphosphate aldolase A; Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). Belongs to the class I fructose-bisphosphate aldolase family."},{"id":"ENSMUSP00000036907","abundance":856,"rank":206,"name":"H2az1","annotation":"Histone H2A.Z; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] "},{"id":"ENSMUSP00000105359","abundance":856,"rank":207,"name":"H2az2","annotation":"Histone H2A.V; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for c [...] "},{"id":"ENSMUSP00000090059","abundance":856,"rank":208,"name":"Srsf2","annotation":"Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA (By similarity). Can bind to the myelin basic protein (MBP) gene MB3 regulatory region and increase transcription of the mbp promoter in cells derived from the CNS. The phosphorylated form (by SRPK2) is required for cellular apoptos [...] "},{"id":"ENSMUSP00000099595","abundance":853,"rank":209,"name":"Rpl11","annotation":"60S ribosomal protein L11; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through [...] "},{"id":"ENSMUSP00000060246","abundance":851,"rank":210,"name":"Tubb2a","annotation":"Tubulin beta-2A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family."},{"id":"ENSMUSP00000052086","abundance":849,"rank":211,"name":"Actbl2","annotation":"Beta-actin-like protein 2; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family."},{"id":"ENSMUSP00000042342","abundance":845,"rank":212,"name":"Tubb4b","annotation":"Tubulin beta-4B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family."},{"id":"ENSMUSP00000075178","abundance":845,"rank":213,"name":"Tubb2b","annotation":"Tubulin beta-2B chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Plays a critical role in proper axon guidance in both central and peripheral axon tracts. Implicated in neuronal migration."},{"id":"ENSMUSP00000091943","abundance":838,"rank":214,"name":"Tpd52","annotation":"Tumor protein D52; Belongs to the TPD52 family."},{"id":"ENSMUSP00000147816","abundance":837,"rank":215,"name":"Rpl18","annotation":"60S ribosomal protein L18; Component of the large ribosomal subunit."},{"id":"ENSMUSP00000072829","abundance":830,"rank":216,"name":"Gm10053","annotation":"Cytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain."},{"id":"ENSMUSP00000124523","abundance":830,"rank":217,"name":"Cycs","annotation":"Cytochrome c, somatic."},{"id":"ENSMUSP00000158296","abundance":798,"rank":218,"name":"Glo1","annotation":"Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis."},{"id":"ENSMUSP00000034834","abundance":798,"rank":219,"name":"Pkm","annotation":"Pyruvate kinase PKM; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP (By similarity). Stimulates POU5F1-mediated transcriptional activation (By similarity). Promotes in a STAT1-dependent manner, the expression of the immune checkpoint protein CD274 in ARNTL/BMAL1-deficient macrophages."},{"id":"ENSMUSP00000113606","abundance":793,"rank":220,"name":"Serpina1e","annotation":"Alpha-1-antitrypsin 1-5; Does not inhibit elastase or chymotrypsin. No target protease has been identified to date; Belongs to the serpin family."},{"id":"ENSMUSP00000026495","abundance":786,"rank":221,"name":"Atp5a1","annotation":"ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the  [...] "},{"id":"ENSMUSP00000099613","abundance":757,"rank":222,"name":"Hmgn2","annotation":"High mobility group nucleosomal binding domain 2."},{"id":"ENSMUSP00000075031","abundance":757,"rank":223,"name":"Gm10282","annotation":"Non-histone chromosomal protein HMG-17; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity)."},{"id":"ENSMUSP00000077909","abundance":748,"rank":224,"name":"Serpina1d","annotation":"Alpha-1-antitrypsin 1-4; Inhibitor of serine proteases. Can inhibit trypsin and chymotrypsin; relatively ineffective against elastase. Belongs to the serpin family."},{"id":"ENSMUSP00000016396","abundance":733,"rank":225,"name":"Atp5e","annotation":"ATP synthase subunit epsilon, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of th [...] "},{"id":"ENSMUSP00000008812","abundance":719,"rank":226,"name":"Rps18","annotation":"40S ribosomal protein S18; Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA."},{"id":"ENSMUSP00000100937","abundance":712,"rank":227,"name":"Igf1","annotation":"Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (By similarity). Ca(2 [...] "},{"id":"ENSMUSP00000138961","abundance":712,"rank":228,"name":"Gm14214","annotation":"Predicted gene 14214."},{"id":"ENSMUSP00000071135","abundance":705,"rank":229,"name":"Tubb4a","annotation":"Tubulin beta-4A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain."},{"id":"ENSMUSP00000029722","abundance":704,"rank":230,"name":"Rps3a1","annotation":"40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3."},{"id":"ENSMUSP00000102147","abundance":699,"rank":231,"name":"Atp5h","annotation":"ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] "},{"id":"ENSMUSP00000114159","abundance":696,"rank":232,"name":"Prdx1","annotation":"Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...] "},{"id":"ENSMUSP00000004378","abundance":689,"rank":233,"name":"Eno2","annotation":"Gamma-enolase; Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium- dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity); Belongs to the enolase family."},{"id":"ENSMUSP00000032228","abundance":672,"rank":234,"name":"Mug1","annotation":"Murinoglobulin-1; A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, f [...] "},{"id":"ENSMUSP00000152211","abundance":665,"rank":235,"name":"Rps18-ps5","annotation":"Ribosomal protein S18, pseudogene 5; Belongs to the universal ribosomal protein uS13 family."},{"id":"ENSMUSP00000032597","abundance":662,"rank":236,"name":"Rpl28","annotation":"60S ribosomal protein L28; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL28 family."},{"id":"ENSMUSP00000028222","abundance":660,"rank":237,"name":"Hspa5","annotation":"Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate. Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimeriz [...] "},{"id":"ENSMUSP00000091840","abundance":659,"rank":238,"name":"Snu13","annotation":"NHP2-like protein 1, N-terminally processed; Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding."},{"id":"ENSMUSP00000099381","abundance":657,"rank":239,"name":"Ctsa","annotation":"Lysosomal protective protein 20 kDa chain; Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins."},{"id":"ENSMUSP00000088618","abundance":650,"rank":240,"name":"Dnm1","annotation":"Dynamin-1; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis (By similarity)."},{"id":"ENSMUSP00000089801","abundance":646,"rank":241,"name":"Lyz2","annotation":"Lysozyme C-2; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz2 is active against a range of Gram-positive and Gram-negative bacteria. More effective than Lyz1 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria; Belongs to the glycosyl hydrolase 22 family."},{"id":"ENSMUSP00000121116","abundance":643,"rank":242,"name":"Sptan1","annotation":"Spectrin alpha chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane."},{"id":"ENSMUSP00000070983","abundance":641,"rank":243,"name":"Srsf7","annotation":"Serine/arginine-rich splicing factor 7; Required for pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi- sequence specific (By similarity); Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000099384","abundance":639,"rank":244,"name":"Tnnc2","annotation":"Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments."},{"id":"ENSMUSP00000099819","abundance":637,"rank":245,"name":"Vdac1","annotation":"Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] "},{"id":"ENSMUSP00000126892","abundance":636,"rank":246,"name":"Gm10260","annotation":"Ribosomal protein S18, pseudogene 6; Belongs to the universal ribosomal protein uS13 family."},{"id":"ENSMUSP00000048469","abundance":635,"rank":247,"name":"Rpl10a","annotation":"60S ribosomal protein L10a; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL1 family."},{"id":"ENSMUSP00000050289","abundance":619,"rank":248,"name":"Eif5a2","annotation":"Eukaryotic translation initiation factor 5A-2; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By s [...] "},{"id":"ENSMUSP00000114180","abundance":609,"rank":249,"name":"Ubc","annotation":"Ubiquitin-related 1; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA re [...] "},{"id":"ENSMUSP00000063734","abundance":603,"rank":250,"name":"Ezr","annotation":"Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity)."},{"id":"ENSMUSP00000151408","abundance":600,"rank":251,"name":"Hspa2","annotation":"Heat shock-related 70 kDa protein 2; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis [...] "},{"id":"ENSMUSP00000126294","abundance":597,"rank":252,"name":"Rps13","annotation":"40S ribosomal protein S13; Belongs to the universal ribosomal protein uS15 family."},{"id":"ENSMUSP00000101006","abundance":592,"rank":253,"name":"Atp5d","annotation":"ATP synthase subunit delta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] "},{"id":"ENSMUSP00000091921","abundance":589,"rank":254,"name":"Hsp90aa1","annotation":"Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] "},{"id":"ENSMUSP00000101299","abundance":588,"rank":255,"name":"Park7","annotation":"Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] "},{"id":"ENSMUSP00000109399","abundance":585,"rank":256,"name":"Rpl9","annotation":"60S ribosomal protein L9; Belongs to the universal ribosomal protein uL6 family."},{"id":"ENSMUSP00000039657","abundance":579,"rank":257,"name":"Atp1a1","annotation":"Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily."},{"id":"ENSMUSP00000113071","abundance":578,"rank":258,"name":"Msn","annotation":"Moesin; Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton (By similarity). Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement (By similarity). These rearrangements regulate many cellular processes, including cel [...] "},{"id":"ENSMUSP00000104265","abundance":563,"rank":259,"name":"Rps9","annotation":"40S ribosomal protein S9; Belongs to the universal ribosomal protein uS4 family."},{"id":"ENSMUSP00000078867","abundance":562,"rank":260,"name":"Ewsr1","annotation":"RNA-binding protein EWS; Might function as a transcriptional repressor."},{"id":"ENSMUSP00000127859","abundance":560,"rank":261,"name":"Rpl9-ps6","annotation":"Ribosomal protein L9, pseudogene 6."},{"id":"ENSMUSP00000003521","abundance":558,"rank":262,"name":"Rps11","annotation":"40S ribosomal protein S11."},{"id":"ENSMUSP00000041250","abundance":557,"rank":263,"name":"Serpina3g","annotation":"Serine protease inhibitor A3G; Belongs to the serpin family."},{"id":"ENSMUSP00000073880","abundance":548,"rank":264,"name":"Rps7","annotation":"40S ribosomal protein S7; Required for rRNA maturation."},{"id":"ENSMUSP00000016463","abundance":542,"rank":265,"name":"Slc25a5","annotation":"ADP/ATP translocase 2, N-terminally processed; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity)."},{"id":"ENSMUSP00000092242","abundance":534,"rank":266,"name":"Dnajc8","annotation":"DnaJ homolog subfamily C member 8; Suppresses polyglutamine (polyQ) aggregation of ATXN3 in neuronal cells."},{"id":"ENSMUSP00000028062","abundance":534,"rank":267,"name":"Vim","annotation":"Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally."},{"id":"ENSMUSP00000109705","abundance":534,"rank":268,"name":"Capg","annotation":"Macrophage-capping protein; Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+); Belongs to the villin/gelsolin family."},{"id":"ENSMUSP00000027151","abundance":533,"rank":269,"name":"Myl1","annotation":"Myosin light chain 1/3, skeletal muscle isoform; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function."},{"id":"ENSMUSP00000035105","abundance":530,"rank":270,"name":"Rpsa","annotation":"40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteri [...] "},{"id":"ENSMUSP00000101858","abundance":524,"rank":271,"name":"Fus","annotation":"RNA-binding protein FUS; DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination  [...] "},{"id":"ENSMUSP00000033683","abundance":524,"rank":272,"name":"Rps4x","annotation":"40S ribosomal protein S4, X isoform; Belongs to the eukaryotic ribosomal protein eS4 family."},{"id":"ENSMUSP00000044188","abundance":523,"rank":273,"name":"Ptma","annotation":"Prothymosin alpha, N-terminally processed; Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections; Belongs to the pro/parathymosin family."},{"id":"ENSMUSP00000108837","abundance":522,"rank":274,"name":"Rpl36a","annotation":"Ribosomal protein L36A."},{"id":"ENSMUSP00000106249","abundance":522,"rank":275,"name":"Rpl36al","annotation":"60S ribosomal protein L36a."},{"id":"ENSMUSP00000106519","abundance":521,"rank":276,"name":"Tpt1","annotation":"Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization."},{"id":"ENSMUSP00000110417","abundance":521,"rank":277,"name":"Fhl1","annotation":"Four and a half LIM domains protein 1; May have an involvement in muscle development or hypertrophy. Isoform 2 binds to RBP-J and plays a negative regulatory role in the RBP-J-mediated transcription in mammalian systems."},{"id":"ENSMUSP00000032373","abundance":520,"rank":278,"name":"Ldhb","annotation":"L-lactate dehydrogenase B chain; Belongs to the LDH/MDH superfamily. LDH family."},{"id":"ENSMUSP00000079691","abundance":518,"rank":279,"name":"Atp1a3","annotation":"Sodium/potassium-transporting ATPase subunit alpha-3; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily."},{"id":"ENSMUSP00000039433","abundance":518,"rank":280,"name":"Etfrf1","annotation":"Electron transfer flavoprotein regulatory factor 1; Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB)."},{"id":"ENSMUSP00000095654","abundance":516,"rank":281,"name":"Mup11","annotation":"Major urinary protein 11."},{"id":"ENSMUSP00000095648","abundance":516,"rank":282,"name":"Mup18","annotation":"Major urinary protein 11; Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (Probable). Binds the pheromone analog 2- sec-butyl-4,5-dihydrothiazole (SBT) in vitro. Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000071616","abundance":515,"rank":283,"name":"Rpl7","annotation":"60S ribosomal protein L7; Component of the large ribosomal subunit (By similarity). Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity); Belongs to the universal ribosomal protein uL30 family."},{"id":"ENSMUSP00000104179","abundance":512,"rank":284,"name":"Rps5","annotation":"40S ribosomal protein S5, N-terminally processed; Belongs to the universal ribosomal protein uS7 family."},{"id":"ENSMUSP00000148722","abundance":511,"rank":285,"name":"Mup22","annotation":"Major urinary protein 22; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000112923","abundance":506,"rank":286,"name":"Mgst1","annotation":"Microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles."},{"id":"ENSMUSP00000112787","abundance":506,"rank":287,"name":"Mup12","annotation":"Major urinary protein 1; Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females."},{"id":"ENSMUSP00000120528","abundance":503,"rank":288,"name":"Rps20","annotation":"40S ribosomal protein S20."},{"id":"ENSMUSP00000092659","abundance":501,"rank":289,"name":"Mup15","annotation":"Major urinary protein 15; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000156121","abundance":500,"rank":290,"name":"Ube2l3","annotation":"Ubiquitin-conjugating enzyme E2 L3; Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the [...] "},{"id":"ENSMUSP00000074696","abundance":500,"rank":291,"name":"Mup14","annotation":"Major urinary protein 12; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000078636","abundance":500,"rank":292,"name":"Mup7","annotation":"Novel member of the major urinary protein (Mup) gene family; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000103964","abundance":496,"rank":293,"name":"Cp","annotation":"Ceruloplasmin; Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity)."},{"id":"ENSMUSP00000092668","abundance":494,"rank":294,"name":"Mup8","annotation":"Major urinary protein 5; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000133728","abundance":490,"rank":295,"name":"Hnrnpl","annotation":"Heterogeneous nuclear ribonucleoprotein L; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter."},{"id":"ENSMUSP00000113741","abundance":487,"rank":296,"name":"Mup9","annotation":"Major urinary protein 9."},{"id":"ENSMUSP00000103107","abundance":487,"rank":297,"name":"Mup16","annotation":"Major urinary protein 16."},{"id":"ENSMUSP00000079442","abundance":487,"rank":298,"name":"Mup19","annotation":"Major urinary protein 6; Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females."},{"id":"ENSMUSP00000061800","abundance":485,"rank":299,"name":"Chtop","annotation":"Chromatin target of PRMT1 protein; Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Required for the tumorigenicity of glioblastoma cells. Binds to 5- hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivate [...] "},{"id":"ENSMUSP00000001809","abundance":485,"rank":300,"name":"Pabpc1","annotation":"Polyadenylate-binding protein 1; Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region deter [...] "},{"id":"ENSMUSP00000074264","abundance":482,"rank":301,"name":"Mup2","annotation":"Major urinary protein 2; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000095655","abundance":480,"rank":302,"name":"Mup10","annotation":"Major urinary protein 2; Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females."},{"id":"ENSMUSP00000071134","abundance":479,"rank":303,"name":"Tubb3","annotation":"Tubulin beta-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord (By similarity)."},{"id":"ENSMUSP00000024739","abundance":475,"rank":304,"name":"Hsp90ab1","annotation":"Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] "},{"id":"ENSMUSP00000005077","abundance":475,"rank":305,"name":"Hspb1","annotation":"Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity)."},{"id":"ENSMUSP00000103108","abundance":471,"rank":306,"name":"Mup17","annotation":"Major urinary protein 17; Major urinary proteins (Mups) bind pheromones, thus stabilize them and allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance (By similarity)."},{"id":"ENSMUSP00000083077","abundance":469,"rank":307,"name":"Atp1a2","annotation":"Sodium/potassium-transporting ATPase subunit alpha-2; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity)."},{"id":"ENSMUSP00000101479","abundance":466,"rank":308,"name":"Srsf10","annotation":"Serine/arginine-rich splicing factor 10; Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing. Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70. Required for splicing repression in M-phase cells and after heat shock. Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A- containing regions, lea [...] "},{"id":"ENSMUSP00000031726","abundance":464,"rank":309,"name":"Gnb2","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000104511","abundance":463,"rank":310,"name":"Anxa6","annotation":"Annexin A6; May associate with CD21. May regulate the release of Ca(2+) from intracellular stores; Belongs to the annexin family."},{"id":"ENSMUSP00000034588","abundance":456,"rank":311,"name":"Apoa1","annotation":"Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family."},{"id":"ENSMUSP00000099952","abundance":452,"rank":312,"name":"Camk2a","annotation":"Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development. Also regulates the migration of developing neurons (By similarity). Phosphorylates  [...] "},{"id":"ENSMUSP00000021090","abundance":451,"rank":313,"name":"Grb2","annotation":"Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway; Belongs to the GRB2/sem-5/DRK family."},{"id":"ENSMUSP00000081142","abundance":450,"rank":314,"name":"Tardbp","annotation":"TAR DNA-binding protein 43; RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondria [...] "},{"id":"ENSMUSP00000091041","abundance":449,"rank":315,"name":"Ogdh","annotation":"2-oxoglutarate dehydrogenase, mitochondrial; 2-oxoglutarate dehydrogenase (E1) component of the 2- oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl- Co [...] "},{"id":"ENSMUSP00000108828","abundance":443,"rank":316,"name":"Hnrnph2","annotation":"Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity)."},{"id":"ENSMUSP00000147411","abundance":442,"rank":317,"name":"Gm10131","annotation":"Predicted pseudogene 10131."},{"id":"ENSMUSP00000072466","abundance":437,"rank":318,"name":"Mup13","annotation":"Major urinary protein 11; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000141166","abundance":434,"rank":319,"name":"Gm28635","annotation":"Predicted gene 28635."},{"id":"ENSMUSP00000064518","abundance":434,"rank":320,"name":"Ctnnd1","annotation":"Catenin delta-1; Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors."},{"id":"ENSMUSP00000079022","abundance":433,"rank":321,"name":"Aldoart2","annotation":"Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family."},{"id":"ENSMUSP00000030636","abundance":433,"rank":322,"name":"Stmn1","annotation":"Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis (By similarity). Involved in the control of the learned and innate fear."},{"id":"ENSMUSP00000030583","abundance":432,"rank":323,"name":"Ak2","annotation":"Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis."},{"id":"ENSMUSP00000006629","abundance":430,"rank":324,"name":"Sptbn1","annotation":"Spectrin beta chain, non-erythrocytic 1; Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane."},{"id":"ENSMUSP00000130123","abundance":428,"rank":325,"name":"Gnb1","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)."},{"id":"ENSMUSP00000156199","abundance":425,"rank":326,"name":"Hmga1","annotation":"High mobility group AT-hook 1."},{"id":"ENSMUSP00000100667","abundance":425,"rank":327,"name":"Hmga1b","annotation":"High mobility group protein HMG-I/HMG-Y; HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions; Belongs to the HMGA family."},{"id":"ENSMUSP00000153782","abundance":423,"rank":328,"name":"Rpl36a-ps1","annotation":"Ribosomal protein L36A, pseudogene 1; Belongs to the eukaryotic ribosomal protein eL42 family."},{"id":"ENSMUSP00000134169","abundance":419,"rank":329,"name":"Ube2i","annotation":"SUMO-conjugating enzyme UBC9; Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386'. Mediates sumoylation of ERCC6 which is essential for its transcription-coupled nucleotide excision repair activity (By si [...] "},{"id":"ENSMUSP00000143677","abundance":418,"rank":330,"name":"Camk2d","annotation":"Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopath [...] "},{"id":"ENSMUSP00000130023","abundance":417,"rank":331,"name":"Hnrnpf","annotation":"Heterogeneous nuclear ribonucleoprotein F, N-terminally processed; Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state (By similarity)."},{"id":"ENSMUSP00000079070","abundance":414,"rank":332,"name":"Pabpc4","annotation":"Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family."},{"id":"ENSMUSP00000076989","abundance":413,"rank":333,"name":"Hnrnph1","annotation":"Heterogeneous nuclear ribonucleoprotein H, N-terminally processed; This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity)."},{"id":"ENSMUSP00000016771","abundance":410,"rank":334,"name":"Myh9","annotation":"Myosin-9; During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000034756","abundance":409,"rank":335,"name":"Anxa2","annotation":"Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family."},{"id":"ENSMUSP00000020640","abundance":409,"rank":336,"name":"Rack1","annotation":"Receptor of activated protein C kinase 1, N-terminally processed; Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (By similarity). Binds to and stabilizes a [...] "},{"id":"ENSMUSP00000099368","abundance":408,"rank":337,"name":"Cttn","annotation":"Src substrate cortactin; Contributes to the organization of the actin cytoskeleton and cell shape. Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density. Plays a role in the invasiveness of cancer cells, and the formation of metastases (By similarity). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and M [...] "},{"id":"ENSMUSP00000074436","abundance":408,"rank":338,"name":"Hp","annotation":"Haptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] "},{"id":"ENSMUSP00000123605","abundance":407,"rank":339,"name":"Ywhaq","annotation":"14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)."},{"id":"ENSMUSP00000023790","abundance":407,"rank":340,"name":"Krt1","annotation":"Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK (By similarity); Belongs to the intermediate filament family."},{"id":"ENSMUSP00000099587","abundance":406,"rank":341,"name":"Ppp1cc","annotation":"Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] "},{"id":"ENSMUSP00000087925","abundance":406,"rank":342,"name":"Camk2b","annotation":"Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeti [...] "},{"id":"ENSMUSP00000046101","abundance":402,"rank":343,"name":"Eef2","annotation":"Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily."},{"id":"ENSMUSP00000034097","abundance":402,"rank":344,"name":"Got2","annotation":"Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids."},{"id":"ENSMUSP00000129620","abundance":401,"rank":345,"name":"Erh","annotation":"Enhancer of rudimentary homolog; May have a role in the cell cycle; Belongs to the E(R) family."},{"id":"ENSMUSP00000073124","abundance":400,"rank":346,"name":"Plec","annotation":"Plectin; Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics; Belongs to the plakin or cytolinker family."},{"id":"ENSMUSP00000126192","abundance":398,"rank":347,"name":"Ptbp1","annotation":"Polypyrimidine tract-binding protein 1; Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre- mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre- mRNA. Represses the splicing of MAPT/Tau exon 10."},{"id":"ENSMUSP00000110434","abundance":398,"rank":348,"name":"Hadhb","annotation":"Trifunctional enzyme subunit beta, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enz [...] "},{"id":"ENSMUSP00000057308","abundance":395,"rank":349,"name":"H1f4","annotation":"Histone H1.4; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation."},{"id":"ENSMUSP00000050292","abundance":394,"rank":350,"name":"Ptges3","annotation":"Prostaglandin E synthase 3; Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway; Belongs to the p23/wos2 family."},{"id":"ENSMUSP00000081596","abundance":394,"rank":351,"name":"Mup1","annotation":"Major urinary protein 1; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000155052","abundance":392,"rank":352,"name":"Myh11","annotation":"Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000021993","abundance":389,"rank":353,"name":"Uqcrb","annotation":"Cytochrome b-c1 complex subunit 7; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] "},{"id":"ENSMUSP00000113571","abundance":389,"rank":354,"name":"Ank1","annotation":"Ankyrin-1; Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. In skeletal muscle, isoform Mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils."},{"id":"ENSMUSP00000042095","abundance":387,"rank":355,"name":"Serpina3k","annotation":"Serine protease inhibitor A3K; Contrapsin inhibits trypsin-like proteases."},{"id":"ENSMUSP00000106975","abundance":386,"rank":356,"name":"Ran","annotation":"GTP-binding nuclear protein Ran; GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP- bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment [...] "},{"id":"ENSMUSP00000076880","abundance":380,"rank":357,"name":"Calml3","annotation":"Calmodulin-like protein 3; May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity)."},{"id":"ENSMUSP00000121005","abundance":377,"rank":358,"name":"Hnrnpdl","annotation":"Heterogeneous nuclear ribonucleoprotein D-like; Acts as a transcriptional regulator. Promotes transcription repression (By similarity). Promotes transcription activation in differentiated myotubes. Binds to double- and single-stranded DNA sequences (By similarity). Binds to the transcription suppressor CATR sequence of the COX5B promoter. Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs (By similarity). Binds both to nuclear and cytoplasmic poly(A) mRNAs (By similarity). Binds to poly(G) an [...] "},{"id":"ENSMUSP00000023608","abundance":377,"rank":359,"name":"Atp5j","annotation":"ATP synthase-coupling factor 6, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of t [...] "},{"id":"ENSMUSP00000083705","abundance":376,"rank":360,"name":"Rplp0","annotation":"60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10."},{"id":"ENSMUSP00000039109","abundance":375,"rank":361,"name":"Ppp1ca","annotation":"Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] "},{"id":"ENSMUSP00000103474","abundance":374,"rank":362,"name":"Prmt1","annotation":"Protein arginine N-methyltransferase 1; Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation (By similarity). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1 [...] "},{"id":"ENSMUSP00000034966","abundance":372,"rank":363,"name":"Rpl4","annotation":"60S ribosomal protein L4; Belongs to the universal ribosomal protein uL4 family."},{"id":"ENSMUSP00000000590","abundance":372,"rank":364,"name":"Rdx","annotation":"Radixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane."},{"id":"ENSMUSP00000095794","abundance":369,"rank":365,"name":"Hbb-bt","annotation":"Hemoglobin, beta adult t chain."},{"id":"ENSMUSP00000023934","abundance":369,"rank":366,"name":"Hbb-bs","annotation":"Hemoglobin subunit beta-1; Involved in oxygen transport from the lung to the various peripheral tissues."},{"id":"ENSMUSP00000105356","abundance":361,"rank":367,"name":"Prdx2","annotation":"Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)."},{"id":"ENSMUSP00000130858","abundance":361,"rank":368,"name":"Tpi1","annotation":"Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis."},{"id":"ENSMUSP00000048425","abundance":358,"rank":369,"name":"Pebp1","annotation":"Hippocampal cholinergic neurostimulating peptide; Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity)."},{"id":"ENSMUSP00000028239","abundance":358,"rank":370,"name":"Gsn","annotation":"Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family."},{"id":"ENSMUSP00000077687","abundance":355,"rank":371,"name":"Aldoart1","annotation":"Fructose-bisphosphate aldolase; Belongs to the class I fructose-bisphosphate aldolase family."},{"id":"ENSMUSP00000015100","abundance":354,"rank":372,"name":"Ppp1cb","annotation":"Serine/threonine-protein phosphatase PP1-beta catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progressi [...] "},{"id":"ENSMUSP00000061227","abundance":354,"rank":373,"name":"Pgm1","annotation":"Phosphoglucomutase-1; This enzyme participates in both the breakdown and synthesis of glucose; Belongs to the phosphohexose mutase family."},{"id":"ENSMUSP00000017534","abundance":352,"rank":374,"name":"Aldoc","annotation":"Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family."},{"id":"ENSMUSP00000032138","abundance":352,"rank":375,"name":"Cnbp","annotation":"Cellular nucleic acid-binding protein; Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression."},{"id":"ENSMUSP00000099671","abundance":351,"rank":376,"name":"Myh10","annotation":"Myosin-10; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping."},{"id":"ENSMUSP00000018470","abundance":349,"rank":377,"name":"Ywhab","annotation":"14-3-3 protein beta/alpha, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by  [...] "},{"id":"ENSMUSP00000044395","abundance":348,"rank":378,"name":"H1f3","annotation":"Histone H1.3; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)."},{"id":"ENSMUSP00000070993","abundance":347,"rank":379,"name":"Ywhae","annotation":"14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm. Belongs to the 14-3-3 family."},{"id":"ENSMUSP00000107237","abundance":346,"rank":380,"name":"Hnrnpc","annotation":"Heterogeneous nuclear ribonucleoproteins C1/C2; Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', fa [...] "},{"id":"ENSMUSP00000082125","abundance":345,"rank":381,"name":"Serpina3c","annotation":"Serine protease inhibitor A3C."},{"id":"ENSMUSP00000105980","abundance":345,"rank":382,"name":"Srsf5","annotation":"Serine/arginine-rich splicing factor 5; May be required for progression through G1 and entry into S phase of cell growth. May play a regulatory role in pre-mRNA splicing. Autoregulates its own expression. Plays a role in constitutive splicing and can modulate the selection of alternative splice sites (By similarity); Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000109230","abundance":345,"rank":383,"name":"Rab7","annotation":"Ras-related protein Rab-7a; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulat [...] "},{"id":"ENSMUSP00000025804","abundance":344,"rank":384,"name":"Rab1b","annotation":"Ras-related protein Rab-1B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates  [...] "},{"id":"ENSMUSP00000001513","abundance":342,"rank":385,"name":"Tubb6","annotation":"Tubulin beta-6 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain."},{"id":"ENSMUSP00000083375","abundance":339,"rank":386,"name":"Glul","annotation":"Glutamine synthetase; Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (By similarity). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia. Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development. Involved in angiog [...] "},{"id":"ENSMUSP00000130979","abundance":338,"rank":387,"name":"Serpina3m","annotation":"Serine protease inhibitor A3M; Belongs to the serpin family."},{"id":"ENSMUSP00000077509","abundance":336,"rank":388,"name":"Pcbp2","annotation":"Poly(rC)-binding protein 2; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation (By similarity)."},{"id":"ENSMUSP00000045816","abundance":334,"rank":389,"name":"H1f2","annotation":"Histone H1.2; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)."},{"id":"ENSMUSP00000105602","abundance":333,"rank":390,"name":"Eef1d","annotation":"Elongation factor 1-delta; [Isoform 1]: EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP, regenerating EF-1-alpha for another round of transfer of aminoacyl-tRNAs to the ribosome."},{"id":"ENSMUSP00000020768","abundance":333,"rank":391,"name":"Pgam2","annotation":"Phosphoglycerate mutase 2; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity."},{"id":"ENSMUSP00000140174","abundance":333,"rank":392,"name":"Gnas","annotation":"Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms."},{"id":"ENSMUSP00000137476","abundance":333,"rank":393,"name":"Psap","annotation":"Saposin-B-Val; [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.  Saposins are specific low-mol [...] "},{"id":"ENSMUSP00000121309","abundance":333,"rank":394,"name":"Sf1","annotation":"Splicing factor 1; Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor (By similarity). Belongs to the BBP/SF1 family."},{"id":"ENSMUSP00000021506","abundance":333,"rank":395,"name":"Serpina3n","annotation":"Serine protease inhibitor A3N."},{"id":"ENSMUSP00000119603","abundance":330,"rank":396,"name":"Phb","annotation":"Prohibitin; Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging (By similarity)."},{"id":"ENSMUSP00000114014","abundance":329,"rank":397,"name":"Gng5","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000063714","abundance":329,"rank":398,"name":"Arhgdia","annotation":"Rho GDP-dissociation inhibitor 1; Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. T [...] "},{"id":"ENSMUSP00000078589","abundance":324,"rank":399,"name":"Ybx1","annotation":"Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (By similarity). Component of the CRD-mediated co [...] "},{"id":"ENSMUSP00000126120","abundance":322,"rank":400,"name":"Arf1","annotation":"ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form  [...] "},{"id":"ENSMUSP00000074724","abundance":321,"rank":401,"name":"Hspe1","annotation":"10 kDa heat shock protein, mitochondrial; Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per  [...] "},{"id":"ENSMUSP00000050689","abundance":321,"rank":402,"name":"Arf3","annotation":"ADP-ribosylation factor 3; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus."},{"id":"ENSMUSP00000033585","abundance":321,"rank":403,"name":"Pgk2","annotation":"Phosphoglycerate kinase 2; Essential for sperm motility and male fertility but is not required for the completion of spermatogenesis."},{"id":"ENSMUSP00000110547","abundance":319,"rank":404,"name":"Atp5c1","annotation":"ATP synthase subunit gamma, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the  [...] "},{"id":"ENSMUSP00000068971","abundance":318,"rank":405,"name":"Serpinc1","annotation":"Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity)."},{"id":"ENSMUSP00000145350","abundance":314,"rank":406,"name":"Rpl32","annotation":"60S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family."},{"id":"ENSMUSP00000016081","abundance":314,"rank":407,"name":"Macroh2a1","annotation":"Core histone macro-H2A.1; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation [...] "},{"id":"ENSMUSP00000091475","abundance":312,"rank":408,"name":"Cbx1","annotation":"Chromobox protein homolog 1; Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane."},{"id":"ENSMUSP00000158539","abundance":308,"rank":409,"name":"Fth1","annotation":"Ferritin heavy chain, N-terminally processed; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney."},{"id":"ENSMUSP00000037613","abundance":307,"rank":410,"name":"Fbl","annotation":"rRNA 2'-O-methyltransferase fibrillarin; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (By similarity). Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone [...] "},{"id":"ENSMUSP00000065940","abundance":306,"rank":411,"name":"Hmgb2","annotation":"High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non- canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bring [...] "},{"id":"ENSMUSP00000099475","abundance":306,"rank":412,"name":"Cltc","annotation":"Clathrin heavy chain 1; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans- Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch- TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation."},{"id":"ENSMUSP00000131489","abundance":306,"rank":413,"name":"Rpl14","annotation":"60S ribosomal protein L14; Component of the large ribosomal subunit. Belongs to the eukaryotic ribosomal protein eL14 family."},{"id":"ENSMUSP00000149803","abundance":305,"rank":414,"name":"Cryab","annotation":"Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions."},{"id":"ENSMUSP00000003575","abundance":305,"rank":415,"name":"Tpm4","annotation":"Tropomyosin alpha-4 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium; Belongs to the tropomyosin family."},{"id":"ENSMUSP00000071720","abundance":305,"rank":416,"name":"Camk2g","annotation":"Calcium/calmodulin-dependent protein kinase type II subunit gamma; Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-cou [...] "},{"id":"ENSMUSP00000026572","abundance":305,"rank":417,"name":"Hras","annotation":"GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity."},{"id":"ENSMUSP00000054499","abundance":303,"rank":418,"name":"Fn1","annotation":"Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts."},{"id":"ENSMUSP00000054556","abundance":301,"rank":419,"name":"Eef1a2","annotation":"Elongation factor 1-alpha 2; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily."},{"id":"ENSMUSP00000099461","abundance":299,"rank":420,"name":"Dstn","annotation":"Destrin; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner; Belongs to the actin-binding proteins ADF family."},{"id":"ENSMUSP00000147751","abundance":298,"rank":421,"name":"Saa2","annotation":"Serum amyloid A-2 protein; Major acute phase reactant. Apolipoprotein of the HDL complex."},{"id":"ENSMUSP00000066181","abundance":297,"rank":422,"name":"Immt","annotation":"MICOS complex subunit Mic60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology."},{"id":"ENSMUSP00000003554","abundance":293,"rank":423,"name":"Casq1","annotation":"Calsequestrin-1; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions (By similarity). Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction. Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity)."},{"id":"ENSMUSP00000126390","abundance":293,"rank":424,"name":"Serpinh1","annotation":"Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen."},{"id":"ENSMUSP00000157281","abundance":289,"rank":425,"name":"Hspe1-rs1","annotation":"Heat shock protein 1 (chaperonin 10),-related sequence 1; Belongs to the GroES chaperonin family."},{"id":"ENSMUSP00000084586","abundance":289,"rank":426,"name":"Hspa1a","annotation":"Heat shock 70 kDa protein 1A; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] "},{"id":"ENSMUSP00000110998","abundance":288,"rank":427,"name":"Eif4a2","annotation":"Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon; Belongs to the DEAD box helicase family. eIF4A subfamily."},{"id":"ENSMUSP00000032399","abundance":288,"rank":428,"name":"Kras","annotation":"GTPase KRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation. Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity)."},{"id":"ENSMUSP00000054634","abundance":287,"rank":429,"name":"Cdc42","annotation":"Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In its active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration (By similarity). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Req [...] "},{"id":"ENSMUSP00000034049","abundance":286,"rank":430,"name":"Slc25a4","annotation":"ADP/ATP translocase 1; Involved in mitochondrial ADP/ATP transport. Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000133815","abundance":284,"rank":431,"name":"Hspa1b","annotation":"Heat shock 70 kDa protein 1B; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and AD [...] "},{"id":"ENSMUSP00000102622","abundance":284,"rank":432,"name":"Arf2","annotation":"ADP-ribosylation factor 2; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus; Belongs to the small GTPase superfamily. Arf family."},{"id":"ENSMUSP00000114076","abundance":284,"rank":433,"name":"Igf2","annotation":"Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity (Probable). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable). IGF-II is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liv [...] "},{"id":"ENSMUSP00000103007","abundance":284,"rank":434,"name":"Idh2","annotation":"Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex; Belongs to the isocitrate and isopropylmalate dehydrogenases family."},{"id":"ENSMUSP00000082652","abundance":284,"rank":435,"name":"Anp32a","annotation":"Acidic leucine-rich nuclear phosphoprotein 32 family member A; Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression; Belongs to the ANP32 family."},{"id":"ENSMUSP00000029445","abundance":283,"rank":436,"name":"Nras","annotation":"GTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family."},{"id":"ENSMUSP00000107760","abundance":283,"rank":437,"name":"Pzp","annotation":"Alpha-2-macroglobulin 165 kDa subunit; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed an [...] "},{"id":"ENSMUSP00000110532","abundance":283,"rank":438,"name":"Rps10","annotation":"40S ribosomal protein S10; Component of the 40S ribosomal subunit."},{"id":"ENSMUSP00000141377","abundance":283,"rank":439,"name":"Gm6525","annotation":"Predicted pseudogene 6525."},{"id":"ENSMUSP00000109692","abundance":283,"rank":440,"name":"Pls3","annotation":"Plastin-3; Actin-bundling protein."},{"id":"ENSMUSP00000030739","abundance":281,"rank":441,"name":"Epb41","annotation":"Protein 4.1; Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase."},{"id":"ENSMUSP00000113525","abundance":279,"rank":442,"name":"Vps29","annotation":"Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] "},{"id":"ENSMUSP00000007248","abundance":278,"rank":443,"name":"Hspa1l","annotation":"Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] "},{"id":"ENSMUSP00000080996","abundance":278,"rank":444,"name":"mt-Atp6","annotation":"ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] "},{"id":"ENSMUSP00000101813","abundance":278,"rank":445,"name":"Ndufs5","annotation":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000047960","abundance":278,"rank":446,"name":"Atp5l","annotation":"ATP synthase subunit g, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] "},{"id":"ENSMUSP00000155898","abundance":277,"rank":447,"name":"Fetub","annotation":"Fetuin-B; Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening. Belongs to the fetuin family."},{"id":"ENSMUSP00000099420","abundance":277,"rank":448,"name":"Krt10","annotation":"Keratin, type I cytoskeletal 10; Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Belongs to the intermediate filament family."},{"id":"ENSMUSP00000023952","abundance":276,"rank":449,"name":"Krt8","annotation":"Keratin, type II cytoskeletal 8; Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000147928","abundance":276,"rank":450,"name":"Rnh1","annotation":"Ribonuclease inhibitor; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity)."},{"id":"ENSMUSP00000028059","abundance":276,"rank":451,"name":"Rsu1","annotation":"Ras suppressor protein 1; Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro."},{"id":"ENSMUSP00000053145","abundance":275,"rank":452,"name":"Uqcrq","annotation":"Cytochrome b-c1 complex subunit 8; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] "},{"id":"ENSMUSP00000032309","abundance":275,"rank":453,"name":"Ybx3","annotation":"Y-box-binding protein 3; Binds to the GM-CSF promoter. Seems to act as a repressor (By similarity). Binds also to full-length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression."},{"id":"ENSMUSP00000058368","abundance":274,"rank":454,"name":"Rpl18a","annotation":"60S ribosomal protein L18a."},{"id":"ENSMUSP00000018437","abundance":273,"rank":455,"name":"Pfn1","annotation":"Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Inhibits androgen receptor (AR) and HTT aggregation and binding of G-actin is essential for its inhibition of AR (By similarity)."},{"id":"ENSMUSP00000099584","abundance":272,"rank":456,"name":"Arpc3","annotation":"Actin-related protein 2/3 complex subunit 3; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA [...] "},{"id":"ENSMUSP00000033800","abundance":271,"rank":457,"name":"Plp1","annotation":"Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family."},{"id":"ENSMUSP00000023589","abundance":271,"rank":458,"name":"Kng1","annotation":"Kininogen-1 heavy chain; (1) Kininogens are inhibitors of thiol proteases; (2) HMW- kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of  [...] "},{"id":"ENSMUSP00000023709","abundance":269,"rank":459,"name":"Krt5","annotation":"Keratin, type II cytoskeletal 5."},{"id":"ENSMUSP00000030164","abundance":269,"rank":460,"name":"Vcp","annotation":"Transitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] "},{"id":"ENSMUSP00000009234","abundance":267,"rank":461,"name":"Ap1b1","annotation":"AP-1 complex subunit beta-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules."},{"id":"ENSMUSP00000109451","abundance":266,"rank":462,"name":"Arpc2","annotation":"Actin-related protein 2/3 complex subunit 2; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promot [...] "},{"id":"ENSMUSP00000141648","abundance":266,"rank":463,"name":"Fgg","annotation":"Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not abs [...] "},{"id":"ENSMUSP00000066238","abundance":263,"rank":464,"name":"Rap1b","annotation":"Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family."},{"id":"ENSMUSP00000076521","abundance":262,"rank":465,"name":"Pdia4","annotation":"Protein disulfide-isomerase A4."},{"id":"ENSMUSP00000071976","abundance":259,"rank":466,"name":"Try10","annotation":"Trypsinogen 10; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000005860","abundance":257,"rank":467,"name":"Pvalb","annotation":"Parvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; Belongs to the parvalbumin family."},{"id":"ENSMUSP00000029699","abundance":257,"rank":468,"name":"Lmna","annotation":"Prelamin-A/C; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. A [...] "},{"id":"ENSMUSP00000103012","abundance":256,"rank":469,"name":"Acly","annotation":"ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family."},{"id":"ENSMUSP00000111443","abundance":256,"rank":470,"name":"Ube2v2","annotation":"Ubiquitin-conjugating enzyme E2 variant 2; Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly- ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage."},{"id":"ENSMUSP00000107768","abundance":256,"rank":471,"name":"Dync1i2","annotation":"Cytoplasmic dynein 1 intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity)."},{"id":"ENSMUSP00000060346","abundance":256,"rank":472,"name":"Dlst","annotation":"2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase); Dihydrolipoamide succinyltransferase (E2) component of the 2- oxoglutarate dehydrogenase complex (By similarity). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2- oxoglutarate to succinyl-CoA and CO(2) (By similarity). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and p [...] "},{"id":"ENSMUSP00000064280","abundance":256,"rank":473,"name":"Dlg1","annotation":"Disks large homolog 1; Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels (By similarity). Functional regulator of Kv1.5 channel (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. During long-term depression in hippocampal neurons, it recruits ADAM10 to the pl [...] "},{"id":"ENSMUSP00000113945","abundance":255,"rank":474,"name":"Serpina3f","annotation":"Serine protease inhibitor A3F; Belongs to the serpin family."},{"id":"ENSMUSP00000021950","abundance":254,"rank":475,"name":"Dbn1","annotation":"Drebrin; Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Required for actin polymerization at immunological synapses (IS) and for the recruitment of the chemokine receptor CXCR4 to IS (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines. Involved in memory-related synaptic plasticity in the hippocampus."},{"id":"ENSMUSP00000037597","abundance":254,"rank":476,"name":"Snrpd2","annotation":"Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome."},{"id":"ENSMUSP00000080469","abundance":253,"rank":477,"name":"Mug2","annotation":"Murinoglobulin-2; A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, f [...] "},{"id":"ENSMUSP00000100655","abundance":253,"rank":478,"name":"Gm3550","annotation":"60S ribosomal protein L29; Belongs to the eukaryotic ribosomal protein eL29 family."},{"id":"ENSMUSP00000104700","abundance":253,"rank":479,"name":"Skp1a","annotation":"S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] "},{"id":"ENSMUSP00000007959","abundance":253,"rank":480,"name":"Rhoa","annotation":"Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (By similarity). [...] "},{"id":"ENSMUSP00000115722","abundance":252,"rank":481,"name":"Rpl13a","annotation":"60S ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (By similarity). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as cerupla [...] "},{"id":"ENSMUSP00000033741","abundance":251,"rank":482,"name":"Bgn","annotation":"Biglycan; May be involved in collagen fiber assembly; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily."},{"id":"ENSMUSP00000021273","abundance":250,"rank":483,"name":"Vamp2","annotation":"Vesicle-associated membrane protein 2; Involved in the targeting and/or fusion of transport vesicles to their target membrane. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (By similarity); Belongs to the synaptobrevin family."},{"id":"ENSMUSP00000070368","abundance":248,"rank":484,"name":"Amy1","annotation":"Alpha-amylase 1."},{"id":"ENSMUSP00000111946","abundance":248,"rank":485,"name":"Hk1","annotation":"Hexokinase-1; Catalyzes the phosphorylation of various hexoses, such as D- glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6- phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor f [...] "},{"id":"ENSMUSP00000047564","abundance":246,"rank":486,"name":"Pygm","annotation":"Glycogen phosphorylase, muscle form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties."},{"id":"ENSMUSP00000038505","abundance":246,"rank":487,"name":"Polr2j","annotation":"DNA-directed RNA polymerase II subunit RPB11; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity)."},{"id":"ENSMUSP00000018186","abundance":241,"rank":488,"name":"Cyb5r3","annotation":"NADH-cytochrome b5 reductase 3 membrane-bound form; Desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction."},{"id":"ENSMUSP00000156883","abundance":241,"rank":489,"name":"Gm49909","annotation":"Predicted gene, 49909."},{"id":"ENSMUSP00000042364","abundance":241,"rank":490,"name":"Myl12b","annotation":"Myosin regulatory light chain 12B; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion."},{"id":"ENSMUSP00000032998","abundance":241,"rank":491,"name":"Rps3","annotation":"40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit (By similarity). Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (By similarity). Displays high binding affinity for 7,8-dihydro-8- oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (By similarity). Has also been shown to bind with similar affinity to intact and damaged DNA (By similarity). S [...] "},{"id":"ENSMUSP00000110678","abundance":240,"rank":492,"name":"Cald1","annotation":"Caldesmon 1."},{"id":"ENSMUSP00000051223","abundance":240,"rank":493,"name":"Ywhag","annotation":"14-3-3 protein gamma, N-terminally processed; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner."},{"id":"ENSMUSP00000129730","abundance":240,"rank":494,"name":"Dnaja1","annotation":"DnaJ homolog subfamily A member 1; Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (By similarity). Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis."},{"id":"ENSMUSP00000143608","abundance":239,"rank":495,"name":"Ube2d3","annotation":"Ubiquitin-conjugating enzyme E2 D3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed [...] "},{"id":"ENSMUSP00000132446","abundance":239,"rank":496,"name":"Ube2d2a","annotation":"Ubiquitin-conjugating enzyme E2 D2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Mediates the selective degradation of short- lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of  [...] "},{"id":"ENSMUSP00000031971","abundance":239,"rank":497,"name":"Ssbp1","annotation":"Single-stranded DNA-binding protein, mitochondrial; Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays crucial roles during mtDNA replication that stimulate activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5 [...] "},{"id":"ENSMUSP00000144235","abundance":238,"rank":498,"name":"Sept11","annotation":"Septin-11; Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). May play a role in the cytoarchitecture of neurons, including dendritic arborization and dendritic spines, and in GABAergic synaptic connectivity (By similarity); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family."},{"id":"ENSMUSP00000129767","abundance":237,"rank":499,"name":"Psma2","annotation":"Proteasome subunit alpha type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] "},{"id":"ENSMUSP00000111120","abundance":235,"rank":500,"name":"Eif4g1","annotation":"Eukaryotic translation initiation factor 4 gamma 1; Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome."},{"id":"ENSMUSP00000075150","abundance":235,"rank":501,"name":"Cox6b1","annotation":"Cytochrome c oxidase subunit 6B1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and [...] "},{"id":"ENSMUSP00000151972","abundance":234,"rank":502,"name":"Nap1l1","annotation":"Nucleosome assembly protein 1-like 1; Plays a key role in the regulation of embryonic neurogenesis. Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development. Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter. Belongs to the nucleosome assembly protein (NAP) family."},{"id":"ENSMUSP00000027067","abundance":234,"rank":503,"name":"Gsta3","annotation":"Glutathione S-transferase A3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This GST has a high catalytic activity for aflatoxin B1-8,9 epoxide."},{"id":"ENSMUSP00000078715","abundance":234,"rank":504,"name":"Myl3","annotation":"Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium."},{"id":"ENSMUSP00000058919","abundance":232,"rank":505,"name":"Rpl37a","annotation":"60S ribosomal protein L37a; Belongs to the eukaryotic ribosomal protein eL43 family."},{"id":"ENSMUSP00000127641","abundance":232,"rank":506,"name":"Sept7","annotation":"Septin-7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity)."},{"id":"ENSMUSP00000128489","abundance":232,"rank":507,"name":"Gm6133","annotation":"Predicted gene 6133; Belongs to the universal ribosomal protein uL22 family."},{"id":"ENSMUSP00000102559","abundance":231,"rank":508,"name":"Ak4","annotation":"Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular r [...] "},{"id":"ENSMUSP00000099409","abundance":231,"rank":509,"name":"Cnp","annotation":"2',3'-cyclic-nucleotide 3'-phosphodiesterase; May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin."},{"id":"ENSMUSP00000096912","abundance":230,"rank":510,"name":"Bhmt","annotation":"Betaine--homocysteine S-methyltransferase 1; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline."},{"id":"ENSMUSP00000135956","abundance":230,"rank":511,"name":"Gm5096","annotation":"Predicted gene 5096."},{"id":"ENSMUSP00000023788","abundance":230,"rank":512,"name":"Krt6a","annotation":"Keratin, type II cytoskeletal 6A; Epidermis-specific type I keratin involved in wound healing. Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration. Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair. Belongs to the intermediate filament family."},{"id":"ENSMUSP00000009036","abundance":229,"rank":513,"name":"Vdac3","annotation":"Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules."},{"id":"ENSMUSP00000077612","abundance":229,"rank":514,"name":"C1qbp","annotation":"Complement component 1 Q subcomponent-binding protein, mitochondrial; Is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a [...] "},{"id":"ENSMUSP00000112798","abundance":228,"rank":515,"name":"Itih4","annotation":"Inter alpha-trypsin inhibitor, heavy chain 4; Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration."},{"id":"ENSMUSP00000137210","abundance":228,"rank":516,"name":"Gm9844","annotation":"Predicted pseudogene 9844."},{"id":"ENSMUSP00000109683","abundance":228,"rank":517,"name":"Tmsb10","annotation":"Thymosin beta-10; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Belongs to the thymosin beta family."},{"id":"ENSMUSP00000113022","abundance":228,"rank":518,"name":"Atp5pb","annotation":"ATP synthase F(0) complex subunit B1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechani [...] "},{"id":"ENSMUSP00000114839","abundance":228,"rank":519,"name":"Arpc4","annotation":"Actin-related protein 2/3 complex subunit 4; Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in r [...] "},{"id":"ENSMUSP00000063825","abundance":227,"rank":520,"name":"Pcx","annotation":"Pyruvate carboxylase, mitochondrial; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate."},{"id":"ENSMUSP00000106874","abundance":227,"rank":521,"name":"Atp1a4","annotation":"Sodium/potassium-transporting ATPase subunit alpha-4; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily."},{"id":"ENSMUSP00000104229","abundance":227,"rank":522,"name":"Dlg4","annotation":"Disks large homolog 4; Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated stat [...] "},{"id":"ENSMUSP00000046557","abundance":225,"rank":523,"name":"Gng12","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000145242","abundance":225,"rank":524,"name":"Gm7298","annotation":"Predicted gene 7298."},{"id":"ENSMUSP00000018875","abundance":224,"rank":525,"name":"Ap2b1","annotation":"AP-2 complex subunit beta; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but [...] "},{"id":"ENSMUSP00000001042","abundance":224,"rank":526,"name":"Ilf2","annotation":"Interleukin enhancer-binding factor 2; Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). Essential for the efficient reshuttling of ILF3 into the nucleus (By similarity)."},{"id":"ENSMUSP00000079699","abundance":223,"rank":527,"name":"Krt17","annotation":"Keratin, type I cytoskeletal 17; Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epit [...] "},{"id":"ENSMUSP00000079356","abundance":223,"rank":528,"name":"H1f5","annotation":"Histone H1.5; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)."},{"id":"ENSMUSP00000088174","abundance":223,"rank":529,"name":"Rap1a","annotation":"Ras-related protein Rap-1A; Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular  [...] "},{"id":"ENSMUSP00000115419","abundance":222,"rank":530,"name":"Cox7c","annotation":"Cytochrome c oxidase subunit 7C, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] "},{"id":"ENSMUSP00000101864","abundance":220,"rank":531,"name":"Cap1","annotation":"Adenylyl cyclase-associated protein 1; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity."},{"id":"ENSMUSP00000000317","abundance":220,"rank":532,"name":"Ckmt1","annotation":"Creatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family."},{"id":"ENSMUSP00000123412","abundance":219,"rank":533,"name":"Myl12a","annotation":"Myosin, light chain 12A, regulatory, non-sarcomeric."},{"id":"ENSMUSP00000125504","abundance":219,"rank":534,"name":"Atp5j2","annotation":"ATP synthase subunit f, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] "},{"id":"ENSMUSP00000133428","abundance":219,"rank":535,"name":"Ddx39b","annotation":"Spliceosome RNA helicase Ddx39b; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pat [...] "},{"id":"ENSMUSP00000020077","abundance":219,"rank":536,"name":"Lims1","annotation":"LIM and senescent cell antigen-like-containing domain protein 1; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation."},{"id":"ENSMUSP00000098058","abundance":219,"rank":537,"name":"Rac1","annotation":"Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity  [...] "},{"id":"ENSMUSP00000026459","abundance":216,"rank":538,"name":"Atp5b","annotation":"ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] "},{"id":"ENSMUSP00000112081","abundance":216,"rank":539,"name":"Rpn2","annotation":"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] "},{"id":"ENSMUSP00000066138","abundance":216,"rank":540,"name":"Ubap2l","annotation":"Ubiquitin-associated protein 2-like; Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs)."},{"id":"ENSMUSP00000029046","abundance":214,"rank":541,"name":"Fabp5","annotation":"Fatty acid-binding protein 5; Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses a [...] "},{"id":"ENSMUSP00000158496","abundance":214,"rank":542,"name":"Paip2","annotation":"Polyadenylate-binding protein-interacting protein 2; Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization (By similarity). Belongs to the PAIP2 family."},{"id":"ENSMUSP00000099534","abundance":214,"rank":543,"name":"B2m","annotation":"Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system; Belongs to the beta-2-microglobulin family."},{"id":"ENSMUSP00000030412","abundance":211,"rank":544,"name":"Ppt1","annotation":"Palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons."},{"id":"ENSMUSP00000019109","abundance":211,"rank":545,"name":"Ywhah","annotation":"14-3-3 protein eta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)."},{"id":"ENSMUSP00000037304","abundance":210,"rank":546,"name":"H1f6","annotation":"Histone H1t; Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration."},{"id":"ENSMUSP00000130145","abundance":209,"rank":547,"name":"Fubp1","annotation":"Far upstream element-binding protein 1; Regulates MYC expression by binding to a single-stranded far- upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (By similarity)."},{"id":"ENSMUSP00000026561","abundance":209,"rank":548,"name":"Cox8b","annotation":"Cytochrome c oxidase subunit 8B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] "},{"id":"ENSMUSP00000109907","abundance":209,"rank":549,"name":"Snca","annotation":"Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs  [...] "},{"id":"ENSMUSP00000155155","abundance":209,"rank":550,"name":"Dnm1l","annotation":"Dynamin-1-like protein; Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP- dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1 [...] "},{"id":"ENSMUSP00000110021","abundance":209,"rank":551,"name":"Rab11b","annotation":"Ras-related protein Rab-11B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regul [...] "},{"id":"ENSMUSP00000081141","abundance":208,"rank":552,"name":"Pgd","annotation":"6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH."},{"id":"ENSMUSP00000033720","abundance":208,"rank":553,"name":"Rbbp7","annotation":"Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and [...] "},{"id":"ENSMUSP00000143910","abundance":208,"rank":554,"name":"Eif4h","annotation":"Eukaryotic translation initiation factor 4H; Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA (By similarity)."},{"id":"ENSMUSP00000046059","abundance":206,"rank":555,"name":"Myh14","annotation":"Myosin-14; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000022163","abundance":206,"rank":556,"name":"Btf3","annotation":"Transcription factor BTF3; When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription (By similarity); Belongs to the NAC-beta family."},{"id":"ENSMUSP00000008594","abundance":206,"rank":557,"name":"Nutf2","annotation":"Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import."},{"id":"ENSMUSP00000131850","abundance":206,"rank":558,"name":"Nutf2-ps1","annotation":"Nuclear transport factor 2, pseudogene 1."},{"id":"ENSMUSP00000118169","abundance":205,"rank":559,"name":"Lgals3","annotation":"Galectin-3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage [...] "},{"id":"ENSMUSP00000110894","abundance":204,"rank":560,"name":"Sept6","annotation":"Septin-6; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family."},{"id":"ENSMUSP00000138399","abundance":203,"rank":561,"name":"Hnrnpr","annotation":"Heterogeneous nuclear ribonucleoprotein R."},{"id":"ENSMUSP00000047571","abundance":203,"rank":562,"name":"Hnrnpu","annotation":"Heterogeneous nuclear ribonucleoprotein U; DNA- and RNA-binding protein involved in several cellular processes such as nuclear chromatin organization, telomere-length regulation, transcription, mRNA alternative splicing and stability, Xist-mediated transcriptional silencing and mitotic cell progression. Plays a role in the regulation of interphase large-scale gene-rich chromatin organization through chromatin-associated RNAs (caRNAs) in a transcription-dependent manner, and thereby maintains genomic stability (By similarity). Required for the localization of the long non-coding Xist RN [...] "},{"id":"ENSMUSP00000071636","abundance":203,"rank":563,"name":"Prdx6","annotation":"Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role  [...] "},{"id":"ENSMUSP00000000090","abundance":202,"rank":564,"name":"Cox5a","annotation":"Cytochrome c oxidase subunit 5A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] "},{"id":"ENSMUSP00000089051","abundance":202,"rank":565,"name":"Stxbp1","annotation":"Syntaxin-binding protein 1; Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity); Belongs to the STXBP/unc-18/SEC1 family."},{"id":"ENSMUSP00000037206","abundance":201,"rank":566,"name":"Fkbp1a","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP1A; Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP [...] "},{"id":"ENSMUSP00000133564","abundance":200,"rank":567,"name":"Dnm2","annotation":"Dynamin-2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane."},{"id":"ENSMUSP00000028517","abundance":200,"rank":568,"name":"Ola1","annotation":"Obg-like ATPase 1; Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP."},{"id":"ENSMUSP00000019911","abundance":200,"rank":569,"name":"Hdac2","annotation":"Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor co [...] "},{"id":"ENSMUSP00000023786","abundance":197,"rank":570,"name":"Krt6b","annotation":"Keratin, type II cytoskeletal 6B; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000065349","abundance":197,"rank":571,"name":"Krt73","annotation":"Keratin, type II cytoskeletal 73; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)."},{"id":"ENSMUSP00000003912","abundance":196,"rank":572,"name":"Calr","annotation":"Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity); Belongs to the calreticulin family."},{"id":"ENSMUSP00000129163","abundance":195,"rank":573,"name":"Rab11a","annotation":"Ras-related protein Rab-11A; The small GTPases Rab areR key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial  [...] "},{"id":"ENSMUSP00000119150","abundance":194,"rank":574,"name":"Saa1","annotation":"Serum amyloid A-1 protein; Major acute phase protein."},{"id":"ENSMUSP00000085913","abundance":193,"rank":575,"name":"Myl9","annotation":"Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion."},{"id":"ENSMUSP00000051268","abundance":193,"rank":576,"name":"Echdc2","annotation":"Enoyl-CoA hydratase domain-containing protein 2, mitochondrial; Belongs to the enoyl-CoA hydratase/isomerase family."},{"id":"ENSMUSP00000116492","abundance":192,"rank":577,"name":"Eef1b2","annotation":"Elongation factor 1-beta; EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP."},{"id":"ENSMUSP00000079228","abundance":192,"rank":578,"name":"Snrpa","annotation":"U1 small nuclear ribonucleoprotein A; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs (By similarity)."},{"id":"ENSMUSP00000124480","abundance":191,"rank":579,"name":"Cyb5a","annotation":"Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. It is also involved in several steps of the sterol biosynthesis pathway, particularly in the C-5 double bond introduction during the C-5 desaturation."},{"id":"ENSMUSP00000110374","abundance":190,"rank":580,"name":"Rbmx","annotation":"RNA-binding motif protein, X chromosome, N-terminally processed; RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue- specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the suprasplic [...] "},{"id":"ENSMUSP00000020203","abundance":190,"rank":581,"name":"Snrpf","annotation":"Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing."},{"id":"ENSMUSP00000120595","abundance":189,"rank":582,"name":"Srsf1","annotation":"Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...] "},{"id":"ENSMUSP00000001304","abundance":188,"rank":583,"name":"Ckb","annotation":"Creatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family."},{"id":"ENSMUSP00000127526","abundance":187,"rank":584,"name":"Idh3a","annotation":"Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers."},{"id":"ENSMUSP00000028238","abundance":186,"rank":585,"name":"Rab14","annotation":"Ras-related protein Rab-14; Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N- cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B [...] "},{"id":"ENSMUSP00000152454","abundance":185,"rank":586,"name":"Gdi2","annotation":"Rab GDP dissociation inhibitor beta; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them."},{"id":"ENSMUSP00000095169","abundance":185,"rank":587,"name":"Csrp1","annotation":"Cysteine and glycine-rich protein 1; Could play a role in neuronal development."},{"id":"ENSMUSP00000021001","abundance":184,"rank":588,"name":"Rab10","annotation":"Ras-related protein Rab-10; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab is mainly involved in the biosynthetic transport of proteins from the Golgi to the plasma membrane (By similarity). Regulates, for instance, SLC [...] "},{"id":"ENSMUSP00000029155","abundance":184,"rank":589,"name":"Epb41l1","annotation":"Band 4.1-like protein 1; May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases."},{"id":"ENSMUSP00000110229","abundance":184,"rank":590,"name":"Hmgb3","annotation":"High mobility group protein B3; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor. Negatively regulates B-cell and myeloid cel [...] "},{"id":"ENSMUSP00000015950","abundance":184,"rank":591,"name":"Qdpr","annotation":"Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000096549","abundance":183,"rank":592,"name":"Elavl1","annotation":"ELAV-like protein 1; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU- rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds [...] "},{"id":"ENSMUSP00000104957","abundance":182,"rank":593,"name":"Mrps36","annotation":"28S ribosomal protein S36, mitochondrial."},{"id":"ENSMUSP00000021018","abundance":182,"rank":594,"name":"Taf15","annotation":"TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor."},{"id":"ENSMUSP00000036246","abundance":181,"rank":595,"name":"Krt75","annotation":"Keratin, type II cytoskeletal 75; Plays a central role in hair and nail formation. Essential component of keratin intermediate filaments in the companion layer of the hair follicle (By similarity)."},{"id":"ENSMUSP00000123609","abundance":181,"rank":596,"name":"Cox6c","annotation":"Cytochrome c oxidase subunit 6C; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and  [...] "},{"id":"ENSMUSP00000096932","abundance":180,"rank":597,"name":"Ube2n","annotation":"Ubiquitin-conjugating enzyme E2 N; The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of P [...] "},{"id":"ENSMUSP00000088057","abundance":180,"rank":598,"name":"Psma5","annotation":"Proteasome subunit alpha type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] "},{"id":"ENSMUSP00000096829","abundance":180,"rank":599,"name":"Csnk2a1","annotation":"Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] "},{"id":"ENSMUSP00000048153","abundance":180,"rank":600,"name":"Rbmxl1","annotation":"RNA binding motif protein, X-linked-like-1; RNA-binding protein which may be involved in pre-mRNA splicing."},{"id":"ENSMUSP00000030651","abundance":180,"rank":601,"name":"Sh3bgrl3","annotation":"SH3 domain-binding glutamic acid-rich-like protein 3; Could act as a modulator of glutaredoxin biological activity."},{"id":"ENSMUSP00000088249","abundance":178,"rank":602,"name":"Hmgcs2","annotation":"Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase."},{"id":"ENSMUSP00000142767","abundance":178,"rank":603,"name":"Gm7879","annotation":"Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family."},{"id":"ENSMUSP00000002303","abundance":178,"rank":604,"name":"Rhoc","annotation":"Rho-related GTP-binding protein RhoC; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells. Belongs to the small GTPase superfamily. Rho family."},{"id":"ENSMUSP00000146972","abundance":177,"rank":605,"name":"Ckm","annotation":"Creatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family."},{"id":"ENSMUSP00000105719","abundance":177,"rank":606,"name":"Rab3a","annotation":"Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimula [...] "},{"id":"ENSMUSP00000055254","abundance":176,"rank":607,"name":"Luc7l2","annotation":"Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain."},{"id":"ENSMUSP00000023851","abundance":176,"rank":608,"name":"Ndufa5","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000154633","abundance":176,"rank":609,"name":"Gm7324","annotation":"Predicted gene 7324."},{"id":"ENSMUSP00000049338","abundance":176,"rank":610,"name":"Nipsnap1","annotation":"Protein NipSnap homolog 1; Belongs to the NipSnap family."},{"id":"ENSMUSP00000020002","abundance":176,"rank":611,"name":"Abracl","annotation":"Costars family protein ABRACL; Belongs to the costars family."},{"id":"ENSMUSP00000112843","abundance":176,"rank":612,"name":"S100a9","annotation":"Protein S100-A9; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid [...] "},{"id":"ENSMUSP00000019317","abundance":175,"rank":613,"name":"Rab5c","annotation":"Ras-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000099950","abundance":175,"rank":614,"name":"Sardh","annotation":"Sarcosine dehydrogenase, mitochondrial; Belongs to the GcvT family."},{"id":"ENSMUSP00000104884","abundance":175,"rank":615,"name":"Clint1","annotation":"Clathrin interactor 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly (By similarity); Belongs to the epsin family."},{"id":"ENSMUSP00000009157","abundance":175,"rank":616,"name":"Dynll1","annotation":"Dynein light chain 1, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1; Belongs to th [...] "},{"id":"ENSMUSP00000023123","abundance":174,"rank":617,"name":"Col2a1","annotation":"Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces."},{"id":"ENSMUSP00000034947","abundance":173,"rank":618,"name":"Ppib","annotation":"Peptidyl-prolyl cis-trans isomerase B; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding; Belongs to the cyclophilin-type PPIase family. PPIase B subfamily."},{"id":"ENSMUSP00000007799","abundance":173,"rank":619,"name":"Cav1","annotation":"Caveolin-1; May act as a scaffolding protein within caveolar membranes (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] "},{"id":"ENSMUSP00000138884","abundance":173,"rank":620,"name":"Gm15013","annotation":"40S ribosomal protein S4; Belongs to the eukaryotic ribosomal protein eS4 family."},{"id":"ENSMUSP00000068479","abundance":173,"rank":621,"name":"Ak1","annotation":"Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also possesses broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). May provide a mechanism to buffer the adenylate energy charge for sperm motility."},{"id":"ENSMUSP00000032856","abundance":173,"rank":622,"name":"Me3","annotation":"NADP-dependent malic enzyme, mitochondrial; Belongs to the malic enzymes family."},{"id":"ENSMUSP00000028610","abundance":171,"rank":623,"name":"Cat","annotation":"Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family."},{"id":"ENSMUSP00000113126","abundance":171,"rank":624,"name":"Apoc3","annotation":"Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] "},{"id":"ENSMUSP00000027438","abundance":171,"rank":625,"name":"Ncl","annotation":"Nucleolin; Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG- 3' repeats more tightly than the telomeric single-stranded DNA 5'- TTAGGG-3' repeats (By similarity)."},{"id":"ENSMUSP00000031160","abundance":170,"rank":626,"name":"Paics","annotation":"Phosphoribosylaminoimidazole-succinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily."},{"id":"ENSMUSP00000077262","abundance":170,"rank":627,"name":"Cfl2","annotation":"Cofilin-2; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere."},{"id":"ENSMUSP00000003121","abundance":170,"rank":628,"name":"Rab8a","annotation":"Ras-related protein Rab-8A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes t [...] "},{"id":"ENSMUSP00000033673","abundance":168,"rank":629,"name":"Nono","annotation":"Non-POU domain-containing octamer-binding protein; DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclea [...] "},{"id":"ENSMUSP00000152074","abundance":168,"rank":630,"name":"Gm20075","annotation":"Predicted gene, 20075."},{"id":"ENSMUSP00000099803","abundance":168,"rank":631,"name":"Btf3l4","annotation":"Transcription factor BTF3 homolog 4; Belongs to the NAC-beta family."},{"id":"ENSMUSP00000054863","abundance":167,"rank":632,"name":"Pcbp1","annotation":"Poly(rC)-binding protein 1; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC."},{"id":"ENSMUSP00000095656","abundance":167,"rank":633,"name":"Tufm","annotation":"Elongation factor Tu, mitochondrial; Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG- I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily."},{"id":"ENSMUSP00000061851","abundance":167,"rank":634,"name":"Ahcy","annotation":"Adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine."},{"id":"ENSMUSP00000127198","abundance":167,"rank":635,"name":"Gm4737","annotation":"Predicted gene 4737."},{"id":"ENSMUSP00000032344","abundance":167,"rank":636,"name":"Arhgdib","annotation":"Rho GDP-dissociation inhibitor 2; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members."},{"id":"ENSMUSP00000093955","abundance":166,"rank":637,"name":"Eef1g","annotation":"Elongation factor 1-gamma; Probably plays a role in anchoring the complex to other cellular components."},{"id":"ENSMUSP00000104069","abundance":164,"rank":638,"name":"Myo1c","annotation":"Unconventional myosin-Ic; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4- containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of ve [...] "},{"id":"ENSMUSP00000015667","abundance":164,"rank":639,"name":"Ctss","annotation":"Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000106481","abundance":163,"rank":640,"name":"Dld","annotation":"Dihydrolipoyl dehydrogenase, mitochondrial; Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched- chain amino acid-dehydrogenase complex) (By similarity). The 2- oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (By similarity). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA t [...] "},{"id":"ENSMUSP00000136035","abundance":163,"rank":641,"name":"Gyg","annotation":"Glycogenin-1; Self-glucosylates, via an inter-subunit mechanism, to form an oligosaccharide primer that serves as substrate for glycogen synthase."},{"id":"ENSMUSP00000029266","abundance":163,"rank":642,"name":"Anxa5","annotation":"Annexin A5; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade; Belongs to the annexin family."},{"id":"ENSMUSP00000030797","abundance":162,"rank":643,"name":"Vamp3","annotation":"Vesicle-associated membrane protein 3; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the synaptobrevin family."},{"id":"ENSMUSP00000054834","abundance":162,"rank":644,"name":"Tmed2","annotation":"Transmembrane emp24 domain-containing protein 2; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle- mediated anterograde transport involved in the transport of GPI- anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of th [...] "},{"id":"ENSMUSP00000004375","abundance":162,"rank":645,"name":"Phb2","annotation":"Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Belongs to the prohibitin family."},{"id":"ENSMUSP00000032910","abundance":161,"rank":646,"name":"Mylpf","annotation":"Myosin regulatory light chain 2, skeletal muscle isoform."},{"id":"ENSMUSP00000004140","abundance":160,"rank":647,"name":"Gstm1","annotation":"Glutathione S-transferase Mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles."},{"id":"ENSMUSP00000035158","abundance":160,"rank":648,"name":"Trf","annotation":"Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation."},{"id":"ENSMUSP00000093965","abundance":160,"rank":649,"name":"Ganab","annotation":"Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia."},{"id":"ENSMUSP00000031423","abundance":160,"rank":650,"name":"Atp2a2","annotation":"Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] "},{"id":"ENSMUSP00000019323","abundance":159,"rank":651,"name":"Mdh2","annotation":"Malate dehydrogenase, mitochondrial."},{"id":"ENSMUSP00000099658","abundance":159,"rank":652,"name":"Rbbp4","annotation":"Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome re [...] "},{"id":"ENSMUSP00000026428","abundance":159,"rank":653,"name":"Myl6b","annotation":"Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium."},{"id":"ENSMUSP00000026667","abundance":158,"rank":654,"name":"Eif4a3","annotation":"Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] "},{"id":"ENSMUSP00000026125","abundance":158,"rank":655,"name":"Alyref","annotation":"THO complex subunit 4; Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription- independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a regio [...] "},{"id":"ENSMUSP00000025337","abundance":158,"rank":656,"name":"Diaph1","annotation":"Protein diaphanous homolog 1; Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting act [...] "},{"id":"ENSMUSP00000102814","abundance":158,"rank":657,"name":"Dlg2","annotation":"Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses."},{"id":"ENSMUSP00000111309","abundance":157,"rank":658,"name":"Ranbp1","annotation":"Ran-specific GTPase-activating protein; Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle asse [...] "},{"id":"ENSMUSP00000085311","abundance":157,"rank":659,"name":"Krt77","annotation":"Keratin, type II cytoskeletal 1b."},{"id":"ENSMUSP00000030169","abundance":156,"rank":660,"name":"Stoml2","annotation":"Stomatin-like protein 2, mitochondrial; Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. M [...] "},{"id":"ENSMUSP00000096264","abundance":156,"rank":661,"name":"Amy2a2","annotation":"Pancreatic alpha-amylase."},{"id":"ENSMUSP00000136894","abundance":156,"rank":662,"name":"Amy2a3","annotation":"Amylase 2a3."},{"id":"ENSMUSP00000137025","abundance":156,"rank":663,"name":"Amy2a4","annotation":"Amylase 2a4."},{"id":"ENSMUSP00000096270","abundance":156,"rank":664,"name":"Amy2a5","annotation":"Amylase 2a5."},{"id":"ENSMUSP00000072175","abundance":156,"rank":665,"name":"Dnajc5","annotation":"DnaJ homolog subfamily C member 5; Acts as a co-chaperone for the SNARE protein SNAP-25. Involved in the calcium-mediated control of a late stage of exocytosis. Acts as a general chaperone in regulated exocytosis (By similarity). May have an important role in presynaptic function (By similarity). May be involved in calcium- dependent neurotransmitter release at nerve endings (By similarity)."},{"id":"ENSMUSP00000001989","abundance":156,"rank":666,"name":"Uba1","annotation":"Ubiquitin-like modifier-activating enzyme 1; Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites."},{"id":"ENSMUSP00000099933","abundance":155,"rank":667,"name":"Xpo1","annotation":"Exportin-1; Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase Ran in its active GTP-bound form. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from t [...] "},{"id":"ENSMUSP00000056152","abundance":155,"rank":668,"name":"Otc","annotation":"Ornithine carbamoyltransferase, mitochondrial."},{"id":"ENSMUSP00000019939","abundance":155,"rank":669,"name":"Snx3","annotation":"Sorting nexin-3; Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde en [...] "},{"id":"ENSMUSP00000030044","abundance":155,"rank":670,"name":"Orm1","annotation":"Alpha-1-acid glycoprotein 1; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction."},{"id":"ENSMUSP00000007272","abundance":155,"rank":671,"name":"Krt14","annotation":"Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro."},{"id":"ENSMUSP00000107079","abundance":155,"rank":672,"name":"Celf1","annotation":"CUGBP Elav-like family member 1; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition (By similarity). Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion o [...] "},{"id":"ENSMUSP00000082004","abundance":154,"rank":673,"name":"Klc1","annotation":"Kinesin light chain 1; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity."},{"id":"ENSMUSP00000063325","abundance":154,"rank":674,"name":"Acox1","annotation":"Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs (By similarity). Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length (By similarity). Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs (By similarity)."},{"id":"ENSMUSP00000022429","abundance":154,"rank":675,"name":"Arf4","annotation":"ADP-ribosylation factor 4; GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus."},{"id":"ENSMUSP00000022369","abundance":153,"rank":676,"name":"Vcl","annotation":"Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity); Belongs to the vinculin/alpha-catenin family."},{"id":"ENSMUSP00000118566","abundance":153,"rank":677,"name":"Mtch2","annotation":"Mitochondrial carrier homolog 2; The substrate transported is not yet known. Induces mitochondrial depolarization (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000020085","abundance":152,"rank":678,"name":"Ube2d1","annotation":"Ubiquitin-conjugating enzyme E2 D1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Mediates the selective degradation of short- lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto- ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1- associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates pol [...] "},{"id":"ENSMUSP00000041857","abundance":152,"rank":679,"name":"Rab8b","annotation":"Ras-related protein Rab-8B; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells (By similarity)."},{"id":"ENSMUSP00000133844","abundance":151,"rank":680,"name":"Ubtf","annotation":"Nucleolar transcription factor 1; Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element."},{"id":"ENSMUSP00000136358","abundance":151,"rank":681,"name":"Fau","annotation":"Ubiquitin-like protein FUBI; Belongs to the ubiquitin family."},{"id":"ENSMUSP00000029610","abundance":151,"rank":682,"name":"Hadh","annotation":"Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family."},{"id":"ENSMUSP00000001046","abundance":151,"rank":683,"name":"S100a4","annotation":"Protein S100-A4; Belongs to the S-100 family."},{"id":"ENSMUSP00000133523","abundance":151,"rank":684,"name":"Cct4","annotation":"T-complex protein 1 subunit delta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin."},{"id":"ENSMUSP00000030187","abundance":150,"rank":685,"name":"Tln1","annotation":"Talin-1; Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts."},{"id":"ENSMUSP00000028681","abundance":150,"rank":686,"name":"F2","annotation":"Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity)."},{"id":"ENSMUSP00000105216","abundance":150,"rank":687,"name":"Rbm39","annotation":"RNA-binding protein 39; Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1. May be involved in pre- mRNA splicing process; Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000001148","abundance":150,"rank":688,"name":"Pcbp3","annotation":"Poly(rC)-binding protein 3; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC."},{"id":"ENSMUSP00000120115","abundance":150,"rank":689,"name":"Hnrnpm","annotation":"Heterogeneous nuclear ribonucleoprotein M; Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines (By similarity)."},{"id":"ENSMUSP00000065983","abundance":150,"rank":690,"name":"Mapk1","annotation":"Mitogen-activated protein kinase 1; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] "},{"id":"ENSMUSP00000023677","abundance":149,"rank":691,"name":"Atp5o","annotation":"ATP synthase subunit O, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the centr [...] "},{"id":"ENSMUSP00000077744","abundance":149,"rank":692,"name":"Uqcrh","annotation":"Cytochrome b-c1 complex subunit 6, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradie [...] "},{"id":"ENSMUSP00000114705","abundance":149,"rank":693,"name":"Dbi","annotation":"Acyl-CoA-binding protein; Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor."},{"id":"ENSMUSP00000020717","abundance":149,"rank":694,"name":"Arf5","annotation":"ADP-ribosylation factor 5; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus."},{"id":"ENSMUSP00000022097","abundance":149,"rank":695,"name":"Ndufs6","annotation":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000148550","abundance":148,"rank":696,"name":"Gnao1","annotation":"Guanine nucleotide-binding protein G(o) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Stimulated by RGS14. The G(o) protein function is not clear."},{"id":"ENSMUSP00000007275","abundance":147,"rank":697,"name":"Krt13","annotation":"Keratin, type I cytoskeletal 13."},{"id":"ENSMUSP00000017270","abundance":147,"rank":698,"name":"Krt42","annotation":"Keratin, type I cytoskeletal 42; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000065770","abundance":147,"rank":699,"name":"Ilf3","annotation":"Interleukin enhancer-binding factor 3; RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back- splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post- transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of tar [...] "},{"id":"ENSMUSP00000132222","abundance":147,"rank":700,"name":"Ddx39","annotation":"ATP-dependent RNA helicase DDX39A; Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity)."},{"id":"ENSMUSP00000099436","abundance":147,"rank":701,"name":"Psmb3","annotation":"Proteasome subunit beta type-3; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] "},{"id":"ENSMUSP00000021459","abundance":147,"rank":702,"name":"Rab15","annotation":"Ras-related protein Rab-15; May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal. EHBP1L1."},{"id":"ENSMUSP00000010520","abundance":147,"rank":703,"name":"Nedd8","annotation":"NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins."},{"id":"ENSMUSP00000102288","abundance":147,"rank":704,"name":"Prkar1a","annotation":"cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells."},{"id":"ENSMUSP00000007012","abundance":146,"rank":705,"name":"Sod2","annotation":"Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family."},{"id":"ENSMUSP00000023710","abundance":146,"rank":706,"name":"Krt71","annotation":"Keratin, type II cytoskeletal 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle."},{"id":"ENSMUSP00000022293","abundance":146,"rank":707,"name":"Vdac2","annotation":"Voltage-dependent anion-selective channel protein 2; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity)."},{"id":"ENSMUSP00000076933","abundance":145,"rank":708,"name":"Arpc5","annotation":"Actin-related protein 2/3 complex subunit 5; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA [...] "},{"id":"ENSMUSP00000072136","abundance":145,"rank":709,"name":"Flot2","annotation":"Flotillin-2; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function; Belongs to the band 7/mec-2 family. Flotillin subfamily."},{"id":"ENSMUSP00000133117","abundance":145,"rank":710,"name":"Fga","annotation":"Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it i [...] "},{"id":"ENSMUSP00000020775","abundance":145,"rank":711,"name":"Dynll2","annotation":"Dynein light chain 2, cytoplasmic; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity)."},{"id":"ENSMUSP00000073764","abundance":145,"rank":712,"name":"Aldh3a2","annotation":"Aldehyde dehydrogenase family 3 member A2; Catalyzes the oxidation of medium and long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1- phosphate (S1P) degradation product hexadecenal to hexadecenoic acid."},{"id":"ENSMUSP00000108804","abundance":145,"rank":713,"name":"Afm","annotation":"Afamin; Functions as carrier for hydrophobic molecules in body fluids. Essential for the solubility and activity of lipidated Wnt family members, including WNT1, WNT2B, WNT3, WNT3A, WNT5A, WNT7A, WNT7B, WNT8, WNT9A, WNT9B, WNT10A and WNT10B. Binds vitamin E. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the transport of vitamin E across the blood-brain barrier."},{"id":"ENSMUSP00000110627","abundance":145,"rank":714,"name":"Luc7l","annotation":"Putative RNA-binding protein Luc7-like 1; May bind to RNA via its Arg/Ser-rich domain; Belongs to the Luc7 family."},{"id":"ENSMUSP00000108859","abundance":144,"rank":715,"name":"Eif4e2","annotation":"Eukaryotic translation initiation factor 4E type 2; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation (By similarity). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap."},{"id":"ENSMUSP00000029837","abundance":144,"rank":716,"name":"Uox","annotation":"Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin."},{"id":"ENSMUSP00000023583","abundance":144,"rank":717,"name":"Ahsg","annotation":"Alpha-2-HS-glycoprotein; Probably involved in differentiation; Belongs to the fetuin family."},{"id":"ENSMUSP00000001452","abundance":144,"rank":718,"name":"Cct3","annotation":"T-complex protein 1 subunit gamma; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin."},{"id":"ENSMUSP00000050374","abundance":143,"rank":719,"name":"Sfn","annotation":"14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family."},{"id":"ENSMUSP00000023799","abundance":143,"rank":720,"name":"Krt79","annotation":"Keratin, type II cytoskeletal 79; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000112928","abundance":143,"rank":721,"name":"Dpysl3","annotation":"Dihydropyrimidinase-related protein 3; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family."},{"id":"ENSMUSP00000025377","abundance":142,"rank":722,"name":"Ppp2r2b","annotation":"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance."},{"id":"ENSMUSP00000001051","abundance":142,"rank":723,"name":"S100a6","annotation":"Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity); Belongs to the S-100 family."},{"id":"ENSMUSP00000109305","abundance":142,"rank":724,"name":"Anxa4","annotation":"Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis."},{"id":"ENSMUSP00000096753","abundance":142,"rank":725,"name":"Nnt","annotation":"NAD(P) transhydrogenase, mitochondrial; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity). May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland (By similarity). In the N-terminal section; belongs to the AlaDH/PNT family."},{"id":"ENSMUSP00000152868","abundance":142,"rank":726,"name":"Nnt-2","annotation":"Nicotinamide nucleotide transhydrogenase."},{"id":"ENSMUSP00000114963","abundance":142,"rank":727,"name":"Ndufb5","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000110158","abundance":142,"rank":728,"name":"Gls","annotation":"Glutaminase kidney isoform, mitochondrial 65 kDa chain; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate, the main excitatory neurotransmitter in the brain."},{"id":"ENSMUSP00000132614","abundance":142,"rank":729,"name":"Hp1bp3","annotation":"Heterochromatin protein 1-binding protein 3; Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity. May play a role in hypoxia-induced oncogenesis."},{"id":"ENSMUSP00000084043","abundance":142,"rank":730,"name":"Spp1","annotation":"Osteopontin; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction; Belongs to the osteopontin family."},{"id":"ENSMUSP00000099634","abundance":141,"rank":731,"name":"Acadvl","annotation":"Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons (By similarity); Belongs to the acyl-CoA dehydrogenase family."},{"id":"ENSMUSP00000129559","abundance":141,"rank":732,"name":"Rasl2-9","annotation":"GTP-binding nuclear protein Ran, testis-specific isoform; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity)."},{"id":"ENSMUSP00000144932","abundance":141,"rank":733,"name":"Ndufa4","annotation":"Cytochrome c oxidase subunit NDUFA4; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport  [...] "},{"id":"ENSMUSP00000101003","abundance":141,"rank":734,"name":"Ndufs7","annotation":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000029142","abundance":140,"rank":735,"name":"Eif6","annotation":"Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] "},{"id":"ENSMUSP00000023714","abundance":140,"rank":736,"name":"Krt90","annotation":"Keratin 90; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000145194","abundance":139,"rank":737,"name":"Eif4a3l2","annotation":"Eukaryotic translation initiation factor 4A3-like 2; Belongs to the DEAD box helicase family."},{"id":"ENSMUSP00000026289","abundance":139,"rank":738,"name":"Hsd17b10","annotation":"3-hydroxyacyl-CoA dehydrogenase type-2; Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha- hydroxysteroid dehydrogenase activity with androsterone (By similarity). Catalyzes the third step in the beta-oxidation of fatty acids (By similarity). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (By similarity). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (By similarity). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction  [...] "},{"id":"ENSMUSP00000022322","abundance":138,"rank":739,"name":"Glud1","annotation":"Glutamate dehydrogenase 1, mitochondrial; Mitochondrial glutamate dehydrogenase that converts L- glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle. May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family."},{"id":"ENSMUSP00000032946","abundance":138,"rank":740,"name":"Rab6a","annotation":"Ras-related protein Rab-6A; Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Involved in COPI-independent retrograde transport from the Golgi to the ER (By similarity); Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000021239","abundance":138,"rank":741,"name":"Lrrc59","annotation":"Leucine-rich repeat-containing protein 59, N-terminally processed; Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity)."},{"id":"ENSMUSP00000107498","abundance":138,"rank":742,"name":"Sufu","annotation":"Suppressor of fused homolog; Negative regulator in the hedgehog/smoothened signaling pathway. Down-regulates GLI1- mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome (By similarity). Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A)  [...] "},{"id":"ENSMUSP00000111032","abundance":138,"rank":743,"name":"Rbm10","annotation":"RNA-binding protein 10; Not known. Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (By similarity)."},{"id":"ENSMUSP00000023116","abundance":138,"rank":744,"name":"Aco2","annotation":"Aconitate hydratase, mitochondrial; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate; Belongs to the aconitase/IPM isomerase family."},{"id":"ENSMUSP00000090237","abundance":137,"rank":745,"name":"Src","annotation":"Neuronal proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redun [...] "},{"id":"ENSMUSP00000025402","abundance":137,"rank":746,"name":"Gnal","annotation":"Guanine nucleotide-binding protein G(olf) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(olf) alpha mediates signal transduction within the olfactory neuroepithelium and the basal ganglia. May be involved in some aspect of visual transduction, and in mediating the effect of one or more hormones/neurotransmitters (By similarity); Belongs to the G-alpha family. G(s) subfamily."},{"id":"ENSMUSP00000030340","abundance":137,"rank":747,"name":"Scp2","annotation":"Non-specific lipid-transfer protein; Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis."},{"id":"ENSMUSP00000155657","abundance":137,"rank":748,"name":"Rpl8","annotation":"60S ribosomal protein L8; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL2 family."},{"id":"ENSMUSP00000113322","abundance":137,"rank":749,"name":"Rab3d","annotation":"Ras-related protein Rab-3D; Protein transport. Probably involved in vesicular traffic (By similarity). May be involved in the insulin-induced exocytosis of glut4-containing vesicles in adipocytes."},{"id":"ENSMUSP00000005826","abundance":137,"rank":750,"name":"Cs","annotation":"Citrate synthase, mitochondrial; Belongs to the citrate synthase family."},{"id":"ENSMUSP00000134163","abundance":137,"rank":751,"name":"H2-Q10","annotation":"H-2 class I histocompatibility antigen, Q10 alpha chain; Involved in the presentation of foreign antigens to the immune system."},{"id":"ENSMUSP00000027144","abundance":137,"rank":752,"name":"Cps1","annotation":"Carbamoyl-phosphate synthase [ammonia], mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell."},{"id":"ENSMUSP00000043092","abundance":137,"rank":753,"name":"Blvrb","annotation":"Flavin reductase (NADPH); Broad specificity oxidoreductase that catalyzes the NADPH- dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin."},{"id":"ENSMUSP00000114764","abundance":136,"rank":754,"name":"Ube2v1","annotation":"Ubiquitin-conjugating enzyme E2 variant 1."},{"id":"ENSMUSP00000132102","abundance":136,"rank":755,"name":"Rps27","annotation":"Ribosomal protein S27."},{"id":"ENSMUSP00000060523","abundance":136,"rank":756,"name":"Rps27rt","annotation":"40S ribosomal protein S27; Component of the small ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 18S rRNAs (By similarity)."},{"id":"ENSMUSP00000028241","abundance":136,"rank":757,"name":"Stom","annotation":"Erythrocyte band 7 integral membrane protein; Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity. Belongs to the band 7/mec-2 family."},{"id":"ENSMUSP00000100045","abundance":136,"rank":758,"name":"Akr1b3","annotation":"Aldo-keto reductase family 1 member B1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis- retinal. Catalyzes t [...] "},{"id":"ENSMUSP00000129121","abundance":136,"rank":759,"name":"Acot7","annotation":"Cytosolic acyl coenzyme A thioester hydrolase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 7/ACOT7 preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18 (Probable). May play an important physiological function in brain."},{"id":"ENSMUSP00000058321","abundance":136,"rank":760,"name":"Cavin1","annotation":"Caveolae-associated protein 1; Plays an important role in caveolae formation and organization. Essential for the formation of caveolae in all tissues. Core component of the CAVIN complex which is essential for recruitment of the complex to the caveolae in presence of calveolin-1 (CAV1). Essential for normal oligomerization of CAV1. Promotes ribosomal transcriptional activity in response to metabolic challenges in the adipocytes and plays an important role in the formation of the ribosomal transcriptional loop. Dissociates transcription complexes paused by DNA- bound TTF1, thereby relea [...] "},{"id":"ENSMUSP00000099939","abundance":135,"rank":761,"name":"Ugp2","annotation":"UTP--glucose-1-phosphate uridylyltransferase; Plays a central role as a glucosyl donor in cellular metabolic pathways."},{"id":"ENSMUSP00000018561","abundance":135,"rank":762,"name":"Myo1b","annotation":"Unconventional myosin-Ib; Motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport."},{"id":"ENSMUSP00000031779","abundance":135,"rank":763,"name":"Calu","annotation":"Calumenin; Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma- carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity)."},{"id":"ENSMUSP00000091940","abundance":135,"rank":764,"name":"Shc1","annotation":"SHC-transforming protein 1; Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p47Shc and isoform p52Shc, once phosphorylated, couple activated receptor kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals.  [...] "},{"id":"ENSMUSP00000018156","abundance":135,"rank":765,"name":"Rac3","annotation":"Ras-related C3 botulinum toxin substrate 3; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner."},{"id":"ENSMUSP00000068890","abundance":134,"rank":766,"name":"Pfn2","annotation":"Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG."},{"id":"ENSMUSP00000051222","abundance":134,"rank":767,"name":"Atp5k","annotation":"ATP synthase subunit e, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] "},{"id":"ENSMUSP00000012348","abundance":134,"rank":768,"name":"Gstm2","annotation":"Glutathione S-transferase Mu 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family."},{"id":"ENSMUSP00000085299","abundance":134,"rank":769,"name":"Dlg3","annotation":"Disks large homolog 3; Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling."},{"id":"ENSMUSP00000051799","abundance":134,"rank":770,"name":"Ensa","annotation":"Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity)."},{"id":"ENSMUSP00000020238","abundance":133,"rank":771,"name":"Hsp90b1","annotation":"Endoplasmin; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD) (By similarity). Has ATPase activity ; Belongs to the heat shock protein 90 family."},{"id":"ENSMUSP00000005647","abundance":133,"rank":772,"name":"Ndufs3","annotation":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000101924","abundance":133,"rank":773,"name":"Ppih","annotation":"Peptidyl-prolyl cis-trans isomerase H; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone. Belongs to the cyclophilin-type PPIase family. PPIase H subfamily."},{"id":"ENSMUSP00000020504","abundance":133,"rank":774,"name":"Hint1","annotation":"Histidine triad nucleotide-binding protein 1; Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guano [...] "},{"id":"ENSMUSP00000046636","abundance":133,"rank":775,"name":"Gc","annotation":"Vitamin D-binding protein; Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation."},{"id":"ENSMUSP00000020263","abundance":133,"rank":776,"name":"Hnrnph3","annotation":"Heterogeneous nuclear ribonucleoprotein H3."},{"id":"ENSMUSP00000075945","abundance":133,"rank":777,"name":"Fcgbp","annotation":"Fc fragment of IgG-binding protein."},{"id":"ENSMUSP00000093702","abundance":133,"rank":778,"name":"Prss3","annotation":"Protease, serine 3; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000126702","abundance":132,"rank":779,"name":"Dpy30","annotation":"Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and histone H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. May also play [...] "},{"id":"ENSMUSP00000101972","abundance":132,"rank":780,"name":"Coro1a","annotation":"Coronin-1A; May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes."},{"id":"ENSMUSP00000064163","abundance":132,"rank":781,"name":"Flnc","annotation":"Filamin-C; Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers."},{"id":"ENSMUSP00000064691","abundance":132,"rank":782,"name":"Gfap","annotation":"Glial fibrillary acidic protein; GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells."},{"id":"ENSMUSP00000022616","abundance":131,"rank":783,"name":"Clu","annotation":"Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins (By similarity). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and  [...] "},{"id":"ENSMUSP00000110574","abundance":131,"rank":784,"name":"Celf2","annotation":"CUGBP Elav-like family member 2; RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle (By similarity). Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Acts as both an activator and re [...] "},{"id":"ENSMUSP00000058432","abundance":131,"rank":785,"name":"Rps21","annotation":"40S ribosomal protein S21; Belongs to the eukaryotic ribosomal protein eS21 family."},{"id":"ENSMUSP00000036384","abundance":130,"rank":786,"name":"Rac2","annotation":"Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase."},{"id":"ENSMUSP00000069350","abundance":130,"rank":787,"name":"Madd","annotation":"MAP kinase-activating death domain protein; Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP- bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis)."},{"id":"ENSMUSP00000113886","abundance":130,"rank":788,"name":"Rab4a","annotation":"Ras-related protein Rab-4A; Protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling."},{"id":"ENSMUSP00000066639","abundance":129,"rank":789,"name":"Pabpc2","annotation":"Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family."},{"id":"ENSMUSP00000086094","abundance":129,"rank":790,"name":"Smarcc1","annotation":"SWI/SNF complex subunit SMARCC1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF [...] "},{"id":"ENSMUSP00000099685","abundance":128,"rank":791,"name":"Sars","annotation":"Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16 [...] "},{"id":"ENSMUSP00000110882","abundance":128,"rank":792,"name":"Bdh1","annotation":"D-beta-hydroxybutyrate dehydrogenase, mitochondrial."},{"id":"ENSMUSP00000018727","abundance":128,"rank":793,"name":"G3bp1","annotation":"Ras GTPase-activating protein-binding protein 1; ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RN [...] "},{"id":"ENSMUSP00000086987","abundance":128,"rank":794,"name":"Snrpg","annotation":"Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing."},{"id":"ENSMUSP00000018698","abundance":128,"rank":795,"name":"Ybx2","annotation":"Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA- 3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplas [...] "},{"id":"ENSMUSP00000025918","abundance":128,"rank":796,"name":"Stip1","annotation":"Stress-induced-phosphoprotein 1; Acts as a co-chaperone for HSP90AA1. Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90."},{"id":"ENSMUSP00000117690","abundance":128,"rank":797,"name":"Tpd52l2","annotation":"Tumor protein D54."},{"id":"ENSMUSP00000034046","abundance":127,"rank":798,"name":"Acsl1","annotation":"Long-chain-fatty-acid--CoA ligase 1; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs); Belongs to the ATP-dependent AMP-binding enzyme family."},{"id":"ENSMUSP00000025217","abundance":127,"rank":799,"name":"Hspa9","annotation":"Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (By similarity). Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family."},{"id":"ENSMUSP00000112618","abundance":127,"rank":800,"name":"Crybb3","annotation":"Beta-crystallin B3, N-terminally processed; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000113157","abundance":126,"rank":801,"name":"Cbx5","annotation":"Chromobox protein homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity)."},{"id":"ENSMUSP00000033008","abundance":126,"rank":802,"name":"Psma1","annotation":"Proteasome subunit alpha type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] "},{"id":"ENSMUSP00000020123","abundance":126,"rank":803,"name":"Tmpo","annotation":"Lamina-associated polypeptide 2, isoforms alpha/zeta; May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1 (By similarity)."},{"id":"ENSMUSP00000032078","abundance":126,"rank":804,"name":"Cct7","annotation":"T-complex protein 1 subunit eta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin; Belongs to the TCP-1 chaperonin family."},{"id":"ENSMUSP00000115723","abundance":125,"rank":805,"name":"Pitpna","annotation":"Phosphatidylinositol transfer protein alpha isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes."},{"id":"ENSMUSP00000009774","abundance":125,"rank":806,"name":"Ppp2cb","annotation":"Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase."},{"id":"ENSMUSP00000088935","abundance":125,"rank":807,"name":"Sumo1","annotation":"Small ubiquitin-related modifier 1; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post- translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for insta [...] "},{"id":"ENSMUSP00000023514","abundance":125,"rank":808,"name":"Ndufb4","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000123866","abundance":125,"rank":809,"name":"Pcmt1","annotation":"Protein-L-isoaspartate(D-aspartate) O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl and D- aspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin carboxyl-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein."},{"id":"ENSMUSP00000088736","abundance":124,"rank":810,"name":"Eif2s3y","annotation":"Eukaryotic translation initiation factor 2 subunit 3, Y-linked; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary com [...] "},{"id":"ENSMUSP00000080994","abundance":124,"rank":811,"name":"mt-Co2","annotation":"Cytochrome c oxidase subunit 2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] "},{"id":"ENSMUSP00000066068","abundance":124,"rank":812,"name":"Actn4","annotation":"Alpha-actinin-4; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stim [...] "},{"id":"ENSMUSP00000018737","abundance":124,"rank":813,"name":"Sparc","annotation":"SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity; Belongs to the SPARC family."},{"id":"ENSMUSP00000025561","abundance":123,"rank":814,"name":"Anxa1","annotation":"Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing. Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contributes to the adapti [...] "},{"id":"ENSMUSP00000049625","abundance":123,"rank":815,"name":"Gtf2i","annotation":"General transcription factor II-I; Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box (By similarit [...] "},{"id":"ENSMUSP00000031492","abundance":123,"rank":816,"name":"Rab35","annotation":"Ras-related protein Rab-35; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required f [...] "},{"id":"ENSMUSP00000121203","abundance":123,"rank":817,"name":"Ctsd","annotation":"Cathepsin D; Acid protease active in intracellular protein breakdown. Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation; Belongs to the peptidase A1 family."},{"id":"ENSMUSP00000064282","abundance":122,"rank":818,"name":"Atpif1","annotation":"ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase (By similarity). Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorpo [...] "},{"id":"ENSMUSP00000147502","abundance":122,"rank":819,"name":"Ruvbl2","annotation":"RuvB-like 2; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (5' to 3') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] "},{"id":"ENSMUSP00000020608","abundance":122,"rank":820,"name":"Ppp2ca","annotation":"Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase- mediated cleavage in oocytes specifically during meiosis I. Activates RAF1 by dephosphorylating it at 'Ser-259' (By similarity)."},{"id":"ENSMUSP00000064538","abundance":122,"rank":821,"name":"Dnm3","annotation":"Dynamin-3; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis (By similarity)."},{"id":"ENSMUSP00000071231","abundance":121,"rank":822,"name":"Pygl","annotation":"Glycogen phosphorylase, liver form; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)."},{"id":"ENSMUSP00000074810","abundance":121,"rank":823,"name":"Orm2","annotation":"Alpha-1-acid glycoprotein 2; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction."},{"id":"ENSMUSP00000072773","abundance":121,"rank":824,"name":"Postn","annotation":"Periostin; Induces cell attachment and spreading and plays a role in cell adhesion. Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX."},{"id":"ENSMUSP00000047410","abundance":121,"rank":825,"name":"Tax1bp3","annotation":"Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway (By similarity)."},{"id":"ENSMUSP00000007814","abundance":121,"rank":826,"name":"Khsrp","annotation":"Far upstream element-binding protein 2; Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU- rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-contain [...] "},{"id":"ENSMUSP00000033098","abundance":121,"rank":827,"name":"Bcat2","annotation":"Branched-chain-amino-acid aminotransferase, mitochondrial; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids."},{"id":"ENSMUSP00000102261","abundance":121,"rank":828,"name":"Rab3b","annotation":"Ras-related protein Rab-3B; Protein transport. Probably involved in vesicular traffic (By similarity)."},{"id":"ENSMUSP00000059395","abundance":121,"rank":829,"name":"Eif2s3x","annotation":"Eukaryotic translation initiation factor 2 subunit 3, X-linked; As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary com [...] "},{"id":"ENSMUSP00000109388","abundance":120,"rank":830,"name":"Odf2","annotation":"Outer dense fiber protein 2; Seems to be a major component of sperm tail outer dense fibers (ODF). ODFs are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. May have a modulating influence on sperm motility. Functions as a general scaffold protein that is specifically localized at the distal/subdistal appendages of mother centrioles. Component of the centrosome matrix required for the localization of PLK1 and NIN to th [...] "},{"id":"ENSMUSP00000102536","abundance":120,"rank":831,"name":"Rhog","annotation":"Rho-related GTP-binding protein RhoG; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity)."},{"id":"ENSMUSP00000119443","abundance":120,"rank":832,"name":"Mpc1","annotation":"Mitochondrial pyruvate carrier 1; Mediates the uptake of pyruvate into mitochondria."},{"id":"ENSMUSP00000024988","abundance":120,"rank":833,"name":"C3","annotation":"Complement C3c alpha' chain fragment 1; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. [C3-beta-c]: Acts as a chemoattractant for neutrophils in chronic inflammation."},{"id":"ENSMUSP00000098076","abundance":119,"rank":834,"name":"Eif3b","annotation":"Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] "},{"id":"ENSMUSP00000118591","abundance":119,"rank":835,"name":"Cend1","annotation":"Cell cycle exit and neuronal differentiation protein 1; Involved in neuronal differentiation. Belongs to the CEND1 family."},{"id":"ENSMUSP00000028727","abundance":119,"rank":836,"name":"Snap25","annotation":"Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells (By similarity)."},{"id":"ENSMUSP00000023803","abundance":118,"rank":837,"name":"Krt18","annotation":"Keratin, type I cytoskeletal 18; When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection."},{"id":"ENSMUSP00000065352","abundance":118,"rank":838,"name":"Ndufa8","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000023994","abundance":118,"rank":839,"name":"Serping1","annotation":"Plasma protease C1 inhibitor; Activation of the C1 complex is under control of the C1- inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein."},{"id":"ENSMUSP00000033662","abundance":118,"rank":840,"name":"Pdha1","annotation":"Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle."},{"id":"ENSMUSP00000104091","abundance":118,"rank":841,"name":"Apoc1","annotation":"Truncated apolipoprotein C-I; Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta [...] "},{"id":"ENSMUSP00000033763","abundance":118,"rank":842,"name":"Naa10","annotation":"N-alpha-acetyltransferase 10; Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. Acetylates amino termini that are devoid of initiator methionine (By similarity). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development (By similarity). Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation. Represses MYLK kinase activity by acetylation, and thus represses tumor cell mi [...] "},{"id":"ENSMUSP00000048704","abundance":117,"rank":843,"name":"Serpinf2","annotation":"Alpha-2-antiplasmin; Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase- 3/TMPRSS7 and chymotrypsin (By similarity)."},{"id":"ENSMUSP00000084882","abundance":117,"rank":844,"name":"Gda","annotation":"Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family."},{"id":"ENSMUSP00000139129","abundance":117,"rank":845,"name":"Gm5269","annotation":"Predicted gene 5269."},{"id":"ENSMUSP00000129565","abundance":117,"rank":846,"name":"Gstp1","annotation":"Glutathione S-transferase P 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Can metabolize 1- chloro-2,4-dinitrobenzene. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity)."},{"id":"ENSMUSP00000034585","abundance":116,"rank":847,"name":"Apoa4","annotation":"Apolipoprotein A-IV; May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons; Belongs to the apolipoprotein A1/A4/E family."},{"id":"ENSMUSP00000146028","abundance":116,"rank":848,"name":"Plin1","annotation":"Perilipin-1; Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness (By similarity). Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels."},{"id":"ENSMUSP00000000137","abundance":116,"rank":849,"name":"Actr2","annotation":"Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] "},{"id":"ENSMUSP00000093698","abundance":116,"rank":850,"name":"Gm10334","annotation":"Predicted gene 10334; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000029955","abundance":116,"rank":851,"name":"1700009N14Rik","annotation":"GTP-binding nuclear protein Ran; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family."},{"id":"ENSMUSP00000090910","abundance":116,"rank":852,"name":"Ces3a","annotation":"Carboxylesterase 3A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000025684","abundance":115,"rank":853,"name":"Ehd1","annotation":"EH domain-containing protein 1; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (By similarity). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion. Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating  [...] "},{"id":"ENSMUSP00000045487","abundance":115,"rank":854,"name":"4930544G11Rik","annotation":"RIKEN cDNA 4930544G11 gene."},{"id":"ENSMUSP00000144809","abundance":114,"rank":855,"name":"Eif4a3l1","annotation":"Eukaryotic translation initiation factor 4A3-like 1; Belongs to the DEAD box helicase family."},{"id":"ENSMUSP00000014545","abundance":114,"rank":856,"name":"Ldhc","annotation":"L-lactate dehydrogenase C chain; Possible role in sperm motility; Belongs to the LDH/MDH superfamily. LDH family."},{"id":"ENSMUSP00000097738","abundance":114,"rank":857,"name":"Copz1","annotation":"Coatomer subunit zeta-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-disso [...] "},{"id":"ENSMUSP00000112320","abundance":114,"rank":858,"name":"Ndufb11","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000059749","abundance":114,"rank":859,"name":"Rbp1","annotation":"Retinol-binding protein 1; Cytoplasmic retinol-binding protein. Accepts retinol from the transport protein STRA6, and thereby contributes to retinol uptake, storage and retinoid homeostasis."},{"id":"ENSMUSP00000025904","abundance":113,"rank":860,"name":"Prdx5","annotation":"Peroxiredoxin-5, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events."},{"id":"ENSMUSP00000029422","abundance":113,"rank":861,"name":"Shox2","annotation":"Short stature homeobox protein 2; May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation. May also have a role in heart development."},{"id":"ENSMUSP00000109979","abundance":113,"rank":862,"name":"Add1","annotation":"Alpha-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin."},{"id":"ENSMUSP00000002551","abundance":113,"rank":863,"name":"Snrpd1","annotation":"Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA."},{"id":"ENSMUSP00000080242","abundance":112,"rank":864,"name":"Alyref2","annotation":"Aly/REF export factor 2; Export adapter involved in spliced and unspliced mRNA nuclear export. Binds mRNA which is transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway); enhances NXF1-NXT1 RNA-binding activity."},{"id":"ENSMUSP00000092746","abundance":112,"rank":865,"name":"Ndufb6","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000103000","abundance":112,"rank":866,"name":"Tnc","annotation":"Tenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity); Belongs to the tenascin family."},{"id":"ENSMUSP00000066035","abundance":112,"rank":867,"name":"Anxa7","annotation":"Annexin A7; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family."},{"id":"ENSMUSP00000116108","abundance":112,"rank":868,"name":"Tcp1","annotation":"T-complex protein 1 subunit alpha; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin."},{"id":"ENSMUSP00000019470","abundance":112,"rank":869,"name":"Psme3","annotation":"Proteasome activator complex subunit 3; Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regul [...] "},{"id":"ENSMUSP00000130668","abundance":111,"rank":870,"name":"Ncam1","annotation":"Neural cell adhesion molecule 1; This protein is a cell adhesion molecule involved in neuron- neuron adhesion, neurite fasciculation, outgrowth of neurites, etc."},{"id":"ENSMUSP00000102381","abundance":111,"rank":871,"name":"Capza1","annotation":"F-actin-capping protein subunit alpha-1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions."},{"id":"ENSMUSP00000109530","abundance":111,"rank":872,"name":"Apoo","annotation":"MICOS complex subunit Mic26; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (By similarity). Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal tri [...] "},{"id":"ENSMUSP00000026122","abundance":111,"rank":873,"name":"P4hb","annotation":"Protein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chape [...] "},{"id":"ENSMUSP00000106090","abundance":111,"rank":874,"name":"Cops2","annotation":"COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kina [...] "},{"id":"ENSMUSP00000069418","abundance":111,"rank":875,"name":"C4b","annotation":"Complement C4 alpha chain; Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens (By similarity)."},{"id":"ENSMUSP00000013737","abundance":111,"rank":876,"name":"Ndufs2","annotation":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000082822","abundance":110,"rank":877,"name":"Arpc1b","annotation":"Actin-related protein 2/3 complex subunit 1B; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DN [...] "},{"id":"ENSMUSP00000105383","abundance":110,"rank":878,"name":"Rad23a","annotation":"UV excision repair protein RAD23 homolog A; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'- linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (By similarity); Belongs to the RAD23 family."},{"id":"ENSMUSP00000138342","abundance":110,"rank":879,"name":"Rpl9-ps1","annotation":"Ribosomal protein L9, pseudogene 1."},{"id":"ENSMUSP00000026704","abundance":110,"rank":880,"name":"Cct8","annotation":"T-complex protein 1 subunit theta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin."},{"id":"ENSMUSP00000021170","abundance":110,"rank":881,"name":"Mxra7","annotation":"Matrix-remodeling-associated protein 7."},{"id":"ENSMUSP00000029180","abundance":110,"rank":882,"name":"Rprd1b","annotation":"Regulation of nuclear pre-mRNA domain-containing protein 1B; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly- A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter thr [...] "},{"id":"ENSMUSP00000043308","abundance":110,"rank":883,"name":"Glyat","annotation":"Glycine N-acyltransferase; Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid."},{"id":"ENSMUSP00000028511","abundance":109,"rank":884,"name":"Mtx2","annotation":"Metaxin-2; Involved in transport of proteins into the mitochondrion."},{"id":"ENSMUSP00000119102","abundance":109,"rank":885,"name":"Snx12","annotation":"Sorting nexin-12; May be involved in several stages of intracellular trafficking."},{"id":"ENSMUSP00000126345","abundance":109,"rank":886,"name":"Rnps1","annotation":"RNA-binding protein with serine-rich domain 1; Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the E [...] "},{"id":"ENSMUSP00000070709","abundance":109,"rank":887,"name":"Fabp3","annotation":"Fatty acid-binding protein, heart; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters."},{"id":"ENSMUSP00000133302","abundance":109,"rank":888,"name":"Apoe","annotation":"Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density  [...] "},{"id":"ENSMUSP00000103034","abundance":109,"rank":889,"name":"Krt15","annotation":"Keratin, type I cytoskeletal 15; In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. Belongs to the intermediate filament family."},{"id":"ENSMUSP00000021226","abundance":109,"rank":890,"name":"Luc7l3","annotation":"Luc7-like protein 3; Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing (By similarity); Belongs to the Luc7 family."},{"id":"ENSMUSP00000033157","abundance":109,"rank":891,"name":"Ndufab1","annotation":"Acyl carrier protein, mitochondrial; Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity)."},{"id":"ENSMUSP00000155398","abundance":109,"rank":892,"name":"Gm49425","annotation":"Predicted gene, 49425."},{"id":"ENSMUSP00000106612","abundance":108,"rank":893,"name":"Dmtn","annotation":"Dematin; Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator  [...] "},{"id":"ENSMUSP00000105620","abundance":108,"rank":894,"name":"Tcn2","annotation":"Transcobalamin-2; Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells."},{"id":"ENSMUSP00000037348","abundance":108,"rank":895,"name":"Acaa2","annotation":"3-ketoacyl-CoA thiolase, mitochondrial; In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta- oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies. Also displays hydrolase activit [...] "},{"id":"ENSMUSP00000107955","abundance":108,"rank":896,"name":"Crybb2","annotation":"Beta-crystallin B2; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000121127","abundance":108,"rank":897,"name":"Gnb4","annotation":"Guanine nucleotide-binding protein subunit beta-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000026328","abundance":108,"rank":898,"name":"Prdx4","annotation":"Peroxiredoxin-4; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF- kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation (By similarity)."},{"id":"ENSMUSP00000089728","abundance":107,"rank":899,"name":"Usp14","annotation":"Ubiquitin carboxyl-terminal hydrolase 14; Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibi [...] "},{"id":"ENSMUSP00000030903","abundance":107,"rank":900,"name":"Atad3a","annotation":"ATPase family AAA domain-containing protein 3; Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis (By similarity); Belongs to the AAA ATPase family."},{"id":"ENSMUSP00000057543","abundance":107,"rank":901,"name":"Gnai2","annotation":"Guanine nucleotide-binding protein G(i) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta- adrenergic stimuli. May play a role in cell division."},{"id":"ENSMUSP00000086795","abundance":107,"rank":902,"name":"Lgals1","annotation":"Galectin-1; Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis."},{"id":"ENSMUSP00000124119","abundance":107,"rank":903,"name":"Cadm1","annotation":"Cell adhesion molecule 1; Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attach [...] "},{"id":"ENSMUSP00000146501","abundance":107,"rank":904,"name":"Picalm","annotation":"Phosphatidylinositol-binding clathrin assembly protein; Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocyto [...] "},{"id":"ENSMUSP00000029002","abundance":107,"rank":905,"name":"Stmn2","annotation":"Stathmin-2; Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone; Belongs to the stathmin family."},{"id":"ENSMUSP00000032168","abundance":106,"rank":906,"name":"Sec61a1","annotation":"Protein transport protein Sec61 subunit alpha isoform 1; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post- translational transport of small presecretory proteins. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC [...] "},{"id":"ENSMUSP00000022629","abundance":106,"rank":907,"name":"Dpysl2","annotation":"Dihydropyrimidinase-related protein 2; Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis; Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family."},{"id":"ENSMUSP00000119552","abundance":106,"rank":908,"name":"Spg7","annotation":"Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function (By similarity); In the C-terminal section; belongs to the peptidase M41 family."},{"id":"ENSMUSP00000036949","abundance":106,"rank":909,"name":"S100a10","annotation":"Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase; Belongs to the S-100 family."},{"id":"ENSMUSP00000093762","abundance":106,"rank":910,"name":"Tagln3","annotation":"Transgelin-3; Belongs to the calponin family."},{"id":"ENSMUSP00000030785","abundance":106,"rank":911,"name":"Espn","annotation":"Espin; Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircas [...] "},{"id":"ENSMUSP00000101833","abundance":105,"rank":912,"name":"Tial1","annotation":"Nucleolysin TIAR; RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (By similarity)."},{"id":"ENSMUSP00000028430","abundance":105,"rank":913,"name":"Cyct","annotation":"Cytochrome c, testis-specific; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain."},{"id":"ENSMUSP00000047872","abundance":105,"rank":914,"name":"Smc4","annotation":"Structural maintenance of chromosomes protein 4; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity)."},{"id":"ENSMUSP00000006625","abundance":105,"rank":915,"name":"Rbm14","annotation":"RNA-binding protein 14; May function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1 (By similarity). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune  [...] "},{"id":"ENSMUSP00000029987","abundance":105,"rank":916,"name":"Aldob","annotation":"Fructose-bisphosphate aldolase B."},{"id":"ENSMUSP00000022286","abundance":105,"rank":917,"name":"Ndufs4","annotation":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000022803","abundance":105,"rank":918,"name":"Psmb5","annotation":"Proteasome subunit beta type-5; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] "},{"id":"ENSMUSP00000041814","abundance":104,"rank":919,"name":"Lonp1","annotation":"Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] "},{"id":"ENSMUSP00000105028","abundance":104,"rank":920,"name":"Tnpo1","annotation":"Transportin-1; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis  [...] "},{"id":"ENSMUSP00000007266","abundance":103,"rank":921,"name":"Lsm2","annotation":"U6 snRNA-associated Sm-like protein LSm2; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA."},{"id":"ENSMUSP00000021554","abundance":103,"rank":922,"name":"Actn1","annotation":"Alpha-actinin-1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)."},{"id":"ENSMUSP00000032487","abundance":103,"rank":923,"name":"Vamp1","annotation":"Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane; Belongs to the synaptobrevin family."},{"id":"ENSMUSP00000112779","abundance":103,"rank":924,"name":"Mrps17","annotation":"28S ribosomal protein S17, mitochondrial; Belongs to the universal ribosomal protein uS17 family."},{"id":"ENSMUSP00000031866","abundance":103,"rank":925,"name":"Mtpn","annotation":"Myotrophin; Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy (By similarity). Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin- capping protein complex formed by the CAPZA1 and CAPZB heterodimer."},{"id":"ENSMUSP00000028592","abundance":103,"rank":926,"name":"Eif3m","annotation":"Eukaryotic translation initiation factor 3 subunit M; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] "},{"id":"ENSMUSP00000007280","abundance":102,"rank":927,"name":"Krt16","annotation":"Keratin, type I cytoskeletal 16; Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance."},{"id":"ENSMUSP00000133026","abundance":102,"rank":928,"name":"Tma7","annotation":"Translation machinery-associated protein 7; Belongs to the TMA7 family."},{"id":"ENSMUSP00000092065","abundance":102,"rank":929,"name":"Cfhr2","annotation":"Putative complement factor H-related protein B."},{"id":"ENSMUSP00000080568","abundance":102,"rank":930,"name":"Syn1","annotation":"Synapsin-1; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. Regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxide functions at a presynaptic level."},{"id":"ENSMUSP00000101673","abundance":102,"rank":931,"name":"Zranb2","annotation":"Zinc finger Ran-binding domain-containing protein 2; Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection (By similarity)."},{"id":"ENSMUSP00000117247","abundance":102,"rank":932,"name":"Gm49369","annotation":"Predicted gene, 49369; Belongs to the peptidase A1 family."},{"id":"ENSMUSP00000158738","abundance":102,"rank":933,"name":"Cct6a","annotation":"T-complex protein 1 subunit zeta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. The TRiC complex plays a role in the folding of actin and tubulin."},{"id":"ENSMUSP00000004990","abundance":102,"rank":934,"name":"Mapk14","annotation":"Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] "},{"id":"ENSMUSP00000126622","abundance":101,"rank":935,"name":"Zyx","annotation":"Zyxin; Adhesion plaque protein. Binds alpha-actinin and the CRP protein. Important for targeting TES and ENA/VASP family members to focal adhesions and for the formation of actin-rich structures. May be a component of a signal transduction pathway that mediates adhesion- stimulated changes in gene expression (By similarity)."},{"id":"ENSMUSP00000141022","abundance":101,"rank":936,"name":"Glrx2","annotation":"Glutaredoxin-2, mitochondrial; Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylat [...] "},{"id":"ENSMUSP00000035155","abundance":101,"rank":937,"name":"Rab6b","annotation":"Ras-related protein Rab-6B; Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (By similarity); Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000036288","abundance":101,"rank":938,"name":"Cct2","annotation":"T-complex protein 1 subunit beta; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin."},{"id":"ENSMUSP00000070149","abundance":101,"rank":939,"name":"Chchd3","annotation":"MICOS complex subunit Mic19; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology."},{"id":"ENSMUSP00000004137","abundance":101,"rank":940,"name":"Gstm7","annotation":"Glutathione S-transferase Mu 7; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family."},{"id":"ENSMUSP00000100924","abundance":101,"rank":941,"name":"Dcn","annotation":"Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily."},{"id":"ENSMUSP00000043074","abundance":101,"rank":942,"name":"Sncb","annotation":"Beta-synuclein; May be involved in neuronal plasticity."},{"id":"ENSMUSP00000021142","abundance":101,"rank":943,"name":"Atp2a3","annotation":"Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily."},{"id":"ENSMUSP00000118962","abundance":100,"rank":944,"name":"Amy2a1","annotation":"Alpha-amylase."},{"id":"ENSMUSP00000069900","abundance":100,"rank":945,"name":"Krt7","annotation":"Keratin, type II cytoskeletal 7; Blocks interferon-dependent interphase and stimulates DNA synthesis in cells."},{"id":"ENSMUSP00000065393","abundance":99.9,"rank":946,"name":"Prss2","annotation":"Anionic trypsin-2."},{"id":"ENSMUSP00000107607","abundance":99.8,"rank":947,"name":"Cfh","annotation":"Complement factor H; Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradati [...] "},{"id":"ENSMUSP00000097623","abundance":99.6,"rank":948,"name":"Kng2","annotation":"HMW kininogen-II."},{"id":"ENSMUSP00000026743","abundance":99.6,"rank":949,"name":"Uqcrc1","annotation":"Cytochrome b-c1 complex subunit 1, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradie [...] "},{"id":"ENSMUSP00000107448","abundance":99.5,"rank":950,"name":"Gmfb","annotation":"Glia maturation factor beta; This protein causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells; Belongs to the actin-binding proteins ADF family. GMF subfamily."},{"id":"ENSMUSP00000004729","abundance":99.4,"rank":951,"name":"Etfb","annotation":"Electron transfer flavoprotein subunit beta; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (By similarity). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role (By similarity)."},{"id":"ENSMUSP00000110314","abundance":99.3,"rank":952,"name":"Atp6v1a","annotation":"V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. May play a role in neurite development and synaptic connectivity."},{"id":"ENSMUSP00000137440","abundance":98.9,"rank":953,"name":"Canx","annotation":"Calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at t [...] "},{"id":"ENSMUSP00000124562","abundance":98.7,"rank":954,"name":"Manf","annotation":"Mesencephalic astrocyte-derived neurotrophic factor; Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted b [...] "},{"id":"ENSMUSP00000059419","abundance":98.6,"rank":955,"name":"Sfxn3","annotation":"Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family."},{"id":"ENSMUSP00000128353","abundance":98.5,"rank":956,"name":"G3bp2","annotation":"Ras GTPase-activating protein-binding protein 2; Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling."},{"id":"ENSMUSP00000109164","abundance":98.3,"rank":957,"name":"Fip1l1","annotation":"Pre-mRNA 3'-end-processing factor FIP1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity)."},{"id":"ENSMUSP00000109552","abundance":98.2,"rank":958,"name":"Dctn1","annotation":"Dynactin subunit 1; Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. C [...] "},{"id":"ENSMUSP00000027409","abundance":98.1,"rank":959,"name":"Des","annotation":"Desmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity (By similarity). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. May act as a sarcomeric m [...] "},{"id":"ENSMUSP00000109257","abundance":98.1,"rank":960,"name":"Pin4","annotation":"Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity)."},{"id":"ENSMUSP00000007708","abundance":98.1,"rank":961,"name":"Ppp2r1a","annotation":"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (By similarity). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (By similarity)."},{"id":"ENSMUSP00000005173","abundance":98,"rank":962,"name":"Sgsh","annotation":"N-sulfoglucosamine sulfohydrolase (sulfamidase)."},{"id":"ENSMUSP00000047661","abundance":97.9,"rank":963,"name":"Cox6a1","annotation":"Cytochrome c oxidase subunit 6A1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] "},{"id":"ENSMUSP00000023797","abundance":97.8,"rank":964,"name":"Krt4","annotation":"Keratin, type II cytoskeletal 4."},{"id":"ENSMUSP00000099907","abundance":97.7,"rank":965,"name":"Rtn4","annotation":"Reticulon-4; Required to induce the formation and stabilization of endoplasmic reticulum (ER) tubules. They regulate membrane morphogenesis in the ER by promoting tubular ER production. They influence nuclear envelope expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins. However each isoform have specific functions mainly depending on their tissue expression specificities. [Isoform B]: Mainly function in endothelial cells and vascular smooth muscle cells, is also involved in immune system regulation (Probable). Modulator of vascular remod [...] "},{"id":"ENSMUSP00000063548","abundance":97.7,"rank":966,"name":"Abat","annotation":"4-aminobutyrate aminotransferase, mitochondrial; Catalyzes the conversion of gamma-aminobutyrate and L-beta- aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine (By similarity)."},{"id":"ENSMUSP00000005651","abundance":97.6,"rank":967,"name":"Por","annotation":"NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family."},{"id":"ENSMUSP00000030623","abundance":97.6,"rank":968,"name":"Sfpq","annotation":"Splicing factor, proline- and glutamine-rich; DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphory [...] "},{"id":"ENSMUSP00000043821","abundance":97.4,"rank":969,"name":"Aldh4a1","annotation":"Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma- semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity)."},{"id":"ENSMUSP00000019192","abundance":97.3,"rank":970,"name":"Cryaa","annotation":"Alpha-crystallin A chain; Contributes to the transparency and refractive index of the lens (By similarity). Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions (By similarity). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity)."},{"id":"ENSMUSP00000081000","abundance":97.3,"rank":971,"name":"mt-Nd4","annotation":"NADH-ubiquinone oxidoreductase chain 4; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000083211","abundance":97.2,"rank":972,"name":"Nipsnap2","annotation":"Protein NipSnap homolog 2; May act as a positive regulator of L-type calcium channels."},{"id":"ENSMUSP00000089958","abundance":97.1,"rank":973,"name":"Dazap1","annotation":"DAZ-associated protein 1; RNA-binding protein, which may be required during spermatogenesis."},{"id":"ENSMUSP00000071054","abundance":97,"rank":974,"name":"Psmc3","annotation":"26S proteasome regulatory subunit 6A; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated wit [...] "},{"id":"ENSMUSP00000158541","abundance":96.9,"rank":975,"name":"Ndufs8","annotation":"NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000022327","abundance":96.7,"rank":976,"name":"Ldb3","annotation":"LIM domain-binding protein 3; May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton."},{"id":"ENSMUSP00000026818","abundance":96.3,"rank":977,"name":"Sec11a","annotation":"Signal peptidase complex catalytic subunit SEC11A; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum."},{"id":"ENSMUSP00000118221","abundance":96.1,"rank":978,"name":"Sri","annotation":"Sorcin; Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels."},{"id":"ENSMUSP00000144413","abundance":96.1,"rank":979,"name":"Hsph1","annotation":"Heat shock protein 105 kDa; Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities."},{"id":"ENSMUSP00000147013","abundance":96.1,"rank":980,"name":"U2af2","annotation":"Splicing factor U2AF 65 kDa subunit; Plays a role in pre-mRNA splicing and 3'-end processing. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals."},{"id":"ENSMUSP00000065113","abundance":95.7,"rank":981,"name":"Suclg1","annotation":"Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits."},{"id":"ENSMUSP00000128645","abundance":95.6,"rank":982,"name":"Rab12","annotation":"Ras-related protein Rab-12; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in au [...] "},{"id":"ENSMUSP00000007257","abundance":95.6,"rank":983,"name":"Clic1","annotation":"Chloride intracellular channel protein 1; Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions (By similarity)."},{"id":"ENSMUSP00000089800","abundance":95.5,"rank":984,"name":"Lyz1","annotation":"Lysozyme C-1; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Lyz1 is active against a range of Gram-positive and Gram-negative bacteria. Less effective than Lyz2 in killing Gram-negative bacteria. Lyz1 and Lyz2 are equally effective in killing Gram-positive bacteria; Belongs to the glycosyl hydrolase 22 family."},{"id":"ENSMUSP00000092225","abundance":95.5,"rank":985,"name":"Csn1s1","annotation":"Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate."},{"id":"ENSMUSP00000067541","abundance":95.3,"rank":986,"name":"C8a","annotation":"Complement component C8 alpha chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself (By similarity)."},{"id":"ENSMUSP00000098605","abundance":95.2,"rank":987,"name":"Atp2b2","annotation":"Plasma membrane calcium-transporting ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Plays a role in maintaining balance and hearing; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily."},{"id":"ENSMUSP00000029082","abundance":95.2,"rank":988,"name":"Psma7","annotation":"Proteasome subunit alpha type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] "},{"id":"ENSMUSP00000001592","abundance":95.1,"rank":989,"name":"Jup","annotation":"Junction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] "},{"id":"ENSMUSP00000140864","abundance":94.9,"rank":990,"name":"Dnpep","annotation":"Aspartyl aminopeptidase; Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity)."},{"id":"ENSMUSP00000103112","abundance":94.9,"rank":991,"name":"Mup3","annotation":"Major urinary protein 3; Binds pheromones that are released from drying urine of males. These pheromones affect the sexual behavior of females; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000024897","abundance":94.7,"rank":992,"name":"Vapa","annotation":"Vesicle-associated membrane protein-associated protein A; Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking; Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family."},{"id":"ENSMUSP00000031411","abundance":94.4,"rank":993,"name":"Aldh2","annotation":"Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid."},{"id":"ENSMUSP00000099399","abundance":94.4,"rank":994,"name":"Atp6v0a1","annotation":"V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity)."},{"id":"ENSMUSP00000095316","abundance":94.4,"rank":995,"name":"Idh1","annotation":"Isocitrate dehydrogenase [NADP] cytoplasmic; Belongs to the isocitrate and isopropylmalate dehydrogenases family."},{"id":"ENSMUSP00000063804","abundance":94.3,"rank":996,"name":"Rab39","annotation":"Ras-related protein Rab-39A; Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in vesicular trafficking. Plays a role in the fusion of phagosomes with lysosomes. Negatively regulates LPS-induced autophagosome formation in macrophages possibly by implicating PI3K (By similarity). May be involved in multiple neurite formation ; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000034881","abundance":94,"rank":997,"name":"Cox7a2","annotation":"Cytochrome c oxidase subunit 7A2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] "},{"id":"ENSMUSP00000021062","abundance":93.9,"rank":998,"name":"Ddx5","annotation":"Probable ATP-dependent RNA helicase DDX5; Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre- mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 t [...] "},{"id":"ENSMUSP00000090727","abundance":93.8,"rank":999,"name":"Rab4b","annotation":"Ras-related protein Rab-4B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000124291","abundance":93.7,"rank":1000,"name":"Naa50","annotation":"N-alpha-acetyltransferase 50; N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine. Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position. Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins. Autoacetylates in vivo. The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo.  [...] "},{"id":"ENSMUSP00000099490","abundance":93.7,"rank":1001,"name":"Acaca","annotation":"Acetyl-CoA carboxylase 1; Cytosolic enzyme that catalyzes the carboxylation of acetyl- CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA."},{"id":"ENSMUSP00000000001","abundance":93.5,"rank":1002,"name":"Gnai3","annotation":"Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] "},{"id":"ENSMUSP00000105796","abundance":93.5,"rank":1003,"name":"Ndufa13","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in [...] "},{"id":"ENSMUSP00000025951","abundance":93.4,"rank":1004,"name":"Rbp4","annotation":"Retinol-binding protein 4; Retinol-binding protein that mediates retinol transport in blood plasma. Delivers retinol from the liver stores to the peripheral tissues. Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane."},{"id":"ENSMUSP00000102598","abundance":93.3,"rank":1005,"name":"Folr1","annotation":"Folate receptor alpha; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption."},{"id":"ENSMUSP00000043926","abundance":93.3,"rank":1006,"name":"Pnp","annotation":"Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate."},{"id":"ENSMUSP00000074259","abundance":93.2,"rank":1007,"name":"Gnai1","annotation":"Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] "},{"id":"ENSMUSP00000034866","abundance":93.2,"rank":1008,"name":"Etfa","annotation":"Electron transfer flavoprotein subunit alpha, mitochondrial; Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF- ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism."},{"id":"ENSMUSP00000032974","abundance":93.2,"rank":1009,"name":"Atp2a1","annotation":"Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction."},{"id":"ENSMUSP00000033545","abundance":92.8,"rank":1010,"name":"Rab39b","annotation":"Ras-related protein Rab-39B; Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). May be involved in vesicular trafficking. Plays a role in synapse formation. May regulate the homeostasis of SNCA/alpha-synucl [...] "},{"id":"ENSMUSP00000028470","abundance":92.8,"rank":1011,"name":"Timm10","annotation":"Mitochondrial import inner membrane translocase subunit Tim10; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family."},{"id":"ENSMUSP00000004136","abundance":92.8,"rank":1012,"name":"Gstm3","annotation":"Glutathione S-transferase Mu 3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family."},{"id":"ENSMUSP00000085981","abundance":92.7,"rank":1013,"name":"Romo1","annotation":"Reactive oxygen species modulator 1; Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage (By similarity); Belongs to the MGR2 family."},{"id":"ENSMUSP00000032216","abundance":92.5,"rank":1014,"name":"Ptms","annotation":"Parathymosin; Parathymosin may mediate immune function by blocking the effect of prothymosin alpha which confers resistance to certain opportunistic infections."},{"id":"ENSMUSP00000084387","abundance":92.5,"rank":1015,"name":"Eif1ax","annotation":"Eukaryotic translation initiation factor 1A, X-chromosomal; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity)."},{"id":"ENSMUSP00000001547","abundance":92.4,"rank":1016,"name":"Col1a1","annotation":"Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family."},{"id":"ENSMUSP00000028335","abundance":92.3,"rank":1017,"name":"Grin1","annotation":"Glutamate receptor ionotropic, NMDA 1; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition."},{"id":"ENSMUSP00000114094","abundance":92.3,"rank":1018,"name":"Rab27b","annotation":"Ras-related protein Rab-27B; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (By similarity). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (By similarity). May be involved in targeting uroplakins to urothelial apical membranes (By similarity)."},{"id":"ENSMUSP00000026436","abundance":92.2,"rank":1019,"name":"Baiap2","annotation":"Brain-specific angiogenesis inhibitor 1-associated protein 2; Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling whe [...] "},{"id":"ENSMUSP00000020161","abundance":92.1,"rank":1020,"name":"Arg1","annotation":"Arginase-1; Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys."},{"id":"ENSMUSP00000025554","abundance":92,"rank":1021,"name":"Scgb1a1","annotation":"Uteroglobin; Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2; Belongs to the secretoglobin family."},{"id":"ENSMUSP00000036181","abundance":91.9,"rank":1022,"name":"Myo6","annotation":"Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway (By similarity).  [...] "},{"id":"ENSMUSP00000100868","abundance":91.7,"rank":1023,"name":"Smarcc2","annotation":"SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] "},{"id":"ENSMUSP00000098096","abundance":91.7,"rank":1024,"name":"Puf60","annotation":"Poly(U)-binding-splicing factor PUF60; DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice si [...] "},{"id":"ENSMUSP00000046837","abundance":91.5,"rank":1025,"name":"Ptpa","annotation":"Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine- protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+). Reversibly stimulates the variable phosphotyr [...] "},{"id":"ENSMUSP00000079100","abundance":91.4,"rank":1026,"name":"Slc1a2","annotation":"Excitatory amino acid transporter 2; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, an [...] "},{"id":"ENSMUSP00000053371","abundance":91.3,"rank":1027,"name":"Cltb","annotation":"Clathrin light chain B; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family."},{"id":"ENSMUSP00000072942","abundance":90.6,"rank":1028,"name":"H2-Q1","annotation":"Histocompatibility 2, Q region locus 1; Belongs to the MHC class I family."},{"id":"ENSMUSP00000091435","abundance":90.5,"rank":1029,"name":"Sept9","annotation":"Septin-9; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family."},{"id":"ENSMUSP00000055743","abundance":90.5,"rank":1030,"name":"Tst","annotation":"Thiosulfate sulfurtransferase; Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron- sulfur complexes and cyanide detoxification."},{"id":"ENSMUSP00000101004","abundance":90.4,"rank":1031,"name":"Cirbp","annotation":"Cold-inducible RNA-binding protein; Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold- induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN."},{"id":"ENSMUSP00000041149","abundance":90,"rank":1032,"name":"Mif","annotation":"Macrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] "},{"id":"ENSMUSP00000041453","abundance":89.7,"rank":1033,"name":"Clic4","annotation":"Chloride intracellular channel protein 4; Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3 (By similarity). May play a role in angiogenesis."},{"id":"ENSMUSP00000039472","abundance":89.6,"rank":1034,"name":"Fgb","annotation":"Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it  [...] "},{"id":"ENSMUSP00000086542","abundance":89.4,"rank":1035,"name":"Nsfl1c","annotation":"NSFL1 cofactor p47; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis."},{"id":"ENSMUSP00000023712","abundance":89.4,"rank":1036,"name":"Krt2","annotation":"Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification (By similarity). Associated with keratinocyte activation, proliferation and keratinization (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin."},{"id":"ENSMUSP00000008537","abundance":89.1,"rank":1037,"name":"Carhsp1","annotation":"Calcium-regulated heat stable protein 1; Binds mRNA and regulates the stability of target mRNA."},{"id":"ENSMUSP00000132945","abundance":89,"rank":1038,"name":"Rab3c","annotation":"Ras-related protein Rab-3C; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000029489","abundance":88.8,"rank":1039,"name":"Gstm4","annotation":"Glutathione S-transferase, mu 4."},{"id":"ENSMUSP00000112262","abundance":88.8,"rank":1040,"name":"Klc2","annotation":"Kinesin light chain 2; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity."},{"id":"ENSMUSP00000020285","abundance":88.7,"rank":1041,"name":"Sar1a","annotation":"GTP-binding protein SAR1a; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity); Belongs to the small GTPase superfamily. SAR1 family."},{"id":"ENSMUSP00000049303","abundance":88.5,"rank":1042,"name":"Prph","annotation":"Peripherin; Class-III neuronal intermediate filament protein; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000029476","abundance":88.5,"rank":1043,"name":"Sec22b","annotation":"Vesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER; Belongs to the synaptobrevin family."},{"id":"ENSMUSP00000038931","abundance":88.5,"rank":1044,"name":"Gstp2","annotation":"Glutathione S-transferase P 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene; Belongs to the GST superfamily. Pi family."},{"id":"ENSMUSP00000104737","abundance":88.4,"rank":1045,"name":"Nudt7","annotation":"Peroxisomal coenzyme A diphosphatase NUDT7; Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'- ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA a [...] "},{"id":"ENSMUSP00000080538","abundance":88.4,"rank":1046,"name":"Myh6","annotation":"Myosin-6; Muscle contraction."},{"id":"ENSMUSP00000099364","abundance":88.3,"rank":1047,"name":"Nsf","annotation":"Vesicle-fusing ATPase; Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack GRIA2 leads to influence GRIA2 membrane cycling (By similarity)."},{"id":"ENSMUSP00000030345","abundance":88.3,"rank":1048,"name":"Cpt2","annotation":"Carnitine O-palmitoyltransferase 2, mitochondrial; Belongs to the carnitine/choline acetyltransferase family."},{"id":"ENSMUSP00000098053","abundance":88.2,"rank":1049,"name":"Eif3d","annotation":"Eukaryotic translation initiation factor 3 subunit D; mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required  [...] "},{"id":"ENSMUSP00000050792","abundance":88.2,"rank":1050,"name":"Pabpc6","annotation":"Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family."},{"id":"ENSMUSP00000064498","abundance":88.1,"rank":1051,"name":"Try5","annotation":"Trypsinogen 9; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000106509","abundance":87.7,"rank":1052,"name":"Acp1","annotation":"Low molecular weight phosphotyrosine protein phosphatase; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates."},{"id":"ENSMUSP00000139264","abundance":87.6,"rank":1053,"name":"Gm17087","annotation":"Predicted gene 17087."},{"id":"ENSMUSP00000158365","abundance":87.5,"rank":1054,"name":"Pglyrp2","annotation":"N-acetylmuramoyl-L-alanine amidase; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family."},{"id":"ENSMUSP00000040781","abundance":87.2,"rank":1055,"name":"AA467197","annotation":"Normal mucosa of esophagus-specific gene 1 protein."},{"id":"ENSMUSP00000035743","abundance":87.2,"rank":1056,"name":"Pygb","annotation":"Glycogen phosphorylase, brain form; Glycogen phosphorylase that regulates glycogen mobilization. Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties."},{"id":"ENSMUSP00000032899","abundance":87.2,"rank":1057,"name":"1110004F10Rik","annotation":"Small acidic protein; Belongs to the SMAP family."},{"id":"ENSMUSP00000097547","abundance":87,"rank":1058,"name":"Fyn","annotation":"Tyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through  [...] "},{"id":"ENSMUSP00000005164","abundance":86.9,"rank":1059,"name":"Prkacb","annotation":"cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...] "},{"id":"ENSMUSP00000031038","abundance":86.9,"rank":1060,"name":"Ociad1","annotation":"OCIA domain-containing protein 1; Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes."},{"id":"ENSMUSP00000025649","abundance":86.6,"rank":1061,"name":"Ddb1","annotation":"DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6- 4 photoproducts (6-4 PP), apurinic sites and short mismatches (By similarity). Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which m [...] "},{"id":"ENSMUSP00000005017","abundance":86.5,"rank":1062,"name":"Hdgf","annotation":"Hepatoma-derived growth factor; Acts as a transcriptional repressor (By similarity). Has mitogenic activity for fibroblasts (By similarity). Heparin-binding protein (By similarity)."},{"id":"ENSMUSP00000099754","abundance":86.5,"rank":1063,"name":"Pemt","annotation":"Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family."},{"id":"ENSMUSP00000028683","abundance":86.4,"rank":1064,"name":"Pdia3","annotation":"Protein disulfide-isomerase A3."},{"id":"ENSMUSP00000118491","abundance":86.4,"rank":1065,"name":"Abi1","annotation":"Abl interactor 1; May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF- induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine n [...] "},{"id":"ENSMUSP00000106963","abundance":86.4,"rank":1066,"name":"Arhgap1","annotation":"Rho GTPase-activating protein 1; GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate (By similarity)."},{"id":"ENSMUSP00000091317","abundance":86.3,"rank":1067,"name":"Pls1","annotation":"Plastin-1; Actin-bundling protein in the absence of calcium."},{"id":"ENSMUSP00000029078","abundance":86.2,"rank":1068,"name":"Car2","annotation":"Carbonic anhydrase 2; Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton- coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6; Belongs to the alpha-carbonic anhydrase family."},{"id":"ENSMUSP00000085581","abundance":86.1,"rank":1069,"name":"Ube2c","annotation":"Ubiquitin-conjugating enzyme E2 C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit; Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000094151","abundance":86.1,"rank":1070,"name":"A1bg","annotation":"Alpha-1B-glycoprotein."},{"id":"ENSMUSP00000046772","abundance":86,"rank":1071,"name":"Hsd17b13","annotation":"17-beta-hydroxysteroid dehydrogenase 13."},{"id":"ENSMUSP00000087608","abundance":86,"rank":1072,"name":"Btd","annotation":"Biotinidase; Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation."},{"id":"ENSMUSP00000093425","abundance":85.8,"rank":1073,"name":"Tia1","annotation":"Nucleolysin TIA-1; Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis (By similarity)."},{"id":"ENSMUSP00000021639","abundance":85.8,"rank":1074,"name":"Tubal3","annotation":"Tubulin alpha chain-like 3; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)."},{"id":"ENSMUSP00000031913","abundance":85.7,"rank":1075,"name":"Try4","annotation":"Pancreatic trypsin; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000022122","abundance":85.7,"rank":1076,"name":"Ckmt2","annotation":"Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity)."},{"id":"ENSMUSP00000044033","abundance":85.7,"rank":1077,"name":"Serpina6","annotation":"Corticosteroid-binding globulin; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species; Belongs to the serpin family."},{"id":"ENSMUSP00000039692","abundance":85.7,"rank":1078,"name":"Ndufa7","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000024486","abundance":85.7,"rank":1079,"name":"Mrps23","annotation":"28S ribosomal protein S23, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS23 family."},{"id":"ENSMUSP00000150224","abundance":85.7,"rank":1080,"name":"Gm3776","annotation":"Glutathione S-transferase."},{"id":"ENSMUSP00000044502","abundance":85.6,"rank":1081,"name":"Efhd2","annotation":"EF-hand domain-containing protein D2; May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance."},{"id":"ENSMUSP00000032879","abundance":85.6,"rank":1082,"name":"Rab30","annotation":"Ras-related protein Rab-30; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Required for maintaining the structural integrity of the Golgi apparatus, possibly by mediating interactions with cytoplasmic scaffolding proteins (By similarity)."},{"id":"ENSMUSP00000006697","abundance":85.2,"rank":1083,"name":"Itih3","annotation":"Inter-alpha-trypsin inhibitor heavy chain H3; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes."},{"id":"ENSMUSP00000049739","abundance":85.2,"rank":1084,"name":"Rab9b","annotation":"Ras-related protein Rab-9B; Involved in the transport of proteins between the endosomes and the trans Golgi network; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000118478","abundance":85.1,"rank":1085,"name":"Ufm1","annotation":"Ubiquitin-fold modifier 1; Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine- linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (By similarity). Other substrates may include DDRGK1 with wh [...] "},{"id":"ENSMUSP00000021049","abundance":84.9,"rank":1086,"name":"Psmc5","annotation":"26S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] "},{"id":"ENSMUSP00000077716","abundance":84.8,"rank":1087,"name":"Rab43","annotation":"Ras-related protein Rab-43; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga [...] "},{"id":"ENSMUSP00000158495","abundance":84.6,"rank":1088,"name":"Lman1","annotation":"Protein ERGIC-53; Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins (By similarity)."},{"id":"ENSMUSP00000021076","abundance":84.5,"rank":1089,"name":"Rab37","annotation":"Ras-related protein Rab-37."},{"id":"ENSMUSP00000085365","abundance":84.4,"rank":1090,"name":"Krt86","annotation":"Keratin, type II cuticular Hb6; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000134570","abundance":84.3,"rank":1091,"name":"H2-D1","annotation":"H-2 class I histocompatibility antigen, D-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family."},{"id":"ENSMUSP00000130077","abundance":84.2,"rank":1092,"name":"Comt","annotation":"Catechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family."},{"id":"ENSMUSP00000080613","abundance":84.1,"rank":1093,"name":"Krt87","annotation":"Keratin, type II cuticular 87; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000044420","abundance":83.8,"rank":1094,"name":"Cdv3","annotation":"Protein CDV3; Belongs to the CDV3 family."},{"id":"ENSMUSP00000029041","abundance":83.8,"rank":1095,"name":"Fabp4","annotation":"Fatty acid-binding protein, adipocyte; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family."},{"id":"ENSMUSP00000065275","abundance":83.8,"rank":1096,"name":"Cast","annotation":"Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family."},{"id":"ENSMUSP00000075987","abundance":83.7,"rank":1097,"name":"Slc25a3","annotation":"Phosphate carrier protein, mitochondrial; Transport of phosphate groups from the cytosol to mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) (By similarity)."},{"id":"ENSMUSP00000136313","abundance":83.7,"rank":1098,"name":"Ndufa12","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000034204","abundance":83.6,"rank":1099,"name":"Nudt21","annotation":"Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The  [...] "},{"id":"ENSMUSP00000018449","abundance":83.6,"rank":1100,"name":"Prpf8","annotation":"Pre-mRNA-processing-splicing factor 8; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both t [...] "},{"id":"ENSMUSP00000033176","abundance":83.5,"rank":1101,"name":"Uqcrc2","annotation":"Cytochrome b-c1 complex subunit 2, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradie [...] "},{"id":"ENSMUSP00000077223","abundance":83.5,"rank":1102,"name":"Eif1a","annotation":"Eukaryotic translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000073061","abundance":83.5,"rank":1103,"name":"Pgrmc1","annotation":"Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs)."},{"id":"ENSMUSP00000015435","abundance":83.5,"rank":1104,"name":"Gdi1","annotation":"Rab GDP dissociation inhibitor alpha; Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes."},{"id":"ENSMUSP00000071589","abundance":83.4,"rank":1105,"name":"Psmd4","annotation":"26S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- [...] "},{"id":"ENSMUSP00000125003","abundance":83.3,"rank":1106,"name":"Srrm1","annotation":"Serine/arginine repetitive matrix protein 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with lo [...] "},{"id":"ENSMUSP00000036993","abundance":83.2,"rank":1107,"name":"Opa1","annotation":"Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Coexpression of isoform 1 with shorter alternative products is required for optimal activity in promoting mitochondrial fusion (By similarity). Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity).  [...] "},{"id":"ENSMUSP00000028607","abundance":83.2,"rank":1108,"name":"Caprin1","annotation":"Caprin-1; May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity). Belongs to the caprin family."},{"id":"ENSMUSP00000050156","abundance":83.2,"rank":1109,"name":"Timm8a1","annotation":"Mitochondrial import inner membrane translocase subunit Tim8 A; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8- TIMM13 complex mediates the import of proteins [...] "},{"id":"ENSMUSP00000102685","abundance":83,"rank":1110,"name":"Pdzk1","annotation":"Na(+)/H(+) exchange regulatory cofactor NHE-RF3; A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resista [...] "},{"id":"ENSMUSP00000111318","abundance":83,"rank":1111,"name":"Pqbp1","annotation":"Polyglutamine-binding protein 1; Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (By similarity). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species. May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner (By similarity). Can activate transcription directly or via association with the transcription machinery (By [...] "},{"id":"ENSMUSP00000019226","abundance":83,"rank":1112,"name":"Slc25a22","annotation":"Mitochondrial glutamate carrier 1; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000005606","abundance":82.9,"rank":1113,"name":"Prkaca","annotation":"cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...] "},{"id":"ENSMUSP00000034902","abundance":82.8,"rank":1114,"name":"Gsta2","annotation":"Glutathione S-transferase A2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles."},{"id":"ENSMUSP00000103438","abundance":82.6,"rank":1115,"name":"Tomm5","annotation":"Mitochondrial import receptor subunit TOM5 homolog."},{"id":"ENSMUSP00000039110","abundance":82.6,"rank":1116,"name":"Serbp1","annotation":"Plasminogen activator inhibitor 1 RNA-binding protein; May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation."},{"id":"ENSMUSP00000041104","abundance":82.5,"rank":1117,"name":"Aifm1","annotation":"Apoptosis-inducing factor 1, mitochondrial; Functions both as NADH oxidoreductase and as regulator of apoptosis (By similarity). In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Binds to DNA in a sequence- independent manner. Interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthe [...] "},{"id":"ENSMUSP00000107214","abundance":82.4,"rank":1118,"name":"Diablo","annotation":"Diablo homolog, mitochondrial; Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity)."},{"id":"ENSMUSP00000030212","abundance":82.4,"rank":1119,"name":"Sh3gl2","annotation":"Endophilin-A1; Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes."},{"id":"ENSMUSP00000146030","abundance":82.3,"rank":1120,"name":"Txnrd2","annotation":"Thioredoxin reductase 2, mitochondrial; Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling."},{"id":"ENSMUSP00000044993","abundance":82.2,"rank":1121,"name":"Lsm7","annotation":"U6 snRNA-associated Sm-like protein LSm7; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA."},{"id":"ENSMUSP00000140941","abundance":82.2,"rank":1122,"name":"Tnnt2","annotation":"Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity."},{"id":"ENSMUSP00000105370","abundance":82.1,"rank":1123,"name":"Txn2","annotation":"Thioredoxin, mitochondrial; Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity; Belongs to the thioredoxin family."},{"id":"ENSMUSP00000014438","abundance":81.8,"rank":1124,"name":"Ndufa2","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000096096","abundance":81.7,"rank":1125,"name":"Snap91","annotation":"Clathrin coat assembly protein AP180; Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60- 70 nm coats; Belongs to the PICALM/SNAP91 family."},{"id":"ENSMUSP00000027111","abundance":81.5,"rank":1126,"name":"Ndufs1","annotation":"NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized (By sim [...] "},{"id":"ENSMUSP00000144827","abundance":81.5,"rank":1127,"name":"Suclg2","annotation":"Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit."},{"id":"ENSMUSP00000104533","abundance":81.4,"rank":1128,"name":"Acsl6","annotation":"Long-chain-fatty-acid--CoA ligase 6; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid (By similarity)."},{"id":"ENSMUSP00000096139","abundance":81.4,"rank":1129,"name":"Gsta1","annotation":"Glutathione S-transferase A1, N-terminally processed; Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fa [...] "},{"id":"ENSMUSP00000113685","abundance":81.1,"rank":1130,"name":"Srsf11","annotation":"Serine and arginine-rich-splicing factor 11."},{"id":"ENSMUSP00000001242","abundance":81,"rank":1131,"name":"Gatd3a","annotation":"Glutamine amidotransferase-like class 1 domain-containing protein 3A, mitochondrial."},{"id":"ENSMUSP00000078336","abundance":80.9,"rank":1132,"name":"Ablim1","annotation":"Actin-binding LIM protein 1; May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance."},{"id":"ENSMUSP00000006687","abundance":80.8,"rank":1133,"name":"Orm3","annotation":"Alpha-1-acid glycoprotein 3; Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain (By similarity). Appears to function in modulating the activity of the immune system during the acute-phase reaction."},{"id":"ENSMUSP00000029076","abundance":80.8,"rank":1134,"name":"Car3","annotation":"Carbonic anhydrase 3; Reversible hydration of carbon dioxide."},{"id":"ENSMUSP00000020099","abundance":80.6,"rank":1135,"name":"Cdk1","annotation":"Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, G [...] "},{"id":"ENSMUSP00000152046","abundance":80.6,"rank":1136,"name":"Txnrd1","annotation":"Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family."},{"id":"ENSMUSP00000103927","abundance":80.6,"rank":1137,"name":"Gmfg","annotation":"Glia maturation factor gamma; Belongs to the actin-binding proteins ADF family. GMF subfamily."},{"id":"ENSMUSP00000020107","abundance":80.5,"rank":1138,"name":"Atp2b1","annotation":"Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] "},{"id":"ENSMUSP00000125777","abundance":80.1,"rank":1139,"name":"Lck","annotation":"Proto-oncogene tyrosine-protein kinase LCK; Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associa [...] "},{"id":"ENSMUSP00000118305","abundance":80.1,"rank":1140,"name":"Gm44805","annotation":"Predicted gene 44805."},{"id":"ENSMUSP00000115173","abundance":80.1,"rank":1141,"name":"Apoc2","annotation":"Apolipoprotein C-II; Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase."},{"id":"ENSMUSP00000024932","abundance":79.7,"rank":1142,"name":"Atp6v0c","annotation":"V-type proton ATPase 16 kDa proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells."},{"id":"ENSMUSP00000113697","abundance":79.3,"rank":1143,"name":"Gtf2a2","annotation":"Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity)."},{"id":"ENSMUSP00000133649","abundance":79.3,"rank":1144,"name":"Syncrip","annotation":"Heterogeneous nuclear ribonucleoprotein Q; Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1 and isoform 2 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences (By similarity). Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to AP [...] "},{"id":"ENSMUSP00000134735","abundance":78.9,"rank":1145,"name":"Psme1","annotation":"Proteasome activator complex subunit 1; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome."},{"id":"ENSMUSP00000041538","abundance":78.8,"rank":1146,"name":"Eif1","annotation":"Eukaryotic translation initiation factor 1; Necessary for scanning and involved in initiation site selection. Promotes the assembly of 48S ribosomal complexes at the authentic initiation codon of a conventional capped mRNA (By similarity); Belongs to the SUI1 family."},{"id":"ENSMUSP00000016399","abundance":78.7,"rank":1147,"name":"Tubb1","annotation":"Tubulin beta-1 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). Belongs to the tubulin family."},{"id":"ENSMUSP00000005692","abundance":78.6,"rank":1148,"name":"Atp4a","annotation":"Potassium-transporting ATPase alpha chain 1; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily."},{"id":"ENSMUSP00000058757","abundance":78.5,"rank":1149,"name":"Ptpn11","annotation":"Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73."},{"id":"ENSMUSP00000032196","abundance":78.4,"rank":1150,"name":"Arl8b","annotation":"ADP-ribosylation factor-like protein 8B; Plays a role in lysosome motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. May play a role in chromosome segregation (By similarity)."},{"id":"ENSMUSP00000102926","abundance":78.4,"rank":1151,"name":"Hdgfl3","annotation":"Hepatoma-derived growth factor-related protein 3; Enhances DNA synthesis and may play a role in cell proliferation."},{"id":"ENSMUSP00000096510","abundance":78.2,"rank":1152,"name":"S100a16","annotation":"Protein S100-A16; Calcium-binding protein. Binds one calcium ion per monomer. Can promote differentiation of adipocytes (in vitro). Overexpression in 3T3-L1 preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake."},{"id":"ENSMUSP00000005234","abundance":78.1,"rank":1153,"name":"Wdr1","annotation":"WD repeat-containing protein 1; Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (By similarity). Enhances cofilin-mediated actin severing. Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (By similarity). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth at the postnatal and maintenance at the adult stage. Involved in neutrophil actin dynamics and migration. Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of pl [...] "},{"id":"ENSMUSP00000155269","abundance":78,"rank":1154,"name":"Gm5478","annotation":"Predicted pseudogene 5478; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000031788","abundance":78,"rank":1155,"name":"Hibadh","annotation":"3-hydroxyisobutyrate dehydrogenase, mitochondrial; Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily."},{"id":"ENSMUSP00000117569","abundance":77.9,"rank":1156,"name":"Myh1","annotation":"Myosin-1; Muscle contraction."},{"id":"ENSMUSP00000156878","abundance":77.9,"rank":1157,"name":"Gm49804","annotation":"Predicted gene, 49804."},{"id":"ENSMUSP00000112897","abundance":77.9,"rank":1158,"name":"Mthfd1l","annotation":"Monofunctional C1-tetrahydrofolate synthase, mitochondrial; May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family."},{"id":"ENSMUSP00000055122","abundance":77.9,"rank":1159,"name":"Epb41l2","annotation":"Band 4.1-like protein 2; Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase."},{"id":"ENSMUSP00000030456","abundance":77.6,"rank":1160,"name":"Nasp","annotation":"Nuclear autoantigenic sperm protein; Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and linker H1 histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA."},{"id":"ENSMUSP00000119242","abundance":77.5,"rank":1161,"name":"Atp2b4","annotation":"Plasma membrane calcium-transporting ATPase 4; Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (By similarity). By regulating sperm cell calcium homeostasis, may play a role in sperm motility ; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily."},{"id":"ENSMUSP00000081544","abundance":77.4,"rank":1162,"name":"Oat","annotation":"Ornithine aminotransferase, mitochondrial."},{"id":"ENSMUSP00000013842","abundance":77.1,"rank":1163,"name":"Pea15a","annotation":"Astrocytic phosphoprotein PEA-15; Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A- mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity)."},{"id":"ENSMUSP00000042967","abundance":77,"rank":1164,"name":"Ndufv1","annotation":"NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000043559","abundance":77,"rank":1165,"name":"Cisd1","annotation":"CDGSH iron-sulfur domain-containing protein 1; Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation. May be involved in Fe-S cluster shuttling and/or in redox reactions (By similarity). Belongs to the CISD protein family."},{"id":"ENSMUSP00000006435","abundance":76.9,"rank":1166,"name":"Atp6v1b2","annotation":"V-type proton ATPase subunit B, brain isoform; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells."},{"id":"ENSMUSP00000031131","abundance":76.9,"rank":1167,"name":"Uchl1","annotation":"Ubiquitin carboxyl-terminal hydrolase isozyme L1; Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins (Probable). This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity (By similarity)."},{"id":"ENSMUSP00000121557","abundance":76.3,"rank":1168,"name":"Ndufv2","annotation":"NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000099864","abundance":76.2,"rank":1169,"name":"Gapvd1","annotation":"GTPase-activating protein and VPS9 domain-containing protein 1; Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside th [...] "},{"id":"ENSMUSP00000059404","abundance":76.1,"rank":1170,"name":"Pura","annotation":"Transcriptional activator protein Pur-alpha; This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the c-Myc gene. May play a role in the initiation of DNA replication and in recombination."},{"id":"ENSMUSP00000032555","abundance":76.1,"rank":1171,"name":"Tomm40","annotation":"Mitochondrial import receptor subunit TOM40 homolog; Channel-forming protein essential for import of protein precursors into mitochondria."},{"id":"ENSMUSP00000125548","abundance":76.1,"rank":1172,"name":"Psma3","annotation":"Proteasome subunit alpha type-3; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] "},{"id":"ENSMUSP00000049355","abundance":76,"rank":1173,"name":"Gpi1","annotation":"Glucose-6-phosphate isomerase; In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (By similarity). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. Belongs to the GPI family."},{"id":"ENSMUSP00000137926","abundance":76,"rank":1174,"name":"Car1","annotation":"Carbonic anhydrase 1; Reversible hydration of carbon dioxide."},{"id":"ENSMUSP00000033634","abundance":75.5,"rank":1175,"name":"Acsl4","annotation":"Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family."},{"id":"ENSMUSP00000001620","abundance":75.4,"rank":1176,"name":"Fxr1","annotation":"Fragile X mental retardation syndrome-related protein 1; RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs."},{"id":"ENSMUSP00000086640","abundance":75.4,"rank":1177,"name":"Ppp2r2a","annotation":"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment."},{"id":"ENSMUSP00000129544","abundance":75.4,"rank":1178,"name":"Myh2","annotation":"Myosin, heavy polypeptide 2, skeletal muscle, adult; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000127903","abundance":75.2,"rank":1179,"name":"Hdlbp","annotation":"Vigilin; Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity)."},{"id":"ENSMUSP00000099653","abundance":75.1,"rank":1180,"name":"Eif3i","annotation":"Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] "},{"id":"ENSMUSP00000097754","abundance":75,"rank":1181,"name":"Krt76","annotation":"Keratin, type II cytoskeletal 2 oral; Probably contributes to terminal cornification."},{"id":"ENSMUSP00000062030","abundance":74.8,"rank":1182,"name":"H1f1","annotation":"Histone H1.1; Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)."},{"id":"ENSMUSP00000087118","abundance":74.8,"rank":1183,"name":"Mat2a","annotation":"S-adenosylmethionine synthase isoform type-2; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate."},{"id":"ENSMUSP00000137503","abundance":74.7,"rank":1184,"name":"Actr3","annotation":"Actin-related protein 3; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] "},{"id":"ENSMUSP00000125995","abundance":74.7,"rank":1185,"name":"Mb","annotation":"Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles."},{"id":"ENSMUSP00000101874","abundance":74.7,"rank":1186,"name":"Stx1b","annotation":"Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Belongs to the syntaxin family."},{"id":"ENSMUSP00000018632","abundance":74.6,"rank":1187,"name":"Myh4","annotation":"Myosin-4; Muscle contraction."},{"id":"ENSMUSP00000014578","abundance":74.6,"rank":1188,"name":"Plg","annotation":"Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] "},{"id":"ENSMUSP00000136858","abundance":74.5,"rank":1189,"name":"Prpf19","annotation":"Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] "},{"id":"ENSMUSP00000075709","abundance":74.5,"rank":1190,"name":"Sf3b4","annotation":"Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class [...] "},{"id":"ENSMUSP00000126840","abundance":74.5,"rank":1191,"name":"Myh7","annotation":"Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000060054","abundance":74.4,"rank":1192,"name":"Chd4","annotation":"Chromodomain-helicase-DNA-binding protein 4; Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones."},{"id":"ENSMUSP00000029644","abundance":74.3,"rank":1193,"name":"Ppa2","annotation":"Inorganic pyrophosphatase 2, mitochondrial; Hydrolyzes inorganic pyrophosphate. This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function. Belongs to the PPase family."},{"id":"ENSMUSP00000138250","abundance":74.3,"rank":1194,"name":"Xpnpep1","annotation":"Xaa-Pro aminopeptidase 1; Contributes to the degradation of bradykinin. Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro (By similarity)."},{"id":"ENSMUSP00000022148","abundance":74.2,"rank":1195,"name":"Mccc2","annotation":"Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial; Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism."},{"id":"ENSMUSP00000074204","abundance":74.2,"rank":1196,"name":"Wbp2","annotation":"WW domain-binding protein 2; Acts as transcriptional coactivator of estrogen and progesterone receptors (ESR1 and PGR) upon hormone activation. In presence of estrogen, binds to ESR1-responsive promoters. Required for YAP1 coactivation function on PGR activity. Synergizes with WBP2 in enhancing PGR activity (By similarity). Modulates expression of post- synaptic scaffolding proteins via regulation of ESR1, ESR2 and PGR."},{"id":"ENSMUSP00000023210","abundance":74.2,"rank":1197,"name":"Cyc1","annotation":"Cytochrome c1, heme protein, mitochondrial; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient ove [...] "},{"id":"ENSMUSP00000102050","abundance":74,"rank":1198,"name":"Arhgap17","annotation":"Rho GTPase-activating protein 17; Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent  [...] "},{"id":"ENSMUSP00000065542","abundance":73.8,"rank":1199,"name":"Chdh","annotation":"Choline dehydrogenase, mitochondrial; Belongs to the GMC oxidoreductase family."},{"id":"ENSMUSP00000127374","abundance":73.7,"rank":1200,"name":"Mgll","annotation":"Monoglyceride lipase; Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity)."},{"id":"ENSMUSP00000077273","abundance":73.7,"rank":1201,"name":"Asph","annotation":"Aspartyl/asparaginyl beta-hydroxylase; [Isoform 1]: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins; Belongs to the aspartyl/asparaginyl beta-hydroxylase family."},{"id":"ENSMUSP00000113761","abundance":73.6,"rank":1202,"name":"Pdcd5","annotation":"Programmed cell death protein 5; May function in the process of apoptosis; Belongs to the PDCD5 family."},{"id":"ENSMUSP00000082288","abundance":73.6,"rank":1203,"name":"Aldh6a1","annotation":"Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity)."},{"id":"ENSMUSP00000073541","abundance":73.2,"rank":1204,"name":"Dhcr7","annotation":"7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC)."},{"id":"ENSMUSP00000118416","abundance":73.1,"rank":1205,"name":"Gm20431","annotation":"Predicted gene 20431."},{"id":"ENSMUSP00000038961","abundance":73.1,"rank":1206,"name":"Gm11273","annotation":"Cytochrome c oxidase subunit 5B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] "},{"id":"ENSMUSP00000141554","abundance":73.1,"rank":1207,"name":"Cox5b","annotation":"Cytochrome c oxidase subunit 5B."},{"id":"ENSMUSP00000105531","abundance":72.8,"rank":1208,"name":"Tmed9","annotation":"Transmembrane emp24 domain-containing protein 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of t [...] "},{"id":"ENSMUSP00000113211","abundance":72.8,"rank":1209,"name":"Gm10639","annotation":"Glutathione S-transferase."},{"id":"ENSMUSP00000086139","abundance":72.8,"rank":1210,"name":"Adam22","annotation":"Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1."},{"id":"ENSMUSP00000013845","abundance":72.7,"rank":1211,"name":"Timm23","annotation":"Mitochondrial import inner membrane translocase subunit Tim23; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane."},{"id":"ENSMUSP00000052912","abundance":72.7,"rank":1212,"name":"Pdia6","annotation":"Protein disulfide-isomerase A6; May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (By similarity). May also regulate the UPR via the EIF2AK3 UPR sensor (By similarity). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (By similarity). Belongs to the protein disulfide isomerase family."},{"id":"ENSMUSP00000014913","abundance":72.6,"rank":1213,"name":"Psmb1","annotation":"Proteasome subunit beta type-1; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] "},{"id":"ENSMUSP00000045284","abundance":72.6,"rank":1214,"name":"Uqcrfs1","annotation":"Cytochrome b-c1 complex subunit Rieske, mitochondrial; [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b- c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and su [...] "},{"id":"ENSMUSP00000080159","abundance":72.6,"rank":1215,"name":"H2-Q4","annotation":"Histocompatibility 2, Q region locus 4; Belongs to the MHC class I family."},{"id":"ENSMUSP00000119065","abundance":72.5,"rank":1216,"name":"Srsf6","annotation":"Serine/arginine-rich splicing factor 6; Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre- mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing (By similarity); Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000027810","abundance":72.5,"rank":1217,"name":"Fh1","annotation":"Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable).  [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by- product of the urea cycle and amino-acid catabolism. Also plays a role in DNA repair by promoting non-homologous end-joining [...] "},{"id":"ENSMUSP00000112138","abundance":72.5,"rank":1218,"name":"Snap23","annotation":"Synaptosomal-associated protein 23; Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion."},{"id":"ENSMUSP00000120152","abundance":72.5,"rank":1219,"name":"Stat3","annotation":"Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (By similarity). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (By similarity). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes (By similarity). Activated by IL31 through IL31RA (By s [...] "},{"id":"ENSMUSP00000051619","abundance":72.5,"rank":1220,"name":"Mapk3","annotation":"Mitogen-activated protein kinase 3; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays a [...] "},{"id":"ENSMUSP00000030642","abundance":72.4,"rank":1221,"name":"Psmb2","annotation":"Proteasome subunit beta type-2; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] "},{"id":"ENSMUSP00000107927","abundance":72.3,"rank":1222,"name":"Lrpprc","annotation":"Leucine-rich PPR motif-containing protein, mitochondrial; May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mito [...] "},{"id":"ENSMUSP00000004646","abundance":72.3,"rank":1223,"name":"Coro1c","annotation":"Coronin-1C; Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitm [...] "},{"id":"ENSMUSP00000108483","abundance":72.2,"rank":1224,"name":"Arpc5l","annotation":"Actin-related protein 2/3 complex subunit 5-like protein; May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks."},{"id":"ENSMUSP00000113038","abundance":72.2,"rank":1225,"name":"Sept8","annotation":"Septin-8; Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (By similarity). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity)."},{"id":"ENSMUSP00000023085","abundance":72.1,"rank":1226,"name":"Ndufa6","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Required for proper complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000146474","abundance":72.1,"rank":1227,"name":"Nap1l4","annotation":"Nucleosome assembly protein 1-like 4; Acts as histone chaperone in nucleosome assembly. In condensing spermatids, mediates the loading of the heterodimer composed of histones H2AB1 and H2BC1/TH2B onto the nucleosomes, thereby promoting the replacement of histones to protamine in male germ cells."},{"id":"ENSMUSP00000022062","abundance":72,"rank":1228,"name":"Sdha","annotation":"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor. Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily."},{"id":"ENSMUSP00000033821","abundance":71.7,"rank":1229,"name":"F10","annotation":"Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting."},{"id":"ENSMUSP00000120976","abundance":71.7,"rank":1230,"name":"Hadha","annotation":"Trifunctional enzyme subunit alpha, mitochondrial; Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional en [...] "},{"id":"ENSMUSP00000027036","abundance":71.4,"rank":1231,"name":"Lypla1","annotation":"Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity); Belongs to the AB hydrolase superfamily. AB hydrolase 2 family."},{"id":"ENSMUSP00000107492","abundance":71.4,"rank":1232,"name":"Pdcd6ip","annotation":"Programmed cell death 6-interacting protein; Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires [...] "},{"id":"ENSMUSP00000088349","abundance":71.3,"rank":1233,"name":"Selenbp1","annotation":"Methanethiol oxidase; Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)."},{"id":"ENSMUSP00000109237","abundance":71.3,"rank":1234,"name":"Copg1","annotation":"Coatomer subunit gamma-1; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] "},{"id":"ENSMUSP00000102665","abundance":71.3,"rank":1235,"name":"Fmo5","annotation":"Dimethylaniline monooxygenase [N-oxide-forming] 5; In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme."},{"id":"ENSMUSP00000044166","abundance":71.1,"rank":1236,"name":"Leap2","annotation":"Liver-expressed antimicrobial peptide 2; Has an antimicrobial activity; Belongs to the LEAP2 family."},{"id":"ENSMUSP00000090909","abundance":71,"rank":1237,"name":"Ces3b","annotation":"Carboxylesterase 3B; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000009003","abundance":70.9,"rank":1238,"name":"Rala","annotation":"Ras-related protein Ral-A; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (By similarity). Th [...] "},{"id":"ENSMUSP00000020769","abundance":70.9,"rank":1239,"name":"Dbnl","annotation":"Drebrin-like protein; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that reg [...] "},{"id":"ENSMUSP00000081041","abundance":70.9,"rank":1240,"name":"Fgfr1","annotation":"Fibroblast growth factor receptor 1; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 lea [...] "},{"id":"ENSMUSP00000022842","abundance":70.8,"rank":1241,"name":"Cct5","annotation":"T-complex protein 1 subunit epsilon; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin."},{"id":"ENSMUSP00000049007","abundance":70.5,"rank":1242,"name":"Ctnna1","annotation":"Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] "},{"id":"ENSMUSP00000079098","abundance":70.5,"rank":1243,"name":"Epb41l3","annotation":"Band 4.1-like protein 3, N-terminally processed; Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5 (By similarity)."},{"id":"ENSMUSP00000024860","abundance":70.4,"rank":1244,"name":"Ehd3","annotation":"EH domain-containing protein 3; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes (By similarity). Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology (By similarity). Involved in the recycling of [...] "},{"id":"ENSMUSP00000039633","abundance":70.4,"rank":1245,"name":"Tln2","annotation":"Talin-2; As a major component of focal adhesion plaques that links integrin to the actin cytoskeleton, may play an important role in cell adhesion. Recruits PIP5K1C to focal adhesion plaques and strongly activates its kinase activity (By similarity)."},{"id":"ENSMUSP00000019354","abundance":70.4,"rank":1246,"name":"Atp6v1e1","annotation":"V-type proton ATPase subunit E 1; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells."},{"id":"ENSMUSP00000130992","abundance":70.4,"rank":1247,"name":"Gpd2","annotation":"Glycerol-3-phosphate dehydrogenase, mitochondrial."},{"id":"ENSMUSP00000112947","abundance":70.3,"rank":1248,"name":"Ppil3","annotation":"Peptidyl-prolyl cis-trans isomerase-like 3; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing (By similarity). Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily."},{"id":"ENSMUSP00000088358","abundance":70.2,"rank":1249,"name":"Selenbp2","annotation":"Selenium-binding protein 2; Selenium- and acetaminophen-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity)."},{"id":"ENSMUSP00000073161","abundance":70.2,"rank":1250,"name":"Nsa2","annotation":"Ribosome biogenesis protein NSA2 homolog; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity)."},{"id":"ENSMUSP00000031565","abundance":70.1,"rank":1251,"name":"Fscn1","annotation":"Fascin; Actin-binding protein that contains 2 major actin binding sites (By similarity). Organizes filamentous actin into parallel bundles. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (By similarity). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (By similarity)."},{"id":"ENSMUSP00000139480","abundance":70.1,"rank":1252,"name":"Eloc","annotation":"Elongin-C; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an  [...] "},{"id":"ENSMUSP00000028278","abundance":70,"rank":1253,"name":"Psmd14","annotation":"26S proteasome non-ATPase regulatory subunit 14; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cle [...] "},{"id":"ENSMUSP00000007317","abundance":69.5,"rank":1254,"name":"Krt19","annotation":"Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity)."},{"id":"ENSMUSP00000085192","abundance":69.5,"rank":1255,"name":"Col3a1","annotation":"Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12."},{"id":"ENSMUSP00000026538","abundance":69.5,"rank":1256,"name":"Echs1","annotation":"Enoyl-CoA hydratase, mitochondrial; Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate (By similarity). Has high substrate specificity for crotonyl-CoA and moderate specificity for acryloyl-CoA, 3-methylcrotonyl-CoA and methacrylyl-CoA. It is noteworthy that binds tiglyl-CoA, but hydrates only a small amount of this substrate (By similarity)."},{"id":"ENSMUSP00000096193","abundance":69.5,"rank":1257,"name":"Cox7a1","annotation":"Cytochrome c oxidase subunit 7A1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] "},{"id":"ENSMUSP00000031314","abundance":69.3,"rank":1258,"name":"Alb","annotation":"Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (B [...] "},{"id":"ENSMUSP00000078914","abundance":69.3,"rank":1259,"name":"Ufc1","annotation":"Ubiquitin-fold modifier-conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage; Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily."},{"id":"ENSMUSP00000127842","abundance":69.3,"rank":1260,"name":"Ap2a1","annotation":"AP-2 complex subunit alpha-1; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold  [...] "},{"id":"ENSMUSP00000022268","abundance":69.2,"rank":1261,"name":"Pdhb","annotation":"Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle."},{"id":"ENSMUSP00000137031","abundance":69.1,"rank":1262,"name":"Igkv4-62","annotation":"Ig kappa chain V-VI region NQ2-6.1."},{"id":"ENSMUSP00000019198","abundance":69,"rank":1263,"name":"Fis1","annotation":"Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission. May be not essential for the assembly of functional fission complexes and the subsequent membrane scission event. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission."},{"id":"ENSMUSP00000081547","abundance":69,"rank":1264,"name":"Bub3","annotation":"Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity [...] "},{"id":"ENSMUSP00000015877","abundance":68.8,"rank":1265,"name":"Capza2","annotation":"F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments."},{"id":"ENSMUSP00000057664","abundance":68.8,"rank":1266,"name":"Rab2a","annotation":"Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex."},{"id":"ENSMUSP00000046089","abundance":68.7,"rank":1267,"name":"Rab26","annotation":"Ras-related protein Rab-26; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similari [...] "},{"id":"ENSMUSP00000030769","abundance":68.5,"rank":1268,"name":"Psmc2","annotation":"26S proteasome regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with [...] "},{"id":"ENSMUSP00000139310","abundance":68.5,"rank":1269,"name":"Rab27a","annotation":"Ras-related protein Rab-27A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse."},{"id":"ENSMUSP00000007005","abundance":68.5,"rank":1270,"name":"Acat2","annotation":"Acetyl-CoA acetyltransferase, cytosolic; Involved in the biosynthetic pathway of cholesterol."},{"id":"ENSMUSP00000030207","abundance":68.4,"rank":1271,"name":"Psip1","annotation":"PC4 and SFRS1-interacting protein; Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity)."},{"id":"ENSMUSP00000023718","abundance":68.3,"rank":1272,"name":"Krt83","annotation":"Keratin 83; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000028892","abundance":68.3,"rank":1273,"name":"Idh3b","annotation":"Isocitrate dehydrogenase [NAD] subunit, mitochondrial."},{"id":"ENSMUSP00000083709","abundance":68.2,"rank":1274,"name":"Pxn","annotation":"Paxillin; Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family."},{"id":"ENSMUSP00000103222","abundance":68.2,"rank":1275,"name":"Srcin1","annotation":"SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity)."},{"id":"ENSMUSP00000100564","abundance":68.2,"rank":1276,"name":"Psme2b","annotation":"Proteasome activator complex subunit 2; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome."},{"id":"ENSMUSP00000123798","abundance":68.2,"rank":1277,"name":"Psme2","annotation":"Proteasome (prosome, macropain) activator subunit 2 (PA28 beta)."},{"id":"ENSMUSP00000040717","abundance":68.2,"rank":1278,"name":"Cox8a","annotation":"Cytochrome c oxidase subunit 8A, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] "},{"id":"ENSMUSP00000072154","abundance":68.2,"rank":1279,"name":"Yes1","annotation":"Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components su [...] "},{"id":"ENSMUSP00000029679","abundance":68,"rank":1280,"name":"Cks1b","annotation":"Cyclin-dependent kinases regulatory subunit 1; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family."},{"id":"ENSMUSP00000138019","abundance":68,"rank":1281,"name":"Cox4i1","annotation":"Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives tran [...] "},{"id":"ENSMUSP00000052908","abundance":67.9,"rank":1282,"name":"Micos13","annotation":"MICOS complex subunit MIC13; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MICOS10/MIC10 into the MICOS complex."},{"id":"ENSMUSP00000021306","abundance":67.8,"rank":1283,"name":"Eftud2","annotation":"116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity)."},{"id":"ENSMUSP00000112715","abundance":67.7,"rank":1284,"name":"Kif2a","annotation":"Kinesin-like protein KIF2A; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity)."},{"id":"ENSMUSP00000093615","abundance":67.6,"rank":1285,"name":"Pnp2","annotation":"Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate."},{"id":"ENSMUSP00000099453","abundance":67.4,"rank":1286,"name":"Acsf2","annotation":"Medium-chain acyl-CoA ligase ACSF2, mitochondrial; Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation; Belongs to the ATP-dependent AMP-binding enzyme family."},{"id":"ENSMUSP00000093077","abundance":67.4,"rank":1287,"name":"Mtch1","annotation":"Mitochondrial carrier homolog 1; Potential mitochondrial transporter. May play a role in apoptosis (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000041872","abundance":67.4,"rank":1288,"name":"Sfxn5","annotation":"Sideroflexin-5; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity). Transports citrate (By similarity)."},{"id":"ENSMUSP00000055535","abundance":67.4,"rank":1289,"name":"Ddx17","annotation":"Probable ATP-dependent RNA helicase DDX17; As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features. This function requires the RNA helicase activity. Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner. Affects splicing of mediators of steroid hormone signaling [...] "},{"id":"ENSMUSP00000041855","abundance":67.3,"rank":1290,"name":"C8g","annotation":"Complement component C8 gamma chain; C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol (By similarity)."},{"id":"ENSMUSP00000041152","abundance":67.3,"rank":1291,"name":"Spcs2","annotation":"Signal peptidase complex subunit 2; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum."},{"id":"ENSMUSP00000112846","abundance":67.2,"rank":1292,"name":"Scamp3","annotation":"Secretory carrier-associated membrane protein 3; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface; Belongs to the SCAMP family."},{"id":"ENSMUSP00000059973","abundance":67,"rank":1293,"name":"Creb1","annotation":"Cyclic AMP-responsive element-binding protein 1; Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Belongs to the bZIP family."},{"id":"ENSMUSP00000061474","abundance":67,"rank":1294,"name":"Srsf4","annotation":"Serine/arginine-rich splicing factor 4; Plays a role in alternative splice site selection during pre- mRNA splicing. Represses the splicing of MAPT/Tau exon 10 (By similarity); Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000034189","abundance":67,"rank":1295,"name":"Ces1c","annotation":"Carboxylesterase 1C; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Involved in the extracellular metabolism of lung surfactant; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000107848","abundance":67,"rank":1296,"name":"Gpm6b","annotation":"Neuronal membrane glycoprotein M6-b; May be involved in neural development. Involved in regulation of osteoblast function and bone formation. Involved in matrix vesicle release by osteoblasts; this function seems to involve maintenance of the actin cytoskeleton. May be involved in cellular trafficking of SERT and thereby in regulation of serotonin uptake. Belongs to the myelin proteolipid protein family."},{"id":"ENSMUSP00000004565","abundance":66.9,"rank":1297,"name":"Ralb","annotation":"Ras-related protein Ral-B; Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles (By similarity). Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells (By similarity). Required for suppression of apoptosis (By s [...] "},{"id":"ENSMUSP00000043543","abundance":66.9,"rank":1298,"name":"Ndufb10","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000025486","abundance":66.7,"rank":1299,"name":"Lmnb1","annotation":"Lamin-B1; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin."},{"id":"ENSMUSP00000000804","abundance":66.6,"rank":1300,"name":"Ddx3x","annotation":"ATP-dependent RNA helicase DDX3X; Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in transcription regulation. Positively regulates CDKN1A/WAF1/CIP1 t [...] "},{"id":"ENSMUSP00000099524","abundance":66.6,"rank":1301,"name":"Fbn1","annotation":"Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus  [...] "},{"id":"ENSMUSP00000050191","abundance":66.6,"rank":1302,"name":"Ubqln1","annotation":"Ubiquilin-1; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins UBXN4, VCP and HERPUD1 and may form a lin [...] "},{"id":"ENSMUSP00000072555","abundance":66.5,"rank":1303,"name":"Cyp2d10","annotation":"Cytochrome P450 2D10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000019625","abundance":66.4,"rank":1304,"name":"Myh8","annotation":"Myosin-8; Muscle contraction."},{"id":"ENSMUSP00000037039","abundance":66.4,"rank":1305,"name":"Tspo","annotation":"Translocator protein; Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism , but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis. Belongs to the TspO/BZRP family."},{"id":"ENSMUSP00000018274","abundance":66.4,"rank":1306,"name":"Csnk1d","annotation":"Casein kinase I isoform delta; Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, dete [...] "},{"id":"ENSMUSP00000039252","abundance":66.4,"rank":1307,"name":"Rdh7","annotation":"Retinol dehydrogenase 7; Acts on androgens and retinols, i.e. has steroid 3-alpha- and 17-beta-dehydrogenase and cis/trans-retinol catalytic activities."},{"id":"ENSMUSP00000022529","abundance":66.4,"rank":1308,"name":"Tkt","annotation":"Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate."},{"id":"ENSMUSP00000005923","abundance":66.2,"rank":1309,"name":"Psmb4","annotation":"Proteasome subunit beta type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] "},{"id":"ENSMUSP00000113051","abundance":65.8,"rank":1310,"name":"Hagh","annotation":"Hydroxyacylglutathione hydrolase, mitochondrial; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family."},{"id":"ENSMUSP00000004673","abundance":65.7,"rank":1311,"name":"Ndrg2","annotation":"Protein NDRG2; Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). Belongs to the NDRG family."},{"id":"ENSMUSP00000099488","abundance":65.6,"rank":1312,"name":"Snrpb","annotation":"Small nuclear ribonucleoprotein-associated protein B; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing."},{"id":"ENSMUSP00000100046","abundance":65.4,"rank":1313,"name":"Sec61a2","annotation":"Protein transport protein Sec61 subunit alpha isoform 2; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity)."},{"id":"ENSMUSP00000109795","abundance":65.3,"rank":1314,"name":"Crmp1","annotation":"Dihydropyrimidinase-related protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration (By similarity). May participate in cytokinesis (By similarity)."},{"id":"ENSMUSP00000033598","abundance":65.2,"rank":1315,"name":"Sh3bgrl","annotation":"SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family."},{"id":"ENSMUSP00000022419","abundance":65.2,"rank":1316,"name":"Ppif","annotation":"Peptidyl-prolyl cis-trans isomerase F, mitochondrial; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved  [...] "},{"id":"ENSMUSP00000006424","abundance":65,"rank":1317,"name":"Mob1b","annotation":"MOB kinase activator 1B; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] "},{"id":"ENSMUSP00000056525","abundance":65,"rank":1318,"name":"Krt81","annotation":"Keratin, type II cuticular Hb1."},{"id":"ENSMUSP00000047551","abundance":65,"rank":1319,"name":"Ephx1","annotation":"Epoxide hydrolase 1; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Belongs to the peptidase S33 family."},{"id":"ENSMUSP00000101669","abundance":65,"rank":1320,"name":"Yars","annotation":"Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000138350","abundance":65,"rank":1321,"name":"Ptprc","annotation":"Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity."},{"id":"ENSMUSP00000031286","abundance":64.8,"rank":1322,"name":"Crybb1","annotation":"Beta-crystallin B1B; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000027684","abundance":64.7,"rank":1323,"name":"Arl8a","annotation":"ADP-ribosylation factor-like protein 8A; Plays a role in lysosomes motility. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. May play a role in chromosome segregation (By similarity); Belongs to the small GTPase superfamily. Arf family."},{"id":"ENSMUSP00000024802","abundance":64.7,"rank":1324,"name":"Ppil1","annotation":"Peptidyl-prolyl cis-trans isomerase-like 1; Involved in pre-mRNA splicing as component of the spliceosome. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides."},{"id":"ENSMUSP00000130195","abundance":64.6,"rank":1325,"name":"St13","annotation":"Hsc70-interacting protein; One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity)."},{"id":"ENSMUSP00000056502","abundance":64.4,"rank":1326,"name":"Idh3g","annotation":"Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers."},{"id":"ENSMUSP00000053101","abundance":64.3,"rank":1327,"name":"Ppp3ca","annotation":"Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif (By similarity). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (By similarity). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to t [...] "},{"id":"ENSMUSP00000071756","abundance":64.3,"rank":1328,"name":"Hpcal1","annotation":"Hippocalcin-like protein 1; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation."},{"id":"ENSMUSP00000007216","abundance":64.2,"rank":1329,"name":"Ap2m1","annotation":"AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] "},{"id":"ENSMUSP00000005066","abundance":64.1,"rank":1330,"name":"Map2k1","annotation":"Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine resid [...] "},{"id":"ENSMUSP00000101225","abundance":64.1,"rank":1331,"name":"Cdk11b","annotation":"Cyclin-dependent kinase 11B; Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity- dependent manner. May act as a negative regulator of normal cell cycle progression; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."},{"id":"ENSMUSP00000031931","abundance":64,"rank":1332,"name":"2210010C04Rik","annotation":"RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000125761","abundance":64,"rank":1333,"name":"Matr3","annotation":"Matrin-3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs (By similarity)."},{"id":"ENSMUSP00000102901","abundance":63.8,"rank":1334,"name":"Vps25","annotation":"Vacuolar protein-sorting-associated protein 25; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL (By similarity); Belongs to the VPS25 family."},{"id":"ENSMUSP00000096777","abundance":63.8,"rank":1335,"name":"Eif2s2","annotation":"Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] "},{"id":"ENSMUSP00000113811","abundance":63.7,"rank":1336,"name":"Chchd7","annotation":"Coiled-coil-helix-coiled-coil-helix domain-containing protein 7; Belongs to the CHCHD7 family."},{"id":"ENSMUSP00000108987","abundance":63.6,"rank":1337,"name":"Cab39","annotation":"Calcium-binding protein 39; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity)."},{"id":"ENSMUSP00000129325","abundance":63.5,"rank":1338,"name":"Rpl3l","annotation":"Ribosomal protein L3-like; Belongs to the universal ribosomal protein uL3 family."},{"id":"ENSMUSP00000033540","abundance":63.4,"rank":1339,"name":"Vbp1","annotation":"Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity)."},{"id":"ENSMUSP00000104861","abundance":63.4,"rank":1340,"name":"Stau1","annotation":"Double-stranded RNA-binding protein Staufen homolog 1; Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site."},{"id":"ENSMUSP00000111127","abundance":63.3,"rank":1341,"name":"Tes","annotation":"Testin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity)."},{"id":"ENSMUSP00000004172","abundance":63.2,"rank":1342,"name":"Hmox2","annotation":"Heme oxygenase 2; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter."},{"id":"ENSMUSP00000000828","abundance":63.2,"rank":1343,"name":"Txnrd3","annotation":"Thioredoxin reductase 3; Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family."},{"id":"ENSMUSP00000091835","abundance":63.1,"rank":1344,"name":"Chchd2","annotation":"Coiled-coil-helix-coiled-coil-helix domain-containing protein 2; Transcription factor. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen)."},{"id":"ENSMUSP00000022734","abundance":63.1,"rank":1345,"name":"Dnajc3","annotation":"DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activi [...] "},{"id":"ENSMUSP00000069529","abundance":63,"rank":1346,"name":"Stx3","annotation":"Syntaxin-3; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family."},{"id":"ENSMUSP00000064655","abundance":63,"rank":1347,"name":"Fabp1","annotation":"Fatty acid-binding protein, liver; Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes. Binds cholesterol. Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport."},{"id":"ENSMUSP00000034848","abundance":63,"rank":1348,"name":"Psma4","annotation":"Proteasome subunit alpha type-4; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] "},{"id":"ENSMUSP00000083281","abundance":63,"rank":1349,"name":"Ap2s1","annotation":"AP-2 complex subunit sigma; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] "},{"id":"ENSMUSP00000030348","abundance":62.9,"rank":1350,"name":"Magoh","annotation":"Protein mago nashi homolog; Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components rem [...] "},{"id":"ENSMUSP00000067013","abundance":62.9,"rank":1351,"name":"Rhob","annotation":"Rho-related GTP-binding protein RhoB; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascul [...] "},{"id":"ENSMUSP00000079888","abundance":62.8,"rank":1352,"name":"Impdh2","annotation":"Inosine-5'-monophosphate dehydrogenase 2; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. Belongs to the IMPDH/GMPR family."},{"id":"ENSMUSP00000100575","abundance":62.8,"rank":1353,"name":"Igkv4-71","annotation":"Ig kappa chain V-VI region NQ2-17.4.1; Anti-2-phenyl oxazolone (PHOX) Antibody."},{"id":"ENSMUSP00000010205","abundance":62.8,"rank":1354,"name":"Gnat1","annotation":"Guanine nucleotide-binding protein G(t) subunit alpha-1; Functions as signal transducer for the rod photoreceptor RHO. Required for normal RHO-mediated light perception by the retina (By similarity). Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs), such as the photoreceptor RHO. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Activated RHO promotes GDP release and GTP binding. Signaling is mediated via downstream eff [...] "},{"id":"ENSMUSP00000042123","abundance":62.7,"rank":1355,"name":"Lasp1","annotation":"LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin- based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity)."},{"id":"ENSMUSP00000021913","abundance":62.7,"rank":1356,"name":"Auh","annotation":"Methylglutaconyl-CoA hydratase, mitochondrial; Catalyzes the conversion of 3-methylglutaconyl-CoA to 3- hydroxy-3-methylglutaryl-CoA (By similarity). Also has itaconyl-CoA hydratase activity by converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway (By similarity). The C5- dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite (By similarity). Has very low enoyl- CoA hydratase activity. Was originally identified as RNA-binding protein that binds in vitro to clustered 5'-AUUUA-3' motifs ; Belongs to the enoy [...] "},{"id":"ENSMUSP00000054452","abundance":62.6,"rank":1357,"name":"Mob1a","annotation":"MOB kinase activator 1A; Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellu [...] "},{"id":"ENSMUSP00000033182","abundance":62.5,"rank":1358,"name":"Ilk","annotation":"Integrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B."},{"id":"ENSMUSP00000036092","abundance":62.5,"rank":1359,"name":"Gm8909","annotation":"Predicted gene 8909; Belongs to the MHC class I family."},{"id":"ENSMUSP00000122103","abundance":62.4,"rank":1360,"name":"Slc25a12","annotation":"Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle."},{"id":"ENSMUSP00000008517","abundance":62.1,"rank":1361,"name":"Prpf31","annotation":"U4/U6 small nuclear ribonucleoprotein Prp31; Involved in pre-mRNA splicing as component of the spliceosome. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome."},{"id":"ENSMUSP00000067867","abundance":62,"rank":1362,"name":"Tfg","annotation":"Trk-fused protein."},{"id":"ENSMUSP00000047968","abundance":62,"rank":1363,"name":"S100b","annotation":"Protein S100-B; Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic pr [...] "},{"id":"ENSMUSP00000140324","abundance":62,"rank":1364,"name":"Ktn1","annotation":"Kinectin; Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin (By similarity)."},{"id":"ENSMUSP00000006235","abundance":61.9,"rank":1365,"name":"Ctsb","annotation":"Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000032882","abundance":61.9,"rank":1366,"name":"Ndufc2","annotation":"NADH dehydrogenase [ubiquinone] 1 subunit C2; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000038301","abundance":61.7,"rank":1367,"name":"Gdf7","annotation":"Growth/differentiation factor 7."},{"id":"ENSMUSP00000089948","abundance":61.7,"rank":1368,"name":"Mbd3","annotation":"Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases."},{"id":"ENSMUSP00000007139","abundance":61.7,"rank":1369,"name":"Eif1b","annotation":"Eukaryotic translation initiation factor 1b; Probably involved in translation."},{"id":"ENSMUSP00000004327","abundance":61.5,"rank":1370,"name":"G6pdx","annotation":"Glucose-6-phosphate 1-dehydrogenase X; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes."},{"id":"ENSMUSP00000128278","abundance":61.4,"rank":1371,"name":"Iqgap1","annotation":"Ras GTPase-activating-like protein IQGAP1; Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth. May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest."},{"id":"ENSMUSP00000100863","abundance":61.3,"rank":1372,"name":"Sarnp","annotation":"SAP domain-containing ribonucleoprotein; Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is  [...] "},{"id":"ENSMUSP00000014221","abundance":61.3,"rank":1373,"name":"Chp1","annotation":"Calcineurin B homologous protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane- type Na(+)/H(+) ex [...] "},{"id":"ENSMUSP00000044417","abundance":61.2,"rank":1374,"name":"Mrpl12","annotation":"39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family."},{"id":"ENSMUSP00000002091","abundance":61.2,"rank":1375,"name":"Bcap31","annotation":"B-cell receptor-associated protein 31; Functions as a chaperone protein. Is one of the most abundant endoplasmic reticulum (ER) proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation (ERAD). Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis."},{"id":"ENSMUSP00000074160","abundance":61.1,"rank":1376,"name":"Snrnp70","annotation":"U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1- snRNA."},{"id":"ENSMUSP00000072483","abundance":61,"rank":1377,"name":"Acadm","annotation":"Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase)."},{"id":"ENSMUSP00000096003","abundance":61,"rank":1378,"name":"Snrpn","annotation":"Small nuclear ribonucleoprotein-associated protein N; May be involved in tissue-specific alternative RNA processing events."},{"id":"ENSMUSP00000082346","abundance":60.9,"rank":1379,"name":"Morf4l1","annotation":"Mortality factor 4-like protein 1; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicativ [...] "},{"id":"ENSMUSP00000143190","abundance":60.9,"rank":1380,"name":"Rbm8a","annotation":"RNA-binding protein 8A; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain  [...] "},{"id":"ENSMUSP00000034689","abundance":60.9,"rank":1381,"name":"Pin1","annotation":"Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes. Displays a preference for an acidic residue N- terminal to the isomerized proline bond. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and [...] "},{"id":"ENSMUSP00000026625","abundance":60.6,"rank":1382,"name":"Clybl","annotation":"Citramalyl-CoA lyase, mitochondrial; Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway (By similarity). The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (By similarity). Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and [...] "},{"id":"ENSMUSP00000112665","abundance":60.6,"rank":1383,"name":"Ecm1","annotation":"Extracellular matrix protein 1; Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity (By similarity)."},{"id":"ENSMUSP00000042271","abundance":60.5,"rank":1384,"name":"Spag9","annotation":"C-Jun-amino-terminal kinase-interacting protein 4; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (By similarity)."},{"id":"ENSMUSP00000025250","abundance":60.5,"rank":1385,"name":"Bag6","annotation":"Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] "},{"id":"ENSMUSP00000106180","abundance":60.3,"rank":1386,"name":"Sord","annotation":"Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation. Has no activity on ethanol. Cannot use N [...] "},{"id":"ENSMUSP00000144904","abundance":60.2,"rank":1387,"name":"Ndufa9","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000028499","abundance":60.2,"rank":1388,"name":"Itgav","annotation":"Integrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G- D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essentia [...] "},{"id":"ENSMUSP00000125564","abundance":60.1,"rank":1389,"name":"Bud31","annotation":"Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity."},{"id":"ENSMUSP00000109646","abundance":59.9,"rank":1390,"name":"Map2","annotation":"Microtubule-associated protein 2; The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules."},{"id":"ENSMUSP00000125058","abundance":59.8,"rank":1391,"name":"Kcnab2","annotation":"Voltage-gated potassium channel subunit beta-2; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Modulates the functional properties of KCNA4 (By similarity). Modulates the functional proper [...] "},{"id":"ENSMUSP00000101215","abundance":59.8,"rank":1392,"name":"Esr1","annotation":"Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] "},{"id":"ENSMUSP00000066488","abundance":59.8,"rank":1393,"name":"Agt","annotation":"Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family."},{"id":"ENSMUSP00000101665","abundance":59.7,"rank":1394,"name":"Urah","annotation":"5-hydroxyisourate hydrolase; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily."},{"id":"ENSMUSP00000025127","abundance":59.6,"rank":1395,"name":"Mapre2","annotation":"Microtubule-associated protein RP/EB family member 2; May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity)."},{"id":"ENSMUSP00000014370","abundance":59.6,"rank":1396,"name":"Cacybp","annotation":"Calcyclin-binding protein; May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity)."},{"id":"ENSMUSP00000096173","abundance":59.6,"rank":1397,"name":"Rap1gds1","annotation":"RAP1, GTP-GDP dissociation stimulator 1."},{"id":"ENSMUSP00000022480","abundance":59.5,"rank":1398,"name":"Ogdhl","annotation":"Oxoglutarate dehydrogenase-like."},{"id":"ENSMUSP00000021063","abundance":59.5,"rank":1399,"name":"Psmd12","annotation":"26S proteasome non-ATPase regulatory subunit 12; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit p55 family."},{"id":"ENSMUSP00000046168","abundance":59.4,"rank":1400,"name":"Bphl","annotation":"Valacyclovir hydrolase; Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol (By similarity)."},{"id":"ENSMUSP00000014684","abundance":59.4,"rank":1401,"name":"U2af1","annotation":"Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity)."},{"id":"ENSMUSP00000101866","abundance":59,"rank":1402,"name":"Gaa","annotation":"Lysosomal alpha-glucosidase; Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans."},{"id":"ENSMUSP00000114434","abundance":59,"rank":1403,"name":"Pa2g4","annotation":"Proliferation-associated protein 2G4; May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1- regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved  [...] "},{"id":"ENSMUSP00000103656","abundance":58.9,"rank":1404,"name":"Ptrh2","annotation":"Peptidyl-tRNA hydrolase 2, mitochondrial; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis."},{"id":"ENSMUSP00000029414","abundance":58.8,"rank":1405,"name":"Ssr3","annotation":"Translocon-associated protein subunit gamma; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; Belongs to the TRAP-gamma family."},{"id":"ENSMUSP00000123700","abundance":58.7,"rank":1406,"name":"Hyou1","annotation":"Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding (By similarity)."},{"id":"ENSMUSP00000000727","abundance":58.6,"rank":1407,"name":"Rab5b","annotation":"Ras-related protein Rab-5B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000025166","abundance":58.6,"rank":1408,"name":"Cdh2","annotation":"Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic s [...] "},{"id":"ENSMUSP00000022980","abundance":58.3,"rank":1409,"name":"Ndufb9","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000014750","abundance":58.3,"rank":1410,"name":"Slc25a11","annotation":"Mitochondrial 2-oxoglutarate/malate carrier protein; Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (By similarity). Involved in the regulation of apoptosis. Belongs to the mi [...] "},{"id":"ENSMUSP00000105237","abundance":58.3,"rank":1411,"name":"Cpne1","annotation":"Copine-1; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Involved in the TNF- alpha receptor signaling pathway in a calcium-dependent manner. Exhibits calcium-dependent phospholipid binding properties. Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner. May recruit target proteins to the cell membrane in a calcium- dependent manner. May function in membrane trafficking. Involved in TNF-alpha-induced NF-kappa-B transcription [...] "},{"id":"ENSMUSP00000061012","abundance":58.3,"rank":1412,"name":"Hmgn1","annotation":"Non-histone chromosomal protein HMG-14; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2."},{"id":"ENSMUSP00000120518","abundance":58.1,"rank":1413,"name":"Rps27l","annotation":"40S ribosomal protein S27."},{"id":"ENSMUSP00000085775","abundance":58.1,"rank":1414,"name":"Atp2b3","annotation":"Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium."},{"id":"ENSMUSP00000130313","abundance":58.1,"rank":1415,"name":"Ssb","annotation":"Lupus La protein homolog; Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation."},{"id":"ENSMUSP00000042590","abundance":58.1,"rank":1416,"name":"Psma8","annotation":"Proteasome subunit alpha type-8; Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complexe that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds (Probable). Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis [...] "},{"id":"ENSMUSP00000000769","abundance":58,"rank":1417,"name":"Serpinf1","annotation":"Pigment epithelium-derived factor; Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity."},{"id":"ENSMUSP00000031524","abundance":58,"rank":1418,"name":"Acads","annotation":"Short-chain specific acyl-CoA dehydrogenase, mitochondrial; Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, short-chai [...] "},{"id":"ENSMUSP00000087611","abundance":58,"rank":1419,"name":"Ncald","annotation":"Neurocalcin-delta; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds three calcium ions (By similarity). Belongs to the recoverin family."},{"id":"ENSMUSP00000127250","abundance":57.9,"rank":1420,"name":"Mvp","annotation":"Major vault protein; Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity)."},{"id":"ENSMUSP00000136438","abundance":57.8,"rank":1421,"name":"Fkbp2","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP2; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides."},{"id":"ENSMUSP00000026907","abundance":57.7,"rank":1422,"name":"Klkb1","annotation":"Plasma kallikrein heavy chain; The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin."},{"id":"ENSMUSP00000155999","abundance":57.6,"rank":1423,"name":"Pacsin1","annotation":"Protein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell corte [...] "},{"id":"ENSMUSP00000017430","abundance":57.5,"rank":1424,"name":"Glod4","annotation":"Glyoxalase domain-containing protein 4."},{"id":"ENSMUSP00000037583","abundance":57.3,"rank":1425,"name":"Tmed10","annotation":"Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] "},{"id":"ENSMUSP00000025181","abundance":57.2,"rank":1426,"name":"H2-K1","annotation":"H-2 class I histocompatibility antigen, K-B alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family."},{"id":"ENSMUSP00000025239","abundance":57.1,"rank":1427,"name":"Bin1","annotation":"Myc box-dependent-interacting protein 1; Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of B [...] "},{"id":"ENSMUSP00000113657","abundance":57,"rank":1428,"name":"Stk38","annotation":"Serine/threonine-protein kinase 38; Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (By similarity)."},{"id":"ENSMUSP00000027495","abundance":56.9,"rank":1429,"name":"Sept2","annotation":"Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar- shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis [...] "},{"id":"ENSMUSP00000132850","abundance":56.9,"rank":1430,"name":"Sept2-2","annotation":"Septin 2."},{"id":"ENSMUSP00000119303","abundance":56.9,"rank":1431,"name":"Numb","annotation":"Protein numb homolog; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage."},{"id":"ENSMUSP00000053540","abundance":56.8,"rank":1432,"name":"Gstz1","annotation":"Maleylacetoacetate isomerase; Probable bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2- oxa-1, 3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with t-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid (By similarity). Belongs to the GST superfamily. Zeta family."},{"id":"ENSMUSP00000025961","abundance":56.8,"rank":1433,"name":"Prdx3","annotation":"Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides."},{"id":"ENSMUSP00000066210","abundance":56.8,"rank":1434,"name":"Elob","annotation":"Elongin-B; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an  [...] "},{"id":"ENSMUSP00000032307","abundance":56.7,"rank":1435,"name":"Magohb","annotation":"Protein mago nashi homolog 2; Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOH in the exon junction complex and in the nonsense-mediated decay (NMD) pathway."},{"id":"ENSMUSP00000089680","abundance":56.5,"rank":1436,"name":"Naca","annotation":"Nascent polypeptide-associated complex subunit alpha, muscle-specific form; Cardiac- and muscle-specific transcription factor. May act to regulate the expression of genes involved in the development of myotubes. Plays a critical role in ventricular cardiomyocyte expansion and regulates postnatal skeletal muscle growth and regeneration. Involved in the organized assembly of thick and thin filaments of myofibril sarcomeres."},{"id":"ENSMUSP00000022638","abundance":56.5,"rank":1437,"name":"Nefm","annotation":"Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber."},{"id":"ENSMUSP00000090844","abundance":56.4,"rank":1438,"name":"Ap1g1","annotation":"AP-1 complex subunit gamma-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules."},{"id":"ENSMUSP00000065089","abundance":56.4,"rank":1439,"name":"Aldh7a1","annotation":"Alpha-aminoadipic semialdehyde dehydrogenase; Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity)."},{"id":"ENSMUSP00000009789","abundance":56.3,"rank":1440,"name":"P4ha1","annotation":"Prolyl 4-hydroxylase subunit alpha-1; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins."},{"id":"ENSMUSP00000034590","abundance":56.3,"rank":1441,"name":"Tagln","annotation":"Transgelin; Actin cross-linking/gelling protein."},{"id":"ENSMUSP00000108841","abundance":56.3,"rank":1442,"name":"Sh3bgrl2","annotation":"SH3 domain-binding glutamic acid-rich-like protein 2."},{"id":"ENSMUSP00000000193","abundance":56.3,"rank":1443,"name":"Ccl2","annotation":"C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phospho [...] "},{"id":"ENSMUSP00000040321","abundance":56.3,"rank":1444,"name":"Ppp2r2d","annotation":"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] "},{"id":"ENSMUSP00000028981","abundance":56.1,"rank":1445,"name":"Mapre1","annotation":"Microtubule-associated protein RP/EB family member 1; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes cytoplasmic microtubule nucleation and elongation. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, a [...] "},{"id":"ENSMUSP00000022808","abundance":56.1,"rank":1446,"name":"Pabpn1","annotation":"Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription [...] "},{"id":"ENSMUSP00000001845","abundance":56,"rank":1447,"name":"Capns1","annotation":"Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction."},{"id":"ENSMUSP00000114873","abundance":56,"rank":1448,"name":"Bola2","annotation":"BolA-like protein 2; Acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins. Acts together with the monothiol glutaredoxin GLRX3; Belongs to the BolA/IbaG family."},{"id":"ENSMUSP00000004377","abundance":56,"rank":1449,"name":"Ptpn6","annotation":"Tyrosine-protein phosphatase non-receptor type 6; Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily."},{"id":"ENSMUSP00000078436","abundance":56,"rank":1450,"name":"Aadat","annotation":"Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial; Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro) (By similarity). Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family."},{"id":"ENSMUSP00000090086","abundance":55.9,"rank":1451,"name":"Tfam","annotation":"Transcription factor A, mitochondrial; Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymeras [...] "},{"id":"ENSMUSP00000025955","abundance":55.8,"rank":1452,"name":"Eif3a","annotation":"Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] "},{"id":"ENSMUSP00000002452","abundance":55.8,"rank":1453,"name":"Ndufa11","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000021412","abundance":55.8,"rank":1454,"name":"Psma6","annotation":"Proteasome subunit alpha type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pr [...] "},{"id":"ENSMUSP00000029120","abundance":55.8,"rank":1455,"name":"Raly","annotation":"RNA-binding protein Raly; RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis. May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (By similarity)."},{"id":"ENSMUSP00000025774","abundance":55.7,"rank":1456,"name":"Sf3b2","annotation":"Splicing factor 3b, subunit 2."},{"id":"ENSMUSP00000020531","abundance":55.7,"rank":1457,"name":"Hba-x","annotation":"Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family."},{"id":"ENSMUSP00000045073","abundance":55.7,"rank":1458,"name":"Sf3b3","annotation":"Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...] "},{"id":"ENSMUSP00000058391","abundance":55.7,"rank":1459,"name":"Rap2c","annotation":"Ras-related protein Rap-2c; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription."},{"id":"ENSMUSP00000062576","abundance":55.7,"rank":1460,"name":"Nucks1","annotation":"Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1."},{"id":"ENSMUSP00000066516","abundance":55.7,"rank":1461,"name":"Khdrbs1","annotation":"KH domain-containing, RNA-binding, signal transduction-associated protein 1; Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates [...] "},{"id":"ENSMUSP00000015829","abundance":55.5,"rank":1462,"name":"Acadsb","annotation":"Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2- methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity)."},{"id":"ENSMUSP00000048357","abundance":55.4,"rank":1463,"name":"Serpina10","annotation":"Protein Z-dependent protease inhibitor; Inhibits activity of the coagulation protease factor Xa in the presence of PROZ, calcium and phospholipids. Also inhibits factor XIa in the absence of cofactors (By similarity)."},{"id":"ENSMUSP00000021091","abundance":55.3,"rank":1464,"name":"Pafah1b1","annotation":"Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] "},{"id":"ENSMUSP00000119806","abundance":55.1,"rank":1465,"name":"Hikeshi","annotation":"Protein Hikeshi; Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin- dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus (By similarity). May also be indirectly required for organization and/or function of the secretory apparatus in Clara cells in lung."},{"id":"ENSMUSP00000100912","abundance":55.1,"rank":1466,"name":"Syt1","annotation":"Synaptotagmin-1; Calcium sensor that participates in triggering neurotransmitter release at the synapse. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)- dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neur [...] "},{"id":"ENSMUSP00000027381","abundance":55,"rank":1467,"name":"Pecr","annotation":"Peroxisomal trans-2-enoyl-CoA reductase; Participates in chain elongation of fatty acids. Has no 2,4- dienoyl-CoA reductase activity (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000113341","abundance":54.9,"rank":1468,"name":"Csnk1e","annotation":"Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation."},{"id":"ENSMUSP00000158561","abundance":54.9,"rank":1469,"name":"Atp5md","annotation":"ATP synthase membrane subunit DAPIT, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism [...] "},{"id":"ENSMUSP00000087457","abundance":54.7,"rank":1470,"name":"Itgb1","annotation":"Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] "},{"id":"ENSMUSP00000103958","abundance":54.6,"rank":1471,"name":"Rab34","annotation":"Ras-related protein Rab-34; Protein transport. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity). Involved in the redistribution of lysosomes to the peri- Golgi region. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function."},{"id":"ENSMUSP00000099416","abundance":54.5,"rank":1472,"name":"Krt35","annotation":"Keratin, type I cuticular Ha5."},{"id":"ENSMUSP00000136516","abundance":54.5,"rank":1473,"name":"Igkv4-54","annotation":"Immunoglobulin kappa chain variable 4-54."},{"id":"ENSMUSP00000130696","abundance":54.5,"rank":1474,"name":"Myo18a","annotation":"Unconventional myosin-XVIIIa; May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (By similarity). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact. Regulates t [...] "},{"id":"ENSMUSP00000081011","abundance":54.5,"rank":1475,"name":"Gpx3","annotation":"Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione."},{"id":"ENSMUSP00000020653","abundance":54.4,"rank":1476,"name":"Sar1b","annotation":"GTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex."},{"id":"ENSMUSP00000112145","abundance":54.3,"rank":1477,"name":"Hpca","annotation":"Neuron-specific calcium-binding protein hippocalcin; Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases; Belongs to the recoverin family."},{"id":"ENSMUSP00000043583","abundance":54.3,"rank":1478,"name":"Bclaf1","annotation":"Bcl-2-associated transcription factor 1; Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA (By similarity)."},{"id":"ENSMUSP00000147737","abundance":54.3,"rank":1479,"name":"Srek1","annotation":"Splicing regulatory glutamine/lysine-rich protein 1; Participates in the regulation of alternative splicing by modulating the activity of other splice facors. Inhibits the splicing activity of SFRS1, SFRS2 and SFRS6. Augments the splicing activity of SFRS3 (By similarity); Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000003906","abundance":54.3,"rank":1480,"name":"Farsa","annotation":"Phenylalanine--tRNA ligase alpha subunit."},{"id":"ENSMUSP00000064755","abundance":54.2,"rank":1481,"name":"Phgdh","annotation":"D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Does not catalyze the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate and the reversible oxidation of (S)-malate to oxaloacetate."},{"id":"ENSMUSP00000058237","abundance":54.1,"rank":1482,"name":"S100a1","annotation":"Protein S100-A1; Probably acts as a Ca(2+) signal transducer. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity."},{"id":"ENSMUSP00000093644","abundance":54,"rank":1483,"name":"Vti1a","annotation":"Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non-conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be concerned with increased secretion of cytokines associated with ce [...] "},{"id":"ENSMUSP00000064699","abundance":54,"rank":1484,"name":"Vapb","annotation":"Vesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation."},{"id":"ENSMUSP00000096701","abundance":54,"rank":1485,"name":"Pabpc1l","annotation":"Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family."},{"id":"ENSMUSP00000102570","abundance":53.8,"rank":1486,"name":"Myl4","annotation":"Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium."},{"id":"ENSMUSP00000099482","abundance":53.8,"rank":1487,"name":"Itpa","annotation":"Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family."},{"id":"ENSMUSP00000071939","abundance":53.8,"rank":1488,"name":"Entpd5","annotation":"Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thia [...] "},{"id":"ENSMUSP00000071843","abundance":53.7,"rank":1489,"name":"H2-Q7","annotation":"H-2 class I histocompatibility antigen, Q7 alpha chain; Involved in the presentation of foreign antigens to the immune system."},{"id":"ENSMUSP00000030561","abundance":53.5,"rank":1490,"name":"Gnat3","annotation":"Guanine nucleotide-binding protein G(t) subunit alpha-3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP- phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultim [...] "},{"id":"ENSMUSP00000096954","abundance":53.5,"rank":1491,"name":"Sfr1","annotation":"Swi5-dependent recombination DNA repair protein 1 homolog; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Acts as a transcriptional modulator for ESR1. Belongs to the SFR1/MEI5 family."},{"id":"ENSMUSP00000071426","abundance":53.5,"rank":1492,"name":"Fam136a","annotation":"Protein FAM136A; Belongs to the FAM136 family."},{"id":"ENSMUSP00000108229","abundance":53.4,"rank":1493,"name":"M6pr","annotation":"Cation-dependent mannose-6-phosphate receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex."},{"id":"ENSMUSP00000030051","abundance":53.4,"rank":1494,"name":"Txn1","annotation":"Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status  [...] "},{"id":"ENSMUSP00000035261","abundance":53.3,"rank":1495,"name":"D1Pas1","annotation":"Putative ATP-dependent RNA helicase Pl10; Putative ATP-dependent RNA helicase. Possible role in a key step of the spermatogenic process; Belongs to the DEAD box helicase family. DDX3/DED1 subfamily."},{"id":"ENSMUSP00000021595","abundance":53.2,"rank":1496,"name":"Psmc1","annotation":"26S proteasome regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with [...] "},{"id":"ENSMUSP00000031663","abundance":53.2,"rank":1497,"name":"C8b","annotation":"Complement component C8 beta chain; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family."},{"id":"ENSMUSP00000140275","abundance":53.2,"rank":1498,"name":"Kcnma1","annotation":"Calcium-activated potassium channel subunit alpha-1; Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in t [...] "},{"id":"ENSMUSP00000005406","abundance":53.1,"rank":1499,"name":"App","annotation":"Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G [...] "},{"id":"ENSMUSP00000025762","abundance":52.8,"rank":1500,"name":"Banf1","annotation":"Barrier-to-autointegration factor, N-terminally processed; Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non- specific dsDNA-binding sites which may promote DNA cross-bridging. Belongs to the BAF family."},{"id":"ENSMUSP00000021940","abundance":52.8,"rank":1501,"name":"Lman2","annotation":"Vesicular integral-membrane protein VIP36; Plays a role as an intracellular lectin in the early secretory pathway. Interacts with N-acetyl-D-galactosamine and high- mannose type glycans and may also bind to O-linked glycans. Involved in the transport and sorting of glycoproteins carrying high mannose-type glycans (By similarity)."},{"id":"ENSMUSP00000102737","abundance":52.8,"rank":1502,"name":"Elavl2","annotation":"ELAV-like protein 2; RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs. Seems to recognize a GAAA motif. Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR ; Belongs to the RRM elav family."},{"id":"ENSMUSP00000027973","abundance":52.8,"rank":1503,"name":"Sephs1","annotation":"Selenide, water dikinase 1; Synthesizes selenophosphate from selenide and ATP; Belongs to the selenophosphate synthase 1 family. Class II subfamily."},{"id":"ENSMUSP00000068267","abundance":52.6,"rank":1504,"name":"Strap","annotation":"Serine-threonine kinase receptor-associated protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICl [...] "},{"id":"ENSMUSP00000139684","abundance":52.6,"rank":1505,"name":"Bckdhb","annotation":"2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3)."},{"id":"ENSMUSP00000031103","abundance":52.5,"rank":1506,"name":"Ugdh","annotation":"UDP-glucose 6-dehydrogenase; Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans ; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family."},{"id":"ENSMUSP00000100038","abundance":52.5,"rank":1507,"name":"Aco1","annotation":"Cytoplasmic aconitate hydratase; Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding; Belongs to the aconitase/IPM isomerase family."},{"id":"ENSMUSP00000017610","abundance":52.4,"rank":1508,"name":"Timp2","annotation":"Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family."},{"id":"ENSMUSP00000017975","abundance":52.4,"rank":1509,"name":"Rab5a","annotation":"Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] "},{"id":"ENSMUSP00000147813","abundance":52.4,"rank":1510,"name":"Gm45713","annotation":"Predicted gene 45713; Belongs to the universal ribosomal protein uL13 family."},{"id":"ENSMUSP00000073261","abundance":52.3,"rank":1511,"name":"Mtx1","annotation":"Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development."},{"id":"ENSMUSP00000053962","abundance":52.3,"rank":1512,"name":"Lcn2","annotation":"Neutrophil gelatinase-associated lipocalin; Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association o [...] "},{"id":"ENSMUSP00000124625","abundance":52.3,"rank":1513,"name":"Wars","annotation":"Tryptophan--tRNA ligase, cytoplasmic; T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity)."},{"id":"ENSMUSP00000106534","abundance":52.3,"rank":1514,"name":"Arhgef7","annotation":"Rho guanine nucleotide exchange factor 7; Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity)."},{"id":"ENSMUSP00000029386","abundance":52,"rank":1515,"name":"Etfdh","annotation":"Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone."},{"id":"ENSMUSP00000104414","abundance":52,"rank":1516,"name":"Mrpl55","annotation":"39S ribosomal protein L55, mitochondrial."},{"id":"ENSMUSP00000020397","abundance":52,"rank":1517,"name":"Snrpd3","annotation":"Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing."},{"id":"ENSMUSP00000088723","abundance":51.9,"rank":1518,"name":"Slc25a31","annotation":"ADP/ATP translocase 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May serve to mediate energy generating and energy consuming processes in the distal flagellum, possibly as a nucleotide shuttle between flagellar glycolysis, protein phosphorylation and mechanisms of motility."},{"id":"ENSMUSP00000109190","abundance":51.9,"rank":1519,"name":"Fnbp1","annotation":"Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the  [...] "},{"id":"ENSMUSP00000033185","abundance":51.8,"rank":1520,"name":"Hpx","annotation":"Hemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation."},{"id":"ENSMUSP00000128696","abundance":51.8,"rank":1521,"name":"Cndp2","annotation":"Cytosolic non-specific dipeptidase; Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Catalyzes the production of N- lactoyl-amino acids from lactate and amino acids by reverse proteolysis."},{"id":"ENSMUSP00000039046","abundance":51.5,"rank":1522,"name":"Cpq","annotation":"Carboxypeptidase Q; Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor (By similarity)."},{"id":"ENSMUSP00000032440","abundance":51.5,"rank":1523,"name":"Sec13","annotation":"Protein SEC13 homolog; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum ; Belongs to the WD repeat SEC13 family."},{"id":"ENSMUSP00000003071","abundance":51.4,"rank":1524,"name":"Apoc4","annotation":"Apolipoprotein C-IV; May participate in lipoprotein metabolism."},{"id":"ENSMUSP00000026148","abundance":51.4,"rank":1525,"name":"Cbr2","annotation":"Carbonyl reductase [NADPH] 2; May function in the pulmonary metabolism of endogenous carbonyl compounds, such as aliphatic aldehydes and ketones derived from lipid peroxidation, 3-ketosteroids and fatty aldehydes, as well as in xenobiotic metabolism."},{"id":"ENSMUSP00000129224","abundance":51.4,"rank":1526,"name":"Synj2bp","annotation":"Synaptojanin-2-binding protein; Isoform 1 regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction. Isoform 2 and isoform 3 show a stimulatory affect on activin-induced signal transduction and enhance activin type 2 expression at the cell surface."},{"id":"ENSMUSP00000037341","abundance":51.4,"rank":1527,"name":"Ndufb7","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000001186","abundance":51.4,"rank":1528,"name":"Snrnp27","annotation":"U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein; May play a role in mRNA splicing; Belongs to the SNUT3 family."},{"id":"ENSMUSP00000139571","abundance":51.3,"rank":1529,"name":"Slc25a13","annotation":"Calcium-binding mitochondrial carrier protein Aralar2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle."},{"id":"ENSMUSP00000052373","abundance":51.3,"rank":1530,"name":"Csl","annotation":"Citrate synthase; Belongs to the citrate synthase family."},{"id":"ENSMUSP00000073664","abundance":51.3,"rank":1531,"name":"Negr1","annotation":"Neuronal growth regulator 1; May be involved in cell-adhesion. May function as a trans- neural growth-promoting factor in regenerative axon sprouting in the mammalian brain."},{"id":"ENSMUSP00000027921","abundance":51.3,"rank":1532,"name":"Iars2","annotation":"Isoleucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000034989","abundance":51.2,"rank":1533,"name":"Me1","annotation":"NADP-dependent malic enzyme."},{"id":"ENSMUSP00000110349","abundance":51.2,"rank":1534,"name":"Pi16","annotation":"Peptidase inhibitor 16; May inhibit cardiomyocyte growth."},{"id":"ENSMUSP00000075953","abundance":51.1,"rank":1535,"name":"Ndufa3","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000041299","abundance":51,"rank":1536,"name":"Usp5","annotation":"Ubiquitin carboxyl-terminal hydrolase 5; Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys- 48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity (By similarity)."},{"id":"ENSMUSP00000030742","abundance":51,"rank":1537,"name":"Mecr","annotation":"Enoyl-[acyl-carrier-protein] reductase, mitochondrial; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Has a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2-decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). Belongs to the zinc-containing alcohol dehydrogenase family. Quin [...] "},{"id":"ENSMUSP00000125172","abundance":51,"rank":1538,"name":"Atp5o-2","annotation":"ATP synthase, H+-transporting, mitochondrial F1 complex, O subunit."},{"id":"ENSMUSP00000079722","abundance":50.9,"rank":1539,"name":"Thrap3","annotation":"Thyroid hormone receptor-associated protein 3; Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin- D1/CCND1 mRNA  [...] "},{"id":"ENSMUSP00000127774","abundance":50.9,"rank":1540,"name":"Eif4b","annotation":"Eukaryotic translation initiation factor 4B; Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F (By similarity)."},{"id":"ENSMUSP00000069209","abundance":50.9,"rank":1541,"name":"Ephx2","annotation":"Bifunctional epoxide hydrolase 2; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy- hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy- hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-e [...] "},{"id":"ENSMUSP00000084445","abundance":50.9,"rank":1542,"name":"Ociad2","annotation":"OCIA domain-containing protein 2."},{"id":"ENSMUSP00000133404","abundance":50.8,"rank":1543,"name":"Ppp2r1b","annotation":"Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit."},{"id":"ENSMUSP00000002805","abundance":50.7,"rank":1544,"name":"Naa20","annotation":"N-alpha-acetyltransferase 20; Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration."},{"id":"ENSMUSP00000021082","abundance":50.6,"rank":1545,"name":"Nt5c","annotation":"5'(3')-deoxyribonucleotidase, cytosolic type; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP."},{"id":"ENSMUSP00000034552","abundance":50.6,"rank":1546,"name":"Fdx1","annotation":"Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. Belongs to the adrenodoxin/putidaredoxin family."},{"id":"ENSMUSP00000009693","abundance":50.5,"rank":1547,"name":"Srp14","annotation":"Signal recognition particle 14 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding."},{"id":"ENSMUSP00000015236","abundance":50.4,"rank":1548,"name":"Edf1","annotation":"Endothelial differentiation-related factor 1; Transcriptional coactivator stimulating NR5A1 and ligand- dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity)."},{"id":"ENSMUSP00000108927","abundance":50.4,"rank":1549,"name":"Tomm6","annotation":"Mitochondrial import receptor subunit TOM6 homolog; Belongs to the Tom6 family."},{"id":"ENSMUSP00000027432","abundance":50.3,"rank":1550,"name":"Psmd1","annotation":"26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family."},{"id":"ENSMUSP00000004784","abundance":50.3,"rank":1551,"name":"Cnn2","annotation":"Calponin-2; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity."},{"id":"ENSMUSP00000059501","abundance":50.3,"rank":1552,"name":"Vamp8","annotation":"Vesicle-associated membrane protein 8; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex (By similarity). Also required for dense-granule secretion in plat [...] "},{"id":"ENSMUSP00000111098","abundance":50.2,"rank":1553,"name":"Cask","annotation":"Peripheral plasma membrane protein CASK; Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1; In the N-terminal section; belongs to the protein kinase  [...] "},{"id":"ENSMUSP00000144119","abundance":50.2,"rank":1554,"name":"Mpv17","annotation":"Protein Mpv17; Non-selective channel that modulates the membrane potential under normal conditions and oxidative stress, and is involved in mitochondrial homeostasis (By similarity). Involved in mitochondrial deoxynucleoside triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA) maintenance. May be involved in the regulation of reactive oxygen species metabolism and the control of oxidative phosphorylation (Probable); Belongs to the peroxisomal membrane protein PXMP2/4 family."},{"id":"ENSMUSP00000099509","abundance":50.2,"rank":1555,"name":"Snrnp200","annotation":"U5 small nuclear ribonucleoprotein 200 kDa helicase; Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome."},{"id":"ENSMUSP00000016072","abundance":50.1,"rank":1556,"name":"Rrbp1","annotation":"Ribosome-binding protein 1; Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane."},{"id":"ENSMUSP00000100464","abundance":50.1,"rank":1557,"name":"Iglc2","annotation":"Ig lambda-2 chain C region."},{"id":"ENSMUSP00000099739","abundance":50.1,"rank":1558,"name":"H2-T23","annotation":"H-2 class I histocompatibility antigen, D-37 alpha chain; Involved in the presentation of foreign antigens to the immune system."},{"id":"ENSMUSP00000007318","abundance":50.1,"rank":1559,"name":"Krt31","annotation":"Keratin, type I cuticular Ha1."},{"id":"ENSMUSP00000079107","abundance":50.1,"rank":1560,"name":"Ppm1b","annotation":"Protein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF- alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family."},{"id":"ENSMUSP00000030400","abundance":50.1,"rank":1561,"name":"Mycbp","annotation":"c-Myc-binding protein; May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC (By similarity). Belongs to the AMY1 family."},{"id":"ENSMUSP00000064385","abundance":50,"rank":1562,"name":"S100a8","annotation":"Protein S100-A8; S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH- oxidase. Activates NADPH-oxidase by facilitat [...] "},{"id":"ENSMUSP00000106242","abundance":50,"rank":1563,"name":"Hypk","annotation":"Huntingtin-interacting protein K; Has a chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT. Protects against HTT polyQ-mediated apoptosis in neuronal cells (By similarity). Regulator of the N- terminal acetyltransferase NAA10-NAA15 complex (By similarity). Has been in one study shown to be required for optimal NAA10-NAA15 complex- mediated N-terminal acetylation (By similarity). However, has been shown in another study to act in vitro as an inhibitor of NAA10-NAA15 complex-mediated N-terminal acetylation (By similarity)."},{"id":"ENSMUSP00000104485","abundance":50,"rank":1564,"name":"Atox1","annotation":"Copper transport protein ATOX1; Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense (By similarity); Belongs to the ATX1 family."},{"id":"ENSMUSP00000003038","abundance":49.9,"rank":1565,"name":"Ap2a2","annotation":"AP-2 complex subunit alpha-2; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold  [...] "},{"id":"ENSMUSP00000128421","abundance":49.9,"rank":1566,"name":"Ddx6","annotation":"Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, plays a role in mRNA decapping (By similarity). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts ; Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily."},{"id":"ENSMUSP00000108075","abundance":49.9,"rank":1567,"name":"Sh3kbp1","annotation":"SH3 domain-containing kinase-binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3- kinase ac [...] "},{"id":"ENSMUSP00000021930","abundance":49.7,"rank":1568,"name":"Sfxn1","annotation":"Sideroflexin-1; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway (By similarity). Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors (By similarity). Transports both D-serine and L-serine (By similarity). Also able to transport other amino-acids, such as alanine (By similarity). May be indirectly involved in the transport of a component required for iron utilization into or out [...] "},{"id":"ENSMUSP00000016571","abundance":49.7,"rank":1569,"name":"Ndufa1","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000027478","abundance":49.7,"rank":1570,"name":"Ndufa10","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000118918","abundance":49.6,"rank":1571,"name":"Ndufb2","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000056785","abundance":49.5,"rank":1572,"name":"Nup62","annotation":"Nuclear pore glycoprotein p62; Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C- terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex. Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation. It might be involved in protein recruitment to the centrosome after nuclear breakdown. Belongs to the nucleoporin NSP [...] "},{"id":"ENSMUSP00000054881","abundance":49.4,"rank":1573,"name":"Higd1a","annotation":"HIG1 domain family member 1A, mitochondrial; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May play a role in the assembly of respiratory supercomplexes (By similarity)."},{"id":"ENSMUSP00000095195","abundance":49.4,"rank":1574,"name":"Srgap2","annotation":"SLIT-ROBO Rho GTPase-activating protein 2; RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral c [...] "},{"id":"ENSMUSP00000108004","abundance":49.4,"rank":1575,"name":"Cryba4","annotation":"Beta-crystallin A4; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000021314","abundance":49.4,"rank":1576,"name":"Nmt1","annotation":"Glycylpeptide N-tetradecanoyltransferase 1; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. Required for normal embryogenesis."},{"id":"ENSMUSP00000017920","abundance":49.3,"rank":1577,"name":"Crk","annotation":"Adapter molecule crk; [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling."},{"id":"ENSMUSP00000100771","abundance":49.2,"rank":1578,"name":"Sf3b5","annotation":"Splicing factor 3B subunit 5; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA."},{"id":"ENSMUSP00000121111","abundance":49,"rank":1579,"name":"Map2k2","annotation":"Dual specificity mitogen-activated protein kinase kinase 2; Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (By similarity)."},{"id":"ENSMUSP00000039797","abundance":48.9,"rank":1580,"name":"Prkar2b","annotation":"cAMP-dependent protein kinase type II-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase."},{"id":"ENSMUSP00000080767","abundance":48.9,"rank":1581,"name":"Dut","annotation":"Deoxyuridine triphosphatase."},{"id":"ENSMUSP00000028005","abundance":48.9,"rank":1582,"name":"Mgst3","annotation":"Microsomal glutathione S-transferase 3; Catalyzes oxydation of hydroxy-fatty acids. May participate to the lipid metabolism; Belongs to the MAPEG family."},{"id":"ENSMUSP00000054856","abundance":48.8,"rank":1583,"name":"Uqcr10","annotation":"Cytochrome b-c1 complex subunit 9; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inn [...] "},{"id":"ENSMUSP00000078093","abundance":48.8,"rank":1584,"name":"Homer1","annotation":"Homer protein homolog 1; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Differentially regulates the functions of the calcium activated channel ryanodine receptors RYR1 and RYR2. Isoform 1 decreases the acti [...] "},{"id":"ENSMUSP00000099945","abundance":48.8,"rank":1585,"name":"Plek","annotation":"Pleckstrin; Major protein kinase C substrate of platelets."},{"id":"ENSMUSP00000053818","abundance":48.8,"rank":1586,"name":"Gnat2","annotation":"Guanine nucleotide-binding protein G(t) subunit alpha-2; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP- phosphodiesterase; Belongs to the G-alpha family. G(i/o/t/z) subfamily."},{"id":"ENSMUSP00000090130","abundance":48.8,"rank":1587,"name":"Vps26a","annotation":"Vacuolar protein sorting-associated protein 26A; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3.The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] "},{"id":"ENSMUSP00000027384","abundance":48.6,"rank":1588,"name":"Atic","annotation":"Phosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis; Belongs to the PurH family."},{"id":"ENSMUSP00000125454","abundance":48.6,"rank":1589,"name":"Acat3","annotation":"Acetyl-Coenzyme A acetyltransferase 3; Belongs to the thiolase-like superfamily. Thiolase family."},{"id":"ENSMUSP00000088729","abundance":48.6,"rank":1590,"name":"Ddx3y","annotation":"ATP-dependent RNA helicase DDX3Y; Probable ATP-dependent RNA helicase. During immune response, may enhance IFNB1 expression via IRF3/IRF7 pathway."},{"id":"ENSMUSP00000069429","abundance":48.5,"rank":1591,"name":"Syp","annotation":"Synaptophysin; Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity; Belongs to the synaptophysin/synaptobrevin family."},{"id":"ENSMUSP00000118179","abundance":48.5,"rank":1592,"name":"Copa","annotation":"Coatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also inf [...] "},{"id":"ENSMUSP00000042852","abundance":48.4,"rank":1593,"name":"Tmem33","annotation":"Transmembrane protein 33; Acts as a regulator of the tubular endoplasmic reticulum (ER) network. Suppresses the RTN3/4-induced formation of the ER tubules. Positively regulates PERK-mediated and IRE1-mediated unfolded protein response signaling."},{"id":"ENSMUSP00000023062","abundance":48.4,"rank":1594,"name":"Tomm22","annotation":"Mitochondrial import receptor subunit TOM22 homolog; Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity); Belongs to the Tom22 family."},{"id":"ENSMUSP00000047218","abundance":48.4,"rank":1595,"name":"Grhpr","annotation":"Glyoxylate reductase/hydroxypyruvate reductase; Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D- glycerate to hydroxypyruvate (By similarity)."},{"id":"ENSMUSP00000092157","abundance":48.3,"rank":1596,"name":"Sec31a","annotation":"Protein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER) (By similarity). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). Belongs to the WD repeat SEC31 family."},{"id":"ENSMUSP00000112377","abundance":48.3,"rank":1597,"name":"Prxl2a","annotation":"Peroxiredoxin-like 2A; Involved in redox regulation of the cell (By similarity). Acts as an antioxidant (By similarity). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (By similarity). May affect bone resorption and help to maintain bone mass (By similarity). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway. Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily."},{"id":"ENSMUSP00000022341","abundance":48.2,"rank":1598,"name":"Rtraf","annotation":"RNA transcription, translation and transport factor protein; RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. Component of the tRNA-splicing ligase complex and is required for tRNA ligation. May be required for RNA transport."},{"id":"ENSMUSP00000027153","abundance":48.2,"rank":1599,"name":"Acadl","annotation":"Long-chain specific acyl-CoA dehydrogenase, mitochondrial; Long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenas [...] "},{"id":"ENSMUSP00000099881","abundance":48.2,"rank":1600,"name":"Gap43","annotation":"Neuromodulin; This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction."},{"id":"ENSMUSP00000032898","abundance":48.1,"rank":1601,"name":"Ipo5","annotation":"Importin-5; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis rel [...] "},{"id":"ENSMUSP00000033131","abundance":48.1,"rank":1602,"name":"Lamtor1","annotation":"Ragulator complex protein LAMTOR1; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulat [...] "},{"id":"ENSMUSP00000025696","abundance":48.1,"rank":1603,"name":"Ak3","annotation":"GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities."},{"id":"ENSMUSP00000075429","abundance":48.1,"rank":1604,"name":"Prcp","annotation":"Lysosomal Pro-X carboxypeptidase; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH (By similarity)."},{"id":"ENSMUSP00000007212","abundance":47.9,"rank":1605,"name":"Psmd2","annotation":"26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair."},{"id":"ENSMUSP00000107380","abundance":47.9,"rank":1606,"name":"Myl2","annotation":"Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] "},{"id":"ENSMUSP00000130941","abundance":47.8,"rank":1607,"name":"Mmut","annotation":"Methylmalonyl-CoA mutase, mitochondrial; Involved in the degradation of several amino acids, odd-chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle; Belongs to the methylmalonyl-CoA mutase family."},{"id":"ENSMUSP00000021329","abundance":47.7,"rank":1608,"name":"Gosr2","annotation":"Golgi SNAP receptor complex member 2; Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network."},{"id":"ENSMUSP00000105094","abundance":47.7,"rank":1609,"name":"Top1","annotation":"DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus remo [...] "},{"id":"ENSMUSP00000029877","abundance":47.7,"rank":1610,"name":"Decr1","annotation":"2,4-dienoyl-CoA reductase, mitochondrial; Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA."},{"id":"ENSMUSP00000026599","abundance":47.7,"rank":1611,"name":"Apool","annotation":"MICOS complex subunit Mic27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function."},{"id":"ENSMUSP00000090593","abundance":47.7,"rank":1612,"name":"Cluh","annotation":"Clustered mitochondria protein homolog; mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. Specifically binds mRNAs of nuclear- encoded mitochondrial proteins in the cytoplasm and regulates transport or translation of these transcripts close to mitochondria, playing a role in mitochondrial biogenesis."},{"id":"ENSMUSP00000139825","abundance":47.7,"rank":1613,"name":"Dhx9","annotation":"ATP-dependent RNA helicase A; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing. Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA a [...] "},{"id":"ENSMUSP00000133855","abundance":47.6,"rank":1614,"name":"Gps1","annotation":"COP9 signalosome complex subunit 1; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kina [...] "},{"id":"ENSMUSP00000113161","abundance":47.6,"rank":1615,"name":"Acyp1","annotation":"Acylphosphatase-1; Its physiological role is not yet clear; Belongs to the acylphosphatase family."},{"id":"ENSMUSP00000004057","abundance":47.6,"rank":1616,"name":"Fam162a","annotation":"Protein FAM162A; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly; Belongs to the UPF0389 family."},{"id":"ENSMUSP00000111942","abundance":47.6,"rank":1617,"name":"Arl1","annotation":"ADP-ribosylation factor-like protein 1; GTP-binding protein. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus (By similarity)."},{"id":"ENSMUSP00000038781","abundance":47.6,"rank":1618,"name":"Tbca","annotation":"Tubulin-specific chaperone A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway; Belongs to the TBCA family."},{"id":"ENSMUSP00000099561","abundance":47.5,"rank":1619,"name":"Mrto4","annotation":"mRNA turnover protein 4 homolog; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes."},{"id":"ENSMUSP00000016400","abundance":47.5,"rank":1620,"name":"Ctsz","annotation":"Cathepsin Z; Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (By similarity). Capable of producing kinin potentiating peptides (By similarity)."},{"id":"ENSMUSP00000125697","abundance":47.4,"rank":1621,"name":"Gng2","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000094863","abundance":47.3,"rank":1622,"name":"Gpx4","annotation":"Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins. Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species. The presence of selenocysteine (Se [...] "},{"id":"ENSMUSP00000033075","abundance":47.3,"rank":1623,"name":"Stx4a","annotation":"Syntaxin-4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family."},{"id":"ENSMUSP00000126825","abundance":47.3,"rank":1624,"name":"Eif5","annotation":"Eukaryotic translation initiation factor 5; Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]); Belongs to the eIF-2-beta/eIF-5 family."},{"id":"ENSMUSP00000107911","abundance":47.3,"rank":1625,"name":"Dao","annotation":"D-amino-acid oxidase; Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids."},{"id":"ENSMUSP00000030839","abundance":47.2,"rank":1626,"name":"Ctnnbip1","annotation":"Beta-catenin-interacting protein 1; Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway; Belongs to the CTNNBIP1 family."},{"id":"ENSMUSP00000157011","abundance":47.2,"rank":1627,"name":"Rab18","annotation":"Ras-related protein Rab-18; Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity)."},{"id":"ENSMUSP00000032825","abundance":47.1,"rank":1628,"name":"Mfge8","annotation":"Lactadherin; Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization."},{"id":"ENSMUSP00000060495","abundance":47.1,"rank":1629,"name":"Lect2","annotation":"Leukocyte cell-derived chemotaxin-2; Has a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation."},{"id":"ENSMUSP00000021335","abundance":47,"rank":1630,"name":"Scfd1","annotation":"Sec1 family domain-containing protein 1; Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity); Belongs to the STXBP/unc-18/SEC1 family."},{"id":"ENSMUSP00000090564","abundance":46.9,"rank":1631,"name":"Fbp1","annotation":"Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism  [...] "},{"id":"ENSMUSP00000126298","abundance":46.9,"rank":1632,"name":"Timm9","annotation":"Mitochondrial import inner membrane translocase subunit Tim9; Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family."},{"id":"ENSMUSP00000028817","abundance":46.9,"rank":1633,"name":"Pcna","annotation":"Proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'- phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA rep [...] "},{"id":"ENSMUSP00000037930","abundance":46.9,"rank":1634,"name":"Uggt1","annotation":"UDP-glucose:glycoprotein glucosyltransferase 1; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity)."},{"id":"ENSMUSP00000110087","abundance":46.8,"rank":1635,"name":"Pcnp","annotation":"PEST proteolytic signal-containing nuclear protein; May be involved in cell cycle regulation."},{"id":"ENSMUSP00000026552","abundance":46.7,"rank":1636,"name":"Cyp2e1","annotation":"Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics."},{"id":"ENSMUSP00000052020","abundance":46.7,"rank":1637,"name":"Flnb","annotation":"Filamin-B; Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton (By similarity). Belongs to the filamin family."},{"id":"ENSMUSP00000099394","abundance":46.5,"rank":1638,"name":"Aoc3","annotation":"Membrane primary amine oxidase; Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity)."},{"id":"ENSMUSP00000126828","abundance":46.4,"rank":1639,"name":"Dnajb11","annotation":"DnaJ homolog subfamily B member 11; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1."},{"id":"ENSMUSP00000005218","abundance":46.3,"rank":1640,"name":"Cd44","annotation":"CD44 antigen; Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its c [...] "},{"id":"ENSMUSP00000001384","abundance":46.3,"rank":1641,"name":"Cnn1","annotation":"Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity."},{"id":"ENSMUSP00000107060","abundance":46.2,"rank":1642,"name":"Creg1","annotation":"Protein CREG1; May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R (By similarity)."},{"id":"ENSMUSP00000095507","abundance":46.2,"rank":1643,"name":"Macf1","annotation":"Microtubule-actin cross-linking factor 1; [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (By similarity). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin- regulated ATPase activity and is essential for controlling focal adhesions  [...] "},{"id":"ENSMUSP00000068086","abundance":46.2,"rank":1644,"name":"Ldhd","annotation":"Probable D-lactate dehydrogenase, mitochondrial; Involved in D-lactate, but not L-lactate catabolic process. Belongs to the FAD-binding oxidoreductase/transferase type 4 family."},{"id":"ENSMUSP00000080991","abundance":46.1,"rank":1645,"name":"mt-Nd1","annotation":"NADH-ubiquinone oxidoreductase chain 1; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000033184","abundance":46.1,"rank":1646,"name":"Tpp1","annotation":"Tripeptidyl-peptidase 1; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity)."},{"id":"ENSMUSP00000125752","abundance":46.1,"rank":1647,"name":"Pdcd10","annotation":"Programmed cell death protein 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity); Belongs to the PDCD10 family."},{"id":"ENSMUSP00000121883","abundance":46.1,"rank":1648,"name":"Gm16286","annotation":"Predicted gene 16286."},{"id":"ENSMUSP00000133515","abundance":46,"rank":1649,"name":"Ube2g2","annotation":"Ubiquitin-conjugating enzyme E2 G2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD); Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000016452","abundance":46,"rank":1650,"name":"Ube2a","annotation":"Ubiquitin-conjugating enzyme E2 A; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Requi [...] "},{"id":"ENSMUSP00000101809","abundance":45.8,"rank":1651,"name":"Hgs","annotation":"Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] "},{"id":"ENSMUSP00000021864","abundance":45.8,"rank":1652,"name":"Ssr1","annotation":"Translocon-associated protein subunit alpha; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins."},{"id":"ENSMUSP00000027863","abundance":45.8,"rank":1653,"name":"Atp1b1","annotation":"Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane."},{"id":"ENSMUSP00000054370","abundance":45.8,"rank":1654,"name":"Acad8","annotation":"Isobutyryl-CoA dehydrogenase, mitochondrial; Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA."},{"id":"ENSMUSP00000038841","abundance":45.8,"rank":1655,"name":"Rap2b","annotation":"Ras-related protein Rap-2b; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells."},{"id":"ENSMUSP00000101588","abundance":45.8,"rank":1656,"name":"Lsp1","annotation":"Lymphocyte-specific protein 1; May play a role in mediating neutrophil activation and chemotaxis."},{"id":"ENSMUSP00000047665","abundance":45.6,"rank":1657,"name":"Adk","annotation":"Adenosine kinase; ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides; Belongs to the carbohydrate kinase PfkB family."},{"id":"ENSMUSP00000020702","abundance":45.6,"rank":1658,"name":"Igfbp3","annotation":"Insulin-like growth factor-binding protein 3; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R."},{"id":"ENSMUSP00000077757","abundance":45.5,"rank":1659,"name":"Bak1","annotation":"Bcl-2 homologous antagonist/killer; In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2."},{"id":"ENSMUSP00000027173","abundance":45.5,"rank":1660,"name":"Wdr12","annotation":"Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome."},{"id":"ENSMUSP00000034400","abundance":45.5,"rank":1661,"name":"Cyb5b","annotation":"Cytochrome b5 type B; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases."},{"id":"ENSMUSP00000030134","abundance":45.5,"rank":1662,"name":"Rad23b","annotation":"UV excision repair protein RAD23 homolog B; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.  The XPC complex is proposed to represent the first factor bound at the sites of DNA damage  [...] "},{"id":"ENSMUSP00000121977","abundance":45.4,"rank":1663,"name":"Vamp4","annotation":"Vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity); Belongs to the synaptobrevin family."},{"id":"ENSMUSP00000113637","abundance":45.4,"rank":1664,"name":"Nfu1","annotation":"NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; Iron-sulfur cluster scaffold protein which can assemble [4Fe- 4S] clusters and deliver them to target proteins."},{"id":"ENSMUSP00000055637","abundance":45.3,"rank":1665,"name":"Marcksl1","annotation":"MARCKS-related protein; Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems (Probable)."},{"id":"ENSMUSP00000122471","abundance":45.3,"rank":1666,"name":"Ube2k","annotation":"Ubiquitin-conjugating enzyme E2 K; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam [...] "},{"id":"ENSMUSP00000034000","abundance":45.3,"rank":1667,"name":"Asah1","annotation":"Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By simil [...] "},{"id":"ENSMUSP00000030665","abundance":45.2,"rank":1668,"name":"Nudc","annotation":"Nuclear migration protein nudC; Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis (By similarity)."},{"id":"ENSMUSP00000110398","abundance":45.2,"rank":1669,"name":"Gsk3b","annotation":"Glycogen synthase kinase-3 beta; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glyc [...] "},{"id":"ENSMUSP00000028509","abundance":45.2,"rank":1670,"name":"Gorasp2","annotation":"Golgi reassembly-stacking protein 2; Plays a role in assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA (By similarity). Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells. Mediates ER stress-induced unconventional (ER/Gol [...] "},{"id":"ENSMUSP00000001416","abundance":45.1,"rank":1671,"name":"Hars","annotation":"Histidine--tRNA ligase, cytoplasmic; Catalyzes the ATP-dependent ligation of histidine to the 3'- end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance. Belongs to the class-II aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000023467","abundance":45.1,"rank":1672,"name":"Pak2","annotation":"Serine/threonine-protein kinase PAK 2; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream targ [...] "},{"id":"ENSMUSP00000103028","abundance":45.1,"rank":1673,"name":"Adar","annotation":"Double-stranded RNA-specific adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structur [...] "},{"id":"ENSMUSP00000032143","abundance":45,"rank":1674,"name":"Rpn1","annotation":"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] "},{"id":"ENSMUSP00000026222","abundance":45,"rank":1675,"name":"Ndufb8","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000022380","abundance":45,"rank":1676,"name":"Psmc6","annotation":"26S proteasome regulatory subunit 10B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC6 belongs to the heterohexameric ring of AAA (ATPases associated wi [...] "},{"id":"ENSMUSP00000003622","abundance":45,"rank":1677,"name":"Slc25a1","annotation":"Tricarboxylate transport protein, mitochondrial; Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000098648","abundance":44.9,"rank":1678,"name":"Srp72","annotation":"Signal recognition particle subunit SRP72; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane; Belongs to the SRP72 family."},{"id":"ENSMUSP00000154171","abundance":44.9,"rank":1679,"name":"Gm49342","annotation":"Predicted gene, 49342."},{"id":"ENSMUSP00000097061","abundance":44.8,"rank":1680,"name":"Gng7","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in t [...] "},{"id":"ENSMUSP00000029521","abundance":44.8,"rank":1681,"name":"Crct1","annotation":"Cysteine-rich C-terminal 1."},{"id":"ENSMUSP00000066715","abundance":44.8,"rank":1682,"name":"Marc2","annotation":"Mitochondrial amidoxime reducing component 2; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] "},{"id":"ENSMUSP00000027824","abundance":44.8,"rank":1683,"name":"Apcs","annotation":"Serum amyloid P-component; Belongs to the pentraxin family."},{"id":"ENSMUSP00000007130","abundance":44.8,"rank":1684,"name":"Ctnnb1","annotation":"Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an  [...] "},{"id":"ENSMUSP00000112221","abundance":44.7,"rank":1685,"name":"Nck1","annotation":"Cytoplasmic protein NCK1; Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA (By similarity)."},{"id":"ENSMUSP00000030726","abundance":44.7,"rank":1686,"name":"Rcc1","annotation":"Regulator of chromosome condensation; Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP, and thereby plays an important role in RAN-mediated functions in nuclear import and mitosis. Contributes to the generation of high levels of chromosome-associated, GTP-bound RAN, which is important for mitotic spindle assembly and normal progress through mitosis. Via its role in maintaining high levels of GTP-bound RAN in the nucleus, contributes to the release of cargo proteins from importins after nuclear import. Involved in the regulation of onset of chromoso [...] "},{"id":"ENSMUSP00000027503","abundance":44.6,"rank":1687,"name":"Dtymk","annotation":"Thymidylate kinase; Catalyzes the conversion of dTMP to dTDP; Belongs to the thymidylate kinase family."},{"id":"ENSMUSP00000093473","abundance":44.6,"rank":1688,"name":"Spin1","annotation":"Spindlin-1; Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (By similarity). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Inv [...] "},{"id":"ENSMUSP00000124579","abundance":44.6,"rank":1689,"name":"Asl","annotation":"Argininosuccinate lyase; Belongs to the lyase 1 family. Argininosuccinate lyase subfamily."},{"id":"ENSMUSP00000077446","abundance":44.6,"rank":1690,"name":"Mff","annotation":"Mitochondrial fission factor; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. Belongs to the Tango11 family."},{"id":"ENSMUSP00000103209","abundance":44.4,"rank":1691,"name":"Cisd3","annotation":"CDGSH iron-sulfur domain-containing protein 3, mitochondrial; Can transfer its iron-sulfur clusters to the apoferrodoxins FDX1 and FDX2. Contributes to mitochondrial iron homeostasis and in maintaining normal levels of free iron and reactive oxygen species, and thereby contributes to normal mitochondrial function. Belongs to the CISD protein family."},{"id":"ENSMUSP00000057336","abundance":44.4,"rank":1692,"name":"Naa11","annotation":"N-alpha-acetyltransferase 11; Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex."},{"id":"ENSMUSP00000042155","abundance":44.4,"rank":1693,"name":"Oxsr1","annotation":"Serine/threonine-protein kinase OSR1; Phosphorylates RELL1, RELL2, RELT and PAK1. Phosphorylates PLSCR1 in the presence of RELT."},{"id":"ENSMUSP00000026839","abundance":44.4,"rank":1694,"name":"Prps2","annotation":"Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family."},{"id":"ENSMUSP00000002289","abundance":44.4,"rank":1695,"name":"Uchl3","annotation":"Ubiquitin carboxyl-terminal hydrolase isozyme L3; Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3'', and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO [...] "},{"id":"ENSMUSP00000117947","abundance":44.3,"rank":1696,"name":"Snrpa1","annotation":"U2 small nuclear ribonucleoprotein A; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA."},{"id":"ENSMUSP00000078138","abundance":44.3,"rank":1697,"name":"H2-Q2","annotation":"Histocompatibility 2, Q region locus 2; Belongs to the MHC class I family."},{"id":"ENSMUSP00000113343","abundance":44.2,"rank":1698,"name":"Mrps10","annotation":"28S ribosomal protein S10, mitochondrial; Belongs to the universal ribosomal protein uS10 family."},{"id":"ENSMUSP00000115704","abundance":44.2,"rank":1699,"name":"Ptgr2","annotation":"Prostaglandin reductase 2; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation."},{"id":"ENSMUSP00000071618","abundance":44.1,"rank":1700,"name":"Erlin1","annotation":"Erlin-1; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (By similarity)."},{"id":"ENSMUSP00000102138","abundance":44.1,"rank":1701,"name":"Acsm3","annotation":"Acyl-coenzyme A synthetase ACSM3, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids with a preference for isobutyrate among fatty acids with 2-6 carbon atoms. Belongs to the ATP-dependent AMP-binding enzyme family."},{"id":"ENSMUSP00000038755","abundance":44.1,"rank":1702,"name":"Abhd14b","annotation":"Protein ABHD14B; Has hydrolase activity towards p-nitrophenyl butyrate (in vitro). May activate transcription (By similarity)."},{"id":"ENSMUSP00000108148","abundance":44.1,"rank":1703,"name":"Sms","annotation":"Spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) (By similarity). Required for normal viability, growth and fertility; Belongs to the spermidine/spermine synthase family."},{"id":"ENSMUSP00000023873","abundance":44,"rank":1704,"name":"Prmt5","annotation":"Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H and may regulate its transcriptional elongation properties. Mono- and dimethylates arginine residues of myelin b [...] "},{"id":"ENSMUSP00000007340","abundance":44,"rank":1705,"name":"Atp12a","annotation":"Potassium-transporting ATPase alpha chain 2; Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues."},{"id":"ENSMUSP00000077781","abundance":44,"rank":1706,"name":"Enah","annotation":"Protein enabled homolog; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation."},{"id":"ENSMUSP00000023486","abundance":43.8,"rank":1707,"name":"Tfrc","annotation":"Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Upon stimulation, positively regulates T and B cell proliferation through iron uptake ; Belongs to t [...] "},{"id":"ENSMUSP00000033775","abundance":43.8,"rank":1708,"name":"Mpp1","annotation":"55 kDa erythrocyte membrane protein; Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity. Belongs to the MAGUK family."},{"id":"ENSMUSP00000114069","abundance":43.8,"rank":1709,"name":"Fkbp8","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP8; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development."},{"id":"ENSMUSP00000133245","abundance":43.7,"rank":1710,"name":"Ddx46","annotation":"Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during A complex formation."},{"id":"ENSMUSP00000070310","abundance":43.7,"rank":1711,"name":"Meig1","annotation":"Meiosis-expressed gene 1 protein; Essential for spermiogenesis; Belongs to the MEIG1 family."},{"id":"ENSMUSP00000098295","abundance":43.7,"rank":1712,"name":"Psmd9","annotation":"26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). During the base subcomplex assembly is part of an intermediate PSMD9:PSMC6:PSMC3 module, also known as modulator trimer complex; PSMD9 is released during the further base assembly process (By similarity); Belongs to the proteasome subunit p27 family."},{"id":"ENSMUSP00000053943","abundance":43.7,"rank":1713,"name":"Basp1","annotation":"Brain acid soluble protein 1."},{"id":"ENSMUSP00000033049","abundance":43.7,"rank":1714,"name":"Cox6a2","annotation":"Cytochrome c oxidase subunit 6A2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembran [...] "},{"id":"ENSMUSP00000025083","abundance":43.6,"rank":1715,"name":"Kif5b","annotation":"Kinesin-1 heavy chain; Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. May be involved in the mechanisms of growth arrest induced by exposure to DNA-damaging drugs or by cellular senescence. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2- dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes. Required for anterograde axona [...] "},{"id":"ENSMUSP00000000365","abundance":43.6,"rank":1716,"name":"Mcts1","annotation":"Malignant T-cell-amplified sequence 1; Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated diss [...] "},{"id":"ENSMUSP00000033342","abundance":43.6,"rank":1717,"name":"Eif3f","annotation":"Eukaryotic translation initiation factor 3 subunit F; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] "},{"id":"ENSMUSP00000069956","abundance":43.5,"rank":1718,"name":"Tmod2","annotation":"Tropomodulin-2; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)."},{"id":"ENSMUSP00000033761","abundance":43.5,"rank":1719,"name":"Hcfc1","annotation":"HCF C-terminal chain 1; Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity). Coactivator for EGR2 and GABP2 (By similarity). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal hist [...] "},{"id":"ENSMUSP00000152229","abundance":43.5,"rank":1720,"name":"Pitrm1","annotation":"Presequence protease, mitochondrial; Metalloendopeptidase of the mitochondrial matrix that functions in peptide cleavage and degradation rather than in protein processing. Has an ATP-independent activity. Specifically cleaves peptides in the range of 5 to 65 residues. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Degrades the transit peptides of mitochondrial proteins after their cleavage. Also degrades other unstructured peptides. It is also able to degrade amyloid-beta protein 40, one of the peptides produ [...] "},{"id":"ENSMUSP00000022946","abundance":43.5,"rank":1721,"name":"Rida","annotation":"2-iminobutanoate/2-iminopropanoate deaminase; Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'- phosphate-dependent dehydratases including L-threonine dehydratase."},{"id":"ENSMUSP00000133063","abundance":43.5,"rank":1722,"name":"Cntn1","annotation":"Contactin-1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] "},{"id":"ENSMUSP00000091061","abundance":43.4,"rank":1723,"name":"Nefh","annotation":"Neurofilament heavy polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins."},{"id":"ENSMUSP00000015197","abundance":43.4,"rank":1724,"name":"Gata2","annotation":"Endothelial transcription factor GATA-2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'- AGATAG-3'."},{"id":"ENSMUSP00000131728","abundance":43.4,"rank":1725,"name":"Gm20498","annotation":"Predicted gene 20498."},{"id":"ENSMUSP00000028807","abundance":43.4,"rank":1726,"name":"Ivd","annotation":"Isovaleryl-CoA dehydrogenase, mitochondrial; Belongs to the acyl-CoA dehydrogenase family."},{"id":"ENSMUSP00000071214","abundance":43.4,"rank":1727,"name":"Eif2s1","annotation":"Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed  [...] "},{"id":"ENSMUSP00000101620","abundance":43.3,"rank":1728,"name":"Tinagl1","annotation":"Tubulointerstitial nephritis antigen-like; May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein."},{"id":"ENSMUSP00000028938","abundance":43.3,"rank":1729,"name":"Cst3","annotation":"Cystatin-C; As an inhibitor of cysteine proteinases, this protein is thought to serve an important physiological role as a local regulator of this enzyme activity; Belongs to the cystatin family."},{"id":"ENSMUSP00000028083","abundance":43.3,"rank":1730,"name":"Psmb7","annotation":"Proteasome subunit beta type-7; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] "},{"id":"ENSMUSP00000020440","abundance":43.3,"rank":1731,"name":"Timm13","annotation":"Mitochondrial import inner membrane translocase subunit Tim13; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8- TIMM13 complex mediates the import of proteins  [...] "},{"id":"ENSMUSP00000116028","abundance":43.2,"rank":1732,"name":"Myo5a","annotation":"Unconventional myosin-Va; Processive actin-based motor that can move in large steps approximating the 36-nm pseudo-repeat of the actin filament. Involved in melanosome transport. Also mediates the transport of vesicles to the plasma membrane. May also be required for some polarization process involved in dendrite formation; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000056622","abundance":43.1,"rank":1733,"name":"Krt34","annotation":"Keratin, type I cuticular Ha4; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000081574","abundance":43.1,"rank":1734,"name":"Slc31a1","annotation":"High affinity copper uptake protein 1; High-affinity, saturable copper transporter involved in dietary copper uptake."},{"id":"ENSMUSP00000106926","abundance":43.1,"rank":1735,"name":"Nit1","annotation":"Deaminated glutathione amidase; Catalyzes the hydrolysis of the amide bond in N-(4- oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Possesses amidase activity toward deaminated ophthalmate in vitro. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor [...] "},{"id":"ENSMUSP00000014445","abundance":43.1,"rank":1736,"name":"Pam16","annotation":"Mitochondrial import inner membrane translocase subunit TIM16; Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity (By similarity)."},{"id":"ENSMUSP00000137140","abundance":43.1,"rank":1737,"name":"Gm9803","annotation":"Predicted gene 9803."},{"id":"ENSMUSP00000080995","abundance":43.1,"rank":1738,"name":"mt-Atp8","annotation":"ATP synthase protein 8; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] "},{"id":"ENSMUSP00000029708","abundance":43,"rank":1739,"name":"Naxe","annotation":"NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX."},{"id":"ENSMUSP00000027853","abundance":43,"rank":1740,"name":"Mpc2","annotation":"Mitochondrial pyruvate carrier 2; Mediates the uptake of pyruvate into mitochondria."},{"id":"ENSMUSP00000063707","abundance":43,"rank":1741,"name":"C1ra","annotation":"Complement C1r-A subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000010795","abundance":42.9,"rank":1742,"name":"Acaa1b","annotation":"3-ketoacyl-CoA thiolase B, peroxisomal."},{"id":"ENSMUSP00000042602","abundance":42.9,"rank":1743,"name":"Apex1","annotation":"DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break w [...] "},{"id":"ENSMUSP00000107727","abundance":42.7,"rank":1744,"name":"Pbrm1","annotation":"Protein polybromo-1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). Acts as a negative regulator of cell proliferation."},{"id":"ENSMUSP00000028624","abundance":42.7,"rank":1745,"name":"Gatm","annotation":"Glycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development."},{"id":"ENSMUSP00000099944","abundance":42.7,"rank":1746,"name":"Ppp3r1","annotation":"Calcineurin subunit B type 1; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity."},{"id":"ENSMUSP00000065002","abundance":42.6,"rank":1747,"name":"Purg","annotation":"Purine-rich element-binding protein gamma."},{"id":"ENSMUSP00000011029","abundance":42.6,"rank":1748,"name":"Dnajc19","annotation":"Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity); Belongs to the TIM14 family."},{"id":"ENSMUSP00000138965","abundance":42.6,"rank":1749,"name":"Gm17190","annotation":"Predicted gene 17190."},{"id":"ENSMUSP00000124317","abundance":42.6,"rank":1750,"name":"Tbp","annotation":"TATA-box-binding protein; General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase  [...] "},{"id":"ENSMUSP00000022082","abundance":42.5,"rank":1751,"name":"Glrx","annotation":"Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family."},{"id":"ENSMUSP00000038839","abundance":42.5,"rank":1752,"name":"Eif3l","annotation":"Eukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] "},{"id":"ENSMUSP00000064204","abundance":42.5,"rank":1753,"name":"Lypla2","annotation":"Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity. Belongs to the AB hydrolase superfamily. AB hydrolase 2 family."},{"id":"ENSMUSP00000022507","abundance":42.4,"rank":1754,"name":"Pspc1","annotation":"Paraspeckle component 1; Together with NONO, required for the formation of nuclear paraspeckles. Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP- RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent inn [...] "},{"id":"ENSMUSP00000032844","abundance":42.4,"rank":1755,"name":"Tmem126a","annotation":"Transmembrane protein 126A; Belongs to the TMEM126 family."},{"id":"ENSMUSP00000038048","abundance":42.3,"rank":1756,"name":"Lrg1","annotation":"Leucine-rich alpha-2-glycoprotein 1."},{"id":"ENSMUSP00000102790","abundance":42.3,"rank":1757,"name":"Dusp3","annotation":"Dual specificity protein phosphatase 3; Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2 (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000051643","abundance":42.3,"rank":1758,"name":"Dnajc11","annotation":"DnaJ homolog subfamily C member 11; Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex. Belongs to the DNAJC11 family."},{"id":"ENSMUSP00000031447","abundance":42.2,"rank":1759,"name":"Anxa3","annotation":"Annexin A3; Inhibitor of phospholipase A2, also possesses anti-coagulant properties; Belongs to the annexin family."},{"id":"ENSMUSP00000030501","abundance":42.1,"rank":1760,"name":"Ebna1bp2","annotation":"Probable rRNA-processing protein EBP2; Required for the processing of the 27S pre-rRNA."},{"id":"ENSMUSP00000051935","abundance":42.1,"rank":1761,"name":"Bzw1","annotation":"Basic leucine zipper and W2 domain-containing protein 1; Enhances histone H4 gene transcription but does not seem to bind DNA directly; Belongs to the BZW family."},{"id":"ENSMUSP00000095690","abundance":42,"rank":1762,"name":"Acsm2","annotation":"Acyl-coenzyme A synthetase ACSM2, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (By similarity)."},{"id":"ENSMUSP00000128483","abundance":42,"rank":1763,"name":"Anp32e","annotation":"Acidic leucine-rich nuclear phosphoprotein 32 family member E; Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar [...] "},{"id":"ENSMUSP00000022765","abundance":42,"rank":1764,"name":"Rab2b","annotation":"Ras-related protein Rab-2B; Required for protein transport from the endoplasmic reticulum to the Golgi complex; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000035658","abundance":42,"rank":1765,"name":"Qsox1","annotation":"Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration."},{"id":"ENSMUSP00000085712","abundance":41.9,"rank":1766,"name":"Srgap3","annotation":"SLIT-ROBO Rho GTPase-activating protein 3; GTPase-activating protein for RAC1 and perhaps CDC42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons (By similarity)."},{"id":"ENSMUSP00000007482","abundance":41.9,"rank":1767,"name":"Mrpl49","annotation":"39S ribosomal protein L49, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL49 family."},{"id":"ENSMUSP00000030455","abundance":41.9,"rank":1768,"name":"Akr1a1","annotation":"Aldo-keto reductase family 1 member A1; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (By similarity). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone. Functions as a detoxifiying enzyme b [...] "},{"id":"ENSMUSP00000095247","abundance":41.9,"rank":1769,"name":"Cops9","annotation":"COP9 signalosome complex subunit 9; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- [...] "},{"id":"ENSMUSP00000030078","abundance":41.9,"rank":1770,"name":"Hsdl2","annotation":"Hydroxysteroid dehydrogenase-like protein 2; Has apparently no steroid dehydrogenase activity. Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000032992","abundance":41.9,"rank":1771,"name":"Eif3c","annotation":"Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] "},{"id":"ENSMUSP00000029845","abundance":41.8,"rank":1772,"name":"Ddah1","annotation":"N(G),N(G)-dimethylarginine dimethylaminohydrolase 1; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. Belongs to the DDAH family."},{"id":"ENSMUSP00000105147","abundance":41.8,"rank":1773,"name":"Polr2c","annotation":"DNA-directed RNA polymerase II subunit RPB3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity)."},{"id":"ENSMUSP00000020630","abundance":41.7,"rank":1774,"name":"Hspa4","annotation":"Heat shock 70 kDa protein 4; Belongs to the heat shock protein 70 family."},{"id":"ENSMUSP00000062622","abundance":41.7,"rank":1775,"name":"Dhx30","annotation":"ATP-dependent RNA helicase DHX30; RNA-dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit (By similarity). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (By similarity). Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD ; Belongs to the DEAD box helicase family. DEAH subfamily."},{"id":"ENSMUSP00000001834","abundance":41.7,"rank":1776,"name":"Rtcb","annotation":"RNA-splicing ligase RtcB homolog; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity). Essential during post-implantation development of embryos."},{"id":"ENSMUSP00000085244","abundance":41.7,"rank":1777,"name":"Tpp2","annotation":"Tripeptidyl-peptidase 2; Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter is inhibited (By similarity). Stimulates adipogenesis."},{"id":"ENSMUSP00000017188","abundance":41.6,"rank":1778,"name":"Serpinb6a","annotation":"Serpin B6; Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood."},{"id":"ENSMUSP00000022639","abundance":41.6,"rank":1779,"name":"Nefl","annotation":"Neurofilament light polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber."},{"id":"ENSMUSP00000048770","abundance":41.6,"rank":1780,"name":"Atp6v1g1","annotation":"V-type proton ATPase subunit G 1; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity)."},{"id":"ENSMUSP00000110987","abundance":41.6,"rank":1781,"name":"Prkcsh","annotation":"Glucosidase 2 subunit beta; Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia."},{"id":"ENSMUSP00000105657","abundance":41.5,"rank":1782,"name":"Snx5","annotation":"Sorting nexin-5; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol lipids. Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-me [...] "},{"id":"ENSMUSP00000031910","abundance":41.5,"rank":1783,"name":"Prss1","annotation":"Protease, serine, 1 (Trypsin 1); Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000112442","abundance":41.5,"rank":1784,"name":"Palld","annotation":"Palladin; Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have  [...] "},{"id":"ENSMUSP00000068282","abundance":41.5,"rank":1785,"name":"Ugt2b5","annotation":"UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds."},{"id":"ENSMUSP00000109288","abundance":41.5,"rank":1786,"name":"Gfpt1","annotation":"Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1."},{"id":"ENSMUSP00000138691","abundance":41.4,"rank":1787,"name":"Rsrc2","annotation":"Arginine/serine-rich coiled-coil protein 2; Belongs to the RSRC2 family."},{"id":"ENSMUSP00000004786","abundance":41.3,"rank":1788,"name":"Polr2e","annotation":"DNA-directed RNA polymerases I, II, and III subunit RPABC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the [...] "},{"id":"ENSMUSP00000117816","abundance":41.3,"rank":1789,"name":"Slmap","annotation":"Sarcolemmal membrane-associated protein; May play a role during myoblast fusion."},{"id":"ENSMUSP00000072803","abundance":41.3,"rank":1790,"name":"Ugt1a1","annotation":"UDP-glucuronosyltransferase 1-1; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds."},{"id":"ENSMUSP00000072145","abundance":41.2,"rank":1791,"name":"Vsnl1","annotation":"Visinin-like protein 1; Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner; Belongs to the recoverin family."},{"id":"ENSMUSP00000074783","abundance":41.2,"rank":1792,"name":"Ttr","annotation":"Transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain."},{"id":"ENSMUSP00000128921","abundance":41.2,"rank":1793,"name":"Arpp19","annotation":"cAMP-regulated phosphoprotein 19; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF- regulatory region of its mRNA (By similarity); Belongs to the endosulfine family."},{"id":"ENSMUSP00000102296","abundance":41.2,"rank":1794,"name":"Gstm6","annotation":"Glutathione S-transferase Mu 6; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles."},{"id":"ENSMUSP00000056433","abundance":41.1,"rank":1795,"name":"Rap2a","annotation":"Ras-related protein Rap-2a; Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading; Belongs to the small GTPase superfamily. Ras family."},{"id":"ENSMUSP00000033873","abundance":41.1,"rank":1796,"name":"Erlin2","annotation":"Erlin-2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5- trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol- accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity). Belongs to the band 7/mec-2 family."},{"id":"ENSMUSP00000103904","abundance":41,"rank":1797,"name":"Lgals9","annotation":"Galectin-9; Binds galactosides (By similarity). Has high affinity for the Forssman pentasaccharide (By similarity). Ligand for HAVCR2/TIM3 (By similarity). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (By similarity). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth. Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox stat [...] "},{"id":"ENSMUSP00000029135","abundance":41,"rank":1798,"name":"Acss2","annotation":"Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family."},{"id":"ENSMUSP00000033229","abundance":40.9,"rank":1799,"name":"Hbb-y","annotation":"Hemoglobin subunit epsilon-Y2; Hemoglobin epsilon chain is a beta-type chain found in early embryos; Belongs to the globin family."},{"id":"ENSMUSP00000001713","abundance":40.9,"rank":1800,"name":"Gstt1","annotation":"Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity."},{"id":"ENSMUSP00000131386","abundance":40.9,"rank":1801,"name":"Ssr4","annotation":"Translocon-associated protein subunit delta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins."},{"id":"ENSMUSP00000018711","abundance":40.8,"rank":1802,"name":"Gabarap","annotation":"Gamma-aminobutyric acid receptor-associated protein; Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity); Belongs to the ATG8 family."},{"id":"ENSMUSP00000038838","abundance":40.8,"rank":1803,"name":"Lyn","annotation":"Tyrosine-protein kinase Lyn; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-c [...] "},{"id":"ENSMUSP00000023432","abundance":40.7,"rank":1804,"name":"Nit2","annotation":"Omega-amidase NIT2; Possesses omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively. Can hydrolyze glutaramate, succinate and gamma- monomethyl-alpha-ketoglutarate in vitro."},{"id":"ENSMUSP00000021603","abundance":40.6,"rank":1805,"name":"Fbln5","annotation":"Fibulin-5; Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (By similarity). Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN (By similarity)."},{"id":"ENSMUSP00000002663","abundance":40.6,"rank":1806,"name":"Pon1","annotation":"Serum paraoxonase/arylesterase 1; Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification. Belongs to the paraoxonase family."},{"id":"ENSMUSP00000080993","abundance":40.6,"rank":1807,"name":"mt-Co1","annotation":"Cytochrome c oxidase subunit 1; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] "},{"id":"ENSMUSP00000026565","abundance":40.5,"rank":1808,"name":"Ifitm3","annotation":"Interferon-induced transmembrane protein 3; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV) and human immunodeficiency virus type 1 (HIV-1). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry a [...] "},{"id":"ENSMUSP00000057669","abundance":40.5,"rank":1809,"name":"Rhot1","annotation":"Mitochondrial Rho GTPase 1; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity)."},{"id":"ENSMUSP00000106709","abundance":40.5,"rank":1810,"name":"Ap1s1","annotation":"AP-1 complex subunit sigma-1A; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules."},{"id":"ENSMUSP00000131735","abundance":40.4,"rank":1811,"name":"Eci2","annotation":"Enoyl-CoA delta isomerase 2, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species. Has a preference for 3-trans substrates (By similarity)."},{"id":"ENSMUSP00000106133","abundance":40.4,"rank":1812,"name":"Sqor","annotation":"Sulfide:quinone oxidoreductase, mitochondrial; Catalyzes the oxidation of hydrogen sulfide with the help of a quinone, such as ubiquinone, giving rise to thiosulfate and ultimately to sulfane (molecular sulfur) atoms. Requires an additional electron acceptor; can use sulfite, sulfide or cyanide (in vitro). Belongs to the SQRD family."},{"id":"ENSMUSP00000136493","abundance":40.4,"rank":1813,"name":"Tomm20","annotation":"Mitochondrial import receptor subunit TOM20 homolog; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases."},{"id":"ENSMUSP00000002790","abundance":40.4,"rank":1814,"name":"Cse1l","annotation":"Exportin-2; Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause releas [...] "},{"id":"ENSMUSP00000025027","abundance":40.4,"rank":1815,"name":"Cuta","annotation":"Protein CutA."},{"id":"ENSMUSP00000101486","abundance":40.4,"rank":1816,"name":"Ncmap","annotation":"Noncompact myelin-associated protein; Plays a role in myelin formation."},{"id":"ENSMUSP00000153410","abundance":40.4,"rank":1817,"name":"Aldh1a1","annotation":"Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity)."},{"id":"ENSMUSP00000027377","abundance":40.3,"rank":1818,"name":"Igfbp5","annotation":"Insulin-like growth factor-binding protein 5; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors."},{"id":"ENSMUSP00000041260","abundance":40.3,"rank":1819,"name":"Aldh1b1","annotation":"Aldehyde dehydrogenase X, mitochondrial; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity)."},{"id":"ENSMUSP00000156511","abundance":40.3,"rank":1820,"name":"Qk","annotation":"Protein quaking; RNA-binding protein that plays a central role in myelinization. Also required for visceral endoderm function and blood vessel development. Binds to the 5'-NACUAAY-N(1,20)- UAAY-3' RNA core sequence. Acts by regulating pre- mRNA splicing, mRNA export, mRNA stability and protein translation, as well as cellular processes including apoptosis, cell cycle, glial cell fate and development. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of [...] "},{"id":"ENSMUSP00000027472","abundance":40.3,"rank":1821,"name":"Efhd1","annotation":"EF-hand domain-containing protein D1; Acts as a calcium sensor for mitochondrial flash (mitoflash) activation, an event characterized by stochastic bursts of superoxide production (By similarity). May play a role in neuronal differentiation."},{"id":"ENSMUSP00000091476","abundance":40.3,"rank":1822,"name":"Hoxb3","annotation":"Homeobox protein Hox-B3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family."},{"id":"ENSMUSP00000113510","abundance":40.3,"rank":1823,"name":"Art3","annotation":"Ecto-ADP-ribosyltransferase 3."},{"id":"ENSMUSP00000071163","abundance":40.3,"rank":1824,"name":"Rcc2","annotation":"Protein RCC2; Multifunctional protein that may effect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 b [...] "},{"id":"ENSMUSP00000046530","abundance":40.2,"rank":1825,"name":"Itih2","annotation":"Inter-alpha-trypsin inhibitor heavy chain H2; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes; Belongs to the ITIH family."},{"id":"ENSMUSP00000001479","abundance":40.2,"rank":1826,"name":"Kpnb1","annotation":"Importin subunit beta-1; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic  [...] "},{"id":"ENSMUSP00000000925","abundance":40.2,"rank":1827,"name":"Smarcb1","annotation":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Core component of the BAF (SWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structu [...] "},{"id":"ENSMUSP00000038069","abundance":40.1,"rank":1828,"name":"H2-Ke6","annotation":"Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH- dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD."},{"id":"ENSMUSP00000067708","abundance":40.1,"rank":1829,"name":"Actn2","annotation":"Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity)."},{"id":"ENSMUSP00000007980","abundance":40,"rank":1830,"name":"Hnrnpa0","annotation":"Heterogeneous nuclear ribonucleoprotein A0; mRNA-binding component of ribonucleosomes. Specifically binds AU-rich element (ARE)-containing mRNAs. Involved in post- transcriptional regulation of cytokines mRNAs."},{"id":"ENSMUSP00000112935","abundance":40,"rank":1831,"name":"Golga7","annotation":"Golgin subfamily A member 7; May be involved in protein transport from Golgi to cell surface. The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS (By similarity)."},{"id":"ENSMUSP00000021607","abundance":40,"rank":1832,"name":"Lgmn","annotation":"Legumain; Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation."},{"id":"ENSMUSP00000026937","abundance":39.9,"rank":1833,"name":"Iscu","annotation":"Iron-sulfur cluster assembly enzyme ISCU, mitochondrial; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. C [...] "},{"id":"ENSMUSP00000086460","abundance":39.9,"rank":1834,"name":"H13","annotation":"Minor histocompatibility antigen H13; Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner (By similarity). May play a role in graft rejection. Belongs to the peptidase A22B family."},{"id":"ENSMUSP00000006952","abundance":39.9,"rank":1835,"name":"Saa4","annotation":"Serum amyloid A-4 protein; Major acute phase reactant. Apolipoprotein of the HDL complex."},{"id":"ENSMUSP00000099975","abundance":39.9,"rank":1836,"name":"Slc44a1","annotation":"Choline transporter-like protein 1; Choline transporter. May be involved in membrane synthesis and myelin production; Belongs to the CTL (choline transporter-like) family."},{"id":"ENSMUSP00000001460","abundance":39.9,"rank":1837,"name":"Snd1","annotation":"Staphylococcal nuclease domain-containing protein 1; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (By similarity). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (By similarity). Functions as a bridging factor between STAT6 and the basal transcription factor (By similarity). Plays a role in PIM1 regulation of MYB activity (By similarity). Functions as a transcriptional coactivator for STAT5."},{"id":"ENSMUSP00000108484","abundance":39.8,"rank":1838,"name":"Pak3","annotation":"Serine/threonine-protein kinase PAK 3; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstrea [...] "},{"id":"ENSMUSP00000059382","abundance":39.8,"rank":1839,"name":"Cbfb","annotation":"Core-binding factor subunit beta; Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'- TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine l [...] "},{"id":"ENSMUSP00000095695","abundance":39.8,"rank":1840,"name":"Coq7","annotation":"5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner ; Belongs to the COQ7 family."},{"id":"ENSMUSP00000025249","abundance":39.8,"rank":1841,"name":"Apom","annotation":"Apolipoprotein M; Probably involved in lipid transport. Can bind sphingosine-1- phosphate, myristic acid, palmitic acid and stearic acid, retinol, all- trans-retinoic acid and 9-cis-retinoic acid (By similarity). Belongs to the calycin superfamily. Lipocalin family. Highly divergent."},{"id":"ENSMUSP00000101473","abundance":39.8,"rank":1842,"name":"Kdm1a","annotation":"Lysine-specific histone demethylase 1A; Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demet [...] "},{"id":"ENSMUSP00000113116","abundance":39.8,"rank":1843,"name":"Stt3a","annotation":"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] "},{"id":"ENSMUSP00000034214","abundance":39.7,"rank":1844,"name":"Mt2","annotation":"Metallothionein-2; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family."},{"id":"ENSMUSP00000100599","abundance":39.7,"rank":1845,"name":"Rbm8a2","annotation":"RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs."},{"id":"ENSMUSP00000023268","abundance":39.7,"rank":1846,"name":"Arc","annotation":"Activity-regulated cytoskeleton-associated protein; Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system (By similarity). ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation (By similarity). ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons (By similarity). Acts as a key regulator of synaptic plasticity: [...] "},{"id":"ENSMUSP00000020312","abundance":39.6,"rank":1847,"name":"Mcu","annotation":"Calcium uniporter protein, mitochondrial; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex) (By similarity). Activity is regulated by MICU1 and MICU2 (By similarity). At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity (By similarity). Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and acti [...] "},{"id":"ENSMUSP00000077946","abundance":39.6,"rank":1848,"name":"Ampd2","annotation":"AMP deaminase 2; AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family."},{"id":"ENSMUSP00000039844","abundance":39.5,"rank":1849,"name":"Actr1a","annotation":"Alpha-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome."},{"id":"ENSMUSP00000036140","abundance":39.5,"rank":1850,"name":"Acsm1","annotation":"Acyl-coenzyme A synthetase ACSM1, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism. Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate- containing xenobiotics, e.g. benzoate. Also catalyzes the activation of lipoate to lipoyl- nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)- lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By simi [...] "},{"id":"ENSMUSP00000079883","abundance":39.5,"rank":1851,"name":"Timm17a","annotation":"Mitochondrial import inner membrane translocase subunit Tim17-A; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane."},{"id":"ENSMUSP00000067117","abundance":39.4,"rank":1852,"name":"Spink2","annotation":"Serine protease inhibitor Kazal-type 2; As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis. It also inhibits trypsin."},{"id":"ENSMUSP00000008477","abundance":39.4,"rank":1853,"name":"Snrpb2","annotation":"U2 small nuclear ribonucleoprotein B'; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA."},{"id":"ENSMUSP00000136589","abundance":39.4,"rank":1854,"name":"Pbld1","annotation":"Phenazine biosynthesis-like domain-containing protein 1; Belongs to the PhzF family."},{"id":"ENSMUSP00000053842","abundance":39.4,"rank":1855,"name":"Dnaja3","annotation":"DnaJ homolog subfamily A member 3, mitochondrial; Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity (By similarity). Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway."},{"id":"ENSMUSP00000031560","abundance":39.3,"rank":1856,"name":"Mmab","annotation":"Corrinoid adenosyltransferase; Adenosyltransferase involved in intracellular vitamin B12 metabolism. Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer taht is stimulated by ATP-binding to MMAB and gated by MMAA."},{"id":"ENSMUSP00000000049","abundance":39.2,"rank":1857,"name":"Apoh","annotation":"Beta-2-glycoprotein 1; Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells."},{"id":"ENSMUSP00000026416","abundance":39.2,"rank":1858,"name":"Cdk2","annotation":"Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] "},{"id":"ENSMUSP00000026487","abundance":39.2,"rank":1859,"name":"Ier3ip1","annotation":"Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus; Belongs to the YOS1 family."},{"id":"ENSMUSP00000105321","abundance":39.2,"rank":1860,"name":"Nsun2","annotation":"RNA cytosine C(5)-methyltransferase NSUN2; RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs). Involved in various processes, such as epidermal stem cell differentiation, testis differentiation and maternal to zygotic transition during early development: acts by increasing protein synthesis; cytosine C(5)-methylation promoting tRNA stability and preventing mRNA decay. Methylates cytosine to 5- methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) p [...] "},{"id":"ENSMUSP00000103402","abundance":39.2,"rank":1861,"name":"Tmod1","annotation":"Tropomodulin-1; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity); Belongs to the tropomodulin family."},{"id":"ENSMUSP00000099487","abundance":39.1,"rank":1862,"name":"Nop56","annotation":"Nucleolar protein 56; Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (By similarity). Belongs to the NOP5/NOP56 family."},{"id":"ENSMUSP00000073444","abundance":39.1,"rank":1863,"name":"Ugt1a9","annotation":"UDP-glucuronosyltransferase 1-9; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds."},{"id":"ENSMUSP00000030315","abundance":39.1,"rank":1864,"name":"Pum1","annotation":"Pumilio homolog 1; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth  [...] "},{"id":"ENSMUSP00000061935","abundance":39.1,"rank":1865,"name":"Epcam","annotation":"Epithelial cell adhesion molecule; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). Belongs to the EPCAM family."},{"id":"ENSMUSP00000021332","abundance":39,"rank":1866,"name":"Fkbp3","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP3; FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins (By similarity)."},{"id":"ENSMUSP00000032842","abundance":39,"rank":1867,"name":"Ccdc90b","annotation":"Coiled-coil domain-containing protein 90B, mitochondrial."},{"id":"ENSMUSP00000026470","abundance":39,"rank":1868,"name":"Shmt2","annotation":"Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (By similarity). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (By similarity). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (By s [...] "},{"id":"ENSMUSP00000033809","abundance":39,"rank":1869,"name":"Prps1","annotation":"Ribose-phosphate pyrophosphokinase 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis."},{"id":"ENSMUSP00000133736","abundance":39,"rank":1870,"name":"Prps1l3","annotation":"Phosphoribosyl pyrophosphate synthetase 1-like 3."},{"id":"ENSMUSP00000033609","abundance":39,"rank":1871,"name":"Cstf2","annotation":"Cleavage stimulation factor subunit 2; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs (By similarity)."},{"id":"ENSMUSP00000129157","abundance":38.9,"rank":1872,"name":"Tcea1","annotation":"Transcription elongation factor A protein 1; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus."},{"id":"ENSMUSP00000003907","abundance":38.9,"rank":1873,"name":"Gcdh","annotation":"Glutaryl-CoA dehydrogenase, mitochondrial; Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L- hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor; Belongs to the acyl-CoA dehydrogenase family."},{"id":"ENSMUSP00000131306","abundance":38.9,"rank":1874,"name":"Rbms1","annotation":"RNA-binding motif, single-stranded-interacting protein 1; Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication."},{"id":"ENSMUSP00000034355","abundance":38.8,"rank":1875,"name":"Ces2e","annotation":"Pyrethroid hydrolase Ces2e; Carboxylesterase that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes trans-permethrin at a rate about 22-fold higher than cis-permethrin. Also hydrolyzes trans-cypermethrin."},{"id":"ENSMUSP00000096686","abundance":38.7,"rank":1876,"name":"Mbnl1","annotation":"Muscleblind-like protein 1; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron  [...] "},{"id":"ENSMUSP00000023720","abundance":38.7,"rank":1877,"name":"Krt84","annotation":"Keratin, type II cuticular Hb4; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000124093","abundance":38.7,"rank":1878,"name":"Usp7","annotation":"Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presen [...] "},{"id":"ENSMUSP00000018851","abundance":38.7,"rank":1879,"name":"Dync1h1","annotation":"Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression."},{"id":"ENSMUSP00000004508","abundance":38.6,"rank":1880,"name":"Tmed4","annotation":"Transmembrane emp24 domain-containing protein 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity)."},{"id":"ENSMUSP00000042351","abundance":38.6,"rank":1881,"name":"Acaa1a","annotation":"3-ketoacyl-CoA thiolase A, peroxisomal."},{"id":"ENSMUSP00000134550","abundance":38.5,"rank":1882,"name":"H2-Q6","annotation":"H-2 class I histocompatibility antigen, Q8 alpha chain; Involved in the presentation of foreign antigens to the immune system."},{"id":"ENSMUSP00000020286","abundance":38.5,"rank":1883,"name":"Ppa1","annotation":"Inorganic pyrophosphatase; Belongs to the PPase family."},{"id":"ENSMUSP00000062539","abundance":38.5,"rank":1884,"name":"Pcp4","annotation":"Calmodulin regulator protein PCP4; Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls. For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways."},{"id":"ENSMUSP00000044178","abundance":38.5,"rank":1885,"name":"Lsm3","annotation":"U6 snRNA-associated Sm-like protein LSm3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA."},{"id":"ENSMUSP00000117246","abundance":38.5,"rank":1886,"name":"Fen1","annotation":"Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as  [...] "},{"id":"ENSMUSP00000021630","abundance":38.5,"rank":1887,"name":"Akr1c6","annotation":"Estradiol 17 beta-dehydrogenase 5; Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a- stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4- androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5-alpha- androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17-beta-diol, respectively; Belongs to the aldo/keto reductase family."},{"id":"ENSMUSP00000000287","abundance":38.5,"rank":1888,"name":"Scpep1","annotation":"Retinoid-inducible serine carboxypeptidase; May be involved in vascular wall and kidney homeostasis; Belongs to the peptidase S10 family."},{"id":"ENSMUSP00000113560","abundance":38.4,"rank":1889,"name":"Wdr61","annotation":"WD repeat-containing protein 61, N-terminally processed; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for tran [...] "},{"id":"ENSMUSP00000157291","abundance":38.3,"rank":1890,"name":"Eci1","annotation":"Enoyl-CoA delta isomerase 1, mitochondrial; Able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species."},{"id":"ENSMUSP00000082053","abundance":38.3,"rank":1891,"name":"Ppp2r5c","annotation":"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A- PPP2R5C holoenzyme may activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation (By similarity)."},{"id":"ENSMUSP00000146263","abundance":38.3,"rank":1892,"name":"Hnrnpul1","annotation":"Heterogeneous nuclear ribonucleoprotein U-like protein 1; Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid- responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro (By similarity)."},{"id":"ENSMUSP00000027127","abundance":38.3,"rank":1893,"name":"Sf3b1","annotation":"Splicing factor 3B subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. Together with other U2 snRNP complex components may also play a role in the selective processing of microRNAs (miRNAs) from the long primary miRNA transcript, pri-miR-17-92. May also be involved in the assembly [...] "},{"id":"ENSMUSP00000125341","abundance":38.2,"rank":1894,"name":"Slirp","annotation":"SRA stem-loop-interacting RNA-binding protein, mitochondrial; RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation (By similarity)."},{"id":"ENSMUSP00000022145","abundance":38.2,"rank":1895,"name":"Serf1","annotation":"Small EDRK-rich factor 1; Positive regulator of amyloid protein aggregation and proteotoxicity (By similarity). Induces conformational changes in amyloid proteins, such as APP, HTT, and SNCA, driving them into compact formations preceding the formation of aggregates (By similarity). Belongs to the SERF family."},{"id":"ENSMUSP00000040956","abundance":38.1,"rank":1896,"name":"Sccpdh","annotation":"Saccharopine dehydrogenase-like oxidoreductase; Belongs to the saccharopine dehydrogenase family."},{"id":"ENSMUSP00000031061","abundance":38.1,"rank":1897,"name":"Dhx15","annotation":"Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (By similarity). Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily."},{"id":"ENSMUSP00000112664","abundance":38.1,"rank":1898,"name":"Akr1c14","annotation":"3-alpha-hydroxysteroid dehydrogenase type 1."},{"id":"ENSMUSP00000033030","abundance":38,"rank":1899,"name":"Parva","annotation":"Alpha-parvin; Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development."},{"id":"ENSMUSP00000005256","abundance":38,"rank":1900,"name":"Ndrg1","annotation":"Protein NDRG1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy (By similarity). Has a role in cell trafficking notably of the Schwann cell and is necessary for the mai [...] "},{"id":"ENSMUSP00000029912","abundance":38,"rank":1901,"name":"Sdcbp","annotation":"Syntenin-1; Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell- surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP [...] "},{"id":"ENSMUSP00000041347","abundance":37.9,"rank":1902,"name":"Ina","annotation":"Alpha-internexin; Class-IV neuronal intermediate filament that is able to self- assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges (By similarity)."},{"id":"ENSMUSP00000022496","abundance":37.9,"rank":1903,"name":"Kpna3","annotation":"Importin subunit alpha-4; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] "},{"id":"ENSMUSP00000006137","abundance":37.9,"rank":1904,"name":"Trap1","annotation":"Heat shock protein 75 kDa, mitochondrial; Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA."},{"id":"ENSMUSP00000034547","abundance":37.8,"rank":1905,"name":"Acat1","annotation":"Acetyl-CoA acetyltransferase, mitochondrial; This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. Belongs to the thiolase-l [...] "},{"id":"ENSMUSP00000018430","abundance":37.7,"rank":1906,"name":"Psmb6","annotation":"Proteasome subunit beta type-6; Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP- dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing pro [...] "},{"id":"ENSMUSP00000027965","abundance":37.7,"rank":1907,"name":"Fam107b","annotation":"Protein FAM107B."},{"id":"ENSMUSP00000002043","abundance":37.6,"rank":1908,"name":"Ccdc47","annotation":"Coiled-coil domain-containing protein 47; Involved in the regulation of calcium ion homeostasis in the endoplasmic reticulum (By similarity). Required for proper protein degradation via the ERAD pathway. Has an essential role in the maintenance of endoplasmic reticulum organization during embryogenesis."},{"id":"ENSMUSP00000033468","abundance":37.6,"rank":1909,"name":"Arhgef6","annotation":"Rho guanine nucleotide exchange factor 6; Acts as a RAC1 guanine nucleotide exchange factor (GEF)."},{"id":"ENSMUSP00000127586","abundance":37.6,"rank":1910,"name":"Cyfip2","annotation":"Cytoplasmic FMR1-interacting protein 2; Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes ; Belongs to the CYFIP family."},{"id":"ENSMUSP00000020657","abundance":37.6,"rank":1911,"name":"Ube2b","annotation":"Ubiquitin-conjugating enzyme E2 B; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys- 120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiqui [...] "},{"id":"ENSMUSP00000066038","abundance":37.5,"rank":1912,"name":"Eif3k","annotation":"Eukaryotic translation initiation factor 3 subunit K; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] "},{"id":"ENSMUSP00000104329","abundance":37.5,"rank":1913,"name":"Myh3","annotation":"Myosin-3; Muscle contraction."},{"id":"ENSMUSP00000099989","abundance":37.5,"rank":1914,"name":"Uap1l1","annotation":"UDP-N-acetylhexosamine pyrophosphorylase-like protein 1."},{"id":"ENSMUSP00000009538","abundance":37.5,"rank":1915,"name":"Syn2","annotation":"Synapsin-2; Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons."},{"id":"ENSMUSP00000075250","abundance":37.5,"rank":1916,"name":"Cks2","annotation":"Cyclin-dependent kinases regulatory subunit 2; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function; Belongs to the CKS family."},{"id":"ENSMUSP00000025278","abundance":37.4,"rank":1917,"name":"Mrpl27","annotation":"39S ribosomal protein L27, mitochondrial; Belongs to the bacterial ribosomal protein bL27 family."},{"id":"ENSMUSP00000113500","abundance":37.4,"rank":1918,"name":"Cadm2","annotation":"Cell adhesion molecule 2; Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion. Preferentially binds to oligodendrocytes (By similarity)."},{"id":"ENSMUSP00000092409","abundance":37.4,"rank":1919,"name":"Sae1","annotation":"SUMO-activating enzyme subunit 1, N-terminally processed; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family."},{"id":"ENSMUSP00000107749","abundance":37.4,"rank":1920,"name":"Mlec","annotation":"Malectin; Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N- glycosylation (By similarity); Belongs to the malectin family."},{"id":"ENSMUSP00000098365","abundance":37.4,"rank":1921,"name":"Nufip2","annotation":"Nuclear fragile X mental retardation-interacting protein 2; Binds RNA."},{"id":"ENSMUSP00000102633","abundance":37.4,"rank":1922,"name":"Hsd3b3","annotation":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids."},{"id":"ENSMUSP00000017142","abundance":37.3,"rank":1923,"name":"Svs4","annotation":"Seminal vesicle secretory protein 4."},{"id":"ENSMUSP00000142042","abundance":37.3,"rank":1924,"name":"Tmco1","annotation":"Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store ; Belongs to the TMCO1 family."},{"id":"ENSMUSP00000073552","abundance":37.2,"rank":1925,"name":"Krt33b","annotation":"Keratin, type I cuticular Ha3-II; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000069850","abundance":37.2,"rank":1926,"name":"Cebpb","annotation":"CCAAT/enhancer-binding protein beta; Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipo [...] "},{"id":"ENSMUSP00000113660","abundance":37.2,"rank":1927,"name":"Dyrk1a","annotation":"Dual specificity tyrosine-phosphorylation-regulated kinase 1A; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Exhibits a substrate preference for proline at position P+1 and arginine at position P-3. Has pro-survival function and negatively regulates the apoptotic process. Promotes cell survival upon genotoxic stress through phosphorylation of SIRT1. This in tu [...] "},{"id":"ENSMUSP00000028288","abundance":37.2,"rank":1928,"name":"Notch1","annotation":"Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] "},{"id":"ENSMUSP00000108896","abundance":37.1,"rank":1929,"name":"Csn3","annotation":"Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk."},{"id":"ENSMUSP00000040307","abundance":37.1,"rank":1930,"name":"Map3k7","annotation":"Mitogen-activated protein kinase kinase kinase 7; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as a [...] "},{"id":"ENSMUSP00000109797","abundance":37.1,"rank":1931,"name":"Fam50a","annotation":"Protein FAM50A; May be a DNA-binding protein or transcriptional factor."},{"id":"ENSMUSP00000157844","abundance":37.1,"rank":1932,"name":"Snhg4","annotation":"Small nucleolar RNA host gene 4."},{"id":"ENSMUSP00000152169","abundance":37.1,"rank":1933,"name":"Ctsl","annotation":"Cathepsin L1 heavy chain; Thiol protease important for the overall degradation of proteins in lysosomes (Probable). Involved in the solubilization of cross-linked TG/thyroglobulin and in the subsequent release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000032824","abundance":37,"rank":1934,"name":"Psmc4","annotation":"26S proteasome regulatory subunit 6B; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated wit [...] "},{"id":"ENSMUSP00000147685","abundance":37,"rank":1935,"name":"Cks1brt","annotation":"Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function."},{"id":"ENSMUSP00000014920","abundance":37,"rank":1936,"name":"Nol3","annotation":"Nucleolar protein 3; Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BA [...] "},{"id":"ENSMUSP00000025679","abundance":37,"rank":1937,"name":"Otub1","annotation":"Ubiquitin thioesterase OTUB1; Hydrolase that can specifically remove compared to 'Lys-48'- linked conjugated ubiquitin from proteins and plays an important regulatory role at the level of protein turnover by preventing degradation. Regulator of T-cell anergy, a phenomenon that occurs when T-cells are rendered unresponsive to antigen rechallenge and no longer respond to their cognate antigen. Acts via its interaction with RNF128/GRAIL. Surprisingly, it regulates RNF128-mediated ubiquitination, but does not deubiquitinate polyubiquitinated RNF128. Deubiquitinates estrogen receptor alpha  [...] "},{"id":"ENSMUSP00000065922","abundance":37,"rank":1938,"name":"Krt72","annotation":"Keratin, type II cytoskeletal 72; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (By similarity)."},{"id":"ENSMUSP00000046480","abundance":36.9,"rank":1939,"name":"Ostc","annotation":"Oligosaccharyltransferase complex subunit OSTC; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).  [...] "},{"id":"ENSMUSP00000117616","abundance":36.9,"rank":1940,"name":"Tpr","annotation":"Nucleoprotein TPR; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA [...] "},{"id":"ENSMUSP00000047737","abundance":36.9,"rank":1941,"name":"S100a13","annotation":"Protein S100-A13; Plays a role in the export of proteins that lack a signal peptide and are secreted by an alternative pathway. Binds two calcium ions per subunit. Binds one copper ion. Binding of one copper ion does not interfere with calcium binding. Required for the copper-dependent stress-induced export of IL1A and FGF1. The calcium-free protein binds to lipid vesicles containing phosphatidylserine, but not to vesicles containing phosphatidylcholine."},{"id":"ENSMUSP00000069482","abundance":36.9,"rank":1942,"name":"Atp6v1g2","annotation":"V-type proton ATPase subunit G 2; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells."},{"id":"ENSMUSP00000056888","abundance":36.9,"rank":1943,"name":"Ubqln2","annotation":"Ubiquilin-2; Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin- proteasome system (UPS), autophagy and the endoplasmic reticulum- associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form  [...] "},{"id":"ENSMUSP00000015234","abundance":36.9,"rank":1944,"name":"Ptgds","annotation":"Prostaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] "},{"id":"ENSMUSP00000101855","abundance":36.8,"rank":1945,"name":"Trim72","annotation":"Tripartite motif-containing protein 72; Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)- depen [...] "},{"id":"ENSMUSP00000037371","abundance":36.8,"rank":1946,"name":"Echdc3","annotation":"Enoyl-CoA hydratase domain-containing protein 3, mitochondrial; May play a role in fatty acid biosynthesis and insulin sensitivity; Belongs to the enoyl-CoA hydratase/isomerase family."},{"id":"ENSMUSP00000020329","abundance":36.7,"rank":1947,"name":"Egfr","annotation":"Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] "},{"id":"ENSMUSP00000158288","abundance":36.7,"rank":1948,"name":"Tcerg1","annotation":"Transcription elongation regulator 1; Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner (By similarity)."},{"id":"ENSMUSP00000091551","abundance":36.6,"rank":1949,"name":"Abr","annotation":"Active breakpoint cluster region-related protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GD [...] "},{"id":"ENSMUSP00000114111","abundance":36.6,"rank":1950,"name":"Mrpl24","annotation":"39S ribosomal protein L24, mitochondrial; Belongs to the universal ribosomal protein uL24 family."},{"id":"ENSMUSP00000082827","abundance":36.6,"rank":1951,"name":"Smurf1","annotation":"E3 ubiquitin-protein ligase SMURF1; E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway (By similarity). Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of MAVS. Plays a role in dendrite formation by melanocytes (By similarity)."},{"id":"ENSMUSP00000135040","abundance":36.5,"rank":1952,"name":"Tppp3","annotation":"Tubulin polymerization-promoting protein family member 3; Regulator of microtubule dynamic that has microtubule bundling activity (By similarity). Required for embryo implantation; possibly by regulating beta-catenin. Also required for decidualization via regulation of beta-catenin. Belongs to the TPPP family."},{"id":"ENSMUSP00000112386","abundance":36.5,"rank":1953,"name":"Gm21987","annotation":"Cytochrome c oxidase copper chaperone; Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2)."},{"id":"ENSMUSP00000113430","abundance":36.5,"rank":1954,"name":"Cox17","annotation":"Cytochrome c oxidase assembly protein 17, copper chaperone."},{"id":"ENSMUSP00000103788","abundance":36.4,"rank":1955,"name":"Rngtt","annotation":"Polynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus."},{"id":"ENSMUSP00000029477","abundance":36.3,"rank":1956,"name":"Slc25a24","annotation":"Calcium-binding mitochondrial carrier protein SCaMC-1; Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitoc [...] "},{"id":"ENSMUSP00000034567","abundance":36.3,"rank":1957,"name":"Dlat","annotation":"Dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle."},{"id":"ENSMUSP00000030538","abundance":36.2,"rank":1958,"name":"Ddost","annotation":"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] "},{"id":"ENSMUSP00000037665","abundance":36.2,"rank":1959,"name":"Cyp3a11","annotation":"Cytochrome P450 3A11; Catalyzes erythromycin N-demethylation, nifedipine oxidation and testosterone 6 beta-hydroxylation; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000097629","abundance":36.2,"rank":1960,"name":"Igf2bp2","annotation":"Insulin-like growth factor 2 mRNA-binding protein 2; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform- specific. Binds to beta-actin/ACTB and MYC transcripts (By similarity)."},{"id":"ENSMUSP00000017572","abundance":36.2,"rank":1961,"name":"Psmd11","annotation":"26S proteasome non-ATPase regulatory subunit 11; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. P [...] "},{"id":"ENSMUSP00000044554","abundance":36,"rank":1962,"name":"Fermt2","annotation":"Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and ce [...] "},{"id":"ENSMUSP00000095866","abundance":36,"rank":1963,"name":"Arrb1","annotation":"Beta-arrestin-1; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] "},{"id":"ENSMUSP00000120904","abundance":36,"rank":1964,"name":"Tmed7","annotation":"Transmembrane p24-trafficking protein 7."},{"id":"ENSMUSP00000069133","abundance":36,"rank":1965,"name":"Babam2","annotation":"BRISC and BRCA1-A complex member 2; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integri [...] "},{"id":"ENSMUSP00000116746","abundance":36,"rank":1966,"name":"Mrpl58","annotation":"Peptidyl-tRNA hydrolase ICT1, mitochondrial; Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes (By similarity)."},{"id":"ENSMUSP00000129186","abundance":35.9,"rank":1967,"name":"Tomm70a","annotation":"Mitochondrial import receptor subunit TOM70; Receptor that accelerates the import of all mitochondrial precursor proteins."},{"id":"ENSMUSP00000056836","abundance":35.9,"rank":1968,"name":"Cfd","annotation":"Complement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway."},{"id":"ENSMUSP00000064758","abundance":35.9,"rank":1969,"name":"Atl2","annotation":"Atlastin-2; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily."},{"id":"ENSMUSP00000028160","abundance":35.9,"rank":1970,"name":"Slc25a25","annotation":"Calcium-binding mitochondrial carrier protein SCaMC-2; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria (By similarity)."},{"id":"ENSMUSP00000076433","abundance":35.9,"rank":1971,"name":"Ethe1","annotation":"Persulfide dioxygenase ETHE1, mitochondrial; First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (By similarity). Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has  [...] "},{"id":"ENSMUSP00000027494","abundance":35.9,"rank":1972,"name":"Ppp1r7","annotation":"Protein phosphatase 1 regulatory subunit 7; Regulatory subunit of protein phosphatase 1."},{"id":"ENSMUSP00000106968","abundance":35.9,"rank":1973,"name":"Sdhc","annotation":"Succinate dehydrogenase cytochrome b560 subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)."},{"id":"ENSMUSP00000086530","abundance":35.9,"rank":1974,"name":"Cyp2d9","annotation":"Cytochrome P450 2D9; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000031190","abundance":35.9,"rank":1975,"name":"Dr1","annotation":"Protein Dr1; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity); Belongs to the NC2 beta/DR1 family."},{"id":"ENSMUSP00000107192","abundance":35.9,"rank":1976,"name":"Clip1","annotation":"CAP-Gly domain-containing linker protein 1; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking."},{"id":"ENSMUSP00000022816","abundance":35.8,"rank":1977,"name":"Sub1","annotation":"Activated RNA polymerase II transcriptional coactivator p15; General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA)."},{"id":"ENSMUSP00000047761","abundance":35.7,"rank":1978,"name":"Glyctk","annotation":"Glycerate kinase; Belongs to the glycerate kinase type-2 family."},{"id":"ENSMUSP00000149505","abundance":35.7,"rank":1979,"name":"Siae","annotation":"Sialate O-acetylesterase large subunit; Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, N-acetylneuraminic acid."},{"id":"ENSMUSP00000071914","abundance":35.6,"rank":1980,"name":"Mprip","annotation":"Myosin phosphatase Rho-interacting protein; Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin- binding region leads to disassembly of stress fibers in neuronal cells."},{"id":"ENSMUSP00000030201","abundance":35.6,"rank":1981,"name":"Gne","annotation":"Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; Regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. Required for normal sialylation in hematopoietic cells (By similarity). Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. Plays an essential role in early development; In the N-terminal section; belongs to the UDP-N- acetylglucosamine 2-epimerase family."},{"id":"ENSMUSP00000026262","abundance":35.6,"rank":1982,"name":"Hexa","annotation":"Beta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues."},{"id":"ENSMUSP00000143680","abundance":35.6,"rank":1983,"name":"Crip1","annotation":"Cysteine-rich protein 1; Seems to have a role in zinc absorption and may function as an intracellular zinc transport protein."},{"id":"ENSMUSP00000057238","abundance":35.6,"rank":1984,"name":"Lsm8","annotation":"U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA."},{"id":"ENSMUSP00000139376","abundance":35.6,"rank":1985,"name":"C1rb","annotation":"Complement C1r-B subcomponent heavy chain; C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system."},{"id":"ENSMUSP00000112977","abundance":35.6,"rank":1986,"name":"Mrpl1","annotation":"39S ribosomal protein L1, mitochondrial."},{"id":"ENSMUSP00000020283","abundance":35.6,"rank":1987,"name":"Macroh2a2","annotation":"Core histone macro-H2A.2; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inact [...] "},{"id":"ENSMUSP00000142732","abundance":35.6,"rank":1988,"name":"Pitpnb","annotation":"Phosphatidylinositol transfer protein beta isoform; Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes."},{"id":"ENSMUSP00000023590","abundance":35.5,"rank":1989,"name":"Hrg","annotation":"Histidine-rich glycoprotein; Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell  [...] "},{"id":"ENSMUSP00000026560","abundance":35.5,"rank":1990,"name":"Psmd13","annotation":"26S proteasome non-ATPase regulatory subunit 13; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S11 family."},{"id":"ENSMUSP00000004774","abundance":35.5,"rank":1991,"name":"Aqp1","annotation":"Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient."},{"id":"ENSMUSP00000114304","abundance":35.4,"rank":1992,"name":"Aldh1l1","annotation":"Cytosolic 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family."},{"id":"ENSMUSP00000082723","abundance":35.4,"rank":1993,"name":"Lsm14a","annotation":"Protein LSM14 homolog A; Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. Belongs to the LSM14 family."},{"id":"ENSMUSP00000029643","abundance":35.4,"rank":1994,"name":"Gar1","annotation":"H/ACA ribonucleoprotein complex subunit 1; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] "},{"id":"ENSMUSP00000025439","abundance":35.4,"rank":1995,"name":"Me2","annotation":"NAD-dependent malic enzyme, mitochondrial."},{"id":"ENSMUSP00000023598","abundance":35.3,"rank":1996,"name":"Rfc4","annotation":"Replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity)."},{"id":"ENSMUSP00000035417","abundance":35.3,"rank":1997,"name":"Pklr","annotation":"Pyruvate kinase PKLR; Plays a key role in glycolysis."},{"id":"ENSMUSP00000025541","abundance":35.3,"rank":1998,"name":"Gnaq","annotation":"Guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM- derived neutrophils and dendritic cells (in vitro). Belongs to the G-alpha family. G(q) subfamily."},{"id":"ENSMUSP00000023559","abundance":35.2,"rank":1999,"name":"Ehhadh","annotation":"Enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family."},{"id":"ENSMUSP00000076971","abundance":35.2,"rank":2000,"name":"Ssrp1","annotation":"FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] "},{"id":"ENSMUSP00000020463","abundance":35.2,"rank":2001,"name":"Ncln","annotation":"Nicalin; May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning."},{"id":"ENSMUSP00000028583","abundance":35.2,"rank":2002,"name":"Lin7c","annotation":"Protein lin-7 homolog C; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may funct [...] "},{"id":"ENSMUSP00000132348","abundance":35.1,"rank":2003,"name":"Sec61g","annotation":"Protein transport protein Sec61 subunit gamma; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER)."},{"id":"ENSMUSP00000145468","abundance":35.1,"rank":2004,"name":"Hspa4l","annotation":"Heat shock 70 kDa protein 4L; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase."},{"id":"ENSMUSP00000039133","abundance":35.1,"rank":2005,"name":"Ythdc1","annotation":"YTH domain-containing protein 1; Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs (By similarity). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (By similarity). Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 (By similarity). Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-b [...] "},{"id":"ENSMUSP00000032629","abundance":35.1,"rank":2006,"name":"Cyfip1","annotation":"Cytoplasmic FMR1-interacting protein 1; Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E- FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with th [...] "},{"id":"ENSMUSP00000026302","abundance":35.1,"rank":2007,"name":"Maged2","annotation":"Melanoma antigen, family D, 2."},{"id":"ENSMUSP00000147383","abundance":35.1,"rank":2008,"name":"Nucb1","annotation":"Nucleobindin-1; Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (By similarity)."},{"id":"ENSMUSP00000081370","abundance":35.1,"rank":2009,"name":"Cyp4a12a","annotation":"Cytochrome P450 4A12A; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates [...] "},{"id":"ENSMUSP00000022821","abundance":35,"rank":2010,"name":"Dhrs4","annotation":"Dehydrogenase/reductase SDR family member 4; Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha- dicarbonyl compounds with aromatic rings, such as pyrimidine-4- aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4- hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity)."},{"id":"ENSMUSP00000124846","abundance":35,"rank":2011,"name":"Tra2b","annotation":"Transformer-2 protein homolog beta; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA (By similarity); Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000020522","abundance":34.9,"rank":2012,"name":"Pfkl","annotation":"ATP-dependent 6-phosphofructokinase, liver type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway ; Belongs to the phosphofructokinase type A (PFKA) fami [...] "},{"id":"ENSMUSP00000101825","abundance":34.9,"rank":2013,"name":"Kyat3","annotation":"Kynurenine--oxoglutarate transaminase 3; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro)."},{"id":"ENSMUSP00000017488","abundance":34.8,"rank":2014,"name":"Vtn","annotation":"Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway."},{"id":"ENSMUSP00000034172","abundance":34.8,"rank":2015,"name":"Ces1d","annotation":"Carboxylesterase 1D; Major lipase in white adipose tissue. Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters."},{"id":"ENSMUSP00000108124","abundance":34.8,"rank":2016,"name":"Pgam5","annotation":"Serine/threonine-protein phosphatase PGAM5, mitochondrial; Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression (By similarity). Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore."},{"id":"ENSMUSP00000086312","abundance":34.8,"rank":2017,"name":"Gtf2f2","annotation":"General transcription factor IIF subunit 2; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity (By similarity)."},{"id":"ENSMUSP00000113852","abundance":34.7,"rank":2018,"name":"Syk","annotation":"Tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can a [...] "},{"id":"ENSMUSP00000090633","abundance":34.7,"rank":2019,"name":"Ahnak","annotation":"AHNAK nucleoprotein (desmoyokin)."},{"id":"ENSMUSP00000029773","abundance":34.7,"rank":2020,"name":"Cnn3","annotation":"Calponin-3; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity)."},{"id":"ENSMUSP00000003964","abundance":34.7,"rank":2021,"name":"Gys1","annotation":"Glycogen [starch] synthase, muscle; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Belongs to the glycosyltransferase 3 family."},{"id":"ENSMUSP00000026427","abundance":34.6,"rank":2022,"name":"Esyt1","annotation":"Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane (By similarity)."},{"id":"ENSMUSP00000082793","abundance":34.6,"rank":2023,"name":"Nptn","annotation":"Neuroplastin."},{"id":"ENSMUSP00000040222","abundance":34.6,"rank":2024,"name":"Lap3","annotation":"Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity)."},{"id":"ENSMUSP00000034131","abundance":34.6,"rank":2025,"name":"Vps35","annotation":"Vacuolar protein sorting-associated protein 35; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of low affinity and retromer SNX proteins may  [...] "},{"id":"ENSMUSP00000005431","abundance":34.6,"rank":2026,"name":"Letm1","annotation":"Mitochondrial proton/calcium exchanger protein; Mitochondrial proton/calcium antiporter that mediates proton- dependent calcium efflux from mitochondrion. Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (By similarity); Belongs to the LETM1 family."},{"id":"ENSMUSP00000096547","abundance":34.6,"rank":2027,"name":"Smarca4","annotation":"Transcription activator BRG1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium- dependent release of a repressor complex and the recruitment of an activator complex. In resting ne [...] "},{"id":"ENSMUSP00000026196","abundance":34.5,"rank":2028,"name":"Got1","annotation":"Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] "},{"id":"ENSMUSP00000024956","abundance":34.5,"rank":2029,"name":"Rhoq","annotation":"Rho-related GTP-binding protein RhoQ; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia (By similarity)."},{"id":"ENSMUSP00000070596","abundance":34.5,"rank":2030,"name":"Pfdn4","annotation":"Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family."},{"id":"ENSMUSP00000108760","abundance":34.5,"rank":2031,"name":"Ugt1a7c","annotation":"UDP glucuronosyltransferase 1 family, polypeptide A7C."},{"id":"ENSMUSP00000108759","abundance":34.5,"rank":2032,"name":"Ugt1a6a","annotation":"UDP-glucuronosyltransferase 1-6; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4- nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4- hydroxybiphenyl, androgens and estrogens are not substrates. 2- hydroxybiphenyl is an excellent substrate; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000048350","abundance":34.4,"rank":2033,"name":"Vat1","annotation":"Synaptic vesicle membrane protein VAT-1 homolog; Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation (By similarity). Possesses ATPase activity. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2) (By similarity); Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily."},{"id":"ENSMUSP00000152618","abundance":34.4,"rank":2034,"name":"Atp5mpl","annotation":"ATP synthase subunit ATP5MPL, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...] "},{"id":"ENSMUSP00000033498","abundance":34.4,"rank":2035,"name":"Timm17b","annotation":"Mitochondrial import inner membrane translocase subunit Tim17-B; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane."},{"id":"ENSMUSP00000030398","abundance":34.3,"rank":2036,"name":"Slc2a1","annotation":"Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity); Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily."},{"id":"ENSMUSP00000104216","abundance":34.3,"rank":2037,"name":"0610010K14Rik","annotation":"Chromatin complexes subunit BAP18; Component of chromatin complexes such as the MLL1/MLL and NURF complexes."},{"id":"ENSMUSP00000100058","abundance":34.3,"rank":2038,"name":"Ube2h","annotation":"Ubiquitin-conjugating enzyme E2 H; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A."},{"id":"ENSMUSP00000020315","abundance":34.3,"rank":2039,"name":"Cand1","annotation":"Cullin-associated NEDD8-dissociated protein 1; Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar  [...] "},{"id":"ENSMUSP00000031613","abundance":34.3,"rank":2040,"name":"Aimp2","annotation":"Aminoacyl tRNA synthase complex-interacting multifunctional protein 2; Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor."},{"id":"ENSMUSP00000033544","abundance":34.3,"rank":2041,"name":"Brcc3","annotation":"Lys-63-specific deubiquitinase BRCC36; Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- [...] "},{"id":"ENSMUSP00000080997","abundance":34.3,"rank":2042,"name":"mt-Co3","annotation":"Cytochrome c oxidase subunit 3; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and t [...] "},{"id":"ENSMUSP00000066359","abundance":34.3,"rank":2043,"name":"Fam49b","annotation":"Protein FAM49B."},{"id":"ENSMUSP00000137303","abundance":34.3,"rank":2044,"name":"Rnaset2b","annotation":"Ribonuclease T2-A; Has ribonuclease activity, with higher activity at acidic pH. May play a role in cellular RNA catabolism. Probably is involved in lysosomal degradation of ribosomal RNA."},{"id":"ENSMUSP00000156083","abundance":34.3,"rank":2045,"name":"Rnaset2a","annotation":"Ribonuclease T2A."},{"id":"ENSMUSP00000006381","abundance":34.2,"rank":2046,"name":"Fblim1","annotation":"Filamin-binding LIM protein 1; Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity)."},{"id":"ENSMUSP00000033871","abundance":34.2,"rank":2047,"name":"Slc25a15","annotation":"Mitochondrial ornithine transporter 1; Ornithine-citrulline antiporter. Connects the cytosolic and the intramitochondrial reactions of the urea cycle by exchanging cytosolic ornithine with matrix citrulline. The stoichiometry is close to 1:1 (By similarity)."},{"id":"ENSMUSP00000030491","abundance":34.1,"rank":2048,"name":"Cmpk1","annotation":"UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily."},{"id":"ENSMUSP00000013773","abundance":34.1,"rank":2049,"name":"Cad","annotation":"Glutamine-dependent carbamoyl-phosphate synthase; This protein is a 'fusion' protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase)."},{"id":"ENSMUSP00000125531","abundance":34.1,"rank":2050,"name":"C1s1","annotation":"Complement C1s-A subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity); Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000002839","abundance":34.1,"rank":2051,"name":"Ppp2r5d","annotation":"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit."},{"id":"ENSMUSP00000090470","abundance":34.1,"rank":2052,"name":"Msi2","annotation":"RNA-binding protein Musashi homolog 2; RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Belongs to the Musashi family."},{"id":"ENSMUSP00000108058","abundance":34,"rank":2053,"name":"Cops7a","annotation":"COP9 signalosome complex subunit 7a; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] "},{"id":"ENSMUSP00000073667","abundance":34,"rank":2054,"name":"Mup20","annotation":"Major urinary protein 20; Male pheromone which stimulates female sexual attraction to male urinary scent and promotes a strong learned attraction to the airborne urinary odor of an individual male. Promotes male aggressive behavior. Binds most of the male pheromone, 2-sec-butyl-4,5- dihydrothiazole, in urine; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000043424","abundance":33.9,"rank":2055,"name":"Acad11","annotation":"Acyl-CoA dehydrogenase family member 11; Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA. Probably participates to beta-oxydation and energy production but could also play role in the metabolism of specific fatty acids to control fatty acids composition of cellular lipids in brain."},{"id":"ENSMUSP00000101616","abundance":33.9,"rank":2056,"name":"Snrnp40","annotation":"U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome."},{"id":"ENSMUSP00000048678","abundance":33.9,"rank":2057,"name":"Pakap","annotation":"A-kinase anchor protein 2; Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP."},{"id":"ENSMUSP00000031058","abundance":33.9,"rank":2058,"name":"Mapre3","annotation":"Microtubule-associated protein RP/EB family member 3; Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non- centrosomal minus-end microtubules to the Golgi, an important step for polarized [...] "},{"id":"ENSMUSP00000096280","abundance":33.9,"rank":2059,"name":"Arhgef1","annotation":"Rho guanine nucleotide exchange factor 1; Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation. Isoform 3 and isoform 4 do not homooligomerize and show an enhanced RhoGEF activity."},{"id":"ENSMUSP00000030128","abundance":33.8,"rank":2060,"name":"Chmp5","annotation":"Charged multivesicular body protein 5; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the  [...] "},{"id":"ENSMUSP00000060028","abundance":33.8,"rank":2061,"name":"Crlf3","annotation":"Cytokine receptor-like factor 3; May play a role in the negative regulation of cell cycle progression."},{"id":"ENSMUSP00000021773","abundance":33.7,"rank":2062,"name":"Gpld1","annotation":"Phosphatidylinositol-glycan-specific phospholipase D; This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane."},{"id":"ENSMUSP00000025163","abundance":33.7,"rank":2063,"name":"Pfdn6","annotation":"Prefoldin subunit 6; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity)."},{"id":"ENSMUSP00000128889","abundance":33.7,"rank":2064,"name":"Fbll1","annotation":"rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1; S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Also acts as a protein methyltransferase by mediating methylation of glutamine residues (By similarity)."},{"id":"ENSMUSP00000053474","abundance":33.7,"rank":2065,"name":"Fubp3","annotation":"Far upstream element (FUSE)-binding protein 3."},{"id":"ENSMUSP00000033770","abundance":33.7,"rank":2066,"name":"Mecp2","annotation":"Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)- containing DNA, with a preference for 5-methylcytosine (5mC)."},{"id":"ENSMUSP00000107620","abundance":33.6,"rank":2067,"name":"Gm4788","annotation":"Predicted gene 4788."},{"id":"ENSMUSP00000067681","abundance":33.6,"rank":2068,"name":"Sec61b","annotation":"Protein transport protein Sec61 subunit beta; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Required for PKD1/Polycystin-1 biogenesis."},{"id":"ENSMUSP00000095129","abundance":33.6,"rank":2069,"name":"Hdhd2","annotation":"Haloacid dehalogenase-like hydrolase domain-containing protein 2; Belongs to the HAD-like hydrolase superfamily."},{"id":"ENSMUSP00000006704","abundance":33.6,"rank":2070,"name":"Itih1","annotation":"Inter-alpha-trypsin inhibitor heavy chain H1; May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes; Belongs to the ITIH family."},{"id":"ENSMUSP00000122733","abundance":33.6,"rank":2071,"name":"Tnni2","annotation":"Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity."},{"id":"ENSMUSP00000099776","abundance":33.5,"rank":2072,"name":"Stk39","annotation":"STE20/SPS1-related proline-alanine-rich protein kinase; May act as a mediator of stress-activated signals. Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities by the WNK scaffolds, probably through phosphorylation. Phosphorylates RELT."},{"id":"ENSMUSP00000153064","abundance":33.5,"rank":2073,"name":"Hmgcs1","annotation":"Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase."},{"id":"ENSMUSP00000055862","abundance":33.4,"rank":2074,"name":"Arf6","annotation":"ADP-ribosylation factor 6; GTP-binding protein involved in protein trafficking that regulates endocytic recycling and cytoskeleton remodeling. Required for normal completion of mitotic cytokinesis. Involved in the regulation of dendritic spine development, contributing to the regulation of dendritic branching and filopodia extension. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization. Regulates surface levels of adherens junction proteins such as CDH1. Required for NTRK1 sorting to the recycling pathway from early endosomes (By sim [...] "},{"id":"ENSMUSP00000077753","abundance":33.4,"rank":2075,"name":"Gid8","annotation":"Glucose-induced degradation protein 8 homolog; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation."},{"id":"ENSMUSP00000094515","abundance":33.3,"rank":2076,"name":"Hnrnpul2","annotation":"Heterogeneous nuclear ribonucleoprotein U-like protein 2."},{"id":"ENSMUSP00000085218","abundance":33.3,"rank":2077,"name":"Stx16","annotation":"Syntaxin-16; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network; Belongs to the syntaxin family."},{"id":"ENSMUSP00000022296","abundance":33.2,"rank":2078,"name":"Ube2e1","annotation":"Ubiquitin-conjugating enzyme E2 E1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination. Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000120414","abundance":33.2,"rank":2079,"name":"Ythdf2","annotation":"YTH domain-containing family protein 2; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context. M6A- containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC- 3') are preferentially degraded by endoribonucleolytic c [...] "},{"id":"ENSMUSP00000112076","abundance":33.2,"rank":2080,"name":"Cstf1","annotation":"Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs (By similarity). May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA (By similarity)."},{"id":"ENSMUSP00000004868","abundance":33.2,"rank":2081,"name":"Mtfp1","annotation":"Mitochondrial fission process protein 1; Involved in the mitochondrial division probably by regulating membrane fission. Loss-of-function leads to apoptosis (By similarity). Belongs to the MTFP1 family."},{"id":"ENSMUSP00000003843","abundance":33.2,"rank":2082,"name":"Man1a","annotation":"Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family."},{"id":"ENSMUSP00000038763","abundance":33.2,"rank":2083,"name":"Pcca","annotation":"Propionyl-CoA carboxylase alpha chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl car [...] "},{"id":"ENSMUSP00000090637","abundance":33.1,"rank":2084,"name":"Asgr1","annotation":"Asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface."},{"id":"ENSMUSP00000071292","abundance":33.1,"rank":2085,"name":"Bckdha","annotation":"2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3); Belongs to the BCKDHA family."},{"id":"ENSMUSP00000028279","abundance":33,"rank":2086,"name":"Strbp","annotation":"Spermatid perinuclear RNA-binding protein; Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth (By similarity). Binds to double-stranded DNA and RNA (By similarity). Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA (By similarity). Binds also to single-stranded poly(G) RNA (By similarity). Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA."},{"id":"ENSMUSP00000087073","abundance":32.9,"rank":2087,"name":"Htra2","annotation":"Serine protease HTRA2, mitochondrial; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase- independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis (By similarity). Belongs to the peptidase S1C family."},{"id":"ENSMUSP00000097444","abundance":32.9,"rank":2088,"name":"Prep","annotation":"Prolyl endopeptidase; Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long."},{"id":"ENSMUSP00000059717","abundance":32.9,"rank":2089,"name":"Samhd1","annotation":"Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; [Isoform 1]: Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. [...] "},{"id":"ENSMUSP00000100911","abundance":32.9,"rank":2090,"name":"Osbpl8","annotation":"Oxysterol-binding protein-related protein 8; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol."},{"id":"ENSMUSP00000108763","abundance":32.8,"rank":2091,"name":"Ugt1a6b","annotation":"UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000034234","abundance":32.8,"rank":2092,"name":"Coq9","annotation":"Ubiquinone biosynthesis protein COQ9, mitochondrial; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Binds a phospholipid of at least 10 carbons in each acyl group. May be required to present its bound-lipid to COQ7 (By similarity). Belongs to the COQ9 family."},{"id":"ENSMUSP00000043061","abundance":32.8,"rank":2093,"name":"Mpst","annotation":"3-mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is re [...] "},{"id":"ENSMUSP00000116090","abundance":32.8,"rank":2094,"name":"Mrpl48","annotation":"39S ribosomal protein L48, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL48 family."},{"id":"ENSMUSP00000029490","abundance":32.8,"rank":2095,"name":"Ahcyl1","annotation":"S-adenosylhomocysteine hydrolase-like protein 1; Multifaceted cellular regulator which coordinates several essential cellular functions including regulation of epithelial HCO3(-) and fluid secretion, mRNA processing and DNA replication. Regulates ITPR1 sensitivity to inositol 1,4,5-trisphosphate competing for the common binding site and acting as endogenous 'pseudoligand' whose inhibitory activity can be modulated by its phosphorylation status. In the pancreatic and salivary ducts, at resting state, attenuates inositol 1,4,5-trisphosphate-induced calcium release by interacting with ITP [...] "},{"id":"ENSMUSP00000028382","abundance":32.7,"rank":2096,"name":"Nup35","annotation":"Nucleoporin NUP35; Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC (By similarity)."},{"id":"ENSMUSP00000004396","abundance":32.7,"rank":2097,"name":"Atp6v1f","annotation":"V-type proton ATPase subunit F; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells."},{"id":"ENSMUSP00000002844","abundance":32.7,"rank":2098,"name":"Mrpl2","annotation":"39S ribosomal protein L2, mitochondrial; Belongs to the universal ribosomal protein uL2 family."},{"id":"ENSMUSP00000030028","abundance":32.7,"rank":2099,"name":"Erp44","annotation":"Endoplasmic reticulum resident protein 44; Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum (By similarity)."},{"id":"ENSMUSP00000069744","abundance":32.6,"rank":2100,"name":"Rara","annotation":"Retinoic acid receptor alpha; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcri [...] "},{"id":"ENSMUSP00000105349","abundance":32.6,"rank":2101,"name":"Mta1","annotation":"Metastasis-associated protein MTA1; Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone- deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 [...] "},{"id":"ENSMUSP00000137103","abundance":32.5,"rank":2102,"name":"Emc1","annotation":"ER membrane protein complex subunit 1."},{"id":"ENSMUSP00000099555","abundance":32.5,"rank":2103,"name":"Lrrc57","annotation":"Leucine-rich repeat-containing protein 57."},{"id":"ENSMUSP00000039172","abundance":32.5,"rank":2104,"name":"Hspb6","annotation":"Heat shock protein beta-6; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity."},{"id":"ENSMUSP00000069752","abundance":32.4,"rank":2105,"name":"Rras2","annotation":"Ras-related protein R-Ras2; It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion."},{"id":"ENSMUSP00000025668","abundance":32.4,"rank":2106,"name":"Atl3","annotation":"Atlastin-3; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily."},{"id":"ENSMUSP00000104324","abundance":32.4,"rank":2107,"name":"Myh13","annotation":"Myosin, heavy polypeptide 13, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000002603","abundance":32.4,"rank":2108,"name":"Scrib","annotation":"Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicle [...] "},{"id":"ENSMUSP00000026576","abundance":32.4,"rank":2109,"name":"Taldo1","annotation":"Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway."},{"id":"ENSMUSP00000005964","abundance":32.4,"rank":2110,"name":"Adh5","annotation":"Alcohol dehydrogenase class-3; Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol."},{"id":"ENSMUSP00000034121","abundance":32.3,"rank":2111,"name":"Man2b1","annotation":"Lysosomal alpha-mannosidase; Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover; Belongs to the glycosyl hydrolase 38 family."},{"id":"ENSMUSP00000065337","abundance":32.3,"rank":2112,"name":"Asna1","annotation":"ATPase Asna1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion.  [...] "},{"id":"ENSMUSP00000103068","abundance":32.3,"rank":2113,"name":"Alad","annotation":"Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family."},{"id":"ENSMUSP00000099979","abundance":32.3,"rank":2114,"name":"Smc2","annotation":"Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity)."},{"id":"ENSMUSP00000008733","abundance":32.3,"rank":2115,"name":"Dnajb6","annotation":"DnaJ homolog subfamily B member 6; Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose- dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity)."},{"id":"ENSMUSP00000065987","abundance":32.3,"rank":2116,"name":"Ddx1","annotation":"ATP-dependent RNA helicase DDX1; Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double- strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation (By similarity). Acts as a positive transcriptional regulator of cycl [...] "},{"id":"ENSMUSP00000006094","abundance":32.3,"rank":2117,"name":"Cyp2d26","annotation":"Cytochrome P450 2D26; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000080600","abundance":32.3,"rank":2118,"name":"Nmt2","annotation":"Glycylpeptide N-tetradecanoyltransferase 2; Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins."},{"id":"ENSMUSP00000069432","abundance":32.3,"rank":2119,"name":"Gcn1","annotation":"eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity (By similarity). Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4 [...] "},{"id":"ENSMUSP00000022416","abundance":32.3,"rank":2120,"name":"Anxa11","annotation":"Annexin A11; Required for midbody formation and completion of the terminal phase of cytokinesis (By similarity). Binds specifically to calcyclin in a calcium-dependent manner; Belongs to the annexin family."},{"id":"ENSMUSP00000040853","abundance":32.2,"rank":2121,"name":"Agmat","annotation":"Agmatinase, mitochondrial."},{"id":"ENSMUSP00000125656","abundance":32.2,"rank":2122,"name":"Gfm2","annotation":"Ribosome-releasing factor 2, mitochondrial; Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily."},{"id":"ENSMUSP00000080908","abundance":32.2,"rank":2123,"name":"Mup5","annotation":"Major urinary protein 5; Major urinary proteins (Mups) bind pheromones, and thus stabilize them to allow slow release into the air from urine marks. May protect pheromones from oxidation. May also act as pheromones themselves. In this context, they play a role in the regulation of social behaviors, such as aggression, mating, pup-suckling, territory establishment and dominance; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000063287","abundance":32.2,"rank":2124,"name":"Sprr2k","annotation":"Small proline-rich protein 2K; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)."},{"id":"ENSMUSP00000005830","abundance":32.1,"rank":2125,"name":"Bcas2","annotation":"Pre-mRNA-splicing factor SPF27; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. The PRP19- CDC5L complex may also play a role in the response to DNA damage (DDR)."},{"id":"ENSMUSP00000040591","abundance":32.1,"rank":2126,"name":"Aldh5a1","annotation":"Succinate-semialdehyde dehydrogenase, mitochondrial; Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA); Belongs to the aldehyde dehydrogenase family."},{"id":"ENSMUSP00000075721","abundance":32.1,"rank":2127,"name":"Fbxw11","annotation":"F-box/WD repeat-containing protein 11; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediat [...] "},{"id":"ENSMUSP00000020759","abundance":32.1,"rank":2128,"name":"Efemp1","annotation":"EGF-containing fibulin-like extracellular matrix protein 1; Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth (By similarity); Belongs to the fibulin family."},{"id":"ENSMUSP00000034738","abundance":32.1,"rank":2129,"name":"Rsl24d1","annotation":"Probable ribosome biogenesis protein RLP24; Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By similarity)."},{"id":"ENSMUSP00000129178","abundance":32,"rank":2130,"name":"Pfdn5","annotation":"Prefoldin subunit 5; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC (By similarity)."},{"id":"ENSMUSP00000112810","abundance":32,"rank":2131,"name":"Nfyc","annotation":"Nuclear transcription factor Y subunit gamma; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors."},{"id":"ENSMUSP00000021297","abundance":32,"rank":2132,"name":"Lsm12","annotation":"Protein LSM12 homolog; Belongs to the LSM12 family."},{"id":"ENSMUSP00000003386","abundance":32,"rank":2133,"name":"Mrpl4","annotation":"39S ribosomal protein L4, mitochondrial; Belongs to the universal ribosomal protein uL4 family."},{"id":"ENSMUSP00000035804","abundance":32,"rank":2134,"name":"Marc1","annotation":"Mitochondrial amidoxime-reducing component 1; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] "},{"id":"ENSMUSP00000028233","abundance":31.9,"rank":2135,"name":"Hc","annotation":"Complement C5 alpha' chain; Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled."},{"id":"ENSMUSP00000131684","abundance":31.9,"rank":2136,"name":"Mark2","annotation":"Serine/threonine-protein kinase MARK2; Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual ac [...] "},{"id":"ENSMUSP00000105445","abundance":31.9,"rank":2137,"name":"Bcl2l1","annotation":"Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(S) promotes apoptosis; Belongs to the Bcl-2 family."},{"id":"ENSMUSP00000124551","abundance":31.9,"rank":2138,"name":"Eif4g2","annotation":"Eukaryotic translation initiation factor 4 gamma 2; Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases."},{"id":"ENSMUSP00000108767","abundance":31.9,"rank":2139,"name":"Ugt1a10","annotation":"UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000078682","abundance":31.8,"rank":2140,"name":"Ctbp1","annotation":"C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation."},{"id":"ENSMUSP00000110377","abundance":31.8,"rank":2141,"name":"Dpysl5","annotation":"Dihydropyrimidinase-related protein 5; May have a function in neuronal differentiation and/or axon growth."},{"id":"ENSMUSP00000029463","abundance":31.7,"rank":2142,"name":"Hsd3b6","annotation":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 6; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. May be involved in local production of progesterone."},{"id":"ENSMUSP00000156707","abundance":31.7,"rank":2143,"name":"Snrpc","annotation":"U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region."},{"id":"ENSMUSP00000109915","abundance":31.6,"rank":2144,"name":"Rcn2","annotation":"Reticulocalbin-2; Not known. Binds calcium (By similarity)."},{"id":"ENSMUSP00000060779","abundance":31.6,"rank":2145,"name":"Lyrm4","annotation":"LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family."},{"id":"ENSMUSP00000038559","abundance":31.5,"rank":2146,"name":"Azgp1","annotation":"Zinc-alpha-2-glycoprotein; Stimulates lipid degradation in adipocytes and causes the extensive fat losses associated with some advanced cancers."},{"id":"ENSMUSP00000072387","abundance":31.5,"rank":2147,"name":"Ube2d2b","annotation":"Ubiquitin-conjugating enzyme E2 D2B; Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection (By similarity [...] "},{"id":"ENSMUSP00000073778","abundance":31.5,"rank":2148,"name":"Dcaf8","annotation":"DDB1- and CUL4-associated factor 8; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF8 family."},{"id":"ENSMUSP00000134823","abundance":31.5,"rank":2149,"name":"Cpsf6","annotation":"Cleavage and polyadenylation specificity factor subunit 6; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The  [...] "},{"id":"ENSMUSP00000082459","abundance":31.4,"rank":2150,"name":"Hrc","annotation":"Histidine-rich calcium-binding protein."},{"id":"ENSMUSP00000033642","abundance":31.4,"rank":2151,"name":"Dcx","annotation":"Neuronal migration protein doublecortin; Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration."},{"id":"ENSMUSP00000071084","abundance":31.4,"rank":2152,"name":"Mobp","annotation":"Myelin-associated oligodendrocyte basic protein; May play a role in compacting or stabilizing the myelin sheath possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane."},{"id":"ENSMUSP00000074990","abundance":31.4,"rank":2153,"name":"Cyp2a12","annotation":"Cytochrome P450 2A12; Highly active in the 7-alpha-hydroxylation of testosterone."},{"id":"ENSMUSP00000104939","abundance":31.4,"rank":2154,"name":"Pltp","annotation":"Phospholipid transfer protein; Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that [...] "},{"id":"ENSMUSP00000077019","abundance":31.3,"rank":2155,"name":"Prpf4b","annotation":"Serine/threonine-protein kinase PRP4 homolog; Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family."},{"id":"ENSMUSP00000059101","abundance":31.3,"rank":2156,"name":"Gm5414","annotation":"Type II keratin Kb14; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000107914","abundance":31.3,"rank":2157,"name":"Gmppb","annotation":"Mannose-1-phosphate guanyltransferase beta; Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids."},{"id":"ENSMUSP00000072087","abundance":31.3,"rank":2158,"name":"Tmod3","annotation":"Tropomodulin-3; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity); Belongs to the tropomodulin family."},{"id":"ENSMUSP00000003572","abundance":31.2,"rank":2159,"name":"Gars","annotation":"Glycine--tRNA ligase; Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis."},{"id":"ENSMUSP00000001240","abundance":31.2,"rank":2160,"name":"Agpat3","annotation":"1-acyl-sn-glycerol-3-phosphate acyltransferase gamma; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA (By similarity). Has a preference for arachidon [...] "},{"id":"ENSMUSP00000022960","abundance":31.2,"rank":2161,"name":"Eif3e","annotation":"Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] "},{"id":"ENSMUSP00000057595","abundance":31.2,"rank":2162,"name":"Slc27a2","annotation":"Very long-chain acyl-CoA synthetase; Acyl CoA synthetase that activates long-chain and very long- chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl- CoA. Can also activate branched- chain fatty acids such as phytanic acid and pristanic acid (By similarity). Does not activate C24 bile acids, cholate and chenodeoxycholate (By similarity). In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy- 5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (By similarity). Exhibits long-chain fatty acids (LCFA) transp [...] "},{"id":"ENSMUSP00000040150","abundance":31.2,"rank":2163,"name":"Fhl3","annotation":"Four and a half LIM domains protein 3; Recruited by SOX15 to FOXK1 promoters where it acts as a transcriptional coactivator of FOXK1."},{"id":"ENSMUSP00000017867","abundance":31.2,"rank":2164,"name":"Wfdc2","annotation":"WAP four-disulfide core domain protein 2; Broad range protease inhibitor."},{"id":"ENSMUSP00000112638","abundance":31.2,"rank":2165,"name":"Pef1","annotation":"Peflin; Calcium-binding protein that acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium. Together with PDCD6, acts as calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in endoplasmic reticulum (ER)-Golgi transport by regulating the size of COPII coats. In response to cytosolic calcium increase, the heterodimer formed with PDCD6 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is  [...] "},{"id":"ENSMUSP00000080462","abundance":31.2,"rank":2166,"name":"Edil3","annotation":"EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development."},{"id":"ENSMUSP00000026210","abundance":31.1,"rank":2167,"name":"Cpn1","annotation":"Carboxypeptidase N catalytic chain; Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation; Belongs to the peptidase M14 family."},{"id":"ENSMUSP00000099599","abundance":31.1,"rank":2168,"name":"Gale","annotation":"UDP-glucose 4-epimerase; Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversi [...] "},{"id":"ENSMUSP00000055803","abundance":31.1,"rank":2169,"name":"Glb1","annotation":"Beta-galactosidase; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Belongs to the glycosyl hydrolase 35 family."},{"id":"ENSMUSP00000043041","abundance":31.1,"rank":2170,"name":"Abhd11","annotation":"Protein ABHD11; Belongs to the AB hydrolase superfamily."},{"id":"ENSMUSP00000092233","abundance":31.1,"rank":2171,"name":"Ugt2b36","annotation":"UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000158375","abundance":31.1,"rank":2172,"name":"Txnl1","annotation":"Thioredoxin-like protein 1; Active thioredoxin with a redox potential of about -250 mV."},{"id":"ENSMUSP00000021443","abundance":31,"rank":2173,"name":"Mthfd1","annotation":"C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed; In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family."},{"id":"ENSMUSP00000104725","abundance":31,"rank":2174,"name":"Sec24a","annotation":"Protein transport protein Sec24A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may [...] "},{"id":"ENSMUSP00000004134","abundance":31,"rank":2175,"name":"Gstm5","annotation":"Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family."},{"id":"ENSMUSP00000101980","abundance":31,"rank":2176,"name":"Sult1a1","annotation":"Sulfotransferase 1A1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (By similarity)."},{"id":"ENSMUSP00000004206","abundance":31,"rank":2177,"name":"Eif3g","annotation":"Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] "},{"id":"ENSMUSP00000041968","abundance":31,"rank":2178,"name":"Psmd7","annotation":"26S proteasome non-ATPase regulatory subunit 7; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the peptidase M67A family."},{"id":"ENSMUSP00000039493","abundance":31,"rank":2179,"name":"Arglu1","annotation":"Arginine and glutamate-rich protein 1."},{"id":"ENSMUSP00000041503","abundance":30.9,"rank":2180,"name":"Arl6ip5","annotation":"PRA1 family protein 3; Regulates intracellular concentrations of taurine and glutamate (By similarity). Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic (By similarity)."},{"id":"ENSMUSP00000048334","abundance":30.9,"rank":2181,"name":"Fbln2","annotation":"Fibulin-2; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN; Belongs to the fibulin family."},{"id":"ENSMUSP00000035078","abundance":30.8,"rank":2182,"name":"Lrrfip2","annotation":"Leucine-rich repeat flightless-interacting protein 2; May function as activator of the canonical Wnt signaling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity)."},{"id":"ENSMUSP00000002735","abundance":30.8,"rank":2183,"name":"Clpp","annotation":"ATP-dependent Clp protease proteolytic subunit, mitochondrial; Protease component of the Clp complex that cleaves peptides and various proteins in an ATP-dependent process. Has low peptidase activity in the absence of CLPX. The Clp complex can degrade CSN1S1, CSN2 and CSN3, as well as synthetic peptides (in vitro) and may be responsible for a fairly general and central housekeeping function rather than for the degradation of specific substrates. Cleaves PINK1 in the mitochondrion."},{"id":"ENSMUSP00000105210","abundance":30.8,"rank":2184,"name":"Ces1b","annotation":"Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000069318","abundance":30.8,"rank":2185,"name":"Cpn2","annotation":"Carboxypeptidase N subunit 2; The 83 kDa subunit binds and stabilizes the catalytic subunit at 37 degrees Celsius and keeps it in circulation. Under some circumstances it may be an allosteric modifier of the catalytic subunit (By similarity)."},{"id":"ENSMUSP00000048667","abundance":30.8,"rank":2186,"name":"F13a1","annotation":"Coagulation factor XIII A chain; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl- epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin."},{"id":"ENSMUSP00000024963","abundance":30.8,"rank":2187,"name":"Mcfd2","annotation":"Multiple coagulation factor deficiency protein 2 homolog; The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins."},{"id":"ENSMUSP00000043203","abundance":30.8,"rank":2188,"name":"Guca2b","annotation":"Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity)."},{"id":"ENSMUSP00000125874","abundance":30.7,"rank":2189,"name":"Ccdc58","annotation":"Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family."},{"id":"ENSMUSP00000064545","abundance":30.7,"rank":2190,"name":"Pdlim1","annotation":"PDZ and LIM domain protein 1; Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts (By similarity)."},{"id":"ENSMUSP00000081232","abundance":30.7,"rank":2191,"name":"Eif4g3","annotation":"Eukaryotic translation initiation factor 4 gamma 3; Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1 (By similarity)."},{"id":"ENSMUSP00000020649","abundance":30.7,"rank":2192,"name":"Rad50","annotation":"DNA repair protein RAD50; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease [...] "},{"id":"ENSMUSP00000026613","abundance":30.7,"rank":2193,"name":"Gusb","annotation":"Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates."},{"id":"ENSMUSP00000109214","abundance":30.6,"rank":2194,"name":"Gmppa","annotation":"Mannose-1-phosphate guanyltransferase alpha; May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose; Belongs to the transferase hexapeptide repeat family."},{"id":"ENSMUSP00000040647","abundance":30.6,"rank":2195,"name":"Wdtc1","annotation":"WD and tetratricopeptide repeats protein 1; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex."},{"id":"ENSMUSP00000119041","abundance":30.6,"rank":2196,"name":"Tnfaip8","annotation":"Tumor necrosis factor alpha-induced protein 8; Acts as a negative mediator of apoptosis. Suppresses the TNF- mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation (By similarity)."},{"id":"ENSMUSP00000102207","abundance":30.5,"rank":2197,"name":"Elavl4","annotation":"ELAV-like protein 4; RNA-binding protein that is involved in the post- transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in the 3' untranslated region (3'UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (By similarity). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function. By binding to the mRNA 3'UTR, decreases mRNA deadenylation and there [...] "},{"id":"ENSMUSP00000108726","abundance":30.5,"rank":2198,"name":"Naaa","annotation":"N-acylethanolamine-hydrolyzing acid amidase subunit alpha; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N- myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine."},{"id":"ENSMUSP00000068318","abundance":30.5,"rank":2199,"name":"Nadk2","annotation":"NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor (By similarity)."},{"id":"ENSMUSP00000050771","abundance":30.5,"rank":2200,"name":"Polr2a","annotation":"DNA-directed RNA polymerase II subunit RPB1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cl [...] "},{"id":"ENSMUSP00000025930","abundance":30.5,"rank":2201,"name":"Smc3","annotation":"Structural maintenance of chromosomes protein 3; Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement; Belongs to the SMC family. SMC3 subfamily."},{"id":"ENSMUSP00000034138","abundance":30.5,"rank":2202,"name":"Dnaja2","annotation":"DnaJ homolog subfamily A member 2; Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)."},{"id":"ENSMUSP00000021285","abundance":30.5,"rank":2203,"name":"Stx8","annotation":"Syntaxin-8; Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis- Golgi membranes to the ER; Belongs to the syntaxin family."},{"id":"ENSMUSP00000028332","abundance":30.4,"rank":2204,"name":"Dpp7","annotation":"Dipeptidyl peptidase 2; Plays an important role in the degradation of some oligopeptides; Belongs to the peptidase S28 family."},{"id":"ENSMUSP00000034264","abundance":30.4,"rank":2205,"name":"Pgls","annotation":"6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily."},{"id":"ENSMUSP00000099807","abundance":30.4,"rank":2206,"name":"Uba2","annotation":"SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity); Belongs to the ubiquitin-activating E1 family."},{"id":"ENSMUSP00000006900","abundance":30.4,"rank":2207,"name":"Acot13","annotation":"Acyl-coenzyme A thioesterase 13; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis."},{"id":"ENSMUSP00000073322","abundance":30.4,"rank":2208,"name":"Rdh1","annotation":"Retinol dehydrogenase 1 (All trans); Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000026723","abundance":30.3,"rank":2209,"name":"Hprt","annotation":"Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity)."},{"id":"ENSMUSP00000022108","abundance":30.3,"rank":2210,"name":"Hapln1","annotation":"Hyaluronan and proteoglycan link protein 1; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix."},{"id":"ENSMUSP00000026452","abundance":30.3,"rank":2211,"name":"Pde6g","annotation":"Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones; Belongs to the rod/cone cGMP-PDE gamma subunit family."},{"id":"ENSMUSP00000025218","abundance":30.3,"rank":2212,"name":"Etf1","annotation":"Eukaryotic peptide chain release factor subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA (By similarity). Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Belongs to the eukaryotic release factor 1 family."},{"id":"ENSMUSP00000050336","abundance":30.3,"rank":2213,"name":"Ckap4","annotation":"Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF."},{"id":"ENSMUSP00000099947","abundance":30.3,"rank":2214,"name":"Ptbp3","annotation":"Polypyrimidine tract-binding protein 3; RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes Fas exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U) (By similarity)."},{"id":"ENSMUSP00000027777","abundance":30.2,"rank":2215,"name":"Parp1","annotation":"Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Mediates the poly(ADP-ribosyl)ation of a number of proteins, including itself, APLF an [...] "},{"id":"ENSMUSP00000101999","abundance":30.2,"rank":2216,"name":"Prpsap1","annotation":"Phosphoribosyl pyrophosphate synthase-associated protein 1; Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis; Belongs to the ribose-phosphate pyrophosphokinase family."},{"id":"ENSMUSP00000124376","abundance":30.2,"rank":2217,"name":"Ctnna2","annotation":"Catenin alpha-2; May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3- mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in th [...] "},{"id":"ENSMUSP00000035177","abundance":30.2,"rank":2218,"name":"Mrpl3","annotation":"39S ribosomal protein L3, mitochondrial; Belongs to the universal ribosomal protein uL3 family."},{"id":"ENSMUSP00000138655","abundance":30.2,"rank":2219,"name":"Anks1b","annotation":"Ankyrin repeat and sterile alpha motif domain-containing protein 1B; Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells."},{"id":"ENSMUSP00000090245","abundance":30.1,"rank":2220,"name":"Marcks","annotation":"Myristoylated alanine-rich C-kinase substrate; MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein."},{"id":"ENSMUSP00000025755","abundance":30.1,"rank":2221,"name":"Dmrt1","annotation":"Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and prom [...] "},{"id":"ENSMUSP00000010007","abundance":30.1,"rank":2222,"name":"Sdhb","annotation":"Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)."},{"id":"ENSMUSP00000042134","abundance":30,"rank":2223,"name":"Tsfm","annotation":"Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family."},{"id":"ENSMUSP00000045606","abundance":30,"rank":2224,"name":"Hibch","annotation":"3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity); Belongs to the enoyl-CoA hydratase/isomerase family."},{"id":"ENSMUSP00000022060","abundance":30,"rank":2225,"name":"Pdcd6","annotation":"Programmed cell death protein 6; Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes. Involved in ER- Golgi transport by promoting the association between PDCD6IP and TSG101, thereby  [...] "},{"id":"ENSMUSP00000073697","abundance":30,"rank":2226,"name":"Sap18b","annotation":"Histone deacetylase complex subunit SAP18; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or durin [...] "},{"id":"ENSMUSP00000120071","abundance":30,"rank":2227,"name":"Sap18","annotation":"Sin3-associated polypeptide 18."},{"id":"ENSMUSP00000153147","abundance":30,"rank":2228,"name":"Mbl1","annotation":"Mannose-binding protein A; Calcium-dependent lectin. Plays a role in the innate immune response by binding mannose, fucose and N-acetylglucosamine moieties on different microorganisms and mediating activation of the lectin complement pathway (By similarity). Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity)."},{"id":"ENSMUSP00000031398","abundance":29.9,"rank":2229,"name":"Hpd","annotation":"4-hydroxyphenylpyruvate dioxygenase; Key enzyme in the degradation of tyrosine; Belongs to the 4HPPD family."},{"id":"ENSMUSP00000108764","abundance":29.9,"rank":2230,"name":"Ugt1a8","annotation":"UDP-glucuronosyltransferase 1-7C; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols."},{"id":"ENSMUSP00000018399","abundance":29.9,"rank":2231,"name":"Krt33a","annotation":"Keratin, type I cuticular Ha3-I."},{"id":"ENSMUSP00000081943","abundance":29.9,"rank":2232,"name":"Crip2","annotation":"Cysteine-rich protein 2."},{"id":"ENSMUSP00000036044","abundance":29.9,"rank":2233,"name":"Apob","annotation":"Apolipoprotein B-100; Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B- 100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor."},{"id":"ENSMUSP00000049902","abundance":29.9,"rank":2234,"name":"Trim2","annotation":"Tripartite motif-containing protein 2; UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance."},{"id":"ENSMUSP00000127851","abundance":29.9,"rank":2235,"name":"Pafah1b2","annotation":"Platelet-activating factor acetylhydrolase IB subunit beta; Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit; Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily."},{"id":"ENSMUSP00000002572","abundance":29.9,"rank":2236,"name":"Slc9a3r2","annotation":"Na(+)/H(+) exchange regulatory cofactor NHE-RF2; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus (By similarity)."},{"id":"ENSMUSP00000099422","abundance":29.9,"rank":2237,"name":"Smarce1","annotation":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). Du [...] "},{"id":"ENSMUSP00000147674","abundance":29.9,"rank":2238,"name":"Bpnt1","annotation":"3'(2'),5'-bisphosphate nucleotidase 1; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6; Belongs to the inositol monophosphatase superfamily."},{"id":"ENSMUSP00000032888","abundance":29.8,"rank":2239,"name":"Arl6ip1","annotation":"ADP-ribosylation factor-like protein 6-interacting protein 1; Positively regulates SLC1A1/EAAC1-mediated glutamate transport by increasing its affinity for glutamate in a PKC activity- dependent manner. Promotes the catalytic efficiency of SLC1A1/EAAC1 probably by reducing its interaction with ARL6IP5, a negative regulator of SLC1A1/EAAC1-mediated glutamate transport. Plays a role in the formation and stabilization of endoplasmic reticulum tubules. Negatively regulates apoptosis, possibly by modulating the activity of caspase-9 (CASP9). Inhibits cleavage of CASP9-dependent substrates a [...] "},{"id":"ENSMUSP00000050036","abundance":29.8,"rank":2240,"name":"Cnrip1","annotation":"CB1 cannabinoid receptor-interacting protein 1; Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels."},{"id":"ENSMUSP00000021628","abundance":29.8,"rank":2241,"name":"Akr1c21","annotation":"Aldo-keto reductase family 1 member C21; NADP-dependent 17-alpha-hydroxysteroid dehydrogenase that converts 5-alpha-androstane-3,17-dione into androsterone. Has lower 3- alpha-hydroxysteroid dehydrogenase activity. Has broad substrate specificity and acts on various 17-alpha-hydroxysteroids, 17- ketosteroids, 3-alpha hydroxysteroids and 3-ketosteroids. Reduction of keto groups is strictly stereoselective. Reduction of 17-ketosteroids yields only 17-alpha-hydroxysteroids. Likewise, reduction of 3- ketosteroids yields only 3-alpha-hydroxysteroids. Belongs to the aldo/keto reductase family."},{"id":"ENSMUSP00000073072","abundance":29.8,"rank":2242,"name":"Ctse","annotation":"Cathepsin E; May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain; Belongs to the peptidase A1 family."},{"id":"ENSMUSP00000078602","abundance":29.8,"rank":2243,"name":"U2surp","annotation":"U2 snRNP-associated SURP motif-containing protein."},{"id":"ENSMUSP00000148700","abundance":29.8,"rank":2244,"name":"Nup93","annotation":"Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC (By similarity). During renal development, regulates podocyte migration and proliferation through SMAD4 signaling (By similarity) ; Belongs to the nucleoporin interacting component (NIC) family."},{"id":"ENSMUSP00000070588","abundance":29.8,"rank":2245,"name":"Rab13","annotation":"Ras-related protein Rab-13; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regu [...] "},{"id":"ENSMUSP00000039684","abundance":29.8,"rank":2246,"name":"Gm5771","annotation":"Predicted gene, EG436523; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000099953","abundance":29.8,"rank":2247,"name":"Ecpas","annotation":"Proteasome adapter and scaffold protein ECM29; Adapter/scaffolding protein that binds to the 26S proteasome, motor proteins and other compartment specific proteins. May couple the proteasome to different compartments including endosome, endoplasmic reticulum and centrosome. May play a role in ERAD and other enhanced proteolysis (By similarity). Promotes proteasome dissociation under oxidative stress ; Belongs to the ECM29 family."},{"id":"ENSMUSP00000077693","abundance":29.8,"rank":2248,"name":"Cryba1","annotation":"Beta-crystallin A1; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000038540","abundance":29.8,"rank":2249,"name":"Pdxk","annotation":"Pyridoxal kinase; Required for synthesis of pyridoxal-5-phosphate from vitamin B6."},{"id":"ENSMUSP00000102395","abundance":29.7,"rank":2250,"name":"Timm10b","annotation":"Mitochondrial import inner membrane translocase subunit Tim10 B; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space."},{"id":"ENSMUSP00000148176","abundance":29.7,"rank":2251,"name":"Gm45799","annotation":"Predicted gene 45799."},{"id":"ENSMUSP00000126268","abundance":29.7,"rank":2252,"name":"Kars","annotation":"Lysine--tRNA ligase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity; Belongs to the class-I [...] "},{"id":"ENSMUSP00000028553","abundance":29.7,"rank":2253,"name":"Nop10","annotation":"H/ACA ribonucleoprotein complex subunit 3; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] "},{"id":"ENSMUSP00000035116","abundance":29.7,"rank":2254,"name":"Pccb","annotation":"Propionyl-CoA carboxylase beta chain, mitochondrial; This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl- CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carr [...] "},{"id":"ENSMUSP00000004232","abundance":29.7,"rank":2255,"name":"Adh1","annotation":"Alcohol dehydrogenase 1; Belongs to the zinc-containing alcohol dehydrogenase family. Class-I subfamily."},{"id":"ENSMUSP00000021668","abundance":29.7,"rank":2256,"name":"Npc2","annotation":"NPC intracellular cholesterol transporter 2; Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. May bind and mobilize cholesterol that is associated with membranes. NPC2 binds cholesterol with a 1:1 stoichiometry. Can bind a variety of sterols, including lathosterol, desmosterol and the pl [...] "},{"id":"ENSMUSP00000035055","abundance":29.6,"rank":2257,"name":"Map4","annotation":"Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly."},{"id":"ENSMUSP00000075690","abundance":29.6,"rank":2258,"name":"Serpinb1a","annotation":"Leukocyte elastase inhibitor A; Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as  [...] "},{"id":"ENSMUSP00000025045","abundance":29.6,"rank":2259,"name":"Uqcc2","annotation":"Ubiquinol-cytochrome-c reductase complex assembly factor 2; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Plays a role in the modulation of respiratory chain activities such as oxygen consumption and ATP production and via its modulation of the respiratory chain activity can regulate skeletal muscle differentiation and insulin secretion by pancreatic beta-cells. Involved in cytochrome b translation and/or stability."},{"id":"ENSMUSP00000127193","abundance":29.6,"rank":2260,"name":"Mapk10","annotation":"Mitogen-activated protein kinase 10; Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF [...] "},{"id":"ENSMUSP00000001181","abundance":29.6,"rank":2261,"name":"Col6a2","annotation":"Collagen alpha-2(VI) chain; Collagen VI acts as a cell-binding protein."},{"id":"ENSMUSP00000027726","abundance":29.5,"rank":2262,"name":"Cyb5r1","annotation":"NADH-cytochrome b5 reductase 1; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction."},{"id":"ENSMUSP00000095322","abundance":29.5,"rank":2263,"name":"Mrpl43","annotation":"39S ribosomal protein L43, mitochondrial."},{"id":"ENSMUSP00000046506","abundance":29.5,"rank":2264,"name":"Rpl37","annotation":"60S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family."},{"id":"ENSMUSP00000013304","abundance":29.5,"rank":2265,"name":"Atp6v0d1","annotation":"V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the acti [...] "},{"id":"ENSMUSP00000033875","abundance":29.5,"rank":2266,"name":"Plpbp","annotation":"Pyridoxal phosphate homeostasis protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'- phosphate (PLP), the active form of vitamin B6."},{"id":"ENSMUSP00000135394","abundance":29.5,"rank":2267,"name":"Esd","annotation":"S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde."},{"id":"ENSMUSP00000058567","abundance":29.5,"rank":2268,"name":"Ces2c","annotation":"Acylcarnitine hydrolase; Hydrolase with high activity towards palmitoylcarnitine. Is also active with p-nitrophenylacetate and alpha-naphthylacetate. Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000139967","abundance":29.5,"rank":2269,"name":"Gm4450","annotation":"Predicted gene 4450."},{"id":"ENSMUSP00000109291","abundance":29.4,"rank":2270,"name":"Kyat1","annotation":"Kynurenine--oxoglutarate transaminase 1; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family."},{"id":"ENSMUSP00000103015","abundance":29.4,"rank":2271,"name":"Anpep","annotation":"Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines (By similarity). May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization (By similarity). May have a role in amino aci [...] "},{"id":"ENSMUSP00000034929","abundance":29.4,"rank":2272,"name":"Lactb","annotation":"Serine beta-lactamase-like protein LACTB, mitochondrial; Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (By similarity). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (By similarity). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (By similarity). Acts as a tumor suppressor that has the ability to inhibit proli [...] "},{"id":"ENSMUSP00000140250","abundance":29.4,"rank":2273,"name":"Nop58","annotation":"Nucleolar protein 58; Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (By similarity). Belongs to the NOP5/NOP56 family."},{"id":"ENSMUSP00000105264","abundance":29.4,"rank":2274,"name":"Uqcc1","annotation":"Ubiquinol-cytochrome-c reductase complex assembly factor 1; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability."},{"id":"ENSMUSP00000022858","abundance":29.4,"rank":2275,"name":"Agxt2","annotation":"Alanine--glyoxylate aminotransferase 2, mitochondrial; Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure."},{"id":"ENSMUSP00000036304","abundance":29.4,"rank":2276,"name":"Lpp","annotation":"Lipoma-preferred partner homolog; May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus (By similarity)."},{"id":"ENSMUSP00000068610","abundance":29.4,"rank":2277,"name":"Emc7","annotation":"ER membrane protein complex subunit 7; Belongs to the EMC7 family."},{"id":"ENSMUSP00000015391","abundance":29.4,"rank":2278,"name":"Nipsnap3b","annotation":"Protein NipSnap homolog 3B."},{"id":"ENSMUSP00000002198","abundance":29.4,"rank":2279,"name":"Sf3a1","annotation":"Splicing factor 3A subunit 1; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes."},{"id":"ENSMUSP00000032963","abundance":29.3,"rank":2280,"name":"Ppme1","annotation":"Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity)."},{"id":"ENSMUSP00000113840","abundance":29.3,"rank":2281,"name":"Lmo4","annotation":"LIM domain transcription factor LMO4; Probable transcriptional factor."},{"id":"ENSMUSP00000031355","abundance":29.2,"rank":2282,"name":"Uso1","annotation":"General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity; Belongs to the VDP/USO1/EDE1 family."},{"id":"ENSMUSP00000006912","abundance":29.2,"rank":2283,"name":"Pip4k2a","annotation":"Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of [...] "},{"id":"ENSMUSP00000006181","abundance":29.2,"rank":2284,"name":"Napa","annotation":"Alpha-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. Together with GNA12 promotes CDH5 localization to plasma membrane."},{"id":"ENSMUSP00000025229","abundance":29.1,"rank":2285,"name":"Cfb","annotation":"Complement factor B Ba fragment; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase."},{"id":"ENSMUSP00000093831","abundance":29.1,"rank":2286,"name":"Cstf2t","annotation":"Cleavage stimulation factor subunit 2 tau variant; May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre- mRNAs."},{"id":"ENSMUSP00000108302","abundance":29.1,"rank":2287,"name":"Slc25a18","annotation":"Mitochondrial glutamate carrier 2; Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H(+) (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000062049","abundance":29.1,"rank":2288,"name":"Cit","annotation":"Citron Rho-interacting kinase; Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Probable RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2."},{"id":"ENSMUSP00000021822","abundance":29.1,"rank":2289,"name":"Ogn","annotation":"Mimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily."},{"id":"ENSMUSP00000076503","abundance":29.1,"rank":2290,"name":"Gfm1","annotation":"Elongation factor G, mitochondrial; Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mito [...] "},{"id":"ENSMUSP00000039663","abundance":29.1,"rank":2291,"name":"Dmgdh","annotation":"Dimethylglycine dehydrogenase, mitochondrial; Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro."},{"id":"ENSMUSP00000031627","abundance":29,"rank":2292,"name":"Pdap1","annotation":"28 kDa heat- and acid-stable phosphoprotein."},{"id":"ENSMUSP00000030404","abundance":29,"rank":2293,"name":"Ppie","annotation":"Peptidyl-prolyl cis-trans isomerase E; Involved in pre-mRNA splicing as component of the spliceosome. Combines RNA-binding and PPIase activities. Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'- UTR of mRNA molecules. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. Inhibits KMT2A activity; this requires proline isomerase activity."},{"id":"ENSMUSP00000005019","abundance":29,"rank":2294,"name":"Crabp2","annotation":"Cellular retinoic acid-binding protein 2; Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors."},{"id":"ENSMUSP00000112213","abundance":29,"rank":2295,"name":"Wbp11","annotation":"WW domain-binding protein 11; Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity."},{"id":"ENSMUSP00000024755","abundance":28.9,"rank":2296,"name":"Clic5","annotation":"Chloride intracellular channel protein 5; Required for normal hearing (By similarity). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal [...] "},{"id":"ENSMUSP00000111560","abundance":28.9,"rank":2297,"name":"Uba1y","annotation":"Ubiquitin-like modifier-activating enzyme 1 Y; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (By similarity). The Y chromosome form could be involved in the survival and proliferation of differentiating spermatogonia."},{"id":"ENSMUSP00000020343","abundance":28.9,"rank":2298,"name":"Rab21","annotation":"Ras-related protein Rab-21; Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediate [...] "},{"id":"ENSMUSP00000047864","abundance":28.8,"rank":2299,"name":"Sun2","annotation":"SUN domain-containing protein 2; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-depend [...] "},{"id":"ENSMUSP00000085906","abundance":28.8,"rank":2300,"name":"Fmr1","annotation":"Synaptic functional regulator FMR1; Multifunctional polyribosome-associated RNA-binding protein that plays a central role in neuronal development and synaptic plasticity through the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs. Plays a role in the alternative splicing of its own mRNA. Plays a role in mRNA nuclear export. Together with export factor NXF2, is involved in the regulation of the NXF1 mRNA stability in neurons. Stabilizes the scaffolding postsynaptic density protein DLG4/PSD-95 [...] "},{"id":"ENSMUSP00000017732","abundance":28.8,"rank":2301,"name":"Krt27","annotation":"Keratin, type I cytoskeletal 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs)."},{"id":"ENSMUSP00000099935","abundance":28.8,"rank":2302,"name":"L1cam","annotation":"Neural cell adhesion molecule L1; Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity."},{"id":"ENSMUSP00000030702","abundance":28.7,"rank":2303,"name":"Ppp1r8","annotation":"Nuclear inhibitor of protein phosphatase 1; Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre- mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development."},{"id":"ENSMUSP00000015011","abundance":28.7,"rank":2304,"name":"Surf4","annotation":"Surfeit locus protein 4; May play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi. Belongs to the SURF4 family."},{"id":"ENSMUSP00000113431","abundance":28.7,"rank":2305,"name":"Rsl1d1","annotation":"Ribosomal L1 domain-containing protein 1; Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage."},{"id":"ENSMUSP00000101921","abundance":28.7,"rank":2306,"name":"Sept1","annotation":"Septin-1; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)."},{"id":"ENSMUSP00000058846","abundance":28.7,"rank":2307,"name":"Aph1a","annotation":"Gamma-secretase subunit APH-1A; Non-catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Required for normal gamma-secretase assembly. The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable)."},{"id":"ENSMUSP00000122090","abundance":28.7,"rank":2308,"name":"Snapin","annotation":"SNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate [...] "},{"id":"ENSMUSP00000029698","abundance":28.7,"rank":2309,"name":"Lamtor2","annotation":"Ragulator complex protein LAMTOR2; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] "},{"id":"ENSMUSP00000047326","abundance":28.6,"rank":2310,"name":"Actr1b","annotation":"Beta-centractin; Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome (By similarity); Belongs to the actin family. ARP1 subfamily."},{"id":"ENSMUSP00000023826","abundance":28.6,"rank":2311,"name":"Sncg","annotation":"Gamma-synuclein; Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity)."},{"id":"ENSMUSP00000031668","abundance":28.6,"rank":2312,"name":"Col1a2","annotation":"Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family."},{"id":"ENSMUSP00000042691","abundance":28.6,"rank":2313,"name":"Ddx21","annotation":"Nucleolar RNA helicase 2; RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (By similarity). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (By similarity). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification (By similarity). Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNOR [...] "},{"id":"ENSMUSP00000122366","abundance":28.5,"rank":2314,"name":"Dad1","annotation":"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] "},{"id":"ENSMUSP00000003100","abundance":28.5,"rank":2315,"name":"Cyp2f2","annotation":"Cytochrome P450 2F2; Involved in the regio- and stereoselective transformation of naphthalene to trans-1R-hydroxy-2R-glutathionyl-1,2-dihydronaphthalene in the presence of glutathione and glutathione S-transferases. It specifically catalyzes the production of a very reactive and potentially toxic intermediate, the 2R,2S arene oxide, that is associated with necrosis of the unciliated bronchiolar epithelial cells or Clara cells in lung; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000088964","abundance":28.5,"rank":2316,"name":"Arsb","annotation":"Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family."},{"id":"ENSMUSP00000040877","abundance":28.5,"rank":2317,"name":"Lum","annotation":"Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily."},{"id":"ENSMUSP00000029382","abundance":28.5,"rank":2318,"name":"Ppid","annotation":"Peptidyl-prolyl cis-trans isomerase D; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor co [...] "},{"id":"ENSMUSP00000123765","abundance":28.5,"rank":2319,"name":"Sucla2","annotation":"Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit."},{"id":"ENSMUSP00000125415","abundance":28.5,"rank":2320,"name":"Mob4","annotation":"MOB-like protein phocein; May play a role in membrane trafficking, specifically in membrane budding reactions; Belongs to the MOB1/phocein family."},{"id":"ENSMUSP00000026973","abundance":28.4,"rank":2321,"name":"Prkar1b","annotation":"cAMP-dependent protein kinase type I-beta regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells."},{"id":"ENSMUSP00000030192","abundance":28.4,"rank":2322,"name":"Hint2","annotation":"Histidine triad nucleotide-binding protein 2, mitochondrial; Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity); Belongs to the HINT family."},{"id":"ENSMUSP00000039134","abundance":28.4,"rank":2323,"name":"Edc4","annotation":"Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping. Component of a complex containing DCP2 and DCP1A which functions in decapping of ARE-containing mRNAs. Promotes complex formation between DCP1A and DCP2. Enhances the catalytic activity of DCP2 (in vitro)."},{"id":"ENSMUSP00000001569","abundance":28.4,"rank":2324,"name":"Flot1","annotation":"Flotillin-1; May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles."},{"id":"ENSMUSP00000006626","abundance":28.4,"rank":2325,"name":"Actn3","annotation":"Alpha-actinin-3; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity); Belongs to the alpha-actinin family."},{"id":"ENSMUSP00000045208","abundance":28.4,"rank":2326,"name":"Uchl4","annotation":"Ubiquitin carboxyl-terminal hydrolase isozyme L4; Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin; Belongs to the peptidase C12 family."},{"id":"ENSMUSP00000083620","abundance":28.4,"rank":2327,"name":"Col5a2","annotation":"Collagen alpha-2(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices."},{"id":"ENSMUSP00000079065","abundance":28.4,"rank":2328,"name":"Cyp2c50","annotation":"Cytochrome P450 2C50; Metabolizes arachidonic acid to several midchain and omega- terminal hydroxyeicosatetraenoic acids (HETE)."},{"id":"ENSMUSP00000025979","abundance":28.4,"rank":2329,"name":"Aldh18a1","annotation":"Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family."},{"id":"ENSMUSP00000021458","abundance":28.3,"rank":2330,"name":"Sptb","annotation":"Spectrin beta chain, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane."},{"id":"ENSMUSP00000026985","abundance":28.3,"rank":2331,"name":"Cplx2","annotation":"Complexin-2; Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis. Although not essential for development, seems critical for the acquisition of higher cognitive functions in the adult brain. Belongs to the complexin/synaphin family."},{"id":"ENSMUSP00000062392","abundance":28.3,"rank":2332,"name":"Prkca","annotation":"Protein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] "},{"id":"ENSMUSP00000026387","abundance":28.2,"rank":2333,"name":"Sbds","annotation":"Ribosome maturation protein SBDS; Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell prolifer [...] "},{"id":"ENSMUSP00000128943","abundance":28.2,"rank":2334,"name":"Prg4","annotation":"Proteoglycan 4 C-terminal part; Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface."},{"id":"ENSMUSP00000008991","abundance":28.2,"rank":2335,"name":"Sptbn2","annotation":"Spectrin beta chain; Belongs to the spectrin family."},{"id":"ENSMUSP00000026009","abundance":28.2,"rank":2336,"name":"Arl3","annotation":"ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Requires assistance from GTPase-activating prote [...] "},{"id":"ENSMUSP00000109251","abundance":28.2,"rank":2337,"name":"Sh3glb2","annotation":"Endophilin-B2."},{"id":"ENSMUSP00000136524","abundance":28.2,"rank":2338,"name":"Lmnb2","annotation":"Lamin-B2; Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin."},{"id":"ENSMUSP00000030734","abundance":28.1,"rank":2339,"name":"Sf3a3","annotation":"Splicing factor 3A subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes."},{"id":"ENSMUSP00000032165","abundance":28.1,"rank":2340,"name":"Ruvbl1","annotation":"RuvB-like 1; Possesses single-stranded DNA-stimulated ATPase and ATP- dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring- like structure contribute to the ATPase activity (By similarity). Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with oth [...] "},{"id":"ENSMUSP00000095534","abundance":28.1,"rank":2341,"name":"Cdkn2c","annotation":"Cyclin-dependent kinase 4 inhibitor C; Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB; Belongs to the CDKN2 cyclin-dependent kinase inhibitor family."},{"id":"ENSMUSP00000025408","abundance":28,"rank":2342,"name":"Afg3l2","annotation":"AFG3-like protein 2; ATP-dependent protease which is essential for axonal and neuron development. In neurons, mediates degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU (By similarity). Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mito [...] "},{"id":"ENSMUSP00000134673","abundance":28,"rank":2343,"name":"Csnk2b","annotation":"Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). Participates in Wnt signaling; Belongs to the casein kinase 2 subunit beta family."},{"id":"ENSMUSP00000020930","abundance":28,"rank":2344,"name":"Gna13","annotation":"Guanine nucleotide-binding protein subunit alpha-13; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG). GNA13- dependent Rho signaling subsequently regulates transcription factor AP- 1 (activating protein-1). Promotes tumor cell invasion and metastasis by activating Rho/ROCK signaling pathway (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho  [...] "},{"id":"ENSMUSP00000078940","abundance":28,"rank":2345,"name":"Gspt1","annotation":"Eukaryotic peptide chain release factor GTP-binding subunit ERF3A; Involved in translation termination in response to the termination codons UAA, UAG and UGA (By similarity). Stimulates the activity of ETF1 (By similarity). Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses a [...] "},{"id":"ENSMUSP00000140170","abundance":28,"rank":2346,"name":"Agfg1","annotation":"Arf-GAP domain and FG repeat-containing protein 1; Required for vesicle docking or fusion during acrosome biogenesis. May play a role in RNA trafficking or localization."},{"id":"ENSMUSP00000124305","abundance":28,"rank":2347,"name":"Selenop","annotation":"Selenoprotein P; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium (By similarity). May supply selenium to tissues such as brain and testis."},{"id":"ENSMUSP00000114351","abundance":28,"rank":2348,"name":"Tcp10a","annotation":"T-complex protein 10a."},{"id":"ENSMUSP00000112365","abundance":28,"rank":2349,"name":"Tcp10b","annotation":"T-complex protein 10b."},{"id":"ENSMUSP00000044903","abundance":28,"rank":2350,"name":"Thbs1","annotation":"Thrombospondin-1; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp. Ligand for CD36 mediating antiangiogenic properties (By similarity). Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors."},{"id":"ENSMUSP00000131243","abundance":28,"rank":2351,"name":"Ppt2","annotation":"Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S-thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins (By similarity)."},{"id":"ENSMUSP00000039784","abundance":27.9,"rank":2352,"name":"Mrpl23","annotation":"39S ribosomal protein L23, mitochondrial; Belongs to the universal ribosomal protein uL23 family."},{"id":"ENSMUSP00000026540","abundance":27.9,"rank":2353,"name":"Prap1","annotation":"Proline-rich acidic protein 1; May play an important role in maintaining normal growth homeostasis in epithelial cells."},{"id":"ENSMUSP00000020779","abundance":27.9,"rank":2354,"name":"Mpo","annotation":"Myeloperoxidase heavy chain; Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity; Belongs to the peroxidase family. XPO subfamily."},{"id":"ENSMUSP00000099787","abundance":27.9,"rank":2355,"name":"Cobll1","annotation":"Cordon-bleu protein-like 1."},{"id":"ENSMUSP00000110771","abundance":27.9,"rank":2356,"name":"Cul4b","annotation":"Cullin-4B; Core component of multiple cullin-RING-based E3 ubiquitin- protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and  [...] "},{"id":"ENSMUSP00000032172","abundance":27.8,"rank":2357,"name":"Chchd6","annotation":"MICOS complex subunit Mic25; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane."},{"id":"ENSMUSP00000099650","abundance":27.8,"rank":2358,"name":"Kpna6","annotation":"Importin subunit alpha-7; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] "},{"id":"ENSMUSP00000037131","abundance":27.8,"rank":2359,"name":"Gcsh","annotation":"Glycine cleavage system H protein, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST) (By similarity). Belongs to the GcvH family."},{"id":"ENSMUSP00000003137","abundance":27.8,"rank":2360,"name":"Cyp2c29","annotation":"Cytochrome P450 2C29; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET)."},{"id":"ENSMUSP00000036962","abundance":27.8,"rank":2361,"name":"Clstn1","annotation":"Soluble Alc-alpha; Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. As intracellular fragment AlcICD, suppresses APBB1-dependent tran [...] "},{"id":"ENSMUSP00000070019","abundance":27.8,"rank":2362,"name":"Prkcb","annotation":"Protein kinase C beta type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR- induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser- [...] "},{"id":"ENSMUSP00000046910","abundance":27.7,"rank":2363,"name":"Selenof","annotation":"Selenoprotein F; May be involved in redox reactions associated with the formation of disulfide bonds (By similarity). May contribute to the quality control of protein folding in the endoplasmic reticulum. May regulate protein folding by enhancing the catalytic activity of UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity)."},{"id":"ENSMUSP00000103557","abundance":27.7,"rank":2364,"name":"Selenot","annotation":"Thioredoxin reductase-like selenoprotein T; Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress ans cell death. Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation. In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prol [...] "},{"id":"ENSMUSP00000096397","abundance":27.7,"rank":2365,"name":"Ehd2","annotation":"EH domain-containing protein 2; ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (By similarity)."},{"id":"ENSMUSP00000111150","abundance":27.7,"rank":2366,"name":"Raver1","annotation":"Ribonucleoprotein PTB-binding 1; Cooperates with PTBP1 to modulate regulated alternative splicing events. Promotes exon skipping. Cooperates with PTBP1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA."},{"id":"ENSMUSP00000027623","abundance":27.6,"rank":2367,"name":"Tsn","annotation":"Translin; DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots. Belongs to the translin family."},{"id":"ENSMUSP00000151638","abundance":27.6,"rank":2368,"name":"Stx7","annotation":"Syntaxin-7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity)."},{"id":"ENSMUSP00000034141","abundance":27.6,"rank":2369,"name":"Lonp2","annotation":"Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1."},{"id":"ENSMUSP00000114458","abundance":27.6,"rank":2370,"name":"Arl4a","annotation":"ADP-ribosylation factor-like protein 4A; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form (By similarity)."},{"id":"ENSMUSP00000143312","abundance":27.6,"rank":2371,"name":"Sh3glb1","annotation":"Endophilin-B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation. Isoform 1 acts proapoptotic in fibroblasts. Involved in caspase- independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with [...] "},{"id":"ENSMUSP00000035851","abundance":27.6,"rank":2372,"name":"Nploc4","annotation":"Nuclear protein localization protein 4 homolog; The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination [...] "},{"id":"ENSMUSP00000029178","abundance":27.6,"rank":2373,"name":"Ctnnbl1","annotation":"Beta-catenin-like protein 1; Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May induce apoptosis (By similarity). Participates in AID/AICDA-mediated Ig class switching recombination (CSR)."},{"id":"ENSMUSP00000064865","abundance":27.6,"rank":2374,"name":"Hbb-bh1","annotation":"Hemoglobin subunit beta-H1; This is an embryonic beta-type chain."},{"id":"ENSMUSP00000037417","abundance":27.6,"rank":2375,"name":"Phpt1","annotation":"14 kDa phosphohistidine phosphatase; Exhibits phosphohistidine phosphatase activity."},{"id":"ENSMUSP00000039821","abundance":27.5,"rank":2376,"name":"Sprr2d","annotation":"Small proline-rich protein 2D; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)."},{"id":"ENSMUSP00000023391","abundance":27.5,"rank":2377,"name":"Mrpl40","annotation":"39S ribosomal protein L40, mitochondrial."},{"id":"ENSMUSP00000017148","abundance":27.5,"rank":2378,"name":"Svs5","annotation":"Seminal vesicle secretory protein 5."},{"id":"ENSMUSP00000043123","abundance":27.5,"rank":2379,"name":"Srrt","annotation":"Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. [...] "},{"id":"ENSMUSP00000027358","abundance":27.4,"rank":2380,"name":"Bcs1l","annotation":"Mitochondrial chaperone BCS1; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity)."},{"id":"ENSMUSP00000072598","abundance":27.4,"rank":2381,"name":"Ugt2b38","annotation":"UDP glucuronosyltransferase 2 family, polypeptide B38."},{"id":"ENSMUSP00000095263","abundance":27.4,"rank":2382,"name":"Ugt1a5","annotation":"UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000142720","abundance":27.4,"rank":2383,"name":"Tfr2","annotation":"Transferrin receptor protein 2; Mediates cellular uptake of transferrin-bound iron in a non- iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation; Belongs to the peptidase M28 family. M28B subfamily."},{"id":"ENSMUSP00000099324","abundance":27.3,"rank":2384,"name":"Kctd2","annotation":"BTB/POZ domain-containing protein KCTD2."},{"id":"ENSMUSP00000043662","abundance":27.3,"rank":2385,"name":"Sf3b6","annotation":"Splicing factor 3B subunit 6; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch si [...] "},{"id":"ENSMUSP00000107729","abundance":27.3,"rank":2386,"name":"Itga6","annotation":"Integrin alpha-6 heavy chain; Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (By similarity). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this  [...] "},{"id":"ENSMUSP00000157791","abundance":27.2,"rank":2387,"name":"Fech","annotation":"Ferrochelatase, mitochondrial; Catalyzes the ferrous insertion into protoporphyrin IX."},{"id":"ENSMUSP00000033617","abundance":27.2,"rank":2388,"name":"Btk","annotation":"Tyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker prote [...] "},{"id":"ENSMUSP00000079379","abundance":27.1,"rank":2389,"name":"Abce1","annotation":"ATP-binding cassette sub-family E member 1; Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'- linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway (By similarity); Belongs to the ABC transporter superfamily. ABCE family."},{"id":"ENSMUSP00000027602","abundance":27.1,"rank":2390,"name":"Dars","annotation":"Aspartate--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily."},{"id":"ENSMUSP00000115512","abundance":27.1,"rank":2391,"name":"Mrpl15","annotation":"39S ribosomal protein L15, mitochondrial."},{"id":"ENSMUSP00000023353","abundance":27.1,"rank":2392,"name":"Mcm4","annotation":"DNA replication licensing factor MCM4; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] "},{"id":"ENSMUSP00000049457","abundance":27,"rank":2393,"name":"Cacna2d1","annotation":"Voltage-dependent calcium channel subunit alpha-2/delta-1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation- contraction coupling (By similarity)."},{"id":"ENSMUSP00000044587","abundance":27,"rank":2394,"name":"Nat8f2","annotation":"N-acetyltransferase family 8 member 2; Probable acetyltransferase (Probable). Has no detectable histone acetyltransferase activity towards histone H3 or H4. Belongs to the camello family."},{"id":"ENSMUSP00000022749","abundance":27,"rank":2395,"name":"C9","annotation":"Complement component C9; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC; Belongs to the complement C6/C7/C8/C9 family."},{"id":"ENSMUSP00000033040","abundance":27,"rank":2396,"name":"Pak1","annotation":"Serine/threonine-protein kinase PAK 1; Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes. Can directly phosphorylate BAD and protects cells against apoptosis. Activated by interaction with CDC42 and RAC1. Functions as GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway. Phosphorylates and activates MAP2K1, and thereby media [...] "},{"id":"ENSMUSP00000086988","abundance":27,"rank":2397,"name":"Ddrgk1","annotation":"DDRGK domain-containing protein 1; Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B (By similarity). May also play a role in the cellular response to endoplasmic reticulum stress. Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasoma [...] "},{"id":"ENSMUSP00000159091","abundance":26.9,"rank":2398,"name":"Atpaf2","annotation":"ATP synthase mitochondrial F1 complex assembly factor 2; May play a role in the assembly of the F1 component of the mitochondrial ATP synthase (ATPase)."},{"id":"ENSMUSP00000105307","abundance":26.9,"rank":2399,"name":"Itch","annotation":"E3 ubiquitin-protein ligase Itchy; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It catalyzes 'Lys- 29'-, 'Lys-48'- and 'Lys-63'-linked ubiquitin conjugation (By similarity). Involved in the control of inflammatory signaling pathways (By similarity). Is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, TAX1BP1 and RNF11, that ensures the transient nature of inflammatory signaling pathways (By similari [...] "},{"id":"ENSMUSP00000028926","abundance":26.8,"rank":2400,"name":"Napb","annotation":"Beta-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus; Belongs to the SNAP family."},{"id":"ENSMUSP00000020057","abundance":26.8,"rank":2401,"name":"Lin7a","annotation":"Protein lin-7 homolog A; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may funct [...] "},{"id":"ENSMUSP00000112438","abundance":26.8,"rank":2402,"name":"Syt2","annotation":"Synaptotagmin-2; Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes (By similarity).  (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG); gangliosides are not required for (or only very slightly improve) binding to a membrane-anchored receptor fragment. The toxin binds via the vesicular domain (residues 47-55) ; Belongs to the synaptotagmin family."},{"id":"ENSMUSP00000056027","abundance":26.7,"rank":2403,"name":"Sigmar1","annotation":"Sigma non-opioid intracellular receptor 1; Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum.  [...] "},{"id":"ENSMUSP00000084259","abundance":26.7,"rank":2404,"name":"Jchain","annotation":"Immunoglobulin J chain; Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component."},{"id":"ENSMUSP00000121744","abundance":26.7,"rank":2405,"name":"Slc4a4","annotation":"Electrogenic sodium bicarbonate cotransporter 1; Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH; Belongs to the anion exchanger (TC 2.A.31) family."},{"id":"ENSMUSP00000035429","abundance":26.7,"rank":2406,"name":"Fxyd2","annotation":"Sodium/potassium-transporting ATPase subunit gamma; May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase."},{"id":"ENSMUSP00000015171","abundance":26.7,"rank":2407,"name":"Galns","annotation":"N-acetylgalactosamine-6-sulfatase; Belongs to the sulfatase family."},{"id":"ENSMUSP00000110897","abundance":26.7,"rank":2408,"name":"Ahcyl2","annotation":"Putative adenosylhomocysteinase 3; May regulate the electrogenic sodium/bicarbonate cotransporter SLC4A4 activity and Mg(2+)-sensitivity. On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate."},{"id":"ENSMUSP00000023071","abundance":26.6,"rank":2409,"name":"Samm50","annotation":"Sorting and assembly machinery component 50 homolog; Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex; Belongs to the SAM50/omp85 family."},{"id":"ENSMUSP00000059801","abundance":26.6,"rank":2410,"name":"Pfkm","annotation":"ATP-dependent 6-phosphofructokinase, muscle type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis."},{"id":"ENSMUSP00000021147","abundance":26.6,"rank":2411,"name":"Exoc7","annotation":"Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion; Belongs to the EXO70 family."},{"id":"ENSMUSP00000126887","abundance":26.6,"rank":2412,"name":"Gm10320","annotation":"Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum."},{"id":"ENSMUSP00000104936","abundance":26.6,"rank":2413,"name":"Cpt1b","annotation":"Carnitine O-palmitoyltransferase 1, muscle isoform."},{"id":"ENSMUSP00000125722","abundance":26.6,"rank":2414,"name":"Ppp3cb","annotation":"Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32; Belongs to the PPP phosphatase family. PP-2B subfamily."},{"id":"ENSMUSP00000112481","abundance":26.6,"rank":2415,"name":"Ctsf","annotation":"Cathepsin F; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis."},{"id":"ENSMUSP00000103362","abundance":26.6,"rank":2416,"name":"Kat7","annotation":"Histone acetyltransferase KAT7; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1. Specifically represses AR-mediated transcription; Belongs to the MYST (SAS/MOZ) family."},{"id":"ENSMUSP00000023072","abundance":26.5,"rank":2417,"name":"Parvb","annotation":"Beta-parvin; Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration (By similarity); Belongs to the parvin family."},{"id":"ENSMUSP00000122124","abundance":26.5,"rank":2418,"name":"Slc35d1","annotation":"UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter; Transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N- acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen. Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development. Belongs to the TPT transporter family. SLC35D subfamily."},{"id":"ENSMUSP00000029770","abundance":26.5,"rank":2419,"name":"Abcd3","annotation":"ATP-binding cassette sub-family D member 3; Probable transporter involved in the transport of branched- chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis. The nucleotide- binding fold acts as an ATP-binding subunit with ATPase activity. Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily."},{"id":"ENSMUSP00000044945","abundance":26.5,"rank":2420,"name":"Cryzl2","annotation":"Quinone oxidoreductase-like protein 2."},{"id":"ENSMUSP00000099744","abundance":26.4,"rank":2421,"name":"Tom1l2","annotation":"TOM1-like protein 2; Probable role in protein transport. May regulate growth factor-induced mitogenic signaling (By similarity); Belongs to the TOM1 family."},{"id":"ENSMUSP00000059498","abundance":26.3,"rank":2422,"name":"Rhoj","annotation":"Rho-related GTP-binding protein RhoJ; Plasma membrane-associated small GTPase specifically involved in angiogenesis (By similarity). Required for endothelial cell migration during vascular development via its interaction with GLUL (By similarity). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration. Belongs to the small GTPase superfamily. Rho family."},{"id":"ENSMUSP00000006293","abundance":26.3,"rank":2423,"name":"Crkl","annotation":"Crk-like protein; May mediate the transduction of intracellular signals."},{"id":"ENSMUSP00000028916","abundance":26.3,"rank":2424,"name":"Sec23b","annotation":"Protein transport protein Sec23B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex."},{"id":"ENSMUSP00000022256","abundance":26.3,"rank":2425,"name":"Psmd6","annotation":"26S proteasome non-ATPase regulatory subunit 6; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S10 family."},{"id":"ENSMUSP00000066092","abundance":26.3,"rank":2426,"name":"Ech1","annotation":"Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; Isomerization of 3-trans,5-cis-dienoyl-CoA to 2-trans,4- trans-dienoyl-CoA; Belongs to the enoyl-CoA hydratase/isomerase family."},{"id":"ENSMUSP00000091011","abundance":26.3,"rank":2427,"name":"Grb10","annotation":"Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] "},{"id":"ENSMUSP00000055619","abundance":26.3,"rank":2428,"name":"Mrps16","annotation":"28S ribosomal protein S16, mitochondrial; Belongs to the bacterial ribosomal protein bS16 family."},{"id":"ENSMUSP00000118348","abundance":26.3,"rank":2429,"name":"Bola3","annotation":"BolA-like protein 3; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1."},{"id":"ENSMUSP00000025385","abundance":26.2,"rank":2430,"name":"Hsd17b4","annotation":"Peroxisomal multifunctional enzyme type 2; Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids (By similarity)."},{"id":"ENSMUSP00000028135","abundance":26.2,"rank":2431,"name":"Fam129b","annotation":"Protein Niban 2; May play a role in apoptosis suppression."},{"id":"ENSMUSP00000117030","abundance":26.2,"rank":2432,"name":"Pfkp","annotation":"ATP-dependent 6-phosphofructokinase, platelet type; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis."},{"id":"ENSMUSP00000048439","abundance":26.2,"rank":2433,"name":"Krt25","annotation":"Keratin, type I cytoskeletal 25; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs). Plays a role in the cytoskeleton organization (By similarity)."},{"id":"ENSMUSP00000034285","abundance":26.2,"rank":2434,"name":"Cotl1","annotation":"Coactosin-like protein; Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis (By similarity)."},{"id":"ENSMUSP00000015501","abundance":26.2,"rank":2435,"name":"Clpx","annotation":"ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial; ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP. Targets specific substrates for degradation by the Clp complex. Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure. ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5- aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in h [...] "},{"id":"ENSMUSP00000054583","abundance":26.2,"rank":2436,"name":"Fbln1","annotation":"Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes."},{"id":"ENSMUSP00000036087","abundance":26.2,"rank":2437,"name":"Gnaz","annotation":"Guanine nucleotide-binding protein G(z) subunit alpha; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems."},{"id":"ENSMUSP00000067830","abundance":26.1,"rank":2438,"name":"Dglucy","annotation":"D-glutamate cyclase, mitochondrial; D-glutamate cyclase that converts D-glutamate to 5-oxo-D- proline."},{"id":"ENSMUSP00000006367","abundance":26.1,"rank":2439,"name":"Htra1","annotation":"Serine protease HTRA1; Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF- binding proteins. Inhibits sign [...] "},{"id":"ENSMUSP00000022793","abundance":26.1,"rank":2440,"name":"Acin1","annotation":"Apoptotic chromatin condensation inducer in the nucleus; Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate  [...] "},{"id":"ENSMUSP00000021948","abundance":26.1,"rank":2441,"name":"F12","annotation":"Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity)."},{"id":"ENSMUSP00000069965","abundance":26.1,"rank":2442,"name":"Opa3","annotation":"Optic atrophy 3 protein homolog; May play some role in mitochondrial processes; Belongs to the OPA3 family."},{"id":"ENSMUSP00000034115","abundance":26.1,"rank":2443,"name":"Pou4f2","annotation":"POU domain, class 4, transcription factor 2; Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor by modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; coo [...] "},{"id":"ENSMUSP00000148404","abundance":26.1,"rank":2444,"name":"Csnk2a2","annotation":"Casein kinase II subunit alpha; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoin [...] "},{"id":"ENSMUSP00000117466","abundance":26.1,"rank":2445,"name":"Pakap-3","annotation":"Paralemmin A kinase anchor protein."},{"id":"ENSMUSP00000117160","abundance":26.1,"rank":2446,"name":"Sf3a2","annotation":"Splicing factor 3A subunit 2; Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron; Belongs to the SF3A2 family."},{"id":"ENSMUSP00000023453","abundance":26.1,"rank":2447,"name":"Sdf2l1","annotation":"Stromal cell-derived factor 2-like protein 1."},{"id":"ENSMUSP00000096179","abundance":26.1,"rank":2448,"name":"Mttp","annotation":"Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins. Loads phospholipid into the C1D1 antigen-binding groove. Isoform 2 is critical for the development of natural killer T (NKT) cells. May have a role in the biogenesis of lipid droplets."},{"id":"ENSMUSP00000109409","abundance":26,"rank":2449,"name":"Eda","annotation":"Ectodysplasin-A, membrane form; Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R. Isoform TAA binds only to the receptor EDAR, while isoform TA-A2 binds exclusively to the receptor EDA2R (By similarity). May also play a role in cell adhesion. Isoform TA-A2 binds exclusively to the receptor EDA2R. Belongs to the tumor necrosis factor family."},{"id":"ENSMUSP00000030644","abundance":26,"rank":2450,"name":"Zfp593","annotation":"Zinc finger protein 593; Negatively modulates the DNA binding activity of Oct-2 and therefore its transcriptional regulatory activity. Could act either by binding to DNA octamer or by interacting with Oct-2. May also be a modulator of other octamer-binding proteins (By similarity)."},{"id":"ENSMUSP00000073459","abundance":26,"rank":2451,"name":"Akr7a5","annotation":"Aflatoxin B1 aldehyde reductase member 2; Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity)."},{"id":"ENSMUSP00000056643","abundance":26,"rank":2452,"name":"Pgrmc2","annotation":"Membrane-associated progesterone receptor component 2; Receptor for steroids."},{"id":"ENSMUSP00000035157","abundance":26,"rank":2453,"name":"Srprb","annotation":"Signal recognition particle receptor subunit beta; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR."},{"id":"ENSMUSP00000017743","abundance":25.9,"rank":2454,"name":"Krt20","annotation":"Keratin, type I cytoskeletal 20; Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine. Belongs to the intermediate filament family."},{"id":"ENSMUSP00000098677","abundance":25.9,"rank":2455,"name":"Rybp","annotation":"RING1 and YY1-binding protein; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one co [...] "},{"id":"ENSMUSP00000052872","abundance":25.9,"rank":2456,"name":"Fasn","annotation":"3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein."},{"id":"ENSMUSP00000108940","abundance":25.8,"rank":2457,"name":"Sult1d1","annotation":"Sulfotransferase 1 family member D1; Sulfotransferase with broad substrate specificity that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, such as dopamine, prostaglandins, leukotriene E4, drugs and xenobiotic compounds. Has sulfotransferase activity towards p-nitrophenol, 2-naphthylamine and minoxidil (in vitro). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites."},{"id":"ENSMUSP00000005705","abundance":25.8,"rank":2458,"name":"Trim28","annotation":"Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] "},{"id":"ENSMUSP00000044827","abundance":25.8,"rank":2459,"name":"Mybbp1a","annotation":"Myb-binding protein 1A; May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. Has a role in rRNA biogenesis together with PWP1 (By similarity). Belongs to the MYBBP1A family."},{"id":"ENSMUSP00000044639","abundance":25.8,"rank":2460,"name":"Rhot2","annotation":"Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity)."},{"id":"ENSMUSP00000140896","abundance":25.7,"rank":2461,"name":"Rnf2","annotation":"E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, i [...] "},{"id":"ENSMUSP00000048470","abundance":25.7,"rank":2462,"name":"Rbm25","annotation":"RNA-binding protein 25; RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7 [...] "},{"id":"ENSMUSP00000031099","abundance":25.7,"rank":2463,"name":"Grpel1","annotation":"GrpE protein homolog 1, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity)."},{"id":"ENSMUSP00000021040","abundance":25.7,"rank":2464,"name":"Cct6b","annotation":"T-complex protein 1 subunit zeta-2; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis; Belongs to the TCP-1 chaperonin family."},{"id":"ENSMUSP00000023088","abundance":25.6,"rank":2465,"name":"Naga","annotation":"Alpha-N-acetylgalactosaminidase; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids (By similarity); Belongs to the glycosyl hydrolase 27 family."},{"id":"ENSMUSP00000111204","abundance":25.6,"rank":2466,"name":"Asns","annotation":"Asparagine synthetase [glutamine-hydrolyzing]."},{"id":"ENSMUSP00000045291","abundance":25.6,"rank":2467,"name":"Acsl3","annotation":"Long-chain-fatty-acid--CoA ligase 3; Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta- oxidation (By similarity). ACSL3 is required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (By similarity). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity [...] "},{"id":"ENSMUSP00000071662","abundance":25.6,"rank":2468,"name":"Col12a1","annotation":"Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family."},{"id":"ENSMUSP00000113527","abundance":25.6,"rank":2469,"name":"Cdh13","annotation":"Cadherin-13; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth."},{"id":"ENSMUSP00000042389","abundance":25.6,"rank":2470,"name":"Svs2","annotation":"Seminal vesicle secretory protein 2."},{"id":"ENSMUSP00000049729","abundance":25.6,"rank":2471,"name":"Masp2","annotation":"Mannan-binding lectin serine protease 2 A chain; Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase (By similarity). Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000015812","abundance":25.6,"rank":2472,"name":"Pdzd11","annotation":"PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33."},{"id":"ENSMUSP00000080992","abundance":25.5,"rank":2473,"name":"mt-Nd2","annotation":"NADH-ubiquinone oxidoreductase chain 2; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000107390","abundance":25.5,"rank":2474,"name":"Nckap1","annotation":"Nck-associated protein 1; Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes ; Belongs to the HEM-1/HEM-2 family."},{"id":"ENSMUSP00000043167","abundance":25.5,"rank":2475,"name":"Gns","annotation":"N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family."},{"id":"ENSMUSP00000073975","abundance":25.5,"rank":2476,"name":"Pdcd4","annotation":"Programmed cell death protein 4; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA."},{"id":"ENSMUSP00000030882","abundance":25.5,"rank":2477,"name":"Pmpcb","annotation":"Mitochondrial-processing peptidase subunit beta; Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (By similarity). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (By similarity). Belongs to the peptidase M16 family."},{"id":"ENSMUSP00000094750","abundance":25.5,"rank":2478,"name":"Sept5","annotation":"Septin-5; Filament-forming cytoskeletal GTPase (By similarity). Involved in cytokinesis (Potential). May play a role in platelet secretion; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family."},{"id":"ENSMUSP00000049394","abundance":25.5,"rank":2479,"name":"Cbr1","annotation":"Carbonyl reductase [NADPH] 1; NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2- alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S- nitrosoglutathione (By similarity) [...] "},{"id":"ENSMUSP00000029092","abundance":25.5,"rank":2480,"name":"Arfgap1","annotation":"ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, a [...] "},{"id":"ENSMUSP00000086422","abundance":25.4,"rank":2481,"name":"Tm9sf4","annotation":"Transmembrane 9 superfamily member 4; Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family."},{"id":"ENSMUSP00000085993","abundance":25.4,"rank":2482,"name":"Srrm2","annotation":"Serine/arginine repetitive matrix protein 2; Required for pre-mRNA splicing as component of the spliceosome; Belongs to the CWC21 family."},{"id":"ENSMUSP00000053849","abundance":25.4,"rank":2483,"name":"Sprr2h","annotation":"Small proline-rich protein 2H; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity); Belongs to the cornifin (SPRR) family."},{"id":"ENSMUSP00000091608","abundance":25.4,"rank":2484,"name":"Tmem256","annotation":"Transmembrane protein 256."},{"id":"ENSMUSP00000099919","abundance":25.4,"rank":2485,"name":"Crat","annotation":"Carnitine O-acetyltransferase; Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta- oxidation. May be specific for short chain fatty acids. Belongs to the carnitine/choline acetyltransferase family."},{"id":"ENSMUSP00000113365","abundance":25.3,"rank":2486,"name":"Pex11b","annotation":"Peroxisomal membrane protein 11B; Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family."},{"id":"ENSMUSP00000130898","abundance":25.3,"rank":2487,"name":"Nt5c2","annotation":"Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). Belongs to the 5'(3')-deoxyribonucleotidase family."},{"id":"ENSMUSP00000006431","abundance":25.3,"rank":2488,"name":"Atp6v1b1","annotation":"Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family."},{"id":"ENSMUSP00000053175","abundance":25.3,"rank":2489,"name":"Sdf4","annotation":"45 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment."},{"id":"ENSMUSP00000000608","abundance":25.3,"rank":2490,"name":"Gm2a","annotation":"Ganglioside GM2 activator; Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity."},{"id":"ENSMUSP00000029925","abundance":25.3,"rank":2491,"name":"Ndufaf4","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; May be involved in cell proliferation and survival of hormone-dependent tumor cells. Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity); Belongs to the NDUFAF4 family."},{"id":"ENSMUSP00000021133","abundance":25.3,"rank":2492,"name":"Srp68","annotation":"Signal recognition particle subunit SRP68; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity)."},{"id":"ENSMUSP00000005798","abundance":25.2,"rank":2493,"name":"Snx6","annotation":"Sorting nexin-6, N-terminally processed; Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome- to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile call [...] "},{"id":"ENSMUSP00000103983","abundance":25.2,"rank":2494,"name":"Ythdf3","annotation":"YTH domain-containing family protein 3; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs and promotes RNA translation efficiency (By similarity). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (By similarity). Shares m6A- containing mRNAs targets with YTHDF1 and YTHDF2, and regulates different processes depending on the context (By similarity). Facilitates the translation of targeted mRNAs in cooperation with YTHDF1 by binding to m6A-containing mRN [...] "},{"id":"ENSMUSP00000035220","abundance":25.2,"rank":2495,"name":"Prkar2a","annotation":"cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase."},{"id":"ENSMUSP00000100534","abundance":25.2,"rank":2496,"name":"Mcts2","annotation":"Malignant T-cell-amplified sequence 2."},{"id":"ENSMUSP00000059192","abundance":25.2,"rank":2497,"name":"Mcm3","annotation":"DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] "},{"id":"ENSMUSP00000099853","abundance":25.2,"rank":2498,"name":"Cd47","annotation":"Leukocyte surface antigen CD47; Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integ [...] "},{"id":"ENSMUSP00000030041","abundance":25.2,"rank":2499,"name":"Ambp","annotation":"Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity); In the N-terminal section; belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000045955","abundance":25.2,"rank":2500,"name":"Sec24c","annotation":"Sec24-related gene family, member C (S. cerevisiae)."},{"id":"ENSMUSP00000096445","abundance":25.2,"rank":2501,"name":"Epn1","annotation":"Epsin-1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis."},{"id":"ENSMUSP00000016338","abundance":25.2,"rank":2502,"name":"Hsd11b1","annotation":"Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone."},{"id":"ENSMUSP00000100565","abundance":25.1,"rank":2503,"name":"Gm12184","annotation":"Predicted gene 12184."},{"id":"ENSMUSP00000031341","abundance":25.1,"rank":2504,"name":"Cdk2ap1","annotation":"Cyclin-dependent kinase 2-associated protein 1; specific inhibitor of the cell-cycle kinase CDK2."},{"id":"ENSMUSP00000051621","abundance":25.1,"rank":2505,"name":"Mmgt1","annotation":"Membrane magnesium transporter 1; Mediates Mg(2+) transport."},{"id":"ENSMUSP00000053809","abundance":25.1,"rank":2506,"name":"Nqo2","annotation":"Ribosyldihydronicotinamide dehydrogenase [quinone]; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis."},{"id":"ENSMUSP00000138326","abundance":25.1,"rank":2507,"name":"Ank3","annotation":"Ankyrin-3; Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for costamere localization of DMD and betaDAG1. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption."},{"id":"ENSMUSP00000064706","abundance":25,"rank":2508,"name":"Cadps","annotation":"Calcium-dependent secretion activator 1; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2- binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in [...] "},{"id":"ENSMUSP00000103141","abundance":25,"rank":2509,"name":"Mup6","annotation":"Novel member of the major urinary protein (Mup) gene family; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000059167","abundance":25,"rank":2510,"name":"Ctbs","annotation":"Di-N-acetylchitobiase; Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-D-glucosamine (1-4)N- acetylglucosamine chitobiose core from the reducing end of the bond, it requires prior cleavage by glycosylasparaginase (By similarity)."},{"id":"ENSMUSP00000034915","abundance":25,"rank":2511,"name":"Ctsh","annotation":"Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000046388","abundance":25,"rank":2512,"name":"Ncoa5","annotation":"Nuclear receptor coactivator 5; Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) (By similarity)."},{"id":"ENSMUSP00000104298","abundance":25,"rank":2513,"name":"Trp53","annotation":"Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] "},{"id":"ENSMUSP00000076735","abundance":24.9,"rank":2514,"name":"Rdh19","annotation":"Retinol dehydrogenase 19; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000078088","abundance":24.9,"rank":2515,"name":"Aqp4","annotation":"Aquaporin-4; Forms a water-specific channel. Plays an important role in brain water homeostasis and in glymphatic solute transport. Required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from [...] "},{"id":"ENSMUSP00000000642","abundance":24.9,"rank":2516,"name":"Hk2","annotation":"Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis."},{"id":"ENSMUSP00000021052","abundance":24.9,"rank":2517,"name":"Smarcd2","annotation":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation."},{"id":"ENSMUSP00000019231","abundance":24.8,"rank":2518,"name":"Atp6ap1","annotation":"V-type proton ATPase subunit S1; Accessory subunit of the proton-transporting vacuolar (V)- ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering th [...] "},{"id":"ENSMUSP00000122061","abundance":24.8,"rank":2519,"name":"Ly6h","annotation":"Lymphocyte antigen 6H; Believed to act as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. In vitro inhibits alpha-3:beta-4- containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By similarity)."},{"id":"ENSMUSP00000119330","abundance":24.8,"rank":2520,"name":"Comtd1","annotation":"Catechol O-methyltransferase domain-containing protein 1; Putative O-methyltransferase."},{"id":"ENSMUSP00000021375","abundance":24.8,"rank":2521,"name":"Sec23a","annotation":"Protein transport protein Sec23A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (By similarity). Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane ; Belongs to the SEC23/SEC24 family. SEC23 subfamily."},{"id":"ENSMUSP00000033695","abundance":24.7,"rank":2522,"name":"Abcb7","annotation":"ATP-binding cassette sub-family B member 7, mitochondrial; Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins."},{"id":"ENSMUSP00000092230","abundance":24.7,"rank":2523,"name":"Vps4b","annotation":"Vacuolar protein sorting-associated protein 4B; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] "},{"id":"ENSMUSP00000090673","abundance":24.7,"rank":2524,"name":"Sco1","annotation":"Protein SCO1 homolog, mitochondrial; Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT- CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (By similarity). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 ; Belongs to the SCO1/2 family."},{"id":"ENSMUSP00000104228","abundance":24.7,"rank":2525,"name":"Tnnt1","annotation":"Troponin T, slow skeletal muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity."},{"id":"ENSMUSP00000071654","abundance":24.7,"rank":2526,"name":"Gsk3a","annotation":"Glycogen synthase kinase-3 alpha; Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. M [...] "},{"id":"ENSMUSP00000030202","abundance":24.7,"rank":2527,"name":"Glipr2","annotation":"Golgi-associated plant pathogenesis-related protein 1; Belongs to the CRISP family."},{"id":"ENSMUSP00000022925","abundance":24.6,"rank":2528,"name":"Eif3h","annotation":"Eukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] "},{"id":"ENSMUSP00000107294","abundance":24.6,"rank":2529,"name":"Tmx2","annotation":"Thioredoxin-related transmembrane protein 2."},{"id":"ENSMUSP00000140993","abundance":24.6,"rank":2530,"name":"Larp4b","annotation":"La-related protein 4B; Stimulates mRNA translation."},{"id":"ENSMUSP00000043033","abundance":24.6,"rank":2531,"name":"Cdc123","annotation":"Cell division cycle protein 123 homolog; Required for S phase entry of the cell cycle; Belongs to the CDC123 family."},{"id":"ENSMUSP00000038502","abundance":24.6,"rank":2532,"name":"Cplx1","annotation":"Complexin-1; Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior ; Belongs to the complexin/synaphin family."},{"id":"ENSMUSP00000120387","abundance":24.5,"rank":2533,"name":"Arfip2","annotation":"Arfaptin-2; Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Participates also in autophagy by regulating the starvation-depdendent trafficking of ATG9A vesicles which deliver the PI4-kinase to the autophagosome initiation site. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG."},{"id":"ENSMUSP00000076856","abundance":24.5,"rank":2534,"name":"Col4a3bp","annotation":"Ceramide transfer protein; Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner."},{"id":"ENSMUSP00000112942","abundance":24.5,"rank":2535,"name":"Pld3","annotation":"5'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity)."},{"id":"ENSMUSP00000105663","abundance":24.5,"rank":2536,"name":"Ptk2","annotation":"Focal adhesion kinase 1; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; required f [...] "},{"id":"ENSMUSP00000046641","abundance":24.5,"rank":2537,"name":"Zfp503","annotation":"Zinc finger protein 503; May function as a transcriptional repressor."},{"id":"ENSMUSP00000069554","abundance":24.5,"rank":2538,"name":"Yap1","annotation":"Transcriptional coactivator YAP1; Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncopro [...] "},{"id":"ENSMUSP00000021514","abundance":24.4,"rank":2539,"name":"Ppm1a","annotation":"Protein phosphatase 1A; Enzyme with a broad specificity. Negatively regulates TGF- beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB."},{"id":"ENSMUSP00000099576","abundance":24.4,"rank":2540,"name":"Ece1","annotation":"Endothelin-converting enzyme 1; Converts big endothelin-1 to endothelin-1."},{"id":"ENSMUSP00000128030","abundance":24.4,"rank":2541,"name":"Cyp2a22","annotation":"Cytochrome P450, family 2, subfamily a, polypeptide 22; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000092849","abundance":24.4,"rank":2542,"name":"Safb","annotation":"Scaffold attachment factor B1; Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter."},{"id":"ENSMUSP00000136717","abundance":24.4,"rank":2543,"name":"4931406C07Rik","annotation":"Ester hydrolase C11orf54 homolog; Exhibits ester hydrolase activity on the substrate p- nitrophenyl acetate."},{"id":"ENSMUSP00000021790","abundance":24.3,"rank":2544,"name":"Tmem14c","annotation":"Transmembrane protein 14C; Required for normal heme biosynthesis; Belongs to the TMEM14 family."},{"id":"ENSMUSP00000156088","abundance":24.3,"rank":2545,"name":"Gm49601","annotation":"Predicted gene, 49601; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family."},{"id":"ENSMUSP00000041732","abundance":24.3,"rank":2546,"name":"Ppp1r9b","annotation":"Neurabin-2; Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross- linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Pl [...] "},{"id":"ENSMUSP00000037258","abundance":24.3,"rank":2547,"name":"Ugt1a2","annotation":"UDP-glucuronosyltransferase 1-2; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds."},{"id":"ENSMUSP00000020298","abundance":24.3,"rank":2548,"name":"Pcbd1","annotation":"Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family."},{"id":"ENSMUSP00000130930","abundance":24.2,"rank":2549,"name":"Tgif1","annotation":"Homeobox protein TGIF1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities (By similarity); Belongs to the TALE/TGIF homeobox family."},{"id":"ENSMUSP00000079124","abundance":24.2,"rank":2550,"name":"Birc5","annotation":"Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized micro [...] "},{"id":"ENSMUSP00000032508","abundance":24.2,"rank":2551,"name":"Fkbp4","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May  [...] "},{"id":"ENSMUSP00000050962","abundance":24.2,"rank":2552,"name":"Akap4","annotation":"A-kinase anchor protein 4; Major structural component of sperm fibrous sheath. Plays a role in sperm motility."},{"id":"ENSMUSP00000081782","abundance":24.2,"rank":2553,"name":"Ipo7","annotation":"Importin-7; Functions in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm  [...] "},{"id":"ENSMUSP00000033444","abundance":24.2,"rank":2554,"name":"Stk26","annotation":"Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation."},{"id":"ENSMUSP00000109571","abundance":24.2,"rank":2555,"name":"Mrpl53","annotation":"39S ribosomal protein L53, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL53 family."},{"id":"ENSMUSP00000132100","abundance":24.2,"rank":2556,"name":"Tgfb1i1","annotation":"Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. [...] "},{"id":"ENSMUSP00000139564","abundance":24.2,"rank":2557,"name":"Mag","annotation":"Myelin-associated glycoprotein; Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid- containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangl [...] "},{"id":"ENSMUSP00000006128","abundance":24.2,"rank":2558,"name":"Rcn1","annotation":"Reticulocalbin-1; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family."},{"id":"ENSMUSP00000060892","abundance":24.2,"rank":2559,"name":"Emc6","annotation":"ER membrane protein complex subunit 6; Belongs to the EMC6 family."},{"id":"ENSMUSP00000001927","abundance":24.2,"rank":2560,"name":"Ltbp1","annotation":"Latent-transforming growth factor beta-binding protein 1; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta."},{"id":"ENSMUSP00000128871","abundance":24.1,"rank":2561,"name":"Csnk1a1","annotation":"Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity)."},{"id":"ENSMUSP00000126135","abundance":24.1,"rank":2562,"name":"Mcm5","annotation":"DNA replication licensing factor MCM5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] "},{"id":"ENSMUSP00000119827","abundance":24.1,"rank":2563,"name":"Apod","annotation":"Apolipoprotein D; APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000041967","abundance":24.1,"rank":2564,"name":"Agps","annotation":"Alkyldihydroxyacetonephosphate synthase, peroxisomal; Catalyzes the exchange of the acyl chain in acyl- dihydroxyacetonephosphate (acyl-DHAP) for a long chain fatty alcohol, yielding the first ether linked intermediate, i.e. alkyl- dihydroxyacetonephosphate (alkyl-DHAP), in the pathway of ether lipid biosynthesis; Belongs to the FAD-binding oxidoreductase/transferase type 4 family."},{"id":"ENSMUSP00000025656","abundance":24.1,"rank":2565,"name":"Aldh1a7","annotation":"Aldehyde dehydrogenase, cytosolic 1; Can oxidize benzaldehyde, propionaldehyde and acetaldehyde (By similarity). No detectable activity with retinal."},{"id":"ENSMUSP00000072334","abundance":24,"rank":2566,"name":"Elmo1","annotation":"Engulfment and cell motility protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity)."},{"id":"ENSMUSP00000125492","abundance":24,"rank":2567,"name":"Hgd","annotation":"Homogentisate 1,2-dioxygenase."},{"id":"ENSMUSP00000011058","abundance":24,"rank":2568,"name":"Pdhx","annotation":"Pyruvate dehydrogenase protein X component, mitochondrial; Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex (By similarity)."},{"id":"ENSMUSP00000022057","abundance":23.9,"rank":2569,"name":"Tppp","annotation":"Tubulin polymerization-promoting protein; Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath. Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath. Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes. Shows magnesium-dependent GTPase activity; the role of the GTPa [...] "},{"id":"ENSMUSP00000032561","abundance":23.9,"rank":2570,"name":"Vasp","annotation":"Vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end  [...] "},{"id":"ENSMUSP00000025254","abundance":23.9,"rank":2571,"name":"Lims2","annotation":"LIM and senescent cell antigen-like-containing domain protein 2; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors."},{"id":"ENSMUSP00000027802","abundance":23.9,"rank":2572,"name":"Pycr2","annotation":"Pyrroline-5-carboxylate reductase 2; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (By similarity). Involved in cellular response to oxidative stress (By similarity); Belongs to the pyrroline-5-carboxylate reductase family."},{"id":"ENSMUSP00000026624","abundance":23.9,"rank":2573,"name":"Tm9sf2","annotation":"Transmembrane 9 superfamily member 2; In the intracellular compartments, may function as a channel or small molecule transporter; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family."},{"id":"ENSMUSP00000124966","abundance":23.9,"rank":2574,"name":"Cpsf4","annotation":"Cleavage and polyadenylation specificity factor subunit 4; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U) (By similarity); Belongs to the CPSF4/YTH1 family."},{"id":"ENSMUSP00000028704","abundance":23.9,"rank":2575,"name":"Hao1","annotation":"Hydroxyacid oxidase 1; Has 2-hydroxyacid oxidase activity. Most active on the 2- carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate (By similarity); Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family."},{"id":"ENSMUSP00000102929","abundance":23.8,"rank":2576,"name":"Coasy","annotation":"Phosphopantetheine adenylyltransferase; Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation; In the central section; belongs to the eukaryotic CoaD family."},{"id":"ENSMUSP00000053033","abundance":23.8,"rank":2577,"name":"Mrps7","annotation":"28S ribosomal protein S7, mitochondrial; Belongs to the universal ribosomal protein uS7 family."},{"id":"ENSMUSP00000035222","abundance":23.8,"rank":2578,"name":"Slc25a20","annotation":"Mitochondrial carnitine/acylcarnitine carrier protein; Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway."},{"id":"ENSMUSP00000081010","abundance":23.7,"rank":2579,"name":"Gpx1","annotation":"Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown."},{"id":"ENSMUSP00000151661","abundance":23.7,"rank":2580,"name":"Hsd17b6","annotation":"17-beta-hydroxysteroid dehydrogenase type 6; NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17- beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro)."},{"id":"ENSMUSP00000065810","abundance":23.7,"rank":2581,"name":"Rtn3","annotation":"Reticulon-3; May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (By similarity). Induces the formation of endoplasmic reticulum tubules."},{"id":"ENSMUSP00000131504","abundance":23.7,"rank":2582,"name":"Pacsin2","annotation":"Protein kinase C and casein kinase substrate in neurons protein 2; Regulates the morphogenesis and endocytosis of caveolae. Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus."},{"id":"ENSMUSP00000045580","abundance":23.6,"rank":2583,"name":"Thoc5","annotation":"THO complex subunit 5 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. THOC5 in conjunction with AL [...] "},{"id":"ENSMUSP00000045036","abundance":23.6,"rank":2584,"name":"Myof","annotation":"Myoferlin; Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR."},{"id":"ENSMUSP00000109382","abundance":23.6,"rank":2585,"name":"Tprkb","annotation":"EKC/KEOPS complex subunit Tprkb; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification. Belongs to the CGI121/TPRKB family."},{"id":"ENSMUSP00000023450","abundance":23.6,"rank":2586,"name":"Serpind1","annotation":"Heparin cofactor 2; Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan- independent manner; Belongs to the serpin family."},{"id":"ENSMUSP00000128810","abundance":23.6,"rank":2587,"name":"Gm21992","annotation":"Predicted gene 21992."},{"id":"ENSMUSP00000025014","abundance":23.5,"rank":2588,"name":"Mrpl28","annotation":"39S ribosomal protein L28, mitochondrial; Belongs to the bacterial ribosomal protein bL28 family."},{"id":"ENSMUSP00000034346","abundance":23.5,"rank":2589,"name":"Ces2a","annotation":"Pyrethroid hydrolase Ces2a; Carboxylesterases that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes permethrin faster than cypermethrin."},{"id":"ENSMUSP00000151971","abundance":23.5,"rank":2590,"name":"Gm5039","annotation":"Predicted gene 5039; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000028755","abundance":23.5,"rank":2591,"name":"Ehd4","annotation":"EH domain-containing protein 4; ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport."},{"id":"ENSMUSP00000106970","abundance":23.5,"rank":2592,"name":"Ckap5","annotation":"Cytoskeleton-associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stab [...] "},{"id":"ENSMUSP00000005583","abundance":23.5,"rank":2593,"name":"Pafah1b3","annotation":"Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain; Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily."},{"id":"ENSMUSP00000103937","abundance":23.5,"rank":2594,"name":"Pdp1","annotation":"[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial; Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex."},{"id":"ENSMUSP00000003207","abundance":23.4,"rank":2595,"name":"Lipe","annotation":"Hormone-sensitive lipase; In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production; Belongs to the 'GDXG' lipolytic enzyme family."},{"id":"ENSMUSP00000136957","abundance":23.4,"rank":2596,"name":"Purb","annotation":"Transcriptional activator protein Pur-beta; Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). Plays a role in the control of vascular smooth muscle (VS [...] "},{"id":"ENSMUSP00000058131","abundance":23.4,"rank":2597,"name":"Sprr2b","annotation":"Small proline-rich protein 2B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)."},{"id":"ENSMUSP00000062284","abundance":23.4,"rank":2598,"name":"Grin2b","annotation":"Glutamate receptor ionotropic, NMDA 2B; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. [...] "},{"id":"ENSMUSP00000120106","abundance":23.4,"rank":2599,"name":"Pfdn2","annotation":"Prefoldin subunit 2; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins."},{"id":"ENSMUSP00000031707","abundance":23.4,"rank":2600,"name":"Aass","annotation":"Alpha-aminoadipic semialdehyde synthase, mitochondrial; Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine- oxoglutarate reductase and saccharopine dehydrogenase activity, respectively."},{"id":"ENSMUSP00000020262","abundance":23.4,"rank":2601,"name":"Pbld2","annotation":"Phenazine biosynthesis-like domain-containing protein 2; Belongs to the PhzF family."},{"id":"ENSMUSP00000047497","abundance":23.4,"rank":2602,"name":"Timm8a2","annotation":"Putative mitochondrial import inner membrane translocase subunit Tim8 A-B; Putative mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small  [...] "},{"id":"ENSMUSP00000078685","abundance":23.4,"rank":2603,"name":"Zfp422","annotation":"Zinc finger protein 22; Binds DNA through the consensus sequence 5'-CAATG-3'. May be involved in transcriptional regulation and may play a role in tooth formation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000032779","abundance":23.3,"rank":2604,"name":"Ctsc","annotation":"Dipeptidyl peptidase 1 exclusion domain chain; Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000083754","abundance":23.3,"rank":2605,"name":"Git2","annotation":"ARF GTPase-activating protein GIT2; GTPase-activating protein for the ADP ribosylation factor family."},{"id":"ENSMUSP00000026292","abundance":23.3,"rank":2606,"name":"Huwe1","annotation":"E3 ubiquitin-protein ligase HUWE1; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene (By similarity). Regulates neural differe [...] "},{"id":"ENSMUSP00000081001","abundance":23.3,"rank":2607,"name":"mt-Nd5","annotation":"NADH-ubiquinone oxidoreductase chain 5; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000126897","abundance":23.3,"rank":2608,"name":"Mov10","annotation":"Putative helicase MOV-10; Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity). In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2 (By similarity). Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity).  [...] "},{"id":"ENSMUSP00000099404","abundance":23.3,"rank":2609,"name":"Plcg1","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration."},{"id":"ENSMUSP00000116574","abundance":23.2,"rank":2610,"name":"Rdh16f1","annotation":"RDH16 family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000001480","abundance":23.2,"rank":2611,"name":"Npepps","annotation":"Puromycin-sensitive aminopeptidase; Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins."},{"id":"ENSMUSP00000124738","abundance":23.2,"rank":2612,"name":"Pou2f1","annotation":"POU domain, class 2, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity); Belongs to the POU transcription factor family. Class-2 subfamily."},{"id":"ENSMUSP00000091768","abundance":23.2,"rank":2613,"name":"Mesd","annotation":"LRP chaperone MESD; Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell- surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells. Belongs to the MESD family."},{"id":"ENSMUSP00000025713","abundance":23.2,"rank":2614,"name":"Tm7sf2","annotation":"Delta(14)-sterol reductase TM7SF2; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis; Belongs to the ERG4/ERG24 family."},{"id":"ENSMUSP00000000505","abundance":23.1,"rank":2615,"name":"Mcm7","annotation":"DNA replication licensing factor MCM7; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] "},{"id":"ENSMUSP00000040550","abundance":23.1,"rank":2616,"name":"Maob","annotation":"Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity)."},{"id":"ENSMUSP00000022962","abundance":23.1,"rank":2617,"name":"Emc2","annotation":"ER membrane protein complex subunit 2; Belongs to the EMC2 family."},{"id":"ENSMUSP00000072386","abundance":23.1,"rank":2618,"name":"Srp19","annotation":"Signal recognition particle 19 kDa protein; Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP."},{"id":"ENSMUSP00000037858","abundance":23.1,"rank":2619,"name":"Fermt3","annotation":"Fermitin family homolog 3; Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Belongs to the kindlin family."},{"id":"ENSMUSP00000071984","abundance":23.1,"rank":2620,"name":"Tmem65","annotation":"Transmembrane protein 65; May play an important role in cardiac development and function. May regulate cardiac conduction and the function of the gap junction protein GJA1. May contribute to the stability and proper localization of GJA1 to cardiac intercalated disk thereby regulating gap junction communication. Regulates mitochondrial respiration and mitochondrial DNA copy number maintenance (By similarity)."},{"id":"ENSMUSP00000104322","abundance":23.1,"rank":2621,"name":"Gas7","annotation":"Growth arrest-specific protein 7; May play a role in promoting maturation and morphological differentiation of cerebellar neurons."},{"id":"ENSMUSP00000133024","abundance":23,"rank":2622,"name":"Retn","annotation":"Resistin; Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes; Belongs to the resistin/FIZZ family."},{"id":"ENSMUSP00000048036","abundance":23,"rank":2623,"name":"Tubg1","annotation":"Tubulin gamma-1 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity)."},{"id":"ENSMUSP00000001780","abundance":23,"rank":2624,"name":"Akt1","annotation":"RAC-alpha serine/threonine-protein kinase; AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] "},{"id":"ENSMUSP00000014698","abundance":23,"rank":2625,"name":"Dguok","annotation":"Deoxyguanosine kinase, mitochondrial; Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine. In non-replicating cells, where cytosolic dNTP synthesis is down- regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs. Widely used as target of antiviral and chemotherapeutic agents."},{"id":"ENSMUSP00000043618","abundance":23,"rank":2626,"name":"Rprd1a","annotation":"Regulation of nuclear pre-mRNA domain-containing protein 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle; Belongs to the UPF0400 (RTT103) family."},{"id":"ENSMUSP00000043204","abundance":23,"rank":2627,"name":"Polr2l","annotation":"DNA-directed RNA polymerases I, II, and III subunit RPABC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of  [...] "},{"id":"ENSMUSP00000151918","abundance":22.9,"rank":2628,"name":"Cnpy2","annotation":"Protein canopy homolog 2; Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation (By similarity); Belongs to the canopy family."},{"id":"ENSMUSP00000113587","abundance":22.9,"rank":2629,"name":"Cops7b","annotation":"COP9 signalosome complex subunit 7b; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-de [...] "},{"id":"ENSMUSP00000031838","abundance":22.9,"rank":2630,"name":"Igf2bp3","annotation":"Insulin-like growth factor 2 mRNA-binding protein 3; RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta-actin/ACTB and MYC transcripts (By s [...] "},{"id":"ENSMUSP00000034441","abundance":22.9,"rank":2631,"name":"Aars","annotation":"Alanine--tRNA ligase, cytoplasmic; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain."},{"id":"ENSMUSP00000045945","abundance":22.9,"rank":2632,"name":"Ppig","annotation":"Peptidyl-prolyl cis-trans isomerase G; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing."},{"id":"ENSMUSP00000063412","abundance":22.9,"rank":2633,"name":"Acox3","annotation":"Peroxisomal acyl-coenzyme A oxidase 3; Oxidizes the CoA-esters of 2-methyl-branched fatty acids."},{"id":"ENSMUSP00000031003","abundance":22.9,"rank":2634,"name":"Ppp2r2c","annotation":"Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment."},{"id":"ENSMUSP00000076948","abundance":22.9,"rank":2635,"name":"Sag","annotation":"S-arrestin; Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells ; Belongs to the arrestin family."},{"id":"ENSMUSP00000075762","abundance":22.8,"rank":2636,"name":"Pmpca","annotation":"Mitochondrial-processing peptidase subunit alpha; Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins."},{"id":"ENSMUSP00000028307","abundance":22.8,"rank":2637,"name":"Fcna","annotation":"Ficolin-1; Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen- associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity)."},{"id":"ENSMUSP00000028102","abundance":22.8,"rank":2638,"name":"Kif5c","annotation":"Kinesin heavy chain isoform 5C; Involved in synaptic transmission (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Mediates dendritic trafficking of mRNAs. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity)."},{"id":"ENSMUSP00000064878","abundance":22.8,"rank":2639,"name":"Wnt5a","annotation":"Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferatio [...] "},{"id":"ENSMUSP00000041442","abundance":22.8,"rank":2640,"name":"Hsd3b5","annotation":"NADPH-dependent 3-keto-steroid reductase Hsd3b5; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase."},{"id":"ENSMUSP00000074448","abundance":22.8,"rank":2641,"name":"Lamp2","annotation":"Lysosome-associated membrane glycoprotein 2; Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the mos [...] "},{"id":"ENSMUSP00000023820","abundance":22.8,"rank":2642,"name":"Fabp2","annotation":"Fatty acid-binding protein, intestinal; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family."},{"id":"ENSMUSP00000034607","abundance":22.7,"rank":2643,"name":"Arcn1","annotation":"Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also inf [...] "},{"id":"ENSMUSP00000031897","abundance":22.7,"rank":2644,"name":"Gstk1","annotation":"Glutathione S-transferase kappa 1; Belongs to the GST superfamily. Kappa family."},{"id":"ENSMUSP00000003459","abundance":22.7,"rank":2645,"name":"Myo1g","annotation":"Unconventional myosin-Ig; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B- cells, where it regulates different membrane/cytoskeleton-dependent process [...] "},{"id":"ENSMUSP00000057771","abundance":22.7,"rank":2646,"name":"Rangap1","annotation":"Ran GTPase-activating protein 1; GTPase activator for RAN. Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export. Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (By similarity). Required for postimplantation embryonic development ; Belongs to the RNA1 family."},{"id":"ENSMUSP00000052262","abundance":22.7,"rank":2647,"name":"Vamp7","annotation":"Vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] "},{"id":"ENSMUSP00000085226","abundance":22.7,"rank":2648,"name":"Hdac8","annotation":"Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility (By similarity); Belongs to th [...] "},{"id":"ENSMUSP00000019882","abundance":22.7,"rank":2649,"name":"Polr2i","annotation":"DNA-directed RNA polymerase II subunit RPB9; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity)."},{"id":"ENSMUSP00000109611","abundance":22.7,"rank":2650,"name":"Gk","annotation":"Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism."},{"id":"ENSMUSP00000023161","abundance":22.6,"rank":2651,"name":"Srl","annotation":"Sarcalumenin; May be involved in the regulation of calcium transport."},{"id":"ENSMUSP00000038914","abundance":22.6,"rank":2652,"name":"Kmo","annotation":"Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract."},{"id":"ENSMUSP00000050034","abundance":22.6,"rank":2653,"name":"Dclk1","annotation":"Serine/threonine-protein kinase DCLK1; Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily."},{"id":"ENSMUSP00000027467","abundance":22.6,"rank":2654,"name":"Serpine2","annotation":"Glia-derived nexin; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin."},{"id":"ENSMUSP00000033012","abundance":22.5,"rank":2655,"name":"Copb1","annotation":"Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also infl [...] "},{"id":"ENSMUSP00000107347","abundance":22.5,"rank":2656,"name":"Tfpi","annotation":"Tissue factor pathway inhibitor; Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma (By similarity)."},{"id":"ENSMUSP00000022904","abundance":22.5,"rank":2657,"name":"Atp6v1c1","annotation":"V-type proton ATPase subunit C 1; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells."},{"id":"ENSMUSP00000045120","abundance":22.4,"rank":2658,"name":"S100g","annotation":"Protein S100-G; Belongs to the S-100 family."},{"id":"ENSMUSP00000029013","abundance":22.4,"rank":2659,"name":"Rae1","annotation":"mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton."},{"id":"ENSMUSP00000020898","abundance":22.4,"rank":2660,"name":"Agr2","annotation":"Anterior gradient protein 2 homolog; Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity). Promotes cell adhesion (By similarity); Belongs to the AGR family."},{"id":"ENSMUSP00000030851","abundance":22.3,"rank":2661,"name":"Tomm7","annotation":"Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity)."},{"id":"ENSMUSP00000029259","abundance":22.3,"rank":2662,"name":"Mccc1","annotation":"Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3- methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism."},{"id":"ENSMUSP00000039507","abundance":22.3,"rank":2663,"name":"Macrod1","annotation":"ADP-ribose glycohydrolase MACROD1; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed- forward  [...] "},{"id":"ENSMUSP00000095254","abundance":22.3,"rank":2664,"name":"Lrrfip1","annotation":"Leucine-rich repeat flightless-interacting protein 1; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA (By similarity). Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding (By similarity); Belongs to the LRRFIP family."},{"id":"ENSMUSP00000117347","abundance":22.2,"rank":2665,"name":"Erp29","annotation":"Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. Plays an important role in the processing of secretory proteins within the endoplasmic reticulum (ER), possibly by participating in the folding of proteins in the ER."},{"id":"ENSMUSP00000019726","abundance":22.2,"rank":2666,"name":"Plin3","annotation":"Perilipin-3; Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network; Belongs to the perilipin family."},{"id":"ENSMUSP00000032865","abundance":22.2,"rank":2667,"name":"Fah","annotation":"Fumarylacetoacetase; Belongs to the FAH family."},{"id":"ENSMUSP00000078746","abundance":22.2,"rank":2668,"name":"Stk24","annotation":"Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...] "},{"id":"ENSMUSP00000041839","abundance":22.2,"rank":2669,"name":"Txndc5","annotation":"Thioredoxin domain-containing protein 5; Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast."},{"id":"ENSMUSP00000113672","abundance":22.2,"rank":2670,"name":"Cth","annotation":"Cystathionine gamma-lyase; Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target protei [...] "},{"id":"ENSMUSP00000129584","abundance":22.2,"rank":2671,"name":"Bcar1","annotation":"Breast cancer anti-estrogen resistance protein 1; Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration (By similarity). Has been shown to be essential in cardiovascular development during embryogenesis. Belongs to the CAS family."},{"id":"ENSMUSP00000034946","abundance":22.2,"rank":2672,"name":"Snx1","annotation":"Sorting nexin-1; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] "},{"id":"ENSMUSP00000040694","abundance":22.2,"rank":2673,"name":"Rbpj","annotation":"Recombining binding protein suppressor of hairless; Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling  [...] "},{"id":"ENSMUSP00000125156","abundance":22.1,"rank":2674,"name":"Med6","annotation":"Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000046610","abundance":22.1,"rank":2675,"name":"Igfbp2","annotation":"Insulin-like growth factor-binding protein 2; Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors."},{"id":"ENSMUSP00000024906","abundance":22.1,"rank":2676,"name":"Twsg1","annotation":"Twisted gastrulation protein homolog 1; May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development."},{"id":"ENSMUSP00000110725","abundance":22.1,"rank":2677,"name":"Stag2","annotation":"Cohesin subunit SA-2; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity); Belongs to the SCC3 family."},{"id":"ENSMUSP00000001950","abundance":22.1,"rank":2678,"name":"Tollip","annotation":"Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity)."},{"id":"ENSMUSP00000067685","abundance":22.1,"rank":2679,"name":"Iqgap2","annotation":"Ras GTPase-activating-like protein IQGAP2; Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin."},{"id":"ENSMUSP00000118776","abundance":22.1,"rank":2680,"name":"Dpm1","annotation":"Dolichol-phosphate mannosyltransferase subunit 1; Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex."},{"id":"ENSMUSP00000034270","abundance":22.1,"rank":2681,"name":"Map1lc3b","annotation":"Microtubule-associated proteins 1A/1B light chain 3B; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellit [...] "},{"id":"ENSMUSP00000028004","abundance":22.1,"rank":2682,"name":"Aldh9a1","annotation":"4-trimethylaminobutyraldehyde dehydrogenase; Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency."},{"id":"ENSMUSP00000001156","abundance":22.1,"rank":2683,"name":"Cfp","annotation":"Properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes (By similarity). Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (By similarity)."},{"id":"ENSMUSP00000157842","abundance":22,"rank":2684,"name":"Atad1","annotation":"ATPase family AAA domain-containing protein 1; ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR), thereby regulating synaptic plasticity and learning and memory. Required for NMDA-stimulated AMPAR internalization and inhibition of GRIA1 and GRIA2 recycling back to the plasma membrane; these activities are ATPase-dependent."},{"id":"ENSMUSP00000090607","abundance":22,"rank":2685,"name":"Gm4952","annotation":"Glycine N-acyltransferase-like protein; Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity)."},{"id":"ENSMUSP00000006035","abundance":22,"rank":2686,"name":"Ergic3","annotation":"Endoplasmic reticulum-Golgi intermediate compartment protein 3; Possible role in transport between endoplasmic reticulum and Golgi."},{"id":"ENSMUSP00000029405","abundance":22,"rank":2687,"name":"Gmps","annotation":"GMP synthase [glutamine-hydrolyzing]; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division."},{"id":"ENSMUSP00000148807","abundance":22,"rank":2688,"name":"Cnot1","annotation":"CCR4-NOT transcription complex subunit 1; Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRN [...] "},{"id":"ENSMUSP00000044012","abundance":22,"rank":2689,"name":"Agl","annotation":"Amylo-1,6-glucosidase, 4-alpha-glucanotransferase."},{"id":"ENSMUSP00000031513","abundance":21.9,"rank":2690,"name":"Srsf9","annotation":"Serine/arginine-rich splicing factor 9; Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10 (By similarity); Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000085578","abundance":21.9,"rank":2691,"name":"Actr3b","annotation":"Actin-related protein 3B; Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors (By similarity); Belongs to the actin family. ARP3 subfamily."},{"id":"ENSMUSP00000092769","abundance":21.9,"rank":2692,"name":"Dhtkd1","annotation":"Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)."},{"id":"ENSMUSP00000031673","abundance":21.9,"rank":2693,"name":"Gngt1","annotation":"Guanine nucleotide-binding protein G(T) subunit gamma-T1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000028250","abundance":21.9,"rank":2694,"name":"Mrrf","annotation":"Ribosome-recycling factor, mitochondrial; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity); Belongs to the RRF family."},{"id":"ENSMUSP00000000349","abundance":21.8,"rank":2695,"name":"Dbt","annotation":"2-oxoisovalerate dehydrogenase E2 component (dihydrolipoyl transacylase); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component."},{"id":"ENSMUSP00000120466","abundance":21.8,"rank":2696,"name":"Plgrkt","annotation":"Plasminogen receptor (KT); Receptor for plasminogen. Regulates urokinase plasminogen activator-dependent and stimulates tissue-type plasminogen activator- dependent cell surface plasminogen activation. Proposed to be part of a local catecholaminergic cell plasminogen activation system that regulates neuroendocrine prohormone processing. Involved in regulation of inflammatory response; regulates monocyte chemotactic migration and matrix metalloproteinase activation, such as of MMP2 and MMP9."},{"id":"ENSMUSP00000144954","abundance":21.8,"rank":2697,"name":"Rfc1","annotation":"Replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction."},{"id":"ENSMUSP00000029446","abundance":21.8,"rank":2698,"name":"Csde1","annotation":"Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity)."},{"id":"ENSMUSP00000069081","abundance":21.8,"rank":2699,"name":"Gnpda1","annotation":"Glucosamine-6-phosphate isomerase 1; Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity)."},{"id":"ENSMUSP00000107743","abundance":21.8,"rank":2700,"name":"Hccs","annotation":"Cytochrome c-type heme lyase; Links covalently the heme group to the apoprotein of cytochrome c."},{"id":"ENSMUSP00000044361","abundance":21.8,"rank":2701,"name":"Smarca5","annotation":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5; Helicase that possesses intrinsic ATP-dependent nucleosome- remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. [...] "},{"id":"ENSMUSP00000109140","abundance":21.6,"rank":2702,"name":"Wdfy1","annotation":"WD repeat and FYVE domain-containing protein 1; Positively regulates TLR3- and TLR4-mediated signaling pathways by bridging the interaction between TLR3 or TLR4 and TICAM1. Promotes TLR3/4 ligand-induced activation of transcription factors IRF3 and NF-kappa-B, as well as the production of IFN-beta and inflammatory cytokines."},{"id":"ENSMUSP00000029024","abundance":21.6,"rank":2703,"name":"Rab22a","annotation":"Ras-related protein Rab-22A; Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes. Required for NGF- mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (By similarity). Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000029214","abundance":21.6,"rank":2704,"name":"Actl6a","annotation":"Actin-like protein 6A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remo [...] "},{"id":"ENSMUSP00000030117","abundance":21.6,"rank":2705,"name":"Smu1","annotation":"WD40 repeat-containing protein SMU1, N-terminally processed; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). Belongs to the WD repeat SMU1 family."},{"id":"ENSMUSP00000072800","abundance":21.6,"rank":2706,"name":"Cxcl12","annotation":"Stromal cell-derived factor 1; Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migrat [...] "},{"id":"ENSMUSP00000066621","abundance":21.6,"rank":2707,"name":"Glrx3","annotation":"Glutaredoxin-3; Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. Required for hemoglobin maturation. Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity)."},{"id":"ENSMUSP00000036921","abundance":21.6,"rank":2708,"name":"Pik3ip1","annotation":"Phosphoinositide-3-kinase-interacting protein 1; Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity."},{"id":"ENSMUSP00000158269","abundance":21.6,"rank":2709,"name":"Cbs","annotation":"Cystathionine beta-synthase; Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L- homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity)."},{"id":"ENSMUSP00000019229","abundance":21.6,"rank":2710,"name":"Med8","annotation":"Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a targ [...] "},{"id":"ENSMUSP00000072669","abundance":21.6,"rank":2711,"name":"Armc10","annotation":"Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53 (By similarity)."},{"id":"ENSMUSP00000131991","abundance":21.5,"rank":2712,"name":"Tnnc1","annotation":"Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments."},{"id":"ENSMUSP00000099520","abundance":21.5,"rank":2713,"name":"Nppa","annotation":"Atrial natriuretic factor; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3."},{"id":"ENSMUSP00000034539","abundance":21.5,"rank":2714,"name":"Dcps","annotation":"m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not h [...] "},{"id":"ENSMUSP00000032402","abundance":21.5,"rank":2715,"name":"Bcat1","annotation":"Branched-chain-amino-acid aminotransferase, cytosolic; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine."},{"id":"ENSMUSP00000005493","abundance":21.5,"rank":2716,"name":"Slc1a3","annotation":"Excitatory amino acid transporter 1; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate."},{"id":"ENSMUSP00000011492","abundance":21.5,"rank":2717,"name":"Acad9","annotation":"Complex I assembly factor ACAD9, mitochondrial; As part of the MCIA complex, primarily participates to the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation. This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs. However, in vivo, it does not seem to play a primary role in fatty acid oxidation. In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein."},{"id":"ENSMUSP00000090177","abundance":21.5,"rank":2718,"name":"Smurf2","annotation":"E3 ubiquitin-protein ligase SMURF2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as  [...] "},{"id":"ENSMUSP00000152412","abundance":21.5,"rank":2719,"name":"Gtpbp4","annotation":"Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit."},{"id":"ENSMUSP00000158318","abundance":21.5,"rank":2720,"name":"Tm9sf3","annotation":"Transmembrane 9 superfamily member 3."},{"id":"ENSMUSP00000068174","abundance":21.5,"rank":2721,"name":"Impa1","annotation":"Inositol monophosphatase 1; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4- diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta- glycerophosphate, and 2'-AMP as substrates."},{"id":"ENSMUSP00000033797","abundance":21.4,"rank":2722,"name":"Morf4l2","annotation":"Mortality factor 4-like protein 2; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] "},{"id":"ENSMUSP00000079543","abundance":21.4,"rank":2723,"name":"Lypd3","annotation":"Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression (By similarity)."},{"id":"ENSMUSP00000021447","abundance":21.4,"rank":2724,"name":"Ppp2r5e","annotation":"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Interacts with cyclin G in vitro."},{"id":"ENSMUSP00000023760","abundance":21.4,"rank":2725,"name":"Gpd1","annotation":"Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic."},{"id":"ENSMUSP00000010550","abundance":21.4,"rank":2726,"name":"Mrpl52","annotation":"39S ribosomal protein L52, mitochondrial."},{"id":"ENSMUSP00000004955","abundance":21.4,"rank":2727,"name":"Prpsap2","annotation":"Phosphoribosyl pyrophosphate synthase-associated protein 2; Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis; Belongs to the ribose-phosphate pyrophosphokinase family."},{"id":"ENSMUSP00000031625","abundance":21.4,"rank":2728,"name":"Arpc1a","annotation":"Actin-related protein 2/3 complex subunit 1A; Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (By similarity)."},{"id":"ENSMUSP00000025598","abundance":21.3,"rank":2729,"name":"Keg1","annotation":"Glycine N-acyltransferase-like protein Keg1; Acyltransferase which transfers the acyl group to the N- terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines (By similarity)."},{"id":"ENSMUSP00000141227","abundance":21.3,"rank":2730,"name":"Kpna4","annotation":"Importin subunit alpha-3; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] "},{"id":"ENSMUSP00000027071","abundance":21.3,"rank":2731,"name":"Lactb2","annotation":"Endoribonuclease LACTB2; Endoribonuclease; cleaves preferentially 3' to purine- pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double- stranded RNA or DNA. Required for normal mitochondrial function and cell viability; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family."},{"id":"ENSMUSP00000092487","abundance":21.3,"rank":2732,"name":"Cyp4a12b","annotation":"Cytochrome P450 4A12B; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega- oxidation) of saturated and unsaturated fatty acids. May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney. Participates [...] "},{"id":"ENSMUSP00000055886","abundance":21.3,"rank":2733,"name":"Gm10681","annotation":"NADPH-dependent 3-keto-steroid reductase Hsd3b4; Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Does not function as an isomerase. Belongs to the 3-beta-HSD family."},{"id":"ENSMUSP00000142522","abundance":21.3,"rank":2734,"name":"Hsd3b4","annotation":"Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 4."},{"id":"ENSMUSP00000029303","abundance":21.2,"rank":2735,"name":"Naa15","annotation":"N-alpha-acetyltransferase 15, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity. The NAT activity may be important for vascular, hematopoietic and neuronal growth and development. Required to control retinal neovascularization in adult ocular endothelial cells. In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter."},{"id":"ENSMUSP00000005185","abundance":21.2,"rank":2736,"name":"Cstb","annotation":"Cystatin-B; This is an intracellular thiol proteinase inhibitor."},{"id":"ENSMUSP00000121182","abundance":21.2,"rank":2737,"name":"Faf2","annotation":"FAS-associated factor 2; Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady- state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis."},{"id":"ENSMUSP00000019378","abundance":21.2,"rank":2738,"name":"Mlh3","annotation":"MutL homolog 3 (E coli)."},{"id":"ENSMUSP00000025490","abundance":21.2,"rank":2739,"name":"Prrc1","annotation":"Protein PRRC1."},{"id":"ENSMUSP00000105587","abundance":21.2,"rank":2740,"name":"Nxt1","annotation":"NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (By similarity)."},{"id":"ENSMUSP00000120075","abundance":21.2,"rank":2741,"name":"Mrps14","annotation":"28S ribosomal protein S14, mitochondrial; Belongs to the universal ribosomal protein uS14 family."},{"id":"ENSMUSP00000015920","abundance":21.2,"rank":2742,"name":"Med22","annotation":"Mediator of RNA polymerase II transcription subunit 22; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000029663","abundance":21.1,"rank":2743,"name":"Aimp1","annotation":"Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (By similarity). Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated reten [...] "},{"id":"ENSMUSP00000071064","abundance":21.1,"rank":2744,"name":"Cyp2d12","annotation":"Cytochrome P450, family 2, subfamily d, polypeptide 12; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000024078","abundance":21.1,"rank":2745,"name":"March5","annotation":"E3 ubiquitin-protein ligase MARCHF5; Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1."},{"id":"ENSMUSP00000025204","abundance":21.1,"rank":2746,"name":"Pfdn1","annotation":"Prefoldin subunit 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity); Belongs to the prefoldin subunit beta family."},{"id":"ENSMUSP00000016977","abundance":21.1,"rank":2747,"name":"Mrps18c","annotation":"28S ribosomal protein S18c, mitochondrial; Belongs to the bacterial ribosomal protein bS18 family."},{"id":"ENSMUSP00000100059","abundance":21.1,"rank":2748,"name":"Ufl1","annotation":"E3 UFM1-protein ligase 1; E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling. May also play a role in nuclear receptor-mediated transcription through TRIP4 ufmylation. May play a role in the unfolded protein response, mediating the ufmylation of multip [...] "},{"id":"ENSMUSP00000104938","abundance":21.1,"rank":2749,"name":"Nln","annotation":"Neurolysin, mitochondrial; Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A; Belongs to the peptidase M3 family."},{"id":"ENSMUSP00000023083","abundance":21.1,"rank":2750,"name":"Cyp2d22","annotation":"Cytochrome P450, family 2, subfamily d, polypeptide 22; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000039243","abundance":21,"rank":2751,"name":"Snx2","annotation":"Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] "},{"id":"ENSMUSP00000028617","abundance":21,"rank":2752,"name":"Api5","annotation":"Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity)."},{"id":"ENSMUSP00000028162","abundance":21,"rank":2753,"name":"Ptges2","annotation":"Prostaglandin E synthase 2 truncated form; Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (By similarity). May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear."},{"id":"ENSMUSP00000043190","abundance":21,"rank":2754,"name":"Gna11","annotation":"Guanine nucleotide-binding protein subunit alpha-11; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C."},{"id":"ENSMUSP00000028398","abundance":21,"rank":2755,"name":"Ube2e3","annotation":"Ubiquitin-conjugating enzyme E2 E3; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination (By similarity). Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest."},{"id":"ENSMUSP00000099544","abundance":21,"rank":2756,"name":"Hspb7","annotation":"Heat shock protein beta-7."},{"id":"ENSMUSP00000003726","abundance":21,"rank":2757,"name":"Brd4","annotation":"Bromodomain-containing protein 4; Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and rec [...] "},{"id":"ENSMUSP00000020856","abundance":21,"rank":2758,"name":"Bzw2","annotation":"Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation."},{"id":"ENSMUSP00000099632","abundance":21,"rank":2759,"name":"Asgr2","annotation":"Asialoglycoprotein receptor 2; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface."},{"id":"ENSMUSP00000047353","abundance":21,"rank":2760,"name":"Atp1b2","annotation":"Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known."},{"id":"ENSMUSP00000025778","abundance":20.9,"rank":2761,"name":"Gldc","annotation":"Glycine dehydrogenase (decarboxylating), mitochondrial; The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). Belongs to the GcvP family."},{"id":"ENSMUSP00000016680","abundance":20.9,"rank":2762,"name":"Cul4a","annotation":"Cullin-4A; Core component of multiple cullin-RING-based E3 ubiquitin- protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin- protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends  [...] "},{"id":"ENSMUSP00000070957","abundance":20.9,"rank":2763,"name":"Ash2l","annotation":"Set1/Ash2 histone methyltransferase complex subunit ASH2; Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis (By similarity). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B  [...] "},{"id":"ENSMUSP00000104408","abundance":20.9,"rank":2764,"name":"Rgs19","annotation":"Regulator of G-protein signaling 19; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity)."},{"id":"ENSMUSP00000037754","abundance":20.9,"rank":2765,"name":"AI182371","annotation":"Expressed sequence AI182371."},{"id":"ENSMUSP00000034304","abundance":20.9,"rank":2766,"name":"Hsd17b2","annotation":"Estradiol 17-beta-dehydrogenase 2; Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha- HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity)."},{"id":"ENSMUSP00000017841","abundance":20.9,"rank":2767,"name":"Ada","annotation":"Adenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity) [...] "},{"id":"ENSMUSP00000025997","abundance":20.9,"rank":2768,"name":"Smndc1","annotation":"Survival of motor neuron-related-splicing factor 30; Necessary for spliceosome assembly. Overexpression causes apoptosis (By similarity); Belongs to the SMN family."},{"id":"ENSMUSP00000133008","abundance":20.8,"rank":2769,"name":"Cd36","annotation":"Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependen [...] "},{"id":"ENSMUSP00000021689","abundance":20.8,"rank":2770,"name":"Evl","annotation":"Ena/VASP-like protein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization."},{"id":"ENSMUSP00000131316","abundance":20.8,"rank":2771,"name":"Hspg2","annotation":"Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity). The LG3 peptide has anti-angiogenic propert [...] "},{"id":"ENSMUSP00000022437","abundance":20.8,"rank":2772,"name":"Hacl1","annotation":"2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2- hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde."},{"id":"ENSMUSP00000075089","abundance":20.8,"rank":2773,"name":"Upf1","annotation":"Regulator of nonsense transcripts 1; RNA-dependent helicase and ATPase required for nonsense- mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. Recruited by release factors to stalled ribosomes together with the SMG1C protein kinase complex to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction complex (EJC) (located 50-55 or more n [...] "},{"id":"ENSMUSP00000084799","abundance":20.8,"rank":2774,"name":"Nif3l1","annotation":"NIF3-like protein 1; May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation."},{"id":"ENSMUSP00000137585","abundance":20.8,"rank":2775,"name":"Col6a3","annotation":"Collagen, type VI, alpha 3."},{"id":"ENSMUSP00000077972","abundance":20.8,"rank":2776,"name":"Grsf1","annotation":"G-rich sequence factor 1; Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G- rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome- mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwindi [...] "},{"id":"ENSMUSP00000146245","abundance":20.8,"rank":2777,"name":"Ppp4c","annotation":"Serine/threonine-protein phosphatase 4 catalytic subunit; Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2- PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphor [...] "},{"id":"ENSMUSP00000057989","abundance":20.7,"rank":2778,"name":"Bdnf","annotation":"Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentia [...] "},{"id":"ENSMUSP00000032761","abundance":20.7,"rank":2779,"name":"Pex11a","annotation":"Peroxisomal membrane protein 11A; May be involved in peroxisomal proliferation and may regulate peroxisomes division. May mediate binding of coatomer proteins to the peroxisomal membrane (By similarity). Promotes membrane protrusion and elongation on the peroxisomal surface; Belongs to the peroxin-11 family."},{"id":"ENSMUSP00000030884","abundance":20.7,"rank":2780,"name":"Mfn2","annotation":"Mitofusin-2; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation  [...] "},{"id":"ENSMUSP00000043111","abundance":20.7,"rank":2781,"name":"Rpl22l1","annotation":"60S ribosomal protein L22-like 1."},{"id":"ENSMUSP00000095015","abundance":20.7,"rank":2782,"name":"Tcp10c","annotation":"T-complex protein 10c."},{"id":"ENSMUSP00000076899","abundance":20.7,"rank":2783,"name":"Mup21","annotation":"Major urinary protein 21; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000156862","abundance":20.6,"rank":2784,"name":"Ptp4a1-2","annotation":"Protein tyrosine phosphatase 4a1."},{"id":"ENSMUSP00000027232","abundance":20.6,"rank":2785,"name":"Ptp4a1","annotation":"Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity)."},{"id":"ENSMUSP00000092223","abundance":20.6,"rank":2786,"name":"Map1a","annotation":"Microtubule-associated protein 1A; Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements; Belongs to the MAP1 family."},{"id":"ENSMUSP00000035884","abundance":20.6,"rank":2787,"name":"Cops8","annotation":"COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- [...] "},{"id":"ENSMUSP00000026050","abundance":20.6,"rank":2788,"name":"Gsto1","annotation":"Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family."},{"id":"ENSMUSP00000078741","abundance":20.6,"rank":2789,"name":"Notch2","annotation":"Neurogenic locus notch homolog protein 2; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation (By  [...] "},{"id":"ENSMUSP00000031251","abundance":20.6,"rank":2790,"name":"Hsd17b11","annotation":"Estradiol 17-beta-dehydrogenase 11; Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A- dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily."},{"id":"ENSMUSP00000129593","abundance":20.6,"rank":2791,"name":"Defa33","annotation":"Defensin, alpha, 33."},{"id":"ENSMUSP00000081054","abundance":20.6,"rank":2792,"name":"Defa32","annotation":"Alpha-defensin 20; May have microbicidal activities; Belongs to the alpha-defensin family."},{"id":"ENSMUSP00000081055","abundance":20.6,"rank":2793,"name":"Defa20","annotation":"Defensin, alpha, 20."},{"id":"ENSMUSP00000125888","abundance":20.6,"rank":2794,"name":"Defa2","annotation":"Defensin, alpha, 33."},{"id":"ENSMUSP00000110906","abundance":20.6,"rank":2795,"name":"Tnpo3","annotation":"Transportin-3; Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and t [...] "},{"id":"ENSMUSP00000001884","abundance":20.5,"rank":2796,"name":"Clpb","annotation":"Caseinolytic peptidase B protein homolog; May function as a regulatory ATPase and be related to secretion/protein trafficking process; Belongs to the ClpA/ClpB family."},{"id":"ENSMUSP00000025421","abundance":20.5,"rank":2797,"name":"Seh1l","annotation":"Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore."},{"id":"ENSMUSP00000030660","abundance":20.5,"rank":2798,"name":"Trappc3","annotation":"Trafficking protein particle complex subunit 3; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily."},{"id":"ENSMUSP00000106983","abundance":20.5,"rank":2799,"name":"Uap1","annotation":"UDP-N-acetylgalactosamine pyrophosphorylase; Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P (By similarity)."},{"id":"ENSMUSP00000009699","abundance":20.5,"rank":2800,"name":"Cdk9","annotation":"Cyclin-dependent kinase 9; Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR and the negative elongation factors DSIF and NELF. Regulates cytoki [...] "},{"id":"ENSMUSP00000096690","abundance":20.5,"rank":2801,"name":"Slc12a5","annotation":"Solute carrier family 12 member 5; Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition. Involved in the regulation of dendritic spine formation and maturation; Belongs to the SLC12A transporter family."},{"id":"ENSMUSP00000031597","abundance":20.4,"rank":2802,"name":"Plbd2","annotation":"Putative phospholipase B-like 2 15 kDa form; Putative phospholipase."},{"id":"ENSMUSP00000038716","abundance":20.4,"rank":2803,"name":"Gm49336","annotation":"Nucleoporin p58/p45; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Belongs to the NUP58 family."},{"id":"ENSMUSP00000020904","abundance":20.4,"rank":2804,"name":"Rock2","annotation":"Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] "},{"id":"ENSMUSP00000057732","abundance":20.4,"rank":2805,"name":"Rdh9","annotation":"Cis-retinol/androgen dehydrogenase type 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000127646","abundance":20.4,"rank":2806,"name":"Arsa","annotation":"Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family."},{"id":"ENSMUSP00000099990","abundance":20.4,"rank":2807,"name":"Anp32b","annotation":"Acidic leucine-rich nuclear phosphoprotein 32 family member B; Multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Required for the progression from the G1 to the S phase. Anti-apoptotic protein which functions as a caspase-3 inhibitor. Has no phosphatase 2A (PP2A) inhibitor activity. Exhibits histone chaperone properties, stimulating core histones to assemble into a nucleosome (By similarity); Belongs to the ANP32 family."},{"id":"ENSMUSP00000043513","abundance":20.4,"rank":2808,"name":"Sprr2i","annotation":"Small proline-rich protein 2I; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)."},{"id":"ENSMUSP00000064652","abundance":20.4,"rank":2809,"name":"Sprr2e","annotation":"Small proline-rich protein 2E; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)."},{"id":"ENSMUSP00000139654","abundance":20.4,"rank":2810,"name":"Spcs1","annotation":"Signal peptidase complex subunit 1; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum."},{"id":"ENSMUSP00000133276","abundance":20.4,"rank":2811,"name":"Prdx6b","annotation":"Peroxiredoxin 6, related sequence 1."},{"id":"ENSMUSP00000109304","abundance":20.4,"rank":2812,"name":"Drap1","annotation":"Dr1-associated corepressor; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity). Belongs to the NC2 alpha/DRAP1 family."},{"id":"ENSMUSP00000001716","abundance":20.3,"rank":2813,"name":"Ddt","annotation":"D-dopachrome decarboxylase; Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI); Belongs to the MIF family."},{"id":"ENSMUSP00000050902","abundance":20.3,"rank":2814,"name":"Sprr2f","annotation":"Small proline-rich protein 2F; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane (By similarity)."},{"id":"ENSMUSP00000026506","abundance":20.3,"rank":2815,"name":"Clns1a","annotation":"Methylosome subunit pICln; Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cyto [...] "},{"id":"ENSMUSP00000027752","abundance":20.3,"rank":2816,"name":"Lamc1","annotation":"Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."},{"id":"ENSMUSP00000062092","abundance":20.2,"rank":2817,"name":"Sntn","annotation":"Sentan; May be a component of the linker structure that bridges the ciliary membrane and peripheral singlet microtubules."},{"id":"ENSMUSP00000034058","abundance":20.2,"rank":2818,"name":"Cbr4","annotation":"Carbonyl reductase family member 4; The heterotetramer with HSD17B8 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD. The homotetramer has NADPH-dependent quinone reductase activity. Both homotetramer and the heterotetramer have broad in vitro substrate specificity and can reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o- quinones and p-quinones; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000073869","abundance":20.2,"rank":2819,"name":"Krt40","annotation":"Keratin, type I cytoskeletal 40; May play a role in late hair differentiation."},{"id":"ENSMUSP00000063042","abundance":20.2,"rank":2820,"name":"Tpra1","annotation":"Transmembrane protein adipocyte-associated 1."},{"id":"ENSMUSP00000127709","abundance":20.2,"rank":2821,"name":"Fam3c","annotation":"Protein FAM3C; May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition."},{"id":"ENSMUSP00000099642","abundance":20.2,"rank":2822,"name":"Acacb","annotation":"Acetyl-CoA carboxylase 2; Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (By similarity). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (By similarity). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation. Together [...] "},{"id":"ENSMUSP00000030830","abundance":20.2,"rank":2823,"name":"H6pd","annotation":"GDH/6PGL endoplasmic bifunctional protein; Bifunctional enzyme localized in the lumen of the endoplasmic reticulum that catalyzes the first two steps of the oxidative branch of the pentose phosphate pathway/shunt, an alternative to glycolysis and a major source of reducing power and metabolic intermediates for biosynthetic processes. Has a hexose-6-phosphate dehydrogenase activity, with broad substrate specificity compared to glucose-6-phosphate 1-dehydrogenase/G6PD, and catalyzes the first step of the pentose phosphate pathway. In addition, acts as a 6-phosphogluconolactonase and cata [...] "},{"id":"ENSMUSP00000057563","abundance":20.2,"rank":2824,"name":"Gp1ba","annotation":"Platelet glycoprotein Ib alpha chain; GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium."},{"id":"ENSMUSP00000123088","abundance":20.2,"rank":2825,"name":"Myef2","annotation":"Myelin expression factor 2; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA."},{"id":"ENSMUSP00000068931","abundance":20.2,"rank":2826,"name":"Mta3","annotation":"Metastasis-associated protein MTA3; Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 (By similarity)."},{"id":"ENSMUSP00000038971","abundance":20.2,"rank":2827,"name":"Mfap4","annotation":"Microfibril-associated glycoprotein 4; Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance."},{"id":"ENSMUSP00000147093","abundance":20.1,"rank":2828,"name":"Kcnb1","annotation":"Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function (By sim [...] "},{"id":"ENSMUSP00000102636","abundance":20.1,"rank":2829,"name":"Hsd3b2","annotation":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids."},{"id":"ENSMUSP00000109574","abundance":20.1,"rank":2830,"name":"Brd3","annotation":"Bromodomain-containing protein 3; Chromatin reader that recognizes and binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets."},{"id":"ENSMUSP00000045841","abundance":20.1,"rank":2831,"name":"Eprs","annotation":"Bifunctional glutamate/proline--tRNA ligase; Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (By similarity). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex  [...] "},{"id":"ENSMUSP00000060900","abundance":20.1,"rank":2832,"name":"Trnt1","annotation":"CCA tRNA nucleotidyltransferase 1, mitochondrial; Adds and repairs the conserved 3'-CCA sequence necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family."},{"id":"ENSMUSP00000070751","abundance":20.1,"rank":2833,"name":"Bsg","annotation":"Basigin; Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes."},{"id":"ENSMUSP00000029803","abundance":20.1,"rank":2834,"name":"Eif4e","annotation":"Eukaryotic translation initiation factor 4E; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage-specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translat [...] "},{"id":"ENSMUSP00000129828","abundance":20.1,"rank":2835,"name":"Farsb","annotation":"Phenylalanine--tRNA ligase beta subunit."},{"id":"ENSMUSP00000023055","abundance":20.1,"rank":2836,"name":"Dnal4","annotation":"Dynein light chain 4, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity)."},{"id":"ENSMUSP00000030578","abundance":20,"rank":2837,"name":"Ptp4a2","annotation":"Protein tyrosine phosphatase type IVA 2; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity)."},{"id":"ENSMUSP00000005711","abundance":20,"rank":2838,"name":"Chmp2a","annotation":"Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] "},{"id":"ENSMUSP00000103981","abundance":20,"rank":2839,"name":"Akt2","annotation":"RAC-beta serine/threonine-protein kinase; AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinases, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the [...] "},{"id":"ENSMUSP00000026520","abundance":20,"rank":2840,"name":"Paip1","annotation":"Polyadenylate-binding protein-interacting protein 1; Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA- binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant o [...] "},{"id":"ENSMUSP00000034541","abundance":20,"rank":2841,"name":"Srpr","annotation":"Signal recognition particle receptor subunit alpha; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity)."},{"id":"ENSMUSP00000002885","abundance":20,"rank":2842,"name":"Epdr1","annotation":"Mammalian ependymin-related protein 1; Binds anionic lipids and gangliosides at acidic pH. Belongs to the ependymin family."},{"id":"ENSMUSP00000130722","abundance":20,"rank":2843,"name":"Mrpl13","annotation":"39S ribosomal protein L13, mitochondrial; Belongs to the universal ribosomal protein uL13 family."},{"id":"ENSMUSP00000130338","abundance":20,"rank":2844,"name":"Cyp2d11","annotation":"Cytochrome P450 2D11; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000068895","abundance":20,"rank":2845,"name":"Capn2","annotation":"Calpain-2 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs."},{"id":"ENSMUSP00000032539","abundance":19.9,"rank":2846,"name":"Slc27a5","annotation":"Bile acyl-CoA synthetase; Acyl-CoA synthetase that catalyzes the activation of bile acids via formation of bile acid CoA thioesters which is necessary for their subsequent conjugation with glycine or taurine. Catalyzes the activation of the primary bile acid, cholic acid. Both primary bile acid (chenodeoxycholic acid) and secondary bile acids (deoxycholic acid and lithocholic acid) are the principal substrates (By similarity). Also exhibits acyl CoA synthetase activity that activates very long-chain fatty acids (VLCFAs) by catalyzing the formation of fatty acyl-CoA (By similarity). In  [...] "},{"id":"ENSMUSP00000069488","abundance":19.9,"rank":2847,"name":"Ercc6l2","annotation":"DNA excision repair protein ERCC-6-like 2; May be involved in early DNA damage response."},{"id":"ENSMUSP00000099835","abundance":19.9,"rank":2848,"name":"Sqstm1","annotation":"Sequestosome-1; Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin- containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and  [...] "},{"id":"ENSMUSP00000028970","abundance":19.9,"rank":2849,"name":"Mylk2","annotation":"Myosin light chain kinase 2, skeletal/cardiac muscle; Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity)."},{"id":"ENSMUSP00000096159","abundance":19.8,"rank":2850,"name":"Krtdap","annotation":"Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity)."},{"id":"ENSMUSP00000021428","abundance":19.8,"rank":2851,"name":"Snw1","annotation":"SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1,  [...] "},{"id":"ENSMUSP00000028619","abundance":19.8,"rank":2852,"name":"Hsd17b12","annotation":"Very-long-chain 3-oxoacyl-CoA reductase; Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3- hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membra [...] "},{"id":"ENSMUSP00000058168","abundance":19.8,"rank":2853,"name":"Dcaf7","annotation":"DDB1- and CUL4-associated factor 7; Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity)."},{"id":"ENSMUSP00000151620","abundance":19.8,"rank":2854,"name":"Gja1","annotation":"Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization [...] "},{"id":"ENSMUSP00000072220","abundance":19.8,"rank":2855,"name":"Washc1","annotation":"WASH complex subunit 1; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting (By similarity). Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to- membran [...] "},{"id":"ENSMUSP00000157221","abundance":19.8,"rank":2856,"name":"Atp6v1e2","annotation":"V-type proton ATPase subunit E 2; Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome."},{"id":"ENSMUSP00000031978","abundance":19.7,"rank":2857,"name":"Mrps33","annotation":"28S ribosomal protein S33, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS33 family."},{"id":"ENSMUSP00000092148","abundance":19.7,"rank":2858,"name":"Nfasc","annotation":"Neurofascin; Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions; Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family."},{"id":"ENSMUSP00000114402","abundance":19.7,"rank":2859,"name":"Mrps25","annotation":"28S ribosomal protein S25, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS25 family."},{"id":"ENSMUSP00000157520","abundance":19.7,"rank":2860,"name":"Tkfc","annotation":"ATP-dependent dihydroxyacetone kinase; Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1- mediated cellular antiviral response."},{"id":"ENSMUSP00000020535","abundance":19.7,"rank":2861,"name":"Hbq1a","annotation":"Hemoglobin, theta 1A; Belongs to the globin family."},{"id":"ENSMUSP00000127076","abundance":19.7,"rank":2862,"name":"Sap25","annotation":"Histone deacetylase complex subunit SAP25; Involved in the transcriptional repression mediated by the mSIN3A but not the N-CoR corepressor complex."},{"id":"ENSMUSP00000021028","abundance":19.7,"rank":2863,"name":"Itgb3","annotation":"Integrin beta-3; Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIB/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIB/beta-3 and alpha- V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIB/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A- G-D-V in fibrinogen gamma chain. Following ac [...] "},{"id":"ENSMUSP00000049000","abundance":19.7,"rank":2864,"name":"Ndufv3","annotation":"NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I."},{"id":"ENSMUSP00000046585","abundance":19.7,"rank":2865,"name":"Acsl5","annotation":"Long-chain-fatty-acid--CoA ligase 5; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAI [...] "},{"id":"ENSMUSP00000030381","abundance":19.7,"rank":2866,"name":"Ctps","annotation":"CTP synthase 1; This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity."},{"id":"ENSMUSP00000081263","abundance":19.7,"rank":2867,"name":"Wasf2","annotation":"Wiskott-Aldrich syndrome protein family member 2; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity)."},{"id":"ENSMUSP00000109815","abundance":19.7,"rank":2868,"name":"Chmp3","annotation":"Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] "},{"id":"ENSMUSP00000095197","abundance":19.7,"rank":2869,"name":"Lars","annotation":"Leucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs; Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000022589","abundance":19.7,"rank":2870,"name":"Enox1","annotation":"Protein disulfide-thiol oxidoreductase; Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock (By similarity)."},{"id":"ENSMUSP00000025419","abundance":19.6,"rank":2871,"name":"Ppic","annotation":"Peptidyl-prolyl cis-trans isomerase C; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding."},{"id":"ENSMUSP00000018909","abundance":19.6,"rank":2872,"name":"Fxr2","annotation":"Fragile X mental retardation syndrome-related protein 2; RNA-binding protein; Belongs to the FMR1 family."},{"id":"ENSMUSP00000075255","abundance":19.6,"rank":2873,"name":"Ugt2b37","annotation":"UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000139226","abundance":19.6,"rank":2874,"name":"Lrrc1","annotation":"Leucine-rich repeat-containing protein 1."},{"id":"ENSMUSP00000131371","abundance":19.6,"rank":2875,"name":"Rbms3","annotation":"RNA-binding motif, single-stranded-interacting protein 3; Binds poly(A) and poly(U) oligoribonucleotides."},{"id":"ENSMUSP00000080221","abundance":19.6,"rank":2876,"name":"Scoc","annotation":"Short coiled-coil protein; Positive regulator of amino acid starvation-induced autophagy; Belongs to the SCOC family."},{"id":"ENSMUSP00000038137","abundance":19.6,"rank":2877,"name":"Thoc6","annotation":"THO complex subunit 6 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.Plays a role in apoptosis neg [...] "},{"id":"ENSMUSP00000112782","abundance":19.6,"rank":2878,"name":"Kif3a","annotation":"Kinesin-like protein KIF3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole."},{"id":"ENSMUSP00000099609","abundance":19.6,"rank":2879,"name":"Mtfr1l","annotation":"Mitochondrial fission regulator 1-like."},{"id":"ENSMUSP00000019246","abundance":19.6,"rank":2880,"name":"Aldh3a1","annotation":"Aldehyde dehydrogenase, dimeric NADP-preferring; ALDHs play a major role in the detoxification of alcohol- derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids. Preferentially oxidizes aromatic aldehyde substrates. Comprises about 50 percent of corneal epithelial soluble proteins. May play a role in preventing corneal damage caused by ultraviolet light."},{"id":"ENSMUSP00000098936","abundance":19.6,"rank":2881,"name":"Hbq1b","annotation":"Hemoglobin, theta 1B; Belongs to the globin family."},{"id":"ENSMUSP00000028408","abundance":19.5,"rank":2882,"name":"Hat1","annotation":"Histone acetyltransferase type B catalytic subunit; Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes; Belongs to the HAT1 family."},{"id":"ENSMUSP00000146685","abundance":19.5,"rank":2883,"name":"Dmbt1","annotation":"Deleted in malignant brain tumors 1 protein; May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract (By similarity). Required for terminal differentiation of [...] "},{"id":"ENSMUSP00000128318","abundance":19.5,"rank":2884,"name":"Igfbp7","annotation":"Insulin-like growth factor-binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion (By similarity)."},{"id":"ENSMUSP00000037819","abundance":19.5,"rank":2885,"name":"Myo1d","annotation":"Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity)."},{"id":"ENSMUSP00000081021","abundance":19.5,"rank":2886,"name":"mt-Nd4l","annotation":"NADH-ubiquinone oxidoreductase chain 4L; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000078721","abundance":19.5,"rank":2887,"name":"Pcyt1a","annotation":"Choline-phosphate cytidylyltransferase A; Controls phosphatidylcholine synthesis; Belongs to the cytidylyltransferase family."},{"id":"ENSMUSP00000029325","abundance":19.4,"rank":2888,"name":"Aadac","annotation":"Arylacetamide deacetylase; Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly (By similarity). Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity."},{"id":"ENSMUSP00000132809","abundance":19.4,"rank":2889,"name":"Slc8a1","annotation":"Sodium/calcium exchanger 1; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage- gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] "},{"id":"ENSMUSP00000034703","abundance":19.4,"rank":2890,"name":"Carm1","annotation":"Histone-arginine methyltransferase CARM1; Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activ [...] "},{"id":"ENSMUSP00000030842","abundance":19.4,"rank":2891,"name":"Lzic","annotation":"Protein LZIC."},{"id":"ENSMUSP00000034435","abundance":19.4,"rank":2892,"name":"Ctrb1","annotation":"Chymotrypsin B chain A; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000132499","abundance":19.4,"rank":2893,"name":"Prkag1","annotation":"5'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a  [...] "},{"id":"ENSMUSP00000023713","abundance":19.4,"rank":2894,"name":"Krt82","annotation":"Keratin, type II cuticular Hb2; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000020886","abundance":19.4,"rank":2895,"name":"Nampt","annotation":"Nicotinamide phosphoribosyltransferase; The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma (By similarity). Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. Plays a role in the modulation of circ [...] "},{"id":"ENSMUSP00000136673","abundance":19.4,"rank":2896,"name":"Larp1","annotation":"La-related protein 1; RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif lead [...] "},{"id":"ENSMUSP00000035211","abundance":19.3,"rank":2897,"name":"Mst1","annotation":"Hepatocyte growth factor-like protein alpha chain."},{"id":"ENSMUSP00000026879","abundance":19.3,"rank":2898,"name":"Gdap1","annotation":"Ganglioside-induced differentiation-associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission; Belongs to the GST superfamily."},{"id":"ENSMUSP00000032342","abundance":19.3,"rank":2899,"name":"Mgp","annotation":"Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation."},{"id":"ENSMUSP00000106981","abundance":19.3,"rank":2900,"name":"Pacsin3","annotation":"Protein kinase C and casein kinase II substrate protein 3; Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity; Belongs to the PACSIN family."},{"id":"ENSMUSP00000029885","abundance":19.3,"rank":2901,"name":"Cpne3","annotation":"Copine-3; Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation; Belongs to the copine family."},{"id":"ENSMUSP00000049548","abundance":19.3,"rank":2902,"name":"Mfap1b","annotation":"Microfibrillar-associated protein 1A; Involved in pre-mRNA splicing as a component of the spliceosome."},{"id":"ENSMUSP00000087372","abundance":19.3,"rank":2903,"name":"Mfap1a","annotation":"Microfibrillar-associated protein 1A."},{"id":"ENSMUSP00000084791","abundance":19.3,"rank":2904,"name":"Lyar","annotation":"Cell growth-regulating nucleolar protein; Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity). Represses the expression of embryonic globin Hbb-y gene. In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity). Pref [...] "},{"id":"ENSMUSP00000107796","abundance":19.3,"rank":2905,"name":"Tspan9","annotation":"Tetraspanin-9; Belongs to the tetraspanin (TM4SF) family."},{"id":"ENSMUSP00000029888","abundance":19.3,"rank":2906,"name":"Rmdn1","annotation":"Regulator of microtubule dynamics protein 1; Belongs to the RMDN family."},{"id":"ENSMUSP00000056479","abundance":19.2,"rank":2907,"name":"9530053A07Rik","annotation":"RIKEN cDNA 9530053A07 gene."},{"id":"ENSMUSP00000093641","abundance":19.2,"rank":2908,"name":"Habp2","annotation":"Hyaluronan-binding protein 2 27 kDa light chain alternate form; Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII (By similarity); Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000026832","abundance":19.2,"rank":2909,"name":"Jmjd8","annotation":"JmjC domain-containing protein 8; Functions as a positive regulator of TNF-induced NF-kappaB signaling (By similarity). Regulates angiogenesis and cellular metabolism through interaction with PKM."},{"id":"ENSMUSP00000051709","abundance":19.2,"rank":2910,"name":"Asrgl1","annotation":"Isoaspartyl peptidase/L-asparaginase alpha chain; Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp- L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise,  [...] "},{"id":"ENSMUSP00000091487","abundance":19.1,"rank":2911,"name":"Supt4a","annotation":"Transcription elongation factor SPT4-A; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pa [...] "},{"id":"ENSMUSP00000026270","abundance":19.1,"rank":2912,"name":"Sacm1l","annotation":"Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 4-phosphate (PtdIns(4)P) (By similarity). Has low activity towards PtdIns(3,5)P2 (By similarity)."},{"id":"ENSMUSP00000107653","abundance":19.1,"rank":2913,"name":"Camp","annotation":"Cathelin-related antimicrobial peptide; Acts as a potent antimicrobial peptide."},{"id":"ENSMUSP00000108126","abundance":19.1,"rank":2914,"name":"Fam98a","annotation":"Protein FAM98A; Positively stimulates PRMT1-induced protein arginine methylation (By similarity). Involved in skeletal homeostasis. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts ; Belongs to the FAM98 family."},{"id":"ENSMUSP00000130532","abundance":19.1,"rank":2915,"name":"Ndufaf2","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2; Acts as a molecular chaperone for mitochondrial complex I assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000015712","abundance":19.1,"rank":2916,"name":"Lpl","annotation":"Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000036206","abundance":19.1,"rank":2917,"name":"Chmp4b","annotation":"Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] "},{"id":"ENSMUSP00000022169","abundance":19,"rank":2918,"name":"Hexb","annotation":"Beta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues."},{"id":"ENSMUSP00000080301","abundance":19,"rank":2919,"name":"Zc3h15","annotation":"Zinc finger CCCH domain-containing protein 15; Protects DRG1 from proteolytic degradation. Stimulates DRG1 GTPase activity likely by increasing the affinity for the potassium ions (By similarity)."},{"id":"ENSMUSP00000107609","abundance":19,"rank":2920,"name":"Taok3","annotation":"Serine/threonine-protein kinase TAO3; Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF) (By similarity [...] "},{"id":"ENSMUSP00000097349","abundance":19,"rank":2921,"name":"Lsamp","annotation":"Limbic system-associated membrane protein; Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity); Belongs to the immunoglobulin superfamily. IgLON family."},{"id":"ENSMUSP00000022915","abundance":19,"rank":2922,"name":"Dpys","annotation":"Dihydropyrimidinase; Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate (By similarity)."},{"id":"ENSMUSP00000099411","abundance":19,"rank":2923,"name":"Tgm2","annotation":"Protein-glutamine gamma-glutamyltransferase 2; Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins. Belongs to the transglutaminase superfamily. Transglutaminase family."},{"id":"ENSMUSP00000033995","abundance":19,"rank":2924,"name":"Rbpms","annotation":"RNA-binding protein with multiple splicing; Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA."},{"id":"ENSMUSP00000073371","abundance":19,"rank":2925,"name":"Lima1","annotation":"LIM domain and actin-binding protein 1; Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholest [...] "},{"id":"ENSMUSP00000157402","abundance":19,"rank":2926,"name":"Nars","annotation":"Asparagine--tRNA ligase, cytoplasmic; Catalyzes the attachment of asparagine to tRNA(Asn) in a two- step reaction: asparagine is first activated by ATP to form Asn-AMP and then transferred to the acceptor end of tRNA(Asn). In addition to its essential role in protein synthesis, acts as a signaling molecule that induces immune response in a CCR3-dependent manner."},{"id":"ENSMUSP00000030296","abundance":19,"rank":2927,"name":"Txndc12","annotation":"Thioredoxin domain-containing protein 12; Possesses significant protein thiol-disulfide oxidase activity."},{"id":"ENSMUSP00000123590","abundance":19,"rank":2928,"name":"Usp10","annotation":"Ubiquitin carboxyl-terminal hydrolase 10; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN [...] "},{"id":"ENSMUSP00000112283","abundance":19,"rank":2929,"name":"Mrpl39","annotation":"39S ribosomal protein L39, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL39 family."},{"id":"ENSMUSP00000078540","abundance":18.9,"rank":2930,"name":"Myo1a","annotation":"Unconventional myosin-Ia; Involved in directing the movement of organelles along actin filaments; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000033541","abundance":18.9,"rank":2931,"name":"Fundc2","annotation":"FUN14 domain-containing protein 2; Belongs to the FUN14 family."},{"id":"ENSMUSP00000093959","abundance":18.9,"rank":2932,"name":"Mta2","annotation":"Metastasis-associated protein MTA2; May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins."},{"id":"ENSMUSP00000002029","abundance":18.9,"rank":2933,"name":"Emd","annotation":"Emerin; Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta- catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1- dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non- farnesylated prelamin-A/C (By similarity)."},{"id":"ENSMUSP00000037808","abundance":18.9,"rank":2934,"name":"Ythdf1","annotation":"YTH domain-containing family protein 1; Specifically recognizes and binds N6-methyladenosine (m6A)- containing mRNAs, and promotes mRNA translation efficiency. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability. Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (By similarity). Required to facilitate learning and memory  [...] "},{"id":"ENSMUSP00000028608","abundance":18.9,"rank":2935,"name":"Nat10","annotation":"RNA cytidine acetyltransferase; RNA cytidine acetyltransferase that catalyzes the formation of N(4)-acetylcytidine (ac4C) modification on mRNAs, 18S rRNA and tRNAs. Catalyzes ac4C modification of a broad range of mRNAs, enhancing mRNA stability and translation. mRNA ac4C modification is frequently present within wobble cytidine sites and promotes translation efficiency. Mediates the formation of ac4C at position 1842 in 18S rRNA (By similarity). May also catalyze the formation of ac4C at position 1337 in 18S rRNA (By similarity). Required for early nucleolar cleavages of precursor rRNA [...] "},{"id":"ENSMUSP00000034827","abundance":18.8,"rank":2936,"name":"Imp3","annotation":"U3 small nucleolar ribonucleoprotein protein IMP3; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity)."},{"id":"ENSMUSP00000071573","abundance":18.8,"rank":2937,"name":"Rdh16","annotation":"Retinol dehydrogenase 16; Oxidoreductase with a preference for NAD. Oxidizes all-trans- retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction."},{"id":"ENSMUSP00000042009","abundance":18.8,"rank":2938,"name":"Bag2","annotation":"BAG family molecular chaperone regulator 2; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release."},{"id":"ENSMUSP00000045901","abundance":18.8,"rank":2939,"name":"Tubg2","annotation":"Tubulin gamma-2 chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity)."},{"id":"ENSMUSP00000038958","abundance":18.8,"rank":2940,"name":"Cpsf7","annotation":"Cleavage and polyadenylation specificity factor subunit 7; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The  [...] "},{"id":"ENSMUSP00000097874","abundance":18.8,"rank":2941,"name":"Prkcg","annotation":"Protein kinase C gamma type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing p [...] "},{"id":"ENSMUSP00000073555","abundance":18.8,"rank":2942,"name":"Fxyd7","annotation":"FXYD domain-containing ion transport regulator 7."},{"id":"ENSMUSP00000111510","abundance":18.8,"rank":2943,"name":"Glyr1","annotation":"Putative oxidoreductase GLYR1; Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Facilitates Pol II transcription through nucleosomes (By similarity). Binds DNA (in vitro) (By similarity). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3). Promotes KDM1B demethylase activity (By similarity). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (By similarity). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (By si [...] "},{"id":"ENSMUSP00000021347","abundance":18.8,"rank":2944,"name":"Sel1l","annotation":"Protein sel-1 homolog 1; Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling."},{"id":"ENSMUSP00000018905","abundance":18.8,"rank":2945,"name":"Mpdu1","annotation":"Mannose-P-dolichol utilization defect 1 protein; Required for normal utilization of mannose-dolichol phosphate (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides and GPI anchors; Belongs to the MPDU1 (TC 2.A.43.3) family."},{"id":"ENSMUSP00000024206","abundance":18.8,"rank":2946,"name":"Gnb3","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000035415","abundance":18.7,"rank":2947,"name":"Atxn2l","annotation":"Ataxin-2-like protein; Involved in the regulation of stress granule and P-body formation."},{"id":"ENSMUSP00000133931","abundance":18.7,"rank":2948,"name":"Prps1l1","annotation":"Phosphoribosyl pyrophosphate synthetase 1-like 1."},{"id":"ENSMUSP00000077074","abundance":18.7,"rank":2949,"name":"Cfi","annotation":"Complement factor I heavy chain; Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha- chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired [...] "},{"id":"ENSMUSP00000025602","abundance":18.7,"rank":2950,"name":"Gna14","annotation":"Guanine nucleotide-binding protein subunit alpha-14; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily."},{"id":"ENSMUSP00000016105","abundance":18.7,"rank":2951,"name":"Adss","annotation":"Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family."},{"id":"ENSMUSP00000026890","abundance":18.7,"rank":2952,"name":"Clec3b","annotation":"Tetranectin; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis (By similarity)."},{"id":"ENSMUSP00000085763","abundance":18.6,"rank":2953,"name":"Mbnl2","annotation":"Muscleblind-like protein 2; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expr [...] "},{"id":"ENSMUSP00000109671","abundance":18.6,"rank":2954,"name":"Son","annotation":"Protein SON; RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' (By similarity). Essential for correct RNA splicing of mu [...] "},{"id":"ENSMUSP00000153488","abundance":18.6,"rank":2955,"name":"Mat1a","annotation":"S-adenosylmethionine synthase isoform type-1; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate; Belongs to the AdoMet synthase family."},{"id":"ENSMUSP00000143838","abundance":18.6,"rank":2956,"name":"Sds","annotation":"L-serine dehydratase/L-threonine deaminase; Belongs to the serine/threonine dehydratase family."},{"id":"ENSMUSP00000117677","abundance":18.6,"rank":2957,"name":"Gm20547","annotation":"Predicted gene 20547; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000110860","abundance":18.5,"rank":2958,"name":"Nrf1","annotation":"Nuclear respiratory factor 1; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity)."},{"id":"ENSMUSP00000040244","abundance":18.5,"rank":2959,"name":"Akr1b8","annotation":"Aldose reductase-related protein 2."},{"id":"ENSMUSP00000094667","abundance":18.5,"rank":2960,"name":"Reg3b","annotation":"Regenerating islet-derived protein 3-beta 16.5 kDa form; Bactericidal C-type lectin which acts against several intestinal Gram-positive and Gram-negative bacteria. Lacks antibacterial activity against S.typhimurium. May play a role in protection against infection with S.enteritidis by inhibiting its translocation from the gut lumen into intestinal tissues and further extraintestinal tissues."},{"id":"ENSMUSP00000029666","abundance":18.5,"rank":2961,"name":"Papss1","annotation":"Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Required  [...] "},{"id":"ENSMUSP00000094528","abundance":18.5,"rank":2962,"name":"Eml4","annotation":"Echinoderm microtubule-associated protein-like 4; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic."},{"id":"ENSMUSP00000008748","abundance":18.5,"rank":2963,"name":"Ubqln4","annotation":"Ubiquilin-4; Regulator of protein degradation that mediates the proteasomal targeting of misfolded, mislocalized or accumulated proteins (By similarity). Acts by binding polyubiquitin chains of target proteins via its UBA domain and by interacting with subunits of the proteasome via its ubiquitin-like domain (By similarity). Key regulator of DNA repair that represses homologous recombination repair: in response to DNA damage, recruited to sites of DNA damage following phosphorylation by ATM and acts by binding and removing ubiquitinated MRE11 from damaged chromatin, leading to MRE11 de [...] "},{"id":"ENSMUSP00000106957","abundance":18.5,"rank":2964,"name":"Sdr39u1","annotation":"Epimerase family protein SDR39U1; Putative NADP-dependent oxidoreductase."},{"id":"ENSMUSP00000105926","abundance":18.5,"rank":2965,"name":"Oxr1","annotation":"Oxidation resistance protein 1; May be involved in protection from oxidative damage; Belongs to the OXR1 family."},{"id":"ENSMUSP00000113716","abundance":18.5,"rank":2966,"name":"Dctn6","annotation":"Dynactin subunit 6; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily."},{"id":"ENSMUSP00000117509","abundance":18.4,"rank":2967,"name":"Gpd1l","annotation":"Glycerol-3-phosphate dehydrogenase 1-like protein; Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3- phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L."},{"id":"ENSMUSP00000030914","abundance":18.4,"rank":2968,"name":"Rer1","annotation":"Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment; Belongs to the RER1 family."},{"id":"ENSMUSP00000075655","abundance":18.4,"rank":2969,"name":"Prpf40a","annotation":"Pre-mRNA-processing factor 40 homolog A; Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing; Belongs to the PRPF40 family."},{"id":"ENSMUSP00000022197","abundance":18.4,"rank":2970,"name":"Scamp1","annotation":"Secretory carrier-associated membrane protein 1; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity)."},{"id":"ENSMUSP00000113308","abundance":18.4,"rank":2971,"name":"Synj1","annotation":"Synaptojanin-1; Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (By similarity). Has a role in clathrin-mediated endocytosis (By similarity). Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). Belongs to the synaptojanin family."},{"id":"ENSMUSP00000001920","abundance":18.4,"rank":2972,"name":"Aif1l","annotation":"Allograft inflammatory factor 1-like; Actin-binding protein that promotes actin bundling. May neither bind calcium nor depend on calcium for function (By similarity)."},{"id":"ENSMUSP00000110974","abundance":18.3,"rank":2973,"name":"Klhl13","annotation":"Kelch-like protein 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity)."},{"id":"ENSMUSP00000110411","abundance":18.3,"rank":2974,"name":"Fstl1","annotation":"Follistatin-related protein 1; May modulate the action of some growth factors on cell proliferation and differentiation. Binds heparin (By similarity)."},{"id":"ENSMUSP00000145765","abundance":18.3,"rank":2975,"name":"Gm45213","annotation":"Predicted gene 45213."},{"id":"ENSMUSP00000055827","abundance":18.3,"rank":2976,"name":"Fahd1","annotation":"Acylpyruvase FAHD1, mitochondrial; Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro (By similarity). Also has oxaloacetate decarboxylase activity. Belongs to the FAH family."},{"id":"ENSMUSP00000000153","abundance":18.3,"rank":2977,"name":"Gna12","annotation":"Guanine nucleotide-binding protein subunit alpha-12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activatin [...] "},{"id":"ENSMUSP00000045362","abundance":18.3,"rank":2978,"name":"Cyp2c37","annotation":"Cytochrome P450 2C37; Metabolizes arachidonic acid to produce 12- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000060940","abundance":18.3,"rank":2979,"name":"Rtn4ip1","annotation":"Reticulon-4-interacting protein 1, mitochondrial; Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily."},{"id":"ENSMUSP00000025474","abundance":18.3,"rank":2980,"name":"Napg","annotation":"Gamma-soluble NSF attachment protein; Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus."},{"id":"ENSMUSP00000022504","abundance":18.2,"rank":2981,"name":"Mapk8","annotation":"Mitogen-activated protein kinase."},{"id":"ENSMUSP00000025910","abundance":18.2,"rank":2982,"name":"Bad","annotation":"Bcl2-associated agonist of cell death; Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways."},{"id":"ENSMUSP00000121637","abundance":18.2,"rank":2983,"name":"Smim20","annotation":"Small integral membrane protein 20; [Small integral membrane protein 20]: Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly (By similarity). Promotes the progression of complex assembly after the association of MT-CO1/COX1 with COX4I1 and COX6C (By similarity). Chaperone-like assembly factor required to stabilize newly synthesized MT-CO1/COX1 and to prevent its premature turnover (By similarity). [Phoenixin-20]: Peptide involved in a broad spectrum of regulatory func [...] "},{"id":"ENSMUSP00000112304","abundance":18.2,"rank":2984,"name":"Mad2l1","annotation":"Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate (By similarity); Belongs to the MAD2 family."},{"id":"ENSMUSP00000030935","abundance":18.2,"rank":2985,"name":"Prxl2b","annotation":"Prostamide/prostaglandin F synthase; Catalyzes the reduction of prostaglandin-ethanolamide H(2) (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor. Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha)."},{"id":"ENSMUSP00000082406","abundance":18.2,"rank":2986,"name":"Daam1","annotation":"Disheveled-associated activator of morphogenesis 1; Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly. Belongs to the formin homology family."},{"id":"ENSMUSP00000037555","abundance":18.2,"rank":2987,"name":"Ces1g","annotation":"Liver carboxylesterase 1; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000110126","abundance":18.1,"rank":2988,"name":"Il1rn","annotation":"Interleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity; Belongs to the IL-1 family."},{"id":"ENSMUSP00000065754","abundance":18.1,"rank":2989,"name":"Msra","annotation":"Mitochondrial peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)."},{"id":"ENSMUSP00000030091","abundance":18.1,"rank":2990,"name":"Pole3","annotation":"DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 (By similarity)."},{"id":"ENSMUSP00000066915","abundance":18.1,"rank":2991,"name":"Amacr","annotation":"Alpha-methylacyl-CoA racemase; Catalyzes the interconversion of (R)- and (S)-stereoisomers of alpha-methyl-branched-chain fatty acyl-CoA esters (By similarity). Acts only on coenzyme A thioesters, not on free fatty acids, and accepts as substrates a wide range of alpha-methylacyl-CoAs, including pristanoyl-CoA, trihydroxycoprostanoyl-CoA (an intermediate in bile acid synthesis), and arylpropionic acids like the anti-inflammatory drug ibuprofen (2-(4-isobutylphenyl)propionic acid) but neither 3- methyl-branched nor linear-chain acyl-CoAs (By similarity). Belongs to the CoA-transferase I [...] "},{"id":"ENSMUSP00000099723","abundance":18.1,"rank":2992,"name":"P3h1","annotation":"Prolyl 3-hydroxylase 1; Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post- translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts (By similarity)."},{"id":"ENSMUSP00000059494","abundance":18.1,"rank":2993,"name":"Tmem11","annotation":"Transmembrane protein 11, mitochondrial; Plays a role in mitochondrial morphogenesis."},{"id":"ENSMUSP00000025617","abundance":18.1,"rank":2994,"name":"Rfk","annotation":"Riboflavin kinase; Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF- activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase (By similarity)."},{"id":"ENSMUSP00000118759","abundance":18,"rank":2995,"name":"Terf2","annotation":"Telomeric repeat-binding factor 2; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA- binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'- TTAGGG-3' repeats added [...] "},{"id":"ENSMUSP00000105173","abundance":18,"rank":2996,"name":"Vcan","annotation":"Versican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid."},{"id":"ENSMUSP00000002121","abundance":18,"rank":2997,"name":"Supt6","annotation":"Transcription elongation factor SPT6; Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C- terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex  [...] "},{"id":"ENSMUSP00000030029","abundance":18,"rank":2998,"name":"Invs","annotation":"Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin- proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be st [...] "},{"id":"ENSMUSP00000045351","abundance":18,"rank":2999,"name":"Pigk","annotation":"GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein (By similarity)."},{"id":"ENSMUSP00000140835","abundance":18,"rank":3000,"name":"Tbrg4","annotation":"FAST kinase domain-containing protein 4; Plays a role in processing of mitochondrial RNA precursors and in stabilization of a subset of mature mitochondrial RNA species, such as MT-CO1, MT-CO2, MT-CYB, MT-CO3, MT-ND3, MT-ND5 and MT-ATP8/6. May play a role in cell cycle progression. Belongs to the FAST kinase family."},{"id":"ENSMUSP00000003117","abundance":18,"rank":3001,"name":"Ap1m1","annotation":"AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules."},{"id":"ENSMUSP00000040005","abundance":18,"rank":3002,"name":"Rbm42","annotation":"RNA-binding protein 42; Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA."},{"id":"ENSMUSP00000134854","abundance":18,"rank":3003,"name":"Stx5a","annotation":"Syntaxin-5; Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter- connected structure of the Golgi apparatus."},{"id":"ENSMUSP00000019615","abundance":18,"rank":3004,"name":"Cdc37","annotation":"Hsp90 co-chaperone Cdc37, N-terminally processed; Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity. Inhibits HSP90AA1 ATPase activity (By similarity); Belongs to the CDC37 family."},{"id":"ENSMUSP00000044645","abundance":18,"rank":3005,"name":"Smc1a","annotation":"Structural maintenance of chromosomes protein 1A; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, and works as a downstream effector in the ATM/NBS1 branch of S-phase checkpoint (By similarity). Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and  [...] "},{"id":"ENSMUSP00000022378","abundance":17.9,"rank":3006,"name":"Ero1l","annotation":"ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (By similarity). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-tri [...] "},{"id":"ENSMUSP00000031167","abundance":17.9,"rank":3007,"name":"Polr2b","annotation":"DNA-directed RNA polymerase II subunit RPB2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is  [...] "},{"id":"ENSMUSP00000083652","abundance":17.9,"rank":3008,"name":"Rfc5","annotation":"Replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1."},{"id":"ENSMUSP00000026013","abundance":17.9,"rank":3009,"name":"Maoa","annotation":"Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity)."},{"id":"ENSMUSP00000027498","abundance":17.9,"rank":3010,"name":"Stk25","annotation":"Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (By similarity)."},{"id":"ENSMUSP00000145160","abundance":17.9,"rank":3011,"name":"Add2","annotation":"Beta-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit (By similarity)."},{"id":"ENSMUSP00000076816","abundance":17.9,"rank":3012,"name":"Pigu","annotation":"Phosphatidylinositol glycan anchor biosynthesis class U protein; Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI (By similarity); Belongs to the PIGU family."},{"id":"ENSMUSP00000054168","abundance":17.9,"rank":3013,"name":"Zfp207","annotation":"BUB3-interacting and GLEBS motif-containing protein ZNF207; Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetoc [...] "},{"id":"ENSMUSP00000035489","abundance":17.8,"rank":3014,"name":"Fmod","annotation":"Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis."},{"id":"ENSMUSP00000015146","abundance":17.8,"rank":3015,"name":"Efr3a","annotation":"Protein EFR3 homolog A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect."},{"id":"ENSMUSP00000008893","abundance":17.8,"rank":3016,"name":"Coro1b","annotation":"Coronin-1B; Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity)."},{"id":"ENSMUSP00000096293","abundance":17.8,"rank":3017,"name":"Psd3","annotation":"PH and SEC7 domain-containing protein 3; Guanine nucleotide exchange factor for ARF6."},{"id":"ENSMUSP00000087525","abundance":17.8,"rank":3018,"name":"Pla2g4e","annotation":"Cytosolic phospholipase A2 epsilon; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position."},{"id":"ENSMUSP00000133076","abundance":17.7,"rank":3019,"name":"Tnpo2","annotation":"Transportin-2; Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hy [...] "},{"id":"ENSMUSP00000029815","abundance":17.7,"rank":3020,"name":"Cisd2","annotation":"CDGSH iron-sulfur domain-containing protein 2; Regulator of autophagy that contributes to antagonize BECN1- mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy (By similarity). Belongs to the CISD protein family. CISD2 subfamily."},{"id":"ENSMUSP00000033805","abundance":17.7,"rank":3021,"name":"Psmd10","annotation":"26S proteasome non-ATPase regulatory subunit 10; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module (By similarity). Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis."},{"id":"ENSMUSP00000101940","abundance":17.7,"rank":3022,"name":"Sez6l2","annotation":"Seizure 6-like protein 2; May contribute to specialized endoplasmic reticulum functions in neurons."},{"id":"ENSMUSP00000059983","abundance":17.7,"rank":3023,"name":"Nudt1","annotation":"7,8-dihydro-8-oxoguanine triphosphatase; Antimutagenic. Plays a redundant role in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP (By similarity). D [...] "},{"id":"ENSMUSP00000030942","abundance":17.7,"rank":3024,"name":"Mrpl20","annotation":"39S ribosomal protein L20, mitochondrial; Belongs to the bacterial ribosomal protein bL20 family."},{"id":"ENSMUSP00000007449","abundance":17.7,"rank":3025,"name":"Akr1b7","annotation":"Aldo-keto reductase family 1 member B7; Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. Reduces prostaglandins. May play a role in the metabolism of xenobiotic aromatic aldehydes (By similarity); Belongs to the aldo/keto reductase family."},{"id":"ENSMUSP00000020629","abundance":17.7,"rank":3026,"name":"Gfpt2","annotation":"Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2; Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins."},{"id":"ENSMUSP00000110175","abundance":17.7,"rank":3027,"name":"Acbd5","annotation":"Acyl-CoA-binding domain-containing protein 5; Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters (By similarity)."},{"id":"ENSMUSP00000047778","abundance":17.6,"rank":3028,"name":"Nudt19","annotation":"Nucleoside diphosphate-linked moiety X motif 19; Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty- acyl-CoA esters. At low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates."},{"id":"ENSMUSP00000021550","abundance":17.6,"rank":3029,"name":"Arg2","annotation":"Arginase-2, mitochondrial; May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May contribute to the immune evasion of H.pylori by restricting  [...] "},{"id":"ENSMUSP00000017365","abundance":17.6,"rank":3030,"name":"Psmd3","annotation":"26S proteasome non-ATPase regulatory subunit 3; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S3 family."},{"id":"ENSMUSP00000042232","abundance":17.6,"rank":3031,"name":"Hebp1","annotation":"Heme-binding protein 1; May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N-methylprotoporphyrin with similar affinities."},{"id":"ENSMUSP00000032735","abundance":17.6,"rank":3032,"name":"Mphosph10","annotation":"U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity); Belongs to the MPP10 family."},{"id":"ENSMUSP00000020820","abundance":17.6,"rank":3033,"name":"Mrpl22","annotation":"39S ribosomal protein L22, mitochondrial; Belongs to the universal ribosomal protein uL22 family."},{"id":"ENSMUSP00000026144","abundance":17.6,"rank":3034,"name":"Dcxr","annotation":"L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules."},{"id":"ENSMUSP00000034428","abundance":17.6,"rank":3035,"name":"Gabarapl2","annotation":"Gamma-aminobutyric acid receptor-associated protein-like 2; Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved [...] "},{"id":"ENSMUSP00000025631","abundance":17.6,"rank":3036,"name":"Ostf1","annotation":"Osteoclast-stimulating factor 1; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity."},{"id":"ENSMUSP00000018466","abundance":17.6,"rank":3037,"name":"Tomm34","annotation":"Mitochondrial import receptor subunit TOM34; Plays a role in the import of cytosolically synthesized preproteins into mitochondria. Binds the mature portion of precursor proteins. Interacts with cellular components, and possesses weak ATPase activity. May be a chaperone-like protein that helps to keep newly synthesized precursors in an unfolded import compatible state (By similarity)."},{"id":"ENSMUSP00000095845","abundance":17.6,"rank":3038,"name":"Ttpa","annotation":"Alpha-tocopherol transfer protein; Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5- bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol."},{"id":"ENSMUSP00000002837","abundance":17.6,"rank":3039,"name":"Tmed5","annotation":"Transmembrane emp24 domain-containing protein 5; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport (By similarity)."},{"id":"ENSMUSP00000054307","abundance":17.6,"rank":3040,"name":"Cxxc5","annotation":"CXXC-type zinc finger protein 5; May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity).  [...] "},{"id":"ENSMUSP00000107830","abundance":17.6,"rank":3041,"name":"Prkcd","annotation":"Protein kinase C delta type regulatory subunit; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation a [...] "},{"id":"ENSMUSP00000017637","abundance":17.6,"rank":3042,"name":"Igfbp4","annotation":"Insulin-like growth factor-binding protein 4; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors."},{"id":"ENSMUSP00000115738","abundance":17.5,"rank":3043,"name":"Ube2e2","annotation":"Ubiquitin-conjugating enzyme E2 E2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein. Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000023095","abundance":17.5,"rank":3044,"name":"Sept3","annotation":"Neuronal-specific septin-3; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)."},{"id":"ENSMUSP00000141132","abundance":17.5,"rank":3045,"name":"Stat1","annotation":"Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to  [...] "},{"id":"ENSMUSP00000065613","abundance":17.5,"rank":3046,"name":"Fam49a","annotation":"Protein FAM49A; Belongs to the FAM49 family."},{"id":"ENSMUSP00000005620","abundance":17.5,"rank":3047,"name":"Dnajb1","annotation":"DnaJ homolog subfamily B member 1; Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)."},{"id":"ENSMUSP00000005685","abundance":17.5,"rank":3048,"name":"Cyp2a5","annotation":"Cytochrome P450 2A5; Exhibits a high coumarin 7-hydroxylase activity."},{"id":"ENSMUSP00000051293","abundance":17.5,"rank":3049,"name":"Clptm1","annotation":"Cleft lip and palate transmembrane protein 1 homolog; May play a role in T-cell development."},{"id":"ENSMUSP00000040975","abundance":17.5,"rank":3050,"name":"4921524J17Rik","annotation":"UPF0547 protein C16orf87 homolog; Belongs to the UPF0547 family."},{"id":"ENSMUSP00000050446","abundance":17.5,"rank":3051,"name":"Irgm1","annotation":"Immunity-related GTPase family M protein 1; Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion. Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family."},{"id":"ENSMUSP00000031731","abundance":17.5,"rank":3052,"name":"Pcolce","annotation":"Procollagen C-endopeptidase enhancer 1; Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity."},{"id":"ENSMUSP00000058811","abundance":17.4,"rank":3053,"name":"Gm9833","annotation":"Myelin expression factor 2."},{"id":"ENSMUSP00000025186","abundance":17.4,"rank":3054,"name":"Slc39a7","annotation":"Zinc transporter SLC39A7; Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol. Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily."},{"id":"ENSMUSP00000029402","abundance":17.4,"rank":3055,"name":"Slc33a1","annotation":"Acetyl-coenzyme A transporter 1; Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling (By similarity); Belongs to the SLC33A transporter family."},{"id":"ENSMUSP00000006764","abundance":17.4,"rank":3056,"name":"Aprt","annotation":"Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis."},{"id":"ENSMUSP00000025357","abundance":17.4,"rank":3057,"name":"Ap3s1","annotation":"AP-3 complex subunit sigma-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals."},{"id":"ENSMUSP00000131355","abundance":17.4,"rank":3058,"name":"Glg1","annotation":"Golgi apparatus protein 1; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils)."},{"id":"ENSMUSP00000113556","abundance":17.4,"rank":3059,"name":"Itga3","annotation":"Integrin alpha-3 heavy chain; Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha- 3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration."},{"id":"ENSMUSP00000038555","abundance":17.4,"rank":3060,"name":"Pck2","annotation":"Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle."},{"id":"ENSMUSP00000097968","abundance":17.4,"rank":3061,"name":"Xrcc6","annotation":"X-ray repair cross-complementing protein 6; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] "},{"id":"ENSMUSP00000114968","abundance":17.4,"rank":3062,"name":"Plrg1","annotation":"Pleiotropic regulator 1; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing."},{"id":"ENSMUSP00000026434","abundance":17.4,"rank":3063,"name":"Chmp6","annotation":"Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function [...] "},{"id":"ENSMUSP00000040246","abundance":17.4,"rank":3064,"name":"C1qb","annotation":"Complement C1q subcomponent subunit B; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes."},{"id":"ENSMUSP00000033776","abundance":17.4,"rank":3065,"name":"Dkc1","annotation":"H/ACA ribonucleoprotein complex subunit DKC1; Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance (By similarity). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the te [...] "},{"id":"ENSMUSP00000157722","abundance":17.4,"rank":3066,"name":"Gpam","annotation":"Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Belongs to the GPAT/DAPAT family."},{"id":"ENSMUSP00000021692","abundance":17.4,"rank":3067,"name":"Yy1","annotation":"Transcriptional repressor protein YY1; Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activa [...] "},{"id":"ENSMUSP00000084617","abundance":17.4,"rank":3068,"name":"Cryge","annotation":"Gamma-crystallin E; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000045327","abundance":17.4,"rank":3069,"name":"Crygd","annotation":"Gamma-crystallin D; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family."},{"id":"ENSMUSP00000108350","abundance":17.3,"rank":3070,"name":"Serpinb5","annotation":"Serpin B5; Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity)."},{"id":"ENSMUSP00000046358","abundance":17.3,"rank":3071,"name":"Dagla","annotation":"Sn1-specific diacylglycerol lipase alpha; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity). Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000131199","abundance":17.3,"rank":3072,"name":"Pycr1","annotation":"Pyrroline-5-carboxylate reductase 1, mitochondrial; Housekeeping enzyme that catalyzes the last step in proline biosynthesis. Can utilize both NAD and NADP, but has higher affinity for NAD. Involved in the cellular response to oxidative stress."},{"id":"ENSMUSP00000003947","abundance":17.3,"rank":3073,"name":"Nqo1","annotation":"NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis."},{"id":"ENSMUSP00000028087","abundance":17.3,"rank":3074,"name":"Ppp6c","annotation":"Serine/threonine-protein phosphatase 6 catalytic subunit; Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential  [...] "},{"id":"ENSMUSP00000003642","abundance":17.3,"rank":3075,"name":"Klc4","annotation":"Kinesin light chain 4; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity (By similarity)."},{"id":"ENSMUSP00000030985","abundance":17.3,"rank":3076,"name":"Hgfac","annotation":"Hepatocyte growth factor activator short chain; Activates hepatocyte growth factor (HGF) by converting it from a single chain to a heterodimeric form."},{"id":"ENSMUSP00000037259","abundance":17.3,"rank":3077,"name":"Fmo1","annotation":"Dimethylaniline monooxygenase [N-oxide-forming] 1; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Form I catalyzes the N-oxygenation of secondary and tertiary amines."},{"id":"ENSMUSP00000103350","abundance":17.2,"rank":3078,"name":"Spop","annotation":"Speckle-type POZ protein; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL (By similarity). In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3 [...] "},{"id":"ENSMUSP00000142737","abundance":17.2,"rank":3079,"name":"Pdlim5","annotation":"PDZ and LIM domain protein 5."},{"id":"ENSMUSP00000106018","abundance":17.2,"rank":3080,"name":"Gphn","annotation":"Molybdopterin molybdenumtransferase; Microtubule-associated protein involved in membrane protein- cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. In the C-terminal section; belongs to the MoeA family."},{"id":"ENSMUSP00000009727","abundance":17.2,"rank":3081,"name":"Syngr1","annotation":"Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity. Belongs to the synaptogyrin family."},{"id":"ENSMUSP00000025503","abundance":17.2,"rank":3082,"name":"Isoc1","annotation":"Isochorismatase domain-containing protein 1; Belongs to the isochorismatase family."},{"id":"ENSMUSP00000020705","abundance":17.2,"rank":3083,"name":"Pes1","annotation":"Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family."},{"id":"ENSMUSP00000034388","abundance":17.2,"rank":3084,"name":"Vps4a","annotation":"Vacuolar protein sorting-associated protein 4A; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] "},{"id":"ENSMUSP00000020277","abundance":17.2,"rank":3085,"name":"Hkdc1","annotation":"Hexokinase HKDC1; Catalyzes the phosphorylation of hexose to hexose 6- phosphate, although at very low level compared to other hexokinases (By similarity). Has low glucose phosphorylating activity compared to other hexokinases (By similarity). Involved in glucose homeostasis and hepatic lipid accumulation. Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidences are required to confirm this role."},{"id":"ENSMUSP00000032192","abundance":17.2,"rank":3086,"name":"Itpr1","annotation":"Inositol 1,4,5-trisphosphate receptor type 1; Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways."},{"id":"ENSMUSP00000005509","abundance":17.2,"rank":3087,"name":"Stx1a","annotation":"Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] "},{"id":"ENSMUSP00000127566","abundance":17.1,"rank":3088,"name":"Guk1","annotation":"Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP). Involved in the cGMP metabolism in photoreceptors (By similarity). Belongs to the guanylate kinase family."},{"id":"ENSMUSP00000119565","abundance":17.1,"rank":3089,"name":"Czib","annotation":"CXXC motif containing zinc binding protein."},{"id":"ENSMUSP00000021536","abundance":17.1,"rank":3090,"name":"Atp6v1d","annotation":"V-type proton ATPase subunit D; Subunit of the peripheral V1 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity)."},{"id":"ENSMUSP00000062771","abundance":17.1,"rank":3091,"name":"Rasef","annotation":"Ras and EF-hand domain-containing protein homolog; Binds predominantly GDP, and also GTP; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000068896","abundance":17.1,"rank":3092,"name":"Top2a","annotation":"DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation."},{"id":"ENSMUSP00000026551","abundance":17.1,"rank":3093,"name":"Dpysl4","annotation":"Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family."},{"id":"ENSMUSP00000043519","abundance":17.1,"rank":3094,"name":"Exosc2","annotation":"Exosome complex component RRP4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytop [...] "},{"id":"ENSMUSP00000141070","abundance":17.1,"rank":3095,"name":"Sh2d1a","annotation":"SH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (By similarity). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) ce [...] "},{"id":"ENSMUSP00000130811","abundance":17.1,"rank":3096,"name":"Lamtor3","annotation":"Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] "},{"id":"ENSMUSP00000027193","abundance":17.1,"rank":3097,"name":"Ndufb3","annotation":"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone."},{"id":"ENSMUSP00000024981","abundance":17,"rank":3098,"name":"Jpt2","annotation":"Jupiter microtubule associated homolog 2."},{"id":"ENSMUSP00000048460","abundance":17,"rank":3099,"name":"Fxyd1","annotation":"Phospholemman; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (By similarity). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation- mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone."},{"id":"ENSMUSP00000150903","abundance":17,"rank":3100,"name":"Acp5","annotation":"Tartrate-resistant acid phosphatase type 5; May play a role in the process of bone resorption. The osteoclastic trap acts on nucleotide tri- and diphosphates with higher affinity, compared with other substrates."},{"id":"ENSMUSP00000047543","abundance":17,"rank":3101,"name":"Ctdspl2","annotation":"CTD small phosphatase-like protein 2; Probable phosphatase; Belongs to the CTDSPL2 family."},{"id":"ENSMUSP00000039406","abundance":17,"rank":3102,"name":"U2af1l4","annotation":"Splicing factor U2AF 26 kDa subunit; RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. It can functionally substitute for U2AF1 in constitutive splicing and enhancer-dependent splicing. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; [...] "},{"id":"ENSMUSP00000102255","abundance":17,"rank":3103,"name":"Nrd1","annotation":"Nardilysin; Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs."},{"id":"ENSMUSP00000087327","abundance":17,"rank":3104,"name":"Masp1","annotation":"Mannan-binding lectin serine protease 1 heavy chain; Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of  [...] "},{"id":"ENSMUSP00000087773","abundance":17,"rank":3105,"name":"Erc2","annotation":"ERC protein 2; Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ."},{"id":"ENSMUSP00000098414","abundance":17,"rank":3106,"name":"Pbp2","annotation":"Phosphatidylethanolamine-binding protein 2; May bind to phospholipids. May act as serine protease inhibitor (By similarity)."},{"id":"ENSMUSP00000096775","abundance":17,"rank":3107,"name":"Kif5a","annotation":"Kinesin heavy chain isoform 5A; Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. [...] "},{"id":"ENSMUSP00000055528","abundance":17,"rank":3108,"name":"Tmem88","annotation":"Transmembrane protein 88; Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre- cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity); Belongs to the TMEM88 family."},{"id":"ENSMUSP00000006611","abundance":17,"rank":3109,"name":"Srm","annotation":"Spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3- diaminopropane. Has extremely low activity towards spermidine (By similarity)."},{"id":"ENSMUSP00000113807","abundance":16.9,"rank":3110,"name":"Aip","annotation":"AH receptor-interacting protein; May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting."},{"id":"ENSMUSP00000027356","abundance":16.9,"rank":3111,"name":"Cyp27a1","annotation":"Sterol 26-hydroxylase, mitochondrial; Cytochrome P450 monooxygenase that catalyzes regio- and stereospecific hydroxylation of cholesterol and its derivatives. Hydroxylates (with R stereochemistry) the terminal methyl group of cholesterol side-chain in a three step reaction to yield at first a C26 alcohol, then a C26 aldehyde and finally a C26 acid. Regulates cholesterol homeostasis by catalyzing the conversion of excess cholesterol to bile acids via both the 'neutral' (classic) and the 'acid' (alternative) pathways. May also regulate cholesterol homeostasis via generation of active oxy [...] "},{"id":"ENSMUSP00000126036","abundance":16.9,"rank":3112,"name":"Sumf2","annotation":"Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family."},{"id":"ENSMUSP00000043561","abundance":16.9,"rank":3113,"name":"Mrpl41","annotation":"39S ribosomal protein L41, mitochondrial; Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins."},{"id":"ENSMUSP00000077564","abundance":16.9,"rank":3114,"name":"BC048507","annotation":"Dynein light chain."},{"id":"ENSMUSP00000002855","abundance":16.9,"rank":3115,"name":"Kdelr1","annotation":"ER lumen protein-retaining receptor 1; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum. Belongs to the ERD2 family."},{"id":"ENSMUSP00000028177","abundance":16.9,"rank":3116,"name":"Olfm1","annotation":"Noelin; Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse. May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli."},{"id":"ENSMUSP00000035034","abundance":16.9,"rank":3117,"name":"Mrps22","annotation":"28S ribosomal protein S22, mitochondrial."},{"id":"ENSMUSP00000125871","abundance":16.9,"rank":3118,"name":"Six2","annotation":"Homeobox protein SIX2; Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Al [...] "},{"id":"ENSMUSP00000038368","abundance":16.8,"rank":3119,"name":"Copg2","annotation":"Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] "},{"id":"ENSMUSP00000106894","abundance":16.8,"rank":3120,"name":"Vangl2","annotation":"Vang-like protein 2; Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear."},{"id":"ENSMUSP00000041022","abundance":16.8,"rank":3121,"name":"Lsm1","annotation":"U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (By similarity). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). Belongs to the snRNP Sm proteins family."},{"id":"ENSMUSP00000056715","abundance":16.7,"rank":3122,"name":"Atxn2","annotation":"Ataxin-2; Involved in EGFR trafficking, acting as negative regulator of endocytic EGFR internalization at the plasma membrane. Belongs to the ataxin-2 family."},{"id":"ENSMUSP00000001565","abundance":16.7,"rank":3123,"name":"Gtf2h4","annotation":"General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] "},{"id":"ENSMUSP00000124417","abundance":16.7,"rank":3124,"name":"C6","annotation":"Complement component 6."},{"id":"ENSMUSP00000049258","abundance":16.7,"rank":3125,"name":"Ambra1","annotation":"Activating molecule in BECN1-regulated autophagy protein 1; Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation."},{"id":"ENSMUSP00000114928","abundance":16.7,"rank":3126,"name":"Dynlrb1","annotation":"Dynein light chain roadblock-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules."},{"id":"ENSMUSP00000035163","abundance":16.7,"rank":3127,"name":"1300017J02Rik","annotation":"Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions."},{"id":"ENSMUSP00000035033","abundance":16.7,"rank":3128,"name":"Copb2","annotation":"Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also infl [...] "},{"id":"ENSMUSP00000002733","abundance":16.7,"rank":3129,"name":"Gtf2f1","annotation":"General transcription factor IIF subunit 1; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation (By similarity); Belongs to the TFIIF alpha subunit family."},{"id":"ENSMUSP00000021046","abundance":16.7,"rank":3130,"name":"Ddx42","annotation":"ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby c [...] "},{"id":"ENSMUSP00000066413","abundance":16.6,"rank":3131,"name":"Setd3","annotation":"Actin-histidine N-methyltransferase; Protein-histidine N-methyltransferase that specifically mediates methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin. Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family."},{"id":"ENSMUSP00000099138","abundance":16.6,"rank":3132,"name":"Smarca1","annotation":"Probable global transcription activator SNF2L1; Energy-transducing component of the NURF (nucleosome- remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes, which facilitate the perturbation of chromatin structure in an ATP-dependent manner."},{"id":"ENSMUSP00000020672","abundance":16.6,"rank":3133,"name":"Fabp6","annotation":"Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes. Stimulates gastric acid and pepsinogen secretion (By similarity). Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family."},{"id":"ENSMUSP00000099765","abundance":16.6,"rank":3134,"name":"Rad54l","annotation":"DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). Deficient mice also show significantly shorter telomeres than wild-type controls, indicating that the protein activity plays an essential role in telomere length maintenance in mammals. Deficiency also resulted in an increased frequency of end-to-end chromosome fusions involving telo [...] "},{"id":"ENSMUSP00000084572","abundance":16.6,"rank":3135,"name":"Vars","annotation":"Valine--tRNA ligase."},{"id":"ENSMUSP00000051965","abundance":16.6,"rank":3136,"name":"Exoc4","annotation":"Exocyst complex component 4; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane; Belongs to the SEC8 family."},{"id":"ENSMUSP00000003659","abundance":16.6,"rank":3137,"name":"Comp","annotation":"Cartilage oligomeric matrix protein; May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BI [...] "},{"id":"ENSMUSP00000030771","abundance":16.6,"rank":3138,"name":"Dnajc2","annotation":"DnaJ homolog subfamily C member 2; Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histo [...] "},{"id":"ENSMUSP00000042150","abundance":16.6,"rank":3139,"name":"Rras","annotation":"Ras-related protein R-Ras; Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity. Belongs to the small GTPase superfamily. Ras family."},{"id":"ENSMUSP00000021148","abundance":16.5,"rank":3140,"name":"Ube2g1","annotation":"Ubiquitin-conjugating enzyme E2 G1, N-terminally processed; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4; Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000033920","abundance":16.5,"rank":3141,"name":"Aga","annotation":"N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins. Belongs to the Ntn-hydrolase family."},{"id":"ENSMUSP00000051487","abundance":16.5,"rank":3142,"name":"Hpcal4","annotation":"Hippocalcin-like protein 4; May be involved in the calcium-dependent regulation of rhodopsin phosphorylation; Belongs to the recoverin family."},{"id":"ENSMUSP00000108391","abundance":16.4,"rank":3143,"name":"Dspp","annotation":"Dentin sialophosphoprotein; DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals."},{"id":"ENSMUSP00000088456","abundance":16.4,"rank":3144,"name":"Dap3","annotation":"28S ribosomal protein S29, mitochondrial; Involved in mediating interferon-gamma-induced cell death. Belongs to the mitochondrion-specific ribosomal protein mS29 family."},{"id":"ENSMUSP00000020372","abundance":16.4,"rank":3145,"name":"Uqcr11","annotation":"Cytochrome b-c1 complex subunit 10; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the in [...] "},{"id":"ENSMUSP00000024773","abundance":16.4,"rank":3146,"name":"Prph2","annotation":"Peripherin-2; Essential for retina photoreceptor outer segment disk morphogenesis, may also play a role with ROM1 in the maintenance of outer segment disk structure. Required for the maintenance of retinal outer nuclear layer thickness. Required for the correct development and organization of the photoreceptor inner segment. Belongs to the PRPH2/ROM1 family."},{"id":"ENSMUSP00000034178","abundance":16.4,"rank":3147,"name":"Ces1f","annotation":"Carboxylesterase 1F; Hydrolyzes p-nitrophenyl butyrate (PNPB), triacylglycerol and monoacylglycerol. Shows higher activity against PNPB, a short-chain fatty acid ester, than against triolein, a long-chain fatty acid ester. Shows no detectable activity against diacylglycerol, cholesterol ester or phospholipids. May play a role in adipocyte lipolysis."},{"id":"ENSMUSP00000021282","abundance":16.4,"rank":3148,"name":"Pfas","annotation":"Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate (By similarity); In the N-terminal section; belongs to the FGAMS family."},{"id":"ENSMUSP00000054548","abundance":16.4,"rank":3149,"name":"Poldip3","annotation":"Polymerase delta-interacting protein 3; Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA. Involved in nuclear mRNA export; probably mediated by association with the TREX complex (By similarity)."},{"id":"ENSMUSP00000039621","abundance":16.4,"rank":3150,"name":"Rfc3","annotation":"Replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1."},{"id":"ENSMUSP00000048284","abundance":16.4,"rank":3151,"name":"Cyp2c54","annotation":"Cytochrome P450 2C54; Metabolizes arachidonic acid mainly to 12- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000111241","abundance":16.4,"rank":3152,"name":"Ufd1","annotation":"Ubiquitin recognition factor in ER-associated degradation protein 1; Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1- VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-deriv [...] "},{"id":"ENSMUSP00000064129","abundance":16.4,"rank":3153,"name":"Ppp1r14b","annotation":"Protein phosphatase 1 regulatory subunit 14B; Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated."},{"id":"ENSMUSP00000112770","abundance":16.4,"rank":3154,"name":"Sycn","annotation":"Syncollin; Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues."},{"id":"ENSMUSP00000159045","abundance":16.4,"rank":3155,"name":"Emc10","annotation":"ER membrane protein complex subunit 10; Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways."},{"id":"ENSMUSP00000042283","abundance":16.3,"rank":3156,"name":"Supt16","annotation":"FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] "},{"id":"ENSMUSP00000022855","abundance":16.3,"rank":3157,"name":"Brix1","annotation":"Ribosome biogenesis protein BRX1 homolog; Required for biogenesis of the 60S ribosomal subunit. Belongs to the BRX1 family."},{"id":"ENSMUSP00000034300","abundance":16.3,"rank":3158,"name":"Hsbp1","annotation":"Heat shock factor-binding protein 1; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process (By similarity)."},{"id":"ENSMUSP00000023117","abundance":16.3,"rank":3159,"name":"Phf5a","annotation":"PHD finger-like domain-containing protein 5A; Involved with the PAF1 complex (PAF1C) in transcriptional elongation by RNA polymerase II, and in regulation of development and maintenance of embryonic stem cell (ESC) pluripotency. Required for maintenance of ESCs self-renewal and cellular reprogramming of stem cells. Maintains pluripotency by recruiting and stabilizing PAF1C on pluripotency genes loci, and by regulating the expression of the pluripotency genes. Regulates the deposition of elongation-associated histone modifications, including dimethylated histone H3 'Lys-79' (H3K79me2) a [...] "},{"id":"ENSMUSP00000103768","abundance":16.3,"rank":3160,"name":"Smim8","annotation":"Small integral membrane protein 8."},{"id":"ENSMUSP00000060524","abundance":16.3,"rank":3161,"name":"Cyp2d40","annotation":"Cytochrome P450, family 2, subfamily d, polypeptide 40; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000105141","abundance":16.3,"rank":3162,"name":"Cyp2d34","annotation":"Cytochrome P450, family 2, subfamily d, polypeptide 34; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000074195","abundance":16.3,"rank":3163,"name":"Acyp2","annotation":"Acylphosphatase-2."},{"id":"ENSMUSP00000027252","abundance":16.3,"rank":3164,"name":"Eif5b","annotation":"Eukaryotic translation initiation factor 5B; Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes."},{"id":"ENSMUSP00000047157","abundance":16.3,"rank":3165,"name":"Aqr","annotation":"RNA helicase aquarius; Involved in pre-mRNA splicing as component of the spliceosome. Intron-binding spliceosomal protein required to link pre- mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron- encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the [...] "},{"id":"ENSMUSP00000054731","abundance":16.3,"rank":3166,"name":"Spryd4","annotation":"SPRY domain-containing protein 4."},{"id":"ENSMUSP00000026899","abundance":16.3,"rank":3167,"name":"Slc25a10","annotation":"Mitochondrial dicarboxylate carrier; Involved in translocation of malonate, malate and succinate in exchange for phosphate, sulfate, sulfite or thiosulfate across mitochondrial inner membrane."},{"id":"ENSMUSP00000027766","abundance":16.3,"rank":3168,"name":"Coq8a","annotation":"Atypical kinase COQ8A, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). Shows an unusual selectivity for binding ADP over ATP (By similarity)."},{"id":"ENSMUSP00000058135","abundance":16.3,"rank":3169,"name":"Ephb2","annotation":"Ephrin type-B receptor 2; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral corte [...] "},{"id":"ENSMUSP00000157286","abundance":16.3,"rank":3170,"name":"Tpsb2","annotation":"Tryptase beta-2; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Plays a role in innate immunity."},{"id":"ENSMUSP00000031320","abundance":16.3,"rank":3171,"name":"Pf4","annotation":"Platelet factor 4; Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation (By similarity)."},{"id":"ENSMUSP00000027861","abundance":16.2,"rank":3172,"name":"Dpt","annotation":"Dermatopontin; Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity (By similarity). Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low- temperature dissociation; Belongs to the dermatopontin family."},{"id":"ENSMUSP00000019749","abundance":16.2,"rank":3173,"name":"Hoxd8","annotation":"Homeobox protein Hox-D8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family."},{"id":"ENSMUSP00000033671","abundance":16.2,"rank":3174,"name":"Rps6ka3","annotation":"Ribosomal protein S6 kinase alpha-3; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subseq [...] "},{"id":"ENSMUSP00000021726","abundance":16.2,"rank":3175,"name":"Adssl1","annotation":"Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. Belongs to the adenylosuccinate synthetase family."},{"id":"ENSMUSP00000019382","abundance":16.2,"rank":3176,"name":"Tecr","annotation":"Very-long-chain enoyl-CoA reductase; Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty aci [...] "},{"id":"ENSMUSP00000013559","abundance":16.2,"rank":3177,"name":"Igf2bp1","annotation":"Insulin-like growth factor 2 mRNA-binding protein 1; RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Regulates localized beta-actin/ACTB mRNA translation, a crucial process for cell polarity, cell migration and neurite outgrowth. Co-transcriptionally associates with the ACTB mR [...] "},{"id":"ENSMUSP00000012355","abundance":16.2,"rank":3178,"name":"Tex22","annotation":"Testis-expressed protein 22."},{"id":"ENSMUSP00000109884","abundance":16.2,"rank":3179,"name":"Fzd7","annotation":"Frizzled-7; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to invo [...] "},{"id":"ENSMUSP00000139347","abundance":16.2,"rank":3180,"name":"Tac1","annotation":"C-terminal-flanking peptide; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles; Belongs to the tachykinin family."},{"id":"ENSMUSP00000032264","abundance":16.2,"rank":3181,"name":"Gabarapl1","annotation":"Gamma-aminobutyric acid receptor-associated protein-like 1; Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity)."},{"id":"ENSMUSP00000141400","abundance":16.2,"rank":3182,"name":"Map4k4","annotation":"Mitogen-activated protein kinase kinase kinase kinase 4; Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322 (By similarity); Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily."},{"id":"ENSMUSP00000039114","abundance":16.1,"rank":3183,"name":"Akr1b10","annotation":"Aldo-keto reductase family 1, member B10 (aldose reductase)."},{"id":"ENSMUSP00000004389","abundance":16.1,"rank":3184,"name":"Grcc10","annotation":"Protein C10; In brain, may be required for corpus callosum development. Belongs to the UPF0456 family."},{"id":"ENSMUSP00000103262","abundance":16.1,"rank":3185,"name":"Prr15l","annotation":"Proline-rich protein 15-like protein; Belongs to the PRR15 family."},{"id":"ENSMUSP00000006027","abundance":16.1,"rank":3186,"name":"Reep5","annotation":"Receptor expression-enhancing protein 5; May promote functional cell surface expression of olfactory receptors; Belongs to the DP1 family."},{"id":"ENSMUSP00000028781","abundance":16.1,"rank":3187,"name":"Atrn","annotation":"Attractin; Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity). May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti. Has a critical role in normal myelination in the central nervous system (By similarity)."},{"id":"ENSMUSP00000003450","abundance":16.1,"rank":3188,"name":"Ddx23","annotation":"DEAD (Asp-Glu-Ala-Asp) box polypeptide 23."},{"id":"ENSMUSP00000096745","abundance":16.1,"rank":3189,"name":"Tgif2","annotation":"Homeobox protein TGIF2; Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins (By similarity); Belongs to the TALE/TGIF homeobox family."},{"id":"ENSMUSP00000029975","abundance":16.1,"rank":3190,"name":"Cga","annotation":"Glycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways."},{"id":"ENSMUSP00000078175","abundance":16.1,"rank":3191,"name":"Plekhb1","annotation":"Pleckstrin homology domain-containing family B member 1."},{"id":"ENSMUSP00000095843","abundance":16.1,"rank":3192,"name":"Ggh","annotation":"Gamma-glutamyl hydrolase; Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Acts as endopeptidase. Lysosomal enzyme is activated by sulfhydryl compounds."},{"id":"ENSMUSP00000026479","abundance":16.1,"rank":3193,"name":"Dctn2","annotation":"Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development; Belongs to the dynactin subunit 2 family."},{"id":"ENSMUSP00000012028","abundance":16.1,"rank":3194,"name":"Gltp","annotation":"Glycolipid transfer protein; Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides (By similarity)."},{"id":"ENSMUSP00000021530","abundance":16.1,"rank":3195,"name":"Hif1a","annotation":"Hypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Heterodimerizes with ARNT; heterodimer binds to core DNA sequenc [...] "},{"id":"ENSMUSP00000136790","abundance":16.1,"rank":3196,"name":"Ighv6-5","annotation":"Ig heavy chain V-III region J606."},{"id":"ENSMUSP00000057375","abundance":16.1,"rank":3197,"name":"Golph3","annotation":"Golgi phosphoprotein 3; Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Has also been involved in the control of the localization of Golgi enzymes through inter [...] "},{"id":"ENSMUSP00000125746","abundance":16,"rank":3198,"name":"Krr1","annotation":"KRR1 small subunit processome component homolog; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)."},{"id":"ENSMUSP00000130221","abundance":16,"rank":3199,"name":"Sin3a","annotation":"Paired amphipathic helix protein Sin3a; Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates wi [...] "},{"id":"ENSMUSP00000025542","abundance":16,"rank":3200,"name":"Psat1","annotation":"Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine."},{"id":"ENSMUSP00000085253","abundance":16,"rank":3201,"name":"Rab44","annotation":"Ras-related protein Rab-44."},{"id":"ENSMUSP00000040756","abundance":16,"rank":3202,"name":"Atp6v1h","annotation":"V-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Involved in the endocytosis mediated by clathrin- coated pits, required for the formation of endosomes (By similarity)."},{"id":"ENSMUSP00000065271","abundance":16,"rank":3203,"name":"Mettl7a1","annotation":"Methyltransferase-like 7A1."},{"id":"ENSMUSP00000100902","abundance":16,"rank":3204,"name":"Cnot2","annotation":"CCR4-NOT transcription complex subunit 2; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4- NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may s [...] "},{"id":"ENSMUSP00000081009","abundance":16,"rank":3205,"name":"Sephs2","annotation":"Selenide, water dikinase 2; Synthesizes selenophosphate from selenide and ATP; Belongs to the selenophosphate synthase 1 family. Class I subfamily."},{"id":"ENSMUSP00000103884","abundance":16,"rank":3206,"name":"Prkci","annotation":"Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process  [...] "},{"id":"ENSMUSP00000000175","abundance":15.9,"rank":3207,"name":"Sdhd","annotation":"Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family."},{"id":"ENSMUSP00000142079","abundance":15.9,"rank":3208,"name":"Pfkfb3","annotation":"6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 splice variant 2."},{"id":"ENSMUSP00000074756","abundance":15.9,"rank":3209,"name":"Exosc1","annotation":"Exosome complex component CSL4; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytop [...] "},{"id":"ENSMUSP00000045409","abundance":15.9,"rank":3210,"name":"Ogt","annotation":"UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N- acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Probably by glycosylating  [...] "},{"id":"ENSMUSP00000027743","abundance":15.9,"rank":3211,"name":"Stx6","annotation":"Syntaxin-6; Involved in intracellular vesicle trafficking; Belongs to the syntaxin family."},{"id":"ENSMUSP00000047173","abundance":15.9,"rank":3212,"name":"Pdlim7","annotation":"PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)."},{"id":"ENSMUSP00000062841","abundance":15.8,"rank":3213,"name":"Them4","annotation":"Acyl-coenzyme A thioesterase THEM4; Has acyl-CoA thioesterase activity towards medium and long- chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism (By similarity). Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity."},{"id":"ENSMUSP00000090886","abundance":15.8,"rank":3214,"name":"Pard6a","annotation":"Partitioning defective 6 homolog alpha; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (By similarity)."},{"id":"ENSMUSP00000023087","abundance":15.8,"rank":3215,"name":"Twf1","annotation":"Twinfilin-1; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles."},{"id":"ENSMUSP00000102716","abundance":15.8,"rank":3216,"name":"Bola1","annotation":"BolA-like protein 1; Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins (By similarity). Probably acts together with the monothiol glutaredoxin GLRX5. May protect cells against oxidative stress (By similarity)."},{"id":"ENSMUSP00000086716","abundance":15.8,"rank":3217,"name":"Usp9x","annotation":"Probable ubiquitin carboxyl-terminal hydrolase FAF-X; Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'- linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinat [...] "},{"id":"ENSMUSP00000027792","abundance":15.8,"rank":3218,"name":"Srp9","annotation":"Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding."},{"id":"ENSMUSP00000003754","abundance":15.8,"rank":3219,"name":"Calb2","annotation":"Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons."},{"id":"ENSMUSP00000003569","abundance":15.8,"rank":3220,"name":"Inmt","annotation":"Indolethylamine N-methyltransferase; Catalyzes the N-methylation of tryptamine and structurally related compounds (By similarity). Functions as thioether S- methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3- methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2- methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNM [...] "},{"id":"ENSMUSP00000032500","abundance":15.7,"rank":3221,"name":"Prmt8","annotation":"Protein arginine N-methyltransferase 8; S-adenosyl-L-methionine-dependent and membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA) in proteins such as NIFK, myelin basic protein, histone H4, H2A and H2A/H2B dimer. Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT8 subfamily."},{"id":"ENSMUSP00000032203","abundance":15.7,"rank":3222,"name":"A2m","annotation":"Alpha-2-macroglobulin-P; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the  [...] "},{"id":"ENSMUSP00000031472","abundance":15.7,"rank":3223,"name":"Pxmp2","annotation":"Peroxisomal membrane protein 2; Seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane."},{"id":"ENSMUSP00000021405","abundance":15.7,"rank":3224,"name":"Polr2h","annotation":"DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity)."},{"id":"ENSMUSP00000086701","abundance":15.7,"rank":3225,"name":"Uba3","annotation":"NEDD8-activating enzyme E1 catalytic subunit; Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down- regulates steroid receptor activity. Necessary for cell cycle progression."},{"id":"ENSMUSP00000070868","abundance":15.7,"rank":3226,"name":"Pla2g4a","annotation":"Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response."},{"id":"ENSMUSP00000003268","abundance":15.7,"rank":3227,"name":"Sh3gl1","annotation":"Endophilin-A2; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity)."},{"id":"ENSMUSP00000089459","abundance":15.7,"rank":3228,"name":"Akr1e1","annotation":"1,5-anhydro-D-fructose reductase; Catalyzes the NADPH-dependent reduction of 1,5-anhydro-D- fructose (AF) to 1,5-anhydro-D-glucitol; Belongs to the aldo/keto reductase family."},{"id":"ENSMUSP00000130115","abundance":15.7,"rank":3229,"name":"Smad2","annotation":"Mothers against decapentaplegic homolog 2; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator [...] "},{"id":"ENSMUSP00000093843","abundance":15.7,"rank":3230,"name":"Il1rap","annotation":"Interleukin-1 receptor accessory protein; Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL [...] "},{"id":"ENSMUSP00000028944","abundance":15.7,"rank":3231,"name":"Acss1","annotation":"Acetyl-coenzyme A synthetase 2-like, mitochondrial; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate. Can also utilize propionate with a much lower affinity. Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions. Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient."},{"id":"ENSMUSP00000025106","abundance":15.7,"rank":3232,"name":"Polr2d","annotation":"DNA-directed RNA polymerase II subunit RPB4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB4 is part of a subcomplex with RPB7 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems  [...] "},{"id":"ENSMUSP00000103514","abundance":15.7,"rank":3233,"name":"Akt1s1","annotation":"Proline-rich AKT1 substrate 1; Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1- TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis [...] "},{"id":"ENSMUSP00000024706","abundance":15.6,"rank":3234,"name":"Pla2g7","annotation":"Platelet-activating factor acetylhydrolase; Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids; Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000022428","abundance":15.6,"rank":3235,"name":"Rnase4","annotation":"Ribonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Belongs to the pancreatic ribonuclease family."},{"id":"ENSMUSP00000127249","abundance":15.6,"rank":3236,"name":"Iqsec2","annotation":"IQ motif and SEC7 domain-containing protein 2; Is a guanine nucleotide exchange factor for the ARF GTP- binding proteins; Belongs to the BRAG family."},{"id":"ENSMUSP00000033543","abundance":15.6,"rank":3237,"name":"Cmc4","annotation":"Cx9C motif-containing protein 4."},{"id":"ENSMUSP00000046296","abundance":15.6,"rank":3238,"name":"Fmnl1","annotation":"Formin-like protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape. May play a role in the control of cell motility and survival of macrophages."},{"id":"ENSMUSP00000020741","abundance":15.6,"rank":3239,"name":"Drg1","annotation":"Developmentally-regulated GTP-binding protein 1; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C- 3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these mi [...] "},{"id":"ENSMUSP00000060202","abundance":15.6,"rank":3240,"name":"Uck2","annotation":"Uridine-cytidine kinase 2; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6- azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)- acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (By similarity)."},{"id":"ENSMUSP00000099375","abundance":15.6,"rank":3241,"name":"Itga2b","annotation":"Integrin alpha-IIb heavy chain; Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface."},{"id":"ENSMUSP00000099421","abundance":15.6,"rank":3242,"name":"Krt222","annotation":"Keratin-like protein KRT222."},{"id":"ENSMUSP00000130201","abundance":15.6,"rank":3243,"name":"Clasp2","annotation":"CLIP-associating protein 2; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at le [...] "},{"id":"ENSMUSP00000001724","abundance":15.5,"rank":3244,"name":"Ddx18","annotation":"ATP-dependent RNA helicase DDX18; Probable RNA-dependent helicase; Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily."},{"id":"ENSMUSP00000099512","abundance":15.5,"rank":3245,"name":"Spaca3","annotation":"Sperm acrosome membrane-associated protein 3, processed form; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N- acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro (By similarity); Belongs to the glycosyl hydrolase 22 family."},{"id":"ENSMUSP00000022849","abundance":15.5,"rank":3246,"name":"Tars","annotation":"Threonine--tRNA ligase 1, cytoplasmic; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post- transfer stage; Belongs to the class-II aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000093961","abundance":15.5,"rank":3247,"name":"Rom1","annotation":"Rod outer segment membrane protein 1; Plays a role in rod outer segment (ROS) morphogenesis. May play a role with PRPH2 in the maintenance of the structure of ROS curved disks (By similarity). Plays a role in the organization of the ROS and maintenance of ROS disk diameter. Involved in the maintenance of the retina outer nuclear layer."},{"id":"ENSMUSP00000016033","abundance":15.5,"rank":3248,"name":"Lta4h","annotation":"Leukotriene A-4 hydrolase; Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity."},{"id":"ENSMUSP00000038232","abundance":15.5,"rank":3249,"name":"Lcat","annotation":"Phosphatidylcholine-sterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal  [...] "},{"id":"ENSMUSP00000099506","abundance":15.5,"rank":3250,"name":"Pex14","annotation":"Peroxisomal membrane protein PEX14; Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin."},{"id":"ENSMUSP00000136977","abundance":15.5,"rank":3251,"name":"Mapk9","annotation":"Mitogen-activated protein kinase 9; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress- activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as J [...] "},{"id":"ENSMUSP00000030787","abundance":15.5,"rank":3252,"name":"Rheb","annotation":"GTP-binding protein Rheb; Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity."},{"id":"ENSMUSP00000029876","abundance":15.4,"rank":3253,"name":"Calb1","annotation":"Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase."},{"id":"ENSMUSP00000007255","abundance":15.4,"rank":3254,"name":"Ddah2","annotation":"N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation (By similarity)."},{"id":"ENSMUSP00000008579","abundance":15.4,"rank":3255,"name":"Rdh13","annotation":"Retinol dehydrogenase 13; Retinol dehydrogenase with a clear preference for NADP. Oxidizes all-trans-retinol, but seems to reduce all-trans-retinal with much higher efficiency. Has no activity towards steroid. Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000019506","abundance":15.4,"rank":3256,"name":"D8Ertd738e","annotation":"Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy."},{"id":"ENSMUSP00000031793","abundance":15.4,"rank":3257,"name":"Nt5c3","annotation":"Cytosolic 5'-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate; Belongs to the pyrimidine 5'-nucleotidase family."},{"id":"ENSMUSP00000089793","abundance":15.4,"rank":3258,"name":"Col11a1","annotation":"Collagen alpha-1(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Belongs to the fibrillar collagen family."},{"id":"ENSMUSP00000060433","abundance":15.4,"rank":3259,"name":"Shb","annotation":"SH2 domain-containing adapter protein B; Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin- producing cells (By similarity)."},{"id":"ENSMUSP00000073957","abundance":15.4,"rank":3260,"name":"Osbpl1a","annotation":"Oxysterol-binding protein-related protein 1; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol."},{"id":"ENSMUSP00000095882","abundance":15.4,"rank":3261,"name":"Omp","annotation":"Olfactory marker protein; May act as a modulator of the olfactory signal-transduction cascade; Belongs to the olfactory marker protein family."},{"id":"ENSMUSP00000013931","abundance":15.4,"rank":3262,"name":"Ehmt2","annotation":"Histone-lysine N-methyltransferase EHMT2; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltr [...] "},{"id":"ENSMUSP00000044924","abundance":15.3,"rank":3263,"name":"Dhrs7b","annotation":"Dehydrogenase/reductase SDR family member 7B; Putative oxidoreductase."},{"id":"ENSMUSP00000054858","abundance":15.3,"rank":3264,"name":"Isca1","annotation":"Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly."},{"id":"ENSMUSP00000038350","abundance":15.3,"rank":3265,"name":"Scamp2","annotation":"Secretory carrier-associated membrane protein 2; Functions in post-Golgi recycling pathways. Acts as a recycling carrier to the cell surface (By similarity)."},{"id":"ENSMUSP00000023769","abundance":15.3,"rank":3266,"name":"Atf1","annotation":"Cyclic AMP-dependent transcription factor ATF-1; Binds the cAMP response element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation (By similarity); Belongs to the bZIP family. ATF subfamily."},{"id":"ENSMUSP00000038305","abundance":15.3,"rank":3267,"name":"Mrps28","annotation":"28S ribosomal protein S28, mitochondrial; Belongs to the bacterial ribosomal protein bS1 family."},{"id":"ENSMUSP00000104301","abundance":15.3,"rank":3268,"name":"Chd3","annotation":"Chromodomain helicase DNA-binding protein 3."},{"id":"ENSMUSP00000048925","abundance":15.3,"rank":3269,"name":"Vwa8","annotation":"Von Willebrand factor A domain-containing protein 8; Exhibits ATPase activity in vitro."},{"id":"ENSMUSP00000069257","abundance":15.3,"rank":3270,"name":"Ppp1r12a","annotation":"Protein phosphatase 1 regulatory subunit 12A; Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity (By similarity)."},{"id":"ENSMUSP00000099790","abundance":15.3,"rank":3271,"name":"Eps15","annotation":"Epidermal growth factor receptor substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internaliz [...] "},{"id":"ENSMUSP00000111381","abundance":15.3,"rank":3272,"name":"Psd2","annotation":"PH and SEC7 domain-containing protein 2; Belongs to the PSD family."},{"id":"ENSMUSP00000033372","abundance":15.3,"rank":3273,"name":"Rp2","annotation":"Protein XRP2; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins."},{"id":"ENSMUSP00000126733","abundance":15.2,"rank":3274,"name":"Dctd","annotation":"Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase."},{"id":"ENSMUSP00000080389","abundance":15.2,"rank":3275,"name":"Srgap1","annotation":"SLIT-ROBO Rho GTPase-activating protein 1; GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42 (By similarity)."},{"id":"ENSMUSP00000125509","abundance":15.2,"rank":3276,"name":"Tbc1d4","annotation":"TBC1 domain family member 4; May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake (By similarity)."},{"id":"ENSMUSP00000025835","abundance":15.2,"rank":3277,"name":"Cpt1a","annotation":"Carnitine O-palmitoyltransferase 1, liver isoform; Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism; Belongs to the carnitine/choline acetyltransferase family."},{"id":"ENSMUSP00000007733","abundance":15.2,"rank":3278,"name":"Tinf2","annotation":"TERF1-interacting nuclear factor 2; Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly (By similarity)."},{"id":"ENSMUSP00000030018","abundance":15.2,"rank":3279,"name":"Nans","annotation":"Sialic acid synthase; Produces N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) from N- acetylmannosamine 6-phosphate. Has no detectable activity towards N- acetylmannosamine or mannose 6-phosphate."},{"id":"ENSMUSP00000155142","abundance":15.2,"rank":3280,"name":"Nudt16l1","annotation":"Tudor-interacting repair regulator protein; Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain an [...] "},{"id":"ENSMUSP00000054421","abundance":15.2,"rank":3281,"name":"Eif3j2","annotation":"Eukaryotic translation initiation factor 3 subunit J-B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination rib [...] "},{"id":"ENSMUSP00000034903","abundance":15.2,"rank":3282,"name":"Gsta4","annotation":"Glutathione S-transferase A4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles."},{"id":"ENSMUSP00000023312","abundance":15.2,"rank":3283,"name":"Alcam","annotation":"CD166 antigen; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube f [...] "},{"id":"ENSMUSP00000005532","abundance":15.2,"rank":3284,"name":"Nid1","annotation":"Nidogen-1; Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions."},{"id":"ENSMUSP00000031183","abundance":15.2,"rank":3285,"name":"Ugt2b1","annotation":"UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000077532","abundance":15.1,"rank":3286,"name":"Ppp3cc","annotation":"Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32."},{"id":"ENSMUSP00000117304","abundance":15.1,"rank":3287,"name":"Cnot7","annotation":"CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] "},{"id":"ENSMUSP00000029125","abundance":15.1,"rank":3288,"name":"Armc1","annotation":"Armadillo repeat-containing protein 1."},{"id":"ENSMUSP00000100547","abundance":15.1,"rank":3289,"name":"AK157302","annotation":"cDNA sequence AK157302."},{"id":"ENSMUSP00000062670","abundance":15.1,"rank":3290,"name":"Pon2","annotation":"Serum paraoxonase/arylesterase 2; Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters; Belongs to the paraoxonase family."},{"id":"ENSMUSP00000019577","abundance":15.1,"rank":3291,"name":"Gipc1","annotation":"PDZ domain-containing protein GIPC1; Inhibits endothelial cell migration (in vitro). May be involved in G protein-linked signaling (By similarity); Belongs to the GIPC family."},{"id":"ENSMUSP00000052776","abundance":15.1,"rank":3292,"name":"Eps8","annotation":"Epidermal growth factor receptor kinase substrate 8; Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and acti [...] "},{"id":"ENSMUSP00000037576","abundance":15.1,"rank":3293,"name":"Sv2a","annotation":"Synaptic vesicle glycoprotein 2A; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E. Belongs to the major facilitator superfamily."},{"id":"ENSMUSP00000103039","abundance":15.1,"rank":3294,"name":"Krt36","annotation":"Keratin, type I cuticular Ha6; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000021903","abundance":15.1,"rank":3295,"name":"Gadd45g","annotation":"Growth arrest and DNA damage-inducible protein GADD45 gamma; Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK; Belongs to the GADD45 family."},{"id":"ENSMUSP00000035366","abundance":15.1,"rank":3296,"name":"Dync1li1","annotation":"Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkp [...] "},{"id":"ENSMUSP00000060169","abundance":15.1,"rank":3297,"name":"Igfals","annotation":"Insulin-like growth factor-binding protein complex acid labile subunit; May have an important role in regulating the access of circulating IGFs to the tissues."},{"id":"ENSMUSP00000096492","abundance":15.1,"rank":3298,"name":"Defa3","annotation":"Defensin, alpha, 3."},{"id":"ENSMUSP00000078485","abundance":15.1,"rank":3299,"name":"Defa17","annotation":"Alpha-defensin 3; Probably contributes to the antimicrobial barrier function of the small bowel mucosa."},{"id":"ENSMUSP00000139143","abundance":15,"rank":3300,"name":"Pin1rt1","annotation":"Peptidyl-prolyl cis-trans isomerase."},{"id":"ENSMUSP00000003445","abundance":15,"rank":3301,"name":"Fkbp11","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP11; PPIases accelerate the folding of proteins during protein synthesis; Belongs to the FKBP-type PPIase family."},{"id":"ENSMUSP00000002397","abundance":15,"rank":3302,"name":"Gmpr2","annotation":"GMP reductase 2; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (Probable). Plays a role in modulating cellular differentiation (By similarity)."},{"id":"ENSMUSP00000027256","abundance":15,"rank":3303,"name":"Mrpl30","annotation":"39S ribosomal protein L30, mitochondrial; Belongs to the universal ribosomal protein uL30 family."},{"id":"ENSMUSP00000106851","abundance":15,"rank":3304,"name":"Cadm3","annotation":"Cell adhesion molecule 3; Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions; Belongs to the nectin family."},{"id":"ENSMUSP00000064048","abundance":15,"rank":3305,"name":"Ptprs","annotation":"Receptor-type tyrosine-protein phosphatase S; Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain develop [...] "},{"id":"ENSMUSP00000052866","abundance":15,"rank":3306,"name":"Pgp","annotation":"Glycerol-3-phosphate phosphatase; Glycerol-3-phosphate phosphatase hydrolyzing glycerol-3- phosphate into glycerol. Thereby, regulates the cellular levels of glycerol-3-phosphate a metabolic intermediate of glucose, lipid and energy metabolism. Was also shown to have a 2- phosphoglycolate phosphatase activity and a tyrosine-protein phosphatase activity. However, their physiological relevance is unclear. In vitro, has also a phosphatase activity toward ADP, ATP, GDP and GTP."},{"id":"ENSMUSP00000034392","abundance":15,"rank":3307,"name":"Nip7","annotation":"60S ribosome subunit biogenesis protein NIP7 homolog; Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly."},{"id":"ENSMUSP00000025745","abundance":15,"rank":3308,"name":"Mrpl21","annotation":"39S ribosomal protein L21, mitochondrial."},{"id":"ENSMUSP00000078659","abundance":15,"rank":3309,"name":"En1","annotation":"Homeobox protein engrailed-1."},{"id":"ENSMUSP00000129712","abundance":15,"rank":3310,"name":"Ghitm","annotation":"Growth hormone-inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c (By similarity)."},{"id":"ENSMUSP00000034860","abundance":15,"rank":3311,"name":"Cyp1a2","annotation":"Cytochrome P450 1A2; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E [...] "},{"id":"ENSMUSP00000110729","abundance":15,"rank":3312,"name":"Abcb8","annotation":"Mitochondrial potassium channel ATP-binding subunit; ATP-binding subunit of the mitochondrial potassium channel located in the mitochondrial inner membrane (By similarity). Together with CCDC51/MITOK, forms a protein complex localized in the mitochondria that mediates ATP-dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel) (By similarity). Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-conta [...] "},{"id":"ENSMUSP00000059889","abundance":14.9,"rank":3313,"name":"Acpp","annotation":"Prostatic acid phosphatase; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (By similarity); Belongs to the histidine acid phosphatase family."},{"id":"ENSMUSP00000023217","abundance":14.9,"rank":3314,"name":"Bop1","annotation":"Ribosome biogenesis protein BOP1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome."},{"id":"ENSMUSP00000032425","abundance":14.9,"rank":3315,"name":"Emc3","annotation":"ER membrane protein complex subunit 3; Belongs to the EMC3 family."},{"id":"ENSMUSP00000131163","abundance":14.9,"rank":3316,"name":"G6pd2","annotation":"Glucose-6-phosphate 1-dehydrogenase 2; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes."},{"id":"ENSMUSP00000044665","abundance":14.9,"rank":3317,"name":"Crp","annotation":"C-reactive protein; Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells; Belongs to the pentraxin family."},{"id":"ENSMUSP00000028768","abundance":14.9,"rank":3318,"name":"Ndufaf1","annotation":"Complex I intermediate-associated protein 30, mitochondrial; Chaperone protein involved in early stages of the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)."},{"id":"ENSMUSP00000023752","abundance":14.9,"rank":3319,"name":"Aqp2","annotation":"Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Plays an essential role in renal water homeostasis."},{"id":"ENSMUSP00000044877","abundance":14.9,"rank":3320,"name":"Bet1","annotation":"BET1 homolog; Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER- derived vesicles with the cis-Golgi membrane (By similarity)."},{"id":"ENSMUSP00000129789","abundance":14.9,"rank":3321,"name":"Pym1","annotation":"Partner of Y14 and mago; Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon- exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translatio [...] "},{"id":"ENSMUSP00000104992","abundance":14.9,"rank":3322,"name":"Slpi","annotation":"Antileukoproteinase; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. Modulates the innate immune response after bacterial infection. Contributes to regulate the inflammatory and immune responses to the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses. Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. R [...] "},{"id":"ENSMUSP00000140106","abundance":14.9,"rank":3323,"name":"Uchl5","annotation":"Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity); Belongs to the peptidase C12 family."},{"id":"ENSMUSP00000053558","abundance":14.9,"rank":3324,"name":"Abhd12","annotation":"Lysophosphatidylserine lipase ABHD12; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoyl [...] "},{"id":"ENSMUSP00000048078","abundance":14.9,"rank":3325,"name":"Mrpl47","annotation":"39S ribosomal protein L47, mitochondrial; Belongs to the universal ribosomal protein uL29 family."},{"id":"ENSMUSP00000026211","abundance":14.9,"rank":3326,"name":"Cyp2c23","annotation":"Cytochrome P450 2C44; A cytochrome P450 monooxygenase involved in polyunsaturated fatty acids (PUFAs) metabolism and signaling. Catalyzes preferentially the epoxidation of double bonds of PUFAs. Converts arachidonoic acid primarily to stereospecific products (8R,9S)-epoxyeicosatrienoate (EET) and (11R,12S)-EET. Via EETs may inhibit the epithelial sodium channels in nephron segments, leading to increased sodium excretion and stable systemic blood pressure. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, wi [...] "},{"id":"ENSMUSP00000031287","abundance":14.8,"rank":3327,"name":"Tpst2","annotation":"Protein-tyrosine sulfotransferase 2; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate."},{"id":"ENSMUSP00000076564","abundance":14.8,"rank":3328,"name":"Rnpep","annotation":"Aminopeptidase B; Exopeptidase which selectively removes arginine and/or lysine residues from the N-terminus of several peptide substrates including Arg(0)-Leu-enkephalin, Arg(0)-Met-enkephalin and Arg(-1)-Lys(0)- somatostatin-14. Can hydrolyze leukotriene A4 (LTA-4) into leukotriene B4 (LTB-4) (By similarity)."},{"id":"ENSMUSP00000077996","abundance":14.8,"rank":3329,"name":"Zfp706","annotation":"Zinc finger protein 706; Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4."},{"id":"ENSMUSP00000084466","abundance":14.8,"rank":3330,"name":"Cnot9","annotation":"CCR4-NOT transcription complex subunit 9; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down- regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Required for retinoic acid-induced differentiation of F9 teratocar [...] "},{"id":"ENSMUSP00000021635","abundance":14.8,"rank":3331,"name":"Akr1c18","annotation":"Aldo-keto reductase family 1 member C18; Catalyzes the conversion of progesterone into 20-alpha- dihydroprogesterone (20 alpha-OHP); Belongs to the aldo/keto reductase family."},{"id":"ENSMUSP00000028280","abundance":14.8,"rank":3332,"name":"Col5a1","annotation":"Collagen alpha-1(V) chain; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). Transcriptionally activated by CEBPZ, which recognizes a CCAAT-like motif, CAAAT in the COL5A1 promoter."},{"id":"ENSMUSP00000061092","abundance":14.8,"rank":3333,"name":"Mtap","annotation":"S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates."},{"id":"ENSMUSP00000050001","abundance":14.8,"rank":3334,"name":"Ccny","annotation":"Cyclin-Y; Positive regulatory subunit of the cyclin-dependent kinase CDK14/PFTK1. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway (By similarity). Recruits CDK16 to the plasma membrane (By similarity). Positive regulatory subunit of the cyclin- dependent kinase CDK16."},{"id":"ENSMUSP00000037210","abundance":14.8,"rank":3335,"name":"Git1","annotation":"ARF GTPase-activating protein GIT1; GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes (By similarity). Involved in the regulation of cytokinesis; the function may invol [...] "},{"id":"ENSMUSP00000110489","abundance":14.8,"rank":3336,"name":"Thy1","annotation":"Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain."},{"id":"ENSMUSP00000112250","abundance":14.8,"rank":3337,"name":"Trmt112","annotation":"Multifunctional methyltransferase subunit TRM112-like protein; Acts as an activator of both rRNA/tRNA and protein methyltransferases. Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (By similarity). The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (By similarity). Involved in the pre- [...] "},{"id":"ENSMUSP00000121358","abundance":14.8,"rank":3338,"name":"Ide","annotation":"Insulin-degrading enzyme; Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation and clearance of A [...] "},{"id":"ENSMUSP00000030399","abundance":14.8,"rank":3339,"name":"Rragc","annotation":"Ras-related GTP-binding protein C; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (By similarity)."},{"id":"ENSMUSP00000083928","abundance":14.8,"rank":3340,"name":"Man2a1","annotation":"Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway. Belongs to the glycosyl hydrolase 38 family."},{"id":"ENSMUSP00000025862","abundance":14.7,"rank":3341,"name":"Smarca2","annotation":"Probable global transcription activator SNF2L2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural develop [...] "},{"id":"ENSMUSP00000107690","abundance":14.7,"rank":3342,"name":"Shisa5","annotation":"Protein shisa-5; Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis."},{"id":"ENSMUSP00000077856","abundance":14.7,"rank":3343,"name":"Vps28","annotation":"Vacuolar protein sorting-associated protein 28 homolog; Component of the ESCRT-I complex, a regulator of vesicular trafficking process; Belongs to the VPS28 family."},{"id":"ENSMUSP00000046340","abundance":14.7,"rank":3344,"name":"Grn","annotation":"Paragranulin; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes. Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell prolifera [...] "},{"id":"ENSMUSP00000003971","abundance":14.7,"rank":3345,"name":"Lin7b","annotation":"Protein lin-7 homolog B; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may funct [...] "},{"id":"ENSMUSP00000028179","abundance":14.7,"rank":3346,"name":"Fcnb","annotation":"Ficolin-2; May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin (By similarity); Belongs to the ficolin lectin family."},{"id":"ENSMUSP00000069525","abundance":14.7,"rank":3347,"name":"Tchh","annotation":"Trichohyalin."},{"id":"ENSMUSP00000014339","abundance":14.7,"rank":3348,"name":"Dnajc7","annotation":"DnaJ homolog subfamily C member 7; Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes (By similarity). Recruits NR1I3 to the cytoplasm."},{"id":"ENSMUSP00000007042","abundance":14.7,"rank":3349,"name":"Ik","annotation":"Protein Red; Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species. Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1."},{"id":"ENSMUSP00000003620","abundance":14.7,"rank":3350,"name":"Prodh","annotation":"Proline dehydrogenase 1, mitochondrial; Converts proline to delta-1-pyrroline-5-carboxylate."},{"id":"ENSMUSP00000019937","abundance":14.7,"rank":3351,"name":"Sec63","annotation":"Translocation protein SEC63 homolog; Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen (By similarity). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane [...] "},{"id":"ENSMUSP00000021077","abundance":14.7,"rank":3352,"name":"Slc9a3r1","annotation":"Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling (By similarity). May participate in HTR4 targeting to microvilli. Involved in the regulation of  [...] "},{"id":"ENSMUSP00000006392","abundance":14.7,"rank":3353,"name":"Serpinb9b","annotation":"Serine (or cysteine) peptidase inhibitor, clade B, member 9b; Belongs to the serpin family."},{"id":"ENSMUSP00000018403","abundance":14.6,"rank":3354,"name":"Prl8a2","annotation":"Prolactin family 8, subfamily a, member 2."},{"id":"ENSMUSP00000048416","abundance":14.6,"rank":3355,"name":"Cops4","annotation":"COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] "},{"id":"ENSMUSP00000059210","abundance":14.6,"rank":3356,"name":"Maml1","annotation":"Mastermind-like protein 1; Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions."},{"id":"ENSMUSP00000079376","abundance":14.6,"rank":3357,"name":"Defa24","annotation":"Alpha-defensin 24; May have microbicidal activities; Belongs to the alpha-defensin family."},{"id":"ENSMUSP00000151244","abundance":14.6,"rank":3358,"name":"Usp15","annotation":"Ubiquitin carboxyl-terminal hydrolase 15; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta r [...] "},{"id":"ENSMUSP00000046497","abundance":14.6,"rank":3359,"name":"Acad12","annotation":"Acyl-Coenzyme A dehydrogenase family, member 12."},{"id":"ENSMUSP00000027657","abundance":14.6,"rank":3360,"name":"C4bp","annotation":"C4b-binding protein; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with serum amyloid P component."},{"id":"ENSMUSP00000005548","abundance":14.6,"rank":3361,"name":"Hmox1","annotation":"Heme oxygenase 1; Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis."},{"id":"ENSMUSP00000004054","abundance":14.6,"rank":3362,"name":"Kpna1","annotation":"Importin subunit alpha-5; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] "},{"id":"ENSMUSP00000018353","abundance":14.6,"rank":3363,"name":"Stk4","annotation":"Serine/threonine-protein kinase 4 18kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] "},{"id":"ENSMUSP00000061134","abundance":14.6,"rank":3364,"name":"Lkaaear1","annotation":"Protein LKAAEAR1."},{"id":"ENSMUSP00000137563","abundance":14.6,"rank":3365,"name":"Gm2056","annotation":"Predicted gene 2056; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000152437","abundance":14.6,"rank":3366,"name":"Gm21936","annotation":"Predicted gene, 21936; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000136709","abundance":14.6,"rank":3367,"name":"Gm8332","annotation":"Predicted pseudogene 8332."},{"id":"ENSMUSP00000105780","abundance":14.6,"rank":3368,"name":"Gm8300","annotation":"Predicted pseudogene 8332; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000152828","abundance":14.6,"rank":3369,"name":"Gm5788","annotation":"Predicted pseudogene 5788; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000137146","abundance":14.6,"rank":3370,"name":"Gm2035","annotation":"Predicted pseudogene 2035; Belongs to the eIF-1A family."},{"id":"ENSMUSP00000085632","abundance":14.6,"rank":3371,"name":"Acrbp","annotation":"Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin."},{"id":"ENSMUSP00000031697","abundance":14.6,"rank":3372,"name":"Cul1","annotation":"Cullin-1; Core component of multiple cullin-RING-based SCF (SKP1-CUL1- F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the  [...] "},{"id":"ENSMUSP00000069416","abundance":14.5,"rank":3373,"name":"Itgb5","annotation":"Integrin beta-5; Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand."},{"id":"ENSMUSP00000110586","abundance":14.5,"rank":3374,"name":"Slc25a14","annotation":"Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000081003","abundance":14.5,"rank":3375,"name":"mt-Cytb","annotation":"Cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis."},{"id":"ENSMUSP00000102546","abundance":14.5,"rank":3376,"name":"Dnajc6","annotation":"Putative tyrosine-protein phosphatase auxilin; Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin- mediated endocytosis in neurons."},{"id":"ENSMUSP00000029786","abundance":14.5,"rank":3377,"name":"Mrpl9","annotation":"39S ribosomal protein L9, mitochondrial; Belongs to the bacterial ribosomal protein bL9 family."},{"id":"ENSMUSP00000073701","abundance":14.5,"rank":3378,"name":"Mbd2","annotation":"Methyl-CpG-binding domain protein 2; Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity). May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity). Selectively represses transcription activity of methylated rRNA promoters."},{"id":"ENSMUSP00000079553","abundance":14.5,"rank":3379,"name":"Sgip1","annotation":"SH3-containing GRB2-like protein 3-interacting protein 1; May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis."},{"id":"ENSMUSP00000073974","abundance":14.5,"rank":3380,"name":"Axin1","annotation":"Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upo [...] "},{"id":"ENSMUSP00000138581","abundance":14.5,"rank":3381,"name":"Rpf2","annotation":"Ribosome production factor 2 homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus; Belongs to the RPF2 family."},{"id":"ENSMUSP00000141553","abundance":14.5,"rank":3382,"name":"Tnr","annotation":"Tenascin-R; Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repul [...] "},{"id":"ENSMUSP00000086114","abundance":14.5,"rank":3383,"name":"Grk2","annotation":"Beta-adrenergic receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner. Positively regulates ciliary smoothened (SMO)- dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Belongs to the protei [...] "},{"id":"ENSMUSP00000026986","abundance":14.5,"rank":3384,"name":"Higd2a","annotation":"HIG1 domain family member 2A; Proposed subunit of cytochrome c oxidase (COX, complex IV), which is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. May be involved in cytochrome c oxidase activity. May play a role in the assembly of respiratory supercomplexes (By similarity)."},{"id":"ENSMUSP00000099736","abundance":14.5,"rank":3385,"name":"H2-T3","annotation":"H-2 class I histocompatibility antigen, TLA(B) alpha chain; Involved in the presentation of foreign antigens to the immune system; Belongs to the MHC class I family."},{"id":"ENSMUSP00000026398","abundance":14.5,"rank":3386,"name":"Mettl7b","annotation":"Methyltransferase-like protein 7B; Probable methyltransferase."},{"id":"ENSMUSP00000142205","abundance":14.5,"rank":3387,"name":"Mme","annotation":"Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) (By similarity). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers."},{"id":"ENSMUSP00000021649","abundance":14.5,"rank":3388,"name":"Acot2","annotation":"Acyl-coenzyme A thioesterase 2, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 2/ACOT2 displays higher activity toward long chain acyl CoAs (C14-C20). The enzyme is involved in enhancing the hepatic fatty acid oxidation in mitochondria. Belongs to the C/M/P thioester hydrolase family."},{"id":"ENSMUSP00000020403","abundance":14.4,"rank":3389,"name":"Csrp2","annotation":"Cysteine and glycine-rich protein 2; Drastically down-regulated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vascular system (By similarity)."},{"id":"ENSMUSP00000108557","abundance":14.4,"rank":3390,"name":"Nmnat3","annotation":"Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleo [...] "},{"id":"ENSMUSP00000128546","abundance":14.4,"rank":3391,"name":"Rnf20","annotation":"E3 ubiquitin-protein ligase BRE1A; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradic [...] "},{"id":"ENSMUSP00000017090","abundance":14.4,"rank":3392,"name":"Kctd5","annotation":"BTB/POZ domain-containing protein KCTD5; Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (By similarity). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity)."},{"id":"ENSMUSP00000108012","abundance":14.4,"rank":3393,"name":"Pm20d1","annotation":"N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Bidirectional N-fatty-acyl amino acid synthase/hydrolase that regulates the production of N-fatty-acyl amino acids. These metabolites are endogenous chemical uncouplers of mitochondrial respiration. In an UCP1-independent manner, maybe through interaction with mitochondrial transporters, they promote proton leakage into the mitochondrial matrix. Thereby, this secreted protein may indirectly regulate the bodily dissipation of chemical energy as heat through thermogenic respiration."},{"id":"ENSMUSP00000020248","abundance":14.4,"rank":3394,"name":"Washc3","annotation":"WASH complex subunit 3; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting."},{"id":"ENSMUSP00000103817","abundance":14.4,"rank":3395,"name":"Dcun1d1","annotation":"DCN1-like protein 1; Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8 (UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity (By simila [...] "},{"id":"ENSMUSP00000109104","abundance":14.4,"rank":3396,"name":"Rasgrp2","annotation":"RAS guanyl-releasing protein 2; Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway."},{"id":"ENSMUSP00000023805","abundance":14.4,"rank":3397,"name":"Csad","annotation":"Cysteine sulfinic acid decarboxylase; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is 3- sulfino-L-alanine. Does not exhibit any decarboxylation activity toward glutamate."},{"id":"ENSMUSP00000019638","abundance":14.4,"rank":3398,"name":"Cops6","annotation":"COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with  [...] "},{"id":"ENSMUSP00000099002","abundance":14.4,"rank":3399,"name":"Serpinb9","annotation":"Serine (Or cysteine) peptidase inhibitor, clade B, member 9; Belongs to the serpin family."},{"id":"ENSMUSP00000046311","abundance":14.4,"rank":3400,"name":"Nenf","annotation":"Neudesin; Acts as a neurotrophic factor in postnatal mature neurons, enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocytes. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance."},{"id":"ENSMUSP00000100025","abundance":14.3,"rank":3401,"name":"Stam","annotation":"Signal transducing adapter molecule 1; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking process [...] "},{"id":"ENSMUSP00000152187","abundance":14.3,"rank":3402,"name":"Fam50b","annotation":"Protein FAM50B."},{"id":"ENSMUSP00000027615","abundance":14.3,"rank":3403,"name":"F13b","annotation":"Coagulation factor XIII B chain; The B chain of factor XIII is not catalytically active, but is thought to stabilize the A subunits and regulate the rate of transglutaminase formation by thrombin."},{"id":"ENSMUSP00000001825","abundance":14.3,"rank":3404,"name":"Chordc1","annotation":"Cysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2. Proposed to act as co-chaperone for HSP90. May play a role in the regulation of NOD1 via a HSP90 chaperone complex. In vitro, has intrinsic chaperone activity. This function may be achieved by inhibiting association of ROCK2 with NPM1. Involved in stress response. Prevents tumorigenesis (By similarity)."},{"id":"ENSMUSP00000056693","abundance":14.3,"rank":3405,"name":"Lamtor4","annotation":"Ragulator complex protein LAMTOR4, N-terminally processed; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity)."},{"id":"ENSMUSP00000019803","abundance":14.3,"rank":3406,"name":"Ccdc12","annotation":"Coiled-coil domain-containing protein 12."},{"id":"ENSMUSP00000023593","abundance":14.3,"rank":3407,"name":"Adipoq","annotation":"Adiponectin; Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis  [...] "},{"id":"ENSMUSP00000020851","abundance":14.3,"rank":3408,"name":"Cox11","annotation":"Cytochrome c oxidase assembly protein COX11, mitochondrial; Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I."},{"id":"ENSMUSP00000091318","abundance":14.3,"rank":3409,"name":"Plscr1","annotation":"Phospholipid scramblase 1; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system."},{"id":"ENSMUSP00000103086","abundance":14.3,"rank":3410,"name":"Dpm3","annotation":"Dolichol-phosphate mannosyltransferase subunit 3; Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit DPM1 to the ER. Belongs to the DPM3 family."},{"id":"ENSMUSP00000015892","abundance":14.2,"rank":3411,"name":"Prpf3","annotation":"U4/U6 small nuclear ribonucleoprotein Prp3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)."},{"id":"ENSMUSP00000031181","abundance":14.2,"rank":3412,"name":"Ugt2b34","annotation":"UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000023684","abundance":14.2,"rank":3413,"name":"Gart","annotation":"Trifunctional purine biosynthetic protein adenosine-3; In the N-terminal section; belongs to the GARS family.  In the C-terminal section; belongs to the GART family."},{"id":"ENSMUSP00000144572","abundance":14.2,"rank":3414,"name":"Pds5b","annotation":"Sister chromatid cohesion protein PDS5 homolog B; Regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Plays a role in androgen-induced proliferative arrest in prostate cells (By similarity)."},{"id":"ENSMUSP00000020497","abundance":14.2,"rank":3415,"name":"Aldh1l2","annotation":"Mitochondrial 10-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family."},{"id":"ENSMUSP00000037719","abundance":14.2,"rank":3416,"name":"Tgfbi","annotation":"Transforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion. May play a role in cell-collagen interactions (By similarity)."},{"id":"ENSMUSP00000028223","abundance":14.2,"rank":3417,"name":"Kynu","annotation":"Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity."},{"id":"ENSMUSP00000047898","abundance":14.2,"rank":3418,"name":"Ddx19a","annotation":"ATP-dependent RNA helicase DDX19A; ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (By similarity)."},{"id":"ENSMUSP00000018506","abundance":14.2,"rank":3419,"name":"Kpna2","annotation":"Importin subunit alpha-1; Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are [...] "},{"id":"ENSMUSP00000137310","abundance":14.2,"rank":3420,"name":"Gm10184","annotation":"Predicted pseudogene 10184."},{"id":"ENSMUSP00000084461","abundance":14.2,"rank":3421,"name":"Ppp1r10","annotation":"Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G)  [...] "},{"id":"ENSMUSP00000101517","abundance":14.2,"rank":3422,"name":"Arid1a","annotation":"AT-rich interactive domain-containing protein 1A; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural devel [...] "},{"id":"ENSMUSP00000078216","abundance":14.1,"rank":3423,"name":"Fggy","annotation":"FGGY carbohydrate kinase domain-containing protein."},{"id":"ENSMUSP00000107434","abundance":14.1,"rank":3424,"name":"Recql","annotation":"ATP-dependent DNA helicase Q1; Isoform alpha is a DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Isoform beta may have important roles in the meiotic process. Both isoforms exhibit a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction; Belongs to the helicase family. RecQ subfamily."},{"id":"ENSMUSP00000152773","abundance":14.1,"rank":3425,"name":"Tes3-ps","annotation":"DCN1-like protein."},{"id":"ENSMUSP00000040558","abundance":14.1,"rank":3426,"name":"Gm7030","annotation":"Predicted gene 7030; Belongs to the MHC class I family."},{"id":"ENSMUSP00000071868","abundance":14.1,"rank":3427,"name":"Mfap2","annotation":"Microfibrillar-associated protein 2; Component of the elastin-associated microfibrils."},{"id":"ENSMUSP00000110198","abundance":14.1,"rank":3428,"name":"Cetn2","annotation":"Centrin-2; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity).  The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, Xpa, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortio [...] "},{"id":"ENSMUSP00000023832","abundance":14.1,"rank":3429,"name":"Rgn","annotation":"Regucalcin; Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium- binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity); Belongs to the SMP-30/CGR1 family."},{"id":"ENSMUSP00000091659","abundance":14.1,"rank":3430,"name":"Cyp3a41a","annotation":"Cytochrome P450, family 3, subfamily a, polypeptide 41A."},{"id":"ENSMUSP00000075234","abundance":14.1,"rank":3431,"name":"Cyp3a41b","annotation":"Cytochrome P450 3A41."},{"id":"ENSMUSP00000104726","abundance":14.1,"rank":3432,"name":"0610009B22Rik","annotation":"RIKEN cDNA 0610009B22 gene."},{"id":"ENSMUSP00000112195","abundance":14.1,"rank":3433,"name":"Trappc2","annotation":"Trafficking protein particle complex subunit 2; Prevents ENO1-mediated transcriptional repression and antagonizes ENO1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi (By similarity)."},{"id":"ENSMUSP00000083250","abundance":14.1,"rank":3434,"name":"Ncor2","annotation":"Nuclear receptor corepressor 2; Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and and [...] "},{"id":"ENSMUSP00000031841","abundance":14.1,"rank":3435,"name":"Tra2a","annotation":"Transformer-2 protein homolog alpha; Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing; Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000036337","abundance":14.1,"rank":3436,"name":"Hdhd3","annotation":"Haloacid dehalogenase-like hydrolase domain-containing protein 3; Belongs to the HAD-like hydrolase superfamily."},{"id":"ENSMUSP00000010899","abundance":14.1,"rank":3437,"name":"Cars","annotation":"Cysteine--tRNA ligase, cytoplasmic."},{"id":"ENSMUSP00000153443","abundance":14.1,"rank":3438,"name":"Rmdn2","annotation":"Regulator of microtubule dynamics protein 2; Belongs to the RMDN family."},{"id":"ENSMUSP00000041300","abundance":14.1,"rank":3439,"name":"Ankrd6","annotation":"Ankyrin repeat domain-containing protein 6; Recruits CKI-epsilon to the beta-catenin degradation complex that consists of AXN1 or AXN2 and GSK3-beta and allows efficient phosphorylation of beta-catenin, thereby inhibiting beta-catenin/Tcf signals."},{"id":"ENSMUSP00000096254","abundance":14.1,"rank":3440,"name":"Cyp2a4","annotation":"Cytochrome P450 2A4; Highly active in the 15-alpha-hydroxylation of testosterone. Also active in the 15-alpha-hydroxylation of progesterone and androstenedione. Little or no activity on corticosterone, pregnenolone, dehydroepiandrosterone, estradiol or estriol; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000129378","abundance":14,"rank":3441,"name":"Csrp3","annotation":"Cysteine and glycine-rich protein 3; Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-li [...] "},{"id":"ENSMUSP00000042215","abundance":14,"rank":3442,"name":"Atp8a1","annotation":"Phospholipid-transporting ATPase IA; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS). The flippase complex ATP8A1:TMEM30A seems to play a role in r [...] "},{"id":"ENSMUSP00000003029","abundance":14,"rank":3443,"name":"Timm44","annotation":"Mitochondrial import inner membrane translocase subunit TIM44; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source."},{"id":"ENSMUSP00000105536","abundance":14,"rank":3444,"name":"Nf2","annotation":"Merlin; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF [...] "},{"id":"ENSMUSP00000110923","abundance":14,"rank":3445,"name":"Csf1r","annotation":"Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulat [...] "},{"id":"ENSMUSP00000021880","abundance":14,"rank":3446,"name":"Ctla2a","annotation":"Protein CTLA-2-alpha; Not known, expressed in activated T-cell; To the propeptide regions of cysteine proteases."},{"id":"ENSMUSP00000006963","abundance":14,"rank":3447,"name":"Krt28","annotation":"Keratin, type I cytoskeletal 28; Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs)."},{"id":"ENSMUSP00000032841","abundance":14,"rank":3448,"name":"Mrpl46","annotation":"39S ribosomal protein L46, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL46 family."},{"id":"ENSMUSP00000018992","abundance":14,"rank":3449,"name":"Rars","annotation":"Arginine--tRNA ligase, cytoplasmic; Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1."},{"id":"ENSMUSP00000020939","abundance":14,"rank":3450,"name":"Nrcam","annotation":"Neuronal cell adhesion molecule; Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by [...] "},{"id":"ENSMUSP00000070901","abundance":14,"rank":3451,"name":"Cib1","annotation":"Calcium and integrin-binding protein 1; Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin- mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulat [...] "},{"id":"ENSMUSP00000124017","abundance":13.9,"rank":3452,"name":"Fhit","annotation":"Bis(5'-adenosyl)-triphosphatase; Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosi [...] "},{"id":"ENSMUSP00000122582","abundance":13.9,"rank":3453,"name":"Hoxd11","annotation":"Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis."},{"id":"ENSMUSP00000104837","abundance":13.9,"rank":3454,"name":"Rnf114","annotation":"E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon produ [...] "},{"id":"ENSMUSP00000064515","abundance":13.9,"rank":3455,"name":"Usp39","annotation":"U4/U6.U5 tri-snRNP-associated protein 2; Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Does not have ubiquitin- specific peptidase activity."},{"id":"ENSMUSP00000107913","abundance":13.9,"rank":3456,"name":"Ap1s2","annotation":"AP-1 complex subunit sigma-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity)."},{"id":"ENSMUSP00000151642","abundance":13.9,"rank":3457,"name":"C1s2","annotation":"Complement C1s-B subcomponent heavy chain; C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity); Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000015585","abundance":13.9,"rank":3458,"name":"Gzmc","annotation":"Granzyme C; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily."},{"id":"ENSMUSP00000041820","abundance":13.9,"rank":3459,"name":"Cox15","annotation":"Cytochrome c oxidase assembly protein COX15 homolog; May be involved in the biosynthesis of heme A."},{"id":"ENSMUSP00000099768","abundance":13.9,"rank":3460,"name":"Cyp4b1","annotation":"Cytochrome P450 4B1; Responsible for mutagenic activation of 3-methoxy-4- aminoazobenzene (3-MeO-AAB); a potent procarcinogen. Also active on 2- aminofluorene and 2-aminoanthracene; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000050054","abundance":13.9,"rank":3461,"name":"Fhl4","annotation":"Four and a half LIM domains 4."},{"id":"ENSMUSP00000001485","abundance":13.9,"rank":3462,"name":"Mrpl10","annotation":"39S ribosomal protein L10, mitochondrial; Belongs to the universal ribosomal protein uL10 family."},{"id":"ENSMUSP00000066461","abundance":13.9,"rank":3463,"name":"Lgals4","annotation":"Galectin-4; Galectin that binds lactose and a related range of sugars."},{"id":"ENSMUSP00000149679","abundance":13.9,"rank":3464,"name":"Cck","annotation":"Cholecystokinin-12; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion; Belongs to the gastrin/cholecystokinin family."},{"id":"ENSMUSP00000099666","abundance":13.9,"rank":3465,"name":"Slc25a35","annotation":"Solute carrier family 25 member 35."},{"id":"ENSMUSP00000030775","abundance":13.8,"rank":3466,"name":"Chd5","annotation":"Chromodomain-helicase-DNA-binding protein 5; Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppr [...] "},{"id":"ENSMUSP00000025836","abundance":13.8,"rank":3467,"name":"Mrpl11","annotation":"39S ribosomal protein L11, mitochondrial; Belongs to the universal ribosomal protein uL11 family."},{"id":"ENSMUSP00000040900","abundance":13.8,"rank":3468,"name":"Nrn1","annotation":"Neuritin; Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and cortical cells."},{"id":"ENSMUSP00000058313","abundance":13.8,"rank":3469,"name":"Slc4a7","annotation":"Sodium bicarbonate cotransporter 3; Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity; Belongs to the anion exchanger (TC 2.A.31) family."},{"id":"ENSMUSP00000027338","abundance":13.8,"rank":3470,"name":"Sdhaf4","annotation":"Succinate dehydrogenase assembly factor 4, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Binds to the flavoprotein subunit Sdha in its FAD-bound form, blocking the generation of excess reactive oxigen species (ROS) and facilitating its assembly with the iron [...] "},{"id":"ENSMUSP00000072091","abundance":13.8,"rank":3471,"name":"Mink1","annotation":"Misshapen-like kinase 1; Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection [...] "},{"id":"ENSMUSP00000125880","abundance":13.8,"rank":3472,"name":"Mpp6","annotation":"MAGUK p55 subfamily member 6; Belongs to the MAGUK family."},{"id":"ENSMUSP00000022519","abundance":13.8,"rank":3473,"name":"Anxa8","annotation":"Annexin A8; This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade; Belongs to the annexin family."},{"id":"ENSMUSP00000051263","abundance":13.8,"rank":3474,"name":"Vps35l","annotation":"VPS35 endosomal protein sorting factor-like; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numero [...] "},{"id":"ENSMUSP00000130360","abundance":13.8,"rank":3475,"name":"Chid1","annotation":"Chitinase domain-containing protein 1; Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro) (By similarity); Belongs to the glycosyl hydrolase 18 family."},{"id":"ENSMUSP00000002048","abundance":13.8,"rank":3476,"name":"Taco1","annotation":"Translational activator of cytochrome c oxidase 1; Acts as a translational activator of mitochondrially-encoded cytochrome c oxidase 1; Belongs to the TACO1 family."},{"id":"ENSMUSP00000110685","abundance":13.8,"rank":3477,"name":"Tmub1","annotation":"Transmembrane and ubiquitin-like domain-containing protein 1; Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (By similarity). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as negative regulator of hepatocyte growth during regeneration (By similarity)."},{"id":"ENSMUSP00000157971","abundance":13.8,"rank":3478,"name":"Ubxn1","annotation":"UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibi [...] "},{"id":"ENSMUSP00000122896","abundance":13.7,"rank":3479,"name":"Dlgap1","annotation":"Disks large-associated protein 1; Part of the postsynaptic scaffold in neuronal cells; Belongs to the SAPAP family."},{"id":"ENSMUSP00000048836","abundance":13.7,"rank":3480,"name":"C1qa","annotation":"Complement C1q subcomponent subunit A; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes."},{"id":"ENSMUSP00000019683","abundance":13.7,"rank":3481,"name":"Rcn3","annotation":"Reticulocalbin-3; Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum. Required for the proper biosynthesis and transport of pulmonary surfactant- associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3. By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis. Has an anti-fibrotic activity by negatively regulating the secretion of type  [...] "},{"id":"ENSMUSP00000025161","abundance":13.7,"rank":3482,"name":"Tapbp","annotation":"Tapasin; Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)."},{"id":"ENSMUSP00000066806","abundance":13.7,"rank":3483,"name":"Ddx19b","annotation":"DEAD (Asp-Glu-Ala-Asp) box polypeptide 19b."},{"id":"ENSMUSP00000027464","abundance":13.7,"rank":3484,"name":"Mrpl44","annotation":"39S ribosomal protein L44, mitochondrial; Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome; Belongs to the ribonuclease III family. Mitochondrion- specific ribosomal protein mL44 subfamily."},{"id":"ENSMUSP00000027626","abundance":13.7,"rank":3485,"name":"Nifk","annotation":"MKI67 FHA domain-interacting nucleolar phosphoprotein."},{"id":"ENSMUSP00000072236","abundance":13.7,"rank":3486,"name":"Ugt3a2","annotation":"UDP-glucuronosyltransferase 3A2; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000002808","abundance":13.7,"rank":3487,"name":"Prkra","annotation":"Interferon-inducible double-stranded RNA-dependent protein kinase activator A; Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1 (By similarity). Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Promotes UBC9- p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhance [...] "},{"id":"ENSMUSP00000075683","abundance":13.7,"rank":3488,"name":"Pepd","annotation":"Xaa-Pro dipeptidase; Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because of the high level of iminoacids in collagen; Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily."},{"id":"ENSMUSP00000015578","abundance":13.7,"rank":3489,"name":"Gzmg","annotation":"Granzyme G; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily."},{"id":"ENSMUSP00000109371","abundance":13.7,"rank":3490,"name":"Gm11127","annotation":"Predicted gene 11127; Belongs to the MHC class I family."},{"id":"ENSMUSP00000028668","abundance":13.7,"rank":3491,"name":"Eif3j1","annotation":"Eukaryotic translation initiation factor 3 subunit J-A; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination rib [...] "},{"id":"ENSMUSP00000032835","abundance":13.7,"rank":3492,"name":"Acan","annotation":"Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage."},{"id":"ENSMUSP00000030795","abundance":13.6,"rank":3493,"name":"Abcf2","annotation":"ATP-binding cassette sub-family F member 2; Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily."},{"id":"ENSMUSP00000029780","abundance":13.6,"rank":3494,"name":"Ptbp2","annotation":"Polypyrimidine tract-binding protein 2; RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation."},{"id":"ENSMUSP00000124205","abundance":13.6,"rank":3495,"name":"Wtap","annotation":"Pre-mRNA-splicing regulator WTAP; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR. Required for accumulation of METTL3 and METTL14 to nuclear speckle (By similarity). Acts as a mRNA splicing regulator (By similarity). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability (By similarity). Impairs WT [...] "},{"id":"ENSMUSP00000078886","abundance":13.6,"rank":3496,"name":"Hspbp1","annotation":"Hsp70-binding protein 1; Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of target proteins (By similarity)."},{"id":"ENSMUSP00000060761","abundance":13.6,"rank":3497,"name":"H1f10","annotation":"H1 histone family, member X."},{"id":"ENSMUSP00000077811","abundance":13.6,"rank":3498,"name":"Casc4","annotation":"Protein CASC4; Belongs to the GOLM1/CASC4 family."},{"id":"ENSMUSP00000002925","abundance":13.6,"rank":3499,"name":"Timmdc1","annotation":"Complex I assembly factor TIMMDC1, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity)."},{"id":"ENSMUSP00000022213","abundance":13.6,"rank":3500,"name":"Thbs4","annotation":"Thrombospondin-4; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via it [...] "},{"id":"ENSMUSP00000050958","abundance":13.6,"rank":3501,"name":"Pyurf","annotation":"Protein preY, mitochondrial."},{"id":"ENSMUSP00000126821","abundance":13.6,"rank":3502,"name":"S100a14","annotation":"Protein S100-A14; Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium (By similarity)."},{"id":"ENSMUSP00000099896","abundance":13.6,"rank":3503,"name":"Cd3e","annotation":"T-cell surface glycoprotein CD3 epsilon chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation o [...] "},{"id":"ENSMUSP00000005714","abundance":13.6,"rank":3504,"name":"Ube2m","annotation":"NEDD8-conjugating enzyme Ubc12; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation (By similarity)."},{"id":"ENSMUSP00000053178","abundance":13.6,"rank":3505,"name":"Tcf21","annotation":"Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May be involved in the organogenesis of the spleen and heart and in cardiac and coronary artery development. May function in the development and sex differentiation of gonad via transcriptional regulation of AD4BP/SF-1."},{"id":"ENSMUSP00000023360","abundance":13.6,"rank":3506,"name":"Mpv17l","annotation":"Mpv17-like protein; Isoform 1 and isoform 3 participate in reactive oxygen species metabolism by up- or down-regulation of the genes of antioxidant enzymes; Belongs to the peroxisomal membrane protein PXMP2/4 family."},{"id":"ENSMUSP00000052592","abundance":13.6,"rank":3507,"name":"Gsto2","annotation":"Glutathione S-transferase omega-2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Belongs to the GST superfamily. Omega family."},{"id":"ENSMUSP00000041983","abundance":13.5,"rank":3508,"name":"Baat","annotation":"Bile acid-CoA:amino acid N-acyltransferase; Catalyzes the amidation of bile acids (BAs) with the amino acid taurine. Selective for taurine conjugation of cholyl CoA and only taurine-conjugated BAs are found in bile. Amidation of BAs in the liver with taurine prior to their excretion into bile is an important biochemical event in bile acid metabolism (By similarity). This conjugation (or amidation) plays several important biological roles in that it promotes the secretion of BAs and cholesterol into bile and increases the detergent properties of BAs in the intestine, which facilitates l [...] "},{"id":"ENSMUSP00000002172","abundance":13.5,"rank":3509,"name":"Acp2","annotation":"Lysosomal acid phosphatase."},{"id":"ENSMUSP00000021203","abundance":13.5,"rank":3510,"name":"Timm22","annotation":"Mitochondrial import inner membrane translocase subunit Tim22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). Belongs to the Tim17/Tim22/Tim23 family."},{"id":"ENSMUSP00000041008","abundance":13.5,"rank":3511,"name":"H2-Ab1","annotation":"H-2 class II histocompatibility antigen, A beta chain; Belongs to the MHC class II family."},{"id":"ENSMUSP00000035898","abundance":13.5,"rank":3512,"name":"Scamp5","annotation":"Secretory carrier-associated membrane protein 5; Required for the calcium-dependent exocytosis of signal sequence-containing cytokines such as CCL5. Probably acts in cooperation with the SNARE machinery (By similarity)."},{"id":"ENSMUSP00000123865","abundance":13.5,"rank":3513,"name":"Dcaf1","annotation":"DDB1- and CUL4-associated factor 1; Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine- protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin- protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds me [...] "},{"id":"ENSMUSP00000126980","abundance":13.5,"rank":3514,"name":"Dlgap4","annotation":"Disks large-associated protein 4; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane (By similarity); Belongs to the SAPAP family."},{"id":"ENSMUSP00000023538","abundance":13.5,"rank":3515,"name":"Mylk","annotation":"Myosin light chain kinase, smooth muscle, deglutamylated form; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessa [...] "},{"id":"ENSMUSP00000088833","abundance":13.5,"rank":3516,"name":"Prnp","annotation":"Major prion protein; Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase deg [...] "},{"id":"ENSMUSP00000051657","abundance":13.5,"rank":3517,"name":"Psmd8","annotation":"26S proteasome non-ATPase regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S14 family."},{"id":"ENSMUSP00000066990","abundance":13.5,"rank":3518,"name":"Mrps21","annotation":"28S ribosomal protein S21, mitochondrial; Belongs to the bacterial ribosomal protein bS21 family."},{"id":"ENSMUSP00000101514","abundance":13.5,"rank":3519,"name":"Rps6ka1","annotation":"Ribosomal protein S6 kinase alpha-1; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro- apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activa [...] "},{"id":"ENSMUSP00000020550","abundance":13.5,"rank":3520,"name":"Cdc34","annotation":"Ubiquitin-conjugating enzyme E2 R1; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination. Cooperates with the E2 UBCH5C and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Performs ubiquitin chain elongation building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. UBE2D3 acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Cooper [...] "},{"id":"ENSMUSP00000066701","abundance":13.5,"rank":3521,"name":"Mpz","annotation":"Myelin protein P0; Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. Belongs to the myelin P0 protein family."},{"id":"ENSMUSP00000074787","abundance":13.4,"rank":3522,"name":"Gria2","annotation":"Glutamate receptor 2; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of  [...] "},{"id":"ENSMUSP00000027082","abundance":13.4,"rank":3523,"name":"Crygf","annotation":"Gamma-crystallin F; Crystallins are the dominant structural components of the vertebrate eye lens; Belongs to the beta/gamma-crystallin family."},{"id":"ENSMUSP00000040089","abundance":13.4,"rank":3524,"name":"Twist1","annotation":"Twist-related protein 1; Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN w [...] "},{"id":"ENSMUSP00000017629","abundance":13.4,"rank":3525,"name":"Top2b","annotation":"DNA topoisomerase 2-beta; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks."},{"id":"ENSMUSP00000130414","abundance":13.4,"rank":3526,"name":"Slc38a3","annotation":"Sodium-coupled neutral amino acid transporter 3; Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission."},{"id":"ENSMUSP00000019517","abundance":13.4,"rank":3527,"name":"Cops3","annotation":"COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association [...] "},{"id":"ENSMUSP00000060912","abundance":13.4,"rank":3528,"name":"Gulo","annotation":"L-gulonolactone oxidase; Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L- xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. Belongs to the oxygen-dependent FAD-linked oxidoreductase family."},{"id":"ENSMUSP00000056655","abundance":13.4,"rank":3529,"name":"Sun1","annotation":"SUN domain-containing protein 1; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involv [...] "},{"id":"ENSMUSP00000104955","abundance":13.4,"rank":3530,"name":"Plxnb2","annotation":"Plexin-B2; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A- mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activ [...] "},{"id":"ENSMUSP00000030637","abundance":13.4,"rank":3531,"name":"Ncdn","annotation":"Neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth."},{"id":"ENSMUSP00000033822","abundance":13.4,"rank":3532,"name":"Proz","annotation":"Vitamin K-dependent protein Z; Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids (By similarity); Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000126137","abundance":13.4,"rank":3533,"name":"Lifr","annotation":"Leukemia inhibitory factor receptor; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells; Belongs to the type I cytokine receptor family. Type 2 subfamily."},{"id":"ENSMUSP00000146585","abundance":13.4,"rank":3534,"name":"Map6","annotation":"Microtubule-associated protein 6; Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization. ECO:0000250|UniProtKB:Q96JE9."},{"id":"ENSMUSP00000047855","abundance":13.4,"rank":3535,"name":"Mcee","annotation":"Methylmalonyl-CoA epimerase, mitochondrial; Belongs to the methylmalonyl-CoA epimerase family."},{"id":"ENSMUSP00000130660","abundance":13.4,"rank":3536,"name":"Gba","annotation":"Lysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation (By similarity). Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide [...] "},{"id":"ENSMUSP00000045480","abundance":13.4,"rank":3537,"name":"Dync1li2","annotation":"Cytoplasmic dynein 1 light intermediate chain 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity)."},{"id":"ENSMUSP00000074578","abundance":13.4,"rank":3538,"name":"Ntm","annotation":"Neurotrimin; Neural cell adhesion molecule; Belongs to the immunoglobulin superfamily. IgLON family."},{"id":"ENSMUSP00000052942","abundance":13.3,"rank":3539,"name":"Sugt1","annotation":"Protein SGT1 homolog; May play a role in ubiquitination and subsequent proteasomal degradation of target proteins."},{"id":"ENSMUSP00000067193","abundance":13.3,"rank":3540,"name":"Defb37","annotation":"Beta-defensin 37; Has antibacterial activity."},{"id":"ENSMUSP00000119535","abundance":13.3,"rank":3541,"name":"Mrps24","annotation":"28S ribosomal protein S24, mitochondrial; Belongs to the universal ribosomal protein uS3 family."},{"id":"ENSMUSP00000057115","abundance":13.3,"rank":3542,"name":"Ctxn1","annotation":"Cortexin-1; May mediate extracellular or intracellular signaling of cortical neurons during forebrain development; Belongs to the cortexin family."},{"id":"ENSMUSP00000034277","abundance":13.3,"rank":3543,"name":"Emc8","annotation":"ER membrane protein complex subunit 8; Belongs to the EMC8/EMC9 family."},{"id":"ENSMUSP00000021114","abundance":13.3,"rank":3544,"name":"Galk1","annotation":"Galactokinase; Major enzyme for galactose metabolism; Belongs to the GHMP kinase family. GalK subfamily."},{"id":"ENSMUSP00000105828","abundance":13.3,"rank":3545,"name":"Mavs","annotation":"Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF- kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state (By similarity). Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of def [...] "},{"id":"ENSMUSP00000071752","abundance":13.3,"rank":3546,"name":"Commd7","annotation":"COMM domain-containing protein 7; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity."},{"id":"ENSMUSP00000077984","abundance":13.3,"rank":3547,"name":"Kifc5b","annotation":"Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family."},{"id":"ENSMUSP00000004560","abundance":13.3,"rank":3548,"name":"Bid","annotation":"BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c."},{"id":"ENSMUSP00000065282","abundance":13.3,"rank":3549,"name":"Abhd10","annotation":"Mycophenolic acid acyl-glucuronide esterase, mitochondrial."},{"id":"ENSMUSP00000076041","abundance":13.3,"rank":3550,"name":"Defa21","annotation":"Alpha-defensin 21; May have microbicidal activities; Belongs to the alpha-defensin family."},{"id":"ENSMUSP00000096496","abundance":13.3,"rank":3551,"name":"Defa22","annotation":"Alpha-defensin 22."},{"id":"ENSMUSP00000027989","abundance":13.2,"rank":3552,"name":"Hsd17b7","annotation":"3-keto-steroid reductase; Responsible for the reduction of the keto group on the C-3 of sterols; Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily."},{"id":"ENSMUSP00000002979","abundance":13.2,"rank":3553,"name":"Lamb1","annotation":"Laminin subunit beta-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex (By similarity). It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons (By similarity). Radial glial cells play a c [...] "},{"id":"ENSMUSP00000070728","abundance":13.2,"rank":3554,"name":"Btrc","annotation":"F-box/WD repeat-containing protein 1A; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (By similarity). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; [...] "},{"id":"ENSMUSP00000109630","abundance":13.2,"rank":3555,"name":"Ppp6r3","annotation":"Serine/threonine-protein phosphatase 6 regulatory subunit 3; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. May have an important role in maintaining immune self-tolerance (By similarity)."},{"id":"ENSMUSP00000029038","abundance":13.2,"rank":3556,"name":"Fabp9","annotation":"Fatty acid-binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family."},{"id":"ENSMUSP00000024734","abundance":13.2,"rank":3557,"name":"Mrpl14","annotation":"39S ribosomal protein L14, mitochondrial; May form part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1, intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation."},{"id":"ENSMUSP00000036093","abundance":13.2,"rank":3558,"name":"Ipo9","annotation":"Importin-9; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] "},{"id":"ENSMUSP00000028117","abundance":13.1,"rank":3559,"name":"Yme1l1","annotation":"ATP-dependent zinc metalloprotease YME1L1; ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (By similarity). Plays an important role in regulating mitochondrial morphology and function by cleaving OPA1 at position S2, giving rise to a form of OPA1 that promotes maintenance of normal mitochondrial structure. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from th [...] "},{"id":"ENSMUSP00000066859","abundance":13.1,"rank":3560,"name":"Isoc2b","annotation":"Isochorismatase domain-containing protein 2B."},{"id":"ENSMUSP00000132922","abundance":13.1,"rank":3561,"name":"Ergic1","annotation":"Endoplasmic reticulum-Golgi intermediate compartment protein 1; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family."},{"id":"ENSMUSP00000017332","abundance":13.1,"rank":3562,"name":"Coa3","annotation":"Cytochrome c oxidase assembly factor 3 homolog, mitochondrial; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for efficient translation of MT-CO1 and mitochondrial respiratory chain complex IV assembly."},{"id":"ENSMUSP00000029850","abundance":13.1,"rank":3563,"name":"Cryz","annotation":"Quinone oxidoreductase; Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity)."},{"id":"ENSMUSP00000024707","abundance":13.1,"rank":3564,"name":"Mep1a","annotation":"Meprin A subunit alpha."},{"id":"ENSMUSP00000027975","abundance":13.1,"rank":3565,"name":"Phyh","annotation":"Phytanoyl-CoA dioxygenase, peroxisomal; Converts phytanoyl-CoA to 2-hydroxyphytanoyl-CoA."},{"id":"ENSMUSP00000008280","abundance":13.1,"rank":3566,"name":"Fhl2","annotation":"Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes."},{"id":"ENSMUSP00000004959","abundance":13.1,"rank":3567,"name":"Grap","annotation":"GRB2-related adapter protein; Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing; Belongs to the GRB2/sem-5/DRK family."},{"id":"ENSMUSP00000045111","abundance":13.1,"rank":3568,"name":"Mrps34","annotation":"28S ribosomal protein S34, mitochondrial; Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation. Belongs to the mitochondrion-specific ribosomal protein mS34 family."},{"id":"ENSMUSP00000046639","abundance":13.1,"rank":3569,"name":"Pdpr","annotation":"Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial; Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine."},{"id":"ENSMUSP00000061923","abundance":13.1,"rank":3570,"name":"Mcm2","annotation":"DNA replication licensing factor MCM2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] "},{"id":"ENSMUSP00000004965","abundance":13.1,"rank":3571,"name":"Chmp2b","annotation":"Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] "},{"id":"ENSMUSP00000032183","abundance":13.1,"rank":3572,"name":"Tmem43","annotation":"Transmembrane protein 43; May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane."},{"id":"ENSMUSP00000017443","abundance":13.1,"rank":3573,"name":"Dnttip1","annotation":"Deoxynucleotidyltransferase terminal-interacting protein 1; Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA."},{"id":"ENSMUSP00000021083","abundance":13.1,"rank":3574,"name":"Jpt1","annotation":"Jupiter microtubule associated homolog 1, N-terminally processed; Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (By similarity). Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation (By similarity)."},{"id":"ENSMUSP00000023572","abundance":13.1,"rank":3575,"name":"Cxadr","annotation":"Coxsackievirus and adenovirus receptor homolog; Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induc [...] "},{"id":"ENSMUSP00000042183","abundance":13.1,"rank":3576,"name":"Ttc36","annotation":"Tetratricopeptide repeat protein 36; Belongs to the TTC36 family."},{"id":"ENSMUSP00000106336","abundance":13.1,"rank":3577,"name":"Srp54b","annotation":"Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)."},{"id":"ENSMUSP00000152764","abundance":13.1,"rank":3578,"name":"Srp54a","annotation":"Signal recognition particle 54A."},{"id":"ENSMUSP00000042727","abundance":13,"rank":3579,"name":"Zc3h10","annotation":"Zinc finger CCCH domain-containing protein 10; Specific regulator of miRNA biogenesis. Binds, via the C3H1- type zinc finger domains, to the binding motif 5'-GCAGCGC-3' on microRNA pri-MIR143 and negatively regulates the processing to mature microRNA."},{"id":"ENSMUSP00000116252","abundance":13,"rank":3580,"name":"Grwd1","annotation":"Glutamate-rich WD repeat-containing protein 1; Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness."},{"id":"ENSMUSP00000023531","abundance":13,"rank":3581,"name":"Hcls1","annotation":"Hematopoietic lineage cell-specific protein; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression (By similarity)."},{"id":"ENSMUSP00000002403","abundance":13,"rank":3582,"name":"Dhrs1","annotation":"Dehydrogenase/reductase SDR family member 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000126464","abundance":13,"rank":3583,"name":"Acox2","annotation":"Peroxisomal acyl-coenzyme A oxidase 2; Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycoprostanic acids (By similarity). Capable of oxidizing short as well as long chain 2-methyl branched fatty acids (By similarity)."},{"id":"ENSMUSP00000068374","abundance":13,"rank":3584,"name":"Map1b","annotation":"Microtubule-associated protein 1B; Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1- mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation."},{"id":"ENSMUSP00000022063","abundance":13,"rank":3585,"name":"Ccdc127","annotation":"Coiled-coil domain-containing protein 127."},{"id":"ENSMUSP00000001127","abundance":13,"rank":3586,"name":"Poldip2","annotation":"Polymerase delta-interacting protein 2; Involved in DNA damage tolerance by regulating translesion synthesis (TLS) of templates carrying DNA damage lesions such as 8oxoG and abasic sites. May act by stimulating activity of DNA polymerases involved in TLS, such as PRIMPOL and polymerase delta (POLD1)."},{"id":"ENSMUSP00000043909","abundance":13,"rank":3587,"name":"Nfya","annotation":"Nuclear transcription factor Y subunit alpha; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. NF-YA positively regulates the transcription of the core clock component ARNTL/BMAL1."},{"id":"ENSMUSP00000075290","abundance":13,"rank":3588,"name":"Tsnax","annotation":"Translin-associated protein X; Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity); Belongs to the translin family."},{"id":"ENSMUSP00000047480","abundance":13,"rank":3589,"name":"Kcnab1","annotation":"Voltage-gated potassium channel subunit beta-1; Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Modulates action potentials via its effect on the pore-forming alpha subunits. Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases channel activity. Mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (By similarity). Promotes the closure of KCNA1, KC [...] "},{"id":"ENSMUSP00000156607","abundance":13,"rank":3590,"name":"Memo1","annotation":"Protein MEMO1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity)."},{"id":"ENSMUSP00000113465","abundance":13,"rank":3591,"name":"Dpf2","annotation":"Zinc finger protein ubi-d4; Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells (By similarity). Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF- kappa-B pathway (By similarity)."},{"id":"ENSMUSP00000122863","abundance":13,"rank":3592,"name":"Mfap5","annotation":"Microfibrillar-associated protein 5; May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity. Component of the elastin-associated microfibrils (By similarity)."},{"id":"ENSMUSP00000027475","abundance":13,"rank":3593,"name":"Gigyf2","annotation":"GRB10-interacting GYF protein 2; Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay. May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors ; Belongs to the GIGYF family."},{"id":"ENSMUSP00000047894","abundance":13,"rank":3594,"name":"Inhba","annotation":"Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000076964","abundance":13,"rank":3595,"name":"Zfp1","annotation":"Zinc finger protein 1; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000031773","abundance":12.9,"rank":3596,"name":"Pon3","annotation":"Serum paraoxonase/lactonase 3; Has low activity towards the organophosphate paraxon and aromatic carboxylic acid esters. Rapidly hydrolyzes lactones such as statin prodrugs (e.g. lovastatin). Hydrolyzes aromatic lactones and 5- or 6-member ring lactones with aliphatic substituents but not simple lactones or those with polar substituents (By similarity)."},{"id":"ENSMUSP00000022757","abundance":12.9,"rank":3597,"name":"Gzmf","annotation":"Granzyme F; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily."},{"id":"ENSMUSP00000019199","abundance":12.9,"rank":3598,"name":"Plod1","annotation":"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Forms hydroxylysine residues in -Xaa-Lys- Gly- sequences in collagens (By similarity). These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links."},{"id":"ENSMUSP00000023550","abundance":12.9,"rank":3599,"name":"Pdia5","annotation":"Protein disulfide-isomerase A5."},{"id":"ENSMUSP00000139372","abundance":12.9,"rank":3600,"name":"Hnrnpll","annotation":"Heterogeneous nuclear ribonucleoprotein L-like; RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC."},{"id":"ENSMUSP00000080614","abundance":12.9,"rank":3601,"name":"Timm50","annotation":"Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Has some phosphatase activity in vitro; however such activity may not be relevant in vivo."},{"id":"ENSMUSP00000088458","abundance":12.9,"rank":3602,"name":"Ermn","annotation":"Ermin; Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity)."},{"id":"ENSMUSP00000034524","abundance":12.9,"rank":3603,"name":"Rexo2","annotation":"Oligoribonuclease, mitochondrial; 3'-to-5' exoribonuclease specific for small oligoribonucleotides. Active on small (primarily </=5 nucleotides in length) single-stranded RNA and DNA oligomers. May have a role for cellular nucleotide recycling (By similarity); Belongs to the oligoribonuclease family."},{"id":"ENSMUSP00000029147","abundance":12.9,"rank":3604,"name":"Nfs1","annotation":"Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters. May be involved in the biosynthesis of molybdenum cofactor (By similarity); Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily."},{"id":"ENSMUSP00000081912","abundance":12.9,"rank":3605,"name":"Numa1","annotation":"Nuclear mitotic apparatus protein 1; Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division. Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles. Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner. In metaphase, part of a ternary complex composed of GPSM2 and G(i) a [...] "},{"id":"ENSMUSP00000033489","abundance":12.9,"rank":3606,"name":"Praf2","annotation":"PRA1 family protein 2; May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptotic role in cerulenin-induced neuroblastoma apoptosis (By similarity)."},{"id":"ENSMUSP00000020311","abundance":12.9,"rank":3607,"name":"Micu1","annotation":"Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (By similarity). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (By similarity). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium sig [...] "},{"id":"ENSMUSP00000142900","abundance":12.9,"rank":3608,"name":"Grin2a","annotation":"Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...] "},{"id":"ENSMUSP00000091463","abundance":12.8,"rank":3609,"name":"Fzd2","annotation":"Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] "},{"id":"ENSMUSP00000100026","abundance":12.8,"rank":3610,"name":"Cntfr","annotation":"Ciliary neurotrophic factor receptor subunit alpha; Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity); Belongs to the type I cytokine receptor family. Type 3 subfamily."},{"id":"ENSMUSP00000029464","abundance":12.8,"rank":3611,"name":"Hao2","annotation":"Hydroxyacid oxidase 2; Has 2-hydroxyacid oxidase activity. Most active on medium- chain substrates; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family."},{"id":"ENSMUSP00000042860","abundance":12.8,"rank":3612,"name":"Gnpnat1","annotation":"Glucosamine 6-phosphate N-acetyltransferase; Belongs to the acetyltransferase family. GNA1 subfamily."},{"id":"ENSMUSP00000105680","abundance":12.8,"rank":3613,"name":"Use1","annotation":"Vesicle transport protein USE1; SNARE that may be involved in targeting and fusion of Golgi- derived retrograde transport vesicles with the ER; Belongs to the USE1 family."},{"id":"ENSMUSP00000111240","abundance":12.8,"rank":3614,"name":"Sgce","annotation":"Epsilon-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix."},{"id":"ENSMUSP00000034874","abundance":12.8,"rank":3615,"name":"Cyp11a1","annotation":"Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] "},{"id":"ENSMUSP00000139186","abundance":12.8,"rank":3616,"name":"Gm12117","annotation":"Predicted gene 12117."},{"id":"ENSMUSP00000092888","abundance":12.8,"rank":3617,"name":"Rpl7l1","annotation":"60S ribosomal protein L7-like 1; Belongs to the universal ribosomal protein uL30 family."},{"id":"ENSMUSP00000120830","abundance":12.8,"rank":3618,"name":"Strn","annotation":"Striatin; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family."},{"id":"ENSMUSP00000071078","abundance":12.7,"rank":3619,"name":"Cope","annotation":"Coatomer subunit epsilon; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex  [...] "},{"id":"ENSMUSP00000021048","abundance":12.7,"rank":3620,"name":"Ftsj3","annotation":"pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation."},{"id":"ENSMUSP00000139031","abundance":12.7,"rank":3621,"name":"Erc1","annotation":"ELKS/Rab6-interacting/CAST family member 1; Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport."},{"id":"ENSMUSP00000028921","abundance":12.7,"rank":3622,"name":"Xrn2","annotation":"5'-3' exoribonuclease 2; Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (By similarity); Belongs to th [...] "},{"id":"ENSMUSP00000041543","abundance":12.7,"rank":3623,"name":"Faah","annotation":"Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family."},{"id":"ENSMUSP00000079689","abundance":12.7,"rank":3624,"name":"Dab2","annotation":"Disabled homolog 2; Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2  [...] "},{"id":"ENSMUSP00000148069","abundance":12.7,"rank":3625,"name":"Aldh16a1","annotation":"Aldehyde dehydrogenase family 16 member A1."},{"id":"ENSMUSP00000095792","abundance":12.7,"rank":3626,"name":"Rragd","annotation":"Ras-related GTP-binding protein D; Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids (By similarity)."},{"id":"ENSMUSP00000099652","abundance":12.7,"rank":3627,"name":"Tjp1","annotation":"Tight junction protein ZO-1; Tjp1, TjpP2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity [...] "},{"id":"ENSMUSP00000004330","abundance":12.7,"rank":3628,"name":"Ikbkg","annotation":"NF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. Also considered to be a mediator for TAX activation of NF- kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires [...] "},{"id":"ENSMUSP00000109426","abundance":12.7,"rank":3629,"name":"Gm49948","annotation":"Predicted gene, 49948."},{"id":"ENSMUSP00000075098","abundance":12.7,"rank":3630,"name":"Methig1","annotation":"HIG1 domain family member 1C."},{"id":"ENSMUSP00000015941","abundance":12.7,"rank":3631,"name":"Bhmt2","annotation":"S-methylmethionine--homocysteine S-methyltransferase BHMT2; Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor."},{"id":"ENSMUSP00000033824","abundance":12.7,"rank":3632,"name":"Lamp1","annotation":"Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis."},{"id":"ENSMUSP00000099770","abundance":12.7,"rank":3633,"name":"Abcb11","annotation":"Bile salt export pump; Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine- conjugated bile salts."},{"id":"ENSMUSP00000147425","abundance":12.7,"rank":3634,"name":"Ins2","annotation":"Insulin-2 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver."},{"id":"ENSMUSP00000096555","abundance":12.7,"rank":3635,"name":"Bglap2","annotation":"Osteocalcin-2; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium; Belongs to the osteocalcin/matrix Gla protein family."},{"id":"ENSMUSP00000075425","abundance":12.7,"rank":3636,"name":"Bglap","annotation":"Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium; Belongs to the osteocalcin/matrix Gla protein family."},{"id":"ENSMUSP00000021958","abundance":12.6,"rank":3637,"name":"Pcbd2","annotation":"Pterin-4-alpha-carbinolamine dehydratase 2; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity); Belongs to the pterin-4-alpha-carbinolamine dehydratase family."},{"id":"ENSMUSP00000037514","abundance":12.6,"rank":3638,"name":"Tiprl","annotation":"TIP41-like protein; May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma- H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and rep [...] "},{"id":"ENSMUSP00000031117","abundance":12.6,"rank":3639,"name":"Gnpda2","annotation":"Glucosamine-6-phosphate isomerase 2; Belongs to the glucosamine/galactosamine-6-phosphate isomerase family."},{"id":"ENSMUSP00000109635","abundance":12.6,"rank":3640,"name":"Itsn1","annotation":"Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] "},{"id":"ENSMUSP00000022576","abundance":12.6,"rank":3641,"name":"Cpb2","annotation":"Carboxypeptidase B2; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin; Belongs to the peptidase M14 family."},{"id":"ENSMUSP00000030905","abundance":12.6,"rank":3642,"name":"Ssu72","annotation":"RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK; Belongs to the SSU72 phosphatase family."},{"id":"ENSMUSP00000025764","abundance":12.6,"rank":3643,"name":"Cst6","annotation":"Cystatin E/M."},{"id":"ENSMUSP00000112998","abundance":12.6,"rank":3644,"name":"Rasa3","annotation":"Ras GTPase-activating protein 3; Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4)."},{"id":"ENSMUSP00000131584","abundance":12.6,"rank":3645,"name":"Cox7a2l","annotation":"Cytochrome c oxidase subunit 7A-related protein, mitochondrial; Involved in the regulation of oxidative phosphorylation and energy metabolism. Necessary for the assembly of mitochondrial respiratory supercomplex."},{"id":"ENSMUSP00000025797","abundance":12.6,"rank":3646,"name":"Mbl2","annotation":"Mannose-binding protein C; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity)."},{"id":"ENSMUSP00000077971","abundance":12.6,"rank":3647,"name":"Phf6","annotation":"PHD finger protein 6; Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription."},{"id":"ENSMUSP00000029748","abundance":12.6,"rank":3648,"name":"Fcgr1","annotation":"High affinity immunoglobulin gamma Fc receptor I; High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses."},{"id":"ENSMUSP00000005057","abundance":12.6,"rank":3649,"name":"Thop1","annotation":"Thimet oligopeptidase; Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity)."},{"id":"ENSMUSP00000158533","abundance":12.6,"rank":3650,"name":"H2-Eb1","annotation":"H-2 class II histocompatibility antigen, E-B beta chain; Belongs to the MHC class II family."},{"id":"ENSMUSP00000090061","abundance":12.6,"rank":3651,"name":"2610028H24Rik","annotation":"RIKEN cDNA 2610028H24 gene."},{"id":"ENSMUSP00000048111","abundance":12.6,"rank":3652,"name":"Spr","annotation":"Sepiapterin reductase; Catalyzes the final one or two reductions in tetra- hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin."},{"id":"ENSMUSP00000069284","abundance":12.6,"rank":3653,"name":"Pi4k2a","annotation":"Phosphatidylinositol 4-kinase type 2-alpha; Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4- phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second mess [...] "},{"id":"ENSMUSP00000107292","abundance":12.5,"rank":3654,"name":"Fgfr1op2","annotation":"FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway."},{"id":"ENSMUSP00000021853","abundance":12.5,"rank":3655,"name":"Eci3","annotation":"Enoyl-CoA delta isomerase 3, peroxisomal; Catalyzes the isomerization of trans-3-nonenoyl-CoA into trans-2-nonenoyl-CoA. May also have activity towards other enoyl-CoA species (Probable)."},{"id":"ENSMUSP00000112683","abundance":12.5,"rank":3656,"name":"Bdh2","annotation":"3-hydroxybutyrate dehydrogenase type 2; Dehydrogenase that mediates the formation of 2,5- dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria. Also acts as a 3- hydroxybutyrate dehydrogenase (By similarity)."},{"id":"ENSMUSP00000105732","abundance":12.5,"rank":3657,"name":"Zc3h14","annotation":"Zinc finger CCCH domain-containing protein 14; Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides."},{"id":"ENSMUSP00000036881","abundance":12.5,"rank":3658,"name":"Abcf1","annotation":"ATP-binding cassette sub-family F member 1; Required for efficient Cap- and IRES-mediated mRNA translation initiation. Not involved in the ribosome biogenesis (By similarity); Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily."},{"id":"ENSMUSP00000086978","abundance":12.5,"rank":3659,"name":"Gzme","annotation":"Granzyme E; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily."},{"id":"ENSMUSP00000022053","abundance":12.5,"rank":3660,"name":"Trip13","annotation":"Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher- order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...] "},{"id":"ENSMUSP00000021522","abundance":12.5,"rank":3661,"name":"Glrx5","annotation":"Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters (By similarity). Involved in protein lipoylation, acting in the pathway that provides an iron-sulfur cluster to lipoate synthase (By similarity). Required for normal iron homeostasis (By similarity). Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1 (By similarity). May protect cells against apoptosis due to reactive oxygen species and oxidative stress."},{"id":"ENSMUSP00000044280","abundance":12.5,"rank":3662,"name":"Pcyt1b","annotation":"Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis. Belongs to the cytidylyltransferase family."},{"id":"ENSMUSP00000034830","abundance":12.5,"rank":3663,"name":"Crabp1","annotation":"Cellular retinoic acid-binding protein 1; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors."},{"id":"ENSMUSP00000108929","abundance":12.5,"rank":3664,"name":"Srpx2","annotation":"Sushi repeat-containing protein SRPX2; Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations."},{"id":"ENSMUSP00000086923","abundance":12.5,"rank":3665,"name":"Isy1","annotation":"Pre-mRNA-splicing factor ISY1 homolog; Component of the spliceosome C complex required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation. Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a. Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively. Required during the transition of embryonic stem cells (ESCs) from the naive to primed state. By enhancing miRNA biogenesis, promotes exit of ESCs from the naive state to an in [...] "},{"id":"ENSMUSP00000109121","abundance":12.5,"rank":3666,"name":"Exoc1","annotation":"Exocyst complex component 1; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane."},{"id":"ENSMUSP00000105628","abundance":12.5,"rank":3667,"name":"Ddx24","annotation":"ATP-dependent RNA helicase DDX24; ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily."},{"id":"ENSMUSP00000060774","abundance":12.5,"rank":3668,"name":"Pdha2","annotation":"Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle."},{"id":"ENSMUSP00000093090","abundance":12.4,"rank":3669,"name":"Syne3","annotation":"Nesprin-3; As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is re [...] "},{"id":"ENSMUSP00000102408","abundance":12.4,"rank":3670,"name":"Pecam1","annotation":"Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (By similarity). Tyr-679 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (By similarity). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (By similarity). Heterophilic interaction with CD177 pla [...] "},{"id":"ENSMUSP00000039951","abundance":12.4,"rank":3671,"name":"Mrpl54","annotation":"39S ribosomal protein L54, mitochondrial."},{"id":"ENSMUSP00000005810","abundance":12.4,"rank":3672,"name":"Mthfd2","annotation":"Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency."},{"id":"ENSMUSP00000002133","abundance":12.4,"rank":3673,"name":"Sdf2","annotation":"Stromal cell-derived factor 2."},{"id":"ENSMUSP00000023759","abundance":12.4,"rank":3674,"name":"Smarcd1","annotation":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (n [...] "},{"id":"ENSMUSP00000034973","abundance":12.4,"rank":3675,"name":"Smad3","annotation":"Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] "},{"id":"ENSMUSP00000147164","abundance":12.4,"rank":3676,"name":"Supt5","annotation":"Transcription elongation factor SPT5; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote paus [...] "},{"id":"ENSMUSP00000002274","abundance":12.4,"rank":3677,"name":"Napsa","annotation":"Napsin-A; May be involved in processing of pneumocyte surfactant precursors."},{"id":"ENSMUSP00000019723","abundance":12.4,"rank":3678,"name":"Mydgf","annotation":"Myeloid-derived growth factor; Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway."},{"id":"ENSMUSP00000043066","abundance":12.3,"rank":3679,"name":"Hs2st1","annotation":"Heparan sulfate 2-O-sulfotransferase 1; Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high-affinity ligand- binding interactions and signaling processes. Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues [...] "},{"id":"ENSMUSP00000061991","abundance":12.3,"rank":3680,"name":"Phka1","annotation":"Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin."},{"id":"ENSMUSP00000018337","abundance":12.3,"rank":3681,"name":"Cdc73","annotation":"Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional [...] "},{"id":"ENSMUSP00000007251","abundance":12.3,"rank":3682,"name":"Abhd16a","annotation":"Phosphatidylserine lipase ABHD16A; Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes. Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z- octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)- prostaglandin J2 (15d-PGJ(2)-G). Belongs to the AB hydrolase superfamily. ABHD16  [...] "},{"id":"ENSMUSP00000106317","abundance":12.3,"rank":3683,"name":"C7","annotation":"Complement component 7."},{"id":"ENSMUSP00000028080","abundance":12.3,"rank":3684,"name":"Nebl","annotation":"LIM zinc-binding domain-containing Nebulette; Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion (By similarity)."},{"id":"ENSMUSP00000026405","abundance":12.3,"rank":3685,"name":"Bloc1s1","annotation":"Biogenesis of lysosome-related organelles complex 1 subunit 1; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movemen [...] "},{"id":"ENSMUSP00000080579","abundance":12.3,"rank":3686,"name":"Dysf","annotation":"Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Belongs to the ferlin family."},{"id":"ENSMUSP00000055455","abundance":12.3,"rank":3687,"name":"Cpox","annotation":"Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX (By similarity)."},{"id":"ENSMUSP00000082017","abundance":12.3,"rank":3688,"name":"Mark3","annotation":"MAP/microtubule affinity-regulating kinase 3; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAPT/TAU, MAP2 and MAP4. Phosphorylates CDC25C. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Belongs to the prote [...] "},{"id":"ENSMUSP00000105905","abundance":12.3,"rank":3689,"name":"Coq6","annotation":"Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6."},{"id":"ENSMUSP00000134572","abundance":12.3,"rank":3690,"name":"Kifc1","annotation":"Kinesin-like protein KIFC1; Minus end-directed microtubule-dependent motor required for bipolar spindle formation. May contribute to movement of early endocytic vesicles. Regulates cilium formation and structure. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. NCD subfamily."},{"id":"ENSMUSP00000108090","abundance":12.3,"rank":3691,"name":"Map7d2","annotation":"MAP7 domain-containing protein 2."},{"id":"ENSMUSP00000055694","abundance":12.3,"rank":3692,"name":"Cavin2","annotation":"Caveolae-associated protein 2; Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity)."},{"id":"ENSMUSP00000030986","abundance":12.2,"rank":3693,"name":"Lrpap1","annotation":"Alpha-2-macroglobulin receptor-associated protein; Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway."},{"id":"ENSMUSP00000020359","abundance":12.2,"rank":3694,"name":"Gamt","annotation":"Guanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Important in nervous system development."},{"id":"ENSMUSP00000020004","abundance":12.2,"rank":3695,"name":"Asf1a","annotation":"Histone chaperone ASF1A; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. Belongs to the ASF1 family."},{"id":"ENSMUSP00000086948","abundance":12.2,"rank":3696,"name":"Aak1","annotation":"AP2-associated protein kinase 1; Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization, promoting NUMB localization to endosomes. Binds to [...] "},{"id":"ENSMUSP00000106152","abundance":12.2,"rank":3697,"name":"C1qtnf3","annotation":"Complement C1q tumor necrosis factor-related protein 3."},{"id":"ENSMUSP00000068195","abundance":12.2,"rank":3698,"name":"Rab31","annotation":"Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] "},{"id":"ENSMUSP00000128772","abundance":12.2,"rank":3699,"name":"B930094E09Rik","annotation":"RIKEN cDNA B930094E09 gene."},{"id":"ENSMUSP00000052544","abundance":12.2,"rank":3700,"name":"Zadh2","annotation":"Prostaglandin reductase-3; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation."},{"id":"ENSMUSP00000002095","abundance":12.2,"rank":3701,"name":"Kmt2a","annotation":"Histone-lysine N-methyltransferase 2A; Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys- 4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no [...] "},{"id":"ENSMUSP00000040840","abundance":12.2,"rank":3702,"name":"Apmap","annotation":"Adipocyte plasma membrane-associated protein; Exhibits strong arylesterase activity with beta-naphthyl acetate and phenyl acetate (By similarity). May play a role in adipocyte differentiation."},{"id":"ENSMUSP00000126024","abundance":12.2,"rank":3703,"name":"Cdk6","annotation":"Cyclin-dependent kinase 6; Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cel [...] "},{"id":"ENSMUSP00000033289","abundance":12.2,"rank":3704,"name":"Stim1","annotation":"Stromal interaction molecule 1; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release- activated Ca(2+) (CRAC) channel subunit ORAI1. Involved in enamel formation. Activated following interaction with STIMATE, leading to promote STIM1 conformational switch."},{"id":"ENSMUSP00000023043","abundance":12.2,"rank":3705,"name":"Adsl","annotation":"Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily."},{"id":"ENSMUSP00000030814","abundance":12.2,"rank":3706,"name":"Cdk5","annotation":"Cyclin-dependent-like kinase 5; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neu [...] "},{"id":"ENSMUSP00000113770","abundance":12.2,"rank":3707,"name":"Zfp740","annotation":"Zinc finger protein 740; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000020756","abundance":12.1,"rank":3708,"name":"Pnpt1","annotation":"Polyribonucleotide nucleotidyltransferase 1, mitochondrial; RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By simi [...] "},{"id":"ENSMUSP00000034187","abundance":12.1,"rank":3709,"name":"Mmp2","annotation":"72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] "},{"id":"ENSMUSP00000034698","abundance":12.1,"rank":3710,"name":"Tmed1","annotation":"Transmembrane emp24 domain-containing protein 1; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side."},{"id":"ENSMUSP00000038063","abundance":12.1,"rank":3711,"name":"Dhcr24","annotation":"Delta(24)-sterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis (By similarity)."},{"id":"ENSMUSP00000108455","abundance":12.1,"rank":3712,"name":"Amot","annotation":"Angiomotin; Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions (By similarity)."},{"id":"ENSMUSP00000098617","abundance":12.1,"rank":3713,"name":"Prr27","annotation":"4930432K09Rik protein."},{"id":"ENSMUSP00000151681","abundance":12.1,"rank":3714,"name":"Srp54c","annotation":"Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily."},{"id":"ENSMUSP00000037631","abundance":12.1,"rank":3715,"name":"Mrps6","annotation":"28S ribosomal protein S6, mitochondrial; Belongs to the bacterial ribosomal protein bS6 family."},{"id":"ENSMUSP00000085467","abundance":12.1,"rank":3716,"name":"Mettl7a2","annotation":"Methyltransferase-like 7A2."},{"id":"ENSMUSP00000083204","abundance":12.1,"rank":3717,"name":"F5","annotation":"Coagulation factor V heavy chain; Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin; Belongs to the multicopper oxidase family."},{"id":"ENSMUSP00000034215","abundance":12.1,"rank":3718,"name":"Mt1","annotation":"Metallothionein-1; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family."},{"id":"ENSMUSP00000027601","abundance":12.1,"rank":3719,"name":"Mcm6","annotation":"DNA replication licensing factor MCM6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] "},{"id":"ENSMUSP00000105491","abundance":12.1,"rank":3720,"name":"Fam110a","annotation":"Protein FAM110A; Belongs to the FAM110 family."},{"id":"ENSMUSP00000074958","abundance":12.1,"rank":3721,"name":"Serpinb9f","annotation":"Serine (Or cysteine) peptidase inhibitor, clade B, member 9f; Belongs to the serpin family."},{"id":"ENSMUSP00000125314","abundance":12.1,"rank":3722,"name":"Tmem167","annotation":"Protein kish-A; Involved in the early part of the secretory pathway."},{"id":"ENSMUSP00000084097","abundance":12,"rank":3723,"name":"Armcx3","annotation":"Armadillo repeat-containing X-linked protein 3; Regulates mitochondrial aggregation and transport in axons in living neurons. May link mitochondria to the Trak2-kinesin motor complex via its interaction with Miro and Trak2. Mitochondrial distribution and dynamics is regulated through Armcx3 protein degradation, which is promoted by PCK and negatively regulated by Wnt1. Enhances the Sox10-mediated transactivation of the neuronal acetylcholine receptor subunit alpha-3 and beta-4 subunit gene promoters ; Belongs to the eutherian X-chromosome-specific Armcx family."},{"id":"ENSMUSP00000030698","abundance":12,"rank":3724,"name":"Stx12","annotation":"Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity)."},{"id":"ENSMUSP00000144481","abundance":12,"rank":3725,"name":"Rogdi","annotation":"Protein rogdi homolog; Belongs to the rogdi family."},{"id":"ENSMUSP00000123374","abundance":12,"rank":3726,"name":"Ccdc6","annotation":"Coiled-coil domain-containing protein 6."},{"id":"ENSMUSP00000044072","abundance":12,"rank":3727,"name":"Hpse","annotation":"Heparanase 50 kDa subunit; Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying a 2-O-sulfo group, but not linkages between a glucuronic acid unit and a 2-O-sulfated iduronic acid moiety. It is essentially [...] "},{"id":"ENSMUSP00000020528","abundance":12,"rank":3728,"name":"Mpg","annotation":"DNA-3-methyladenine glycosylase; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions."},{"id":"ENSMUSP00000028081","abundance":12,"rank":3729,"name":"Plxdc2","annotation":"Plexin domain-containing protein 2; May play a role in tumor angiogenesis. Belongs to the plexin family."},{"id":"ENSMUSP00000023361","abundance":12,"rank":3730,"name":"Pdxdc1","annotation":"Pyridoxal-dependent decarboxylase domain-containing protein 1; Belongs to the group II decarboxylase family."},{"id":"ENSMUSP00000033313","abundance":12,"rank":3731,"name":"Atp6ap2","annotation":"Renin receptor extracellular fragment; Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the proton- transporting vacuolar (V)-ATPase protein pump. May mediate renin- dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity). Probably by controlling the assembly of the V- ATPase pump and thus the acidification of the endo-lysosomal system, plays a  [...] "},{"id":"ENSMUSP00000112044","abundance":12,"rank":3732,"name":"Slc25a51","annotation":"Solute carrier family 25 member 51."},{"id":"ENSMUSP00000110898","abundance":12,"rank":3733,"name":"Opcml","annotation":"Opioid-binding protein/cell adhesion molecule-like."},{"id":"ENSMUSP00000053543","abundance":12,"rank":3734,"name":"Meaf6","annotation":"Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vi [...] "},{"id":"ENSMUSP00000152109","abundance":12,"rank":3735,"name":"Vrk1","annotation":"Serine/threonine-protein kinase VRK1; Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain- containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosph [...] "},{"id":"ENSMUSP00000142766","abundance":12,"rank":3736,"name":"Amph","annotation":"Amphiphysin; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton (By similarity)."},{"id":"ENSMUSP00000149509","abundance":12,"rank":3737,"name":"Olfr1089","annotation":"Olfactory receptor 1089."},{"id":"ENSMUSP00000109904","abundance":12,"rank":3738,"name":"Clic3","annotation":"Chloride intracellular channel protein 3; Can insert into membranes and form chloride ion channels. May participate in cellular growth control (By similarity); Belongs to the chloride channel CLIC family."},{"id":"ENSMUSP00000070052","abundance":12,"rank":3739,"name":"Ndrg3","annotation":"Protein NDRG3; Belongs to the NDRG family."},{"id":"ENSMUSP00000024047","abundance":11.9,"rank":3740,"name":"Twf2","annotation":"Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia; Belongs to the actin-binding proteins ADF family. Twinfilin subfamily."},{"id":"ENSMUSP00000105822","abundance":11.9,"rank":3741,"name":"Tfap2a","annotation":"Transcription factor AP-2-alpha; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 [...] "},{"id":"ENSMUSP00000073268","abundance":11.9,"rank":3742,"name":"Prkg1","annotation":"cGMP-dependent protein kinase 1; Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins. Numerous protein targets for PRKG1 phosphorylation are implicated in modulating cellular calcium, but the contribution of each of these targets may vary substantially among cell types. Proteins that are phosphorylated by PRKG1 regulate platelet activation and adhesion, smooth muscle contraction, cardiac function, gene expression, feedback of the NO-s [...] "},{"id":"ENSMUSP00000112110","abundance":11.9,"rank":3743,"name":"Hdac7","annotation":"Histone deacetylase 7; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression  [...] "},{"id":"ENSMUSP00000049285","abundance":11.9,"rank":3744,"name":"Colec11","annotation":"Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis [...] "},{"id":"ENSMUSP00000036725","abundance":11.9,"rank":3745,"name":"Mrps2","annotation":"28S ribosomal protein S2, mitochondrial; Required for mitoribosome formation and stability, and mitochondrial translation."},{"id":"ENSMUSP00000041831","abundance":11.9,"rank":3746,"name":"Rbm17","annotation":"Splicing factor 45; Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites (By similarity)."},{"id":"ENSMUSP00000023807","abundance":11.9,"rank":3747,"name":"Igfbp6","annotation":"Insulin-like growth factor-binding protein 6; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors."},{"id":"ENSMUSP00000070871","abundance":11.9,"rank":3748,"name":"Pgm3","annotation":"Phosphoacetylglucosamine mutase; Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O- glycosylation; Belongs to the phosphohexose mutase family."},{"id":"ENSMUSP00000015484","abundance":11.9,"rank":3749,"name":"Cybb","annotation":"Cytochrome b-245 heavy chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes."},{"id":"ENSMUSP00000015998","abundance":11.9,"rank":3750,"name":"Cd5l","annotation":"CD5 antigen-like; Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of [...] "},{"id":"ENSMUSP00000090926","abundance":11.9,"rank":3751,"name":"Mtif2","annotation":"Translation initiation factor IF-2, mitochondrial; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)."},{"id":"ENSMUSP00000129739","abundance":11.9,"rank":3752,"name":"Eps15l1","annotation":"Epidermal growth factor receptor substrate 15-like 1; Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2 (By similarity)."},{"id":"ENSMUSP00000142184","abundance":11.9,"rank":3753,"name":"Tbl1xr1","annotation":"F-box-like/WD repeat-containing protein TBL1XR1; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity)."},{"id":"ENSMUSP00000154609","abundance":11.9,"rank":3754,"name":"Eppk1","annotation":"Epiplakin; Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress. In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture. However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epitheliu [...] "},{"id":"ENSMUSP00000064668","abundance":11.9,"rank":3755,"name":"Nudcd3","annotation":"NudC domain-containing protein 3."},{"id":"ENSMUSP00000053900","abundance":11.9,"rank":3756,"name":"Zmpste24","annotation":"CAAX prenyl protease 1 homolog; Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C."},{"id":"ENSMUSP00000126565","abundance":11.8,"rank":3757,"name":"Lsm5","annotation":"U6 snRNA-associated Sm-like protein LSm5; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA."},{"id":"ENSMUSP00000096458","abundance":11.8,"rank":3758,"name":"Tnni3","annotation":"Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity."},{"id":"ENSMUSP00000034405","abundance":11.8,"rank":3759,"name":"Mre11a","annotation":"Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] "},{"id":"ENSMUSP00000092673","abundance":11.8,"rank":3760,"name":"Inip","annotation":"SOSS complex subunit C; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). Belongs to the SOSS-C family."},{"id":"ENSMUSP00000052648","abundance":11.8,"rank":3761,"name":"Ar","annotation":"Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DA [...] "},{"id":"ENSMUSP00000111327","abundance":11.8,"rank":3762,"name":"Slc35a2","annotation":"UDP-galactose translocator; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function."},{"id":"ENSMUSP00000034878","abundance":11.8,"rank":3763,"name":"Tmem30a","annotation":"Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex.  [...] "},{"id":"ENSMUSP00000030121","abundance":11.8,"rank":3764,"name":"B4galt1","annotation":"Processed beta-1,4-galactosyltransferase 1; The Golgi complex form catalyzes the production of lactose in the lactating mammary gland and could also be responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the glycosyltransferase 7 family."},{"id":"ENSMUSP00000078875","abundance":11.8,"rank":3765,"name":"Fcer1g","annotation":"High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a funct [...] "},{"id":"ENSMUSP00000018841","abundance":11.8,"rank":3766,"name":"Aatf","annotation":"Protein AATF; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression (By similarity). Belongs to the AATF family."},{"id":"ENSMUSP00000039763","abundance":11.8,"rank":3767,"name":"Dbil5","annotation":"Diazepam-binding inhibitor-like 5; May be involved in the energy metabolism of the mature sperm; Belongs to the ACBP family."},{"id":"ENSMUSP00000101477","abundance":11.8,"rank":3768,"name":"Pithd1","annotation":"PITH domain-containing protein 1; Promotes megakaryocyte differentiation by up-regulating RUNX1 expression. Regulates RUNX1 expression by activating the proximal promoter of the RUNX1 gene and by enhancing the translation activity of an internal ribosome entry site (IRES) element in the RUNX1 gene (By similarity)."},{"id":"ENSMUSP00000067552","abundance":11.8,"rank":3769,"name":"Srr","annotation":"Serine racemase; Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine."},{"id":"ENSMUSP00000117971","abundance":11.8,"rank":3770,"name":"Mrpl17","annotation":"39S ribosomal protein L17, mitochondrial."},{"id":"ENSMUSP00000063656","abundance":11.7,"rank":3771,"name":"Neo1","annotation":"Neogenin; Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response."},{"id":"ENSMUSP00000131941","abundance":11.7,"rank":3772,"name":"Smim12","annotation":"Small integral membrane protein 12."},{"id":"ENSMUSP00000018572","abundance":11.7,"rank":3773,"name":"Akap1","annotation":"A-kinase anchor protein 1, mitochondrial; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4  [...] "},{"id":"ENSMUSP00000152948","abundance":11.7,"rank":3774,"name":"Hdgfl2","annotation":"Hepatoma-derived growth factor-related protein 2; Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity). Associates with chromatin. Isoform 1 and isoform 3 bind to condensed chromatin in mitotic cells. Isoform 4 binds to non-condensed chromatin in the presence of HDGF."},{"id":"ENSMUSP00000140903","abundance":11.7,"rank":3775,"name":"Nek7","annotation":"Serine/threonine-protein kinase Nek7; Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1."},{"id":"ENSMUSP00000104703","abundance":11.7,"rank":3776,"name":"Nelfcd","annotation":"Negative elongation factor D; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity)."},{"id":"ENSMUSP00000003513","abundance":11.7,"rank":3777,"name":"Nosip","annotation":"Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB. Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity (By similarity); Belongs to the NOSIP family."},{"id":"ENSMUSP00000099046","abundance":11.7,"rank":3778,"name":"Ids","annotation":"Iduronate 2-sulfatase; Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate."},{"id":"ENSMUSP00000120741","abundance":11.7,"rank":3779,"name":"Tpsab1","annotation":"Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity (By similarity). Belongs to the peptidase S1 family. Tryptase subfamily."},{"id":"ENSMUSP00000098768","abundance":11.7,"rank":3780,"name":"Sod3","annotation":"Extracellular superoxide dismutase [Cu-Zn]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen."},{"id":"ENSMUSP00000071788","abundance":11.7,"rank":3781,"name":"Elac2","annotation":"Zinc phosphodiesterase ELAC protein 2; Zinc phosphodiesterase, which displays mitochondrial tRNA 3'- processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity). Belongs to the RNase Z family."},{"id":"ENSMUSP00000098212","abundance":11.7,"rank":3782,"name":"Clip2","annotation":"CAP-Gly domain-containing linker protein 2; Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations (By similarity)."},{"id":"ENSMUSP00000125081","abundance":11.6,"rank":3783,"name":"Tnik","annotation":"Traf2 and NCK-interacting protein kinase; Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N- terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate [...] "},{"id":"ENSMUSP00000044497","abundance":11.6,"rank":3784,"name":"Mrpl34","annotation":"39S ribosomal protein L34, mitochondrial; Belongs to the bacterial ribosomal protein bL34 family."},{"id":"ENSMUSP00000000896","abundance":11.6,"rank":3785,"name":"Pxmp4","annotation":"Peroxisomal membrane protein 4; Belongs to the peroxisomal membrane protein PXMP2/4 family."},{"id":"ENSMUSP00000022497","abundance":11.6,"rank":3786,"name":"Spryd7","annotation":"SPRY domain-containing protein 7."},{"id":"ENSMUSP00000054322","abundance":11.6,"rank":3787,"name":"Stbd1","annotation":"Starch-binding domain-containing protein 1; Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes."},{"id":"ENSMUSP00000073911","abundance":11.6,"rank":3788,"name":"Smyd1","annotation":"Histone-lysine N-methyltransferase Smyd1; Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis."},{"id":"ENSMUSP00000049819","abundance":11.6,"rank":3789,"name":"Serpinb9h","annotation":"Serine (or cysteine) peptidase inhibitor, clade B, member 9h; Belongs to the serpin family."},{"id":"ENSMUSP00000137309","abundance":11.6,"rank":3790,"name":"H1f0","annotation":"Histone H1.0, N-terminally processed; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division."},{"id":"ENSMUSP00000028467","abundance":11.6,"rank":3791,"name":"Prg2","annotation":"Eosinophil granule major basic protein; Cytotoxin and helminthotoxin. MBP also induces non-cytolytic histamine release from basophils. It is involved in antiparasitic defense mechanisms and immune hypersensitivity reactions (By similarity)."},{"id":"ENSMUSP00000031032","abundance":11.6,"rank":3792,"name":"Ppm1g","annotation":"Protein phosphatase 1G; May be involved in regulation of cell cycle. Belongs to the PP2C family."},{"id":"ENSMUSP00000033450","abundance":11.6,"rank":3793,"name":"Gpc4","annotation":"Secreted glypican-4; Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system."},{"id":"ENSMUSP00000001147","abundance":11.6,"rank":3794,"name":"Col6a1","annotation":"Collagen alpha-1(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family."},{"id":"ENSMUSP00000029717","abundance":11.6,"rank":3795,"name":"Cd1d1","annotation":"Antigen-presenting glycoprotein CD1d1; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells."},{"id":"ENSMUSP00000045927","abundance":11.6,"rank":3796,"name":"Fam210a","annotation":"Protein FAM210A; May play a role in the structure and strength of both muscle and bone."},{"id":"ENSMUSP00000117052","abundance":11.6,"rank":3797,"name":"Derl2","annotation":"Derlin-2; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the  [...] "},{"id":"ENSMUSP00000076533","abundance":11.6,"rank":3798,"name":"Ptpra","annotation":"Receptor-type tyrosine-protein phosphatase alpha; Tyrosine protein phosphatase which is involved in integrin- mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42 ; Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily."},{"id":"ENSMUSP00000106025","abundance":11.5,"rank":3799,"name":"Max","annotation":"Protein max; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. CpG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the MYC:MAX complex in vivo. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box ele [...] "},{"id":"ENSMUSP00000125403","abundance":11.5,"rank":3800,"name":"Cul2","annotation":"Cullin-2; Core component of multiple cullin-RING-based ECS (ElonginB/C- CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the associati [...] "},{"id":"ENSMUSP00000095134","abundance":11.5,"rank":3801,"name":"Tor1aip1","annotation":"Torsin-1A-interacting protein 1; Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina."},{"id":"ENSMUSP00000034749","abundance":11.5,"rank":3802,"name":"Fam81a","annotation":"Protein FAM81A; Belongs to the FAM81 family."},{"id":"ENSMUSP00000029752","abundance":11.5,"rank":3803,"name":"Tars2","annotation":"Threonine--tRNA ligase, mitochondrial; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000025183","abundance":11.5,"rank":3804,"name":"Ring1","annotation":"E3 ubiquitin-protein ligase RING1; Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG P [...] "},{"id":"ENSMUSP00000077040","abundance":11.5,"rank":3805,"name":"Vps13c","annotation":"Vacuolar protein sorting-associated protein 13C; Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization."},{"id":"ENSMUSP00000036747","abundance":11.5,"rank":3806,"name":"C1qc","annotation":"Complement C1q subcomponent subunit C; C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes."},{"id":"ENSMUSP00000029915","abundance":11.5,"rank":3807,"name":"Tstd3","annotation":"Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 3."},{"id":"ENSMUSP00000083205","abundance":11.5,"rank":3808,"name":"Clasrp","annotation":"CLK4-associating serine/arginine rich protein; Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family."},{"id":"ENSMUSP00000095171","abundance":11.5,"rank":3809,"name":"Cd74","annotation":"H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44."},{"id":"ENSMUSP00000074681","abundance":11.5,"rank":3810,"name":"Cdh11","annotation":"Cadherin-11; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."},{"id":"ENSMUSP00000027114","abundance":11.5,"rank":3811,"name":"Maip1","annotation":"m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB)."},{"id":"ENSMUSP00000078207","abundance":11.4,"rank":3812,"name":"Prpf38a","annotation":"Pre-mRNA-splicing factor 38A; Involved in pre-mRNA splicing as a component of the spliceosome; Belongs to the PRP38 family."},{"id":"ENSMUSP00000102904","abundance":11.4,"rank":3813,"name":"Snx27","annotation":"Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing e [...] "},{"id":"ENSMUSP00000034311","abundance":11.4,"rank":3814,"name":"Lsm4","annotation":"U6 snRNA-associated Sm-like protein LSm4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA."},{"id":"ENSMUSP00000118751","abundance":11.4,"rank":3815,"name":"Ankfy1","annotation":"Rabankyrin-5; Proposed effector of Rab5. Binds to phosphatidylinositol 3- phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to- Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a re [...] "},{"id":"ENSMUSP00000029005","abundance":11.4,"rank":3816,"name":"Rtf2","annotation":"Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. Belongs to the rtf2 family."},{"id":"ENSMUSP00000046732","abundance":11.4,"rank":3817,"name":"Nup43","annotation":"Nucleoporin Nup43; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity)."},{"id":"ENSMUSP00000048555","abundance":11.4,"rank":3818,"name":"Cpe","annotation":"Carboxypeptidase E; Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. Belongs to the peptidase M14 family."},{"id":"ENSMUSP00000034173","abundance":11.4,"rank":3819,"name":"Ces1e","annotation":"Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs."},{"id":"ENSMUSP00000138753","abundance":11.4,"rank":3820,"name":"Ank2","annotation":"Ankyrin-2; Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic ret [...] "},{"id":"ENSMUSP00000128819","abundance":11.4,"rank":3821,"name":"Nup155","annotation":"Nuclear pore complex protein Nup155; Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Belongs to the non-repetitive/WGA-negative nucleoporin family."},{"id":"ENSMUSP00000036924","abundance":11.4,"rank":3822,"name":"Ccar2","annotation":"Cell cycle and apoptosis regulator protein 2; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53- mediated apoptosis (By similarity). As part of a histone H3-specific meth [...] "},{"id":"ENSMUSP00000002757","abundance":11.4,"rank":3823,"name":"Cox16","annotation":"Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial; Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Promotes the insertion of copper into the active site of cytochrome c oxidase subunit II (MT-CO2/COX2). Interacts specifically with newly synthesized MT-CO2/COX and its copper center-forming metallochaperones SCO1, SCO2 and COA6. Probably facilitates MT-CO2/COX2 association with the MITRAC assembly intermediate containing MT-CO1/COX1, thereby participating in merging the MT-CO1/COX1 and MT-CO2/COX2 ass [...] "},{"id":"ENSMUSP00000035687","abundance":11.4,"rank":3824,"name":"H2-M3","annotation":"Histocompatibility 2, M region locus 3; Belongs to the MHC class I family."},{"id":"ENSMUSP00000099483","abundance":11.4,"rank":3825,"name":"Car4","annotation":"Carbonic anhydrase 4; Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 (By similarity)."},{"id":"ENSMUSP00000120778","abundance":11.4,"rank":3826,"name":"Lyrm7","annotation":"Complex III assembly factor LYRM7; Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane (By similarity)."},{"id":"ENSMUSP00000105047","abundance":11.4,"rank":3827,"name":"Gdap1l1","annotation":"Ganglioside-induced differentiation-associated protein 1-like 1; Belongs to the GST superfamily."},{"id":"ENSMUSP00000120014","abundance":11.4,"rank":3828,"name":"Nhp2","annotation":"H/ACA ribonucleoprotein complex subunit 2; Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse tran [...] "},{"id":"ENSMUSP00000034249","abundance":11.4,"rank":3829,"name":"Cfap20","annotation":"Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity)."},{"id":"ENSMUSP00000029257","abundance":11.3,"rank":3830,"name":"Atp11b","annotation":"Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily."},{"id":"ENSMUSP00000027050","abundance":11.3,"rank":3831,"name":"Cops5","annotation":"COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Promotes the proteasomal degradation of BRSK2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, [...] "},{"id":"ENSMUSP00000107544","abundance":11.3,"rank":3832,"name":"Odr4","annotation":"Protein odr-4 homolog; May play a role in the trafficking of a subset of G-protein coupled receptors; Belongs to the ODR-4 family."},{"id":"ENSMUSP00000015481","abundance":11.3,"rank":3833,"name":"Endog","annotation":"Endonuclease G, mitochondrial; Cleaves DNA at double-stranded (DG)n.(DC)n and at single- stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA (By similarity)."},{"id":"ENSMUSP00000003370","abundance":11.3,"rank":3834,"name":"Hck","annotation":"Tyrosine-protein kinase HCK; Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic p [...] "},{"id":"ENSMUSP00000073803","abundance":11.3,"rank":3835,"name":"Otof","annotation":"Otoferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes."},{"id":"ENSMUSP00000144989","abundance":11.3,"rank":3836,"name":"Zfp638","annotation":"Zinc finger protein 638; Transcription factor that binds to cytidine clusters in double-stranded DNA (By similarity). Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4. Act [...] "},{"id":"ENSMUSP00000054141","abundance":11.3,"rank":3837,"name":"Eva1b","annotation":"Protein eva-1 homolog B."},{"id":"ENSMUSP00000117583","abundance":11.3,"rank":3838,"name":"Micos10","annotation":"MICOS complex subunit Mic10; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane."},{"id":"ENSMUSP00000096498","abundance":11.3,"rank":3839,"name":"Defa23","annotation":"Defensin, alpha, 23."},{"id":"ENSMUSP00000096495","abundance":11.3,"rank":3840,"name":"Defa31","annotation":"Alpha-defensin 23; May have microbicidal activities; Belongs to the alpha-defensin family."},{"id":"ENSMUSP00000112632","abundance":11.3,"rank":3841,"name":"Ube4a","annotation":"Ubiquitin conjugation factor E4 A; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates."},{"id":"ENSMUSP00000030551","abundance":11.3,"rank":3842,"name":"Alpl","annotation":"Alkaline phosphatase, tissue-nonspecific isozyme; This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi)."},{"id":"ENSMUSP00000029128","abundance":11.3,"rank":3843,"name":"Map1lc3a","annotation":"Microtubule-associated proteins 1A/1B light chain 3A; Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation."},{"id":"ENSMUSP00000105743","abundance":11.3,"rank":3844,"name":"Plcb1","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes."},{"id":"ENSMUSP00000028848","abundance":11.3,"rank":3845,"name":"Fahd2a","annotation":"Fumarylacetoacetate hydrolase domain-containing protein 2A; May have hydrolase activity."},{"id":"ENSMUSP00000029804","abundance":11.3,"rank":3846,"name":"Metap1","annotation":"Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val)."},{"id":"ENSMUSP00000132780","abundance":11.3,"rank":3847,"name":"Idi1","annotation":"Isopentenyl-diphosphate Delta-isomerase 1; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)."},{"id":"ENSMUSP00000009058","abundance":11.3,"rank":3848,"name":"Abcb1b","annotation":"ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily."},{"id":"ENSMUSP00000034281","abundance":11.2,"rank":3849,"name":"6430548M08Rik","annotation":"Uncharacterized protein KIAA0513."},{"id":"ENSMUSP00000105850","abundance":11.2,"rank":3850,"name":"Col14a1","annotation":"Collagen alpha-1(XIV) chain; Plays an adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors (By similarity)."},{"id":"ENSMUSP00000126197","abundance":11.2,"rank":3851,"name":"Krt78","annotation":"Keratin 78; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000137317","abundance":11.2,"rank":3852,"name":"Gm6803","annotation":"Predicted gene 6803; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000152354","abundance":11.2,"rank":3853,"name":"Gm2022","annotation":"Predicted pseudogene 2022; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000074953","abundance":11.2,"rank":3854,"name":"Safb2","annotation":"Scaffold attachment factor B2; Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation (By similarity)."},{"id":"ENSMUSP00000066880","abundance":11.2,"rank":3855,"name":"Cadm4","annotation":"Cell adhesion molecule 4; Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity."},{"id":"ENSMUSP00000003720","abundance":11.2,"rank":3856,"name":"Crot","annotation":"Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate."},{"id":"ENSMUSP00000085985","abundance":11.2,"rank":3857,"name":"Kif21a","annotation":"Kinesin-like protein KIF21A; Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family."},{"id":"ENSMUSP00000112926","abundance":11.2,"rank":3858,"name":"Zfp617","annotation":"Zinc finger protein 617."},{"id":"ENSMUSP00000035579","abundance":11.2,"rank":3859,"name":"Lgals3bp","annotation":"Galectin-3-binding protein; Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity)."},{"id":"ENSMUSP00000035077","abundance":11.2,"rank":3860,"name":"Ltf","annotation":"Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites."},{"id":"ENSMUSP00000034349","abundance":11.2,"rank":3861,"name":"Nae1","annotation":"NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (By similarity); Belongs to the ubiquitin-activating E1 family. ULA1 subfamily."},{"id":"ENSMUSP00000023099","abundance":11.2,"rank":3862,"name":"Slc38a2","annotation":"Sodium-coupled neutral amino acid transporter 2; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta."},{"id":"ENSMUSP00000034053","abundance":11.2,"rank":3863,"name":"Pdlim3","annotation":"PDZ and LIM domain protein 3; May play a role in the organization of actin filament arrays within muscle cells."},{"id":"ENSMUSP00000123078","abundance":11.2,"rank":3864,"name":"Dlgap2","annotation":"Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane."},{"id":"ENSMUSP00000033939","abundance":11.2,"rank":3865,"name":"Ikbkb","annotation":"Inhibitor of nuclear factor kappa-B kinase subunit beta; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is transloca [...] "},{"id":"ENSMUSP00000144171","abundance":11.2,"rank":3866,"name":"Pds5a","annotation":"Sister chromatid cohesion protein PDS5 homolog A; Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity)."},{"id":"ENSMUSP00000111101","abundance":11.2,"rank":3867,"name":"Gtpbp10","annotation":"GTP-binding protein 10; May be involved in the ribosome maturation process. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family."},{"id":"ENSMUSP00000079667","abundance":11.2,"rank":3868,"name":"Ipo11","annotation":"Importin-11; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] "},{"id":"ENSMUSP00000099661","abundance":11.2,"rank":3869,"name":"Trappc1","annotation":"Trafficking protein particle complex subunit 1; May play a role in vesicular transport from endoplasmic reticulum to Golgi."},{"id":"ENSMUSP00000080414","abundance":11.2,"rank":3870,"name":"Hoga1","annotation":"4-hydroxy-2-oxoglutarate aldolase, mitochondrial; Catalyzes the final step in the metabolic pathway of hydroxyproline."},{"id":"ENSMUSP00000132082","abundance":11.2,"rank":3871,"name":"Iars","annotation":"Isoleucine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA; Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000020234","abundance":11.2,"rank":3872,"name":"Timp3","annotation":"Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli."},{"id":"ENSMUSP00000047844","abundance":11.2,"rank":3873,"name":"Chad","annotation":"Chondroadherin; Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily."},{"id":"ENSMUSP00000073847","abundance":11.2,"rank":3874,"name":"Cpne6","annotation":"Copine-6; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner. Plays a role in dendrite formation by melanocytes (By similarity). Belongs to the copine family."},{"id":"ENSMUSP00000006217","abundance":11.2,"rank":3875,"name":"Snf8","annotation":"Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with  [...] "},{"id":"ENSMUSP00000027866","abundance":11.1,"rank":3876,"name":"Blzf1","annotation":"Golgin-45; Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface."},{"id":"ENSMUSP00000053288","abundance":11.1,"rank":3877,"name":"Onecut3","annotation":"One cut domain family member 3; Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR."},{"id":"ENSMUSP00000037487","abundance":11.1,"rank":3878,"name":"Cyp7b1","annotation":"Cytochrome P450 7B1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous oxysterols and steroid hormones, including neurosteroids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of steroids with a preference for 7-alpha position. Usually metabolizes steroids carrying a hydroxy group at position 3, functioning as a 3-hydroxy  [...] "},{"id":"ENSMUSP00000084772","abundance":11.1,"rank":3879,"name":"Col11a2","annotation":"Collagen alpha-2(XI) chain; May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils; Belongs to the fibrillar collagen family."},{"id":"ENSMUSP00000020382","abundance":11.1,"rank":3880,"name":"Yeats4","annotation":"YEATS domain-containing protein 4; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and repl [...] "},{"id":"ENSMUSP00000028917","abundance":11.1,"rank":3881,"name":"Dtd1","annotation":"D-aminoacyl-tRNA deacylase 1; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality."},{"id":"ENSMUSP00000050497","abundance":11.1,"rank":3882,"name":"Epx","annotation":"Eosinophil peroxidase heavy chain; Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils; Belongs to the peroxidase family. XPO subfamily."},{"id":"ENSMUSP00000035061","abundance":11.1,"rank":3883,"name":"Ngp","annotation":"Neutrophilic granule protein; Acts as an inhibitor of cathepsin B (CTSB) activity. Plays a role as a negative regulator of tumor vascular development, cell invasion and metastasis."},{"id":"ENSMUSP00000087562","abundance":11.1,"rank":3884,"name":"Arvcf","annotation":"Armadillo repeat protein deleted in velo-cardio-facial syndrome homolog; Involved in protein-protein interactions at adherens junctions."},{"id":"ENSMUSP00000090884","abundance":11.1,"rank":3885,"name":"Dock2","annotation":"Dedicator of cytokinesis protein 2; Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2."},{"id":"ENSMUSP00000049186","abundance":11.1,"rank":3886,"name":"Gfer","annotation":"FAD-linked sulfhydryl oxidase ALR; FAD-dependent sulfhydryl oxidase that regenerates the redox- active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen (By similarity)."},{"id":"ENSMUSP00000022028","abundance":11.1,"rank":3887,"name":"1700067P10Rik","annotation":"RIKEN cDNA 1700067P10 gene."},{"id":"ENSMUSP00000097071","abundance":11.1,"rank":3888,"name":"Cyp2c68","annotation":"Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000026990","abundance":11.1,"rank":3889,"name":"Thoc3","annotation":"THO complex subunit 3; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cy [...] "},{"id":"ENSMUSP00000069443","abundance":11.1,"rank":3890,"name":"Wiz","annotation":"Protein Wiz; May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000030299","abundance":11.1,"rank":3891,"name":"Cyp2j5","annotation":"Cytochrome P450 2J5."},{"id":"ENSMUSP00000066860","abundance":11.1,"rank":3892,"name":"Hspa12a","annotation":"Heat shock 70 kDa protein 12A; Adapter protein for SORL1, but not SORT1. Delays SORL1 internalization and affects SORL1 subcellular localization. Belongs to the heat shock protein 70 family."},{"id":"ENSMUSP00000081572","abundance":11.1,"rank":3893,"name":"Prpf4","annotation":"U4/U6 small nuclear ribonucleoprotein Prp4; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)."},{"id":"ENSMUSP00000026585","abundance":11.1,"rank":3894,"name":"Tspan4","annotation":"Tetraspanin-4; Belongs to the tetraspanin (TM4SF) family."},{"id":"ENSMUSP00000099066","abundance":11.1,"rank":3895,"name":"Atp11c","annotation":"Phospholipid-transporting ATPase 11C; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for [...] "},{"id":"ENSMUSP00000021313","abundance":11.1,"rank":3896,"name":"Dcakd","annotation":"Dephospho-CoA kinase domain-containing protein; Belongs to the CoaE family."},{"id":"ENSMUSP00000047397","abundance":11,"rank":3897,"name":"Sart1","annotation":"U4/U6.U5 tri-snRNP-associated protein 1; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA. Appears to play a role in hypoxia-induced regulation of EPO gene expression; Belongs to the SNU66/SART1 family."},{"id":"ENSMUSP00000021380","abundance":11,"rank":3898,"name":"Trappc6b","annotation":"Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (By similarity). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (By similarity). Belongs to the TRAPP small subunits family. BET3 subfamily."},{"id":"ENSMUSP00000018653","abundance":11,"rank":3899,"name":"Cenpv","annotation":"Centromere protein V; Required for distribution of pericentromeric heterochromatin in interphase nuclei and for centromere formation and organization, chromosome alignment and cytokinesis; Belongs to the Gfa family."},{"id":"ENSMUSP00000001047","abundance":11,"rank":3900,"name":"S100a3","annotation":"Protein S100-A3; Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation (By similarity)."},{"id":"ENSMUSP00000022865","abundance":11,"rank":3901,"name":"Mtdh","annotation":"Protein LYRIC; Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance (By similarity)."},{"id":"ENSMUSP00000097901","abundance":11,"rank":3902,"name":"Rbm26","annotation":"RNA-binding protein 26."},{"id":"ENSMUSP00000018880","abundance":11,"rank":3903,"name":"Ndel1","annotation":"Nuclear distribution protein nudE-like 1; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripe [...] "},{"id":"ENSMUSP00000026735","abundance":11,"rank":3904,"name":"Ccdc51","annotation":"Mitochondrial potassium channel; Mitochondrial potassium channel located in the mitochondrial inner membrane. Together with ABCB8/MITOSUR, forms a protein complex localized in the mitochondria that mediates ATP- dependent potassium currents across the inner membrane (that is, mitoK(ATP) channel). May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume."},{"id":"ENSMUSP00000031053","abundance":11,"rank":3905,"name":"Khk","annotation":"Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate."},{"id":"ENSMUSP00000067046","abundance":11,"rank":3906,"name":"Lep","annotation":"Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal met [...] "},{"id":"ENSMUSP00000133805","abundance":11,"rank":3907,"name":"Lig3","annotation":"DNA ligase 3; The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase."},{"id":"ENSMUSP00000089691","abundance":11,"rank":3908,"name":"Rdh16f2","annotation":"Cis-retinol/3alpha hydroxysterol short-chain dehydrogenase-like protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000159109","abundance":11,"rank":3909,"name":"Cgn","annotation":"Cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the cingulin family."},{"id":"ENSMUSP00000027518","abundance":11,"rank":3910,"name":"Spp2","annotation":"Secreted phosphoprotein 24; Could coordinate an aspect of bone turnover."},{"id":"ENSMUSP00000098097","abundance":11,"rank":3911,"name":"Ube2z","annotation":"Ubiquitin-conjugating enzyme E2 Z; Catalyzes the covalent attachment of ubiquitin to other proteins. Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation; Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000023294","abundance":11,"rank":3912,"name":"Rabl2","annotation":"Rab-like protein 2A; Plays an essential role in male fertility, sperm intra- flagellar transport, and tail assembly. Binds, in a GTP-regulated manner, to a specific set of effector proteins including key proteins involved in cilia development and function and delivers them into the growing sperm tail."},{"id":"ENSMUSP00000029694","abundance":11,"rank":3913,"name":"Arhgef2","annotation":"Rho guanine nucleotide exchange factor 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing system along with NOD1 for the detec [...] "},{"id":"ENSMUSP00000037377","abundance":11,"rank":3914,"name":"Fbxo2","annotation":"F-box only protein 2; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotransl [...] "},{"id":"ENSMUSP00000048222","abundance":11,"rank":3915,"name":"Mat2b","annotation":"Methionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. Can bind NADP (in vitro); Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily."},{"id":"ENSMUSP00000033093","abundance":10.9,"rank":3916,"name":"Bax","annotation":"Apoptosis regulator BAX; Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production; Belongs to the Bcl-2 family."},{"id":"ENSMUSP00000012627","abundance":10.9,"rank":3917,"name":"Rpa3","annotation":"Replication protein A 14 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRI [...] "},{"id":"ENSMUSP00000062174","abundance":10.9,"rank":3918,"name":"Wdr37","annotation":"WD repeat-containing protein 37."},{"id":"ENSMUSP00000087870","abundance":10.9,"rank":3919,"name":"Pax6","annotation":"Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity)."},{"id":"ENSMUSP00000101060","abundance":10.9,"rank":3920,"name":"Adora2a","annotation":"Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity)."},{"id":"ENSMUSP00000139010","abundance":10.9,"rank":3921,"name":"Gm28036","annotation":"Predicted gene, 28036."},{"id":"ENSMUSP00000046080","abundance":10.9,"rank":3922,"name":"Bpifa2","annotation":"BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa. Belongs to the BPI/LBP/Plunc superfamily. Plunc family."},{"id":"ENSMUSP00000048348","abundance":10.9,"rank":3923,"name":"Mrps35","annotation":"28S ribosomal protein S35, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS35 family."},{"id":"ENSMUSP00000098843","abundance":10.9,"rank":3924,"name":"Vamp5","annotation":"Vesicle-associated membrane protein 5; May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking; Belongs to the synaptobrevin family."},{"id":"ENSMUSP00000117009","abundance":10.9,"rank":3925,"name":"Pter","annotation":"Phosphotriesterase-related protein."},{"id":"ENSMUSP00000158026","abundance":10.9,"rank":3926,"name":"Nedd4l","annotation":"E3 ubiquitin-protein ligase NEDD4-like; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF- beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5. Promotes ubiquitination and  [...] "},{"id":"ENSMUSP00000158823","abundance":10.9,"rank":3927,"name":"Magt1","annotation":"Magnesium transporter protein 1; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulf [...] "},{"id":"ENSMUSP00000119829","abundance":10.9,"rank":3928,"name":"Vta1","annotation":"Vacuolar protein sorting-associated protein VTA1 homolog; Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies (By similarity). Involved in the sorting and down-regulation of EGFR; Belong [...] "},{"id":"ENSMUSP00000071378","abundance":10.9,"rank":3929,"name":"2310039H08Rik","annotation":"Uncharacterized protein C6orf226 homolog."},{"id":"ENSMUSP00000159068","abundance":10.9,"rank":3930,"name":"4930563E22Rik","annotation":"Uncharacterized protein C17orf100 homolog."},{"id":"ENSMUSP00000030158","abundance":10.9,"rank":3931,"name":"Dctn3","annotation":"Dynactin subunit 3; Together with dynein may be involved in spindle assembly and cytokinesis."},{"id":"ENSMUSP00000030014","abundance":10.9,"rank":3932,"name":"Ncbp1","annotation":"Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC  [...] "},{"id":"ENSMUSP00000026274","abundance":10.9,"rank":3933,"name":"Lztfl1","annotation":"Leucine zipper transcription factor-like protein 1; Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function. Belongs to the LZTFL1 family."},{"id":"ENSMUSP00000142514","abundance":10.9,"rank":3934,"name":"Gatad2b","annotation":"Transcriptional repressor p66-beta; Transcriptional repressor (By similarity). Enhances MBD2- mediated repression. Efficient repression requires the presence of GATAD2A (By similarity). Targets MBD3 to discrete loci in the nucleus (By similarity). Plays a role in synapse development (By similarity)."},{"id":"ENSMUSP00000032492","abundance":10.9,"rank":3935,"name":"Cd9","annotation":"CD9 antigen; Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleate [...] "},{"id":"ENSMUSP00000108260","abundance":10.8,"rank":3936,"name":"Steap3","annotation":"Metalloreductase STEAP3; Endosomal ferrireductase required for efficient transferrin- dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Also mediates reduction of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NADP(+) as acceptor. May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP; Belongs to the STEAP family."},{"id":"ENSMUSP00000052146","abundance":10.8,"rank":3937,"name":"Lancl2","annotation":"LanC-like protein 2; Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. Belongs to the LanC-like protein family."},{"id":"ENSMUSP00000133499","abundance":10.8,"rank":3938,"name":"Psmb9","annotation":"Proteasome subunit beta type-9; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Contributes to NFKBIA degradation and subsequently NFKB1 generation; Belongs to the peptidase T1B family."},{"id":"ENSMUSP00000138523","abundance":10.8,"rank":3939,"name":"Bin2","annotation":"Bridging integrator 2; Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Inhibits phagocytosis (By similarity). Plays a role in podosome formation."},{"id":"ENSMUSP00000032372","abundance":10.8,"rank":3940,"name":"Golt1b","annotation":"Vesicle transport protein GOT1B; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family."},{"id":"ENSMUSP00000029838","abundance":10.8,"rank":3941,"name":"Rpf1","annotation":"Ribosome production factor 1; May be required for ribosome biogenesis."},{"id":"ENSMUSP00000050076","abundance":10.8,"rank":3942,"name":"Adrm1","annotation":"Proteasomal ubiquitin receptor ADRM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engag [...] "},{"id":"ENSMUSP00000141274","abundance":10.8,"rank":3943,"name":"Gm9774","annotation":"Predicted pseudogene 9774."},{"id":"ENSMUSP00000029367","abundance":10.8,"rank":3944,"name":"Bche","annotation":"Cholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000124592","abundance":10.8,"rank":3945,"name":"Wdr26","annotation":"WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway throug [...] "},{"id":"ENSMUSP00000047845","abundance":10.8,"rank":3946,"name":"Dctpp1","annotation":"dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism."},{"id":"ENSMUSP00000124048","abundance":10.8,"rank":3947,"name":"Sirpa","annotation":"Tyrosine-protein phosphatase non-receptor type substrate 1; Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative re [...] "},{"id":"ENSMUSP00000125846","abundance":10.8,"rank":3948,"name":"Slc16a3","annotation":"Monocarboxylate transporter 4; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity); Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family."},{"id":"ENSMUSP00000156728","abundance":10.8,"rank":3949,"name":"Tjp2","annotation":"Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions."},{"id":"ENSMUSP00000094956","abundance":10.8,"rank":3950,"name":"Nelfe","annotation":"Negative elongation factor E; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity). Belongs to the RRM NELF-E family."},{"id":"ENSMUSP00000025732","abundance":10.8,"rank":3951,"name":"Slc25a45","annotation":"Solute carrier family 25 member 45."},{"id":"ENSMUSP00000031024","abundance":10.8,"rank":3952,"name":"Mrpl33","annotation":"39S ribosomal protein L33, mitochondrial; Belongs to the bacterial ribosomal protein bL33 family."},{"id":"ENSMUSP00000083844","abundance":10.8,"rank":3953,"name":"Pus1","annotation":"tRNA pseudouridine synthase A; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA. Isoforms 3 and 4 do not form pseudouridine when expressed in vitro."},{"id":"ENSMUSP00000044871","abundance":10.8,"rank":3954,"name":"Pigs","annotation":"GPI transamidase component PIG-S; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity); Belongs to the PIGS family."},{"id":"ENSMUSP00000028825","abundance":10.8,"rank":3955,"name":"Fam98b","annotation":"Protein FAM98B; Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation."},{"id":"ENSMUSP00000003027","abundance":10.8,"rank":3956,"name":"Map2k7","annotation":"Dual specificity mitogen-activated protein kinase kinase 7; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylati [...] "},{"id":"ENSMUSP00000034226","abundance":10.7,"rank":3957,"name":"Fam192a","annotation":"PSME3-interacting protein; Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus."},{"id":"ENSMUSP00000041204","abundance":10.7,"rank":3958,"name":"Abcb1a","annotation":"ATP-dependent translocase ABCB1; Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D- glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug- resistant cells (By similarity)."},{"id":"ENSMUSP00000099785","abundance":10.7,"rank":3959,"name":"Faf1","annotation":"FAS-associated factor 1; Ubiquitin-binding protein (By similarity). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (By similarity). Potentiates but cannot initiate FAS-induced apoptosis."},{"id":"ENSMUSP00000099756","abundance":10.7,"rank":3960,"name":"Nt5m","annotation":"5'(3')-deoxyribonucleotidase, mitochondrial; Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP; Belongs to the 5'(3')-deoxyribonucleotidase family."},{"id":"ENSMUSP00000072428","abundance":10.7,"rank":3961,"name":"Aplp2","annotation":"Amyloid-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein (By similarity). Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts."},{"id":"ENSMUSP00000113782","abundance":10.7,"rank":3962,"name":"Tm9sf1","annotation":"Transmembrane 9 superfamily member 1; Plays an essential role in autophagy; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family."},{"id":"ENSMUSP00000026409","abundance":10.7,"rank":3963,"name":"Ormdl2","annotation":"ORM1-like protein 2; Negative regulator of sphingolipid synthesis."},{"id":"ENSMUSP00000042207","abundance":10.7,"rank":3964,"name":"Ago2","annotation":"Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] "},{"id":"ENSMUSP00000041906","abundance":10.7,"rank":3965,"name":"Dis3","annotation":"Exosome complex exonuclease RRP44; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to t [...] "},{"id":"ENSMUSP00000073832","abundance":10.7,"rank":3966,"name":"Ndufaf3","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3; Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I)."},{"id":"ENSMUSP00000105774","abundance":10.7,"rank":3967,"name":"Gm2016","annotation":"Predicted gene 2016; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000001802","abundance":10.7,"rank":3968,"name":"Naglu","annotation":"Alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)."},{"id":"ENSMUSP00000033263","abundance":10.7,"rank":3969,"name":"Umod","annotation":"Uromodulin, secreted form; [Uromodulin]: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia."},{"id":"ENSMUSP00000036604","abundance":10.7,"rank":3970,"name":"Pdk3","annotation":"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial; Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species (By si [...] "},{"id":"ENSMUSP00000068468","abundance":10.7,"rank":3971,"name":"Itgam","annotation":"Integrin alpha-M; Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (By similarity). It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, require [...] "},{"id":"ENSMUSP00000020034","abundance":10.6,"rank":3972,"name":"Echdc1","annotation":"Ethylmalonyl-CoA decarboxylase; Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Also has methylmalonyl-CoA decarboxylase activity at lower level; Belongs to the enoyl-CoA hydratase/isomerase family."},{"id":"ENSMUSP00000152416","abundance":10.6,"rank":3973,"name":"Gm16368","annotation":"Predicted pseudogene 16368; Belongs to the eIF-1A family."},{"id":"ENSMUSP00000034136","abundance":10.6,"rank":3974,"name":"Gpt2","annotation":"Alanine aminotransferase 2; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate."},{"id":"ENSMUSP00000031633","abundance":10.6,"rank":3975,"name":"Cyp3a16","annotation":"Cytochrome P450 3A16; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000109761","abundance":10.6,"rank":3976,"name":"Stx18","annotation":"Syntaxin-18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER; Belongs to the syntaxin family."},{"id":"ENSMUSP00000049532","abundance":10.6,"rank":3977,"name":"Gja8","annotation":"Gap junction alpha-8 protein; Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore ; Belongs to the connexin family. Alpha-type (group II) subfamily."},{"id":"ENSMUSP00000065796","abundance":10.6,"rank":3978,"name":"Cyp2c67","annotation":"Cytochrome P450, family 2, subfamily c, polypeptide 67; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000078927","abundance":10.6,"rank":3979,"name":"H2-T22","annotation":"Histocompatibility 2, T region locus 22; Belongs to the MHC class I family."},{"id":"ENSMUSP00000033577","abundance":10.6,"rank":3980,"name":"Pbdc1","annotation":"Protein PBDC1."},{"id":"ENSMUSP00000047756","abundance":10.6,"rank":3981,"name":"Pabpc5","annotation":"Poly(A)-binding protein, cytoplasmic 5."},{"id":"ENSMUSP00000092602","abundance":10.6,"rank":3982,"name":"Klhl9","annotation":"Kelch-like protein 9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity)."},{"id":"ENSMUSP00000070322","abundance":10.6,"rank":3983,"name":"Syt5","annotation":"Synaptotagmin-5; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface; Belongs to the synaptotagmin family."},{"id":"ENSMUSP00000108046","abundance":10.6,"rank":3984,"name":"Zfp384","annotation":"Zinc finger protein 384."},{"id":"ENSMUSP00000139917","abundance":10.6,"rank":3985,"name":"Neil1","annotation":"Endonuclease 8-like 1; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/ly [...] "},{"id":"ENSMUSP00000101622","abundance":10.6,"rank":3986,"name":"Cd151","annotation":"CD151 antigen; Essential for the proper assembly of the glomerular and tubular basement membranes in kidney; Belongs to the tetraspanin (TM4SF) family."},{"id":"ENSMUSP00000002889","abundance":10.6,"rank":3987,"name":"Flii","annotation":"Protein flightless-1 homolog; May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity). Essential for early embryonic development. May play a role in regulation of cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation."},{"id":"ENSMUSP00000103217","abundance":10.5,"rank":3988,"name":"Gas2","annotation":"Growth arrest-specific protein 2; May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May play a role in chondrocyte proliferation and differentiation, and in limb myogenesis. May be involved in the regulation of the apoptosis in the interdigital tissues of the developing hindlimb. May be involved in the membrane ruffling process."},{"id":"ENSMUSP00000020454","abundance":10.5,"rank":3989,"name":"Hmg20b","annotation":"High mobility group 20B; Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (By similarity)."},{"id":"ENSMUSP00000102047","abundance":10.5,"rank":3990,"name":"Mrpl38","annotation":"39S ribosomal protein L38, mitochondrial."},{"id":"ENSMUSP00000056855","abundance":10.5,"rank":3991,"name":"Mrps9","annotation":"28S ribosomal protein S9, mitochondrial; Belongs to the universal ribosomal protein uS9 family."},{"id":"ENSMUSP00000095625","abundance":10.5,"rank":3992,"name":"Gm49368","annotation":"Predicted gene, 49368; Belongs to the integrin alpha chain family."},{"id":"ENSMUSP00000047123","abundance":10.5,"rank":3993,"name":"Nop2","annotation":"Probable 28S rRNA (cytosine-C(5))-methyltransferase; Involved in ribosomal large subunit assembly. S-adenosyl-L- methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA. May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation."},{"id":"ENSMUSP00000018544","abundance":10.5,"rank":3994,"name":"Sept4","annotation":"Septin-4; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)."},{"id":"ENSMUSP00000009102","abundance":10.5,"rank":3995,"name":"Vps72","annotation":"Vacuolar protein sorting-associated protein 72 homolog; Deposition-and-exchange histone chaperone specific for H2AZ1, specifically chaperones H2AZ1 and deposits it into nucleosomes. As component of the SRCAP complex, mediates the ATP-dependent exchange of histone H2AZ1/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Belongs to the VPS72/YL1 family."},{"id":"ENSMUSP00000096497","abundance":10.5,"rank":3996,"name":"Defa30","annotation":"Defensin, alpha, 30."},{"id":"ENSMUSP00000006749","abundance":10.5,"rank":3997,"name":"Slc4a1","annotation":"Band 3 anion transport protein; Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride- bicarbonate exch [...] "},{"id":"ENSMUSP00000112277","abundance":10.5,"rank":3998,"name":"Renbp","annotation":"N-acylglucosamine 2-epimerase; Catalyzes the interconversion of N-acetylglucosamine to N- acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway."},{"id":"ENSMUSP00000108099","abundance":10.5,"rank":3999,"name":"Slc4a10","annotation":"Sodium-driven chloride bicarbonate exchanger; Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH. Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride. Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid. Reduces the excitability of CA1 pyramidal neurons and modulates  [...] "},{"id":"ENSMUSP00000143872","abundance":10.5,"rank":4000,"name":"Nrbp1","annotation":"Nuclear receptor-binding protein; May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases."},{"id":"ENSMUSP00000061646","abundance":10.5,"rank":4001,"name":"Crppa","annotation":"D-ribitol-5-phosphate cytidylyltransferase; Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP- ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3- N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By simil [...] "},{"id":"ENSMUSP00000018713","abundance":10.5,"rank":4002,"name":"Cldn7","annotation":"Claudin-7; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity."},{"id":"ENSMUSP00000134825","abundance":10.5,"rank":4003,"name":"Asap1","annotation":"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis (By similarity). Posseses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2."},{"id":"ENSMUSP00000032895","abundance":10.5,"rank":4004,"name":"Nucb2","annotation":"Nucleobindin-2; Calcium-binding protein which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity)."},{"id":"ENSMUSP00000026324","abundance":10.5,"rank":4005,"name":"Acot9","annotation":"Acyl-coenzyme A thioesterase 9, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs."},{"id":"ENSMUSP00000039202","abundance":10.5,"rank":4006,"name":"Aspdh","annotation":"Putative L-aspartate dehydrogenase; Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate."},{"id":"ENSMUSP00000031977","abundance":10.5,"rank":4007,"name":"Agk","annotation":"Acylglycerol kinase, mitochondrial; Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Phosphorylates ceramide but not sphingosine. Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol. Independently of its lipid kinase activity, acts as a component of the TIM22 complex (By similarity). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the me [...] "},{"id":"ENSMUSP00000121504","abundance":10.5,"rank":4008,"name":"Desi1","annotation":"Desumoylating isopeptidase 1; Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity. Desumoylates ZBTB46. Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity); Belongs to the DeSI family."},{"id":"ENSMUSP00000022281","abundance":10.5,"rank":4009,"name":"Mtrex","annotation":"Exosome RNA helicase MTR4; Catalyzes the ATP-dependent unwinding of RNA duplexes with a single-stranded 3' RNA extension. Central subunit of many protein complexes, namely TRAMP-like, nuclear exosome targeting (NEXT) and poly(A) tail exosome targeting (PAXT). NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. PAXT directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental f [...] "},{"id":"ENSMUSP00000005950","abundance":10.5,"rank":4010,"name":"Mmp12","annotation":"Macrophage metalloelastase; May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3 (By similarity). Belongs to the peptidase M10A family."},{"id":"ENSMUSP00000125405","abundance":10.5,"rank":4011,"name":"Stxbp2","annotation":"Syntaxin-binding protein 2; Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells (By similarity)."},{"id":"ENSMUSP00000049861","abundance":10.5,"rank":4012,"name":"AY074887","annotation":"Cleft palate-related protein 1."},{"id":"ENSMUSP00000033826","abundance":10.5,"rank":4013,"name":"Atp4b","annotation":"Potassium-transporting ATPase subunit beta; Required for stabilization and maturation of the catalytic proton pump alpha subunit and may also involved in cell adhesion and establishing epithelial cell polarity; Belongs to the X(+)/potassium ATPases subunit beta family."},{"id":"ENSMUSP00000071985","abundance":10.5,"rank":4014,"name":"Olfr338","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000080403","abundance":10.5,"rank":4015,"name":"Trabd","annotation":"TraB domain-containing protein."},{"id":"ENSMUSP00000091319","abundance":10.4,"rank":4016,"name":"Cep162","annotation":"Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. Localizes to the distal ends of centrioles before ciliogenesis and directly binds to axonemal microtubule, thereby promoting and restricting transition zone formation specifically at the cilia base. Required to mediate CEP290 association with microtubules (By similarity)."},{"id":"ENSMUSP00000081225","abundance":10.4,"rank":4017,"name":"Arhgef10","annotation":"Rho guanine nucleotide exchange factor 10; May play a role in developmental myelination of peripheral nerves."},{"id":"ENSMUSP00000044616","abundance":10.4,"rank":4018,"name":"Wdr44","annotation":"WD repeat-containing protein 44; Downstream effector for RAB11. May be involved in vesicle recycling (By similarity)."},{"id":"ENSMUSP00000094167","abundance":10.4,"rank":4019,"name":"Deptor","annotation":"DEP domain-containing mTOR-interacting protein; Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes (By similarity)."},{"id":"ENSMUSP00000056195","abundance":10.4,"rank":4020,"name":"Suox","annotation":"Sulfite oxidase, mitochondrial."},{"id":"ENSMUSP00000034610","abundance":10.4,"rank":4021,"name":"Pate4","annotation":"Prostate and testis expressed protein 4; Enhances sperm motility. Binds to calmodulin and inhibits calcium transport into spermatozoa. May modulate the function of nicotinic acetylcholine receptors."},{"id":"ENSMUSP00000048803","abundance":10.4,"rank":4022,"name":"Prelp","annotation":"Prolargin; May anchor basement membranes to the underlying connective tissue."},{"id":"ENSMUSP00000006544","abundance":10.4,"rank":4023,"name":"Gcat","annotation":"2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family."},{"id":"ENSMUSP00000031195","abundance":10.4,"rank":4024,"name":"Ugt2a3","annotation":"UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000002445","abundance":10.4,"rank":4025,"name":"Ranbp3","annotation":"Ran-binding protein 3; Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export (By similarity)."},{"id":"ENSMUSP00000031319","abundance":10.4,"rank":4026,"name":"Ppbp","annotation":"Chemokine subfamily B Cys-X-Cys."},{"id":"ENSMUSP00000033626","abundance":10.4,"rank":4027,"name":"Serpina7","annotation":"Thyroxine-binding globulin; Major thyroid hormone transport protein in serum. Belongs to the serpin family."},{"id":"ENSMUSP00000017408","abundance":10.4,"rank":4028,"name":"Exosc10","annotation":"Exosome component 10; Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. [...] "},{"id":"ENSMUSP00000010536","abundance":10.4,"rank":4029,"name":"Gosr1","annotation":"Golgi SNAP receptor complex member 1; Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an import [...] "},{"id":"ENSMUSP00000103947","abundance":10.4,"rank":4030,"name":"Esrp1","annotation":"Epithelial splicing regulatory protein 1; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). Regulates splicing and exp [...] "},{"id":"ENSMUSP00000105751","abundance":10.4,"rank":4031,"name":"Homer3","annotation":"Homer protein homolog 3; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFA [...] "},{"id":"ENSMUSP00000031377","abundance":10.4,"rank":4032,"name":"Scarb2","annotation":"Lysosome membrane protein 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting; Belongs to the CD36 family."},{"id":"ENSMUSP00000032326","abundance":10.4,"rank":4033,"name":"Ddx47","annotation":"Probable ATP-dependent RNA helicase DDX47; Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors (By similarity). Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily."},{"id":"ENSMUSP00000033727","abundance":10.4,"rank":4034,"name":"Ctps2","annotation":"CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity)."},{"id":"ENSMUSP00000022150","abundance":10.4,"rank":4035,"name":"Cartpt","annotation":"Cocaine- and amphetamine-regulated transcript protein; Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus."},{"id":"ENSMUSP00000020493","abundance":10.4,"rank":4036,"name":"Pofut2","annotation":"GDP-fucose protein O-fucosyltransferase 2; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS superfamily and the thrombosporin (TSP) and spondin families. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13 (By similarity). O- fucosylation of TS [...] "},{"id":"ENSMUSP00000140167","abundance":10.4,"rank":4037,"name":"Clasp1","annotation":"CLIP-associating protein 1; Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at le [...] "},{"id":"ENSMUSP00000071769","abundance":10.4,"rank":4038,"name":"Serpinb9e","annotation":"Serine (Or cysteine) peptidase inhibitor, clade B, member 9e; Belongs to the serpin family."},{"id":"ENSMUSP00000033283","abundance":10.4,"rank":4039,"name":"Rrm1","annotation":"Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase large chain family."},{"id":"ENSMUSP00000124066","abundance":10.4,"rank":4040,"name":"Rdh11","annotation":"Retinol dehydrogenase 11; Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9- cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis- retinol (By similarity). Exhibits also reductive activity towards toxic lipid peroxidation products such as medium-chain aldehydes trans-2-nonenal, nonanal, and cis-6-nonenal. Has no dehydrogenase activity towards steroid. Seems to be required for homeostasis of retinol in liver and testis ; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000021832","abundance":10.3,"rank":4041,"name":"Wrnip1","annotation":"ATPase WRNIP1; Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG- I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS."},{"id":"ENSMUSP00000106789","abundance":10.3,"rank":4042,"name":"Akt3","annotation":"RAC-gamma serine/threonine-protein kinase; AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial fo [...] "},{"id":"ENSMUSP00000087680","abundance":10.3,"rank":4043,"name":"Nt5dc2","annotation":"5'-nucleotidase domain-containing 2."},{"id":"ENSMUSP00000133468","abundance":10.3,"rank":4044,"name":"Ptprd","annotation":"Receptor-type tyrosine-protein phosphatase delta; Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically. Involved in pre-synaptic differentiation through interaction with SLITRK2. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily."},{"id":"ENSMUSP00000020268","abundance":10.3,"rank":4045,"name":"Ccar1","annotation":"Cell division cycle and apoptosis regulator protein 1; Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signaling in the presence of the retinoid CD437. Apoptosis induction i [...] "},{"id":"ENSMUSP00000028630","abundance":10.3,"rank":4046,"name":"Slc12a1","annotation":"Solute carrier family 12 member 1; Renal sodium, potassium and chloride ion cotransporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. Electrically silent transporter system."},{"id":"ENSMUSP00000002846","abundance":10.3,"rank":4047,"name":"Gnmt","annotation":"Glycine N-methyltransferase; Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family."},{"id":"ENSMUSP00000027373","abundance":10.3,"rank":4048,"name":"Ppm1f","annotation":"Protein phosphatase 1F; Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis (By similarity)."},{"id":"ENSMUSP00000036245","abundance":10.3,"rank":4049,"name":"Hsd3b7","annotation":"3 beta-hydroxysteroid dehydrogenase type 7; The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymph [...] "},{"id":"ENSMUSP00000021425","abundance":10.3,"rank":4050,"name":"Ahsa1","annotation":"Activator of 90 kDa heat shock protein ATPase homolog 1; Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co- chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (By similarity). Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins."},{"id":"ENSMUSP00000059139","abundance":10.3,"rank":4051,"name":"Vkorc1l1","annotation":"Vitamin K epoxide reductase complex subunit 1-like protein 1; Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins; Belongs to the VKOR family."},{"id":"ENSMUSP00000109612","abundance":10.3,"rank":4052,"name":"Lancl1","annotation":"Glutathione S-transferase LANCL1; Functions as glutathione transferase. Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate. Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism. May play a role in EPS8 signaling. Binds glutathione (By similarity). Belongs to the LanC-like protein family."},{"id":"ENSMUSP00000034815","abundance":10.3,"rank":4053,"name":"Kif23","annotation":"Kinesin-like protein KIF23; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro (By similarity)."},{"id":"ENSMUSP00000033739","abundance":10.3,"rank":4054,"name":"Car5b","annotation":"Carbonic anhydrase 5B, mitochondrial; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family."},{"id":"ENSMUSP00000025851","abundance":10.3,"rank":4055,"name":"Dpp3","annotation":"Dipeptidyl peptidase 3; Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg- beta-naphthylamide (in vitro); Belongs to the peptidase M49 family."},{"id":"ENSMUSP00000028377","abundance":10.3,"rank":4056,"name":"Scn2a","annotation":"Sodium channel protein type 2 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory."},{"id":"ENSMUSP00000103261","abundance":10.3,"rank":4057,"name":"Lrba","annotation":"Lipopolysaccharide-responsive and beige-like anchor protein; May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules."},{"id":"ENSMUSP00000006898","abundance":10.3,"rank":4058,"name":"Gmnn","annotation":"Geminin; Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle."},{"id":"ENSMUSP00000130194","abundance":10.3,"rank":4059,"name":"Slc3a2","annotation":"4F2 cell-surface antigen heavy chain; Component of several heterodimeric amino acid transporter complexes. The precise substrate specificity depends on the other subunit in the heterodimer. The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. The complexes with SLC7A6 and SLC7A7 mediate uptake of dibasic amino acids. The complexes function as amino acid exchangers (By similarity). Required for targeting of SLC7A5 and [...] "},{"id":"ENSMUSP00000060584","abundance":10.3,"rank":4060,"name":"Cyp2c70","annotation":"Cytochrome P450 2C70; A cytochrome P450 monooxygenase involved in muricholic acid (MCA) synthesis. Hydroxylates at the 6-beta position two major bile acids, chenodeoxycholic acid (CDCA) and ursodeoxycholic acid (UDCA) to form alpha-MCA and beta-MCA, respectively. May regulate NR1H4/farnesoid X receptor signaling, as taurine-conjugated MCAs are antagonists of NR1H4. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotei [...] "},{"id":"ENSMUSP00000063104","abundance":10.2,"rank":4061,"name":"Dlk1","annotation":"Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation."},{"id":"ENSMUSP00000019974","abundance":10.2,"rank":4062,"name":"Rab32","annotation":"Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes."},{"id":"ENSMUSP00000126448","abundance":10.2,"rank":4063,"name":"Acot1","annotation":"Acyl-coenzyme A thioesterase 1; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating intracellular levels of acyl-CoAs, free fatty acids and CoASH. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20); Belongs to the C/M/P thioester hydrolase family."},{"id":"ENSMUSP00000030446","abundance":10.2,"rank":4064,"name":"Urod","annotation":"Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III."},{"id":"ENSMUSP00000101148","abundance":10.2,"rank":4065,"name":"Wasf1","annotation":"Wiskott-Aldrich syndrome protein family member 1; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes ; Belongs to the SCAR/WAVE family."},{"id":"ENSMUSP00000032461","abundance":10.2,"rank":4066,"name":"Tamm41","annotation":"Phosphatidate cytidylyltransferase, mitochondrial; Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane; Belongs to the TAM41 family."},{"id":"ENSMUSP00000020991","abundance":10.2,"rank":4067,"name":"Dnmt3a","annotation":"DNA (cytosine-5)-methyltransferase 3A; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimet [...] "},{"id":"ENSMUSP00000023761","abundance":10.2,"rank":4068,"name":"Cox14","annotation":"Cytochrome c oxidase assembly protein COX14; Core component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. Requires for coordination of the early steps of cytochrome c oxidase assembly with the synthesis of MT-CO1."},{"id":"ENSMUSP00000021693","abundance":10.2,"rank":4069,"name":"Slc25a29","annotation":"Mitochondrial basic amino acids transporter; Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter- exchange and uniport mechanisms (By similarity). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 ; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000136869","abundance":10.2,"rank":4070,"name":"Gm5426","annotation":"ATP synthase subunit; Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proto [...] "},{"id":"ENSMUSP00000021381","abundance":10.2,"rank":4071,"name":"Pnn","annotation":"Pinin; Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation [...] "},{"id":"ENSMUSP00000103169","abundance":10.2,"rank":4072,"name":"Med1","annotation":"Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Essential for embryogenes [...] "},{"id":"ENSMUSP00000015596","abundance":10.2,"rank":4073,"name":"Ager","annotation":"Advanced glycosylation end product-specific receptor; Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S1 [...] "},{"id":"ENSMUSP00000038256","abundance":10.2,"rank":4074,"name":"Rbm4b","annotation":"RNA-binding protein 4B; Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA."},{"id":"ENSMUSP00000074899","abundance":10.2,"rank":4075,"name":"Nfia","annotation":"Nuclear factor 1 A-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication; Belongs to the CTF/NF-I family."},{"id":"ENSMUSP00000034458","abundance":10.1,"rank":4076,"name":"Galnt2","annotation":"Polypeptide N-acetylgalactosaminyltransferase 2 soluble form; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region (By similarity); Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily."},{"id":"ENSMUSP00000035303","abundance":10.1,"rank":4077,"name":"Ntmt1","annotation":"N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed; Distributive alpha-N-methyltransferase that methylates the N- terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]- Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif. Some of the substrates may be primed by METTL11B-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly [...] "},{"id":"ENSMUSP00000032994","abundance":10.1,"rank":4078,"name":"Spns1","annotation":"Protein spinster homolog 1; Sphingolipid transporter. May be involved in necrotic or autophagic cell death (By similarity)."},{"id":"ENSMUSP00000001125","abundance":10.1,"rank":4079,"name":"Kctd10","annotation":"BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity)."},{"id":"ENSMUSP00000124047","abundance":10.1,"rank":4080,"name":"Slc30a9","annotation":"Zinc transporter 9; Acts as a zinc transporter involved in intracellular zinc homeostasis (By similarity). Functions as a secondary coactivator for nuclear receptors by cooperating with p160 coactivators subtypes. Plays a role in transcriptional activation of Wnt- responsive genes ; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily."},{"id":"ENSMUSP00000030143","abundance":10.1,"rank":4081,"name":"Ubap2","annotation":"Ubiquitin-associated protein 2."},{"id":"ENSMUSP00000099390","abundance":10.1,"rank":4082,"name":"Pigt","annotation":"GPI transamidase component PIG-T; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates (By similarity)."},{"id":"ENSMUSP00000027062","abundance":10.1,"rank":4083,"name":"Msc","annotation":"Musculin; Transcription repressor that blocks myogenesis and activation of E-box dependent muscle genes."},{"id":"ENSMUSP00000106055","abundance":10.1,"rank":4084,"name":"Gabpb1","annotation":"GA-binding protein subunit beta-1; Transcription factor capable of interacting with purine rich repeats (GA repeats). Acts as a a master regulator of nuclear-encoded mitochondrial genes."},{"id":"ENSMUSP00000093980","abundance":10.1,"rank":4085,"name":"Polr2g","annotation":"DNA-directed RNA polymerase II subunit RPB7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems  [...] "},{"id":"ENSMUSP00000050461","abundance":10.1,"rank":4086,"name":"Rbm12","annotation":"RNA-binding protein 12."},{"id":"ENSMUSP00000040779","abundance":10.1,"rank":4087,"name":"Ttc1","annotation":"Tetratricopeptide repeat protein 1."},{"id":"ENSMUSP00000027339","abundance":10.1,"rank":4088,"name":"Smap1","annotation":"Stromal membrane-associated protein 1; GTPase activating protein that acts on ARF6. Plays a role in clathrin-dependent endocytosis. May play a role in erythropoiesis."},{"id":"ENSMUSP00000024958","abundance":10.1,"rank":4089,"name":"Caskin1","annotation":"Caskin-1; May link the scaffolding protein CASK to downstream intracellular effectors."},{"id":"ENSMUSP00000087950","abundance":10.1,"rank":4090,"name":"Cdc14a","annotation":"Dual specificity protein phosphatase CDC14A; Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis (By similarity). Required for normal hearing."},{"id":"ENSMUSP00000106278","abundance":10.1,"rank":4091,"name":"Trp53bp1","annotation":"TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)- mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs s [...] "},{"id":"ENSMUSP00000128292","abundance":10.1,"rank":4092,"name":"Pum2","annotation":"Pumilio homolog 2; Sequence-specific RNA-binding protein that acts as a post- transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'- UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Acts as a post-tr [...] "},{"id":"ENSMUSP00000074875","abundance":10.1,"rank":4093,"name":"Mettl7a3","annotation":"Methyltransferase-like 7A3."},{"id":"ENSMUSP00000113052","abundance":10,"rank":4094,"name":"Adal","annotation":"Adenosine deaminase-like protein; Catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotide N(6)-methyl-AMP (N6-mAMP) to produce inositol monophosphate (IMP) and methylamine. Is required for the catabolism of cytosolic N6-mAMP, which is derived from the degradation of mRNA containing N6-methylated adenine (m6A)."},{"id":"ENSMUSP00000097393","abundance":10,"rank":4095,"name":"Prl2c3","annotation":"Prolactin-2C3; May have a role in embryonic development. It is likely to provide a growth stimulus to target cells in maternal and fetal tissues during the development of the embryo at mid-gestation. May play a role during wound healing and in the hair follicle cycle as a growth factor and/or an angiogenesis factor. May play a role in microvilli formation and cell proliferation of neuroblastoma cells."},{"id":"ENSMUSP00000103042","abundance":10,"rank":4096,"name":"Krt32","annotation":"Keratin, type I cuticular Ha2; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000105754","abundance":10,"rank":4097,"name":"Slc25a42","annotation":"Mitochondrial coenzyme A transporter SLC25A42; Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate."},{"id":"ENSMUSP00000043442","abundance":10,"rank":4098,"name":"Ccdc93","annotation":"Coiled-coil domain-containing protein 93; Component of the CCC complex, which is involved in the regulation of endosomal recycling of surface proteins, including integrins, signaling receptor and channels. The CCC complex associates with SNX17, retriever and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGA5:ITGB1. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and coop [...] "},{"id":"ENSMUSP00000080743","abundance":10,"rank":4099,"name":"Ptcd3","annotation":"Pentatricopeptide repeat domain-containing protein 3, mitochondrial; Mitochondrial RNA-binding protein that has a role in mitochondrial translation."},{"id":"ENSMUSP00000040342","abundance":10,"rank":4100,"name":"Pcsk1n","annotation":"Big PEN-LEN; May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing o [...] "},{"id":"ENSMUSP00000048573","abundance":10,"rank":4101,"name":"Agpat1","annotation":"1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone."},{"id":"ENSMUSP00000101630","abundance":10,"rank":4102,"name":"Gatd1","annotation":"Glutamine amidotransferase-like class 1 domain-containing protein 1."},{"id":"ENSMUSP00000027781","abundance":9.98,"rank":4103,"name":"Cox20","annotation":"Cytochrome c oxidase assembly protein COX20, mitochondrial; Essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Acts as a chaperone in the early steps of cytochrome c oxidase subunit II (MT- CO2/COX2) maturation, stabilizing the newly synthesized protein and presenting it to metallochaperones SCO1/2 which in turn facilitates the incorporation of the mature MT-CO2/COX2 into the assembling CIV holoenzyme."},{"id":"ENSMUSP00000025891","abundance":9.98,"rank":4104,"name":"Capn1","annotation":"Calpain-1 catalytic subunit; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction."},{"id":"ENSMUSP00000081575","abundance":9.98,"rank":4105,"name":"Fkbp15","annotation":"FK506-binding protein 15; Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-based movement (By similarity). May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase."},{"id":"ENSMUSP00000111023","abundance":9.98,"rank":4106,"name":"Slc12a2","annotation":"Solute carrier family 12 member 2; Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume; Belongs to the SLC12A transporter family."},{"id":"ENSMUSP00000105883","abundance":9.97,"rank":4107,"name":"Ltbp2","annotation":"Latent-transforming growth factor beta-binding protein 2; May play an integral structural role in elastic-fiber architectural organization and/or assembly. Belongs to the LTBP family."},{"id":"ENSMUSP00000032179","abundance":9.97,"rank":4108,"name":"Nup210","annotation":"Nuclear pore membrane glycoprotein 210; Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity; Belongs to the NUP210 family."},{"id":"ENSMUSP00000005003","abundance":9.97,"rank":4109,"name":"Lbr","annotation":"Delta(14)-sterol reductase LBR; Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis. Plays a critical role in myeloid cell cholesterol biosynthesis which is essential to both myeloid cell growth and functional maturation. Mediates the activation of NADPH oxidases, perhaps by maintaining critical levels of cholesterol required for membrane lipid raft formation during neutrophil differentiation. Anchors the lamina and the heterochromatin to the inner nuclear membrane (By similarity)."},{"id":"ENSMUSP00000033505","abundance":9.97,"rank":4110,"name":"Was","annotation":"Wiskott-Aldrich syndrome protein homolog; Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombinatio [...] "},{"id":"ENSMUSP00000000299","abundance":9.95,"rank":4111,"name":"Itgb2","annotation":"Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (By similarity). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITG [...] "},{"id":"ENSMUSP00000153313","abundance":9.95,"rank":4112,"name":"Sorbs1","annotation":"Sorbin and SH3 domain-containing protein 1."},{"id":"ENSMUSP00000001183","abundance":9.94,"rank":4113,"name":"Ftcd","annotation":"Formimidoyltetrahydrofolate cyclodeaminase; Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool (By similarity); In the N-terminal section; belongs to the formiminotransferase family."},{"id":"ENSMUSP00000099681","abundance":9.94,"rank":4114,"name":"Stxbp3","annotation":"Syntaxin-binding protein 3; Together with STX4 and VAMP2, may play a role in insulin- dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes."},{"id":"ENSMUSP00000026976","abundance":9.94,"rank":4115,"name":"Get4","annotation":"Golgi to ER traffic protein 4 homolog; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of  [...] "},{"id":"ENSMUSP00000033983","abundance":9.94,"rank":4116,"name":"Mak16","annotation":"Protein MAK16 homolog."},{"id":"ENSMUSP00000113705","abundance":9.94,"rank":4117,"name":"Dmxl2","annotation":"DmX-like protein 2; May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles of neuronal and endocrine homeostatic processes (By similarity). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes."},{"id":"ENSMUSP00000035194","abundance":9.93,"rank":4118,"name":"Mapkapk3","annotation":"MAP kinase-activated protein kinase 3; Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to [...] "},{"id":"ENSMUSP00000057731","abundance":9.92,"rank":4119,"name":"Nelfb","annotation":"Negative elongation factor B; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (Pol II). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity). May be able to induce chromatin unfolding (By similarity). Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes. Pl [...] "},{"id":"ENSMUSP00000050430","abundance":9.92,"rank":4120,"name":"Myct1","annotation":"Myc target protein 1; May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability and inhibition of hematopoietic differentiation. Belongs to the MYCT1 family."},{"id":"ENSMUSP00000151553","abundance":9.91,"rank":4121,"name":"Apon","annotation":"Apolipoprotein N."},{"id":"ENSMUSP00000001319","abundance":9.9,"rank":4122,"name":"Efnb2","annotation":"Ephrin-B2; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 an [...] "},{"id":"ENSMUSP00000044405","abundance":9.9,"rank":4123,"name":"Fmo2","annotation":"Dimethylaniline monooxygenase [N-oxide-forming] 2; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Shows catalytic activity towards methimazole, thiourea, trimethylamine, and the insecticide phorate; Belongs to the FMO family."},{"id":"ENSMUSP00000025590","abundance":9.88,"rank":4124,"name":"Osbp","annotation":"Oxysterol-binding protein 1; Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25- hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol  [...] "},{"id":"ENSMUSP00000062476","abundance":9.88,"rank":4125,"name":"Mrpl50","annotation":"39S ribosomal protein L50, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL50 family."},{"id":"ENSMUSP00000102852","abundance":9.88,"rank":4126,"name":"Pip5k1a","annotation":"Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5- trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4- phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organ [...] "},{"id":"ENSMUSP00000103166","abundance":9.87,"rank":4127,"name":"Bglap3","annotation":"Osteocalcin-related protein; Binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family."},{"id":"ENSMUSP00000131817","abundance":9.87,"rank":4128,"name":"9430015G10Rik","annotation":"RIKEN cDNA 9430015G10 gene."},{"id":"ENSMUSP00000087202","abundance":9.87,"rank":4129,"name":"Trappc9","annotation":"Trafficking protein particle complex subunit 9; Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi."},{"id":"ENSMUSP00000020217","abundance":9.85,"rank":4130,"name":"Nudt4","annotation":"Diphosphoinositol polyphosphate phosphohydrolase 2; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), PP-InsP4 and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphate Ap6A, but not Ap5A. The major reaction products are ADP and p4a from Ap6A. Also able to hydrolyze 5- phosphoribose 1-diphosphate (By similarity). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. Belongs to the Nudix hyd [...] "},{"id":"ENSMUSP00000031002","abundance":9.85,"rank":4131,"name":"Man2b2","annotation":"Epididymis-specific alpha-mannosidase; Plays an important role in the early step of spermatogenesis; Belongs to the glycosyl hydrolase 38 family."},{"id":"ENSMUSP00000152784","abundance":9.85,"rank":4132,"name":"Ccnk","annotation":"Cyclin-K; Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A)."},{"id":"ENSMUSP00000065084","abundance":9.84,"rank":4133,"name":"Sec14l3","annotation":"SEC14-like 3 (S. cerevisiae)."},{"id":"ENSMUSP00000055225","abundance":9.84,"rank":4134,"name":"Kcna1","annotation":"Potassium voltage-gated channel subfamily A member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the kidney. Contributes to the regulation of the membrane potential and nerve signaling, and prevents neuronal hyperexcitability. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference acros [...] "},{"id":"ENSMUSP00000083242","abundance":9.82,"rank":4135,"name":"Scarb1","annotation":"Scavenger receptor class B member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (By similarity). Both isoform 1 and isoform 2 act as receptors for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux. Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine bindin [...] "},{"id":"ENSMUSP00000099545","abundance":9.8,"rank":4136,"name":"Szrd1","annotation":"SUZ domain-containing protein 1."},{"id":"ENSMUSP00000020171","abundance":9.79,"rank":4137,"name":"Ccn2","annotation":"CCN family member 2; Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation- dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity)."},{"id":"ENSMUSP00000005067","abundance":9.79,"rank":4138,"name":"Sgta","annotation":"Small glutamine-rich tetratricopeptide repeat-containing protein alpha; Co-chaperone that binds misfolded and hydrophobic patches- containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in [...] "},{"id":"ENSMUSP00000020490","abundance":9.79,"rank":4139,"name":"Wdr82","annotation":"WD repeat-containing protein 82; Regulatory component of the SET1 complex implicated in the tethering of this complex to transcriptional start sites of active genes. Facilitates histone H3 'Lys-4' methylation via recruitment of the SETD1A or SETD1B to the 'Ser-5' phosphorylated C-terminal domain (CTD) of RNA polymerase II large subunit (POLR2A). Component of PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Possible role in telomere length maintenance and in mRNA processin [...] "},{"id":"ENSMUSP00000125760","abundance":9.78,"rank":4140,"name":"Crb3","annotation":"Protein crumbs homolog 3; Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions (By similarity)."},{"id":"ENSMUSP00000099551","abundance":9.77,"rank":4141,"name":"Coro6","annotation":"Coronin-6."},{"id":"ENSMUSP00000031598","abundance":9.77,"rank":4142,"name":"Ddx54","annotation":"ATP-dependent RNA helicase DDX54; Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (By similarity). Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily."},{"id":"ENSMUSP00000077877","abundance":9.76,"rank":4143,"name":"1700084M14Rik","annotation":"RIKEN cDNA 1700084M14 gene."},{"id":"ENSMUSP00000004200","abundance":9.75,"rank":4144,"name":"Cwc15","annotation":"Spliceosome-associated protein CWC15 homolog; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing."},{"id":"ENSMUSP00000078661","abundance":9.75,"rank":4145,"name":"Hax1","annotation":"HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools; Belongs to the HAX1 family."},{"id":"ENSMUSP00000023359","abundance":9.74,"rank":4146,"name":"Nde1","annotation":"Nuclear distribution protein nudE homolog 1; Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neurona [...] "},{"id":"ENSMUSP00000053270","abundance":9.74,"rank":4147,"name":"Lipa","annotation":"Lysosomal acid lipase/cholesteryl ester hydrolase; Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation (By similarity); Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000120925","abundance":9.74,"rank":4148,"name":"Zbtb8os","annotation":"Protein archease; Component of the tRNA-splicing ligase complex required to facilitate the enzymatic turnover of catalytic subunit RTCB. Together with DDX1, acts by facilitating the guanylylation of RTCB, a key intermediate step in tRNA ligation (By similarity); Belongs to the archease family."},{"id":"ENSMUSP00000030069","abundance":9.73,"rank":4149,"name":"Ptgr1","annotation":"Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Has no activity towards PGE1, PGE2 and PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4 (By similarity)."},{"id":"ENSMUSP00000050716","abundance":9.72,"rank":4150,"name":"Efnb1","annotation":"Ephrin-B1 intracellular domain; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binding to Eph receptors residing on adjacent cells leads to contact-dependent bidirectional signaling into neighboring cells. Shows high affinity for the receptor tyrosine kinase EPHB1/ELK (By similarity). Can also bind EPHB2 and EPHB3. Binds to, and induces the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orien [...] "},{"id":"ENSMUSP00000116393","abundance":9.72,"rank":4151,"name":"Gm37240","annotation":"Predicted gene, 37240."},{"id":"ENSMUSP00000033749","abundance":9.72,"rank":4152,"name":"Pir","annotation":"Pirin; Transcriptional coregulator of NF-kappa-B which facilitates binding of NF-kappa-B proteins to target kappa-B genes in a redox- state-dependent manner. May be required for efficient terminal myeloid maturation of hematopoietic cells. Has quercetin 2,3-dioxygenase activity (in vitro) (By similarity); Belongs to the pirin family."},{"id":"ENSMUSP00000106224","abundance":9.72,"rank":4153,"name":"Prl2c2","annotation":"Prolactin-2C2; May have a role in embryonic development. It is likely to provide a growth stimulus to target cells in maternal and fetal tissues during the development of the embryo at mid-gestation. May play a role during wound healing and in the hair follicle cycle as a growth factor and/or an angiogenesis factor. May play a role in microvilli formation and cell proliferation of neuroblastoma cells. Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000041380","abundance":9.72,"rank":4154,"name":"Chchd4","annotation":"Mitochondrial intermembrane space import and assembly protein 40; Central component of a redox-sensitive mitochondrial intermembrane space import machinery which is required for the biogenesis of respiratory chain complexes. Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17, COX19, MICU1 and COA7. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Required for the import of COA7 in the IMS. Precursor proteins to be imported into the IMS are translo [...] "},{"id":"ENSMUSP00000044004","abundance":9.71,"rank":4155,"name":"Lrp1","annotation":"Low-density lipoprotein receptor-related protein 1 intracellular domain; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotra [...] "},{"id":"ENSMUSP00000115228","abundance":9.69,"rank":4156,"name":"Phactr1","annotation":"Phosphatase and actin regulator 1; Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization."},{"id":"ENSMUSP00000041447","abundance":9.69,"rank":4157,"name":"Pdk2","annotation":"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial; Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular  [...] "},{"id":"ENSMUSP00000106117","abundance":9.69,"rank":4158,"name":"Gpx5","annotation":"Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids."},{"id":"ENSMUSP00000037194","abundance":9.69,"rank":4159,"name":"Scai","annotation":"Protein SCAI; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1."},{"id":"ENSMUSP00000158887","abundance":9.68,"rank":4160,"name":"Cyp2c40","annotation":"Cytochrome P450 2C40; A cytochrome P450 monooxygenase that may play a major role in the metabolism of arachidonic acid in the intestinal tract. Exhibits regioselective hydroxylase and epoxidase activity toward arachidonic acid, producing 16(R)- hydroxyeicosatetraenoic acid (HETE) and (14R,15S)-epoxyeicosatrienoic acid (EpETrE) as major products. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)."},{"id":"ENSMUSP00000099984","abundance":9.68,"rank":4161,"name":"Gck","annotation":"Hexokinase-4; Catalyzes the phosphorylation of hexose, such as D-glucose, D-fructose and D-mannose, to hexose 6-phosphate (D-glucose 6-phosphate, D-fructose 6-phosphate and D-mannose 6-phosphate, respectively). Compared to other hexokinases, has a weak affinity for D-glucose, and is effective only when glucose is abundant (By similarity). Mainly expressed in pancreatic beta cells and the liver and constitutes a rate-limiting step in glucose metabolism in these tissues. Since insulin secretion parallels glucose metabolism and the low glucose affinity of GCK ensures that it can change it [...] "},{"id":"ENSMUSP00000001258","abundance":9.68,"rank":4162,"name":"Uhrf1","annotation":"E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] "},{"id":"ENSMUSP00000128705","abundance":9.68,"rank":4163,"name":"Tmem176b","annotation":"Transmembrane protein 176B; May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells."},{"id":"ENSMUSP00000024866","abundance":9.66,"rank":4164,"name":"Xdh","annotation":"Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species."},{"id":"ENSMUSP00000042187","abundance":9.66,"rank":4165,"name":"Smpd1","annotation":"Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2- diacylglycerolphosphoglycerol; Belongs to the acid sphingomyelinase family."},{"id":"ENSMUSP00000018691","abundance":9.66,"rank":4166,"name":"Pip4k2b","annotation":"Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate."},{"id":"ENSMUSP00000020008","abundance":9.66,"rank":4167,"name":"Gopc","annotation":"Golgi-associated PDZ and coiled-coil motif-containing protein; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes."},{"id":"ENSMUSP00000015160","abundance":9.66,"rank":4168,"name":"Acsf3","annotation":"Malonate--CoA ligase ACSF3, mitochondrial; Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates."},{"id":"ENSMUSP00000026243","abundance":9.66,"rank":4169,"name":"Oga","annotation":"Protein O-GlcNAcase; Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha- GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity."},{"id":"ENSMUSP00000055470","abundance":9.65,"rank":4170,"name":"Taok1","annotation":"Serine/threonine-protein kinase TAO1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK1 [...] "},{"id":"ENSMUSP00000038732","abundance":9.65,"rank":4171,"name":"Qpct","annotation":"Glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N- terminal glutaminyl residue and a lack of importance of chain length after the second residue (By similarity)."},{"id":"ENSMUSP00000018755","abundance":9.64,"rank":4172,"name":"Pdlim4","annotation":"PDZ and LIM domain protein 4; Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transpo [...] "},{"id":"ENSMUSP00000114006","abundance":9.64,"rank":4173,"name":"Golim4","annotation":"Golgi integral membrane protein 4; Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi; Belongs to the GOLIM4 family."},{"id":"ENSMUSP00000030432","abundance":9.64,"rank":4174,"name":"Hmgcl","annotation":"Hydroxymethylglutaryl-CoA lyase, mitochondrial; Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism."},{"id":"ENSMUSP00000065409","abundance":9.64,"rank":4175,"name":"Tmem9","annotation":"Transmembrane protein 9; May be involved in intracellular transport; Belongs to the TMEM9 family."},{"id":"ENSMUSP00000030367","abundance":9.64,"rank":4176,"name":"Ssbp3","annotation":"Single-stranded DNA-binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region."},{"id":"ENSMUSP00000099470","abundance":9.63,"rank":4177,"name":"Cds2","annotation":"Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin; Belongs to the CDS family."},{"id":"ENSMUSP00000033018","abundance":9.63,"rank":4178,"name":"Far1","annotation":"Fatty acyl-CoA reductase 1; Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols (By similarity). In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis."},{"id":"ENSMUSP00000118564","abundance":9.63,"rank":4179,"name":"Gm20388","annotation":"Predicted gene 20388."},{"id":"ENSMUSP00000099038","abundance":9.63,"rank":4180,"name":"Cbll1","annotation":"E3 ubiquitin-protein ligase Hakai; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown. Belongs to the Hakai family."},{"id":"ENSMUSP00000110250","abundance":9.62,"rank":4181,"name":"Eif2b4","annotation":"Translation initiation factor eIF-2B subunit delta; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP."},{"id":"ENSMUSP00000024959","abundance":9.62,"rank":4182,"name":"Cript","annotation":"Cysteine-rich PDZ-binding protein; Involved in the cytoskeletal anchoring of DLG4 in excitatory synapses."},{"id":"ENSMUSP00000106480","abundance":9.62,"rank":4183,"name":"Lpgat1","annotation":"Acyl-CoA:lysophosphatidylglycerol acyltransferase 1; Lysophosphatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl- CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor (By similarity)."},{"id":"ENSMUSP00000044050","abundance":9.62,"rank":4184,"name":"Dpp4","annotation":"Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] "},{"id":"ENSMUSP00000116627","abundance":9.61,"rank":4185,"name":"Adhfe1","annotation":"Hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity)."},{"id":"ENSMUSP00000058490","abundance":9.61,"rank":4186,"name":"Hoxd9","annotation":"Homeobox protein Hox-D9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis."},{"id":"ENSMUSP00000113441","abundance":9.6,"rank":4187,"name":"Dpp6","annotation":"Dipeptidyl aminopeptidase-like protein 6; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity (By similarity). Belongs to the peptidase S9B family."},{"id":"ENSMUSP00000025570","abundance":9.6,"rank":4188,"name":"Sdhaf2","annotation":"Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer; Belongs to the SDHAF2 family."},{"id":"ENSMUSP00000025893","abundance":9.59,"rank":4189,"name":"Arl2","annotation":"ADP-ribosylation factor-like protein 2; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the ef [...] "},{"id":"ENSMUSP00000125583","abundance":9.59,"rank":4190,"name":"Armc2","annotation":"Armadillo repeat-containing protein 2; Required for sperm flagellum axoneme organization and function. Involved in axonemal central pair complex assembly and/or stability."},{"id":"ENSMUSP00000027554","abundance":9.59,"rank":4191,"name":"Cln8","annotation":"Protein CLN8; Could play a role in cell proliferation during neuronal differentiation and in protection against cell death."},{"id":"ENSMUSP00000019050","abundance":9.58,"rank":4192,"name":"P4ha2","annotation":"Prolyl 4-hydroxylase subunit alpha-2; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins."},{"id":"ENSMUSP00000055016","abundance":9.57,"rank":4193,"name":"Usp48","annotation":"Ubiquitin carboxyl-terminal hydrolase 48; Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites (By similarity)."},{"id":"ENSMUSP00000108819","abundance":9.56,"rank":4194,"name":"Armcx6","annotation":"Protein ARMCX6; May regulate the dynamics and distribution of mitochondria in neural cells."},{"id":"ENSMUSP00000124782","abundance":9.56,"rank":4195,"name":"Pip4p1","annotation":"Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrog [...] "},{"id":"ENSMUSP00000130738","abundance":9.55,"rank":4196,"name":"Cul3","annotation":"Cullin-3; Core component of multiple cullin-RING-based BCR (BTB-CUL3- RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). BCR complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (By similarity). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (By similarity). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhi [...] "},{"id":"ENSMUSP00000127604","abundance":9.55,"rank":4197,"name":"Itgb4","annotation":"Integrin beta-4; Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling."},{"id":"ENSMUSP00000076227","abundance":9.53,"rank":4198,"name":"Rabac1","annotation":"Prenylated Rab acceptor protein 1; General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI1 (By similarity); Belongs to the PRA1 family."},{"id":"ENSMUSP00000061493","abundance":9.52,"rank":4199,"name":"Eea1","annotation":"Early endosome antigen 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking."},{"id":"ENSMUSP00000132007","abundance":9.52,"rank":4200,"name":"Cypt2","annotation":"Cysteine-rich perinuclear theca 2."},{"id":"ENSMUSP00000109523","abundance":9.52,"rank":4201,"name":"Gspt2","annotation":"Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity)."},{"id":"ENSMUSP00000092966","abundance":9.51,"rank":4202,"name":"Cyp4v3","annotation":"Cytochrome P450 4V2; Omega-hydroxylase that oxidizes medium-chain saturated fatty acids and polyunsaturated omega-3 fatty acids, and which plays a role in fatty acid and steroid metabolism in the eye. Catalyzes the omega- hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). Acts as a polyunsaturated omega-3 fatty acids hydroxylase by mediating oxidation of docosahexaenoate (DHA) to 22- hydroxydocosahexaenoate. Also produces some 2 [...] "},{"id":"ENSMUSP00000033158","abundance":9.5,"rank":4203,"name":"Ubfd1","annotation":"Ubiquitin domain-containing protein UBFD1."},{"id":"ENSMUSP00000031594","abundance":9.5,"rank":4204,"name":"Sdsl","annotation":"Serine dehydratase-like; Has low serine dehydratase and threonine dehydratase activity; Belongs to the serine/threonine dehydratase family."},{"id":"ENSMUSP00000056621","abundance":9.5,"rank":4205,"name":"Lcp2","annotation":"Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling."},{"id":"ENSMUSP00000064479","abundance":9.5,"rank":4206,"name":"Wfdc21","annotation":"Protein Wfdc21; May promote activation of the metalloproteinase MMP2."},{"id":"ENSMUSP00000137345","abundance":9.49,"rank":4207,"name":"Rbm4","annotation":"RNA-binding protein 4; RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation [...] "},{"id":"ENSMUSP00000021667","abundance":9.49,"rank":4208,"name":"Isca2","annotation":"Iron-sulfur cluster assembly 2 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. Belongs to the HesB/IscA family."},{"id":"ENSMUSP00000032476","abundance":9.49,"rank":4209,"name":"Slc2a3","annotation":"Solute carrier family 2, facilitated glucose transporter member 3; Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport."},{"id":"ENSMUSP00000102853","abundance":9.49,"rank":4210,"name":"Eed","annotation":"Polycomb protein EED; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby [...] "},{"id":"ENSMUSP00000036998","abundance":9.48,"rank":4211,"name":"Lnpep","annotation":"Leucyl-cystinyl aminopeptidase; Release of an N-terminal amino acid, cleave before cysteine, leucine as well as other amino acids. Degrades peptide hormones such as oxytocin, vasopressin and angiotensin III, and plays a role in maintaining homeostasis during pregnancy. May be involved in the inactivation of neuronal peptides in the brain. Cleaves Met-enkephalin and dynorphin. Binds angiotensin IV and may be the angiotensin IV receptor in the brain (By similarity)."},{"id":"ENSMUSP00000115024","abundance":9.47,"rank":4212,"name":"Prl2c5","annotation":"Prolactin-2C5."},{"id":"ENSMUSP00000109628","abundance":9.47,"rank":4213,"name":"Rpe","annotation":"Ribulose-phosphate 3-epimerase; Catalyzes the reversible epimerization of D-ribulose 5- phosphate to D-xylulose 5-phosphate."},{"id":"ENSMUSP00000039910","abundance":9.47,"rank":4214,"name":"C030006K11Rik","annotation":"UPF0598 protein C8orf82 homolog; Belongs to the UPF0598 family."},{"id":"ENSMUSP00000139531","abundance":9.46,"rank":4215,"name":"Twist2","annotation":"Twist-related protein 2; Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity)."},{"id":"ENSMUSP00000080597","abundance":9.46,"rank":4216,"name":"Serpinb9g","annotation":"Serine (Or cysteine) peptidase inhibitor, clade B, member 9g; Belongs to the serpin family."},{"id":"ENSMUSP00000037536","abundance":9.46,"rank":4217,"name":"Ltbp4","annotation":"Latent-transforming growth factor beta-binding protein 4; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta."},{"id":"ENSMUSP00000123325","abundance":9.46,"rank":4218,"name":"Rab9","annotation":"Ras-related protein Rab-9A; Involved in the transport of proteins between the endosomes and the trans-Golgi network (By similarity). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000140274","abundance":9.44,"rank":4219,"name":"Abi2","annotation":"Abl interactor 2; Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (By similarity). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (By similarity). Contributes to the regulation of act [...] "},{"id":"ENSMUSP00000031412","abundance":9.43,"rank":4220,"name":"Acad10","annotation":"Acyl-CoA dehydrogenase family member 10; Acyl-CoA dehydrogenase only active with R- and S-2-methyl- C15-CoA."},{"id":"ENSMUSP00000033715","abundance":9.42,"rank":4221,"name":"Nsdhl","annotation":"Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis."},{"id":"ENSMUSP00000028361","abundance":9.42,"rank":4222,"name":"Il1f6","annotation":"Interleukin-36 alpha; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL- 36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and ce [...] "},{"id":"ENSMUSP00000027370","abundance":9.41,"rank":4223,"name":"Pnkd","annotation":"Probable hydrolase PNKD; Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway."},{"id":"ENSMUSP00000036761","abundance":9.41,"rank":4224,"name":"En2","annotation":"Homeobox protein engrailed-2."},{"id":"ENSMUSP00000051830","abundance":9.41,"rank":4225,"name":"Dnmt3b","annotation":"DNA (cytosine-5)-methyltransferase 3B; Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dime [...] "},{"id":"ENSMUSP00000103162","abundance":9.4,"rank":4226,"name":"Cdk12","annotation":"Cyclin-dependent kinase 12; Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading [...] "},{"id":"ENSMUSP00000033582","abundance":9.4,"rank":4227,"name":"Cox7b","annotation":"Cytochrome c oxidase subunit 7B, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] "},{"id":"ENSMUSP00000021078","abundance":9.39,"rank":4228,"name":"Fdxr","annotation":"NADPH:adrenodoxin oxidoreductase, mitochondrial; Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C- 27 hydroxylation in the liver."},{"id":"ENSMUSP00000018803","abundance":9.38,"rank":4229,"name":"Pnpo","annotation":"Pyridoxine-5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)."},{"id":"ENSMUSP00000033992","abundance":9.38,"rank":4230,"name":"Gsr","annotation":"Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol."},{"id":"ENSMUSP00000113928","abundance":9.38,"rank":4231,"name":"Anapc7","annotation":"Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)."},{"id":"ENSMUSP00000083611","abundance":9.37,"rank":4232,"name":"Nck2","annotation":"Cytoplasmic protein NCK2; Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling (By similarity)."},{"id":"ENSMUSP00000105501","abundance":9.37,"rank":4233,"name":"Snph","annotation":"Syntaphilin; Inhibits SNARE complex formation by absorbing free syntaxin- 1."},{"id":"ENSMUSP00000002640","abundance":9.36,"rank":4234,"name":"Scin","annotation":"Adseverin; Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis- phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskel [...] "},{"id":"ENSMUSP00000019708","abundance":9.35,"rank":4235,"name":"Arid3a","annotation":"AT-rich interactive domain-containing protein 3A; Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway."},{"id":"ENSMUSP00000096899","abundance":9.35,"rank":4236,"name":"Bfsp1","annotation":"Filensin C-terminal fragment; Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). Involved in altering the calcium regulation of MIP water permeability (By similarity)."},{"id":"ENSMUSP00000017597","abundance":9.34,"rank":4237,"name":"Pipox","annotation":"Peroxisomal sarcosine oxidase; Metabolizes sarcosine, L-pipecolic acid and L-proline."},{"id":"ENSMUSP00000034377","abundance":9.34,"rank":4238,"name":"Pla2g15","annotation":"Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen."},{"id":"ENSMUSP00000022553","abundance":9.34,"rank":4239,"name":"Cab39l","annotation":"Calcium-binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity)."},{"id":"ENSMUSP00000109779","abundance":9.34,"rank":4240,"name":"Fam3a","annotation":"Protein FAM3A."},{"id":"ENSMUSP00000140159","abundance":9.33,"rank":4241,"name":"Gstp3","annotation":"Glutathione S-transferase pi 3."},{"id":"ENSMUSP00000054734","abundance":9.33,"rank":4242,"name":"Zc2hc1a","annotation":"Zinc finger C2HC domain-containing protein 1A."},{"id":"ENSMUSP00000125609","abundance":9.33,"rank":4243,"name":"Gm28048","annotation":"COMM domain-containing 1B."},{"id":"ENSMUSP00000006911","abundance":9.33,"rank":4244,"name":"Cdk4","annotation":"Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] "},{"id":"ENSMUSP00000075990","abundance":9.33,"rank":4245,"name":"Sypl","annotation":"Synaptophysin-like protein 1."},{"id":"ENSMUSP00000020270","abundance":9.32,"rank":4246,"name":"Ddx50","annotation":"ATP-dependent RNA helicase DDX50."},{"id":"ENSMUSP00000104892","abundance":9.32,"rank":4247,"name":"Zmynd8","annotation":"Zinc finger, MYND-type-containing 8."},{"id":"ENSMUSP00000033095","abundance":9.31,"rank":4248,"name":"Prr14","annotation":"Proline-rich protein 14; Functions in tethering peripheral heterochromatin to the nuclear lamina during interphase, possibly through the interaction with heterochromatin protein CBX5/HP1 alpha (By similarity). Might play a role in reattaching heterochromatin to the nuclear lamina at mitotic exit (By similarity). Promotes myoblast differentiation during skeletal myogenesis, possibly by stimulating transcription factor MyoD activity via binding to CBX5/HP1 alpha  (By similarity). Involved in the positive regulation of the PI3K-Akt-mTOR signaling pathway and in promoting cell proliferatio [...] "},{"id":"ENSMUSP00000105922","abundance":9.31,"rank":4249,"name":"Serpinb6b","annotation":"Serine (Or cysteine) peptidase inhibitor, clade B, member 6B; Belongs to the serpin family."},{"id":"ENSMUSP00000119841","abundance":9.3,"rank":4250,"name":"Lsm6","annotation":"U6 snRNA-associated Sm-like protein LSm6; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is tho [...] "},{"id":"ENSMUSP00000035010","abundance":9.3,"rank":4251,"name":"Stt3b","annotation":"Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] "},{"id":"ENSMUSP00000039586","abundance":9.3,"rank":4252,"name":"Serpine1","annotation":"Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (B [...] "},{"id":"ENSMUSP00000106359","abundance":9.29,"rank":4253,"name":"Kdelr2","annotation":"ER lumen protein-retaining receptor 2; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (By similarity). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity)."},{"id":"ENSMUSP00000029812","abundance":9.29,"rank":4254,"name":"Nfkb1","annotation":"Nuclear factor NF-kappa-B p105 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dime [...] "},{"id":"ENSMUSP00000113086","abundance":9.29,"rank":4255,"name":"Smim11","annotation":"Small integral membrane protein 11A; Belongs to the SMIM11 family."},{"id":"ENSMUSP00000031556","abundance":9.28,"rank":4256,"name":"Tmem106b","annotation":"Transmembrane protein 106B; Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching (By similarity)."},{"id":"ENSMUSP00000045154","abundance":9.28,"rank":4257,"name":"Tmx4","annotation":"Thioredoxin-related transmembrane protein 4."},{"id":"ENSMUSP00000122360","abundance":9.28,"rank":4258,"name":"Rabepk","annotation":"Rab9 effector protein with kelch motifs; Rab9 effector required for endosome to trans-Golgi network (TGN) transport."},{"id":"ENSMUSP00000098728","abundance":9.28,"rank":4259,"name":"Gm5662","annotation":"Predicted gene, EG435337; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000002064","abundance":9.27,"rank":4260,"name":"Blvra","annotation":"Biliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily."},{"id":"ENSMUSP00000032065","abundance":9.27,"rank":4261,"name":"Pcyox1","annotation":"Prenylcysteine oxidase; Involved in the degradation of prenylated proteins. Cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine (By similarity); Belongs to the prenylcysteine oxidase family."},{"id":"ENSMUSP00000064131","abundance":9.26,"rank":4262,"name":"Gpc3","annotation":"Glypican-3 alpha subunit; Cell surface proteoglycan that bears heparan sulfate (By similarity). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (By similarity [...] "},{"id":"ENSMUSP00000038813","abundance":9.26,"rank":4263,"name":"Ube2r2","annotation":"Ubiquitin-conjugating enzyme E2 R2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin; Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000111330","abundance":9.26,"rank":4264,"name":"Otud5","annotation":"OTU domain-containing protein 5; Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro) (By similarity)."},{"id":"ENSMUSP00000046788","abundance":9.26,"rank":4265,"name":"Hook3","annotation":"Protein Hook homolog 3; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex (By similarity). Serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking. Acts as an adapter protein linking the dynein motor complex to [...] "},{"id":"ENSMUSP00000023781","abundance":9.25,"rank":4266,"name":"Krt88","annotation":"Keratin 88; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000112313","abundance":9.23,"rank":4267,"name":"Gm4907","annotation":"Predicted gene, EG236749."},{"id":"ENSMUSP00000071955","abundance":9.23,"rank":4268,"name":"Rrs1","annotation":"Ribosome biogenesis regulatory protein homolog; Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus."},{"id":"ENSMUSP00000097908","abundance":9.23,"rank":4269,"name":"Nsmf","annotation":"NMDA receptor synaptonuclear signaling and neuronal migration factor; Couples NMDA-sensitive glutamate receptor signaling to the nucleus and triggers long-lasting changes in the cytoarchitecture of dendrites and spine synapse processes. Part of the cAMP response element-binding protein (CREB) shut-off signaling pathway. Stimulates outgrowth of olfactory axons and migration of gonadotropin-releasing hormone (GnRH) and luteinizing-hormone-releasing hormone (LHRH) neuronal cells; Belongs to the NSMF family."},{"id":"ENSMUSP00000027929","abundance":9.23,"rank":4270,"name":"Mark1","annotation":"Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by p [...] "},{"id":"ENSMUSP00000145876","abundance":9.22,"rank":4271,"name":"Zg16","annotation":"Zymogen granule membrane protein 16; May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN (By similarity); Belongs to the jacalin lectin family."},{"id":"ENSMUSP00000047393","abundance":9.22,"rank":4272,"name":"Bpgm","annotation":"Bisphosphoglycerate mutase; Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily."},{"id":"ENSMUSP00000031741","abundance":9.22,"rank":4273,"name":"Cyp3a13","annotation":"Cytochrome P450 3A13; Can activate aflatoxin B1 to a genotoxic product."},{"id":"ENSMUSP00000122941","abundance":9.21,"rank":4274,"name":"Malsu1","annotation":"Mitochondrial assembly of ribosomal large subunit protein 1; Required for normal mitochondrial ribosome function and mitochondrial translation. May play a role in ribosome biogenesis by preventing premature association of the 28S and 39S ribosomal subunits. Interacts with mitochondrial ribosomal protein L14 (MRPL14), probably blocking formation of intersubunit bridge B8, preventing association of the 28S and 39S ribosomal subunits. Addition to isolated mitochondrial ribosomal subunits partially inhibits translation, probably by interfering with the association of the 28S and 39S riboso [...] "},{"id":"ENSMUSP00000097238","abundance":9.2,"rank":4275,"name":"Arl6","annotation":"ADP-ribosylation factor-like protein 6; Involved in membrane protein trafficking at the base of the ciliary organelle (By similarity). Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (By similarity). May regulate cilia assembl [...] "},{"id":"ENSMUSP00000150564","abundance":9.2,"rank":4276,"name":"Dcun1d5","annotation":"DCN1-like protein 5."},{"id":"ENSMUSP00000112089","abundance":9.19,"rank":4277,"name":"Rcor1","annotation":"REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase a [...] "},{"id":"ENSMUSP00000028551","abundance":9.19,"rank":4278,"name":"Emc4","annotation":"ER membrane protein complex subunit 4; May mediate anti-apoptotic activity."},{"id":"ENSMUSP00000091033","abundance":9.18,"rank":4279,"name":"4933402J07Rik","annotation":"RIKEN cDNA 4933402J07 gene."},{"id":"ENSMUSP00000022927","abundance":9.18,"rank":4280,"name":"Rad21","annotation":"Double-strand-break repair protein rad21 homolog; [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression [...] "},{"id":"ENSMUSP00000096266","abundance":9.17,"rank":4281,"name":"Ceacam1","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 1; [Isoform 1]: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis. Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T-cells, natural killer (NK) and neutrophils. Up [...] "},{"id":"ENSMUSP00000029387","abundance":9.17,"rank":4282,"name":"Eif2a","annotation":"Eukaryotic translation initiation factor 2A, N-terminally processed; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner."},{"id":"ENSMUSP00000025547","abundance":9.17,"rank":4283,"name":"Timm21","annotation":"Mitochondrial import inner membrane translocase subunit Tim21; Participates in the translocation of transit peptide- containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. Be [...] "},{"id":"ENSMUSP00000141856","abundance":9.17,"rank":4284,"name":"Apeh","annotation":"Acylamino-acid-releasing enzyme; This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser (By similarity)."},{"id":"ENSMUSP00000077891","abundance":9.17,"rank":4285,"name":"Tom1","annotation":"Target of Myb protein 1; May be involved in intracellular trafficking. Probable association with membranes."},{"id":"ENSMUSP00000152093","abundance":9.17,"rank":4286,"name":"Gm2001","annotation":"Ubiquitin-like protein 5."},{"id":"ENSMUSP00000152141","abundance":9.17,"rank":4287,"name":"Gm16381","annotation":"Predicted gene 16381."},{"id":"ENSMUSP00000036213","abundance":9.17,"rank":4288,"name":"Coq10a","annotation":"Coenzyme Q10A."},{"id":"ENSMUSP00000109585","abundance":9.17,"rank":4289,"name":"Wdr5","annotation":"WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). May regulate osteoblasts differentiation .In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] "},{"id":"ENSMUSP00000158936","abundance":9.16,"rank":4290,"name":"Nat8f1","annotation":"Probable N-acetyltransferase CML1; May play a role in regulation of gastrulation. Belongs to the camello family."},{"id":"ENSMUSP00000031670","abundance":9.16,"rank":4291,"name":"Gng11","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity)."},{"id":"ENSMUSP00000104136","abundance":9.16,"rank":4292,"name":"Slc1a5","annotation":"Neutral amino acid transporter B(0); Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids."},{"id":"ENSMUSP00000023965","abundance":9.15,"rank":4293,"name":"Cfhr1","annotation":"Complement factor H-related protein."},{"id":"ENSMUSP00000092283","abundance":9.14,"rank":4294,"name":"Rmdn3","annotation":"Regulator of microtubule dynamics protein 3; Involved in cellular calcium homeostasis regulation (By similarity). May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (By similarity). Belongs to the RMDN family."},{"id":"ENSMUSP00000109698","abundance":9.14,"rank":4295,"name":"Crygc","annotation":"Gamma-crystallin C; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000113413","abundance":9.14,"rank":4296,"name":"Apoa5","annotation":"Apolipoprotein A-V; Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages (By similarity). Binds heparin (By similarity)."},{"id":"ENSMUSP00000099987","abundance":9.14,"rank":4297,"name":"Aebp1","annotation":"Adipocyte enhancer-binding protein 1; [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix; Belongs to the peptidase M14 family."},{"id":"ENSMUSP00000021807","abundance":9.14,"rank":4298,"name":"Dek","annotation":"Protein DEK; Involved in chromatin organization."},{"id":"ENSMUSP00000027090","abundance":9.13,"rank":4299,"name":"Crygb","annotation":"Gamma-crystallin B; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000034621","abundance":9.13,"rank":4300,"name":"Nlrx1","annotation":"NLR family member X1; Participates in antiviral signaling; Belongs to the NLRP family."},{"id":"ENSMUSP00000044769","abundance":9.12,"rank":4301,"name":"Atg5","annotation":"Autophagy protein 5; Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is ess [...] "},{"id":"ENSMUSP00000121729","abundance":9.12,"rank":4302,"name":"Ces1h","annotation":"Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000071150","abundance":9.11,"rank":4303,"name":"Rffl","annotation":"E3 ubiquitin-protein ligase rififylin; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signal [...] "},{"id":"ENSMUSP00000124719","abundance":9.11,"rank":4304,"name":"Commd1","annotation":"COMM domain-containing protein 1; Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF- kappa-B activity. Involved in the regulation of membrane expression and ubiquiti [...] "},{"id":"ENSMUSP00000111339","abundance":9.11,"rank":4305,"name":"Gripap1","annotation":"GRIP1-associated protein 1; Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity- induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity)."},{"id":"ENSMUSP00000104208","abundance":9.1,"rank":4306,"name":"Arrb2","annotation":"Beta-arrestin-2; Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta- arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin- associated sorting proteins) and re [...] "},{"id":"ENSMUSP00000026236","abundance":9.1,"rank":4307,"name":"Tlx1","annotation":"T-cell leukemia homeobox protein 1; Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'."},{"id":"ENSMUSP00000093603","abundance":9.1,"rank":4308,"name":"Dusp22","annotation":"Dual specificity protein phosphatase 22; Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK)."},{"id":"ENSMUSP00000146674","abundance":9.1,"rank":4309,"name":"Trappc5","annotation":"Trafficking protein particle complex subunit 5; May play a role in vesicular transport from endoplasmic reticulum to Golgi; Belongs to the TRAPP small subunits family. BET3 subfamily."},{"id":"ENSMUSP00000068772","abundance":9.09,"rank":4310,"name":"Cebpzos","annotation":"Protein CEBPZOS."},{"id":"ENSMUSP00000073691","abundance":9.08,"rank":4311,"name":"Elmo2","annotation":"Engulfment and cell motility protein 2; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity)."},{"id":"ENSMUSP00000111221","abundance":9.07,"rank":4312,"name":"Dync1i1","annotation":"Cytoplasmic dynein 1 intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kine [...] "},{"id":"ENSMUSP00000038103","abundance":9.07,"rank":4313,"name":"Mcpt4","annotation":"Mast cell protease 4; Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala- 5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing."},{"id":"ENSMUSP00000046540","abundance":9.06,"rank":4314,"name":"Nup54","annotation":"Nuclear pore complex protein Nup54; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane."},{"id":"ENSMUSP00000062811","abundance":9.06,"rank":4315,"name":"Hscb","annotation":"Iron-sulfur cluster co-chaperone protein HscB, mitochondrial; Acts as a co-chaperone in iron-sulfur cluster assembly in both mitochondria and the cytoplasm. Required for incorporation of iron-sulfur clusters into SDHB, the iron-sulfur protein subunit of succinate dehydrogenase that is involved in complex II of the mitochondrial electron transport chain. Recruited to SDHB by interaction with SDHAF1 which first binds SDHB and then recruits the iron-sulfur transfer complex formed by HSC20, HSPA9 and ISCU through direct binding to HSC20. Also mediates complex formation between components o [...] "},{"id":"ENSMUSP00000034326","abundance":9.06,"rank":4316,"name":"Atp13a1","annotation":"Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity)."},{"id":"ENSMUSP00000065798","abundance":9.06,"rank":4317,"name":"Smad5","annotation":"Mothers against decapentaplegic homolog 5; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor- regulated SMAD (R-SMAD) (By similarity). Required for angiogenesis. Belongs to the dwarfin/SMAD family."},{"id":"ENSMUSP00000072264","abundance":9.06,"rank":4318,"name":"Cyp2b10","annotation":"Cytochrome P450 2B10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000033915","abundance":9.05,"rank":4319,"name":"Gpm6a","annotation":"Neuronal membrane glycoprotein M6-a; Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. Conflictingly, reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a func [...] "},{"id":"ENSMUSP00000032410","abundance":9.04,"rank":4320,"name":"Tada3","annotation":"Transcriptional adapter 3; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53- dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity); Belongs to the NGG1 family."},{"id":"ENSMUSP00000027266","abundance":9.03,"rank":4321,"name":"Ormdl1","annotation":"ORM1-like protein 1; Negative regulator of sphingolipid synthesis; Belongs to the ORM family."},{"id":"ENSMUSP00000021793","abundance":9.02,"rank":4322,"name":"Elovl2","annotation":"Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the productio [...] "},{"id":"ENSMUSP00000000199","abundance":9.02,"rank":4323,"name":"Ncs1","annotation":"Neuronal calcium sensor 1; Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage- gated calcium channel (By similarity); Belongs to the recoverin family."},{"id":"ENSMUSP00000080601","abundance":9.02,"rank":4324,"name":"Dtx3l","annotation":"E3 ubiquitin-protein ligase DTX3L; E3 ubiquitin-protein ligase which, in association with ADP- ribosyltransferase PARP9, plays a role in DNA damage repair and in interferon-mediated antiviral responses. Monoubiquitinates several histones, including histone H2A, H2B, H3 and H4. In response to DNA damage, mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1). The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). PARP1-depe [...] "},{"id":"ENSMUSP00000063166","abundance":9.02,"rank":4325,"name":"Prkaa1","annotation":"5'-AMP-activated protein kinase catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] "},{"id":"ENSMUSP00000107873","abundance":9.01,"rank":4326,"name":"Vwf","annotation":"Von Willebrand antigen 2; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma."},{"id":"ENSMUSP00000070314","abundance":9.01,"rank":4327,"name":"Cmbl","annotation":"Carboxymethylenebutenolidase homolog; Cysteine hydrolase; Belongs to the dienelactone hydrolase family."},{"id":"ENSMUSP00000079232","abundance":8.99,"rank":4328,"name":"Akr1c20","annotation":"Aldo-keto reductase family 1, member C20."},{"id":"ENSMUSP00000103243","abundance":8.98,"rank":4329,"name":"Kirrel","annotation":"Kin of IRRE-like protein 1; Plays a significant role in the normal development and function of the glomerular permeability. Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1; Belongs to the immunoglobulin superfamily."},{"id":"ENSMUSP00000077471","abundance":8.98,"rank":4330,"name":"Vrk2","annotation":"Serine/threonine-protein kinase VRK2; Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen- activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates histone H3. Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and ac [...] "},{"id":"ENSMUSP00000104864","abundance":8.97,"rank":4331,"name":"Snx18","annotation":"Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. P [...] "},{"id":"ENSMUSP00000014892","abundance":8.97,"rank":4332,"name":"Tex261","annotation":"Protein TEX261."},{"id":"ENSMUSP00000063005","abundance":8.97,"rank":4333,"name":"Ces2b","annotation":"Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000113304","abundance":8.96,"rank":4334,"name":"Pex1","annotation":"Peroxisome biogenesis factor 1; Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity)."},{"id":"ENSMUSP00000021339","abundance":8.95,"rank":4335,"name":"Dtd2","annotation":"D-aminoacyl-tRNA deacylase 2; Deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids. Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr). By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protei [...] "},{"id":"ENSMUSP00000134799","abundance":8.95,"rank":4336,"name":"Golph3l","annotation":"Golgi phosphoprotein 3-like; Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane."},{"id":"ENSMUSP00000028139","abundance":8.94,"rank":4337,"name":"Med27","annotation":"Mediator of RNA polymerase II transcription subunit 27; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000036299","abundance":8.94,"rank":4338,"name":"Slc32a1","annotation":"Vesicular inhibitory amino acid transporter; Involved in the uptake of GABA and glycine into the synaptic vesicles."},{"id":"ENSMUSP00000025515","abundance":8.93,"rank":4339,"name":"Tmx3","annotation":"Protein disulfide-isomerase TMX3; Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase (By similarity)."},{"id":"ENSMUSP00000125407","abundance":8.93,"rank":4340,"name":"Nrxn1","annotation":"Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect  [...] "},{"id":"ENSMUSP00000000500","abundance":8.93,"rank":4341,"name":"Pdgfb","annotation":"Platelet-derived growth factor subunit B; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers wit [...] "},{"id":"ENSMUSP00000092252","abundance":8.92,"rank":4342,"name":"Pla2g4d","annotation":"Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Compared to its human ortholog, may have no preference for the fatty acid found at the sn-2 position."},{"id":"ENSMUSP00000115756","abundance":8.89,"rank":4343,"name":"St3gal6","annotation":"Type 2 lactosamine alpha-2,3-sialyltransferase; Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1 (By similarity). Belongs to the glycosyltransferase 29 family."},{"id":"ENSMUSP00000032336","abundance":8.89,"rank":4344,"name":"Plbd1","annotation":"Phospholipase B-like 1 chain A; Exhibits weak phospholipase activity, acting on various phospholipids, including phosphatidylcholine, phosphatidylinositol, phosphatidylethanolamine and lysophospholipids. However, in view of the small size of the putative binding pocket, it has been proposed that it may act rather as an amidase or a peptidase (By similarity)."},{"id":"ENSMUSP00000105793","abundance":8.88,"rank":4345,"name":"Tmem230","annotation":"Transmembrane protein 230; Involved in trafficking and recycling of synaptic vesicles."},{"id":"ENSMUSP00000019422","abundance":8.86,"rank":4346,"name":"Dpep1","annotation":"Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity."},{"id":"ENSMUSP00000139365","abundance":8.86,"rank":4347,"name":"Tcf12","annotation":"Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3')."},{"id":"ENSMUSP00000122252","abundance":8.85,"rank":4348,"name":"Flad1","annotation":"Molybdenum cofactor biosynthesis protein-like region; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme; In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily."},{"id":"ENSMUSP00000117725","abundance":8.84,"rank":4349,"name":"Zpr1","annotation":"Zinc finger protein ZPR1; Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death; Belongs to the ZPR1 family."},{"id":"ENSMUSP00000042988","abundance":8.83,"rank":4350,"name":"Thrsp","annotation":"Thyroid hormone-inducible hepatic protein; Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity). Belongs to the SPOT14 family."},{"id":"ENSMUSP00000155552","abundance":8.83,"rank":4351,"name":"Gtse1","annotation":"G2 and S phase-expressed protein 1; May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression."},{"id":"ENSMUSP00000112534","abundance":8.83,"rank":4352,"name":"Fam20b","annotation":"Glycosaminoglycan xylosylkinase; Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O- phosphorylation may influence the catalyti [...] "},{"id":"ENSMUSP00000017144","abundance":8.82,"rank":4353,"name":"Svs6","annotation":"Seminal vesicle secretory protein 6."},{"id":"ENSMUSP00000110813","abundance":8.82,"rank":4354,"name":"Tmem209","annotation":"Transmembrane protein 209."},{"id":"ENSMUSP00000034164","abundance":8.82,"rank":4355,"name":"Ist1","annotation":"IST1 homolog; ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together wi [...] "},{"id":"ENSMUSP00000015858","abundance":8.82,"rank":4356,"name":"Cers2","annotation":"Ceramide synthase 2; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward very- long (C22:0-C24:0) chain as acyl donor."},{"id":"ENSMUSP00000020317","abundance":8.81,"rank":4357,"name":"Pno1","annotation":"RNA-binding protein PNO1; Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. Belongs to the PNO1 family."},{"id":"ENSMUSP00000014248","abundance":8.8,"rank":4358,"name":"Sval2","annotation":"Seminal vesicle antigen-like 2."},{"id":"ENSMUSP00000035094","abundance":8.8,"rank":4359,"name":"Exog","annotation":"Nuclease EXOG, mitochondrial; Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity."},{"id":"ENSMUSP00000025999","abundance":8.79,"rank":4360,"name":"Add3","annotation":"Gamma-adducin; Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin; Belongs to the aldolase class II family. Adducin subfamily."},{"id":"ENSMUSP00000093614","abundance":8.79,"rank":4361,"name":"Prl7a1","annotation":"Prolactin-7A1; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000074386","abundance":8.78,"rank":4362,"name":"Ear2","annotation":"Eosinophil cationic protein 2; Cytotoxin and helminthotoxin with ribonuclease activity. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities."},{"id":"ENSMUSP00000075356","abundance":8.78,"rank":4363,"name":"Mup4","annotation":"Major urinary protein 4; Binds pheromones, likely to displace pheromones complexed to urinary MUPs and transport them to the vomeronasal organ (VNO) where they associate with their neuronal receptor(s). MUP4 is highly specific for the male mouse pheromone 2-sec-butyl-4,5-dihydrothiazole (SBT)."},{"id":"ENSMUSP00000090672","abundance":8.78,"rank":4364,"name":"Myh7b","annotation":"Myosin-7B; Involved in muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000100991","abundance":8.77,"rank":4365,"name":"Reep6","annotation":"Receptor expression-enhancing protein 6; Required for correct function and survival of retinal photoreceptors. Required for retinal development. In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis. May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane."},{"id":"ENSMUSP00000078042","abundance":8.76,"rank":4366,"name":"Bloc1s2","annotation":"Biogenesis of lysosome-related organelles complex 1 subunit 2; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (By similarity). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in l [...] "},{"id":"ENSMUSP00000030032","abundance":8.76,"rank":4367,"name":"Tmeff1","annotation":"Tomoregulin-1; May inhibit NODAL and BMP signaling during neural patterning. Belongs to the tomoregulin family."},{"id":"ENSMUSP00000092499","abundance":8.76,"rank":4368,"name":"Ccnyl1","annotation":"Cyclin Y-like 1."},{"id":"ENSMUSP00000031227","abundance":8.75,"rank":4369,"name":"Zfp326","annotation":"DBIRD complex subunit ZNF326; Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions (By similarity). May also play a role in neuronal differentiation. Able to bind DNA and activate expression in vitro."},{"id":"ENSMUSP00000079752","abundance":8.75,"rank":4370,"name":"Lrp2","annotation":"Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins. Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin. Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated r [...] "},{"id":"ENSMUSP00000026559","abundance":8.75,"rank":4371,"name":"Sirt3","annotation":"NAD-dependent protein deacetylase sirtuin-3; NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5PO. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription. Acts as a regulator of ceram [...] "},{"id":"ENSMUSP00000021179","abundance":8.74,"rank":4372,"name":"Vmo1","annotation":"Vitelline membrane outer layer protein 1 homolog."},{"id":"ENSMUSP00000148115","abundance":8.74,"rank":4373,"name":"Nup98","annotation":"Nuclear pore complex protein Nup98-Nup96; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body)."},{"id":"ENSMUSP00000111173","abundance":8.74,"rank":4374,"name":"Phf14","annotation":"PHD finger protein 14."},{"id":"ENSMUSP00000070572","abundance":8.71,"rank":4375,"name":"Mia2","annotation":"Melanoma inhibitory activity protein 2; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (By similarity). Thereby, may play a role in cholesterol and triglyceride homeostasis. Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PR [...] "},{"id":"ENSMUSP00000044326","abundance":8.71,"rank":4376,"name":"Slco1b2","annotation":"Solute carrier organic anion transporter family member 1B2; Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates such as estrone-3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate and prostaglandin E2; Belongs to the organo anion transporter (TC 2.A.60) family."},{"id":"ENSMUSP00000056774","abundance":8.71,"rank":4377,"name":"Pik3r1","annotation":"Phosphatidylinositol 3-kinase regulatory subunit alpha; Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nucle [...] "},{"id":"ENSMUSP00000001963","abundance":8.71,"rank":4378,"name":"Ace","annotation":"Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. This GPIase activity seems to be crucial for the egg- binding ability of the sperm; Belongs to the peptidase M2 family."},{"id":"ENSMUSP00000157137","abundance":8.71,"rank":4379,"name":"Mlst8","annotation":"Target of rapamycin complex subunit LST8; Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-r [...] "},{"id":"ENSMUSP00000110118","abundance":8.7,"rank":4380,"name":"Plet1","annotation":"Placenta-expressed transcript 1 protein; Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle."},{"id":"ENSMUSP00000107627","abundance":8.69,"rank":4381,"name":"Atp5g3","annotation":"ATP synthase F(0) complex subunit C3, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanis [...] "},{"id":"ENSMUSP00000099981","abundance":8.69,"rank":4382,"name":"Col15a1","annotation":"Collagen alpha-1(XV) chain; Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle; Belongs to the multiplexin collagen family."},{"id":"ENSMUSP00000132832","abundance":8.68,"rank":4383,"name":"Cyp2c69","annotation":"Cytochrome P450, family 2, subfamily c, polypeptide 69; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000047680","abundance":8.67,"rank":4384,"name":"Prl3b1","annotation":"Prolactin-3B1; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000025833","abundance":8.67,"rank":4385,"name":"Papss2","annotation":"Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have  [...] "},{"id":"ENSMUSP00000115320","abundance":8.66,"rank":4386,"name":"Txnl4a","annotation":"Thioredoxin-like protein 4A; Plays role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes that are involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)."},{"id":"ENSMUSP00000005817","abundance":8.66,"rank":4387,"name":"Tomm40l","annotation":"Mitochondrial import receptor subunit TOM40B; Potential channel-forming protein implicated in import of protein precursors into mitochondria."},{"id":"ENSMUSP00000034879","abundance":8.66,"rank":4388,"name":"Hmg20a","annotation":"High mobility group protein 20A; Plays a role in neuronal differentiation as chromatin- associated protein. Acts as inhibitor of HMG20B. Overcomes the repressive effects of the neuronal silencer REST and induces the activation of neuronal-specific genes. Involved in the recruitment of the histone methyltransferase KMT2A/MLL1 and consequent increased methylation of histone H3 lysine 4."},{"id":"ENSMUSP00000105234","abundance":8.65,"rank":4389,"name":"Atf4","annotation":"Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to asymmetric CRE's as a heterodimer and to palindromic CRE's as a homodimer. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription [...] "},{"id":"ENSMUSP00000006915","abundance":8.65,"rank":4390,"name":"Mettl1","annotation":"tRNA (guanine-N(7)-)-methyltransferase; Methyltransferase that mediates the formation of N(7)- methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)- methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let- 7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secon [...] "},{"id":"ENSMUSP00000022696","abundance":8.65,"rank":4391,"name":"Xpo7","annotation":"Exportin-7; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate ano [...] "},{"id":"ENSMUSP00000076491","abundance":8.65,"rank":4392,"name":"Rxra","annotation":"Retinoic acid receptor RXR-alpha; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (RARs) and binds to target response elements in response to their ligands, all-trans or 9- cis retinoic acid, to regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for retinoid X receptors (RXRs) is 9-cis retinoic acid. In the absence of ligand, t [...] "},{"id":"ENSMUSP00000131649","abundance":8.65,"rank":4393,"name":"Gcat-2","annotation":"2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial."},{"id":"ENSMUSP00000032840","abundance":8.65,"rank":4394,"name":"Mrps11","annotation":"28S ribosomal protein S11, mitochondrial; Belongs to the universal ribosomal protein uS11 family."},{"id":"ENSMUSP00000027291","abundance":8.64,"rank":4395,"name":"Zap70","annotation":"Tyrosine-protein kinase ZAP-70; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates motility, adhesion and cytokine expression of mature T-cells, as well as thymocyte development. Contributes also to the development and activation of primary B- lymphocytes. When antigen presenting cells (APC) activate T-cell receptor (TCR), a serie of phosphorylations lead to the recruitment of ZAP70 to the doubly phosphorylated TCR component CD3Z through ITAM motif at the plasma membrane. This recruitment serves to localization to the stimulated TCR an [...] "},{"id":"ENSMUSP00000034371","abundance":8.63,"rank":4396,"name":"Dpep3","annotation":"Dipeptidase 3; Probable metalloprotease which hydrolyzes cystinyl-bis- glycine. May be involved in meiosis."},{"id":"ENSMUSP00000025393","abundance":8.62,"rank":4397,"name":"Smad4","annotation":"Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] "},{"id":"ENSMUSP00000122274","abundance":8.61,"rank":4398,"name":"Abhd5","annotation":"1-acylglycerol-3-phosphate O-acyltransferase ABHD5; Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl- lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1- stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycero [...] "},{"id":"ENSMUSP00000049605","abundance":8.61,"rank":4399,"name":"Pycrl","annotation":"Pyrroline-5-carboxylate reductase 3; Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline."},{"id":"ENSMUSP00000002529","abundance":8.6,"rank":4400,"name":"Prpf6","annotation":"Pre-mRNA-processing factor 6; Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation."},{"id":"ENSMUSP00000122403","abundance":8.6,"rank":4401,"name":"Nfyb","annotation":"Nuclear transcription factor Y subunit beta; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors; Belongs to the NFYB/HAP3 subunit family."},{"id":"ENSMUSP00000000767","abundance":8.6,"rank":4402,"name":"Rpa1","annotation":"Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruit [...] "},{"id":"ENSMUSP00000063309","abundance":8.59,"rank":4403,"name":"Akr1cl","annotation":"Aldo-keto reductase family 1, member C-like."},{"id":"ENSMUSP00000138729","abundance":8.59,"rank":4404,"name":"Sept14","annotation":"Septin-14; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential)."},{"id":"ENSMUSP00000117294","abundance":8.57,"rank":4405,"name":"Sft2d1","annotation":"SFT2 domain containing 1."},{"id":"ENSMUSP00000090857","abundance":8.57,"rank":4406,"name":"Gm12166","annotation":"Vesicle transport protein SFT2A; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family."},{"id":"ENSMUSP00000123564","abundance":8.57,"rank":4407,"name":"Sort1","annotation":"Sortilin; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differ [...] "},{"id":"ENSMUSP00000090281","abundance":8.55,"rank":4408,"name":"Aup1","annotation":"Ancient ubiquitous protein 1; May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome; Belongs to the AUP1 family."},{"id":"ENSMUSP00000023856","abundance":8.55,"rank":4409,"name":"Msrb2","annotation":"Methionine-R-sulfoxide reductase B2, mitochondrial; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maint [...] "},{"id":"ENSMUSP00000100041","abundance":8.54,"rank":4410,"name":"Gata3","annotation":"Trans-acting T-cell-specific transcription factor GATA-3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses."},{"id":"ENSMUSP00000123324","abundance":8.54,"rank":4411,"name":"Mrps26","annotation":"28S ribosomal protein S26, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS26 family."},{"id":"ENSMUSP00000122964","abundance":8.54,"rank":4412,"name":"Arfip1","annotation":"ADP-ribosylation factor-interacting protein 1."},{"id":"ENSMUSP00000108694","abundance":8.54,"rank":4413,"name":"Tmsb15b1","annotation":"Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family."},{"id":"ENSMUSP00000020461","abundance":8.54,"rank":4414,"name":"Nfic","annotation":"Nuclear factor 1 C-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication; Belongs to the CTF/NF-I family."},{"id":"ENSMUSP00000062794","abundance":8.54,"rank":4415,"name":"Sptssb","annotation":"Serine palmitoyltransferase small subunit B; Stimulates the activity of serine palmitoyltransferase (SPT). The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference, complexes with this subunit showing a clear preference for longer acyl-CoAs. The SPTLC1-SPTLC2- SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference."},{"id":"ENSMUSP00000028915","abundance":8.54,"rank":4416,"name":"Rbbp9","annotation":"Putative hydrolase RBBP9; Serine hydrolase whose substrates have not been identified yet. May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation. May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1; Belongs to the RBBP9 family."},{"id":"ENSMUSP00000093030","abundance":8.53,"rank":4417,"name":"Tmem263","annotation":"Transmembrane protein 263."},{"id":"ENSMUSP00000080630","abundance":8.53,"rank":4418,"name":"Hopx","annotation":"Homeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF- dependent cardiac-specific genes and cardiac development. Prevents SRF- dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein ref [...] "},{"id":"ENSMUSP00000144257","abundance":8.53,"rank":4419,"name":"Slc4a1ap","annotation":"Solute carrier family 4 (anion exchanger), member 1, adaptor protein."},{"id":"ENSMUSP00000039335","abundance":8.53,"rank":4420,"name":"Timm8b","annotation":"Mitochondrial import inner membrane translocase subunit Tim8 B; Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity); Belongs to the small Tim family."},{"id":"ENSMUSP00000075716","abundance":8.53,"rank":4421,"name":"Csn1s2a","annotation":"Alpha-S2-casein-like A; Important role in the capacity of milk to transport calcium phosphate."},{"id":"ENSMUSP00000148478","abundance":8.53,"rank":4422,"name":"Cdh16","annotation":"Cadherin-16; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."},{"id":"ENSMUSP00000088029","abundance":8.52,"rank":4423,"name":"Atp5g1","annotation":"ATP synthase F(0) complex subunit C1, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanis [...] "},{"id":"ENSMUSP00000143859","abundance":8.52,"rank":4424,"name":"Ube3a","annotation":"Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo [...] "},{"id":"ENSMUSP00000023882","abundance":8.52,"rank":4425,"name":"Sympk","annotation":"Symplekin; Scaffold protein that functions as a component of a multimolecular complex involved in histone mRNA 3'-end processing. Specific component of the tight junction (TJ) plaque, but might not be an exclusively junctional component. May have a house-keeping rule. Is involved in pre-mRNA polyadenylation. Enhances SSU72 phosphatase activity (By similarity); Belongs to the Symplekin family."},{"id":"ENSMUSP00000001675","abundance":8.52,"rank":4426,"name":"Stk38l","annotation":"Serine/threonine-protein kinase 38-like; Involved in the regulation of structural processes in differentiating and mature neuronal cells."},{"id":"ENSMUSP00000105527","abundance":8.52,"rank":4427,"name":"Papola","annotation":"Poly(A) polymerase alpha; Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C- terminus."},{"id":"ENSMUSP00000117229","abundance":8.51,"rank":4428,"name":"Gm20521","annotation":"Predicted gene 20521."},{"id":"ENSMUSP00000099859","abundance":8.51,"rank":4429,"name":"Ublcp1","annotation":"Ubiquitin-like domain-containing CTD phosphatase 1; Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity)."},{"id":"ENSMUSP00000075935","abundance":8.5,"rank":4430,"name":"1810009J06Rik","annotation":"RIKEN cDNA 1810009J06 gene; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000130465","abundance":8.5,"rank":4431,"name":"Gm2663","annotation":"Predicted gene 2663; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000023343","abundance":8.5,"rank":4432,"name":"Atg3","annotation":"Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8- phosphatidylethanolamine conju [...] "},{"id":"ENSMUSP00000128000","abundance":8.5,"rank":4433,"name":"Sorbs2","annotation":"Sorbin and SH3 domain-containing protein 2; Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity)."},{"id":"ENSMUSP00000139566","abundance":8.5,"rank":4434,"name":"Rgs6","annotation":"Regulator of G-protein signaling 6; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity."},{"id":"ENSMUSP00000022709","abundance":8.49,"rank":4435,"name":"Spry2","annotation":"Protein sprouty homolog 2; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Belongs to the sprouty family."},{"id":"ENSMUSP00000028118","abundance":8.49,"rank":4436,"name":"Prkcq","annotation":"Protein kinase C theta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transact [...] "},{"id":"ENSMUSP00000044342","abundance":8.49,"rank":4437,"name":"Lgalsl","annotation":"Galectin-related protein; Does not bind lactose, and may not bind carbohydrates."},{"id":"ENSMUSP00000025193","abundance":8.49,"rank":4438,"name":"Brd2","annotation":"Bromodomain-containing protein 2; Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly (By similarity). May play a role in spermatogenesis or folliculogenesis."},{"id":"ENSMUSP00000105773","abundance":8.48,"rank":4439,"name":"Mef2b","annotation":"Myocyte-specific enhancer factor 2B; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription."},{"id":"ENSMUSP00000101061","abundance":8.47,"rank":4440,"name":"Specc1l","annotation":"Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity); Belongs to the cytospin-A family."},{"id":"ENSMUSP00000006557","abundance":8.46,"rank":4441,"name":"Elovl1","annotation":"Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain leng [...] "},{"id":"ENSMUSP00000070229","abundance":8.46,"rank":4442,"name":"Gatad2a","annotation":"Transcriptional repressor p66 alpha; Transcriptional repressor (By similarity). Enhances MBD2- mediated repression. Efficient repression requires the presence of GATAD2B (By similarity)."},{"id":"ENSMUSP00000149938","abundance":8.44,"rank":4443,"name":"Gnb5","annotation":"Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] "},{"id":"ENSMUSP00000031843","abundance":8.44,"rank":4444,"name":"Npy","annotation":"C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family."},{"id":"ENSMUSP00000068587","abundance":8.44,"rank":4445,"name":"Strip1","annotation":"Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity); Belongs to the STRIP family."},{"id":"ENSMUSP00000146858","abundance":8.44,"rank":4446,"name":"Htatip2","annotation":"Oxidoreductase HTATIP2; Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import."},{"id":"ENSMUSP00000054958","abundance":8.43,"rank":4447,"name":"Cypt4","annotation":"Cysteine-rich perinuclear theca protein 4."},{"id":"ENSMUSP00000123979","abundance":8.42,"rank":4448,"name":"Chit1","annotation":"Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens (By similarity). Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily."},{"id":"ENSMUSP00000101461","abundance":8.42,"rank":4449,"name":"Rap1gap","annotation":"Rap1 GTPase-activating protein 1; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP- bound state."},{"id":"ENSMUSP00000102624","abundance":8.41,"rank":4450,"name":"Arap1","annotation":"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity)."},{"id":"ENSMUSP00000019611","abundance":8.41,"rank":4451,"name":"Arhgef25","annotation":"Rho guanine nucleotide exchange factor 25; May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation (By similarity). May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis."},{"id":"ENSMUSP00000077594","abundance":8.4,"rank":4452,"name":"Rtn1","annotation":"Reticulon-1; May be involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells."},{"id":"ENSMUSP00000102711","abundance":8.4,"rank":4453,"name":"Jun","annotation":"Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 (By similarity). Binds to the USP28 promoter (By similarity)."},{"id":"ENSMUSP00000080284","abundance":8.4,"rank":4454,"name":"Syt17","annotation":"Synaptotagmin-17; Plays a role in dendrite formation by melanocytes. Belongs to the synaptotagmin family."},{"id":"ENSMUSP00000038878","abundance":8.4,"rank":4455,"name":"Aldh8a1","annotation":"2-aminomuconic semialdehyde dehydrogenase; Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation."},{"id":"ENSMUSP00000088263","abundance":8.39,"rank":4456,"name":"Acp6","annotation":"Lysophosphatidic acid phosphatase type 6; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid. Belongs to the histidine acid phosphatase family."},{"id":"ENSMUSP00000018610","abundance":8.39,"rank":4457,"name":"Nos2","annotation":"Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS- S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (By similarity [...] "},{"id":"ENSMUSP00000111961","abundance":8.38,"rank":4458,"name":"Tnfrsf9","annotation":"Tumor necrosis factor receptor superfamily member 9; Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation."},{"id":"ENSMUSP00000024727","abundance":8.38,"rank":4459,"name":"Cdc5l","annotation":"Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR); Belongs to the CEF1 family."},{"id":"ENSMUSP00000006721","abundance":8.35,"rank":4460,"name":"Cryba2","annotation":"Beta-crystallin A2; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000094513","abundance":8.35,"rank":4461,"name":"Ttc9c","annotation":"Tetratricopeptide repeat protein 9C; Belongs to the TTC9 family."},{"id":"ENSMUSP00000080742","abundance":8.35,"rank":4462,"name":"Gzmd","annotation":"Granzyme D; This enzyme is probably necessary for target cell lysis in cell-mediated immune responses; Belongs to the peptidase S1 family. Granzyme subfamily."},{"id":"ENSMUSP00000054356","abundance":8.34,"rank":4463,"name":"Kcnj10","annotation":"ATP-sensitive inward rectifier potassium channel 10; May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellu [...] "},{"id":"ENSMUSP00000046789","abundance":8.34,"rank":4464,"name":"Foxf2","annotation":"Forkhead box protein F2; Probable transcription activator for a number of lung- specific genes. Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1 (By similarity)."},{"id":"ENSMUSP00000066897","abundance":8.34,"rank":4465,"name":"Sult2a8","annotation":"Sulfotransferase; Belongs to the sulfotransferase 1 family."},{"id":"ENSMUSP00000064719","abundance":8.33,"rank":4466,"name":"Efemp2","annotation":"EGF-containing fibulin-like extracellular matrix protein 2; Belongs to the fibulin family."},{"id":"ENSMUSP00000024575","abundance":8.33,"rank":4467,"name":"Rps6ka2","annotation":"Ribosomal protein S6 kinase alpha-2; Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells (By similarity)."},{"id":"ENSMUSP00000028205","abundance":8.32,"rank":4468,"name":"BC005624","annotation":"Telomere length and silencing protein 1 homolog; Involved in the regulation of telomeric heterochromatin assembly and control of telomere length."},{"id":"ENSMUSP00000033074","abundance":8.32,"rank":4469,"name":"Vkorc1","annotation":"Vitamin K epoxide reductase complex subunit 1; Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development."},{"id":"ENSMUSP00000095558","abundance":8.32,"rank":4470,"name":"Mier1","annotation":"Mesoderm induction early response protein 1; Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing."},{"id":"ENSMUSP00000009256","abundance":8.32,"rank":4471,"name":"Bcl2l13","annotation":"Bcl-2-like protein 13; May promote the activation of caspase-3 and apoptosis."},{"id":"ENSMUSP00000021249","abundance":8.32,"rank":4472,"name":"Scrn2","annotation":"Secernin-2; Belongs to the peptidase C69 family. Secernin subfamily."},{"id":"ENSMUSP00000064511","abundance":8.31,"rank":4473,"name":"Tmem255a","annotation":"Transmembrane protein 255A; Belongs to the TMEM255 family."},{"id":"ENSMUSP00000057532","abundance":8.31,"rank":4474,"name":"Hrk","annotation":"Activator of apoptosis harakiri; Promotes apoptosis."},{"id":"ENSMUSP00000015664","abundance":8.31,"rank":4475,"name":"Ctsk","annotation":"Cathepsin K; Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen ; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000132725","abundance":8.31,"rank":4476,"name":"Ciao2b","annotation":"Cytosolic iron-sulfur assembly component 2B; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD."},{"id":"ENSMUSP00000037107","abundance":8.3,"rank":4477,"name":"Mboat7","annotation":"Lysophospholipid acyltransferase 7; Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1- acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2- diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (By similarity). Required for cortical laminat [...] "},{"id":"ENSMUSP00000133992","abundance":8.3,"rank":4478,"name":"Scyl2","annotation":"SCY1-like protein 2; Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. May be a serine/threonine-protein kinase. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (By similarity)."},{"id":"ENSMUSP00000063762","abundance":8.29,"rank":4479,"name":"Vps37d","annotation":"Vacuolar protein sorting-associated protein 37D; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity); Belongs to the VPS37 family."},{"id":"ENSMUSP00000092836","abundance":8.29,"rank":4480,"name":"Ces1a","annotation":"Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000105386","abundance":8.28,"rank":4481,"name":"Nfix","annotation":"Nuclear factor 1 X-type; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Isoform NFIX1 acts as a transcriptional activator while isoform NFIX3 acts as a repressor; Belongs to the CTF/NF-I family."},{"id":"ENSMUSP00000081557","abundance":8.28,"rank":4482,"name":"Whrn","annotation":"Whirlin; Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport."},{"id":"ENSMUSP00000050295","abundance":8.28,"rank":4483,"name":"Cradd","annotation":"Death domain-containing protein CRADD; Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway."},{"id":"ENSMUSP00000034740","abundance":8.27,"rank":4484,"name":"Nedd4","annotation":"E3 ubiquitin-protein ligase NEDD4; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (By similarity). Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1. Predominantly involved in ubiquiti [...] "},{"id":"ENSMUSP00000106735","abundance":8.27,"rank":4485,"name":"Psen2","annotation":"Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins (By similarity). The holoprotein functions as a calcium-leak channel that allows the pa [...] "},{"id":"ENSMUSP00000129654","abundance":8.27,"rank":4486,"name":"Ppp4r3a","annotation":"Serine/threonine-protein phosphatase 4 regulatory subunit 3A; Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair (By similarity); Belongs to the SMEK family."},{"id":"ENSMUSP00000034955","abundance":8.27,"rank":4487,"name":"Spg21","annotation":"Maspardin; May play a role as a negative regulatory factor in CD4- dependent T-cell activation."},{"id":"ENSMUSP00000001520","abundance":8.27,"rank":4488,"name":"Afg3l1","annotation":"AFG3-like protein 1; Putative ATP-dependent protease. Required for the maturation of paraplegin (SPG7) after its cleavage by mitochondrial-processing peptidase (MPP), converting it into a proteolytically active mature form."},{"id":"ENSMUSP00000146680","abundance":8.26,"rank":4489,"name":"Pnpla6","annotation":"Neuropathy target esterase; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Belongs to the NTE family."},{"id":"ENSMUSP00000078123","abundance":8.26,"rank":4490,"name":"Mrpl18","annotation":"39S ribosomal protein L18, mitochondrial; Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity)."},{"id":"ENSMUSP00000025050","abundance":8.24,"rank":4491,"name":"Nudt3","annotation":"Diphosphoinositol polyphosphate phosphohydrolase 1; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate (By simila [...] "},{"id":"ENSMUSP00000028691","abundance":8.24,"rank":4492,"name":"Arfgap2","annotation":"ADP-ribosylation factor GTPase-activating protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). May regulate coatomer-mediated protein transport from the Golgi complex to the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)."},{"id":"ENSMUSP00000102981","abundance":8.24,"rank":4493,"name":"Stat5b","annotation":"Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation."},{"id":"ENSMUSP00000072336","abundance":8.24,"rank":4494,"name":"Adgrl3","annotation":"Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex."},{"id":"ENSMUSP00000070345","abundance":8.23,"rank":4495,"name":"Bckdk","annotation":"[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial; Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. Belongs to the PDK/BCKDK protein kinase family."},{"id":"ENSMUSP00000089009","abundance":8.23,"rank":4496,"name":"Cubn","annotation":"Cubilin; Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal t [...] "},{"id":"ENSMUSP00000127941","abundance":8.23,"rank":4497,"name":"Inpp5d","annotation":"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (By similarity). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), p [...] "},{"id":"ENSMUSP00000049315","abundance":8.23,"rank":4498,"name":"Ces2g","annotation":"Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000000687","abundance":8.22,"rank":4499,"name":"Haao","annotation":"3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate."},{"id":"ENSMUSP00000157124","abundance":8.21,"rank":4500,"name":"Rab36","annotation":"Ras-related protein Rab-36; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000050832","abundance":8.21,"rank":4501,"name":"Sned1","annotation":"Sushi, nidogen and EGF-like domain-containing protein 1."},{"id":"ENSMUSP00000044955","abundance":8.21,"rank":4502,"name":"Hacd3","annotation":"Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursor [...] "},{"id":"ENSMUSP00000147517","abundance":8.2,"rank":4503,"name":"Gm5678","annotation":"Predicted gene 5678; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000026987","abundance":8.2,"rank":4504,"name":"Nop16","annotation":"Nucleolar protein 16."},{"id":"ENSMUSP00000023365","abundance":8.2,"rank":4505,"name":"Bfar","annotation":"Bifunctional apoptosis regulator; Apoptosis regulator. Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (By similarity)."},{"id":"ENSMUSP00000041644","abundance":8.19,"rank":4506,"name":"Brk1","annotation":"Protein BRICK1; Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes."},{"id":"ENSMUSP00000096712","abundance":8.19,"rank":4507,"name":"Itga7","annotation":"Integrin alpha-7 heavy chain; Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Mice carrying a ITGA7 null allele are viable and fertile, but show progressive muscular dystrophy starting soon after birth, but with a distinct variabi [...] "},{"id":"ENSMUSP00000025505","abundance":8.19,"rank":4508,"name":"Dctn4","annotation":"Dynactin subunit 4; Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton."},{"id":"ENSMUSP00000001507","abundance":8.18,"rank":4509,"name":"Cyp51","annotation":"Lanosterol 14-alpha demethylase; A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25- dihydrolanosterol likely through sequential oxidative conversion of 14- alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P45 [...] "},{"id":"ENSMUSP00000044026","abundance":8.17,"rank":4510,"name":"Ovol2","annotation":"Transcription factor Ovo-like 2; Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1 (By similarity). Important for the correct development of primordial germ cells in embryos. Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000034856","abundance":8.17,"rank":4511,"name":"Mpi","annotation":"Mannose-6-phosphate isomerase; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions."},{"id":"ENSMUSP00000097097","abundance":8.16,"rank":4512,"name":"Ccdc80","annotation":"Coiled-coil domain-containing protein 80; Promotes cell adhesion and matrix assembly."},{"id":"ENSMUSP00000016951","abundance":8.16,"rank":4513,"name":"Serpinb1b","annotation":"Leukocyte elastase inhibitor B; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G. During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily."},{"id":"ENSMUSP00000010280","abundance":8.16,"rank":4514,"name":"Pifo","annotation":"Protein pitchfork; During primary cilia disassembly, involved in cilia disassembly. Required specifically to control cilia retraction as well as the liberation and duplication of the basal body/centrosome. May act by stimulating AURKA activity at the basal body in a cell cycle- dependent manner."},{"id":"ENSMUSP00000022634","abundance":8.16,"rank":4515,"name":"Bnip3l","annotation":"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; Induces apoptosis. Interacts with viral and cellular anti- apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIE [...] "},{"id":"ENSMUSP00000092539","abundance":8.15,"rank":4516,"name":"Gad1","annotation":"Glutamate decarboxylase 1; Catalyzes the production of GABA; Belongs to the group II decarboxylase family."},{"id":"ENSMUSP00000028286","abundance":8.15,"rank":4517,"name":"Agpat2","annotation":"1-acyl-sn-glycerol-3-phosphate acyltransferase beta; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone."},{"id":"ENSMUSP00000069692","abundance":8.14,"rank":4518,"name":"Them6","annotation":"Protein THEM6."},{"id":"ENSMUSP00000109484","abundance":8.14,"rank":4519,"name":"Ddx31","annotation":"Probable ATP-dependent RNA helicase DDX31; Probable ATP-dependent RNA helicase (By similarity). Plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1 (By similarity); Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily."},{"id":"ENSMUSP00000154005","abundance":8.14,"rank":4520,"name":"Mucl1","annotation":"Mucin-like 1."},{"id":"ENSMUSP00000109253","abundance":8.14,"rank":4521,"name":"Glb1l","annotation":"Beta-galactosidase-1-like protein; Probable glycosyl hydrolase."},{"id":"ENSMUSP00000018744","abundance":8.14,"rank":4522,"name":"Shmt1","annotation":"Serine hydroxymethyltransferase, cytosolic; Interconversion of serine and glycine."},{"id":"ENSMUSP00000033036","abundance":8.12,"rank":4523,"name":"Dkk3","annotation":"Dickkopf-related protein 3; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity); Belongs to the dickkopf family."},{"id":"ENSMUSP00000041118","abundance":8.12,"rank":4524,"name":"Foxa1","annotation":"Hepatocyte nuclear factor 3-alpha; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures [...] "},{"id":"ENSMUSP00000148273","abundance":8.12,"rank":4525,"name":"Cherp","annotation":"Calcium homeostasis endoplasmic reticulum protein; Involved in calcium homeostasis, growth and proliferation."},{"id":"ENSMUSP00000109640","abundance":8.11,"rank":4526,"name":"Cacfd1","annotation":"Calcium channel flower homolog; Belongs to the calcium channel flower family."},{"id":"ENSMUSP00000063284","abundance":8.11,"rank":4527,"name":"Arhgef33","annotation":"Rho guanine nucleotide exchange factor 33."},{"id":"ENSMUSP00000026486","abundance":8.1,"rank":4528,"name":"Katnal2","annotation":"Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays; Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily."},{"id":"ENSMUSP00000115539","abundance":8.1,"rank":4529,"name":"Gprin1","annotation":"G protein-regulated inducer of neurite outgrowth 1; May be involved in neurite outgrowth."},{"id":"ENSMUSP00000063839","abundance":8.1,"rank":4530,"name":"Adam10","annotation":"Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha- secretase cleavage of amyloid precursor protein (APP) at '687-Lys-|- Leu-688' (By similarity). Contributes to the normal cleavage of the cellula [...] "},{"id":"ENSMUSP00000155683","abundance":8.09,"rank":4531,"name":"Tfcp2","annotation":"Alpha-globin transcription factor CP2; Binds a variety of cellular promoters including fibrinogen, alpha-globin promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter (By similarity). Belongs to the grh/CP2 family. CP2 s [...] "},{"id":"ENSMUSP00000077733","abundance":8.09,"rank":4532,"name":"Dhps","annotation":"Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function."},{"id":"ENSMUSP00000007253","abundance":8.09,"rank":4533,"name":"Neu1","annotation":"Sialidase-1; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. Belongs to the glycosyl hydrolase 33 family."},{"id":"ENSMUSP00000118318","abundance":8.08,"rank":4534,"name":"Afdn","annotation":"Afadin; Belongs to an adhesion system, probably together with the E- cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs) (By similarity). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton (By similarity). May play a key role in the organization of epithelial structures of the embryonic ectoderm. Essential for the organization of adherens junctions (By similarity)."},{"id":"ENSMUSP00000088591","abundance":8.07,"rank":4535,"name":"Rraga","annotation":"Ras-related GTP-binding protein A; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death."},{"id":"ENSMUSP00000099539","abundance":8.07,"rank":4536,"name":"Cela2a","annotation":"Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily."},{"id":"ENSMUSP00000015581","abundance":8.05,"rank":4537,"name":"Gzmb","annotation":"Granzyme B(G,H); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity)."},{"id":"ENSMUSP00000030675","abundance":8.05,"rank":4538,"name":"Mrps15","annotation":"28S ribosomal protein S15, mitochondrial; Belongs to the universal ribosomal protein uS15 family."},{"id":"ENSMUSP00000028672","abundance":8.05,"rank":4539,"name":"Mdk","annotation":"Midkine; Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non- proteoglycan receptors. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration. Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflamma [...] "},{"id":"ENSMUSP00000020308","abundance":8.05,"rank":4540,"name":"Ddit4","annotation":"DNA damage-inducible transcript 4 protein; Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell typ [...] "},{"id":"ENSMUSP00000028854","abundance":8.05,"rank":4541,"name":"Mal","annotation":"Myelin and lymphocyte protein; Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Plays a role in the maintenance of the myelin sheath and in axon-glia and glia-glia interactions; Belongs to the MAL family."},{"id":"ENSMUSP00000092680","abundance":8.04,"rank":4542,"name":"Dnajc25","annotation":"DnaJ homolog subfamily C member 25; Belongs to the DNAJC25 family."},{"id":"ENSMUSP00000129031","abundance":8.04,"rank":4543,"name":"Dmkn","annotation":"Dermokine; May act as a soluble regulator of keratinocyte differentiation."},{"id":"ENSMUSP00000021676","abundance":8.04,"rank":4544,"name":"Erg28","annotation":"Ergosterol biosynthetic protein 28 homolog."},{"id":"ENSMUSP00000099715","abundance":8.04,"rank":4545,"name":"Pde1a","annotation":"Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP."},{"id":"ENSMUSP00000110440","abundance":8.03,"rank":4546,"name":"Fkbp5","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP5; Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1."},{"id":"ENSMUSP00000079703","abundance":8.03,"rank":4547,"name":"Amd2","annotation":"S-adenosylmethionine decarboxylase 2 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels; Belongs to the eukaryotic AdoMetDC family."},{"id":"ENSMUSP00000159133","abundance":8.03,"rank":4548,"name":"Amd1","annotation":"S-adenosylmethionine decarboxylase 1 alpha chain; Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels."},{"id":"ENSMUSP00000073102","abundance":8.03,"rank":4549,"name":"Afmid","annotation":"Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites."},{"id":"ENSMUSP00000028599","abundance":8.02,"rank":4550,"name":"Cstf3","annotation":"Cleavage stimulation factor subunit 3; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs."},{"id":"ENSMUSP00000133166","abundance":8.02,"rank":4551,"name":"Erap1","annotation":"Endoplasmic reticulum aminopeptidase 1; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play  [...] "},{"id":"ENSMUSP00000100725","abundance":8.02,"rank":4552,"name":"Foxd1","annotation":"Forkhead box protein D1; Transcription factor involved in regulation of gene expression in a variety of processes including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells. Involved in transcriptional activation of PGF and C3 genes (By similarity)."},{"id":"ENSMUSP00000151675","abundance":8.01,"rank":4553,"name":"Chchd10","annotation":"Coiled-coil-helix-coiled-coil-helix domain-containing 10."},{"id":"ENSMUSP00000100020","abundance":8,"rank":4554,"name":"Cetn4","annotation":"Centrin-4; Ca(2+)-binding protein that may be involved in basal body assembly or in a subsequent step of ciliogenesis."},{"id":"ENSMUSP00000126797","abundance":8,"rank":4555,"name":"Defa27","annotation":"Defensin, alpha, 27."},{"id":"ENSMUSP00000042762","abundance":7.99,"rank":4556,"name":"Pphln1","annotation":"Periphilin-1; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin. Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex. The HUSH complex is also involved in the silencing of unintegrated retrov [...] "},{"id":"ENSMUSP00000137225","abundance":7.98,"rank":4557,"name":"Tmsb15b2","annotation":"Thymosin beta 15b2."},{"id":"ENSMUSP00000118704","abundance":7.98,"rank":4558,"name":"Tmsb15l","annotation":"Thymosin beta 15b-like."},{"id":"ENSMUSP00000113488","abundance":7.97,"rank":4559,"name":"Pde4d","annotation":"cAMP-specific 3',5'-cyclic phosphodiesterase 4D; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily."},{"id":"ENSMUSP00000034723","abundance":7.97,"rank":4560,"name":"Aldh1a2","annotation":"Retinal dehydrogenase 2; Converts retinaldehyde to retinoic acid. Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal (By similarity). Lacks activity with benzaldehyde, acetaldehyde and octanal. Displays complete lack of activity with citral (By similarity)."},{"id":"ENSMUSP00000034713","abundance":7.97,"rank":4561,"name":"Ldlr","annotation":"Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits; Belongs to the LDLR family."},{"id":"ENSMUSP00000060129","abundance":7.96,"rank":4562,"name":"Themis","annotation":"Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk."},{"id":"ENSMUSP00000048002","abundance":7.96,"rank":4563,"name":"Hoxb4","annotation":"Homeobox protein Hox-B4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily."},{"id":"ENSMUSP00000095433","abundance":7.96,"rank":4564,"name":"Ubr4","annotation":"E3 ubiquitin-protein ligase UBR4; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin- mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degrad [...] "},{"id":"ENSMUSP00000132247","abundance":7.96,"rank":4565,"name":"Tex264","annotation":"Testis-expressed gene 264."},{"id":"ENSMUSP00000018476","abundance":7.96,"rank":4566,"name":"Stk3","annotation":"Serine/threonine-protein kinase 3 20kDa subunit; Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regul [...] "},{"id":"ENSMUSP00000064158","abundance":7.95,"rank":4567,"name":"Rpia","annotation":"Ribose-5-phosphate isomerase."},{"id":"ENSMUSP00000104234","abundance":7.94,"rank":4568,"name":"Ctdnep1","annotation":"CTD nuclear envelope phosphatase 1; Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and  [...] "},{"id":"ENSMUSP00000098631","abundance":7.94,"rank":4569,"name":"Jagn1","annotation":"Protein jagunal homolog 1; Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contri [...] "},{"id":"ENSMUSP00000113703","abundance":7.94,"rank":4570,"name":"Pxdn","annotation":"Peroxidasin homolog; Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system (By similarity). Plays a role in extracellular matrix formation."},{"id":"ENSMUSP00000030669","abundance":7.94,"rank":4571,"name":"Slc9a1","annotation":"Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction."},{"id":"ENSMUSP00000114092","abundance":7.94,"rank":4572,"name":"Tex35","annotation":"Testis-expressed protein 35."},{"id":"ENSMUSP00000001079","abundance":7.93,"rank":4573,"name":"Sec24b","annotation":"Sec24-related gene family, member B (S. cerevisiae)."},{"id":"ENSMUSP00000047199","abundance":7.93,"rank":4574,"name":"Gpc1","annotation":"Secreted glypican-1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting th [...] "},{"id":"ENSMUSP00000027366","abundance":7.93,"rank":4575,"name":"Vil1","annotation":"Villin-1; Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the inte [...] "},{"id":"ENSMUSP00000044049","abundance":7.93,"rank":4576,"name":"Tubgcp4","annotation":"Gamma-tubulin complex component 4; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome."},{"id":"ENSMUSP00000061126","abundance":7.93,"rank":4577,"name":"Cyp4a10","annotation":"Cytochrome P450 4A10; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000116259","abundance":7.93,"rank":4578,"name":"Srpk1","annotation":"SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] "},{"id":"ENSMUSP00000044517","abundance":7.93,"rank":4579,"name":"Tsc22d1","annotation":"TSC22 domain family protein 1; Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter; Belongs to the TSC-22/Dip/Bun family."},{"id":"ENSMUSP00000022494","abundance":7.93,"rank":4580,"name":"Ebpl","annotation":"Emopamil-binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands."},{"id":"ENSMUSP00000053122","abundance":7.92,"rank":4581,"name":"Pofut1","annotation":"GDP-fucose protein O-fucosyltransferase 1; Catalyzes the reaction that attaches fucose through an O- glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP- fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that ca [...] "},{"id":"ENSMUSP00000033502","abundance":7.92,"rank":4582,"name":"Gata1","annotation":"Erythroid transcription factor; Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (By similarity)."},{"id":"ENSMUSP00000137931","abundance":7.92,"rank":4583,"name":"Agrn","annotation":"Agrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. This neuron-specific (z+) isoform is a component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium [...] "},{"id":"ENSMUSP00000132688","abundance":7.91,"rank":4584,"name":"Cnppd1","annotation":"Protein CNPPD1."},{"id":"ENSMUSP00000078706","abundance":7.91,"rank":4585,"name":"Csnk1g2","annotation":"Casein kinase I isoform gamma-2; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand- dependent ubiquitination and subsequent [...] "},{"id":"ENSMUSP00000032920","abundance":7.91,"rank":4586,"name":"Cdipt","annotation":"CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity); Belongs to the CDP-alcohol phosphatidyltransferase class-I family."},{"id":"ENSMUSP00000091579","abundance":7.91,"rank":4587,"name":"Tbx6","annotation":"T-box transcription factor TBX6; T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia."},{"id":"ENSMUSP00000141991","abundance":7.91,"rank":4588,"name":"Osbpl9","annotation":"Oxysterol-binding protein-related protein 9."},{"id":"ENSMUSP00000030125","abundance":7.91,"rank":4589,"name":"Bag1","annotation":"BAG family molecular chaperone regulator 1; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate- binding domain (SBD) of HSPA8/HSC70. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death  [...] "},{"id":"ENSMUSP00000140414","abundance":7.9,"rank":4590,"name":"Atp5g2","annotation":"ATP synthase F(0) complex subunit C2, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanis [...] "},{"id":"ENSMUSP00000033901","abundance":7.9,"rank":4591,"name":"Naxd","annotation":"ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration."},{"id":"ENSMUSP00000048285","abundance":7.9,"rank":4592,"name":"Metap2","annotation":"Methionine aminopeptidase 2; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met- Ala-, Cys, Gly, Pro, Ser, Thr, or Val)."},{"id":"ENSMUSP00000048773","abundance":7.9,"rank":4593,"name":"Akap14","annotation":"A kinase (PRKA) anchor protein 14."},{"id":"ENSMUSP00000092992","abundance":7.89,"rank":4594,"name":"Ubxn8","annotation":"UBX domain-containing protein 8; Involved in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins, possibly by tethering VCP to the endoplasmic reticulum membrane. May play a role in reproduction (By similarity)."},{"id":"ENSMUSP00000033121","abundance":7.87,"rank":4595,"name":"Nomo1","annotation":"Nodal modulator 1; May antagonize Nodal signaling."},{"id":"ENSMUSP00000107387","abundance":7.87,"rank":4596,"name":"Tor1aip2","annotation":"Torsin-1A-interacting protein 2; Required for endoplasmic reticulum integrity. Regulates the distribution of TOR1A between the endoplasmic reticulum and the nuclear envelope as well as induces TOR1A, TOR1B and TOR3A ATPase activity (By similarity); Belongs to the TOR1AIP family."},{"id":"ENSMUSP00000001009","abundance":7.87,"rank":4597,"name":"Wfdc18","annotation":"WAP four-disulfide core domain protein 18; Could have proteinase inhibiting capacity."},{"id":"ENSMUSP00000076864","abundance":7.86,"rank":4598,"name":"Tfe3","annotation":"Transcription factor E3; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (By similarity). It also binds very well to a USF/MLTF site  [...] "},{"id":"ENSMUSP00000140676","abundance":7.86,"rank":4599,"name":"Rbp2","annotation":"Retinol-binding protein 2; Intracellular transport of retinol; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family."},{"id":"ENSMUSP00000099726","abundance":7.86,"rank":4600,"name":"Mog","annotation":"Myelin-oligodendrocyte glycoprotein; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. Belongs to the immunoglobulin superfamily. BTN/MOG family."},{"id":"ENSMUSP00000043768","abundance":7.85,"rank":4601,"name":"Cd81","annotation":"CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells. Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response (By similarity). In T cells, associates with CD4 or  [...] "},{"id":"ENSMUSP00000074549","abundance":7.85,"rank":4602,"name":"Unc13d","annotation":"Protein unc-13 homolog D; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis (By similarity). Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells."},{"id":"ENSMUSP00000098548","abundance":7.85,"rank":4603,"name":"Esyt2","annotation":"Extended synaptotagmin-2; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP- 2 complex (By similarity)."},{"id":"ENSMUSP00000016034","abundance":7.85,"rank":4604,"name":"Amdhd1","annotation":"Probable imidazolonepropionase."},{"id":"ENSMUSP00000031051","abundance":7.85,"rank":4605,"name":"Cgref1","annotation":"Cell growth regulator with EF hand domain protein 1; Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines (By similarity)."},{"id":"ENSMUSP00000129678","abundance":7.84,"rank":4606,"name":"Nrxn3","annotation":"Neurexin-3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity)."},{"id":"ENSMUSP00000099432","abundance":7.84,"rank":4607,"name":"Fbxl20","annotation":"F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Isoform 3 regulates neural transmission by binding and ubiquitinating RIMS1, a modulator of presynaptic plasticity."},{"id":"ENSMUSP00000114504","abundance":7.83,"rank":4608,"name":"Ttc38","annotation":"Tetratricopeptide repeat protein 38."},{"id":"ENSMUSP00000029938","abundance":7.83,"rank":4609,"name":"Gtf2b","annotation":"Transcription initiation factor IIB; General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II- TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter [...] "},{"id":"ENSMUSP00000116591","abundance":7.82,"rank":4610,"name":"Ccdc167","annotation":"Coiled-coil domain-containing protein 167."},{"id":"ENSMUSP00000003910","abundance":7.81,"rank":4611,"name":"Dnase2a","annotation":"Deoxyribonuclease-2-alpha; Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells. Belongs to the DNase II family."},{"id":"ENSMUSP00000031351","abundance":7.81,"rank":4612,"name":"Arl6ip4","annotation":"ADP-ribosylation factor-like protein 6-interacting protein 4; Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site; Belongs to the ARL6IP4 family."},{"id":"ENSMUSP00000075289","abundance":7.81,"rank":4613,"name":"Pex19","annotation":"Peroxisomal biogenesis factor 19; Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53."},{"id":"ENSMUSP00000131865","abundance":7.81,"rank":4614,"name":"Sla","annotation":"Src-like-adapter; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins."},{"id":"ENSMUSP00000014546","abundance":7.8,"rank":4615,"name":"Tsg101","annotation":"Tumor susceptibility gene 101 protein; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the  [...] "},{"id":"ENSMUSP00000109389","abundance":7.8,"rank":4616,"name":"H2-T24","annotation":"Histocompatibility 2, T region locus 24; Belongs to the MHC class I family."},{"id":"ENSMUSP00000124534","abundance":7.8,"rank":4617,"name":"Tmprss11e","annotation":"Transmembrane protease serine 11E non-catalytic chain; Serine protease which possesses both gelatinolytic and caseinolytic activities. Shows a preference for Arg in the P1 position. Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000003876","abundance":7.8,"rank":4618,"name":"Brd8","annotation":"Bromodomain-containing protein 8; May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Thi [...] "},{"id":"ENSMUSP00000025957","abundance":7.79,"rank":4619,"name":"Fam45a","annotation":"DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP- bound form."},{"id":"ENSMUSP00000084959","abundance":7.79,"rank":4620,"name":"Dera","annotation":"Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate. Participates in stress granule (SG) assembly. May allow ATP production from extracellular deoxyinosine in conditions of energy deprivation."},{"id":"ENSMUSP00000029542","abundance":7.79,"rank":4621,"name":"Ints3","annotation":"Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex."},{"id":"ENSMUSP00000041232","abundance":7.78,"rank":4622,"name":"Igsf8","annotation":"Immunoglobulin superfamily member 8; May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the  [...] "},{"id":"ENSMUSP00000022834","abundance":7.78,"rank":4623,"name":"Cma1","annotation":"Chymase; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion; Belongs to the peptidase S1 family. Granzyme subfamily."},{"id":"ENSMUSP00000027693","abundance":7.77,"rank":4624,"name":"Rab29","annotation":"Ras-related protein Rab-7L1; The small GTPases Rab are key regulators in vesicle trafficking (By similarity). Essential for maintaining the integrity of endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (By similarity). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Regulates also neuronal process morphology in the intact cen [...] "},{"id":"ENSMUSP00000078901","abundance":7.77,"rank":4625,"name":"Las1l","annotation":"Ribosomal biogenesis protein LAS1L; Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes; Belongs to the LAS1 family."},{"id":"ENSMUSP00000022976","abundance":7.77,"rank":4626,"name":"Washc5","annotation":"WASH complex subunit 5; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7 (By similarity). Involved in cyt [...] "},{"id":"ENSMUSP00000067598","abundance":7.77,"rank":4627,"name":"Gykl1","annotation":"Glycerol kinase-like 1; Belongs to the FGGY kinase family."},{"id":"ENSMUSP00000102724","abundance":7.77,"rank":4628,"name":"Plaa","annotation":"Phospholipase A-2-activating protein; Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium- independent phospholipase A2 activities in a tumor necrosis factor a [...] "},{"id":"ENSMUSP00000112727","abundance":7.77,"rank":4629,"name":"Bco2","annotation":"Beta,beta-carotene 9',10'-oxygenase; Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta- ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. Belongs to the carotenoid oxygenase family."},{"id":"ENSMUSP00000103271","abundance":7.77,"rank":4630,"name":"Gtf2h1","annotation":"General transcription factor IIH subunit 1; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] "},{"id":"ENSMUSP00000000260","abundance":7.76,"rank":4631,"name":"Gmpr","annotation":"GMP reductase 1; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides."},{"id":"ENSMUSP00000154293","abundance":7.76,"rank":4632,"name":"Ubr5","annotation":"E3 ubiquitin-protein ligase UBR5; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N- end rule, lea [...] "},{"id":"ENSMUSP00000099702","abundance":7.76,"rank":4633,"name":"Ube2l6","annotation":"Ubiquitin/ISG15-conjugating enzyme E2 L6; Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3."},{"id":"ENSMUSP00000068148","abundance":7.76,"rank":4634,"name":"Cpsf3","annotation":"Cleavage and polyadenylation specificity factor subunit 3; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as mRNA 3'- end-processing endonuclease. Also involved in the histone 3'-end pre- mRNA processing. U7 snRNP-dependent protein that induces both the 3' endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5'  [...] "},{"id":"ENSMUSP00000051215","abundance":7.76,"rank":4635,"name":"Hk3","annotation":"Hexokinase-3; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate; Belongs to the hexokinase family."},{"id":"ENSMUSP00000062628","abundance":7.76,"rank":4636,"name":"Lurap1l","annotation":"Leucine rich adaptor protein 1-like."},{"id":"ENSMUSP00000017622","abundance":7.76,"rank":4637,"name":"Zc3h18","annotation":"Zinc finger CCCH domain-containing protein 18."},{"id":"ENSMUSP00000116235","abundance":7.75,"rank":4638,"name":"Pkn1","annotation":"Serine/threonine-protein kinase N1; PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Se [...] "},{"id":"ENSMUSP00000119949","abundance":7.75,"rank":4639,"name":"Gatb","annotation":"Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily."},{"id":"ENSMUSP00000030791","abundance":7.74,"rank":4640,"name":"Smarcd3","annotation":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-spec [...] "},{"id":"ENSMUSP00000087524","abundance":7.73,"rank":4641,"name":"Gimap4","annotation":"GTPase IMAP family member 4; During thymocyte development, may play a role in the regulation of apoptosis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily."},{"id":"ENSMUSP00000075082","abundance":7.73,"rank":4642,"name":"Ap3s2","annotation":"AP-3 complex subunit sigma-2; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. Belongs to the adaptor complexes small subunit family."},{"id":"ENSMUSP00000029060","abundance":7.72,"rank":4643,"name":"Atp9a","annotation":"Probable phospholipid-transporting ATPase IIA."},{"id":"ENSMUSP00000113869","abundance":7.72,"rank":4644,"name":"Rph3al","annotation":"Rab effector Noc2; Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Regulates the exocytosis of dense-core vesicles in neuroendocrine cells through interaction with RAB27A. Acts as a potential RAB3B effector protein in epithelial cells."},{"id":"ENSMUSP00000138709","abundance":7.72,"rank":4645,"name":"Cox6b2","annotation":"Cytochrome c oxidase subunit 6B2; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and [...] "},{"id":"ENSMUSP00000069159","abundance":7.72,"rank":4646,"name":"Commd5","annotation":"COMM domain-containing protein 5; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B."},{"id":"ENSMUSP00000034863","abundance":7.71,"rank":4647,"name":"Csk","annotation":"Tyrosine-protein kinase CSK; Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C- terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins  [...] "},{"id":"ENSMUSP00000047376","abundance":7.71,"rank":4648,"name":"Gls2","annotation":"Glutaminase liver isoform, mitochondrial; Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation."},{"id":"ENSMUSP00000007207","abundance":7.7,"rank":4649,"name":"Clcn2","annotation":"Chloride channel protein 2; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport (By similarity). Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization, activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase, the rate-limiting enzyme for aldosterone biosynthesis (By similarity); Belongs  [...] "},{"id":"ENSMUSP00000003681","abundance":7.7,"rank":4650,"name":"Sec14l2","annotation":"SEC14-like protein 2; Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha- tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity)."},{"id":"ENSMUSP00000032089","abundance":7.7,"rank":4651,"name":"Reg3g","annotation":"Regenerating islet-derived protein 3-gamma 16.5 kDa form; Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. The uncleaved form has bacteriostatic activity, whereas the cleaved form has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. Regulates keratinocyte proliferation and [...] "},{"id":"ENSMUSP00000044253","abundance":7.69,"rank":4652,"name":"Chchd5","annotation":"Coiled-coil-helix-coiled-coil-helix domain-containing protein 5."},{"id":"ENSMUSP00000075687","abundance":7.69,"rank":4653,"name":"Gria3","annotation":"Glutamate receptor 3; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of  [...] "},{"id":"ENSMUSP00000113499","abundance":7.68,"rank":4654,"name":"Fuca2","annotation":"Plasma alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family."},{"id":"ENSMUSP00000110128","abundance":7.68,"rank":4655,"name":"Osgepl1","annotation":"Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. Belongs to the KAE1 / TsaD family."},{"id":"ENSMUSP00000033241","abundance":7.67,"rank":4656,"name":"Lhpp","annotation":"Phospholysine phosphohistidine inorganic pyrophosphate phosphatase; Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity); Belongs to the HAD-like hydrolase superfamily."},{"id":"ENSMUSP00000075167","abundance":7.67,"rank":4657,"name":"Abl1","annotation":"Tyrosine-protein kinase ABL1; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-bindin [...] "},{"id":"ENSMUSP00000044533","abundance":7.67,"rank":4658,"name":"Zbed5","annotation":"Zinc finger, BED type-containing 5."},{"id":"ENSMUSP00000027491","abundance":7.67,"rank":4659,"name":"Agxt","annotation":"Serine--pyruvate aminotransferase, mitochondrial; Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes)."},{"id":"ENSMUSP00000001109","abundance":7.66,"rank":4660,"name":"Mfsd10","annotation":"Major facilitator superfamily domain-containing protein 10; Confers cellular resistance to apoptosis induced by the non- steroidal anti-inflammatory drugs indomethacin and diclofenac. May act as an efflux pump (By similarity); Belongs to the major facilitator superfamily."},{"id":"ENSMUSP00000112751","abundance":7.66,"rank":4661,"name":"Pomgnt1","annotation":"Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1; Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose. Belongs to the glycosyltransferase 13 family."},{"id":"ENSMUSP00000072008","abundance":7.66,"rank":4662,"name":"Pdcd11","annotation":"Protein RRP5 homolog; Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity)."},{"id":"ENSMUSP00000089664","abundance":7.66,"rank":4663,"name":"Rbms2","annotation":"RNA-binding motif, single-stranded-interacting protein 2."},{"id":"ENSMUSP00000032429","abundance":7.66,"rank":4664,"name":"Med21","annotation":"Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000124264","abundance":7.65,"rank":4665,"name":"Aptx","annotation":"Aprataxin; DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'- monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), b [...] "},{"id":"ENSMUSP00000105250","abundance":7.65,"rank":4666,"name":"Tox3","annotation":"TOX high mobility group box family member 3; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen- responsive C3 promoter region (By similarity)."},{"id":"ENSMUSP00000010348","abundance":7.65,"rank":4667,"name":"Fdx2","annotation":"Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family."},{"id":"ENSMUSP00000105183","abundance":7.65,"rank":4668,"name":"Ogfod1","annotation":"Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro- 62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation."},{"id":"ENSMUSP00000113806","abundance":7.65,"rank":4669,"name":"Papln","annotation":"Papilin."},{"id":"ENSMUSP00000024763","abundance":7.65,"rank":4670,"name":"Mrps18a","annotation":"28S ribosomal protein S18a, mitochondrial; Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mL66 subfamily."},{"id":"ENSMUSP00000034904","abundance":7.64,"rank":4671,"name":"Elovl5","annotation":"Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] "},{"id":"ENSMUSP00000034983","abundance":7.64,"rank":4672,"name":"Atp1b3","annotation":"Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known."},{"id":"ENSMUSP00000032371","abundance":7.64,"rank":4673,"name":"Gys2","annotation":"Glycogen [starch] synthase, liver; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan; Belongs to the glycosyltransferase 3 family."},{"id":"ENSMUSP00000079627","abundance":7.64,"rank":4674,"name":"Zc3hc1","annotation":"Nuclear-interacting partner of ALK; Essential component of a SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry (By similarity). Overexpression may be able to protect from apoptosis induced by IL-3 withdrawal."},{"id":"ENSMUSP00000021802","abundance":7.63,"rank":4675,"name":"Cap2","annotation":"Adenylyl cyclase-associated protein 2; May have a regulatory bifunctional role; Belongs to the CAP family."},{"id":"ENSMUSP00000080683","abundance":7.63,"rank":4676,"name":"Mpp5","annotation":"MAGUK p55 subfamily member 5; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface. Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development. Required for the maintenance of cerebell [...] "},{"id":"ENSMUSP00000032471","abundance":7.62,"rank":4677,"name":"Rho","annotation":"Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling."},{"id":"ENSMUSP00000018568","abundance":7.62,"rank":4678,"name":"Drg2","annotation":"Developmentally-regulated GTP-binding protein 2; Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. When hydroxylated at C-3 of 'Lys-21' by JMJD7, may bind to RNA and play a role in translation. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family."},{"id":"ENSMUSP00000106995","abundance":7.62,"rank":4679,"name":"ENSMUSP00000106995","annotation":"annotation not available"},{"id":"ENSMUSP00000111594","abundance":7.62,"rank":4680,"name":"ENSMUSP00000111594","annotation":"annotation not available"},{"id":"ENSMUSP00000099894","abundance":7.61,"rank":4681,"name":"Mpdz","annotation":"Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity)."},{"id":"ENSMUSP00000021670","abundance":7.61,"rank":4682,"name":"Ylpm1","annotation":"YLP motif-containing protein 1."},{"id":"ENSMUSP00000033133","abundance":7.61,"rank":4683,"name":"Rgs10","annotation":"Regulator of G-protein signaling 10; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to CHRM2 signaling. Activity on GNAZ is inhibited by palmitoylation of the G-protein."},{"id":"ENSMUSP00000115934","abundance":7.59,"rank":4684,"name":"Dhodh","annotation":"Dihydroorotate dehydrogenase (quinone), mitochondrial; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor."},{"id":"ENSMUSP00000138219","abundance":7.59,"rank":4685,"name":"Sbp","annotation":"Prostatic spermine-binding protein; This protein seems to be functional equivalent to rat prostatic spermine-binding protein, which is involved in polyamine binding."},{"id":"ENSMUSP00000029846","abundance":7.59,"rank":4686,"name":"Ccn1","annotation":"CCN family member 1; Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CCN1-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive s [...] "},{"id":"ENSMUSP00000049977","abundance":7.59,"rank":4687,"name":"Slk","annotation":"STE20-like serine/threonine-protein kinase; Mediates apoptosis and actin stress fiber dissolution."},{"id":"ENSMUSP00000145012","abundance":7.58,"rank":4688,"name":"Gm44596","annotation":"Predicted gene 44596."},{"id":"ENSMUSP00000038225","abundance":7.58,"rank":4689,"name":"Pip5k1c","annotation":"Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma; Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5- trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4- phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as vesicle mediated transpo [...] "},{"id":"ENSMUSP00000076090","abundance":7.58,"rank":4690,"name":"Iah1","annotation":"Isoamyl acetate-hydrolyzing esterase 1 homolog; Probable lipase."},{"id":"ENSMUSP00000012259","abundance":7.58,"rank":4691,"name":"Med15","annotation":"Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol [...] "},{"id":"ENSMUSP00000036025","abundance":7.58,"rank":4692,"name":"Pgm5","annotation":"Phosphoglucomutase-like protein 5; Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity (By similarity). Belongs to the phosphohexose mutase family."},{"id":"ENSMUSP00000127611","abundance":7.58,"rank":4693,"name":"Aqp5","annotation":"Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands. Belongs to the MIP/aquaporin (TC 1.A.8) family."},{"id":"ENSMUSP00000030860","abundance":7.58,"rank":4694,"name":"Mad2l2","annotation":"Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks  [...] "},{"id":"ENSMUSP00000017147","abundance":7.57,"rank":4695,"name":"Svs3a","annotation":"Seminal vesicle secretory protein 3A; Component of the copulatory plug."},{"id":"ENSMUSP00000083222","abundance":7.57,"rank":4696,"name":"Piwil1","annotation":"Piwi-like protein 1; Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived fr [...] "},{"id":"ENSMUSP00000080081","abundance":7.57,"rank":4697,"name":"Fxn","annotation":"Frataxin intermediate form; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 (By similarity); Belongs to the frataxin family."},{"id":"ENSMUSP00000025714","abundance":7.57,"rank":4698,"name":"Rpp30","annotation":"Ribonuclease P protein subunit p30; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the eukaryotic/archaeal RNase P protein component 3 family."},{"id":"ENSMUSP00000051579","abundance":7.56,"rank":4699,"name":"Col9a1","annotation":"Collagen alpha-1(IX) chain; Structural component of hyaline cartilage and vitreous of the eye."},{"id":"ENSMUSP00000019302","abundance":7.56,"rank":4700,"name":"Tmem160","annotation":"Transmembrane protein 160."},{"id":"ENSMUSP00000152220","abundance":7.55,"rank":4701,"name":"Eipr1","annotation":"EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex."},{"id":"ENSMUSP00000050940","abundance":7.55,"rank":4702,"name":"Exosc4","annotation":"Exosome complex component RRP41; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] "},{"id":"ENSMUSP00000039334","abundance":7.55,"rank":4703,"name":"Diaph2","annotation":"Protein diaphanous homolog 2; May be involved in oogenesis; Belongs to the formin homology family. Diaphanous subfamily."},{"id":"ENSMUSP00000034052","abundance":7.54,"rank":4704,"name":"Anxa10","annotation":"Annexin A10; Belongs to the annexin family."},{"id":"ENSMUSP00000022203","abundance":7.54,"rank":4705,"name":"Dimt1","annotation":"Probable dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity."},{"id":"ENSMUSP00000039368","abundance":7.53,"rank":4706,"name":"Ptprf","annotation":"Receptor-type tyrosine-protein phosphatase F; Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily."},{"id":"ENSMUSP00000151555","abundance":7.53,"rank":4707,"name":"Slc10a1","annotation":"Sodium/bile acid cotransporter; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family."},{"id":"ENSMUSP00000028603","abundance":7.53,"rank":4708,"name":"Fbxo3","annotation":"F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity)."},{"id":"ENSMUSP00000128915","abundance":7.53,"rank":4709,"name":"Mrpl16","annotation":"39S ribosomal protein L16, mitochondrial; Belongs to the universal ribosomal protein uL16 family."},{"id":"ENSMUSP00000038590","abundance":7.52,"rank":4710,"name":"Tcp11","annotation":"T-complex protein 11; Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway ; Belongs to the TCP11 family."},{"id":"ENSMUSP00000032485","abundance":7.51,"rank":4711,"name":"Mrpl51","annotation":"39S ribosomal protein L51, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL51 family."},{"id":"ENSMUSP00000029053","abundance":7.51,"rank":4712,"name":"Ptpn1","annotation":"Tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c- src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). Belongs to th [...] "},{"id":"ENSMUSP00000030693","abundance":7.51,"rank":4713,"name":"Fgr","annotation":"Tyrosine-protein kinase Fgr; Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downs [...] "},{"id":"ENSMUSP00000023396","abundance":7.51,"rank":4714,"name":"Pmm2","annotation":"Phosphomannomutase 2; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions."},{"id":"ENSMUSP00000140024","abundance":7.51,"rank":4715,"name":"Serpina3a","annotation":"Serine protease inhibitor A3A; Belongs to the serpin family."},{"id":"ENSMUSP00000019721","abundance":7.51,"rank":4716,"name":"Pdk4","annotation":"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonge [...] "},{"id":"ENSMUSP00000146310","abundance":7.5,"rank":4717,"name":"Rnf40","annotation":"E3 ubiquitin-protein ligase BRE1B; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradic [...] "},{"id":"ENSMUSP00000081369","abundance":7.49,"rank":4718,"name":"Cyp4a32","annotation":"Cytochrome P450, family 4, subfamily a, polypeptide 32; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000022614","abundance":7.49,"rank":4719,"name":"Ccdc25","annotation":"Coiled-coil domain-containing protein 25; Belongs to the CCDC25 family."},{"id":"ENSMUSP00000022245","abundance":7.49,"rank":4720,"name":"Mrps30","annotation":"28S ribosomal protein S30, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL65 family."},{"id":"ENSMUSP00000132603","abundance":7.49,"rank":4721,"name":"Gbe1","annotation":"1,4-alpha-glucan-branching enzyme; Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule."},{"id":"ENSMUSP00000081946","abundance":7.48,"rank":4722,"name":"Ubp1","annotation":"Upstream-binding protein 1; Functions as a transcriptional activator in a promoter context-dependent manner. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Functions as a trans-acting factor that regulates the domestic strain CYP2D9 gene through specific association with the regulatory element SDI-A1. Binding to SDI-A1 depends on the type of nucleotide at position 299; binding is abolished by a nucleotide substitution at this position. Modulates the placental expre [...] "},{"id":"ENSMUSP00000037454","abundance":7.48,"rank":4723,"name":"Npl","annotation":"N-acetylneuraminate lyase; Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway."},{"id":"ENSMUSP00000081636","abundance":7.48,"rank":4724,"name":"Cln3","annotation":"Battenin; Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes."},{"id":"ENSMUSP00000136467","abundance":7.47,"rank":4725,"name":"Ddc","annotation":"Aromatic-L-amino-acid decarboxylase; Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine; Belongs to the group II decarboxylase family."},{"id":"ENSMUSP00000102877","abundance":7.47,"rank":4726,"name":"Rab38","annotation":"Ras-related protein Rab-38; Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium (By similarity). May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7. Plays an important role in the control of melanin production and melanosome biogenesis (By similarity). In concert with RAB32, regulates the proper trafficking of mel [...] "},{"id":"ENSMUSP00000074258","abundance":7.47,"rank":4727,"name":"Serpina11","annotation":"Serpin A11."},{"id":"ENSMUSP00000035167","abundance":7.46,"rank":4728,"name":"Nphp3","annotation":"Nephrocystin-3; Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements."},{"id":"ENSMUSP00000029875","abundance":7.46,"rank":4729,"name":"Pip4p2","annotation":"Type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylino [...] "},{"id":"ENSMUSP00000004203","abundance":7.46,"rank":4730,"name":"Ppan","annotation":"Suppressor of SWI4 1 homolog; May have a role in cell growth."},{"id":"ENSMUSP00000120365","abundance":7.45,"rank":4731,"name":"Ndc1","annotation":"Nucleoporin NDC1; Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity); Belongs to the NDC1 family."},{"id":"ENSMUSP00000044371","abundance":7.45,"rank":4732,"name":"Hsdl1","annotation":"Inactive hydroxysteroid dehydrogenase-like protein 1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily."},{"id":"ENSMUSP00000108296","abundance":7.44,"rank":4733,"name":"Zbtb14","annotation":"Zinc finger and BTB domain-containing protein 14; Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA- 3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene (By similarity). Transcriptional repressor of MYC and thymidine kinase promoters."},{"id":"ENSMUSP00000115672","abundance":7.44,"rank":4734,"name":"Aamdc","annotation":"Mth938 domain-containing protein; May play a role in preadipocyte differentiation and adipogenesis; Belongs to the AAMDC family."},{"id":"ENSMUSP00000102891","abundance":7.44,"rank":4735,"name":"Pogz","annotation":"Pogo transposable element with ZNF domain; Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (By similarity)."},{"id":"ENSMUSP00000027871","abundance":7.44,"rank":4736,"name":"Sell","annotation":"L-selectin; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity)."},{"id":"ENSMUSP00000103448","abundance":7.43,"rank":4737,"name":"Ankrd40","annotation":"Ankyrin repeat domain-containing protein 40."},{"id":"ENSMUSP00000158988","abundance":7.42,"rank":4738,"name":"Apof","annotation":"Apolipoprotein F; Minor apolipoprotein that associates with LDL. Inhibits cholesteryl ester transfer protein (CETP) activity and appears to be an important regulator of cholesterol transport. Also associates to a lesser degree with VLDL, Apo-AI and Apo-AII."},{"id":"ENSMUSP00000072732","abundance":7.42,"rank":4739,"name":"Sirt2","annotation":"NAD-dependent protein deacetylase sirtuin-2; NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and alpha-tubulin as well as many other proteins such as key transcription factors. Participates in the modulation of multiple and diverse biological processes such as cell cycle control, genomic integrity, microtubule dynamics, cell differentiation, metabolic networks, and autophagy. Plays a major role in the control of cell cycle progression and genomic stability. Functions in the antephase checkpoint preventing precocious mitotic entry in response to microtu [...] "},{"id":"ENSMUSP00000030434","abundance":7.41,"rank":4740,"name":"Fuca1","annotation":"Tissue alpha-L-fucosidase; Alpha-L-fucosidase is responsible for hydrolyzing the alpha- 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins; Belongs to the glycosyl hydrolase 29 family."},{"id":"ENSMUSP00000099708","abundance":7.41,"rank":4741,"name":"Oxct2b","annotation":"Succinyl-CoA:3-ketoacid coenzyme A transferase 2B, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa; Belongs to the 3-oxoacid CoA-transferase family."},{"id":"ENSMUSP00000069578","abundance":7.41,"rank":4742,"name":"Npm3","annotation":"Nucleoplasmin-3; Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning. Modulates the histone chaperone function and the RNA- binding activity of nucleolar phosphoprotein B23/NPM. Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM."},{"id":"ENSMUSP00000099217","abundance":7.4,"rank":4743,"name":"Gm10491","annotation":"Predicted gene 10491."},{"id":"ENSMUSP00000141107","abundance":7.4,"rank":4744,"name":"Mtln","annotation":"Mitoregulin; Positively regulates mitochondrial complex assembly and/or stability. Increases mitochondrial membrane potential and mitochondrial respiration rate while decreasing mitochondrial reactive oxygen species (By similarity). Also increases mitochondrial calcium retention capacity. Belongs to the mitoregulin family."},{"id":"ENSMUSP00000147920","abundance":7.39,"rank":4745,"name":"Folr2","annotation":"Folate receptor beta; Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity)."},{"id":"ENSMUSP00000025506","abundance":7.39,"rank":4746,"name":"Rbm22","annotation":"Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses; Belongs to the SLT11 family."},{"id":"ENSMUSP00000031090","abundance":7.39,"rank":4747,"name":"Sel1l3","annotation":"Protein sel-1 homolog 3."},{"id":"ENSMUSP00000103912","abundance":7.39,"rank":4748,"name":"Tnfaip1","annotation":"BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA- dependent DNA polymerase delta activity (By similarity)."},{"id":"ENSMUSP00000031508","abundance":7.39,"rank":4749,"name":"Triap1","annotation":"TP53-regulated inhibitor of apoptosis 1; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter acros [...] "},{"id":"ENSMUSP00000099700","abundance":7.38,"rank":4750,"name":"Oxct2a","annotation":"Succinyl-CoA:3-ketoacid coenzyme A transferase 2A, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). Probably play and important roles in the energy metabolism of spermatozoa."},{"id":"ENSMUSP00000087119","abundance":7.38,"rank":4751,"name":"Mmp14","annotation":"Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7 (By similarity). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues (By similarity). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (By si [...] "},{"id":"ENSMUSP00000002518","abundance":7.37,"rank":4752,"name":"Tle5","annotation":"TLE family member 5; Transcriptional corepressor. Acts as dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development."},{"id":"ENSMUSP00000034313","abundance":7.37,"rank":4753,"name":"Ntpcr","annotation":"Cancer-related nucleoside-triphosphatase homolog; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (By similarity)."},{"id":"ENSMUSP00000090374","abundance":7.37,"rank":4754,"name":"Krtap3-3","annotation":"Keratin associated protein 3-3."},{"id":"ENSMUSP00000090373","abundance":7.37,"rank":4755,"name":"Krtap3-2","annotation":"Keratin-associated protein 3-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the KRTAP type 3 family."},{"id":"ENSMUSP00000053940","abundance":7.37,"rank":4756,"name":"Krtap3-1","annotation":"Keratin-associated protein 3-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the KRTAP type 3 family."},{"id":"ENSMUSP00000111093","abundance":7.36,"rank":4757,"name":"Ap1m2","annotation":"AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules."},{"id":"ENSMUSP00000032262","abundance":7.36,"rank":4758,"name":"Clec1b","annotation":"C-type lectin domain family 1 member B; C-type lectin-like receptor that functions as a platelet receptor for the lymphatic endothelial marker, PDPN. After ligand activation, signals via sequential activation of SRC and SYK tyrosine kinases leading to activation of PLCG2."},{"id":"ENSMUSP00000020241","abundance":7.36,"rank":4759,"name":"Pah","annotation":"Phenylalanine-4-hydroxylase; Catalyzes the hydroxylation of L-phenylalanine to L-tyrosine. Belongs to the biopterin-dependent aromatic amino acid hydroxylase family."},{"id":"ENSMUSP00000079025","abundance":7.36,"rank":4760,"name":"Rnase1","annotation":"Ribonuclease pancreatic; Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA (By similarity); Belongs to the pancreatic ribonuclease family."},{"id":"ENSMUSP00000029017","abundance":7.35,"rank":4761,"name":"Pck1","annotation":"Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Regulates cataplerosis and anaplerosis, the processes that control the levels of metabolic intermediates in the citric acid cycle. At low glucose levels, it catalyzes the cataplerotic conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. At high glucose levels, it catalyzes the anaplerotic conversion of phosphoenolpyruvate to oxaloacetate; Belongs to the phosphoenolpyruvate carboxykinase  [...] "},{"id":"ENSMUSP00000020578","abundance":7.34,"rank":4762,"name":"Nudcd2","annotation":"NudC domain-containing protein 2; May regulate the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone."},{"id":"ENSMUSP00000113726","abundance":7.34,"rank":4763,"name":"Il4i1","annotation":"L-amino-acid oxidase; Lysosomal L-amino-acid oxidase with highest specific activity with phenylalanine. May play a role in lysosomal antigen processing and presentation; Belongs to the flavin monoamine oxidase family. FIG1 subfamily."},{"id":"ENSMUSP00000069549","abundance":7.34,"rank":4764,"name":"Rock1","annotation":"Rho-associated protein kinase 1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By simi [...] "},{"id":"ENSMUSP00000099677","abundance":7.34,"rank":4765,"name":"Adprhl2","annotation":"ADP-ribose glycohydrolase ARH3; ADP-ribose glycohydrolase that preferentially hydrolyzes the scissile alpha-O-linkage attached to the anomeric C1'' position of ADP- ribose and acts on different substrates, such as proteins ADP- ribosylated on serine, free poly(ADP-ribose) and O-acetyl-ADP-D-ribose (By similarity). Specifically acts as a serine mono-ADP- ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to serine residues on proteins, thereby playing a key role in DNA damage response (By similarity). Serine ADP-ribosylation of proteins constitutes the primary form of [...] "},{"id":"ENSMUSP00000157269","abundance":7.33,"rank":4766,"name":"Proc","annotation":"Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000117636","abundance":7.32,"rank":4767,"name":"Ccbe1","annotation":"Collagen and calcium-binding EGF domain-containing protein 1; Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis; Belongs to the CCBE1 family."},{"id":"ENSMUSP00000025786","abundance":7.32,"rank":4768,"name":"Pacs1","annotation":"Phosphofurin acidic cluster sorting protein 1; Coat protein that is involved in the localization of trans- Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster- containing cytoplasmic domain of these molecules with the adapter- protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits (By similarity)."},{"id":"ENSMUSP00000026455","abundance":7.32,"rank":4769,"name":"Mip","annotation":"Lens fiber major intrinsic protein; Water channel. Channel activity is down-regulated by CALM when cytoplasmic Ca(2+) levels are increased. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. Plays a role in cell-to-cell adhesion and facilitates gap junction coupling (By similarity). Belongs to the MIP/aquaporin (TC 1.A.8) family."},{"id":"ENSMUSP00000088532","abundance":7.32,"rank":4770,"name":"Dab2ip","annotation":"Disabled homolog 2-interacting protein; Functions as a scaffold protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Involved in several processes such as innate immune response, inflammation and cell growth inhibition, apoptosis, cell survival, angiogenesis, cell migration and maturation. Plays also a role in cell cycle checkpoint control; reduces G1 phase cyclin levels resulting in G0/G1 cell cycle arrest. Mediates signal transduction by receptor- mediated inflammatory signals, such as the tumor necrosis factor (TNF), interferon [...] "},{"id":"ENSMUSP00000094943","abundance":7.32,"rank":4771,"name":"Gm6034","annotation":"Predicted gene 6034."},{"id":"ENSMUSP00000072509","abundance":7.31,"rank":4772,"name":"Wdr7","annotation":"WD repeat-containing protein 7."},{"id":"ENSMUSP00000102745","abundance":7.31,"rank":4773,"name":"Myo7a","annotation":"Unconventional myosin-VIIa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina [...] "},{"id":"ENSMUSP00000031531","abundance":7.3,"rank":4774,"name":"Psmg3","annotation":"Proteasome assembly chaperone 3; Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes; Belongs to the PSMG3 family."},{"id":"ENSMUSP00000021197","abundance":7.29,"rank":4775,"name":"Blmh","annotation":"Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000049823","abundance":7.28,"rank":4776,"name":"Iba57","annotation":"Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily."},{"id":"ENSMUSP00000150318","abundance":7.28,"rank":4777,"name":"Parp16","annotation":"Protein mono-ADP-ribosyltransferase PARP16; Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP- ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases."},{"id":"ENSMUSP00000005336","abundance":7.28,"rank":4778,"name":"Senp3","annotation":"Sentrin-specific protease 3; Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin. Plays a role in the regulation of sumoylation status of ZNF148. Func [...] "},{"id":"ENSMUSP00000066891","abundance":7.27,"rank":4779,"name":"Lnpk","annotation":"Endoplasmic reticulum junction formation protein lunapark; Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network. May be involved in limb and central nervous system development. Belongs to the lunapark family."},{"id":"ENSMUSP00000045214","abundance":7.27,"rank":4780,"name":"Ano10","annotation":"Anoctamin-10; Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1 (By similarity). Belongs to the anoctamin family."},{"id":"ENSMUSP00000088796","abundance":7.26,"rank":4781,"name":"Sec16a","annotation":"Protein transport protein Sec16A; Acts as a molecular scaffold that plays a key role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Mediates the recruitment of MIA3/TANGO to ERES. Regulates both conventional (ER/Golgi-dependent) and GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell mem [...] "},{"id":"ENSMUSP00000147553","abundance":7.26,"rank":4782,"name":"Pde2a","annotation":"cGMP-dependent 3',5'-cyclic phosphodiesterase; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes."},{"id":"ENSMUSP00000106897","abundance":7.26,"rank":4783,"name":"Trp53i11","annotation":"Tumor protein p53-inducible protein 11."},{"id":"ENSMUSP00000024492","abundance":7.25,"rank":4784,"name":"Acbd4","annotation":"Acyl-Coenzyme A-binding domain-containing 4."},{"id":"ENSMUSP00000105179","abundance":7.25,"rank":4785,"name":"Rasa1","annotation":"RAS p21 protein activator 1."},{"id":"ENSMUSP00000047630","abundance":7.25,"rank":4786,"name":"Gpr19","annotation":"Probable G-protein coupled receptor 19; Orphan receptor."},{"id":"ENSMUSP00000043488","abundance":7.24,"rank":4787,"name":"Xpot","annotation":"Exportin-T; Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nucl [...] "},{"id":"ENSMUSP00000034470","abundance":7.24,"rank":4788,"name":"Vps26b","annotation":"Vacuolar protein sorting-associated protein 26B; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for carg [...] "},{"id":"ENSMUSP00000076459","abundance":7.24,"rank":4789,"name":"Sgcd","annotation":"Delta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix."},{"id":"ENSMUSP00000136781","abundance":7.23,"rank":4790,"name":"Rbm31y","annotation":"RNA-binding motif 31, Y-linked."},{"id":"ENSMUSP00000084582","abundance":7.23,"rank":4791,"name":"Pgm2","annotation":"Phosphoglucomutase-2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5- phosphopentoses. May also catalyze the interconversion of glucose-1- phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity (By similarity); Belongs to the phosphohexose mutase family."},{"id":"ENSMUSP00000089540","abundance":7.23,"rank":4792,"name":"Rbm27","annotation":"RNA-binding protein 27."},{"id":"ENSMUSP00000142770","abundance":7.22,"rank":4793,"name":"Fdps","annotation":"Farnesyl pyrophosphate synthase; Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity)."},{"id":"ENSMUSP00000018988","abundance":7.22,"rank":4794,"name":"Fndc8","annotation":"Fibronectin type III domain-containing protein 8."},{"id":"ENSMUSP00000070405","abundance":7.22,"rank":4795,"name":"Tmem143","annotation":"Transmembrane protein 143."},{"id":"ENSMUSP00000017255","abundance":7.22,"rank":4796,"name":"Krt24","annotation":"Keratin, type I cytoskeletal 24; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000066546","abundance":7.22,"rank":4797,"name":"Plekha2","annotation":"Pleckstrin homology domain-containing family A member 2; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane."},{"id":"ENSMUSP00000083426","abundance":7.21,"rank":4798,"name":"Aurkc","annotation":"Aurora kinase C; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphoryla [...] "},{"id":"ENSMUSP00000020022","abundance":7.21,"rank":4799,"name":"Smpdl3a","annotation":"Acid sphingomyelinase-like phosphodiesterase 3a; Has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity (By similarity)."},{"id":"ENSMUSP00000031249","abundance":7.21,"rank":4800,"name":"Sparcl1","annotation":"SPARC-like protein 1; Belongs to the SPARC family."},{"id":"ENSMUSP00000022121","abundance":7.2,"rank":4801,"name":"Zcchc9","annotation":"Zinc finger CCHC domain-containing protein 9; May down-regulate transcription mediated by NF-kappa-B and the serum response element."},{"id":"ENSMUSP00000035230","abundance":7.2,"rank":4802,"name":"Amt","annotation":"Aminomethyltransferase, mitochondrial; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family."},{"id":"ENSMUSP00000025968","abundance":7.2,"rank":4803,"name":"Cyp2c39","annotation":"Cytochrome P450 2C39; Metabolizes arachidonic acid to produce 14,15-cis- epoxyeicosatrienoic acid (EET); Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000017604","abundance":7.2,"rank":4804,"name":"Cyba","annotation":"Cytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. Belongs to the p22phox family."},{"id":"ENSMUSP00000000253","abundance":7.2,"rank":4805,"name":"Lhx2","annotation":"LIM/homeobox protein Lhx2; Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types."},{"id":"ENSMUSP00000029909","abundance":7.19,"rank":4806,"name":"Coq3","annotation":"Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family."},{"id":"ENSMUSP00000130693","abundance":7.19,"rank":4807,"name":"Ccne2","annotation":"G1/S-specific cyclin-E2; Essential for the control of the cell cycle at the late G1 and early S phase."},{"id":"ENSMUSP00000126531","abundance":7.18,"rank":4808,"name":"Arih1","annotation":"E3 ubiquitin-protein ligase ARIH1; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets. The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2. E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin- [...] "},{"id":"ENSMUSP00000099645","abundance":7.18,"rank":4809,"name":"Fgf11","annotation":"Fibroblast growth factor 11; Probably involved in nervous system development and function."},{"id":"ENSMUSP00000137746","abundance":7.18,"rank":4810,"name":"Ascl5","annotation":"Achaete-scute family bHLH transcription factor 5."},{"id":"ENSMUSP00000027534","abundance":7.18,"rank":4811,"name":"Ilkap","annotation":"Integrin-linked kinase-associated serine/threonine phosphatase 2C; Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation (By similarity)."},{"id":"ENSMUSP00000135831","abundance":7.18,"rank":4812,"name":"Atpaf1","annotation":"ATP synthase mitochondrial F1 complex assembly factor 1; May play an essential role for the assembly of the mitochondrial F1-F0 complex; Belongs to the ATP11 family."},{"id":"ENSMUSP00000073519","abundance":7.17,"rank":4813,"name":"Gm11562","annotation":"Predicted gene 11562."},{"id":"ENSMUSP00000055277","abundance":7.17,"rank":4814,"name":"Yars2","annotation":"Tyrosine--tRNA ligase, mitochondrial; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000088493","abundance":7.16,"rank":4815,"name":"Nes","annotation":"Nestin; Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division (By similarity). Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells."},{"id":"ENSMUSP00000112340","abundance":7.16,"rank":4816,"name":"Lmf1","annotation":"Lipase maturation factor 1; Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway. Each LMF1 molecule chaperones 50 or more molecules of LPL."},{"id":"ENSMUSP00000056703","abundance":7.16,"rank":4817,"name":"Ly6e","annotation":"Lymphocyte antigen 6E; Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response."},{"id":"ENSMUSP00000018184","abundance":7.16,"rank":4818,"name":"Rrp7a","annotation":"Ribosomal RNA-processing protein 7 homolog A; Belongs to the RRP7 family."},{"id":"ENSMUSP00000022311","abundance":7.16,"rank":4819,"name":"Oxsm","annotation":"3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial; May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function."},{"id":"ENSMUSP00000105776","abundance":7.15,"rank":4820,"name":"BB287469","annotation":"Expressed sequence BB287469; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000132993","abundance":7.15,"rank":4821,"name":"Gm4027","annotation":"Predicted gene 4027."},{"id":"ENSMUSP00000136486","abundance":7.15,"rank":4822,"name":"Gm2075","annotation":"Predicted gene 2075; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000052128","abundance":7.15,"rank":4823,"name":"Lor","annotation":"Loricrin; Major keratinocyte cell envelope protein."},{"id":"ENSMUSP00000058548","abundance":7.15,"rank":4824,"name":"Cryga","annotation":"Gamma-crystallin A; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000033898","abundance":7.15,"rank":4825,"name":"Col4a1","annotation":"Collagen alpha-1(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen."},{"id":"ENSMUSP00000055036","abundance":7.15,"rank":4826,"name":"Lsm14b","annotation":"Protein LSM14 homolog B; May play a role in control of mRNA translation. Belongs to the LSM14 family."},{"id":"ENSMUSP00000110663","abundance":7.15,"rank":4827,"name":"Lman2l","annotation":"VIP36-like protein; May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53 (By similarity)."},{"id":"ENSMUSP00000032114","abundance":7.15,"rank":4828,"name":"Mogs","annotation":"Mannosyl-oligosaccharide glucosidase; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor; Belongs to the glycosyl hydrolase 63 family."},{"id":"ENSMUSP00000021734","abundance":7.15,"rank":4829,"name":"Gng4","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000021610","abundance":7.14,"rank":4830,"name":"Chga","annotation":"p-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. Pyroglutaminated (pGlu)-serpinin exerts an antiapoptotic effect on cells exposed to oxidative stress."},{"id":"ENSMUSP00000037783","abundance":7.14,"rank":4831,"name":"Gadd45gip1","annotation":"Growth arrest and DNA damage-inducible proteins-interacting protein 1; Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis."},{"id":"ENSMUSP00000030013","abundance":7.14,"rank":4832,"name":"Xpa","annotation":"DNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation (By similarity); Belongs to the XPA family."},{"id":"ENSMUSP00000030894","abundance":7.13,"rank":4833,"name":"Lrrc47","annotation":"Leucine-rich repeat-containing protein 47."},{"id":"ENSMUSP00000033056","abundance":7.13,"rank":4834,"name":"Pycard","annotation":"Apoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis involving predominantly caspase-8 and also caspase-9 in a probable cell type-specific manner. Involved in activation of the mitochondrial apoptotic pathway, promotes caspase-8- dependent proteolytic maturation of BID independently of FADD in certain cell types and also mediates mitochondrial translocation of BAX and activates BAX-dependent apoptosis coupled to activation of caspase- 9, -2 and -3. Involved in macrophage pyroptosis, a cas [...] "},{"id":"ENSMUSP00000095970","abundance":7.13,"rank":4835,"name":"Mlycd","annotation":"Malonyl-CoA decarboxylase, mitochondrial; Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in mus [...] "},{"id":"ENSMUSP00000096241","abundance":7.12,"rank":4836,"name":"Prx","annotation":"Periaxin; Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier.  [...] "},{"id":"ENSMUSP00000028071","abundance":7.12,"rank":4837,"name":"Bmi1","annotation":"Polycomb complex protein BMI-1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A. In the PRC1-like complex, regulates the E3 ub [...] "},{"id":"ENSMUSP00000001544","abundance":7.11,"rank":4838,"name":"Vwa5a","annotation":"Von Willebrand factor A domain-containing protein 5A; May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis (By similarity)."},{"id":"ENSMUSP00000022836","abundance":7.1,"rank":4839,"name":"Mcpt1","annotation":"Mast cell protease 1; Has a chymotrypsin-like activity."},{"id":"ENSMUSP00000093962","abundance":7.1,"rank":4840,"name":"B3gat3","annotation":"Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Stimulates 2-phosphoxylose phosphatase  [...] "},{"id":"ENSMUSP00000104314","abundance":7.09,"rank":4841,"name":"Ntn1","annotation":"Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Involved in dorsal root ganglion axon projection towards the spinal cord. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by [...] "},{"id":"ENSMUSP00000084887","abundance":7.09,"rank":4842,"name":"Myo1f","annotation":"Unconventional myosin-If; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000129704","abundance":7.09,"rank":4843,"name":"Enoph1","annotation":"Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family."},{"id":"ENSMUSP00000035121","abundance":7.08,"rank":4844,"name":"Amotl2","annotation":"Angiomotin-like protein 2; Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity); Belongs to the angiomotin family."},{"id":"ENSMUSP00000136303","abundance":7.08,"rank":4845,"name":"ENSMUSP00000136303","annotation":"annotation not available"},{"id":"ENSMUSP00000049212","abundance":7.08,"rank":4846,"name":"Agr3","annotation":"Anterior gradient protein 3; Required for calcium-mediated regulation of ciliary beat frequency and mucociliary clearance in the airway. Might be involved in the regulation of intracellular calcium in tracheal epithelial cells."},{"id":"ENSMUSP00000104973","abundance":7.08,"rank":4847,"name":"Dbndd2","annotation":"Dysbindin domain-containing protein 2; May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro) (By similarity); Belongs to the dysbindin family."},{"id":"ENSMUSP00000053877","abundance":7.06,"rank":4848,"name":"Fam120a","annotation":"Constitutive coactivator of PPAR-gamma-like protein 1; Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3- kinase. Binds RNA and promotes the secretion of IGF-II (By similarity). May participate in mRNA transport in the cytoplasm."},{"id":"ENSMUSP00000100071","abundance":7.06,"rank":4849,"name":"Nudt10","annotation":"Diphosphoinositol polyphosphate phosphohydrolase 3-alpha; Cleaves a beta-phosphate from the diphosphate groups in PP- InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5- phosphoribose 1-diphosphate; however, the relevance of such activity in vivo remains unclear; Belongs to the Nudix hydrolase family. DIPP subfamily."},{"id":"ENSMUSP00000100072","abundance":7.06,"rank":4850,"name":"Nudt11","annotation":"Nudix (nucleoside diphosphate linked moiety X)-type motif 11."},{"id":"ENSMUSP00000135920","abundance":7.06,"rank":4851,"name":"Mlf2","annotation":"Myeloid leukemia factor 2."},{"id":"ENSMUSP00000110804","abundance":7.05,"rank":4852,"name":"Ubxn7","annotation":"UBX domain-containing protein 7; Ubiquitin-binding adapter that links a subset of NEDD8- associated cullin ring ligases (CRLs) to the segregase VCP/p97, to regulate turnover of their ubiquitination substrates (By similarity)."},{"id":"ENSMUSP00000150218","abundance":7.05,"rank":4853,"name":"Olfr855","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000099750","abundance":7.04,"rank":4854,"name":"Sp3","annotation":"Transcription factor Sp3; Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. Binds to GT and GC boxes promoter elements. Competes with SP1 for the GC-box promoters. Weak activator of transcription but can activate a number of genes involved in different processes such as cell-cycle regulation, hormone-induction and house-keeping (By similarity)."},{"id":"ENSMUSP00000027741","abundance":7.04,"rank":4855,"name":"Xpr1","annotation":"Xenotropic and polytropic retrovirus receptor 1; Plays a role in phosphate homeostasis. Mediates phosphate export from the cell. Binds inositol hexakisphosphate (Ins6P) and similar inositol polyphosphates, such as 5-diphospho-inositol pentakisphosphate (5-InsP7); these are important intracellular signaling molecules (By similarity). Potential receptor for xenotropic and polytropic murine leukemia retroviruses ; Belongs to the SYG1 (TC 2.A.94) family."},{"id":"ENSMUSP00000031399","abundance":7.04,"rank":4856,"name":"Psph","annotation":"Phosphoserine phosphatase; Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity); Belongs to the HAD-like hydrolase superfamily. SerB family."},{"id":"ENSMUSP00000023867","abundance":7.03,"rank":4857,"name":"Rfc2","annotation":"Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity)."},{"id":"ENSMUSP00000078245","abundance":7.03,"rank":4858,"name":"Numbl","annotation":"Numb-like protein; Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B ac [...] "},{"id":"ENSMUSP00000023237","abundance":7.03,"rank":4859,"name":"Naprt","annotation":"Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis; Belongs to the NAPRTase family."},{"id":"ENSMUSP00000101331","abundance":7.03,"rank":4860,"name":"Fbxo6","annotation":"F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolde [...] "},{"id":"ENSMUSP00000027286","abundance":7.03,"rank":4861,"name":"Coa5","annotation":"Cytochrome c oxidase assembly factor 5; Involved in an early step of the mitochondrial complex IV assembly process."},{"id":"ENSMUSP00000032288","abundance":7.02,"rank":4862,"name":"Klra1","annotation":"T-cell surface glycoprotein YE1/48; Receptor on natural killer (NK) cells for H-2d alleles. Inhibits the activity of NK cells thus preventing cell lysis."},{"id":"ENSMUSP00000056099","abundance":7.02,"rank":4863,"name":"Abhd17b","annotation":"Alpha/beta hydrolase domain-containing protein 17B; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Has depalmitoylating activity towards GAP43. Has depalmitoylating activity towards MAP6. Has depalmitoylating activity towards NRAS (By similarity)."},{"id":"ENSMUSP00000050389","abundance":7.01,"rank":4864,"name":"Prss32","annotation":"Protease, serine 32; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000027592","abundance":7.01,"rank":4865,"name":"Ubxn4","annotation":"UBX domain-containing protein 4; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD."},{"id":"ENSMUSP00000035325","abundance":7.01,"rank":4866,"name":"Ndufaf5","annotation":"Arginine-hydroxylase NDUFAF5, mitochondrial; Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT- ND1) at early stages. Acts by mediating hydroxylation of 'Arg-111' of NDUFS7. May also have methyltransferase activity."},{"id":"ENSMUSP00000140744","abundance":7,"rank":4867,"name":"Terf1","annotation":"Telomeric repeat-binding factor 1; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways."},{"id":"ENSMUSP00000148077","abundance":7,"rank":4868,"name":"Isyna1","annotation":"Inositol-3-phosphate synthase 1; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). Belongs to the myo-inositol 1-phosphate synthase family."},{"id":"ENSMUSP00000083901","abundance":7,"rank":4869,"name":"Serpinb3b","annotation":"Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3B; Belongs to the serpin family."},{"id":"ENSMUSP00000101718","abundance":7,"rank":4870,"name":"Bnip3","annotation":"BCL2/adenovirus E1B 19 kDa protein-interacting protein 3; Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mito [...] "},{"id":"ENSMUSP00000084480","abundance":7,"rank":4871,"name":"Guf1","annotation":"Translation factor Guf1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily."},{"id":"ENSMUSP00000006254","abundance":7,"rank":4872,"name":"Tbcb","annotation":"Tubulin-folding cofactor B; Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (By similarity). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth ; Belongs to the TBCB family."},{"id":"ENSMUSP00000022722","abundance":7,"rank":4873,"name":"Acod1","annotation":"Cis-aconitate decarboxylase; Involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages. Plays a role in the embryo implantation."},{"id":"ENSMUSP00000060457","abundance":6.99,"rank":4874,"name":"Car5a","annotation":"Carbonic anhydrase 5A, mitochondrial; Reversible hydration of carbon dioxide. Low activity."},{"id":"ENSMUSP00000023630","abundance":6.99,"rank":4875,"name":"Psmg1","annotation":"Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity)."},{"id":"ENSMUSP00000096769","abundance":6.99,"rank":4876,"name":"Ddx4","annotation":"ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle. Requir [...] "},{"id":"ENSMUSP00000102554","abundance":6.98,"rank":4877,"name":"Tlk2","annotation":"Serine/threonine-protein kinase tousled-like 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (By similarity). Negative regulator of amino acid starvation-induced autophagy (By similarity)."},{"id":"ENSMUSP00000115865","abundance":6.98,"rank":4878,"name":"Fam241b","annotation":"Protein FAM241B; May play a role in lysosome homeostasis. Belongs to the FAM241 family."},{"id":"ENSMUSP00000029208","abundance":6.98,"rank":4879,"name":"Slc13a3","annotation":"Solute carrier family 13 member 3; High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, including succinate, alpha-ketoglutarate and N-acetylaspartate. The stoichiometry is probably 3 Na(+) for 1 divalent succinate."},{"id":"ENSMUSP00000030486","abundance":6.97,"rank":4880,"name":"Cyp4a31","annotation":"Cytochrome P450, family 4, subfamily a, polypeptide 31; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000061624","abundance":6.97,"rank":4881,"name":"Rabgap1","annotation":"Rab GTPase-activating protein 1; May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition (By similarity)."},{"id":"ENSMUSP00000129635","abundance":6.97,"rank":4882,"name":"Tdrkh","annotation":"Tudor and KH domain-containing protein; Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature [...] "},{"id":"ENSMUSP00000021939","abundance":6.97,"rank":4883,"name":"Cdk20","annotation":"Cyclin-dependent kinase 20; Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160' (By similarity). Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."},{"id":"ENSMUSP00000109271","abundance":6.96,"rank":4884,"name":"Kat5","annotation":"Histone acetyltransferase KAT5; Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (By similarity). This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (By similarity). This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor me [...] "},{"id":"ENSMUSP00000104895","abundance":6.96,"rank":4885,"name":"Mier3","annotation":"Mesoderm induction early response protein 3; Transcriptional repressor."},{"id":"ENSMUSP00000075614","abundance":6.96,"rank":4886,"name":"Upf3b","annotation":"UPF3 regulator of nonsense transcripts homolog B (yeast)."},{"id":"ENSMUSP00000085316","abundance":6.96,"rank":4887,"name":"Adnp","annotation":"Activity-dependent neuroprotector homeobox protein; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation."},{"id":"ENSMUSP00000075802","abundance":6.96,"rank":4888,"name":"Gm11937","annotation":"Predicted gene 11937."},{"id":"ENSMUSP00000072150","abundance":6.96,"rank":4889,"name":"Gm11938","annotation":"Keratin-associated protein 2-4."},{"id":"ENSMUSP00000074461","abundance":6.96,"rank":4890,"name":"Krtap2-4","annotation":"Keratin associated protein 2-4."},{"id":"ENSMUSP00000023351","abundance":6.96,"rank":4891,"name":"Mzt2","annotation":"Mitotic-spindle organizing protein 2; Belongs to the MOZART2 family."},{"id":"ENSMUSP00000140536","abundance":6.96,"rank":4892,"name":"Erbin","annotation":"Erbin; Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated ERBB2 'Tyr-1248' receptor, it may contribute to stabilize this unphosphorylated state (By similarity). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion."},{"id":"ENSMUSP00000048802","abundance":6.94,"rank":4893,"name":"Ddx52","annotation":"Probable ATP-dependent RNA helicase DDX52; Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily."},{"id":"ENSMUSP00000085683","abundance":6.94,"rank":4894,"name":"Mapk8ip3","annotation":"C-Jun-amino-terminal kinase-interacting protein 3; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Promotes neuronal axon elongation in a kinesin- and JNK-dependent manner. Activates cofilin at axon tips via local activation of JNK, thereby regulating filopodial dynamics and enhancing axon elongation. Its binding to kin [...] "},{"id":"ENSMUSP00000036710","abundance":6.94,"rank":4895,"name":"Lars2","annotation":"Probable leucine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000004686","abundance":6.94,"rank":4896,"name":"Pex11g","annotation":"Peroxisomal membrane protein 11C; Promotes membrane protrusion and elongation on the peroxisomal surface."},{"id":"ENSMUSP00000098890","abundance":6.93,"rank":4897,"name":"Cited1","annotation":"Cbp/p300-interacting transactivator 1; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional c [...] "},{"id":"ENSMUSP00000045357","abundance":6.92,"rank":4898,"name":"Limd2","annotation":"LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility."},{"id":"ENSMUSP00000045864","abundance":6.92,"rank":4899,"name":"Nceh1","annotation":"Neutral cholesterol ester hydrolase 1; Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for cholesterol ester hydrolysis in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds."},{"id":"ENSMUSP00000060405","abundance":6.92,"rank":4900,"name":"Ucn2","annotation":"Urocortin-2; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family."},{"id":"ENSMUSP00000087079","abundance":6.91,"rank":4901,"name":"Dok1","annotation":"Docking protein 1; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity)."},{"id":"ENSMUSP00000145120","abundance":6.91,"rank":4902,"name":"Myadm","annotation":"Myeloid-associated differentiation marker."},{"id":"ENSMUSP00000100959","abundance":6.9,"rank":4903,"name":"Smim24","annotation":"Small integral membrane protein 24."},{"id":"ENSMUSP00000022147","abundance":6.9,"rank":4904,"name":"Smn1","annotation":"Survival motor neuron protein; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the ch [...] "},{"id":"ENSMUSP00000040430","abundance":6.9,"rank":4905,"name":"Camkv","annotation":"CaM kinase-like vesicle-associated protein; Does not appear to have detectable kinase activity."},{"id":"ENSMUSP00000023105","abundance":6.9,"rank":4906,"name":"Endou","annotation":"Poly(U)-specific endoribonuclease; Endoribonuclease that cleaves single-stranded RNAs at uridylates and releases products that have 2'-3'-cyclic phosphate termini; Belongs to the ENDOU family."},{"id":"ENSMUSP00000081285","abundance":6.9,"rank":4907,"name":"Txlna","annotation":"Alpha-taxilin; May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells."},{"id":"ENSMUSP00000032124","abundance":6.89,"rank":4908,"name":"Mrpl19","annotation":"39S ribosomal protein L19, mitochondrial; Belongs to the bacterial ribosomal protein bL19 family."},{"id":"ENSMUSP00000036585","abundance":6.89,"rank":4909,"name":"Rxrb","annotation":"Retinoic acid receptor RXR-beta; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE); Belongs to the nuclear hormone receptor family. NR2 subfamily."},{"id":"ENSMUSP00000099501","abundance":6.88,"rank":4910,"name":"Ube4b","annotation":"Ubiquitin conjugation factor E4 B; Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase (By similarity). May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation (By similarity)."},{"id":"ENSMUSP00000034949","abundance":6.88,"rank":4911,"name":"Csnk1g1","annotation":"Casein kinase I isoform gamma-1; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CLSPN (By similarity). Regulates fast synaptic transmission mediated by glutamate."},{"id":"ENSMUSP00000107266","abundance":6.88,"rank":4912,"name":"Arntl2","annotation":"Aryl hydrocarbon receptor nuclear translocator-like protein 2; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...] "},{"id":"ENSMUSP00000015891","abundance":6.88,"rank":4913,"name":"Vps45","annotation":"Vacuolar protein sorting-associated protein 45; May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network."},{"id":"ENSMUSP00000056417","abundance":6.88,"rank":4914,"name":"Bod1","annotation":"Biorientation of chromosomes in cell division protein 1; Required for proper chromosome biorientation through the detection or correction of syntelic attachments in mitotic spindles. Belongs to the BOD1 family."},{"id":"ENSMUSP00000025906","abundance":6.87,"rank":4915,"name":"Esrra","annotation":"Steroid hormone receptor ERR1; Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium- chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle (By similarity); Belongs to the nuclear hormone receptor fam [...] "},{"id":"ENSMUSP00000104849","abundance":6.87,"rank":4916,"name":"Pelo","annotation":"Protein pelota homolog; Required for normal chromosome segregation during cell division and genomic stability. May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. May have ribonuclease activity (Potential)."},{"id":"ENSMUSP00000092690","abundance":6.87,"rank":4917,"name":"Lrrc8a","annotation":"Volume-regulated anion channel subunit LRRC8A; Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, [...] "},{"id":"ENSMUSP00000099307","abundance":6.86,"rank":4918,"name":"Slc38a10","annotation":"Putative sodium-coupled neutral amino acid transporter 10; Putative sodium-dependent amino acid/proton antiporter."},{"id":"ENSMUSP00000002677","abundance":6.84,"rank":4919,"name":"Axl","annotation":"Tyrosine-protein kinase receptor UFO; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates [...] "},{"id":"ENSMUSP00000031144","abundance":6.84,"rank":4920,"name":"Tmem165","annotation":"Transmembrane protein 165; May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation (By similarity)."},{"id":"ENSMUSP00000062011","abundance":6.84,"rank":4921,"name":"Svs3b","annotation":"Seminal vesicle secretory protein 3B."},{"id":"ENSMUSP00000028767","abundance":6.83,"rank":4922,"name":"Rtf1","annotation":"RNA polymerase-associated protein RTF1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription [...] "},{"id":"ENSMUSP00000026698","abundance":6.83,"rank":4923,"name":"Podxl","annotation":"Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin- dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial p [...] "},{"id":"ENSMUSP00000103058","abundance":6.83,"rank":4924,"name":"Zbtb7b","annotation":"Zinc finger and BTB domain-containing protein 7B; Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I mo [...] "},{"id":"ENSMUSP00000030984","abundance":6.83,"rank":4925,"name":"Rgs12","annotation":"Regulator of G-protein signaling 12; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form."},{"id":"ENSMUSP00000030303","abundance":6.83,"rank":4926,"name":"Cyp2j6","annotation":"Cytochrome P450 2J6."},{"id":"ENSMUSP00000045162","abundance":6.82,"rank":4927,"name":"Vasn","annotation":"Vasorin; May act as an inhibitor of TGF-beta signaling."},{"id":"ENSMUSP00000013130","abundance":6.81,"rank":4928,"name":"Strn3","annotation":"Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity); Belongs to the WD repeat striatin family."},{"id":"ENSMUSP00000095005","abundance":6.81,"rank":4929,"name":"Ermard","annotation":"ER membrane-associated RNA degradation."},{"id":"ENSMUSP00000027780","abundance":6.81,"rank":4930,"name":"Acbd3","annotation":"Golgi resident protein GCP60; Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (By similarity). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (By similarity)."},{"id":"ENSMUSP00000019833","abundance":6.81,"rank":4931,"name":"Fmc1","annotation":"Protein FMC1 homolog; Plays a role in the assembly/stability of the mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V)."},{"id":"ENSMUSP00000098710","abundance":6.8,"rank":4932,"name":"Iqsec1","annotation":"IQ motif and SEC7 domain-containing protein 1; Guanine nucleotide exchange factor for ARF1 and ARF6. Guanine nucleotide exchange factor activity is enhanced by lipid binding. Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin."},{"id":"ENSMUSP00000025381","abundance":6.8,"rank":4933,"name":"Spink1","annotation":"Serine protease inhibitor Kazal-type 1; Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens."},{"id":"ENSMUSP00000004430","abundance":6.8,"rank":4934,"name":"Clcn3","annotation":"H(+)/Cl(-) exchange transporter 3; Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. Belongs to the chloride channel (TC 2.A.49) family. ClC- 3/CLCN3 subfamily."},{"id":"ENSMUSP00000075235","abundance":6.8,"rank":4935,"name":"A1cf","annotation":"APOBEC1 complementation factor; Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also seems to protect the edited APOB mRNA from nonsense-mediated decay (By similarity)."},{"id":"ENSMUSP00000021634","abundance":6.79,"rank":4936,"name":"Akr1c13","annotation":"Aldo-keto reductase family 1 member C13; Catalyzes the dehydrogenation of 17-beta-hydroxysteroids. May also exhibit significant activity with a variety of cyclic and alicyclic alcohols. Uses both NAD and NADP, but the activity is much greater with NAD than with NADP (By similarity)."},{"id":"ENSMUSP00000094321","abundance":6.79,"rank":4937,"name":"Gm94","annotation":"Uncharacterized protein C5orf46 homolog."},{"id":"ENSMUSP00000019917","abundance":6.79,"rank":4938,"name":"Rwdd1","annotation":"RWD domain-containing protein 1; Protects DRG2 from proteolytic degradation. Belongs to the RWDD1/GIR2 family."},{"id":"ENSMUSP00000027667","abundance":6.79,"rank":4939,"name":"Pkp1","annotation":"Plakophilin-1; Seems to play a role in junctional plaques; Belongs to the beta-catenin family."},{"id":"ENSMUSP00000116006","abundance":6.79,"rank":4940,"name":"Satb1","annotation":"DNA-binding protein SATB1; Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis (By similarity). Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of [...] "},{"id":"ENSMUSP00000022089","abundance":6.79,"rank":4941,"name":"Med10","annotation":"Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000039298","abundance":6.78,"rank":4942,"name":"Eif4ebp3","annotation":"Eukaryotic translation initiation factor 4E-binding protein 3; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation."},{"id":"ENSMUSP00000021806","abundance":6.78,"rank":4943,"name":"Tpmt","annotation":"Thiopurine S-methyltransferase; Catalyzes the S-methylation of thiopurine drugs such as 6- mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family."},{"id":"ENSMUSP00000066280","abundance":6.78,"rank":4944,"name":"Scrt2","annotation":"Transcriptional repressor scratch 2; May be involved in transcriptional regulation; Belongs to the snail C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000046325","abundance":6.77,"rank":4945,"name":"Lce3b","annotation":"Late cornified envelope 3B."},{"id":"ENSMUSP00000006838","abundance":6.76,"rank":4946,"name":"Qars","annotation":"Glutamine--tRNA ligase; Glutamine--tRNA ligase. Plays a critical role in brain development; Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000034745","abundance":6.76,"rank":4947,"name":"Myo1e","annotation":"Unconventional myosin-Ie; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain (By similarity). Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles alon [...] "},{"id":"ENSMUSP00000047586","abundance":6.75,"rank":4948,"name":"Gngt2","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000136952","abundance":6.75,"rank":4949,"name":"Bex3","annotation":"Protein BEX3; May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death; Belongs to the BEX family."},{"id":"ENSMUSP00000107063","abundance":6.74,"rank":4950,"name":"Slc39a13","annotation":"Zinc transporter ZIP13; Acts as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family."},{"id":"ENSMUSP00000055437","abundance":6.74,"rank":4951,"name":"Neurl3","annotation":"E3 ubiquitin-protein ligase NEURL3; E3 ubiquitin-protein ligase. Seems to utilize UBE2E1. In vitro, generates polyubiquitin chains via non-canonical lysine residues suggesting that it is not involved in tagging substrates for proteasomal degradation."},{"id":"ENSMUSP00000023064","abundance":6.73,"rank":4952,"name":"Cby1","annotation":"Protein chibby homolog 1; Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta- catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation. Belongs to the chibby family."},{"id":"ENSMUSP00000104056","abundance":6.73,"rank":4953,"name":"Pou2f2","annotation":"POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform OCT2.5 activates the U2 small nuclear RNA (snRNA) promoter. Isoforms OCT2.1, OCT2.2 and OCT2.3 activate octamer-containing promoters. Isoforms OCT2.4 and OCT2.5 repress some promoters and activate others. Isoform OCT2.7 is unable to bind to the octamer motif, but can still activate the b [...] "},{"id":"ENSMUSP00000071748","abundance":6.73,"rank":4954,"name":"Fmr1nb","annotation":"Fragile X mental retardation 1 neighbor protein."},{"id":"ENSMUSP00000014421","abundance":6.72,"rank":4955,"name":"Ankrd17","annotation":"Ankyrin repeat domain-containing protein 17; Could play pivotal roles in cell cycle and DNA regulation. Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways. Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too. Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system."},{"id":"ENSMUSP00000098035","abundance":6.72,"rank":4956,"name":"Trrap","annotation":"Transformation/transcription domain-associated protein; Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4- mediated transcription activation. Probably acts by linking transcrip [...] "},{"id":"ENSMUSP00000030265","abundance":6.72,"rank":4957,"name":"Dph2","annotation":"2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2)."},{"id":"ENSMUSP00000029480","abundance":6.72,"rank":4958,"name":"Prpf38b","annotation":"Pre-mRNA-splicing factor 38B; May be required for pre-mRNA splicing; Belongs to the PRP38 family."},{"id":"ENSMUSP00000006669","abundance":6.72,"rank":4959,"name":"Pdk1","annotation":"[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial; Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protect [...] "},{"id":"ENSMUSP00000030003","abundance":6.71,"rank":4960,"name":"Exosc3","annotation":"Exosome complex component RRP40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] "},{"id":"ENSMUSP00000054177","abundance":6.71,"rank":4961,"name":"Pnma3","annotation":"Paraneoplastic antigen Ma3 homolog; Belongs to the PNMA family."},{"id":"ENSMUSP00000035930","abundance":6.71,"rank":4962,"name":"Nol10","annotation":"Nucleolar protein 10."},{"id":"ENSMUSP00000030286","abundance":6.71,"rank":4963,"name":"Dock7","annotation":"Dedicator of cytokinesis protein 7; Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization (By similarity). As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton (By similarity). Has a role in pigmentation. Involved in the regulation of cortical neurogenesis through the control of rad [...] "},{"id":"ENSMUSP00000052226","abundance":6.71,"rank":4964,"name":"Gk2","annotation":"Glycerol kinase 2; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family."},{"id":"ENSMUSP00000105584","abundance":6.7,"rank":4965,"name":"Serpina3i","annotation":"Serine (or cysteine) peptidase inhibitor, clade A, member 3I; Belongs to the serpin family."},{"id":"ENSMUSP00000065743","abundance":6.7,"rank":4966,"name":"Cept1","annotation":"Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity (By similarity); Belongs to the CDP-alcohol phosphatidyltransferase class-I family."},{"id":"ENSMUSP00000107657","abundance":6.7,"rank":4967,"name":"Lhx9","annotation":"LIM/homeobox protein Lhx9; Involved in gonadal development."},{"id":"ENSMUSP00000016168","abundance":6.7,"rank":4968,"name":"Lbp","annotation":"Lipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide."},{"id":"ENSMUSP00000125491","abundance":6.7,"rank":4969,"name":"Txndc9","annotation":"Thioredoxin domain-containing protein 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin."},{"id":"ENSMUSP00000048826","abundance":6.7,"rank":4970,"name":"Mmaa","annotation":"Methylmalonic aciduria type A homolog, mitochondrial; GTPase, binds and hydrolyzes GTP. Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis. Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) and reactivation of the enzyme during catalysis. Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily."},{"id":"ENSMUSP00000058483","abundance":6.7,"rank":4971,"name":"BC048671","annotation":"Uncharacterized protein C3orf22 homolog."},{"id":"ENSMUSP00000054944","abundance":6.7,"rank":4972,"name":"Itgb6","annotation":"Integrin beta-6; Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R- G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation."},{"id":"ENSMUSP00000030834","abundance":6.7,"rank":4973,"name":"Nos3","annotation":"Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. May play a significant role in normal and abnormal limb development; Belongs to the NOS family."},{"id":"ENSMUSP00000105446","abundance":6.68,"rank":4974,"name":"Cox4i2","annotation":"Cytochrome c oxidase subunit 4 isoform 2, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives tran [...] "},{"id":"ENSMUSP00000001974","abundance":6.68,"rank":4975,"name":"Trmt1","annotation":"tRNA (guanine(26)-N(2))-dimethyltransferase; Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family."},{"id":"ENSMUSP00000037109","abundance":6.68,"rank":4976,"name":"Lzts3","annotation":"Leucine zipper putative tumor suppressor 3; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses; Belongs to the LZTS3 family."},{"id":"ENSMUSP00000029574","abundance":6.68,"rank":4977,"name":"Vcam1","annotation":"Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation."},{"id":"ENSMUSP00000047776","abundance":6.67,"rank":4978,"name":"Plpp6","annotation":"Phospholipid phosphatase 6; Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid (By similarity). Belongs to the PA-phosphatase related phosphoesterase family."},{"id":"ENSMUSP00000123270","abundance":6.67,"rank":4979,"name":"Ankhd1","annotation":"Ankyrin repeat and KH domain-containing 1."},{"id":"ENSMUSP00000047797","abundance":6.67,"rank":4980,"name":"Cpsf2","annotation":"Cleavage and polyadenylation specificity factor subunit 2; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing (By similarity)."},{"id":"ENSMUSP00000001672","abundance":6.66,"rank":4981,"name":"Ifrd1","annotation":"Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal."},{"id":"ENSMUSP00000141003","abundance":6.66,"rank":4982,"name":"Rbbp5","annotation":"Retinoblastoma-binding protein 5; As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self- renewal. In association with ASH2L and WDR5, stimulates the histone methyltransfe [...] "},{"id":"ENSMUSP00000038091","abundance":6.66,"rank":4983,"name":"Klc3","annotation":"Kinesin light chain 3; Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport."},{"id":"ENSMUSP00000106004","abundance":6.66,"rank":4984,"name":"Stard7","annotation":"StAR-related lipid transfer protein 7, mitochondrial; May play a protective role in mucosal tissues by preventing exaggerated allergic responses."},{"id":"ENSMUSP00000028342","abundance":6.65,"rank":4985,"name":"Ssna1","annotation":"Sjoegren syndrome nuclear autoantigen 1 homolog."},{"id":"ENSMUSP00000058205","abundance":6.64,"rank":4986,"name":"Hmx2","annotation":"Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development."},{"id":"ENSMUSP00000154361","abundance":6.64,"rank":4987,"name":"Ebag9","annotation":"Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases."},{"id":"ENSMUSP00000031840","abundance":6.64,"rank":4988,"name":"Gpnmb","annotation":"Transmembrane glycoprotein NMB; Could be a melanogenic enzyme; Belongs to the PMEL/NMB family."},{"id":"ENSMUSP00000021466","abundance":6.63,"rank":4989,"name":"Atl1","annotation":"Atlastin-1; GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development."},{"id":"ENSMUSP00000046532","abundance":6.63,"rank":4990,"name":"Grap2","annotation":"GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc; Belongs to the GRB2/sem-5/DRK family."},{"id":"ENSMUSP00000110528","abundance":6.63,"rank":4991,"name":"Parp9","annotation":"Protein mono-ADP-ribosyltransferase PARP9; ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (By similarity). In addition, positively regulates DTXL3 protein levels (By similarity). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to sub [...] "},{"id":"ENSMUSP00000131297","abundance":6.63,"rank":4992,"name":"H2-M2","annotation":"Histocompatibility 2, M region locus 2; Belongs to the MHC class I family."},{"id":"ENSMUSP00000022954","abundance":6.62,"rank":4993,"name":"Khdrbs3","annotation":"KH domain-containing, RNA-binding, signal transduction-associated protein 3; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides (By similarity). Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in splice site selection of vascular endothelial growth factor (By similarity). In vitro regulates CD44 [...] "},{"id":"ENSMUSP00000078998","abundance":6.62,"rank":4994,"name":"Aifm2","annotation":"Ferroptosis suppressor protein 1; A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical- trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels (By similarity). May play a role in mitochondrial oxidative signaling. Upon oxidative stress, associates with the lipid per [...] "},{"id":"ENSMUSP00000020964","abundance":6.62,"rank":4995,"name":"Fkbp1b","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the FKBP-type PPIase family. FKBP1 subfamily."},{"id":"ENSMUSP00000045634","abundance":6.61,"rank":4996,"name":"Antxr1","annotation":"Anthrax toxin receptor 1; Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells (By similarity)."},{"id":"ENSMUSP00000008051","abundance":6.61,"rank":4997,"name":"Cabs1","annotation":"Calcium-binding and spermatid-specific protein 1."},{"id":"ENSMUSP00000022766","abundance":6.61,"rank":4998,"name":"Tox4","annotation":"TOX high mobility group box family member 4; Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase."},{"id":"ENSMUSP00000140566","abundance":6.61,"rank":4999,"name":"Dnajb2","annotation":"DnaJ homolog subfamily B member 2; Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER- associated protein de [...] "},{"id":"ENSMUSP00000066015","abundance":6.61,"rank":5000,"name":"Lrrc8c","annotation":"Volume-regulated anion channel subunit LRRC8C; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRR [...] "},{"id":"ENSMUSP00000100774","abundance":6.61,"rank":5001,"name":"Ifna7","annotation":"Interferon alpha-7."},{"id":"ENSMUSP00000075018","abundance":6.61,"rank":5002,"name":"Tnfrsf22","annotation":"Tumor necrosis factor receptor superfamily member 22; Receptor for the cytotoxic ligand TNFSF10/TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. Protects cells against TRAIL mediated apoptosis possibly through ligand competition. Cannot induce the NF-kappa-B pathway."},{"id":"ENSMUSP00000004208","abundance":6.61,"rank":5003,"name":"Angptl2","annotation":"Angiopoietin-related protein 2; Induces sprouting in endothelial cells through an autocrine and paracrine action."},{"id":"ENSMUSP00000021837","abundance":6.61,"rank":5004,"name":"Serpinb9c","annotation":"Serine (or cysteine) peptidase inhibitor, clade B, member 9c; Belongs to the serpin family."},{"id":"ENSMUSP00000151537","abundance":6.61,"rank":5005,"name":"Gm49358","annotation":"Predicted gene, 49358."},{"id":"ENSMUSP00000032912","abundance":6.6,"rank":5006,"name":"Qprt","annotation":"Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family."},{"id":"ENSMUSP00000152430","abundance":6.6,"rank":5007,"name":"Dmac2l","annotation":"ATP synthase subunit s, mitochondrial; Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway."},{"id":"ENSMUSP00000113759","abundance":6.6,"rank":5008,"name":"Stmn4","annotation":"Stathmin-4; Exhibits microtubule-destabilizing activity; Belongs to the stathmin family."},{"id":"ENSMUSP00000126608","abundance":6.6,"rank":5009,"name":"R3hdm2","annotation":"R3H domain-containing protein 2."},{"id":"ENSMUSP00000085549","abundance":6.59,"rank":5010,"name":"Tbl1x","annotation":"F-box-like/WD repeat-containing protein TBL1X; F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity); Belongs to the WD repeat EBI family."},{"id":"ENSMUSP00000159164","abundance":6.59,"rank":5011,"name":"Ptpmt1","annotation":"Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a  [...] "},{"id":"ENSMUSP00000052095","abundance":6.59,"rank":5012,"name":"Col26a1","annotation":"Collagen alpha-1(XXVI) chain."},{"id":"ENSMUSP00000051838","abundance":6.58,"rank":5013,"name":"Pptc7","annotation":"Protein phosphatase PTC7 homolog; Protein phosphatase which positively regulates biosynthesis of the ubiquinone, coenzyme Q (By similarity). Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (By similarity); Belongs to the PP2C family."},{"id":"ENSMUSP00000032157","abundance":6.58,"rank":5014,"name":"Gxylt2","annotation":"Glucoside xylosyltransferase 2; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose."},{"id":"ENSMUSP00000120807","abundance":6.57,"rank":5015,"name":"Zcchc17","annotation":"Nucleolar protein of 40 kDa."},{"id":"ENSMUSP00000034021","abundance":6.57,"rank":5016,"name":"Galnt7","annotation":"N-acetylgalactosaminyltransferase 7; Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D- galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide s [...] "},{"id":"ENSMUSP00000027725","abundance":6.57,"rank":5017,"name":"Klhl12","annotation":"Kelch-like protein 12; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts w [...] "},{"id":"ENSMUSP00000099748","abundance":6.57,"rank":5018,"name":"Dmap1","annotation":"DNA methyltransferase 1-associated protein 1; Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucle [...] "},{"id":"ENSMUSP00000110955","abundance":6.57,"rank":5019,"name":"Kcnq5","annotation":"Potassium voltage-gated channel subfamily KQT member 5; Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. Therefore, it is important in the regulation of neuronal excitability. May contribute, with other potassium channels, to the molecular diversity of a heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current."},{"id":"ENSMUSP00000152940","abundance":6.57,"rank":5020,"name":"Lysmd3","annotation":"LysM and putative peptidoglycan-binding domain-containing protein 3; Essential for Golgi structural integrity."},{"id":"ENSMUSP00000084252","abundance":6.57,"rank":5021,"name":"Polr1c","annotation":"DNA-directed RNA polymerases I and III subunit RPAC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)."},{"id":"ENSMUSP00000076686","abundance":6.56,"rank":5022,"name":"Stk19","annotation":"Serine/threonine-protein kinase 19; Serine/threonine-protein kinase that acts as a key regulator of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89', thereby enhancing NRAS-binding to its downstream effectors. Belongs to the STK19 family."},{"id":"ENSMUSP00000052452","abundance":6.56,"rank":5023,"name":"Thnsl1","annotation":"Threonine synthase-like 1."},{"id":"ENSMUSP00000130666","abundance":6.55,"rank":5024,"name":"Mars","annotation":"Methionine--tRNA ligase, cytoplasmic; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus; Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000028966","abundance":6.54,"rank":5025,"name":"Defb22","annotation":"Beta-defensin 22; Probable component of sperm glycocalyx. Likely protects and facilitates transport of sperm in the female reproductive tract. Probably released from the sperm surface during capacitation. Belongs to the beta-defensin family."},{"id":"ENSMUSP00000112860","abundance":6.54,"rank":5026,"name":"Lsg1","annotation":"Large subunit GTPase 1 homolog; GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (By similarity); Belongs to the TRAFAC class YlqF/YawG GTPase family. LSG1 subfamily."},{"id":"ENSMUSP00000124131","abundance":6.54,"rank":5027,"name":"Tle3","annotation":"Transducin-like enhancer protein 3; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full- length TLE family members may be modulated by association with dominant-negative AES (By similarity). May play an important role during spermatogenesis."},{"id":"ENSMUSP00000001836","abundance":6.53,"rank":5028,"name":"Pwp1","annotation":"Periodic tryptophan protein 1 homolog; Chromatin-associated factor that regulates transcription (By similarity). Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (By similarity). Regulates the epigenetic status of rDNA (By similarity)."},{"id":"ENSMUSP00000022345","abundance":6.53,"rank":5029,"name":"Dnajc9","annotation":"DnaJ homolog subfamily C member 9; May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8."},{"id":"ENSMUSP00000006614","abundance":6.53,"rank":5030,"name":"Epha2","annotation":"Ephrin type-A receptor 2; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin- A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DS [...] "},{"id":"ENSMUSP00000048001","abundance":6.53,"rank":5031,"name":"Coq5","annotation":"2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2)."},{"id":"ENSMUSP00000108311","abundance":6.52,"rank":5032,"name":"Gnl3l","annotation":"Guanine nucleotide-binding protein-like 3-like protein; Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal proces [...] "},{"id":"ENSMUSP00000023897","abundance":6.52,"rank":5033,"name":"Gzma","annotation":"Granzyme A; Abundant protease in the cytosolic granules of cytotoxic T- cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity)."},{"id":"ENSMUSP00000099331","abundance":6.52,"rank":5034,"name":"Tcea2","annotation":"Transcription elongation factor A protein 2; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus."},{"id":"ENSMUSP00000027247","abundance":6.51,"rank":5035,"name":"Pdcl3","annotation":"Phosducin-like protein 3; Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (By similarity). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (By similarity); Belongs to the phosducin family."},{"id":"ENSMUSP00000002989","abundance":6.51,"rank":5036,"name":"Arrdc2","annotation":"Arrestin domain-containing protein 2."},{"id":"ENSMUSP00000137044","abundance":6.51,"rank":5037,"name":"Elmod2","annotation":"ELMO domain-containing protein 2; Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family."},{"id":"ENSMUSP00000061760","abundance":6.5,"rank":5038,"name":"Gprc5c","annotation":"G-protein coupled receptor family C group 5 member C; This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G- protein signaling pathways."},{"id":"ENSMUSP00000116278","abundance":6.5,"rank":5039,"name":"2310061I04Rik","annotation":"RIKEN cDNA 2310061I04 gene."},{"id":"ENSMUSP00000037022","abundance":6.5,"rank":5040,"name":"Slco1a1","annotation":"Solute carrier organic anion transporter family member 1A1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, prostaglandin E2 (PGE2), dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate, sulfobromophthalein (BSP), ouabain and gadoxetate; Belongs to the organo anion transporter (TC 2.A.60) family."},{"id":"ENSMUSP00000028639","abundance":6.5,"rank":5041,"name":"Meis2","annotation":"Homeobox protein Meis2; Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probab [...] "},{"id":"ENSMUSP00000054085","abundance":6.5,"rank":5042,"name":"Defb9","annotation":"Beta-defensin 9; Has antibacterial activity."},{"id":"ENSMUSP00000067135","abundance":6.49,"rank":5043,"name":"Mrfap1","annotation":"MORF4 family-associated protein 1; Belongs to the MORF4 family-associated protein family."},{"id":"ENSMUSP00000002818","abundance":6.49,"rank":5044,"name":"Ykt6","annotation":"Synaptobrevin homolog YKT6; Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity; Belongs to the synaptobrevin family."},{"id":"ENSMUSP00000041294","abundance":6.49,"rank":5045,"name":"Sntb1","annotation":"Beta-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex; Belongs to the syntrophin family."},{"id":"ENSMUSP00000080791","abundance":6.49,"rank":5046,"name":"Ube2o","annotation":"(E3-independent) E2 ubiquitin-conjugating enzyme UBE2O; E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other [...] "},{"id":"ENSMUSP00000040232","abundance":6.48,"rank":5047,"name":"Wapl","annotation":"Wings apart-like protein homolog; Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair (By similarity); Belongs to the WAPL family."},{"id":"ENSMUSP00000117346","abundance":6.48,"rank":5048,"name":"Ap3m1","annotation":"AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals."},{"id":"ENSMUSP00000143128","abundance":6.48,"rank":5049,"name":"Lgi1","annotation":"Leucine-rich glioma-inactivated protein 1; Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity)."},{"id":"ENSMUSP00000078198","abundance":6.48,"rank":5050,"name":"Rph3a","annotation":"Rabphilin-3A; Plays an essential role in docking and fusion steps of regulated exocytosis (By similarity). At the presynaptic level, RPH3A is recruited by RAB3A to the synaptic vesicle membrane in a GTP- dependent manner where it modulates synaptic vesicle trafficking and calcium-triggered neurotransmitter release (By similarity). In the post-synaptic compartment, forms a ternary complex with GRIN2A and DLG4 and regulates NMDA receptor stability. Plays also a role in the exocytosis of arginine vasopressin hormone (By similarity)."},{"id":"ENSMUSP00000044687","abundance":6.47,"rank":5051,"name":"Trmt6","annotation":"tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries; Belongs to the TRM6/GCD10 family."},{"id":"ENSMUSP00000116494","abundance":6.47,"rank":5052,"name":"Mapkap1","annotation":"Target of rapamycin complex 2 subunit MAPKAP1; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the  [...] "},{"id":"ENSMUSP00000137123","abundance":6.47,"rank":5053,"name":"Ryr1","annotation":"Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for nor [...] "},{"id":"ENSMUSP00000042019","abundance":6.46,"rank":5054,"name":"Acot5","annotation":"Acyl-coenzyme A thioesterase 5; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Mainly active on medium-chain acyl-CoAs. Seems to be involved in intraperoxisomal regulation of acyl-CoA levels, but not CoASH levels. May have a function in termination of beta-oxidation of fatty acids."},{"id":"ENSMUSP00000034620","abundance":6.46,"rank":5055,"name":"Acrv1","annotation":"Acrosomal protein SP-10."},{"id":"ENSMUSP00000028584","abundance":6.46,"rank":5056,"name":"Commd9","annotation":"COMM domain-containing protein 9; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits."},{"id":"ENSMUSP00000063894","abundance":6.46,"rank":5057,"name":"Eif2d","annotation":"Eukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its  [...] "},{"id":"ENSMUSP00000080998","abundance":6.45,"rank":5058,"name":"mt-Nd3","annotation":"NADH-ubiquinone oxidoreductase chain 3; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)."},{"id":"ENSMUSP00000000058","abundance":6.45,"rank":5059,"name":"Cav2","annotation":"Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (B [...] "},{"id":"ENSMUSP00000029624","abundance":6.44,"rank":5060,"name":"Mcub","annotation":"Calcium uniporter regulatory subunit MCUb, mitochondrial; Negatively regulates the activity of MCU, the mitochondrial inner membrane calcium uniporter, and thereby modulates calcium uptake into the mitochondrion. Does not form functional calcium channels by itself. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways."},{"id":"ENSMUSP00000021085","abundance":6.44,"rank":5061,"name":"Nup85","annotation":"Nuclear pore complex protein Nup85; Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance. As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus. The Nup107-160 complex seems to be required for spindle assembly during mitosis. NUP85 is required for membrane clustering of CCL2-activated CCR2. Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade. Invo [...] "},{"id":"ENSMUSP00000035404","abundance":6.43,"rank":5062,"name":"Plvap","annotation":"Plasmalemma vesicle-associated protein; Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development."},{"id":"ENSMUSP00000001878","abundance":6.43,"rank":5063,"name":"Hoxd12","annotation":"Homeobox protein Hox-D12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis."},{"id":"ENSMUSP00000124931","abundance":6.41,"rank":5064,"name":"Impdh1","annotation":"Inosine-5'-monophosphate dehydrogenase 1; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors."},{"id":"ENSMUSP00000080866","abundance":6.41,"rank":5065,"name":"Mep1b","annotation":"Meprin A subunit beta; Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components (By similarity)."},{"id":"ENSMUSP00000045710","abundance":6.41,"rank":5066,"name":"Fgf1","annotation":"Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] "},{"id":"ENSMUSP00000104279","abundance":6.4,"rank":5067,"name":"Zbtb4","annotation":"Zinc finger and BTB domain-containing protein 4; Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. Plays a role in postnatal myogenesis, may be involved in [...] "},{"id":"ENSMUSP00000131648","abundance":6.4,"rank":5068,"name":"Gng13","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000049112","abundance":6.4,"rank":5069,"name":"Sltm","annotation":"SAFB-like transcription modulator; When overexpressed, acts as a general inhibitor of transcription that eventually leads to apoptosis."},{"id":"ENSMUSP00000090873","abundance":6.4,"rank":5070,"name":"Smco1","annotation":"Single-pass membrane and coiled-coil domain-containing protein 1."},{"id":"ENSMUSP00000062277","abundance":6.39,"rank":5071,"name":"Trim32","annotation":"E3 ubiquitin-protein ligase TRIM32; Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin). May ubiquitinate BBS2 (By similarity). Ubiquitinates PIAS4/PIASY and promotes its degradation in keratinocytes treated with UVB and TNF-alpha."},{"id":"ENSMUSP00000130245","abundance":6.39,"rank":5072,"name":"Fxyd3","annotation":"FXYD domain-containing ion transport regulator 3; Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (By similarity); Belongs to the FXYD family."},{"id":"ENSMUSP00000076887","abundance":6.39,"rank":5073,"name":"Lyzl4","annotation":"Lysozyme-like protein 4; May be involved in fertilization. Has no detectable bacteriolytic in vitro. Has no lysozyme activity in vitro (By similarity)."},{"id":"ENSMUSP00000108617","abundance":6.39,"rank":5074,"name":"Mid2","annotation":"Probable E3 ubiquitin-protein ligase MID2; May play a role in microtubule stabilization. Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000026011","abundance":6.39,"rank":5075,"name":"Sfxn2","annotation":"Sideroflexin-2; Mitochondrial amino-acid transporter that mediates transport of serine into mitochondria."},{"id":"ENSMUSP00000010807","abundance":6.39,"rank":5076,"name":"Fads1","annotation":"Acyl-CoA (8-3)-desaturase; Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n- 6) and eicosapentaenoate (E [...] "},{"id":"ENSMUSP00000017741","abundance":6.38,"rank":5077,"name":"Krt12","annotation":"Keratin, type I cytoskeletal 12; May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity."},{"id":"ENSMUSP00000047119","abundance":6.38,"rank":5078,"name":"Gnl3","annotation":"Guanine nucleotide-binding protein-like 3; May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation; Belongs to the TRAFAC class YlqF/YawG GTPase family."},{"id":"ENSMUSP00000159121","abundance":6.38,"rank":5079,"name":"Gla","annotation":"Alpha-galactosidase A."},{"id":"ENSMUSP00000021784","abundance":6.38,"rank":5080,"name":"Irf4","annotation":"Interferon regulatory factor 4; Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA- 3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 and [...] "},{"id":"ENSMUSP00000132443","abundance":6.37,"rank":5081,"name":"Mrps12","annotation":"28S ribosomal protein S12, mitochondrial; Belongs to the universal ribosomal protein uS12 family."},{"id":"ENSMUSP00000056377","abundance":6.37,"rank":5082,"name":"Pnlip","annotation":"Pancreatic triacylglycerol lipase; Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones (By similarity)."},{"id":"ENSMUSP00000093074","abundance":6.36,"rank":5083,"name":"Defa36","annotation":"Defensin, alpha, 36."},{"id":"ENSMUSP00000081053","abundance":6.36,"rank":5084,"name":"Defa37","annotation":"Defensin, alpha, 36."},{"id":"ENSMUSP00000032559","abundance":6.36,"rank":5085,"name":"Rtn2","annotation":"Reticulon-2."},{"id":"ENSMUSP00000081712","abundance":6.36,"rank":5086,"name":"Dnajb5","annotation":"DnaJ homolog subfamily B member 5."},{"id":"ENSMUSP00000033156","abundance":6.36,"rank":5087,"name":"Dctn5","annotation":"Dynactin subunit 5; Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily."},{"id":"ENSMUSP00000106500","abundance":6.36,"rank":5088,"name":"Mcf2l","annotation":"Guanine nucleotide exchange factor DBS; Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways. Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N- terminus (By similarity)."},{"id":"ENSMUSP00000064261","abundance":6.36,"rank":5089,"name":"Kif2c","annotation":"Kinesin-like protein KIF2C; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis. Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (By similarity). Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily."},{"id":"ENSMUSP00000096184","abundance":6.36,"rank":5090,"name":"E130208F15Rik","annotation":"RIKEN cDNA E130208F15 gene."},{"id":"ENSMUSP00000000759","abundance":6.35,"rank":5091,"name":"Chmp1a","annotation":"Charged multivesicular body protein 1a; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] "},{"id":"ENSMUSP00000075573","abundance":6.35,"rank":5092,"name":"Pum3","annotation":"Pumilio homolog 3; Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells."},{"id":"ENSMUSP00000028764","abundance":6.35,"rank":5093,"name":"Oxt","annotation":"Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin."},{"id":"ENSMUSP00000035829","abundance":6.34,"rank":5094,"name":"Akap12","annotation":"A-kinase anchor protein 12; Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC)."},{"id":"ENSMUSP00000026120","abundance":6.34,"rank":5095,"name":"Bhlhe22","annotation":"Class E basic helix-loop-helix protein 22; Inhibits DNA binding of TCF3/E47 homodimers and TCF3 (E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA (By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealiza [...] "},{"id":"ENSMUSP00000154390","abundance":6.34,"rank":5096,"name":"Dnajc15","annotation":"DnaJ homolog subfamily C member 15; Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9 (By similarity). Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP."},{"id":"ENSMUSP00000063416","abundance":6.33,"rank":5097,"name":"Acsm5","annotation":"Acyl-coenzyme A synthetase ACSM5, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism."},{"id":"ENSMUSP00000110208","abundance":6.32,"rank":5098,"name":"Zfp467","annotation":"Zinc finger protein 467; Transcription factor that promotes adipocyte differentiation and suppresses osteoblast differentiation in the bone marrow. Enhances the osteoclast-supporting ability of stromal cells. Binds with STAT3 the consensus sequence 5'-CTTCTGGGAAGA-3' of the acute phase response element (APRE). Transactivates several promoters including FOS, OSM and PPARG. Recruits a histone deacetylase complex. Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000099510","abundance":6.31,"rank":5099,"name":"Mtor","annotation":"Serine/threonine-protein kinase mTOR; Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis (By similarity). This includes phosph [...] "},{"id":"ENSMUSP00000003436","abundance":6.31,"rank":5100,"name":"Abhd17a","annotation":"Alpha/beta hydrolase domain-containing protein 17A; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS. Has depalmitoylating activity towards DLG4/PSD95. May have depalmitoylating activity towars MAP6."},{"id":"ENSMUSP00000031334","abundance":6.31,"rank":5101,"name":"Eif2b1","annotation":"Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family."},{"id":"ENSMUSP00000109312","abundance":6.31,"rank":5102,"name":"Myg1","annotation":"UPF0160 protein MYG1, mitochondrial."},{"id":"ENSMUSP00000076093","abundance":6.3,"rank":5103,"name":"Utrn","annotation":"Utrophin."},{"id":"ENSMUSP00000021370","abundance":6.3,"rank":5104,"name":"L2hgdh","annotation":"L-2-hydroxyglutarate dehydrogenase, mitochondrial."},{"id":"ENSMUSP00000093329","abundance":6.3,"rank":5105,"name":"Pkib","annotation":"cAMP-dependent protein kinase inhibitor beta; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains; Belongs to the PKI family."},{"id":"ENSMUSP00000148684","abundance":6.29,"rank":5106,"name":"Sntb2","annotation":"Beta-2-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN (By similarity); Belongs to the syntrophin family."},{"id":"ENSMUSP00000040431","abundance":6.29,"rank":5107,"name":"Stub1","annotation":"STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 de [...] "},{"id":"ENSMUSP00000118656","abundance":6.29,"rank":5108,"name":"Tdp1","annotation":"Tyrosyl-DNA phosphodiesterase 1; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the [...] "},{"id":"ENSMUSP00000023128","abundance":6.28,"rank":5109,"name":"Itga5","annotation":"Integrin alpha-5 heavy chain; Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD [...] "},{"id":"ENSMUSP00000091224","abundance":6.28,"rank":5110,"name":"C130026I21Rik","annotation":"RIKEN cDNA C130026I21 gene."},{"id":"ENSMUSP00000020947","abundance":6.28,"rank":5111,"name":"Rdh14","annotation":"Retinol dehydrogenase 14; Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol. Shows a very weak activity towards 13-cis-retinol. Has no activity towards steroids."},{"id":"ENSMUSP00000036257","abundance":6.27,"rank":5112,"name":"Abi3bp","annotation":"ABI gene family, member 3 (NESH)-binding protein."},{"id":"ENSMUSP00000075619","abundance":6.27,"rank":5113,"name":"Rabep1","annotation":"Rab GTPase-binding effector protein 1; Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium ; Belongs to the rabaptin family."},{"id":"ENSMUSP00000021706","abundance":6.27,"rank":5114,"name":"Traf3","annotation":"TNF receptor-associated factor 3; Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'- linked ubiquitination of [...] "},{"id":"ENSMUSP00000014597","abundance":6.26,"rank":5115,"name":"Blk","annotation":"Tyrosine-protein kinase Blk; Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis d [...] "},{"id":"ENSMUSP00000115062","abundance":6.26,"rank":5116,"name":"Dsp","annotation":"Desmoplakin; Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes; Belongs to the plakin or cytolinker family."},{"id":"ENSMUSP00000127114","abundance":6.26,"rank":5117,"name":"Uroc1","annotation":"Urocanate hydratase."},{"id":"ENSMUSP00000009120","abundance":6.26,"rank":5118,"name":"Gabpa","annotation":"GA-binding protein alpha chain; Transcription factor capable of interacting with purine rich repeats (GA repeats); Belongs to the ETS family."},{"id":"ENSMUSP00000087197","abundance":6.26,"rank":5119,"name":"Chrac1","annotation":"Chromatin accessibility complex protein 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1."},{"id":"ENSMUSP00000043332","abundance":6.25,"rank":5120,"name":"Map6d1","annotation":"MAP6 domain-containing protein 1; May have microtubule-stabilizing activity."},{"id":"ENSMUSP00000100712","abundance":6.25,"rank":5121,"name":"Dnajb7","annotation":"DnaJ homolog subfamily B member 7; Probably acts as a co-chaperone."},{"id":"ENSMUSP00000034808","abundance":6.24,"rank":5122,"name":"Nnmt","annotation":"Nicotinamide N-methyltransferase; Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family."},{"id":"ENSMUSP00000058785","abundance":6.24,"rank":5123,"name":"Rrp1","annotation":"Ribosomal RNA processing protein 1 homolog A; Plays a critical role in the generation of 28S rRNA."},{"id":"ENSMUSP00000143401","abundance":6.24,"rank":5124,"name":"Mef2c","annotation":"Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1 (By similarity). Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of e [...] "},{"id":"ENSMUSP00000072920","abundance":6.24,"rank":5125,"name":"Ppp1r14bl","annotation":"Protein phosphatase 1, regulatory inhibitor subunit 14B-like."},{"id":"ENSMUSP00000028650","abundance":6.23,"rank":5126,"name":"Pex16","annotation":"Peroxisomal membrane protein PEX16; Required for peroxisome membrane biogenesis. May play a role in early stages of peroxisome assembly. Can recruit other peroxisomal proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from the endoplasmic reticulum (ER). May function as receptor for PEX3 (By similarity)."},{"id":"ENSMUSP00000009831","abundance":6.23,"rank":5127,"name":"Fxyd5","annotation":"FXYD domain-containing ion transport regulator 5; Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity)."},{"id":"ENSMUSP00000030365","abundance":6.22,"rank":5128,"name":"Mrpl37","annotation":"39S ribosomal protein L37, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL37 family."},{"id":"ENSMUSP00000142109","abundance":6.22,"rank":5129,"name":"Dag1","annotation":"Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] "},{"id":"ENSMUSP00000101071","abundance":6.21,"rank":5130,"name":"Zwint","annotation":"ZW10 interactor; Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase (By similarity)."},{"id":"ENSMUSP00000121042","abundance":6.21,"rank":5131,"name":"Dda1","annotation":"DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family."},{"id":"ENSMUSP00000055199","abundance":6.21,"rank":5132,"name":"Pcdh1","annotation":"Protocadherin 1."},{"id":"ENSMUSP00000097768","abundance":6.21,"rank":5133,"name":"Golga2","annotation":"Golgin subfamily A member 2; Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane. Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane. Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: [...] "},{"id":"ENSMUSP00000136527","abundance":6.21,"rank":5134,"name":"Spcs3","annotation":"Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum."},{"id":"ENSMUSP00000031311","abundance":6.2,"rank":5135,"name":"Dck","annotation":"Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA)."},{"id":"ENSMUSP00000034650","abundance":6.2,"rank":5136,"name":"Mcam","annotation":"Cell surface glycoprotein MUC18; Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration (By similarity)."},{"id":"ENSMUSP00000125623","abundance":6.19,"rank":5137,"name":"Ro60","annotation":"60 kDa SS-A/Ro ribonucleoprotein; RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation; Belongs to the Ro 60 kDa family."},{"id":"ENSMUSP00000082548","abundance":6.19,"rank":5138,"name":"Isg15","annotation":"Ubiquitin-like protein ISG15; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein. ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein. Its target proteins include SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, TRIM25, STAT5A, MAPK1/ERK2 and globin. Can also isgylate: DDX58/RIG-I which inhibits its function in antiviral sign [...] "},{"id":"ENSMUSP00000037251","abundance":6.19,"rank":5139,"name":"Dhx8","annotation":"ATP-dependent RNA helicase DHX8; Involved in pre-mRNA splicing as component of the spliceosome. Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome."},{"id":"ENSMUSP00000127539","abundance":6.19,"rank":5140,"name":"Myh15","annotation":"Myosin, heavy chain 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000033692","abundance":6.19,"rank":5141,"name":"Zcchc13","annotation":"Cellular nucleic acid binding-like protein."},{"id":"ENSMUSP00000151452","abundance":6.19,"rank":5142,"name":"Cited2","annotation":"Cbp/p300-interacting transactivator 2; Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts  [...] "},{"id":"ENSMUSP00000030784","abundance":6.18,"rank":5143,"name":"Prkag2","annotation":"5'-AMP-activated protein kinase subunit gamma-2; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a  [...] "},{"id":"ENSMUSP00000031806","abundance":6.18,"rank":5144,"name":"Cpa1","annotation":"Carboxypeptidase A1; Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro."},{"id":"ENSMUSP00000011526","abundance":6.17,"rank":5145,"name":"Dhdh","annotation":"Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase."},{"id":"ENSMUSP00000061317","abundance":6.17,"rank":5146,"name":"Vps53","annotation":"Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] "},{"id":"ENSMUSP00000109811","abundance":6.17,"rank":5147,"name":"Cyyr1","annotation":"Cysteine and tyrosine-rich protein 1."},{"id":"ENSMUSP00000019614","abundance":6.17,"rank":5148,"name":"Xab2","annotation":"Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing; Belongs to the crooked-neck family."},{"id":"ENSMUSP00000035610","abundance":6.16,"rank":5149,"name":"Sec23ip","annotation":"SEC23-interacting protein; Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P)."},{"id":"ENSMUSP00000036253","abundance":6.16,"rank":5150,"name":"Gorab","annotation":"RAB6-interacting golgin; Belongs to the GORAB family."},{"id":"ENSMUSP00000108691","abundance":6.16,"rank":5151,"name":"Cutal","annotation":"CutA divalent cation tolerance homolog-like."},{"id":"ENSMUSP00000024042","abundance":6.15,"rank":5152,"name":"Creld2","annotation":"Protein disulfide isomerase Creld2; Protein disulfide isomerase (Probable). Might play a role in the unfolded protein response (Probable). May regulate transport of alpha4-beta2 neuronal acetylcholine receptor (By similarity)."},{"id":"ENSMUSP00000041184","abundance":6.15,"rank":5153,"name":"Psmf1","annotation":"Proteasome inhibitor PI31 subunit; Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28 (By similarity)."},{"id":"ENSMUSP00000126763","abundance":6.15,"rank":5154,"name":"Gm20538","annotation":"Predicted gene 20538."},{"id":"ENSMUSP00000053923","abundance":6.14,"rank":5155,"name":"Chil3","annotation":"Chitinase-like protein 3; Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy."},{"id":"ENSMUSP00000108502","abundance":6.14,"rank":5156,"name":"D2hgdh","annotation":"D-2-hydroxyglutarate dehydrogenase, mitochondrial; Catalyzes the oxidation of D-2-hydroxyglutarate to alpha- ketoglutarate."},{"id":"ENSMUSP00000000219","abundance":6.14,"rank":5157,"name":"Th","annotation":"Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons."},{"id":"ENSMUSP00000159142","abundance":6.14,"rank":5158,"name":"Fam183b","annotation":"Protein FAM183B."},{"id":"ENSMUSP00000004202","abundance":6.13,"rank":5159,"name":"Dnmt1","annotation":"DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In a [...] "},{"id":"ENSMUSP00000118911","abundance":6.13,"rank":5160,"name":"Zfr","annotation":"Zinc finger RNA-binding protein; Involved in postimplantation and gastrulation stages of development. Binds to DNA and RNA. Involved in the nucleocytoplasmic shuttling of STAU2 (By similarity)."},{"id":"ENSMUSP00000041006","abundance":6.13,"rank":5161,"name":"Afp","annotation":"Alpha-fetoprotein; Binds estrogens, fatty acids and metals."},{"id":"ENSMUSP00000156669","abundance":6.13,"rank":5162,"name":"Erg","annotation":"Transcriptional regulator ERG; Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure."},{"id":"ENSMUSP00000034840","abundance":6.13,"rank":5163,"name":"Celf6","annotation":"CUGBP Elav-like family member 6; RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA (By similarity)."},{"id":"ENSMUSP00000058629","abundance":6.11,"rank":5164,"name":"Fzd1","annotation":"Frizzled-1; Receptor for Wnt proteins. Activated by WNT7B. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B (By similarity). Contradictory results showing activation by WNT7B have been described for mouse. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calciu [...] "},{"id":"ENSMUSP00000040220","abundance":6.11,"rank":5165,"name":"Ubac1","annotation":"Ubiquitin-associated domain-containing protein 1; Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity)."},{"id":"ENSMUSP00000021907","abundance":6.11,"rank":5166,"name":"Fbp2","annotation":"Fructose-1,6-bisphosphatase isozyme 2; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate."},{"id":"ENSMUSP00000147619","abundance":6.11,"rank":5167,"name":"Usp47","annotation":"Ubiquitin carboxyl-terminal hydrolase 47; Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER) (By similarity). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level."},{"id":"ENSMUSP00000021669","abundance":6.11,"rank":5168,"name":"Fcf1","annotation":"rRNA-processing protein FCF1 homolog; Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly; Belongs to the UTP23/FCF1 family. FCF1 subfamily."},{"id":"ENSMUSP00000003183","abundance":6.11,"rank":5169,"name":"Ppp5c","annotation":"Serine/threonine-protein phosphatase 5; Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Pa [...] "},{"id":"ENSMUSP00000025196","abundance":6.1,"rank":5170,"name":"Psmb8","annotation":"Proteasome subunit beta type-8; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the inflammatory response pathway. Required for adipocyte differentiation. May be involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleava [...] "},{"id":"ENSMUSP00000026539","abundance":6.1,"rank":5171,"name":"Fuom","annotation":"Fucose mutarotase; Involved in the interconversion between alpha- and beta-L- fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes."},{"id":"ENSMUSP00000053489","abundance":6.1,"rank":5172,"name":"Cxcr4","annotation":"C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Invo [...] "},{"id":"ENSMUSP00000025356","abundance":6.1,"rank":5173,"name":"Mal2","annotation":"Protein MAL2; Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity)."},{"id":"ENSMUSP00000054380","abundance":6.1,"rank":5174,"name":"Ercc2","annotation":"General transcription and DNA repair factor IIH helicase subunit XPD; ATP-dependent 5'-3' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. I [...] "},{"id":"ENSMUSP00000027444","abundance":6.1,"rank":5175,"name":"Pde6d","annotation":"Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E (By similarity). Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasin [...] "},{"id":"ENSMUSP00000076437","abundance":6.09,"rank":5176,"name":"Krt80","annotation":"Keratin, type II cytoskeletal 80; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000080427","abundance":6.09,"rank":5177,"name":"Ctnnd2","annotation":"Catenin delta-2; Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta- catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33."},{"id":"ENSMUSP00000087473","abundance":6.09,"rank":5178,"name":"Osbpl3","annotation":"Oxysterol-binding protein-related protein 3; Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 [...] "},{"id":"ENSMUSP00000140721","abundance":6.09,"rank":5179,"name":"Soat1","annotation":"Sterol O-acyltransferase 1; Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption; Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily."},{"id":"ENSMUSP00000128324","abundance":6.08,"rank":5180,"name":"Mfsd4b1","annotation":"Sodium-dependent glucose transporter 1A; May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney. Belongs to the major facilitator superfamily."},{"id":"ENSMUSP00000118015","abundance":6.08,"rank":5181,"name":"Ift20","annotation":"Intraflagellar transport protein 20 homolog; Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. Regulates the ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling. Essential for male fertility. Plays an important role in spermatogenesis, particular [...] "},{"id":"ENSMUSP00000025802","abundance":6.08,"rank":5182,"name":"Nudt8","annotation":"Nucleoside diphosphate-linked moiety X motif 8; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family."},{"id":"ENSMUSP00000078087","abundance":6.08,"rank":5183,"name":"Mapk7","annotation":"Mitogen-activated protein kinase 7; Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ER [...] "},{"id":"ENSMUSP00000028997","abundance":6.08,"rank":5184,"name":"Aurka","annotation":"Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for ini [...] "},{"id":"ENSMUSP00000025932","abundance":6.07,"rank":5185,"name":"Shoc2","annotation":"Leucine-rich repeat protein SHOC-2; Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes."},{"id":"ENSMUSP00000108151","abundance":6.07,"rank":5186,"name":"Pex5","annotation":"Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import."},{"id":"ENSMUSP00000101896","abundance":6.07,"rank":5187,"name":"Cant1","annotation":"Soluble calcium-activated nucleotidase 1; Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > IDP >> UTP > CDP = GTP = ITP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis; Belongs to the apyrase family."},{"id":"ENSMUSP00000084633","abundance":6.06,"rank":5188,"name":"Adam23","annotation":"Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity)."},{"id":"ENSMUSP00000022102","abundance":6.06,"rank":5189,"name":"Clptm1l","annotation":"Cleft lip and palate transmembrane protein 1-like protein; Enhances cisplatin-mediated apoptosis, when overexpressed. Belongs to the CLPTM1 family."},{"id":"ENSMUSP00000126773","abundance":6.06,"rank":5190,"name":"Ces2h","annotation":"Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000027567","abundance":6.06,"rank":5191,"name":"Serpinb3a","annotation":"Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A; Belongs to the serpin family."},{"id":"ENSMUSP00000079538","abundance":6.06,"rank":5192,"name":"Utp14a","annotation":"U3 small nucleolar RNA-associated protein 14 homolog A; May be required for ribosome biogenesis; Belongs to the UTP14 family."},{"id":"ENSMUSP00000018143","abundance":6.05,"rank":5193,"name":"Ddx27","annotation":"Probable ATP-dependent RNA helicase DDX27; Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA; Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily."},{"id":"ENSMUSP00000097604","abundance":6.05,"rank":5194,"name":"Ccdc50","annotation":"Coiled-coil domain-containing protein 50; Involved in EGFR signaling."},{"id":"ENSMUSP00000113835","abundance":6.05,"rank":5195,"name":"Paxbp1","annotation":"PAX3- and PAX7-binding protein 1; Adapter protein linking the transcription factors PAX3 and PAX7 to the histone methylation machinery and involved in myogenesis. Associates with a histone methyltransferase complex that specifically mediates dimethylation and trimethylation of 'Lys-4' of histone H3. Mediates the recruitment of that complex to the transcription factors PAX3 and PAX7 on chromatin to regulate the expression of genes involved in muscle progenitor cells proliferation including ID3 and CDC20. Belongs to the GCF family."},{"id":"ENSMUSP00000099615","abundance":6.04,"rank":5196,"name":"Dnajc24","annotation":"DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2)."},{"id":"ENSMUSP00000136247","abundance":6.04,"rank":5197,"name":"Ecsit","annotation":"Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial; Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development. Belongs to the ECSIT family."},{"id":"ENSMUSP00000041841","abundance":6.04,"rank":5198,"name":"Dnajc17","annotation":"DnaJ homolog subfamily C member 17; May negatively affect PAX8-induced thyroglobulin/TG transcription."},{"id":"ENSMUSP00000081956","abundance":6.04,"rank":5199,"name":"Gm45837","annotation":"Phosphodiesterase."},{"id":"ENSMUSP00000105300","abundance":6.04,"rank":5200,"name":"Spata48","annotation":"Spermatogenesis-associated protein 48."},{"id":"ENSMUSP00000037764","abundance":6.04,"rank":5201,"name":"Ypel5","annotation":"Protein yippee-like 5; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for normal cell proliferation (By similarity)."},{"id":"ENSMUSP00000083317","abundance":6.04,"rank":5202,"name":"Sult2a2","annotation":"Sulfotransferase; Belongs to the sulfotransferase 1 family."},{"id":"ENSMUSP00000049280","abundance":6.04,"rank":5203,"name":"Ccdc174","annotation":"Coiled-coil domain-containing protein 174; Probably involved in neuronal development."},{"id":"ENSMUSP00000108313","abundance":6.04,"rank":5204,"name":"Rif1","annotation":"Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1. Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair o [...] "},{"id":"ENSMUSP00000034529","abundance":6.03,"rank":5205,"name":"Cul5","annotation":"Cullin-5; Core component of multiple SCF-like ECS (Elongin BC-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimula [...] "},{"id":"ENSMUSP00000096994","abundance":6.03,"rank":5206,"name":"Nt5dc3","annotation":"5'-nucleotidase domain-containing protein 3."},{"id":"ENSMUSP00000021424","abundance":6.03,"rank":5207,"name":"Sptlc2","annotation":"Serine palmitoyltransferase 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate (By similarity). Plays an important role in de novo sphyngolipid biosynthesis which is crucial for adipogenesis."},{"id":"ENSMUSP00000101700","abundance":6.02,"rank":5208,"name":"Dlgap3","annotation":"Disks large-associated protein 3; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD- 95/SAP90 at the plasma membrane; Belongs to the SAPAP family."},{"id":"ENSMUSP00000068716","abundance":6.02,"rank":5209,"name":"Vps13a","annotation":"Vacuolar protein sorting-associated protein 13A; May play a role in the control of protein cycling through the trans-Golgi network to early and late endosomes, lysosomes and plasma membrane."},{"id":"ENSMUSP00000057462","abundance":6.02,"rank":5210,"name":"Vti1b","annotation":"Vesicle transport through interaction with t-SNAREs homolog 1B; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers."},{"id":"ENSMUSP00000081334","abundance":6.01,"rank":5211,"name":"Cldn19","annotation":"Claudin-19; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity."},{"id":"ENSMUSP00000124947","abundance":6.01,"rank":5212,"name":"Fnbp1l","annotation":"Formin-binding protein 1-like; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity)."},{"id":"ENSMUSP00000099529","abundance":6.01,"rank":5213,"name":"Sema6d","annotation":"Semaphorin-6D; Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity); Belongs to the semaphorin family."},{"id":"ENSMUSP00000153467","abundance":6,"rank":5214,"name":"Trip10","annotation":"Cdc42-interacting protein 4; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte [...] "},{"id":"ENSMUSP00000065277","abundance":5.99,"rank":5215,"name":"Serpinb2","annotation":"Plasminogen activator inhibitor 2, macrophage; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival; Belongs to the serpin family. Ov-serpin subfamily."},{"id":"ENSMUSP00000033509","abundance":5.99,"rank":5216,"name":"Ebp","annotation":"3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family."},{"id":"ENSMUSP00000032748","abundance":5.99,"rank":5217,"name":"Unc45a","annotation":"Protein unc-45 homolog A; May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen."},{"id":"ENSMUSP00000023464","abundance":5.98,"rank":5218,"name":"Meltf","annotation":"Melanotransferrin; Involved in iron cellular uptake. Seems to be internalized and then recycled back to the cell membrane. Binds a single atom of iron per subunit. Could also bind zinc; Belongs to the transferrin family."},{"id":"ENSMUSP00000036797","abundance":5.98,"rank":5219,"name":"Olig2","annotation":"Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development."},{"id":"ENSMUSP00000000958","abundance":5.98,"rank":5220,"name":"Top1mt","annotation":"DNA topoisomerase I, mitochondrial; Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, [...] "},{"id":"ENSMUSP00000050056","abundance":5.98,"rank":5221,"name":"Acy3","annotation":"N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming); Plays an important role in deacetylating mercapturic acids in kidney proximal tubules. Also acts on N-acetyl-aromatic amino acids."},{"id":"ENSMUSP00000127070","abundance":5.98,"rank":5222,"name":"Mybpc3","annotation":"Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role; Belongs to the immunoglobulin superfamily. MyBP family."},{"id":"ENSMUSP00000065832","abundance":5.97,"rank":5223,"name":"Cdkn1b","annotation":"Cyclin-dependent kinase inhibitor 1B; Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (By similarity). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. Belongs to the  [...] "},{"id":"ENSMUSP00000050464","abundance":5.96,"rank":5224,"name":"Cyp2j9","annotation":"Cytochrome P450, family 2, subfamily j, polypeptide 9; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000048101","abundance":5.96,"rank":5225,"name":"Nup88","annotation":"Nuclear pore complex protein Nup88; Component of nuclear pore complex."},{"id":"ENSMUSP00000013667","abundance":5.96,"rank":5226,"name":"Bcas1","annotation":"Breast carcinoma-amplified sequence 1 homolog; Required for myelination."},{"id":"ENSMUSP00000022522","abundance":5.96,"rank":5227,"name":"Tdh","annotation":"L-threonine 3-dehydrogenase, mitochondrial; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate, mediating L-threonine catabolism. Belongs to the NAD(P)-dependent epimerase/dehydratase family."},{"id":"ENSMUSP00000042285","abundance":5.95,"rank":5228,"name":"Ldah","annotation":"Lipid droplet-associated hydrolase; Serine lipid hydrolase associated with lipid droplets. Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages; Belongs to the AB hydrolase superfamily. LDAH family."},{"id":"ENSMUSP00000027817","abundance":5.95,"rank":5229,"name":"Spta1","annotation":"Spectrin alpha chain, erythrocytic 1; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane."},{"id":"ENSMUSP00000019945","abundance":5.95,"rank":5230,"name":"Pex3","annotation":"Peroxisomal biogenesis factor 3; Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes; Belongs to the peroxin-3 family."},{"id":"ENSMUSP00000088774","abundance":5.95,"rank":5231,"name":"Adamtsl2","annotation":"ADAMTS-like protein 2."},{"id":"ENSMUSP00000132918","abundance":5.95,"rank":5232,"name":"Omg","annotation":"Oligodendrocyte-myelin glycoprotein; Cell adhesion molecule contributing to the interactive process required for myelination in the central nervous system."},{"id":"ENSMUSP00000138695","abundance":5.94,"rank":5233,"name":"Sftpb","annotation":"Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter."},{"id":"ENSMUSP00000000312","abundance":5.94,"rank":5234,"name":"Cdh1","annotation":"Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 (By similarity).  (Microbial infection) Does not function as a receptor for L.monocytogenes internalin A (InlA); mutating a single surface-exposed residue confers recep [...] "},{"id":"ENSMUSP00000047567","abundance":5.94,"rank":5235,"name":"Sox5","annotation":"Transcription factor SOX-5; Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro."},{"id":"ENSMUSP00000098786","abundance":5.94,"rank":5236,"name":"Psen1","annotation":"Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity (By similarity). Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. Stimulates cell-cell adhesion via its interaction with CD [...] "},{"id":"ENSMUSP00000031250","abundance":5.94,"rank":5237,"name":"Nudt9","annotation":"ADP-ribose pyrophosphatase, mitochondrial; Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate; Belongs to the Nudix hydrolase family. NudF subfamily."},{"id":"ENSMUSP00000107677","abundance":5.94,"rank":5238,"name":"Zfp281","annotation":"Zinc finger protein 281; Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes."},{"id":"ENSMUSP00000101049","abundance":5.94,"rank":5239,"name":"Col18a1","annotation":"Collagen alpha-1(XVIII) chain; Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube.  Endostatin: Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. Inhibits VEGFA isoform VEGF165-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner [...] "},{"id":"ENSMUSP00000027816","abundance":5.93,"rank":5240,"name":"Mptx1","annotation":"Mucosal pentraxin; Belongs to the pentraxin family."},{"id":"ENSMUSP00000097601","abundance":5.93,"rank":5241,"name":"Fgf12","annotation":"Fibroblast growth factor 12; Involved in nervous system development and function. Promote neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation; Belongs to the heparin-binding growth factors family."},{"id":"ENSMUSP00000044129","abundance":5.92,"rank":5242,"name":"Trir","annotation":"Telomerase RNA component interacting RNase; Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to all four unpaired RNA nucleotides from 5' end or 3' end with higher efficiency for purine bases (By similarity)."},{"id":"ENSMUSP00000092135","abundance":5.92,"rank":5243,"name":"Ren1","annotation":"Renin-1; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney."},{"id":"ENSMUSP00000034763","abundance":5.91,"rank":5244,"name":"Rp9","annotation":"Retinitis pigmentosa 9 protein homolog; Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1."},{"id":"ENSMUSP00000020546","abundance":5.91,"rank":5245,"name":"Stc2","annotation":"Stanniocalcin-2; Has an anti-hypocalcemic action on calcium and phosphate homeostasis; Belongs to the stanniocalcin family."},{"id":"ENSMUSP00000109089","abundance":5.91,"rank":5246,"name":"Nrxn2","annotation":"Neurexin-2; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling."},{"id":"ENSMUSP00000042073","abundance":5.91,"rank":5247,"name":"Gnptg","annotation":"N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine-1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors."},{"id":"ENSMUSP00000115772","abundance":5.9,"rank":5248,"name":"Cnih4","annotation":"Protein cornichon homolog 4; Involved in G protein-coupled receptors (GPCRs) trafficking from the endoplasmic reticulum to the cell surface; it promotes the exit of GPCRs from the early secretory pathway, likely through interaction with the COPII machinery."},{"id":"ENSMUSP00000035910","abundance":5.9,"rank":5249,"name":"Fam170a","annotation":"Protein FAM170A; Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes. Binds to heat shock promoter elements (HSE)."},{"id":"ENSMUSP00000033999","abundance":5.89,"rank":5250,"name":"Frg1","annotation":"Protein FRG1; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B. Belongs to the FRG1 family."},{"id":"ENSMUSP00000044305","abundance":5.89,"rank":5251,"name":"Cdc40","annotation":"Pre-mRNA-processing factor 17; Required for pre-mRNA splicing as component of the activated spliceosome."},{"id":"ENSMUSP00000054226","abundance":5.89,"rank":5252,"name":"Mafa","annotation":"Transcription factor MafA; Transcriptional factor that activates insulin gene expression. Acts synergistically with NEUROD1/BETA2 and PDX1. Binds the insulin enhancer C1/RIPE3b element. Binds to consensus TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequence (By similarity)."},{"id":"ENSMUSP00000014957","abundance":5.89,"rank":5253,"name":"Stc1","annotation":"Stanniocalcin-1; Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia; Belongs to the stanniocalcin family."},{"id":"ENSMUSP00000049391","abundance":5.88,"rank":5254,"name":"Aox3","annotation":"Aldehyde oxidase 3; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with N [...] "},{"id":"ENSMUSP00000063329","abundance":5.88,"rank":5255,"name":"Kcnj3","annotation":"G protein-activated inward rectifier potassium channel 1; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating t [...] "},{"id":"ENSMUSP00000029645","abundance":5.88,"rank":5256,"name":"Tdo2","annotation":"Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety."},{"id":"ENSMUSP00000139219","abundance":5.88,"rank":5257,"name":"Meis1","annotation":"Homeobox protein Meis1; Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias; Belongs to the TALE/MEIS homeobox family."},{"id":"ENSMUSP00000053325","abundance":5.87,"rank":5258,"name":"Slc25a46","annotation":"Solute carrier family 25 member 46; May play a role in mitochondrial dynamics by controlling mitochondrial membrane fission."},{"id":"ENSMUSP00000009329","abundance":5.87,"rank":5259,"name":"Ccl8","annotation":"C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity)."},{"id":"ENSMUSP00000067710","abundance":5.87,"rank":5260,"name":"Serpinb9d","annotation":"Serine (Or cysteine) peptidase inhibitor, clade B, member 9D; Belongs to the serpin family."},{"id":"ENSMUSP00000103348","abundance":5.87,"rank":5261,"name":"Stx17","annotation":"Syntaxin-17; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate [...] "},{"id":"ENSMUSP00000027269","abundance":5.87,"rank":5262,"name":"Mstn","annotation":"Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth."},{"id":"ENSMUSP00000006508","abundance":5.87,"rank":5263,"name":"Ggt1","annotation":"Glutathione hydrolase 1 heavy chain; Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione [...] "},{"id":"ENSMUSP00000145373","abundance":5.87,"rank":5264,"name":"C2cd5","annotation":"C2 domain-containing protein 5; Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM."},{"id":"ENSMUSP00000050680","abundance":5.87,"rank":5265,"name":"Kcna3","annotation":"Potassium voltage-gated channel subfamily A member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient; Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.3/KCNA3 sub-subfamily."},{"id":"ENSMUSP00000015934","abundance":5.86,"rank":5266,"name":"Surf1","annotation":"Surfeit locus protein 1; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly."},{"id":"ENSMUSP00000021857","abundance":5.86,"rank":5267,"name":"Fars2","annotation":"Phenylalanine--tRNA ligase, mitochondrial; Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins (By similarity); Belongs to the class-II aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000020288","abundance":5.86,"rank":5268,"name":"Eif4ebp2","annotation":"Eukaryotic translation initiation factor 4E-binding protein 2; Repressor of translation initiation involved in synaptic plasticity, learning and memory formation. Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity  [...] "},{"id":"ENSMUSP00000085016","abundance":5.85,"rank":5269,"name":"Notch3","annotation":"Neurogenic locus notch homolog protein 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development."},{"id":"ENSMUSP00000036598","abundance":5.85,"rank":5270,"name":"Lgals2","annotation":"Galectin-2; This protein binds beta-galactoside. Its physiological function is not yet known."},{"id":"ENSMUSP00000031555","abundance":5.85,"rank":5271,"name":"Lfng","annotation":"Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (By similarity). Essential mediator of somite segmentation and patterning. During somite bound [...] "},{"id":"ENSMUSP00000156198","abundance":5.85,"rank":5272,"name":"D16Ertd472e","annotation":"Protein EURL homolog; Plays a role in cortical progenitor cell proliferation and differentiation. Promotes dendritic spine development of post-migratory cortical projection neurons by modulating the beta- catenin signaling pathway. Belongs to the EURL family."},{"id":"ENSMUSP00000104153","abundance":5.85,"rank":5273,"name":"Obox6","annotation":"Oocyte-specific homeobox 6."},{"id":"ENSMUSP00000002825","abundance":5.85,"rank":5274,"name":"Baz1b","annotation":"Tyrosine-protein kinase BAZ1B; Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates [...] "},{"id":"ENSMUSP00000098060","abundance":5.85,"rank":5275,"name":"Defb43","annotation":"Beta-defensin 43; Has bactericidal activity; Belongs to the beta-defensin family."},{"id":"ENSMUSP00000069932","abundance":5.84,"rank":5276,"name":"Cyp3a44","annotation":"Cytochrome P450, family 3, subfamily a, polypeptide 44."},{"id":"ENSMUSP00000091674","abundance":5.84,"rank":5277,"name":"Olfr558","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000052243","abundance":5.84,"rank":5278,"name":"Tctex1d4","annotation":"Tctex1 domain-containing protein 4."},{"id":"ENSMUSP00000113621","abundance":5.84,"rank":5279,"name":"Spg20","annotation":"Spartin; May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis."},{"id":"ENSMUSP00000120154","abundance":5.83,"rank":5280,"name":"Ggct","annotation":"Gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis."},{"id":"ENSMUSP00000119053","abundance":5.83,"rank":5281,"name":"1700021F05Rik","annotation":"Mitochondrial transcription rescue factor 1; Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability."},{"id":"ENSMUSP00000106561","abundance":5.82,"rank":5282,"name":"Taf6","annotation":"Transcription initiation factor TFIID subunit 6; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors (By similarity)."},{"id":"ENSMUSP00000029814","abundance":5.82,"rank":5283,"name":"Manba","annotation":"Beta-mannosidase; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides; Belongs to the glycosyl hydrolase 2 family."},{"id":"ENSMUSP00000022704","abundance":5.82,"rank":5284,"name":"Itm2b","annotation":"Integral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity).  Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers; Belongs to the ITM2 family."},{"id":"ENSMUSP00000128260","abundance":5.82,"rank":5285,"name":"Tfdp2","annotation":"Transcription factor Dp-2; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell- cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters."},{"id":"ENSMUSP00000099441","abundance":5.82,"rank":5286,"name":"Cdk5rap3","annotation":"CDK5 regulatory subunit-associated protein 3; Probable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation. Negatively regulates NF- kappa-B-mediated gene transcription through the control of RELA phosphorylation. Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint. Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation. May play a role in the unfol [...] "},{"id":"ENSMUSP00000022039","abundance":5.81,"rank":5287,"name":"Golm1","annotation":"Golgi membrane protein 1; Unknown. Cellular response protein to viral infection (By similarity)."},{"id":"ENSMUSP00000073873","abundance":5.81,"rank":5288,"name":"Nrm","annotation":"Nurim."},{"id":"ENSMUSP00000043401","abundance":5.81,"rank":5289,"name":"Ppip5k2","annotation":"Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2- InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylat [...] "},{"id":"ENSMUSP00000041282","abundance":5.8,"rank":5290,"name":"Map2k4","annotation":"Dual specificity mitogen-activated protein kinase kinase 4; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylati [...] "},{"id":"ENSMUSP00000002436","abundance":5.8,"rank":5291,"name":"Snx9","annotation":"Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin- independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promo [...] "},{"id":"ENSMUSP00000047569","abundance":5.8,"rank":5292,"name":"Card19","annotation":"Caspase recruitment domain-containing protein 19; Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B."},{"id":"ENSMUSP00000102748","abundance":5.8,"rank":5293,"name":"Cdkn2a","annotation":"Tumor suppressor ARF; Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcr [...] "},{"id":"ENSMUSP00000027797","abundance":5.79,"rank":5294,"name":"Nvl","annotation":"Nuclear valosin-containing protein-like; Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity."},{"id":"ENSMUSP00000002400","abundance":5.79,"rank":5295,"name":"Mdp1","annotation":"Magnesium-dependent phosphatase 1; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase."},{"id":"ENSMUSP00000030535","abundance":5.79,"rank":5296,"name":"Cda","annotation":"Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis."},{"id":"ENSMUSP00000104860","abundance":5.79,"rank":5297,"name":"Itk","annotation":"Tyrosine-protein kinase ITK/TSK; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the a [...] "},{"id":"ENSMUSP00000029769","abundance":5.79,"rank":5298,"name":"Gclm","annotation":"Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily."},{"id":"ENSMUSP00000033721","abundance":5.78,"rank":5299,"name":"Arhgap6","annotation":"Rho GTPase-activating protein 6; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology (By similarity)."},{"id":"ENSMUSP00000085799","abundance":5.78,"rank":5300,"name":"Slc38a1","annotation":"Sodium-coupled neutral amino acid transporter 1; Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA."},{"id":"ENSMUSP00000034699","abundance":5.78,"rank":5301,"name":"Scg3","annotation":"Secretogranin-3; Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity)."},{"id":"ENSMUSP00000102056","abundance":5.78,"rank":5302,"name":"Eif2b3","annotation":"Eukaryotic translation initiation factor 2B, subunit 3."},{"id":"ENSMUSP00000090230","abundance":5.78,"rank":5303,"name":"Ccdc43","annotation":"Coiled-coil domain-containing protein 43."},{"id":"ENSMUSP00000010502","abundance":5.77,"rank":5304,"name":"Ifi35","annotation":"Interferon-induced 35 kDa protein homolog."},{"id":"ENSMUSP00000113040","abundance":5.77,"rank":5305,"name":"Wwtr1","annotation":"WW domain-containing transcription regulator protein 1; Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances [...] "},{"id":"ENSMUSP00000127961","abundance":5.77,"rank":5306,"name":"Cep55","annotation":"Centrosomal protein of 55 kDa; Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney."},{"id":"ENSMUSP00000121846","abundance":5.77,"rank":5307,"name":"Spaca9","annotation":"Sperm acrosome-associated protein 9."},{"id":"ENSMUSP00000025925","abundance":5.77,"rank":5308,"name":"Plaat3","annotation":"Phospholipase A and acyltransferase 3; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2), catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity,catalyzing the calcium-independent transfer of [...] "},{"id":"ENSMUSP00000028935","abundance":5.76,"rank":5309,"name":"Cst9","annotation":"Cystatin-9; May be involved in testis development. May play a role in hematopoietic differentiation or inflammation (By similarity). Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria."},{"id":"ENSMUSP00000024827","abundance":5.76,"rank":5310,"name":"Tff3","annotation":"Trefoil factor 3; Involved in the maintenance and repair of the intestinal mucosa. Promotes the mobility of epithelial cells in healing processes (motogen)."},{"id":"ENSMUSP00000113097","abundance":5.76,"rank":5311,"name":"Orai1","annotation":"Calcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1. CRAC channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT; Belongs to the Orai family."},{"id":"ENSMUSP00000133100","abundance":5.76,"rank":5312,"name":"Olfr270","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000125580","abundance":5.76,"rank":5313,"name":"Phc1","annotation":"Polyhomeotic-like protein 1; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression (By similarity)."},{"id":"ENSMUSP00000030103","abundance":5.76,"rank":5314,"name":"Dmac1","annotation":"Distal membrane-arm assembly complex protein 1; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I."},{"id":"ENSMUSP00000016138","abundance":5.75,"rank":5315,"name":"Fnta","annotation":"Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic- aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation."},{"id":"ENSMUSP00000118890","abundance":5.75,"rank":5316,"name":"Repin1","annotation":"Replication initiator 1; Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'- ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending (By similarity)."},{"id":"ENSMUSP00000142363","abundance":5.75,"rank":5317,"name":"Zcchc8","annotation":"Zinc finger CCHC domain-containing protein 8; Scaffolding subunit of the trimeric nuclear exosome targeting (NEXT) complex. NEXT functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. May be involved in pre-mRNA splicing."},{"id":"ENSMUSP00000029682","abundance":5.75,"rank":5318,"name":"Thbs3","annotation":"Thrombospondin-3; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen."},{"id":"ENSMUSP00000049534","abundance":5.74,"rank":5319,"name":"Spn","annotation":"CD43 cytoplasmic tail; Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by  [...] "},{"id":"ENSMUSP00000111304","abundance":5.74,"rank":5320,"name":"Trmt2a","annotation":"tRNA (uracil-5-)-methyltransferase homolog A."},{"id":"ENSMUSP00000099824","abundance":5.74,"rank":5321,"name":"Cdkn2aipnl","annotation":"CDKN2AIP N-terminal-like protein."},{"id":"ENSMUSP00000099815","abundance":5.74,"rank":5322,"name":"Pkp4","annotation":"Plakophilin-4; Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques (By similarity). Belongs to the beta-catenin family."},{"id":"ENSMUSP00000005607","abundance":5.74,"rank":5323,"name":"Asf1b","annotation":"Histone chaperone ASF1B; Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA."},{"id":"ENSMUSP00000024031","abundance":5.74,"rank":5324,"name":"Acy1","annotation":"Aminoacylase-1; Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate); Belongs to the peptidase M20A family."},{"id":"ENSMUSP00000048441","abundance":5.73,"rank":5325,"name":"9530068E07Rik","annotation":"Keratinocyte-associated transmembrane protein 2."},{"id":"ENSMUSP00000035328","abundance":5.73,"rank":5326,"name":"Uba6","annotation":"Ubiquitin-like modifier-activating enzyme 6; Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34 (By similarity). Essential for embryonic development. Required for UBD/FAT10 conjugation."},{"id":"ENSMUSP00000085625","abundance":5.73,"rank":5327,"name":"Rab23","annotation":"Ras-related protein Rab-23; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with  [...] "},{"id":"ENSMUSP00000079239","abundance":5.73,"rank":5328,"name":"Mtss1","annotation":"Protein MTSS 1; Inhibits the nucleation of actin filaments in vitro."},{"id":"ENSMUSP00000031263","abundance":5.73,"rank":5329,"name":"Slc10a6","annotation":"Solute carrier family 10 member 6; Transports sulfoconjugated steroid hormones, as well as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a sodium-dependent manner."},{"id":"ENSMUSP00000153671","abundance":5.73,"rank":5330,"name":"Fdft1","annotation":"Squalene synthase; Critical branch point enzyme of isoprenoid biosynthesis that is thought to regulate the flux of isoprene intermediates through the sterol pathway; Belongs to the phytoene/squalene synthase family."},{"id":"ENSMUSP00000132256","abundance":5.73,"rank":5331,"name":"Usf2","annotation":"Upstream stimulatory factor 2; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters."},{"id":"ENSMUSP00000135978","abundance":5.72,"rank":5332,"name":"Dynlt1f","annotation":"Dynein light chain Tctex-type 1F."},{"id":"ENSMUSP00000137171","abundance":5.72,"rank":5333,"name":"Dynlt1b","annotation":"Dynein light chain Tctex-type 1B."},{"id":"ENSMUSP00000090644","abundance":5.72,"rank":5334,"name":"Dynlt1c","annotation":"Dynein light chain Tctex-type 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia (By similarity). May also be a accessory component of axonemal dynein. Plays an important role in  [...] "},{"id":"ENSMUSP00000127990","abundance":5.72,"rank":5335,"name":"Dynlt1a","annotation":"Dynein light chain Tctex-type 1A."},{"id":"ENSMUSP00000055299","abundance":5.72,"rank":5336,"name":"Tmem239","annotation":"Transmembrane protein 239."},{"id":"ENSMUSP00000111457","abundance":5.72,"rank":5337,"name":"Synj2","annotation":"Synaptojanin-2; Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (By similarity)."},{"id":"ENSMUSP00000033236","abundance":5.71,"rank":5338,"name":"Thumpd1","annotation":"THUMP domain-containing protein 1; Functions as a tRNA-binding adapter to mediate NAT10- dependent tRNA acetylation; Belongs to the THUMPD1 family."},{"id":"ENSMUSP00000009425","abundance":5.71,"rank":5339,"name":"Rarres2","annotation":"Retinoic acid receptor responder protein 2; Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine, causing an i [...] "},{"id":"ENSMUSP00000033477","abundance":5.71,"rank":5340,"name":"F9","annotation":"Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa."},{"id":"ENSMUSP00000076891","abundance":5.71,"rank":5341,"name":"Tmem268","annotation":"Transmembrane protein 268."},{"id":"ENSMUSP00000076157","abundance":5.71,"rank":5342,"name":"Zdhhc6","annotation":"Palmitoyltransferase ZDHHC6; Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (By similarity). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (By similarity). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Belongs to the DHHC palmitoyltransferase [...] "},{"id":"ENSMUSP00000108682","abundance":5.7,"rank":5343,"name":"Adamts7","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP."},{"id":"ENSMUSP00000030263","abundance":5.7,"rank":5344,"name":"St3gal3","annotation":"CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4- GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal- beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta- 1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc."},{"id":"ENSMUSP00000106720","abundance":5.7,"rank":5345,"name":"Znhit1","annotation":"Zinc finger HIT domain-containing protein 1; Seems to play a role in p53-mediated apoptosis induction (By similarity). Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity (By similarity); Belongs to the ZNHIT1 family."},{"id":"ENSMUSP00000101654","abundance":5.7,"rank":5346,"name":"Pkp3","annotation":"Plakophilin-3; May play a role in junctional plaques."},{"id":"ENSMUSP00000109130","abundance":5.7,"rank":5347,"name":"Men1","annotation":"Menin; Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoie [...] "},{"id":"ENSMUSP00000029454","abundance":5.7,"rank":5348,"name":"Casq2","annotation":"Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats."},{"id":"ENSMUSP00000031486","abundance":5.69,"rank":5349,"name":"Prkab1","annotation":"5'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] "},{"id":"ENSMUSP00000052905","abundance":5.69,"rank":5350,"name":"Eny2","annotation":"Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] "},{"id":"ENSMUSP00000033880","abundance":5.69,"rank":5351,"name":"Eif4ebp1","annotation":"Eukaryotic translation initiation factor 4E-binding protein 1; Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase a [...] "},{"id":"ENSMUSP00000103298","abundance":5.69,"rank":5352,"name":"Toporsl","annotation":"Topoisomerase I-binding, arginine/serine-rich-like."},{"id":"ENSMUSP00000053916","abundance":5.69,"rank":5353,"name":"Dnajb4","annotation":"DnaJ homolog subfamily B member 4; Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro)."},{"id":"ENSMUSP00000112675","abundance":5.69,"rank":5354,"name":"Ptpn2","annotation":"Tyrosine-protein phosphatase non-receptor type 2; Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the develop [...] "},{"id":"ENSMUSP00000039098","abundance":5.68,"rank":5355,"name":"Cnot3","annotation":"CCR4-NOT transcription complex subunit 3; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic  [...] "},{"id":"ENSMUSP00000012587","abundance":5.68,"rank":5356,"name":"Kif11","annotation":"Kinesin-like protein KIF11; Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily."},{"id":"ENSMUSP00000129696","abundance":5.67,"rank":5357,"name":"Sftpa1","annotation":"Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages ; Belongs to the SFTPA family."},{"id":"ENSMUSP00000068850","abundance":5.67,"rank":5358,"name":"Ptrh1","annotation":"Probable peptidyl-tRNA hydrolase."},{"id":"ENSMUSP00000035976","abundance":5.67,"rank":5359,"name":"Vax2","annotation":"Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina. Belongs to the EMX homeobox family."},{"id":"ENSMUSP00000158874","abundance":5.67,"rank":5360,"name":"Tmem205","annotation":"Transmembrane protein 205."},{"id":"ENSMUSP00000001715","abundance":5.67,"rank":5361,"name":"Gstt3","annotation":"Glutathione S-transferase theta-3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Shows high activity towards 4-nitrobenzyl chloride (4-NBC). Also has lower activity towards 1,2-epoxy-3-(p-nitrophenoxy)propane (EPNP), cumene hydroperoxide, 1- chloro-2,4-dinitrobenzene (CDNB), 7-chloro-4-nitrobenzo-2-oxa-1,3- diazole (NBD-Cl), and ethacrynic acid."},{"id":"ENSMUSP00000099820","abundance":5.67,"rank":5362,"name":"Stam2","annotation":"Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking process [...] "},{"id":"ENSMUSP00000082220","abundance":5.66,"rank":5363,"name":"Atp2c1","annotation":"Calcium-transporting ATPase type 2C member 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium."},{"id":"ENSMUSP00000005749","abundance":5.66,"rank":5364,"name":"Ctr9","annotation":"RNA polymerase-associated protein CTR9 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription [...] "},{"id":"ENSMUSP00000113588","abundance":5.66,"rank":5365,"name":"2610002M06Rik","annotation":"Charged multivesicular body protein 1b-2; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require t [...] "},{"id":"ENSMUSP00000147285","abundance":5.66,"rank":5366,"name":"Chmp1b","annotation":"Charged multivesicular body protein 1b-1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require t [...] "},{"id":"ENSMUSP00000063812","abundance":5.66,"rank":5367,"name":"Gabrg2","annotation":"Gamma-aminobutyric acid receptor subunit gamma-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The a [...] "},{"id":"ENSMUSP00000033608","abundance":5.66,"rank":5368,"name":"Sytl4","annotation":"Synaptotagmin-like protein 4; Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner."},{"id":"ENSMUSP00000049339","abundance":5.65,"rank":5369,"name":"Klk5","annotation":"Kallikrein-related-peptidase 5; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000021512","abundance":5.65,"rank":5370,"name":"Dhrs7","annotation":"Dehydrogenase/reductase SDR family member 7; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000061933","abundance":5.65,"rank":5371,"name":"D030056L22Rik","annotation":"Uncharacterized protein C9orf40 homolog."},{"id":"ENSMUSP00000072084","abundance":5.65,"rank":5372,"name":"Gckr","annotation":"Glucokinase regulatory protein; Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity)."},{"id":"ENSMUSP00000006851","abundance":5.65,"rank":5373,"name":"Qrich1","annotation":"Glutamine-rich protein 1."},{"id":"ENSMUSP00000030691","abundance":5.65,"rank":5374,"name":"Pclo","annotation":"Protein piccolo; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Organizes as well [...] "},{"id":"ENSMUSP00000020957","abundance":5.65,"rank":5375,"name":"Adi1","annotation":"1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14; Belongs to the acireductone dioxygenase (ARD) family."},{"id":"ENSMUSP00000041082","abundance":5.64,"rank":5376,"name":"Rgl2","annotation":"Ral guanine nucleotide dissociation stimulator-like 2; Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro."},{"id":"ENSMUSP00000102796","abundance":5.64,"rank":5377,"name":"Adamtsl1","annotation":"ADAMTS-like protein 1."},{"id":"ENSMUSP00000047570","abundance":5.64,"rank":5378,"name":"Jmjd6","annotation":"Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6; Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5- hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5- hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by it [...] "},{"id":"ENSMUSP00000092468","abundance":5.64,"rank":5379,"name":"Zfp787","annotation":"Zinc finger protein 787; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000031622","abundance":5.64,"rank":5380,"name":"Ocm","annotation":"Oncomodulin; Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions; Belongs to the parvalbumin family."},{"id":"ENSMUSP00000053727","abundance":5.64,"rank":5381,"name":"Coa4","annotation":"Cytochrome c oxidase assembly factor 4 homolog, mitochondrial; Putative COX assembly factor; Belongs to the COA4 family."},{"id":"ENSMUSP00000140603","abundance":5.64,"rank":5382,"name":"Dcdc2c","annotation":"Doublecortin domain-containing protein 2C."},{"id":"ENSMUSP00000135750","abundance":5.63,"rank":5383,"name":"Zfp428","annotation":"Zinc finger protein 428."},{"id":"ENSMUSP00000110550","abundance":5.63,"rank":5384,"name":"Zc3hav1","annotation":"Zinc finger CCCH-type antiviral protein 1; Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the [...] "},{"id":"ENSMUSP00000007754","abundance":5.62,"rank":5385,"name":"Gtpbp3","annotation":"tRNA modification GTPase GTPBP3, mitochondrial; GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family."},{"id":"ENSMUSP00000062016","abundance":5.62,"rank":5386,"name":"B4gat1","annotation":"Beta-1,4-glucuronyltransferase 1; Beta-1,4-glucuronyltransferase involved in O-mannosylation of alpha-dystroglycan (DAG1). Transfers a glucuronic acid (GlcA) residue onto a xylose (Xyl) acceptor to produce the glucuronyl-beta-1,4-xylose- beta disaccharide primer, which is further elongated by LARGE1, during synthesis of phosphorylated O-mannosyl glycan. Phosphorylated O- mannosyl glycan is a carbohydrate is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G- like domain-containing extracellular proteins with high affinity. Required fo [...] "},{"id":"ENSMUSP00000152796","abundance":5.62,"rank":5387,"name":"Sirt5","annotation":"NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (By similarity). Activates SHMT2 by mediating [...] "},{"id":"ENSMUSP00000097170","abundance":5.62,"rank":5388,"name":"Grem1","annotation":"Gremlin-1; Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (By similarity)."},{"id":"ENSMUSP00000026661","abundance":5.62,"rank":5389,"name":"Tk1","annotation":"Thymidine kinase, cytosolic."},{"id":"ENSMUSP00000044604","abundance":5.62,"rank":5390,"name":"Aaas","annotation":"Aladin; Plays a role in the normal development of the peripheral and central nervous system. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment."},{"id":"ENSMUSP00000078630","abundance":5.61,"rank":5391,"name":"Gss","annotation":"Glutathione synthetase; Belongs to the eukaryotic GSH synthase family."},{"id":"ENSMUSP00000032376","abundance":5.61,"rank":5392,"name":"Lmcd1","annotation":"LIM and cysteine-rich domains protein 1; Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6- mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway."},{"id":"ENSMUSP00000042260","abundance":5.61,"rank":5393,"name":"Ncapd2","annotation":"Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely in [...] "},{"id":"ENSMUSP00000092216","abundance":5.6,"rank":5394,"name":"Sars2","annotation":"Serine--tRNA ligase, mitochondrial; Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec); Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily."},{"id":"ENSMUSP00000081998","abundance":5.6,"rank":5395,"name":"Pgm2l1","annotation":"Glucose 1,6-bisphosphate synthase; Glucose 1,6-bisphosphate synthase using 1,3- bisphosphoglycerate as a phosphate donor and a series of 1-phosphate sugars as acceptors, including glucose 1-phosphate, mannose 1- phosphate, ribose 1-phosphate and deoxyribose 1-phosphate. 5 or 6- phosphosugars are bad substrates, with the exception of glucose 6- phosphate. Also synthesizes ribose 1,5-bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities (By similarity)."},{"id":"ENSMUSP00000155861","abundance":5.6,"rank":5396,"name":"Ppil2","annotation":"RING-type E3 ubiquitin-protein ligase PPIL2; Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity."},{"id":"ENSMUSP00000000451","abundance":5.6,"rank":5397,"name":"Raf1","annotation":"RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal- regulated kin [...] "},{"id":"ENSMUSP00000003310","abundance":5.59,"rank":5398,"name":"Ranbp2","annotation":"E3 SUMO-protein ligase RanBP2; E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single- stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1 (By similarity). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuc [...] "},{"id":"ENSMUSP00000008907","abundance":5.59,"rank":5399,"name":"Man1a2","annotation":"Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2); Belongs to the glycosyl hydrolase 47 family."},{"id":"ENSMUSP00000099532","abundance":5.59,"rank":5400,"name":"Tmem97","annotation":"Sigma intracellular receptor 2; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins."},{"id":"ENSMUSP00000078971","abundance":5.58,"rank":5401,"name":"Slc27a4","annotation":"Long-chain fatty acid transport protein 4; Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones. Belongs to the  [...] "},{"id":"ENSMUSP00000034393","abundance":5.58,"rank":5402,"name":"Tmed6","annotation":"Transmembrane emp24 domain-containing protein 6."},{"id":"ENSMUSP00000032967","abundance":5.57,"rank":5403,"name":"Lipt2","annotation":"Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes, which catalyze essential redox reactions (By similarity). Lipoyl-ACP can also act as a substrate although octanoyl- ACP is likely to be the physiological substrate (By similarity)."},{"id":"ENSMUSP00000127487","abundance":5.57,"rank":5404,"name":"Tnxb","annotation":"Tenascin XB."},{"id":"ENSMUSP00000058968","abundance":5.57,"rank":5405,"name":"Dcun1d3","annotation":"DCN1-like protein 3; Antagonizes DCUN1D1-mediated CUL1 neddylation by sequestering CUL1 at the cell membrane."},{"id":"ENSMUSP00000078593","abundance":5.57,"rank":5406,"name":"1190007I07Rik","annotation":"Uncharacterized protein C12orf73 homolog."},{"id":"ENSMUSP00000108553","abundance":5.56,"rank":5407,"name":"Col4a5","annotation":"Collagen, type IV, alpha 5."},{"id":"ENSMUSP00000083146","abundance":5.56,"rank":5408,"name":"Bud23","annotation":"Probable 18S rRNA (guanine-N(7))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA- modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactiva [...] "},{"id":"ENSMUSP00000108326","abundance":5.56,"rank":5409,"name":"Serpinb8","annotation":"Serpin B8; Has an important role in epithelial desmosome-mediated cell- cell adhesion; Belongs to the serpin family. Ov-serpin subfamily."},{"id":"ENSMUSP00000020928","abundance":5.56,"rank":5410,"name":"Arsg","annotation":"Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family."},{"id":"ENSMUSP00000088801","abundance":5.56,"rank":5411,"name":"Mfn1","annotation":"Mitofusin-1; Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity (By similarity). It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity (By similarity). Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily."},{"id":"ENSMUSP00000027421","abundance":5.56,"rank":5412,"name":"Trip12","annotation":"E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] "},{"id":"ENSMUSP00000135639","abundance":5.55,"rank":5413,"name":"Tcof1","annotation":"Treacle protein; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification."},{"id":"ENSMUSP00000020420","abundance":5.55,"rank":5414,"name":"Ap3d1","annotation":"AP-3 complex subunit delta-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes (By similarity). Involved in process of CD8+ T-cell and NK cell degranulation (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals."},{"id":"ENSMUSP00000078132","abundance":5.55,"rank":5415,"name":"Nmral1","annotation":"NmrA-like family domain-containing protein 1; Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer b [...] "},{"id":"ENSMUSP00000047766","abundance":5.55,"rank":5416,"name":"H2-M10.5","annotation":"Histocompatibility 2, M region locus 10.5; Belongs to the MHC class I family."},{"id":"ENSMUSP00000088845","abundance":5.55,"rank":5417,"name":"Cdk7","annotation":"Cyclin-dependent kinase 7; Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating  [...] "},{"id":"ENSMUSP00000006760","abundance":5.55,"rank":5418,"name":"Cdt1","annotation":"DNA replication factor Cdt1; Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini- chromosome maintenance (MCM) complex onto DNA to generate pre- replication complexes (pre-RC). Required also for mitosis by promoting stable kinetochore-microtubule attachments (By similarity). Potential oncogene. Belongs to the Cdt1 family."},{"id":"ENSMUSP00000075992","abundance":5.55,"rank":5419,"name":"Ikzf1","annotation":"DNA-binding protein Ikaros; Transcription regulator of hematopoietic cell differentiation. Binds gamma-satellite DNA. Binds with higher affinity to gamma satellite A. Plays a role in the development of lymphocytes, B- and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (terminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single compl [...] "},{"id":"ENSMUSP00000035129","abundance":5.54,"rank":5420,"name":"Ephb1","annotation":"Ephrin type-B receptor 1; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotempora [...] "},{"id":"ENSMUSP00000073790","abundance":5.54,"rank":5421,"name":"Myo5b","annotation":"Unconventional myosin-Vb; May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis; Belongs to the TRAFAC cla [...] "},{"id":"ENSMUSP00000058279","abundance":5.54,"rank":5422,"name":"Coa6","annotation":"Cytochrome c oxidase assembly factor 6 homolog; Involved in the maturation of the mitochondrial respiratory chain complex IV subunit MT-CO2/COX2. Thereby, may regulate early steps of complex IV assembly. Mitochondrial respiratory chain complex IV or cytochrome c oxidase is the component of the respiratory chain that catalyzes the transfer of electrons from intermembrane space cytochrome c to molecular oxygen in the matrix and as a consequence contributes to the proton gradient involved in mitochondrial ATP synthesis. May also be required for efficient formation of respiratory supercomp [...] "},{"id":"ENSMUSP00000010278","abundance":5.54,"rank":5423,"name":"Wdr77","annotation":"Methylosome protein 50; Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-contain [...] "},{"id":"ENSMUSP00000107512","abundance":5.54,"rank":5424,"name":"Nfkb2","annotation":"Nuclear factor NF-kappa-B p100 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the indi [...] "},{"id":"ENSMUSP00000067579","abundance":5.53,"rank":5425,"name":"Rcl1","annotation":"RNA 3'-terminal phosphate cyclase-like protein; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity); Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily."},{"id":"ENSMUSP00000020273","abundance":5.53,"rank":5426,"name":"Supv3l1","annotation":"ATP-dependent RNA helicase SUPV3L1, mitochondrial; Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (By similarity). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in m [...] "},{"id":"ENSMUSP00000088491","abundance":5.53,"rank":5427,"name":"Bcan","annotation":"Brevican core protein; May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans."},{"id":"ENSMUSP00000110348","abundance":5.53,"rank":5428,"name":"Agbl5","annotation":"Cytosolic carboxypeptidase-like protein 5; Metallocarboxypeptidase that mediates protein deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/CCP1, AGBL2/CCP2, AGBL3/CCP3, AGBL1/CCP4 and AGBL4/CCP6. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS."},{"id":"ENSMUSP00000005841","abundance":5.53,"rank":5429,"name":"Ctcf","annotation":"Transcriptional repressor CTCF; Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by ac [...] "},{"id":"ENSMUSP00000025305","abundance":5.52,"rank":5430,"name":"Mrps18b","annotation":"28S ribosomal protein S18b, mitochondrial."},{"id":"ENSMUSP00000102952","abundance":5.52,"rank":5431,"name":"S100a5","annotation":"Protein S100-A5; Binds calcium, zinc and copper. One subunit can simultaneously bind 2 calcium ions or 2 copper ions plus 1 zinc ion. Calcium and copper ions compete for the same binding sites (By similarity); Belongs to the S-100 family."},{"id":"ENSMUSP00000023726","abundance":5.52,"rank":5432,"name":"Lalba","annotation":"Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N- acetylglucosamine of the oligosaccharide chains in glycoproteins."},{"id":"ENSMUSP00000074188","abundance":5.52,"rank":5433,"name":"Cd302","annotation":"CD302 antigen; Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration."},{"id":"ENSMUSP00000040580","abundance":5.52,"rank":5434,"name":"Galm","annotation":"Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)."},{"id":"ENSMUSP00000039853","abundance":5.51,"rank":5435,"name":"Rrp12","annotation":"RRP12-like protein."},{"id":"ENSMUSP00000036270","abundance":5.51,"rank":5436,"name":"Vav3","annotation":"Guanine nucleotide exchange factor VAV3; Exchange factor for GTP-binding proteins RhoA, RhoG and, to a lesser extent, Rac1. Binds physically to the nucleotide-free states of those GTPases (By similarity). Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May be important for integrin-mediated signaling, at least in some cell types. In osteoclasts, along with SYK tyrosine kinase, required for signaling through integrin alpha-v/beta-1 (ITAGV-ITGB1), a  [...] "},{"id":"ENSMUSP00000021653","abundance":5.51,"rank":5437,"name":"Acot3","annotation":"Acyl-coenzyme A thioesterase 3; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-CoA thioesterase 3/ACOT3 is mainly active on long-chain acyl-CoAs. May have a function in termination of beta-oxidation of fatty acids. Belongs to the C/M/P thioester hydrolase family."},{"id":"ENSMUSP00000042918","abundance":5.51,"rank":5438,"name":"Ccdc115","annotation":"Coiled-coil domain-containing protein 115; Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity)."},{"id":"ENSMUSP00000062326","abundance":5.5,"rank":5439,"name":"Mrps27","annotation":"28S ribosomal protein S27, mitochondrial; RNA-binding component of the mitochondrial small ribosomal subunit (mt-SSU) that plays a role in mitochondrial protein synthesis. Stimulates mitochondrial mRNA translation of subunit components of the mitochondrial electron transport chain. Binds to the mitochondrial 12S rRNA (12S mt-rRNA) and tRNA(Glu). Overexpressed in hepatocellular carcinoma tissues compared with adjacent non-tumoral liver tissues."},{"id":"ENSMUSP00000113974","abundance":5.5,"rank":5440,"name":"Zcchc2","annotation":"Zinc finger CCHC domain-containing protein 2."},{"id":"ENSMUSP00000045221","abundance":5.5,"rank":5441,"name":"Svs1","annotation":"Amine oxidase; Belongs to the copper/topaquinone oxidase family."},{"id":"ENSMUSP00000029738","abundance":5.5,"rank":5442,"name":"Gpr89","annotation":"Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance."},{"id":"ENSMUSP00000006104","abundance":5.5,"rank":5443,"name":"P2rx5","annotation":"P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel."},{"id":"ENSMUSP00000096386","abundance":5.5,"rank":5444,"name":"Zc3h4","annotation":"Zinc finger CCCH domain-containing protein 4."},{"id":"ENSMUSP00000122056","abundance":5.49,"rank":5445,"name":"Dnajb12","annotation":"DnaJ homolog subfamily B member 12; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum- associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB14, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of na [...] "},{"id":"ENSMUSP00000024978","abundance":5.48,"rank":5446,"name":"Nme3","annotation":"Nucleoside diphosphate kinase 3; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis (By similarity); Belongs to the NDK family."},{"id":"ENSMUSP00000079198","abundance":5.48,"rank":5447,"name":"Oas1a","annotation":"2'-5'-oligoadenylate synthase 1A; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition [...] "},{"id":"ENSMUSP00000026577","abundance":5.48,"rank":5448,"name":"Eps8l2","annotation":"Epidermal growth factor receptor kinase substrate 8-like protein 2; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). In the cochlea, is required for stereocilia maintenance in adult hair cells ; Belongs to the EPS8 family."},{"id":"ENSMUSP00000063999","abundance":5.48,"rank":5449,"name":"Kidins220","annotation":"Kinase D-interacting substrate 220."},{"id":"ENSMUSP00000150331","abundance":5.47,"rank":5450,"name":"Olfr1288","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000074818","abundance":5.47,"rank":5451,"name":"Pip","annotation":"Prolactin-inducible protein homolog."},{"id":"ENSMUSP00000122212","abundance":5.47,"rank":5452,"name":"Gm12666","annotation":"Predicted gene 12666."},{"id":"ENSMUSP00000023775","abundance":5.47,"rank":5453,"name":"Cela1","annotation":"Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily."},{"id":"ENSMUSP00000124881","abundance":5.47,"rank":5454,"name":"Ermp1","annotation":"Endoplasmic reticulum metallopeptidase 1; Within the ovary, required for the organization of somatic cells and oocytes into discrete follicular structures. Belongs to the peptidase M28 family."},{"id":"ENSMUSP00000101657","abundance":5.46,"rank":5455,"name":"Ifitm1","annotation":"Interferon-induced transmembrane protein 1; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also  [...] "},{"id":"ENSMUSP00000108582","abundance":5.46,"rank":5456,"name":"Kif1a","annotation":"Kinesin-like protein KIF1A; Motor for anterograde axonal transport of synaptic vesicle precursors (Probable). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily."},{"id":"ENSMUSP00000086095","abundance":5.46,"rank":5457,"name":"Ncaph2","annotation":"Condensin-2 complex subunit H2; Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (By similarity). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at an [...] "},{"id":"ENSMUSP00000045527","abundance":5.46,"rank":5458,"name":"Cdk10","annotation":"Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."},{"id":"ENSMUSP00000020826","abundance":5.46,"rank":5459,"name":"Sap30l","annotation":"Histone deacetylase complex subunit SAP30L; Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence- specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import. Belongs to the SAP30 family."},{"id":"ENSMUSP00000108499","abundance":5.46,"rank":5460,"name":"Chrdl1","annotation":"Chordin-like protein 1; Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior [...] "},{"id":"ENSMUSP00000021652","abundance":5.46,"rank":5461,"name":"Acot4","annotation":"Peroxisomal succinyl-coenzyme A thioesterase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. In contrast to human peroxisomal succinyl-coenzyme A thioesterase/ACOT4, mouse ACOT4 is essentially a succinyl-CoA thioesterase with no activity with medium to long chain saturated acyl- CoAs and with a low activity toward glutaryl-CoA. Belongs to the C/M/P thioester hydrolase family."},{"id":"ENSMUSP00000103534","abundance":5.46,"rank":5462,"name":"Elobl","annotation":"Elongin B-like."},{"id":"ENSMUSP00000025394","abundance":5.45,"rank":5463,"name":"Sec11c","annotation":"Signal peptidase complex catalytic subunit SEC11C; Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum."},{"id":"ENSMUSP00000027451","abundance":5.45,"rank":5464,"name":"Epha4","annotation":"Ephrin type-A receptor 4; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. U [...] "},{"id":"ENSMUSP00000074659","abundance":5.45,"rank":5465,"name":"Klk1","annotation":"Kallikrein-1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000131029","abundance":5.45,"rank":5466,"name":"Keap1","annotation":"Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] "},{"id":"ENSMUSP00000059570","abundance":5.44,"rank":5467,"name":"Lrrc3","annotation":"Leucine-rich repeat-containing protein 3."},{"id":"ENSMUSP00000099706","abundance":5.44,"rank":5468,"name":"Selenoh","annotation":"Selenoprotein H; May be involved in a redox-related process."},{"id":"ENSMUSP00000127853","abundance":5.44,"rank":5469,"name":"Lyrm9","annotation":"LYR motif-containing protein 9; Belongs to the complex I LYR family. LYRM9 subfamily."},{"id":"ENSMUSP00000154853","abundance":5.44,"rank":5470,"name":"St3gal1","annotation":"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; Responsible for the synthesis of the sequence NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- found on sugar chains O-linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values."},{"id":"ENSMUSP00000125373","abundance":5.43,"rank":5471,"name":"Plod2","annotation":"Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links."},{"id":"ENSMUSP00000037546","abundance":5.43,"rank":5472,"name":"Letmd1","annotation":"LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53."},{"id":"ENSMUSP00000099392","abundance":5.43,"rank":5473,"name":"Matn4","annotation":"Matrilin-4; Major component of the extracellular matrix of cartilage."},{"id":"ENSMUSP00000024731","abundance":5.43,"rank":5474,"name":"Spats1","annotation":"Spermatogenesis-associated serine-rich protein 1."},{"id":"ENSMUSP00000082354","abundance":5.43,"rank":5475,"name":"Mthfs","annotation":"5-formyltetrahydrofolate cyclo-ligase; Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids. Catalyzes the irreversible conversion of 5- formyltetrahydrofolate (5-CHO-H(4)PteGlu) to yield 5,10- methenyltetrahydrofolate (By similarity)."},{"id":"ENSMUSP00000025178","abundance":5.42,"rank":5476,"name":"Vps52","annotation":"Vacuolar protein sorting-associated protein 52 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] "},{"id":"ENSMUSP00000019220","abundance":5.42,"rank":5477,"name":"Strn4","annotation":"Striatin-4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family."},{"id":"ENSMUSP00000037028","abundance":5.42,"rank":5478,"name":"Camk1d","annotation":"Calcium/calmodulin-dependent protein kinase type 1D; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of eryth [...] "},{"id":"ENSMUSP00000069078","abundance":5.42,"rank":5479,"name":"Commd4","annotation":"COMM domain-containing protein 4; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Down-regulates activation of NF-kappa-B."},{"id":"ENSMUSP00000026846","abundance":5.42,"rank":5480,"name":"Tyms","annotation":"Thymidylate synthase; Contributes to the de novo mitochondrial thymidylate biosynthesis pathway."},{"id":"ENSMUSP00000024757","abundance":5.41,"rank":5481,"name":"Enpp4","annotation":"Bis(5'-adenosyl)-triphosphatase enpp4; Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity)."},{"id":"ENSMUSP00000056669","abundance":5.41,"rank":5482,"name":"Cd14","annotation":"Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] "},{"id":"ENSMUSP00000014562","abundance":5.41,"rank":5483,"name":"Hps5","annotation":"Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins. Belongs to the HPS5 family."},{"id":"ENSMUSP00000022815","abundance":5.41,"rank":5484,"name":"Ngdn","annotation":"Neuroguidin; Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner; Belongs to the SAS10 family."},{"id":"ENSMUSP00000085921","abundance":5.41,"rank":5485,"name":"Pex26","annotation":"Peroxisome assembly protein 26; Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence (By similarity); Belongs to the peroxin-26 family."},{"id":"ENSMUSP00000086027","abundance":5.41,"rank":5486,"name":"Htatsf1","annotation":"HIV Tat-specific factor 1 homolog; Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation (By similarity)."},{"id":"ENSMUSP00000038126","abundance":5.41,"rank":5487,"name":"Metrnl","annotation":"Meteorin-like protein; Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates a [...] "},{"id":"ENSMUSP00000102980","abundance":5.41,"rank":5488,"name":"Stat5a","annotation":"Signal transducer and activator of transcription."},{"id":"ENSMUSP00000037222","abundance":5.4,"rank":5489,"name":"Catsper2","annotation":"Cation channel sperm-associated protein 2; Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization."},{"id":"ENSMUSP00000072865","abundance":5.4,"rank":5490,"name":"Olfr871","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000028010","abundance":5.4,"rank":5491,"name":"Fmo3","annotation":"Dimethylaniline monooxygenase [N-oxide-forming] 3; Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thr [...] "},{"id":"ENSMUSP00000070261","abundance":5.4,"rank":5492,"name":"B630019K06Rik","annotation":"RIKEN cDNA B630019K06 gene."},{"id":"ENSMUSP00000065966","abundance":5.4,"rank":5493,"name":"Amelx","annotation":"Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel."},{"id":"ENSMUSP00000065819","abundance":5.4,"rank":5494,"name":"Thoc7","annotation":"THO complex subunit 7 homolog; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm v [...] "},{"id":"ENSMUSP00000035170","abundance":5.39,"rank":5495,"name":"Dnajc13","annotation":"DnaJ heat shock protein family (Hsp40) member C13."},{"id":"ENSMUSP00000144122","abundance":5.39,"rank":5496,"name":"Rbm47","annotation":"RNA-binding protein 47; Belongs to the RRM RBM47 family."},{"id":"ENSMUSP00000097780","abundance":5.39,"rank":5497,"name":"Larp4","annotation":"La-related protein 4; RNA binding protein that binds to the poly-A tract of mRNA molecules. Associates with the 40S ribosomal subunit and with polysomes. Plays a role in the regulation of mRNA translation. Plays a role in the regulation of cell morphology and cytoskeletal organization."},{"id":"ENSMUSP00000085734","abundance":5.39,"rank":5498,"name":"Srpk2","annotation":"SRSF protein kinase 2 C-terminal; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates  [...] "},{"id":"ENSMUSP00000054595","abundance":5.39,"rank":5499,"name":"Zfp13","annotation":"Zinc finger protein 13; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000155139","abundance":5.39,"rank":5500,"name":"Tsta3","annotation":"GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction."},{"id":"ENSMUSP00000072636","abundance":5.38,"rank":5501,"name":"Scfd2","annotation":"Sec1 family domain-containing protein 2; May be involved in protein transport; Belongs to the STXBP/unc-18/SEC1 family."},{"id":"ENSMUSP00000037809","abundance":5.38,"rank":5502,"name":"Ubald1","annotation":"UBA-like domain-containing protein 1; Belongs to the UBALD family."},{"id":"ENSMUSP00000133694","abundance":5.38,"rank":5503,"name":"Mocs1","annotation":"Cyclic pyranopterin monophosphate synthase; Isoform Mocs1a and isoform Mocs1b probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). Mocs1a catalyzes the cyclization of GTP to (8S)- 3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and Mocs1b catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'- triphosphate to cPMP; In the C-terminal section; belongs to the MoaC family."},{"id":"ENSMUSP00000043302","abundance":5.38,"rank":5504,"name":"Ptger3","annotation":"Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal ur [...] "},{"id":"ENSMUSP00000082816","abundance":5.38,"rank":5505,"name":"Pml","annotation":"Protein PML; Functions via its association with PML-nuclear bodies (PML- NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosphorylation and by inhibiting its MDM2-dependent degradation). Regulates phosph [...] "},{"id":"ENSMUSP00000020755","abundance":5.37,"rank":5506,"name":"Ppp4r3b","annotation":"Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers (By similarity); Belongs to the SMEK family."},{"id":"ENSMUSP00000140727","abundance":5.37,"rank":5507,"name":"Nipsnap3a","annotation":"Nipsnap homolog 3A."},{"id":"ENSMUSP00000073579","abundance":5.37,"rank":5508,"name":"2810021J22Rik","annotation":"RIKEN cDNA 2810021J22 gene."},{"id":"ENSMUSP00000042277","abundance":5.36,"rank":5509,"name":"Cybc1","annotation":"Cytochrome b-245 chaperone 1; Necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer. Controls the phagocyte respiratory burst and is essential for innate immunity. Belongs to the CYBC1 family."},{"id":"ENSMUSP00000074675","abundance":5.36,"rank":5510,"name":"Plekha1","annotation":"Pleckstrin homology domain-containing family A member 1; Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane (By similarity)."},{"id":"ENSMUSP00000043865","abundance":5.36,"rank":5511,"name":"Ubash3b","annotation":"Ubiquitin-associated and SH3 domain-containing protein B; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination."},{"id":"ENSMUSP00000025567","abundance":5.36,"rank":5512,"name":"Fads2","annotation":"Acyl-CoA 6-desaturase; Acts as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively. Subsequently, in the biosynthetic pathway of HUFA [...] "},{"id":"ENSMUSP00000127245","abundance":5.36,"rank":5513,"name":"Sv2b","annotation":"Synaptic vesicle glycoprotein 2B; Probably plays a role in the control of regulated secretion in neural and endocrine cells. (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD). Not a receptor for C.botulinum neurotoxin type D (BoNT/D, botD). Belongs to the major facilitator superfamily."},{"id":"ENSMUSP00000070825","abundance":5.35,"rank":5514,"name":"Sh2d4a","annotation":"SH2 domain-containing protein 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation (By similarity). May play a role in T-cell development and function."},{"id":"ENSMUSP00000009875","abundance":5.35,"rank":5515,"name":"Kcnd1","annotation":"Potassium voltage-gated channel subfamily D member 1; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in the heart and I(Sa) current in neurons. Channel properties are modulated by subunit assembly; Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.1/KCND1 sub-subfamily."},{"id":"ENSMUSP00000048198","abundance":5.35,"rank":5516,"name":"Zdhhc5","annotation":"Palmitoyltransferase ZDHHC5; Palmitoyl acyltransferase for the G-protein coupled receptor SSTR5 and for FLOT2."},{"id":"ENSMUSP00000074621","abundance":5.35,"rank":5517,"name":"Smtn","annotation":"Smoothelin; Structural protein of the cytoskeleton."},{"id":"ENSMUSP00000130490","abundance":5.35,"rank":5518,"name":"Sult2a4","annotation":"Sulfotransferase; Belongs to the sulfotransferase 1 family."},{"id":"ENSMUSP00000051333","abundance":5.35,"rank":5519,"name":"Acot10","annotation":"Acyl-coenzyme A thioesterase 10, mitochondrial; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs."},{"id":"ENSMUSP00000028225","abundance":5.34,"rank":5520,"name":"Psmd5","annotation":"26S proteasome non-ATPase regulatory subunit 5; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD5:PSMC2:PSMC1:PSMD2 module which probably assembles with a PSMD10:PSMC4:PSMC5:PAAF1 module followed by dissociation of PSMD5 (By similarity)."},{"id":"ENSMUSP00000027125","abundance":5.34,"rank":5521,"name":"Coq10b","annotation":"Coenzyme Q-binding protein COQ10 homolog B, mitochondrial; Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity); Belongs to the COQ10 family."},{"id":"ENSMUSP00000157515","abundance":5.34,"rank":5522,"name":"Gal","annotation":"Galanin message-associated peptide; Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion; Belongs to the galanin family."},{"id":"ENSMUSP00000105486","abundance":5.34,"rank":5523,"name":"Eml1","annotation":"Echinoderm microtubule-associated protein-like 1; Modulates the assembly and organization of the microtubule cytoskeleton, and probably plays a role in regulating the orientation of the mitotic spindle and the orientation of the plane of cell division. Required for normal proliferation of neuronal progenitor cells in the developing brain and for normal brain development. Does not affect neuron migration per se; Belongs to the WD repeat EMAP family."},{"id":"ENSMUSP00000000304","abundance":5.34,"rank":5524,"name":"Hddc2","annotation":"HD domain-containing protein 2; Belongs to the HDDC2 family."},{"id":"ENSMUSP00000078181","abundance":5.34,"rank":5525,"name":"Stfa2l1","annotation":"Stefin-2; This is an intracellular thiol proteinase inhibitor."},{"id":"ENSMUSP00000070279","abundance":5.34,"rank":5526,"name":"Ddx55","annotation":"ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase."},{"id":"ENSMUSP00000067028","abundance":5.33,"rank":5527,"name":"Ankrd33","annotation":"Photoreceptor ankyrin repeat protein; [Isoform 1]: Acts as a transcriptional repressor for CRX- activated photoreceptor gene regulation."},{"id":"ENSMUSP00000099466","abundance":5.33,"rank":5528,"name":"Lpo","annotation":"Lactoperoxidase."},{"id":"ENSMUSP00000045709","abundance":5.33,"rank":5529,"name":"Pln","annotation":"Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation; Belongs to the phospholamban family."},{"id":"ENSMUSP00000099581","abundance":5.33,"rank":5530,"name":"Cela3b","annotation":"Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily."},{"id":"ENSMUSP00000024885","abundance":5.33,"rank":5531,"name":"Cebpz","annotation":"CCAAT/enhancer-binding protein zeta; Stimulates transcription from the HSP70 promoter; Belongs to the CBF/MAK21 family."},{"id":"ENSMUSP00000106460","abundance":5.33,"rank":5532,"name":"Mafk","annotation":"Transcription factor MafK; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (By similarity)."},{"id":"ENSMUSP00000125638","abundance":5.33,"rank":5533,"name":"Cnot11","annotation":"CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function (By similarity)."},{"id":"ENSMUSP00000017458","abundance":5.33,"rank":5534,"name":"Mpp2","annotation":"MAGUK p55 subfamily member 2; Postsynaptic MAGUK scaffold protein that links CADM1 cell adhesion molecules to core components of the postsynaptic density (By similarity). In CA1 pyramidal neurons, required for synaptic KCNN2- containing channel function and long-term potentiation expression. Seems to negatively regulate SRC function in epithelial cells (By similarity)."},{"id":"ENSMUSP00000022642","abundance":5.32,"rank":5535,"name":"Adam28","annotation":"Disintegrin and metalloproteinase domain-containing protein 28; May play a role in organogenesis and organ-specific functions such as thymic T-cell development."},{"id":"ENSMUSP00000047202","abundance":5.32,"rank":5536,"name":"Ppp1r11","annotation":"E3 ubiquitin-protein ligase PPP1R11; Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1 (By similarity)."},{"id":"ENSMUSP00000020024","abundance":5.32,"rank":5537,"name":"Fabp7","annotation":"Fatty acid-binding protein, brain; B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family."},{"id":"ENSMUSP00000047683","abundance":5.32,"rank":5538,"name":"Kdm2a","annotation":"Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the c [...] "},{"id":"ENSMUSP00000039537","abundance":5.32,"rank":5539,"name":"Nudt15","annotation":"Nucleotide triphosphate diphosphatase NUDT15; May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP. Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (By similarity). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms  [...] "},{"id":"ENSMUSP00000114843","abundance":5.32,"rank":5540,"name":"Syvn1","annotation":"E3 ubiquitin-protein ligase synoviolin; Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Sequesters p53/TP53 in [...] "},{"id":"ENSMUSP00000097777","abundance":5.31,"rank":5541,"name":"Dip2b","annotation":"Disco-interacting protein 2 homolog B."},{"id":"ENSMUSP00000033427","abundance":5.3,"rank":5542,"name":"Sash3","annotation":"SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes."},{"id":"ENSMUSP00000034087","abundance":5.3,"rank":5543,"name":"Snx20","annotation":"Sorting nexin-20; May play a role in cellular vesicle trafficking. Has been proposed to function as a sorting protein that targets SELPLG into endosomes, but has no effect on SELPLG internalization from the cell surface, nor on SELPLG-mediated cell-cell adhesion."},{"id":"ENSMUSP00000098829","abundance":5.3,"rank":5544,"name":"Reg3a","annotation":"Regenerating islet-derived protein 3-alpha 16.5 kDa form; Bactericidal C-type lectin (By similarity). Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway."},{"id":"ENSMUSP00000058617","abundance":5.3,"rank":5545,"name":"Sprr1b","annotation":"Cornifin-B; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane; Belongs to the cornifin (SPRR) family."},{"id":"ENSMUSP00000058618","abundance":5.3,"rank":5546,"name":"Bod1l","annotation":"Biorientation of chromosomes in cell division protein 1-like 1; Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2- dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM. Does not regulate spindle orientation."},{"id":"ENSMUSP00000120531","abundance":5.3,"rank":5547,"name":"Tcirg1","annotation":"V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase."},{"id":"ENSMUSP00000068258","abundance":5.3,"rank":5548,"name":"Bcl11b","annotation":"B-cell lymphoma/leukemia 11B; Key regulator of both differentiation and survival of T- lymphocytes during thymocyte development in mammals. Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes. Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. Repress tr [...] "},{"id":"ENSMUSP00000025279","abundance":5.29,"rank":5549,"name":"Npc1","annotation":"NPC intracellular cholesterol transporter 1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket (By similarity). May play a role in vesicular trafficking in glia, a process that may be crucial for main [...] "},{"id":"ENSMUSP00000078392","abundance":5.29,"rank":5550,"name":"Fam57b","annotation":"Ceramide synthase; Involved in ceramide synthesis. In vitro, isoform 3 stimulates the production of C16-, C18- and C20-ceramides, isoform 1 slightly increases the levels of C18- and C20-ceramides, while isoform 2 exhibits only minimal activity. May interfere with adipogenesis by stimulating ceramide synthesis."},{"id":"ENSMUSP00000002013","abundance":5.28,"rank":5551,"name":"Spa17","annotation":"Sperm surface protein Sp17; Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)."},{"id":"ENSMUSP00000002737","abundance":5.28,"rank":5552,"name":"Alkbh7","annotation":"Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; May function as protein hydroxylase; can catalyze auto- hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate. Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death. ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage. Does  [...] "},{"id":"ENSMUSP00000126351","abundance":5.28,"rank":5553,"name":"Gm21319","annotation":"Predicted gene, 21319; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits."},{"id":"ENSMUSP00000025867","abundance":5.28,"rank":5554,"name":"Rela","annotation":"Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kap [...] "},{"id":"ENSMUSP00000124290","abundance":5.28,"rank":5555,"name":"Kctd17","annotation":"Potassium channel tetramerisation domain-containing 17."},{"id":"ENSMUSP00000024967","abundance":5.27,"rank":5556,"name":"Msh2","annotation":"DNA mismatch repair protein Msh2; Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a t [...] "},{"id":"ENSMUSP00000026827","abundance":5.27,"rank":5557,"name":"Mettl26","annotation":"Methyltransferase-like 26; Belongs to the UPF0585 family."},{"id":"ENSMUSP00000109493","abundance":5.27,"rank":5558,"name":"Kcnj15","annotation":"ATP-sensitive inward rectifier potassium channel 15; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium."},{"id":"ENSMUSP00000041702","abundance":5.27,"rank":5559,"name":"Kcna2","annotation":"Potassium voltage-gated channel subfamily A member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and the central nervous system, but also in the cardiovascular system. Prevents aberrant action potential firing and regulates neuronal output. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form funct [...] "},{"id":"ENSMUSP00000063590","abundance":5.27,"rank":5560,"name":"Nup107","annotation":"Nuclear pore complex protein Nup107; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. Required for the assembly of peripheral proteins into the NPC. May anchor NUP62 to the NPC. Involved in nephrogenesis."},{"id":"ENSMUSP00000142481","abundance":5.26,"rank":5561,"name":"Sbno1","annotation":"Protein strawberry notch homolog 1; Belongs to the SBNO family."},{"id":"ENSMUSP00000129592","abundance":5.26,"rank":5562,"name":"Ptprj","annotation":"Receptor-type tyrosine-protein phosphatase eta; Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. May be involved in the mechanism of contact inhibition of cell growth. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell pro [...] "},{"id":"ENSMUSP00000082154","abundance":5.25,"rank":5563,"name":"Arnt2","annotation":"Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis, postnatal brain growth, and visual and renal function. Specifically recognizes the xenobiotic response element (XRE)."},{"id":"ENSMUSP00000038615","abundance":5.25,"rank":5564,"name":"Txlng","annotation":"Gamma-taxilin; May be involved in intracellular vesicle traffic (By similarity). Inhibits ATF4-mediated transcription, possibly by dimerizing with ATF4 to form inactive dimers that cannot bind DNA. May be involved in regulating bone mass density through an ATF4-dependent pathway. May be involved in cell cycle progression."},{"id":"ENSMUSP00000036696","abundance":5.25,"rank":5565,"name":"Gmds","annotation":"GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily."},{"id":"ENSMUSP00000106017","abundance":5.24,"rank":5566,"name":"Ncaph","annotation":"Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. Belongs to the CND2 (condensin s [...] "},{"id":"ENSMUSP00000065228","abundance":5.24,"rank":5567,"name":"Gtf2h2","annotation":"General transcription factor IIH subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] "},{"id":"ENSMUSP00000051895","abundance":5.24,"rank":5568,"name":"Gp5","annotation":"Platelet glycoprotein V; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis (By similarity)."},{"id":"ENSMUSP00000064220","abundance":5.24,"rank":5569,"name":"Dmrtb1","annotation":"Doublesex- and mab-3-related transcription factor B1; Belongs to the DMRT family."},{"id":"ENSMUSP00000039776","abundance":5.24,"rank":5570,"name":"Pold1","annotation":"DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] "},{"id":"ENSMUSP00000151921","abundance":5.24,"rank":5571,"name":"Grik2","annotation":"Glutamate receptor ionotropic, kainate 2; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. M [...] "},{"id":"ENSMUSP00000043245","abundance":5.23,"rank":5572,"name":"Ubac2","annotation":"Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets (By similarity). In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin- mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6."},{"id":"ENSMUSP00000043575","abundance":5.23,"rank":5573,"name":"Gtpbp1","annotation":"GTP-binding protein 1; Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity)."},{"id":"ENSMUSP00000031186","abundance":5.23,"rank":5574,"name":"Ugt2b35","annotation":"UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000131976","abundance":5.23,"rank":5575,"name":"Slc29a1","annotation":"Equilibrative nucleoside transporter 1; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). It is sensitive (ES) to low concentrations of the inhibitor nitrobenzylmercaptopurine riboside (NBMPR) and is sodium-independent. It has a higher affinity for adenosine. Resistant to dipyridamole and dilazep inhibition (anticancer chemotherapeutics drugs)."},{"id":"ENSMUSP00000048229","abundance":5.22,"rank":5576,"name":"Lyplal1","annotation":"Lysophospholipase-like protein 1; Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (By similarity)."},{"id":"ENSMUSP00000071989","abundance":5.22,"rank":5577,"name":"Ccnb1","annotation":"G2/mitotic-specific cyclin-B1; Essential for the control of the cell cycle at the G2/M (mitosis) transition; Belongs to the cyclin family. Cyclin AB subfamily."},{"id":"ENSMUSP00000091428","abundance":5.21,"rank":5578,"name":"Tepsin","annotation":"AP-4 complex accessory subunit Tepsin; Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network."},{"id":"ENSMUSP00000073244","abundance":5.21,"rank":5579,"name":"Cytl1","annotation":"Cytokine-like protein C17."},{"id":"ENSMUSP00000115695","abundance":5.21,"rank":5580,"name":"Srrm3","annotation":"Serine/arginine repetitive matrix protein 3; May play a role in regulating breast cancer cell invasiveness. May be involved in RYBP-mediated breast cancer progression; Belongs to the CWC21 family."},{"id":"ENSMUSP00000043588","abundance":5.21,"rank":5581,"name":"Crygs","annotation":"Gamma-crystallin S; Crystallins are the dominant structural components of the vertebrate eye lens."},{"id":"ENSMUSP00000101315","abundance":5.2,"rank":5582,"name":"Pik3cd","annotation":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell recepto [...] "},{"id":"ENSMUSP00000028696","abundance":5.2,"rank":5583,"name":"Ddb2","annotation":"DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (al [...] "},{"id":"ENSMUSP00000002259","abundance":5.2,"rank":5584,"name":"Clgn","annotation":"Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions. Belongs to the calreticulin family."},{"id":"ENSMUSP00000106443","abundance":5.2,"rank":5585,"name":"Hdac9","annotation":"Histone deacetylase 9; Devoided of intrinsic deacetylase activity, promotes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) by recruiting HDAC1 and HDAC3. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Represses MEF2-dependent transcription, inhibits skeletal myogenesis and may be involved in heart development. Protects neurons from apoptosis, both by inhibiting JUN phosphorylation by MAPK10 and by repressing JUN [...] "},{"id":"ENSMUSP00000074416","abundance":5.2,"rank":5586,"name":"Bcas3","annotation":"Breast carcinoma-amplified sequence 3 homolog; Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin (By similarity). Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation. Belongs to the BCAS3 family."},{"id":"ENSMUSP00000023282","abundance":5.19,"rank":5587,"name":"Miox","annotation":"Inositol oxygenase."},{"id":"ENSMUSP00000044292","abundance":5.19,"rank":5588,"name":"Nubpl","annotation":"Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (By similarity)."},{"id":"ENSMUSP00000129264","abundance":5.19,"rank":5589,"name":"Cyp4f15","annotation":"Cytochrome P450, family 4, subfamily f, polypeptide 15; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000076435","abundance":5.18,"rank":5590,"name":"Tpte","annotation":"Transmembrane phosphatase with tensin homology."},{"id":"ENSMUSP00000116205","abundance":5.17,"rank":5591,"name":"Stag1","annotation":"Cohesin subunit SA-1; Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity); Belongs to the SCC3 family."},{"id":"ENSMUSP00000066399","abundance":5.17,"rank":5592,"name":"Sp100","annotation":"Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regul [...] "},{"id":"ENSMUSP00000078384","abundance":5.17,"rank":5593,"name":"Ttyh1","annotation":"Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity); Belongs to the tweety family."},{"id":"ENSMUSP00000140745","abundance":5.16,"rank":5594,"name":"Csta2","annotation":"Cystatin A family member 2; Belongs to the cystatin family."},{"id":"ENSMUSP00000099502","abundance":5.16,"rank":5595,"name":"Nle1","annotation":"Notchless protein homolog 1; Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival."},{"id":"ENSMUSP00000099383","abundance":5.15,"rank":5596,"name":"Acot8","annotation":"Acyl-coenzyme A thioesterase 8; Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 8/ACOT8 display no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyz [...] "},{"id":"ENSMUSP00000025759","abundance":5.15,"rank":5597,"name":"Eif1ad","annotation":"Probable RNA-binding protein EIF1AD; Plays a role into cellular response to oxidative stress. Decreases cell proliferation (By similarity)."},{"id":"ENSMUSP00000053897","abundance":5.15,"rank":5598,"name":"Erbb2","annotation":"Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and  [...] "},{"id":"ENSMUSP00000071289","abundance":5.15,"rank":5599,"name":"Nf1","annotation":"Neurofibromin; Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity."},{"id":"ENSMUSP00000034473","abundance":5.15,"rank":5600,"name":"Spata19","annotation":"Spermatogenesis-associated protein 19, mitochondrial; May have a role in spermiogenesis."},{"id":"ENSMUSP00000007993","abundance":5.14,"rank":5601,"name":"Rbm28","annotation":"RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes."},{"id":"ENSMUSP00000101080","abundance":5.14,"rank":5602,"name":"Ctnna3","annotation":"Catenin alpha-3; May be involved in formation of stretch-resistant cell-cell adhesion complexes."},{"id":"ENSMUSP00000056383","abundance":5.13,"rank":5603,"name":"Atat1","annotation":"Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] "},{"id":"ENSMUSP00000081541","abundance":5.12,"rank":5604,"name":"Abraxas2","annotation":"BRISC complex subunit Abraxas 2; Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates. May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (By similarity). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys- 63'-linked ubiquitination of target proteins. Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubi [...] "},{"id":"ENSMUSP00000003759","abundance":5.12,"rank":5605,"name":"Ciao1","annotation":"Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (By similarity). As a CIA complex component, interacts specifically with CIAO2A or CIAO2B and MMS19 to assist different branches of iron-sulfur protein assembly, depending of its interactors. The complex CIAO1:CIAO2B:MMS19 binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. CIAO1:CIAO2A specifically matures AC [...] "},{"id":"ENSMUSP00000095349","abundance":5.12,"rank":5606,"name":"Tmem88b","annotation":"Transmembrane protein 88B."},{"id":"ENSMUSP00000034754","abundance":5.11,"rank":5607,"name":"Bnip2","annotation":"BCL2/adenovirus E1B 19 kDa protein-interacting protein 2; Implicated in the suppression of cell death. Interacts with the BCL-2 and adenovirus E1B 19 kDa proteins (By similarity)."},{"id":"ENSMUSP00000047254","abundance":5.11,"rank":5608,"name":"Xylb","annotation":"Xylulose kinase; Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis."},{"id":"ENSMUSP00000002678","abundance":5.11,"rank":5609,"name":"Tgfb1","annotation":"Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration. Activation into mature form follows different  [...] "},{"id":"ENSMUSP00000114211","abundance":5.11,"rank":5610,"name":"Dcaf11","annotation":"DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex."},{"id":"ENSMUSP00000114132","abundance":5.1,"rank":5611,"name":"Snrk","annotation":"SNF-related serine/threonine-protein kinase; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis (By similarity)."},{"id":"ENSMUSP00000043580","abundance":5.1,"rank":5612,"name":"Alg2","annotation":"Alpha-1,3/1,6-mannosyltransferase ALG2; Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate."},{"id":"ENSMUSP00000120911","abundance":5.1,"rank":5613,"name":"Tbl3","annotation":"Transducin beta-like protein 3."},{"id":"ENSMUSP00000062865","abundance":5.1,"rank":5614,"name":"Oc90","annotation":"Otoconin-90; Major protein of the otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Together with OTOL1, acts as a scaffold for otoconia biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OTOL1, modulates calcite crystal morphology and growth kinetics. It is unlikely that this protein has phospholipase A2 activity."},{"id":"ENSMUSP00000136382","abundance":5.1,"rank":5615,"name":"Kcnj16","annotation":"Inward rectifier potassium channel 16; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolater [...] "},{"id":"ENSMUSP00000104976","abundance":5.09,"rank":5616,"name":"Sys1","annotation":"Protein SYS1 homolog; Involved in protein trafficking. May serve as a receptor for ARFRP1 (By similarity)."},{"id":"ENSMUSP00000132983","abundance":5.09,"rank":5617,"name":"Zfp54","annotation":"Zinc finger protein 54; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000078972","abundance":5.09,"rank":5618,"name":"Slc4a2","annotation":"Anion exchange protein 2; Plasma membrane anion exchange protein of wide distribution; Belongs to the anion exchanger (TC 2.A.31) family."},{"id":"ENSMUSP00000128401","abundance":5.08,"rank":5619,"name":"Tap1","annotation":"Antigen peptide transporter 1; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily."},{"id":"ENSMUSP00000118107","abundance":5.08,"rank":5620,"name":"Sbf1","annotation":"Myotubularin-related protein 5; Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location. May function as a guanine nucleotide exchange factor (GEF) activating RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts."},{"id":"ENSMUSP00000074775","abundance":5.08,"rank":5621,"name":"Hdhd5","annotation":"Haloacid dehalogenase-like hydrolase domain-containing 5; Belongs to the HAD-like hydrolase superfamily."},{"id":"ENSMUSP00000156031","abundance":5.08,"rank":5622,"name":"Cd80","annotation":"T-lymphocyte activation antigen CD80; Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor."},{"id":"ENSMUSP00000070113","abundance":5.08,"rank":5623,"name":"Nrgn","annotation":"NEUG(55-78); Regulates the affinity of calmodulin for calcium. Involved in synaptic plasticity and spatial learning. Belongs to the neurogranin family."},{"id":"ENSMUSP00000039013","abundance":5.07,"rank":5624,"name":"Rragb","annotation":"Ras-related GTP-binding protein B; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. Belongs to the GTR/RAG GTP-binding protein family."},{"id":"ENSMUSP00000033380","abundance":5.07,"rank":5625,"name":"Cdk16","annotation":"Cyclin-dependent kinase 16; Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Can phosphorylate CCNY at 'Ser-336' (in vitro) (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."},{"id":"ENSMUSP00000001595","abundance":5.07,"rank":5626,"name":"Fkbp10","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP10; PPIases accelerate the folding of proteins during protein synthesis."},{"id":"ENSMUSP00000055037","abundance":5.07,"rank":5627,"name":"Skor1","annotation":"SKI family transcriptional corepressor 1; Inhibits BMP signaling (By similarity). Acts as a transcriptional corepressor of LBX1."},{"id":"ENSMUSP00000036631","abundance":5.07,"rank":5628,"name":"Cilp","annotation":"Cartilage intermediate layer protein 1 C1; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity)."},{"id":"ENSMUSP00000029316","abundance":5.07,"rank":5629,"name":"Exosc8","annotation":"Exosome complex component RRP43; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] "},{"id":"ENSMUSP00000139638","abundance":5.06,"rank":5630,"name":"Pign","annotation":"GPI ethanolamine phosphate transferase 1; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. May act as suppressor of replication stress and chromosome missegregation."},{"id":"ENSMUSP00000142053","abundance":5.05,"rank":5631,"name":"Lamb3","annotation":"Laminin subunit beta-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."},{"id":"ENSMUSP00000084450","abundance":5.05,"rank":5632,"name":"Gnl1","annotation":"Guanine nucleotide-binding protein-like 1; Possible regulatory or functional link with the histocompatibility cluster."},{"id":"ENSMUSP00000074387","abundance":5.05,"rank":5633,"name":"Preb","annotation":"Prolactin regulatory element-binding protein; Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER."},{"id":"ENSMUSP00000046320","abundance":5.05,"rank":5634,"name":"Ss18","annotation":"Protein SSXT; Appears to function synergistically with RBM14 as a transcriptional coactivator. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner; Belongs to the SS18 family."},{"id":"ENSMUSP00000102236","abundance":5.05,"rank":5635,"name":"5330417C22Rik","annotation":"UPF0577 protein KIAA1324; May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway."},{"id":"ENSMUSP00000027502","abundance":5.04,"rank":5636,"name":"Atg4b","annotation":"Cysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity)."},{"id":"ENSMUSP00000026891","abundance":5.04,"rank":5637,"name":"Exosc7","annotation":"Exosome complex exonuclease RRP42; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cy [...] "},{"id":"ENSMUSP00000127716","abundance":5.04,"rank":5638,"name":"Pid1","annotation":"PTB-containing, cubilin and LRP1-interacting protein; Increases proliferation of preadipocytes without affecting adipocytic differentiation."},{"id":"ENSMUSP00000032419","abundance":5.04,"rank":5639,"name":"Cmas","annotation":"N-acylneuraminate cytidylyltransferase; Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D- glycero-D-galacto-nononic acid (KDN)."},{"id":"ENSMUSP00000072848","abundance":5.03,"rank":5640,"name":"Ppp4r1","annotation":"Serine/threonine-protein phosphatase 4 regulatory subunit 1; Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3 (By similarity)."},{"id":"ENSMUSP00000017981","abundance":5.03,"rank":5641,"name":"Nkiras2","annotation":"NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity); Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily."},{"id":"ENSMUSP00000029240","abundance":5.03,"rank":5642,"name":"Slc2a2","annotation":"Solute carrier family 2, facilitated glucose transporter member 2; Facilitative hexose transporter that mediates the transport of glucose and fructose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate."},{"id":"ENSMUSP00000078459","abundance":5.03,"rank":5643,"name":"Ube2s","annotation":"Ubiquitin-conjugating enzyme E2 S; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiqui [...] "},{"id":"ENSMUSP00000128090","abundance":5.03,"rank":5644,"name":"Tgm1","annotation":"Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity)."},{"id":"ENSMUSP00000141380","abundance":5.03,"rank":5645,"name":"Rgs7","annotation":"Regulator of G-protein signaling 7; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling."},{"id":"ENSMUSP00000104207","abundance":5.03,"rank":5646,"name":"Zfp444","annotation":"Zinc finger protein 444."},{"id":"ENSMUSP00000080419","abundance":5.02,"rank":5647,"name":"Ezh2","annotation":"Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. Compared to EZH1-containing complexes, it is more abun [...] "},{"id":"ENSMUSP00000025062","abundance":5.02,"rank":5648,"name":"Clps","annotation":"Colipase; Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase."},{"id":"ENSMUSP00000039322","abundance":5.02,"rank":5649,"name":"Washc4","annotation":"WASH complex subunit 4; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes seems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in regulation of the fission of tubules that serve as transport intermediates during endosome sorting."},{"id":"ENSMUSP00000056754","abundance":5.02,"rank":5650,"name":"Kif1b","annotation":"Kinesin-like protein KIF1B; Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility."},{"id":"ENSMUSP00000039709","abundance":5.02,"rank":5651,"name":"Pcm1","annotation":"Pericentriolar material 1 protein; Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (By similarity). Required to anchor microtubules to the centrosome (By similarity). Involved in the biogenesis of cilia (By similarity)."},{"id":"ENSMUSP00000112937","abundance":5.02,"rank":5652,"name":"Vps8","annotation":"Vacuolar protein sorting-associated protein 8 homolog; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpo [...] "},{"id":"ENSMUSP00000028995","abundance":5.02,"rank":5653,"name":"Fam210b","annotation":"Protein FAM210B, mitochondrial; Plays a role in erythroid differentiation. Involved in cell proliferation and tumor cell growth suppression. Involved in the metabolic reprogramming of cancer cells in a PDK4-dependent manner. Belongs to the FAM210 family."},{"id":"ENSMUSP00000109989","abundance":5.01,"rank":5654,"name":"Ndor1","annotation":"NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family."},{"id":"ENSMUSP00000138676","abundance":5.01,"rank":5655,"name":"Pdf","annotation":"Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family."},{"id":"ENSMUSP00000025093","abundance":5.01,"rank":5656,"name":"Thumpd2","annotation":"THUMP domain-containing protein 2; Belongs to the methyltransferase superfamily."},{"id":"ENSMUSP00000110274","abundance":5.01,"rank":5657,"name":"Etl4","annotation":"Sickle tail protein; Required for normal development of intervertebral disks."},{"id":"ENSMUSP00000032958","abundance":5.01,"rank":5658,"name":"Ucp3","annotation":"Mitochondrial uncoupling protein 3; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000039908","abundance":5.01,"rank":5659,"name":"H2-M10.6","annotation":"Major histocompatibility complex class Ib M10.8; Belongs to the MHC class I family."},{"id":"ENSMUSP00000120966","abundance":5,"rank":5660,"name":"Cmc2","annotation":"COX assembly mitochondrial protein 2 homolog; May be involved in cytochrome c oxidase biogenesis. Belongs to the CMC family."},{"id":"ENSMUSP00000132450","abundance":5,"rank":5661,"name":"Atxn10","annotation":"Ataxin-10; Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis."},{"id":"ENSMUSP00000042987","abundance":5,"rank":5662,"name":"Rps6ka5","annotation":"Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes (By similarity). Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA tra [...] "},{"id":"ENSMUSP00000004732","abundance":5,"rank":5663,"name":"Lim2","annotation":"Lens fiber membrane intrinsic protein; Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis; Belongs to the PMP-22/EMP/MP20 family."},{"id":"ENSMUSP00000133478","abundance":5,"rank":5664,"name":"Baz1a","annotation":"Bromodomain adjacent to zinc finger domain protein 1A; Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S pha [...] "},{"id":"ENSMUSP00000021921","abundance":5,"rank":5665,"name":"Ptch1","annotation":"Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis."},{"id":"ENSMUSP00000109720","abundance":5,"rank":5666,"name":"Klf7","annotation":"Krueppel-like factor 7; Transcriptional factor. Plays a critical role in neuronal morphogenesis. Represses the corneal epithelium differentiation (By similarity). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells. Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000020411","abundance":5,"rank":5667,"name":"Osbpl5","annotation":"Oxysterol-binding protein-related protein 5; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol."},{"id":"ENSMUSP00000117231","abundance":4.99,"rank":5668,"name":"Hars2","annotation":"Histidine--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP)."},{"id":"ENSMUSP00000147767","abundance":4.99,"rank":5669,"name":"Casp3","annotation":"Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytok [...] "},{"id":"ENSMUSP00000001155","abundance":4.99,"rank":5670,"name":"Araf","annotation":"Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity)."},{"id":"ENSMUSP00000155364","abundance":4.99,"rank":5671,"name":"Rbfox1","annotation":"RNA binding protein fox-1 homolog 1; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis."},{"id":"ENSMUSP00000095228","abundance":4.99,"rank":5672,"name":"Pam","annotation":"Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; Bifunctional enzyme that catalyzes the post-translational modification of inactive peptidylglycine precursors to the corresponding bioactive alpha-amidated peptides, a terminal modification in biosynthesis of many neural and endocrine peptides (By similarity). Alpha-amidation involves two sequential reactions, both of which are catalyzed by separate catalytic domains of the enzyme. The first step, catalyzed by peptidyl alpha-hydroxylating monoxygenase (PHM) domain, is the copper-, ascorbate-, and O2- dependent stereospecific hydroxyl [...] "},{"id":"ENSMUSP00000026917","abundance":4.98,"rank":5673,"name":"Nrp1","annotation":"Neuropilin-1; Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system (By similarity). Mediates the chemorepulsant activity of semaphorins. Binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB (By similarity). Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulates VEGF-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron  [...] "},{"id":"ENSMUSP00000023489","abundance":4.98,"rank":5674,"name":"Fyttd1","annotation":"UAP56-interacting factor; Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4 (By similarity); Belongs to the UIF family."},{"id":"ENSMUSP00000130925","abundance":4.98,"rank":5675,"name":"Dvl3","annotation":"Segment polarity protein dishevelled homolog DVL-3; Involved in the signal transduction pathway mediated by multiple Wnt genes; Belongs to the DSH family."},{"id":"ENSMUSP00000023036","abundance":4.98,"rank":5676,"name":"Rbx1","annotation":"E3 ubiquitin-protein ligase RBX1, N-terminally processed; E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). The functional spec [...] "},{"id":"ENSMUSP00000073236","abundance":4.97,"rank":5677,"name":"H2-M10.3","annotation":"Major histocompatibility complex class Ib M10.3; Belongs to the MHC class I family."},{"id":"ENSMUSP00000114273","abundance":4.97,"rank":5678,"name":"Enpp1","annotation":"Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form; Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels. PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals. Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate [...] "},{"id":"ENSMUSP00000029999","abundance":4.97,"rank":5679,"name":"Polr1e","annotation":"DNA-directed RNA polymerase I subunit RPA49; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF."},{"id":"ENSMUSP00000030738","abundance":4.96,"rank":5680,"name":"Utp11","annotation":"Probable U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA."},{"id":"ENSMUSP00000140325","abundance":4.96,"rank":5681,"name":"Anapc13","annotation":"Anaphase-promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC13 family."},{"id":"ENSMUSP00000005611","abundance":4.96,"rank":5682,"name":"Myl10","annotation":"Myosin regulatory light chain 10."},{"id":"ENSMUSP00000004587","abundance":4.96,"rank":5683,"name":"Clec11a","annotation":"C-type lectin domain family 11 member A; Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone."},{"id":"ENSMUSP00000147233","abundance":4.95,"rank":5684,"name":"Gm44973","annotation":"Predicted gene 44973."},{"id":"ENSMUSP00000099991","abundance":4.95,"rank":5685,"name":"Pdpk1","annotation":"3-phosphoinositide-dependent protein kinase 1; Serine/threonine kinase which acts as a master kinase, phosphorylating and activating a subgroup of the AGC family of protein kinases. Its targets include: protein kinase B (PKB/AKT1, PKB/AKT2, PKB/AKT3), p70 ribosomal protein S6 kinase (RPS6KB1), p90 ribosomal protein S6 kinase (RPS6KA1, RPS6KA2 and RPS6KA3), cyclic AMP-dependent protein kinase (PRKACA), protein kinase C (PRKCD and PRKCZ), serum and glucocorticoid-inducible kinase (SGK1, SGK2 and SGK3), p21-activated kinase-1 (PAK1), protein kinase PKN (PKN1 and PKN2). Plays a central rol [...] "},{"id":"ENSMUSP00000037971","abundance":4.95,"rank":5686,"name":"Zfp91","annotation":"E3 ubiquitin-protein ligase ZFP91; Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF- kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000035083","abundance":4.95,"rank":5687,"name":"Stac","annotation":"SH3 and cysteine-rich domain-containing protein; Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows the rate of calcium-mediated inactivation of CACNA1C calcium channel activity."},{"id":"ENSMUSP00000107899","abundance":4.95,"rank":5688,"name":"Cltrn","annotation":"Collectrin; Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication."},{"id":"ENSMUSP00000032573","abundance":4.94,"rank":5689,"name":"Pglyrp1","annotation":"Peptidoglycan recognition protein 1; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria. Involved in innate immunity. May function in intracellular killing of bacteria. The soluble form triggers apoptosis in vitro. Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family."},{"id":"ENSMUSP00000087587","abundance":4.94,"rank":5690,"name":"Gbp5","annotation":"Guanylate-binding protein 5; As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, inflammasome activating agents. Hydrolyzes GTP, but in contrast to other family members, such as GBP1 and GBP2, does not produce GMP (By similarity)."},{"id":"ENSMUSP00000141182","abundance":4.94,"rank":5691,"name":"Wdhd1","annotation":"WD repeat and HMG-box DNA-binding protein 1; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication."},{"id":"ENSMUSP00000009617","abundance":4.94,"rank":5692,"name":"Kcnc4","annotation":"Potassium voltage-gated channel subfamily C member 4; This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (By similarity); Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily."},{"id":"ENSMUSP00000122402","abundance":4.94,"rank":5693,"name":"Abcc12","annotation":"Multidrug resistance-associated protein 9; Probable transporter; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily."},{"id":"ENSMUSP00000103381","abundance":4.93,"rank":5694,"name":"Hsd17b14","annotation":"Hydroxysteroid (17-beta) dehydrogenase 14."},{"id":"ENSMUSP00000042410","abundance":4.93,"rank":5695,"name":"Slc30a1","annotation":"Zinc transporter 1; May be involved in zinc transport out of the cell. Lethality of knockout early in gestation suggests a role of the protein in fetal zinc acquisition and retention; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily."},{"id":"ENSMUSP00000028963","abundance":4.93,"rank":5696,"name":"Tbc1d20","annotation":"TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude."},{"id":"ENSMUSP00000096809","abundance":4.93,"rank":5697,"name":"Defb25","annotation":"Beta-defensin 25; Has antibacterial activity; Belongs to the beta-defensin family."},{"id":"ENSMUSP00000035992","abundance":4.93,"rank":5698,"name":"Gga1","annotation":"ADP-ribosylation factor-binding protein GGA1; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface (By similarity). Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane. Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endo [...] "},{"id":"ENSMUSP00000092951","abundance":4.93,"rank":5699,"name":"Pawr","annotation":"PRKC apoptosis WT1 regulator protein; Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti- apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repress [...] "},{"id":"ENSMUSP00000004222","abundance":4.93,"rank":5700,"name":"Hira","annotation":"Protein HIRA; Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit."},{"id":"ENSMUSP00000148993","abundance":4.93,"rank":5701,"name":"Olfr577","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000039139","abundance":4.93,"rank":5702,"name":"Arhgap44","annotation":"Rho GTPase-activating protein 44; GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1. In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin- patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contract [...] "},{"id":"ENSMUSP00000035214","abundance":4.92,"rank":5703,"name":"Ip6k1","annotation":"Inositol hexakisphosphate kinase 1; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4."},{"id":"ENSMUSP00000125540","abundance":4.92,"rank":5704,"name":"Ubl5","annotation":"Ubiquitin-like protein 5."},{"id":"ENSMUSP00000034623","abundance":4.92,"rank":5705,"name":"Trappc4","annotation":"Trafficking protein particle complex subunit 4; May play a role in vesicular transport from endoplasmic reticulum to Golgi. May play a role in dendrite postsynaptic membrane trafficking; Belongs to the TRAPP small subunits family. TRAPPC4 subfamily."},{"id":"ENSMUSP00000107150","abundance":4.92,"rank":5706,"name":"Fmo4","annotation":"Dimethylaniline monooxygenase [N-oxide-forming] 4; This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides; Belongs to the FMO family."},{"id":"ENSMUSP00000129024","abundance":4.92,"rank":5707,"name":"Mapk6","annotation":"Mitogen-activated protein kinase 6; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle."},{"id":"ENSMUSP00000026254","abundance":4.92,"rank":5708,"name":"Gbf1","annotation":"Golgi-specific brefeldin A-resistance factor 1."},{"id":"ENSMUSP00000003501","abundance":4.92,"rank":5709,"name":"Elavl3","annotation":"ELAV-like protein 3; RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. Plays a role in the stabilization of GAP43 mRNA and in spatial learning."},{"id":"ENSMUSP00000097531","abundance":4.92,"rank":5710,"name":"Gm13697","annotation":"Predicted gene 13697."},{"id":"ENSMUSP00000136546","abundance":4.92,"rank":5711,"name":"Gm13693","annotation":"Predicted gene 13693."},{"id":"ENSMUSP00000137026","abundance":4.92,"rank":5712,"name":"Gm13698","annotation":"Predicted gene 13698."},{"id":"ENSMUSP00000137022","abundance":4.92,"rank":5713,"name":"Gm13696","annotation":"Predicted gene 13696."},{"id":"ENSMUSP00000097530","abundance":4.92,"rank":5714,"name":"Gm13691","annotation":"Predicted gene 13691."},{"id":"ENSMUSP00000135979","abundance":4.92,"rank":5715,"name":"Gm13694","annotation":"Predicted gene 13694."},{"id":"ENSMUSP00000097534","abundance":4.92,"rank":5716,"name":"Gm13695","annotation":"Predicted gene 13695."},{"id":"ENSMUSP00000004507","abundance":4.92,"rank":5717,"name":"Ddx56","annotation":"Probable ATP-dependent RNA helicase DDX56; May play a role in later stages of the processing of the pre- ribosomal particles leading to mature 60S ribosomal subunits. Has intrinsic ATPase activity (By similarity); Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily."},{"id":"ENSMUSP00000026498","abundance":4.91,"rank":5718,"name":"Crisp1","annotation":"Cysteine-rich secretory protein 1; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens."},{"id":"ENSMUSP00000039486","abundance":4.91,"rank":5719,"name":"Rnf126","annotation":"E3 ubiquitin-protein ligase RNF126; E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (By similarity). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome (By similarity). Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins  [...] "},{"id":"ENSMUSP00000023845","abundance":4.91,"rank":5720,"name":"H2-M10.2","annotation":"Histocompatibility 2, M region locus 10.2; Belongs to the MHC class I family."},{"id":"ENSMUSP00000036013","abundance":4.91,"rank":5721,"name":"Cdk13","annotation":"Cyclin-dependent kinase 13; Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis."},{"id":"ENSMUSP00000062753","abundance":4.91,"rank":5722,"name":"Irf2bp2","annotation":"Interferon regulatory factor 2-binding protein 2; Acts as a transcriptional corepressor in a IRF2-dependent manner, this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT- responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation (By similarity)."},{"id":"ENSMUSP00000034370","abundance":4.91,"rank":5723,"name":"Slc12a4","annotation":"Solute carrier family 12 member 4; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia; Belongs to the SLC12A transporter family."},{"id":"ENSMUSP00000041070","abundance":4.9,"rank":5724,"name":"Irf2bpl","annotation":"Probable E3 ubiquitin-protein ligase IRF2BPL; Probable E3 ubiquitin protein ligase involved in the proteasome-mediated ubiquitin-dependent degradation of target proteins. Through the degradation of CTNNB1, functions downstream of FOXF2 to negatively regulate the Wnt signaling pathway. Probably plays a role in the development of the central nervous system and in neuronal maintenance (By similarity). Also acts as a transcriptional regulator of genes controlling female reproductive function. May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promot [...] "},{"id":"ENSMUSP00000133204","abundance":4.9,"rank":5725,"name":"Pcid2","annotation":"PCI domain-containing protein 2; Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells (By similarity)."},{"id":"ENSMUSP00000025209","abundance":4.9,"rank":5726,"name":"Spata24","annotation":"Spermatogenesis-associated protein 24; Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box-containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis; Belongs to the SPATA24 family."},{"id":"ENSMUSP00000092702","abundance":4.9,"rank":5727,"name":"Acnat1","annotation":"Acyl-coenzyme A amino acid N-acyltransferase 1; Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine."},{"id":"ENSMUSP00000089462","abundance":4.9,"rank":5728,"name":"Mapk4","annotation":"Mitogen-activated protein kinase 4; Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily."},{"id":"ENSMUSP00000087500","abundance":4.89,"rank":5729,"name":"Tmem87a","annotation":"Transmembrane protein 87A; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN)."},{"id":"ENSMUSP00000031055","abundance":4.89,"rank":5730,"name":"Emilin1","annotation":"EMILIN-1; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity (By similarity). May have a function in placenta formation and initial organogenesis and a later role in interstitial connective tissue."},{"id":"ENSMUSP00000013759","abundance":4.89,"rank":5731,"name":"Fnbp4","annotation":"Formin-binding protein 4."},{"id":"ENSMUSP00000030879","abundance":4.89,"rank":5732,"name":"Clcn6","annotation":"Chloride transport protein 6; Chloride transport protein, initially identified as voltage- gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter."},{"id":"ENSMUSP00000099614","abundance":4.89,"rank":5733,"name":"Kif1c","annotation":"Kinesin-like protein KIF1C; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility (By similarity)."},{"id":"ENSMUSP00000123998","abundance":4.88,"rank":5734,"name":"Hmga2","annotation":"High mobility group protein HMGI-C; Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation."},{"id":"ENSMUSP00000021346","abundance":4.88,"rank":5735,"name":"Tshr","annotation":"Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily."},{"id":"ENSMUSP00000103658","abundance":4.88,"rank":5736,"name":"Ccne1","annotation":"G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition."},{"id":"ENSMUSP00000062556","abundance":4.88,"rank":5737,"name":"Scg2","annotation":"Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules."},{"id":"ENSMUSP00000015901","abundance":4.88,"rank":5738,"name":"Ppil4","annotation":"Peptidyl-prolyl cis-trans isomerase-like 4; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)."},{"id":"ENSMUSP00000107250","abundance":4.87,"rank":5739,"name":"Ppfibp1","annotation":"Liprin-beta-1; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity). Belongs to the liprin family. Liprin-beta subfamily."},{"id":"ENSMUSP00000137933","abundance":4.87,"rank":5740,"name":"Ssh2","annotation":"Protein phosphatase Slingshot homolog 2; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein."},{"id":"ENSMUSP00000024709","abundance":4.87,"rank":5741,"name":"Cd2ap","annotation":"CD2-associated protein; Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton (By similarity). In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation (By similarity). May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen- presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glo [...] "},{"id":"ENSMUSP00000014290","abundance":4.87,"rank":5742,"name":"Apbb1ip","annotation":"Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion (By similarity)."},{"id":"ENSMUSP00000034599","abundance":4.87,"rank":5743,"name":"Tmprss4","annotation":"Transmembrane protease serine 4; Probable protease. Seems to be capable of activating ENaC; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000033842","abundance":4.87,"rank":5744,"name":"Myom2","annotation":"Myomesin 2."},{"id":"ENSMUSP00000153044","abundance":4.87,"rank":5745,"name":"Zfp131","annotation":"Zinc finger protein 131; May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling (By similarity). Plays a role during development and organogenesis as well as in the function of the adult central nervous system."},{"id":"ENSMUSP00000046943","abundance":4.86,"rank":5746,"name":"Serpini2","annotation":"Serpin I2; Belongs to the serpin family."},{"id":"ENSMUSP00000096248","abundance":4.86,"rank":5747,"name":"Pias1","annotation":"E3 SUMO-protein ligase PIAS1; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. In vitro, binds A/T-rich DNA (By similarity). The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context. Sumoylates PML (at'Lys-65' and 'Lys-160') and PML-RAR  [...] "},{"id":"ENSMUSP00000097647","abundance":4.86,"rank":5748,"name":"Scn3a","annotation":"Sodium channel protein type 3 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, forms a sodium- selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. May contribute to the regulation of serotonin/5-hydroxytryptamine release by enterochromaffin cells. In pancreatic endocrine cells, required for both glucagon and glucose-induced insulin secretion."},{"id":"ENSMUSP00000110544","abundance":4.86,"rank":5749,"name":"Lyg1","annotation":"Lysozyme g-like protein 1."},{"id":"ENSMUSP00000064947","abundance":4.85,"rank":5750,"name":"Cwc22","annotation":"Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing as component of the spliceosome. Promotes exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. Belongs to the CWC22 family."},{"id":"ENSMUSP00000124505","abundance":4.85,"rank":5751,"name":"Stau2","annotation":"Double-stranded RNA-binding protein Staufen homolog 2; RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body (By similarity)."},{"id":"ENSMUSP00000090304","abundance":4.85,"rank":5752,"name":"Lama2","annotation":"Laminin subunit alpha-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."},{"id":"ENSMUSP00000001419","abundance":4.85,"rank":5753,"name":"Zmat2","annotation":"Zinc finger matrin-type protein 2; Involved in pre-mRNA splicing as a component of the spliceosome."},{"id":"ENSMUSP00000046046","abundance":4.84,"rank":5754,"name":"Efl1","annotation":"Elongation factor-like GTPase 1; Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits (By similarity); Belongs to the TRAFAC class transl [...] "},{"id":"ENSMUSP00000103943","abundance":4.84,"rank":5755,"name":"Virma","annotation":"Protein virilizer homolog; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs in the 3'-UTR near the stop codon: recruits the catalytic core components METTL3 and METTL14, thereby guiding m6A methylation at specific sites. Required for mRNA polyadenylation via its role in selective m6A methylation: m6A methylation of mRNAs in the 3'-UTR near the stop codon corr [...] "},{"id":"ENSMUSP00000048326","abundance":4.84,"rank":5756,"name":"Kcnk15","annotation":"Potassium channel subfamily K member."},{"id":"ENSMUSP00000055295","abundance":4.84,"rank":5757,"name":"Nhlrc3","annotation":"NHL repeat-containing protein 3."},{"id":"ENSMUSP00000055416","abundance":4.84,"rank":5758,"name":"Diras2","annotation":"GTP-binding protein Di-Ras2; Displays low GTPase activity and exists predominantly in the GTP-bound form; Belongs to the small GTPase superfamily. Di-Ras family."},{"id":"ENSMUSP00000150121","abundance":4.84,"rank":5759,"name":"Smco4","annotation":"Single-pass membrane and coiled-coil domain-containing protein 4."},{"id":"ENSMUSP00000099755","abundance":4.83,"rank":5760,"name":"Ptgfrn","annotation":"Prostaglandin F2 receptor negative regulator; Inhibits the binding of prostaglandin F2-alpha (PGF2-alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity). In myoblasts, associates with tetraspanins CD9 and CD81 to prevent myotube fusion during muscle regeneration."},{"id":"ENSMUSP00000049723","abundance":4.83,"rank":5761,"name":"Nek6","annotation":"Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase- anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, TRIP4, RPS6KB1 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence (By si [...] "},{"id":"ENSMUSP00000029371","abundance":4.83,"rank":5762,"name":"Smad9","annotation":"Mothers against decapentaplegic homolog 9; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor- regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation; Belongs to the dwarfin/SMAD family."},{"id":"ENSMUSP00000055110","abundance":4.83,"rank":5763,"name":"Aqp3","annotation":"Aquaporin-3; Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an [...] "},{"id":"ENSMUSP00000027688","abundance":4.83,"rank":5764,"name":"Rassf5","annotation":"Ras association domain-containing protein 5; Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in re [...] "},{"id":"ENSMUSP00000042785","abundance":4.83,"rank":5765,"name":"Ak5","annotation":"Adenylate kinase isoenzyme 5; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity."},{"id":"ENSMUSP00000032927","abundance":4.83,"rank":5766,"name":"Stard10","annotation":"START domain-containing protein 10; Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes (By similarity). May play metabolic roles in sperm maturation or fertilization."},{"id":"ENSMUSP00000111300","abundance":4.83,"rank":5767,"name":"Suv39h1","annotation":"Histone-lysine N-methyltransferase SUV39H1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] "},{"id":"ENSMUSP00000033765","abundance":4.82,"rank":5768,"name":"Avpr2","annotation":"Vasopressin V2 receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity)."},{"id":"ENSMUSP00000107210","abundance":4.82,"rank":5769,"name":"Afap1l2","annotation":"Actin filament-associated protein 1-like 2; May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation (By similarity)."},{"id":"ENSMUSP00000096129","abundance":4.82,"rank":5770,"name":"Cebpa","annotation":"CCAAT/enhancer-binding protein alpha; Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes. During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung. Necessary for [...] "},{"id":"ENSMUSP00000026129","abundance":4.82,"rank":5771,"name":"Pcyt2","annotation":"Ethanolamine-phosphate cytidylyltransferase; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP- ethanolamine (By similarity)."},{"id":"ENSMUSP00000030317","abundance":4.82,"rank":5772,"name":"Pdpn","annotation":"Podoplanin; Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation and pulmonary metastasis induced by PDPN. Mediates effects on cell migration and adhesion through its different partners. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and tr [...] "},{"id":"ENSMUSP00000034511","abundance":4.81,"rank":5773,"name":"Trim29","annotation":"Tripartite motif-containing protein 29; Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation."},{"id":"ENSMUSP00000119606","abundance":4.81,"rank":5774,"name":"Pank2","annotation":"Pantothenate kinase 2 (Hallervorden-Spatz syndrome)."},{"id":"ENSMUSP00000105833","abundance":4.81,"rank":5775,"name":"Esrrb","annotation":"Steroid hormone receptor ERR2; Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcriptional activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activ [...] "},{"id":"ENSMUSP00000020719","abundance":4.81,"rank":5776,"name":"2310033P09Rik","annotation":"Multiple myeloma tumor-associated protein 2 homolog."},{"id":"ENSMUSP00000021632","abundance":4.81,"rank":5777,"name":"Akr1c12","annotation":"Aldo-keto reductase family 1, member C12."},{"id":"ENSMUSP00000023057","abundance":4.8,"rank":5778,"name":"Nptxr","annotation":"Neuronal pentraxin receptor; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses."},{"id":"ENSMUSP00000022597","abundance":4.8,"rank":5779,"name":"Naa16","annotation":"N-alpha-acetyltransferase 16, NatA auxiliary subunit; Auxillary subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity."},{"id":"ENSMUSP00000061305","abundance":4.8,"rank":5780,"name":"Fbxl7","annotation":"F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest. It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5. Belongs to the FBXL7 family."},{"id":"ENSMUSP00000037966","abundance":4.8,"rank":5781,"name":"Tox","annotation":"Thymocyte selection-associated high mobility group box protein TOX; Transcriptional regulator with a major role in neural stem cell commitment and corticogenesis as well as in lymphoid cell development and lymphoid tissue organogenesis. Binds to GC-rich DNA sequences in the proximity of transcription start sites and may alter chromatin structure, modifying access of transcription factors to DNA. During cortical development, controls the neural stem cell pool by inhibiting the switch from proliferative to differentiating progenitors. Beyond progenitor cells, promotes neurite outgrowth i [...] "},{"id":"ENSMUSP00000054367","abundance":4.8,"rank":5782,"name":"Ttc19","annotation":"Tetratricopeptide repeat protein 19, mitochondrial; Required for the preservation of the structural and functional integrity of mitochondrial respiratory complex III by allowing the physiological turnover of the Rieske protein UQCRFS1. Involved in the clearance of UQCRFS1 N-terminal fragments, which are produced upon incorporation into the complex III and whose presence is detrimental for its catalytic activity."},{"id":"ENSMUSP00000032122","abundance":4.79,"rank":5783,"name":"Tacr1","annotation":"Substance-P receptor; This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin K."},{"id":"ENSMUSP00000130173","abundance":4.79,"rank":5784,"name":"Arid3b","annotation":"AT-rich interactive domain-containing protein 3B; Transcription factor involved in the production of cranial mesenchymal tissues. Favors nuclear targeting of ARID3A."},{"id":"ENSMUSP00000076253","abundance":4.79,"rank":5785,"name":"Sohlh1","annotation":"Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1; Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I."},{"id":"ENSMUSP00000036952","abundance":4.79,"rank":5786,"name":"Foxq1","annotation":"Forkhead box protein Q1; Plays a role in hair follicle differentiation."},{"id":"ENSMUSP00000050516","abundance":4.79,"rank":5787,"name":"Bhlha9","annotation":"Class A basic helix-loop-helix protein 9; Transcription factor, which play a role in limb development. Is an essential player in the regulatory network governing transcription of genes implicated in limb morphogenesis."},{"id":"ENSMUSP00000101023","abundance":4.79,"rank":5788,"name":"Ilvbl","annotation":"Acetolactate synthase-like protein; Belongs to the TPP enzyme family."},{"id":"ENSMUSP00000088297","abundance":4.78,"rank":5789,"name":"Rprd2","annotation":"Regulation of nuclear pre-mRNA domain-containing protein 2."},{"id":"ENSMUSP00000093185","abundance":4.78,"rank":5790,"name":"Fgf14","annotation":"Fibroblast growth factor 14; Probably involved in nervous system development and function."},{"id":"ENSMUSP00000089808","abundance":4.78,"rank":5791,"name":"Tmem19","annotation":"Transmembrane protein 19; Belongs to the TMEM19 family."},{"id":"ENSMUSP00000146105","abundance":4.78,"rank":5792,"name":"Xrcc1","annotation":"DNA repair protein XRCC1; Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (By similarity). Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity."},{"id":"ENSMUSP00000001226","abundance":4.77,"rank":5793,"name":"Sh3bp1","annotation":"SH3 domain-binding protein 1; GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specific [...] "},{"id":"ENSMUSP00000025197","abundance":4.77,"rank":5794,"name":"Tap2","annotation":"Antigen peptide transporter 2; Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin (By similarity); Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily."},{"id":"ENSMUSP00000019441","abundance":4.77,"rank":5795,"name":"Nop9","annotation":"Nucleolar protein 9; Belongs to the NOP9 family."},{"id":"ENSMUSP00000108734","abundance":4.77,"rank":5796,"name":"Mthfsl","annotation":"5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family."},{"id":"ENSMUSP00000061282","abundance":4.77,"rank":5797,"name":"Slc35g1","annotation":"Solute carrier family 35 member G1; May play a role in intracellular calcium sensing and homeostasis. May act as a negative regulator of plasma membrane calcium-transporting ATPases preventing calcium efflux from the cell (By similarity)."},{"id":"ENSMUSP00000004379","abundance":4.77,"rank":5798,"name":"Emg1","annotation":"Ribosomal RNA small subunit methyltransferase NEP1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre- ribos [...] "},{"id":"ENSMUSP00000131457","abundance":4.77,"rank":5799,"name":"Nup50","annotation":"Nuclear pore complex protein Nup50; Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin- alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B. This interaction is required for correct intracellular transport and degradation of CDKN1B."},{"id":"ENSMUSP00000148795","abundance":4.76,"rank":5800,"name":"Ralyl","annotation":"RNA-binding Raly-like protein."},{"id":"ENSMUSP00000029658","abundance":4.76,"rank":5801,"name":"Enpep","annotation":"Glutamyl aminopeptidase; Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II."},{"id":"ENSMUSP00000059270","abundance":4.76,"rank":5802,"name":"Gp1bb","annotation":"Platelet glycoprotein Ib beta chain; Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium."},{"id":"ENSMUSP00000006578","abundance":4.76,"rank":5803,"name":"Nectin4","annotation":"Nectin-4; Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1."},{"id":"ENSMUSP00000021523","abundance":4.76,"rank":5804,"name":"Mnat1","annotation":"CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II."},{"id":"ENSMUSP00000110558","abundance":4.75,"rank":5805,"name":"Atp6v0a4","annotation":"V-type proton ATPase 116 kDa subunit a isoform 4; Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. Belongs to the V-ATPase 116 kDa subunit family."},{"id":"ENSMUSP00000030280","abundance":4.75,"rank":5806,"name":"Angptl3","annotation":"Angiopoietin-related protein 3; Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity; the function seems to be specific for the feeding conditions. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to  [...] "},{"id":"ENSMUSP00000057339","abundance":4.75,"rank":5807,"name":"Hexim1","annotation":"Protein HEXIM1; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA- dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP- RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response [...] "},{"id":"ENSMUSP00000088779","abundance":4.75,"rank":5808,"name":"Atp11a","annotation":"Probable phospholipid-transporting ATPase IH; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity)."},{"id":"ENSMUSP00000104270","abundance":4.75,"rank":5809,"name":"Tsen34","annotation":"tRNA-splicing endonuclease subunit Sen34; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structura [...] "},{"id":"ENSMUSP00000063217","abundance":4.75,"rank":5810,"name":"Asap2","annotation":"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (By similarity)."},{"id":"ENSMUSP00000044677","abundance":4.74,"rank":5811,"name":"Thoc2","annotation":"THO complex subunit 2; Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cy [...] "},{"id":"ENSMUSP00000145322","abundance":4.74,"rank":5812,"name":"Olfr449","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000034920","abundance":4.74,"rank":5813,"name":"Map2k5","annotation":"Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis."},{"id":"ENSMUSP00000136054","abundance":4.73,"rank":5814,"name":"Llgl2","annotation":"LLGL scribble cell polarity complex component 2; Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par- 6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity (By similarity); Belongs to the WD repeat L(2)GL family."},{"id":"ENSMUSP00000095498","abundance":4.73,"rank":5815,"name":"Ago1","annotation":"Protein argonaute-1; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) or short interfering RNAs (siRNAs), and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. May also be required for transcriptional gene silencing (TGS) of promoter regions which are complementary to bound short antigene RNAs (agRNAs); Belongs to the argonaute family. Ago subfamily."},{"id":"ENSMUSP00000058008","abundance":4.73,"rank":5816,"name":"Vsig8","annotation":"V-set and immunoglobulin domain-containing protein 8."},{"id":"ENSMUSP00000034278","abundance":4.72,"rank":5817,"name":"Gins2","annotation":"DNA replication complex GINS protein PSF2; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA (By similarity)."},{"id":"ENSMUSP00000099974","abundance":4.72,"rank":5818,"name":"Wap","annotation":"Whey acidic protein; Could be a protease inhibitor. May play an important role in mammary gland development and tissue remodeling."},{"id":"ENSMUSP00000002923","abundance":4.72,"rank":5819,"name":"Adprh","annotation":"[Protein ADP-ribosylarginine] hydrolase; Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins."},{"id":"ENSMUSP00000042181","abundance":4.72,"rank":5820,"name":"Cldn11","annotation":"Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family."},{"id":"ENSMUSP00000070725","abundance":4.71,"rank":5821,"name":"Cdc42se2","annotation":"CDC42 small effector protein 2; Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T- cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity)."},{"id":"ENSMUSP00000041826","abundance":4.71,"rank":5822,"name":"Coro2b","annotation":"Coronin-2B; May play a role in the reorganization of neuronal actin structure."},{"id":"ENSMUSP00000115011","abundance":4.71,"rank":5823,"name":"Tbl2","annotation":"Transducin beta-like protein 2."},{"id":"ENSMUSP00000107678","abundance":4.71,"rank":5824,"name":"Cutc","annotation":"Copper homeostasis protein cutC homolog; May play a role in copper homeostasis. Can bind one Cu(1+) per subunit (By similarity)."},{"id":"ENSMUSP00000052968","abundance":4.71,"rank":5825,"name":"Lenep","annotation":"Lens epithelial cell protein LEP503."},{"id":"ENSMUSP00000103079","abundance":4.7,"rank":5826,"name":"Rnf183","annotation":"E3 ubiquitin-protein ligase RNF183; Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (By similarity). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (By similarity)."},{"id":"ENSMUSP00000106559","abundance":4.7,"rank":5827,"name":"Cnpy4","annotation":"Protein canopy homolog 4; Plays a role in the regulation of the cell surface expression of TLR4; Belongs to the canopy family."},{"id":"ENSMUSP00000033473","abundance":4.7,"rank":5828,"name":"Fgf13","annotation":"Fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus. May regulate voltage-gated sodium channels transport and function. May also play a role in MAPK signaling. Required for the development of axonal initial segment-targeting inhibitory GAB [...] "},{"id":"ENSMUSP00000059289","abundance":4.7,"rank":5829,"name":"Nup160","annotation":"Nuclear pore complex protein Nup160; Functions as a component of the nuclear pore complex (NPC). Involved in poly(A)+ RNA transport."},{"id":"ENSMUSP00000069774","abundance":4.7,"rank":5830,"name":"Mthfr","annotation":"Methylenetetrahydrofolate reductase; Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine."},{"id":"ENSMUSP00000021201","abundance":4.7,"rank":5831,"name":"Cpd","annotation":"Carboxypeptidase D; Belongs to the peptidase M14 family."},{"id":"ENSMUSP00000052758","abundance":4.69,"rank":5832,"name":"Itsn2","annotation":"Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes."},{"id":"ENSMUSP00000054424","abundance":4.69,"rank":5833,"name":"Rbm15","annotation":"RNA-binding protein 15; RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as hematopoietic cell homeostasis, alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involve [...] "},{"id":"ENSMUSP00000141045","abundance":4.69,"rank":5834,"name":"1700034I23Rik","annotation":"RIKEN cDNA 1700034I23 gene."},{"id":"ENSMUSP00000129023","abundance":4.69,"rank":5835,"name":"Sept10","annotation":"Septin-10; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family."},{"id":"ENSMUSP00000020899","abundance":4.69,"rank":5836,"name":"Matn3","annotation":"Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks."},{"id":"ENSMUSP00000016901","abundance":4.69,"rank":5837,"name":"Ttll12","annotation":"Tubulin--tyrosine ligase-like protein 12; Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the DDX58/RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE. Belongs to the tubulin--t [...] "},{"id":"ENSMUSP00000130452","abundance":4.68,"rank":5838,"name":"Tmem238","annotation":"Transmembrane protein 238."},{"id":"ENSMUSP00000125798","abundance":4.68,"rank":5839,"name":"Mtm1","annotation":"Myotubularin; Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology (By similarity). Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle mainte [...] "},{"id":"ENSMUSP00000047904","abundance":4.68,"rank":5840,"name":"Cmc1","annotation":"COX assembly mitochondrial protein homolog; Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly."},{"id":"ENSMUSP00000047917","abundance":4.68,"rank":5841,"name":"Vars2","annotation":"Valine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000035902","abundance":4.68,"rank":5842,"name":"Tfap2e","annotation":"Transcription factor AP-2-epsilon; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation."},{"id":"ENSMUSP00000028257","abundance":4.67,"rank":5843,"name":"Gca","annotation":"Grancalcin; Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions."},{"id":"ENSMUSP00000069371","abundance":4.67,"rank":5844,"name":"Trim23","annotation":"E3 ubiquitin-protein ligase TRIM23; Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes."},{"id":"ENSMUSP00000128173","abundance":4.67,"rank":5845,"name":"Elof1","annotation":"Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family."},{"id":"ENSMUSP00000029964","abundance":4.67,"rank":5846,"name":"Epha7","annotation":"Ephrin type-A receptor 7; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repel [...] "},{"id":"ENSMUSP00000132097","abundance":4.67,"rank":5847,"name":"Ptp4a3","annotation":"Protein tyrosine phosphatase type IVA 3; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II."},{"id":"ENSMUSP00000067341","abundance":4.66,"rank":5848,"name":"Clk3","annotation":"Dual specificity protein kinase CLK3; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre- mRNA in endothelial cells; Belongs to the protein kinase superfamily. CMGC Se [...] "},{"id":"ENSMUSP00000136645","abundance":4.66,"rank":5849,"name":"Tspan8","annotation":"Tetraspanin-8."},{"id":"ENSMUSP00000158422","abundance":4.66,"rank":5850,"name":"Pdcd1lg2","annotation":"Programmed cell death 1 ligand 2; Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production."},{"id":"ENSMUSP00000110611","abundance":4.66,"rank":5851,"name":"Kalrn","annotation":"Kalirin; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family."},{"id":"ENSMUSP00000072672","abundance":4.66,"rank":5852,"name":"Cgnl1","annotation":"Cingulin-like protein 1; May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Belongs to the cingulin family."},{"id":"ENSMUSP00000034261","abundance":4.65,"rank":5853,"name":"Insl3","annotation":"Insulin-like 3 A chain; Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor (By similarity)."},{"id":"ENSMUSP00000147061","abundance":4.65,"rank":5854,"name":"Gm45208","annotation":"PRA1 family protein."},{"id":"ENSMUSP00000027966","abundance":4.65,"rank":5855,"name":"Fcgr2b","annotation":"Low affinity immunoglobulin gamma Fc region receptor II; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activ [...] "},{"id":"ENSMUSP00000103918","abundance":4.65,"rank":5856,"name":"Pak4","annotation":"Serine/threonine-protein kinase PAK 4; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, growth, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin [...] "},{"id":"ENSMUSP00000025695","abundance":4.65,"rank":5857,"name":"Ppp2r5b","annotation":"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation."},{"id":"ENSMUSP00000048830","abundance":4.65,"rank":5858,"name":"Akr1d1","annotation":"Aldo-keto reductase family 1 member D1; Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta- hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3- one); Belongs to the aldo/keto reductase family."},{"id":"ENSMUSP00000020980","abundance":4.64,"rank":5859,"name":"Rrm2","annotation":"Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity). Belongs to the ribonucleoside diphosphate reductase small chain family."},{"id":"ENSMUSP00000040775","abundance":4.64,"rank":5860,"name":"Chst2","annotation":"Carbohydrate sulfotransferase 2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer pat [...] "},{"id":"ENSMUSP00000106038","abundance":4.64,"rank":5861,"name":"Ropn1l","annotation":"Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation."},{"id":"ENSMUSP00000076575","abundance":4.64,"rank":5862,"name":"Hmbs","annotation":"Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps; Belongs to the HMBS family."},{"id":"ENSMUSP00000023530","abundance":4.64,"rank":5863,"name":"Ropn1","annotation":"Ropporin-1; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation."},{"id":"ENSMUSP00000123253","abundance":4.64,"rank":5864,"name":"Stxbp5","annotation":"Syntaxin-binding protein 5; Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release (By similarity). Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane."},{"id":"ENSMUSP00000131365","abundance":4.63,"rank":5865,"name":"H2-M5","annotation":"Histocompatibility 2, M region locus 5; Belongs to the MHC class I family."},{"id":"ENSMUSP00000149882","abundance":4.63,"rank":5866,"name":"Adpgk","annotation":"ADP-dependent glucokinase; Catalyzes the phosphorylation of D-glucose to D-glucose 6- phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency; Belongs to the ADP-dependent glucokinase family."},{"id":"ENSMUSP00000023086","abundance":4.63,"rank":5867,"name":"Smdt1","annotation":"Essential MCU regulator, mitochondrial; Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium- sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (By s [...] "},{"id":"ENSMUSP00000043827","abundance":4.63,"rank":5868,"name":"Havcr1","annotation":"Hepatitis A virus cellular receptor 1 homolog; May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair (By similarity)."},{"id":"ENSMUSP00000098110","abundance":4.63,"rank":5869,"name":"Ly6c2","annotation":"Lymphocyte antigen 6C2."},{"id":"ENSMUSP00000107658","abundance":4.63,"rank":5870,"name":"Colq","annotation":"Acetylcholinesterase collagenic tail peptide; Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina."},{"id":"ENSMUSP00000082013","abundance":4.63,"rank":5871,"name":"Impad1","annotation":"Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; Exhibits 3'-nucleotidase activity toward adenosine 3',5'- bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'- bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, [...] "},{"id":"ENSMUSP00000029611","abundance":4.62,"rank":5872,"name":"Lef1","annotation":"Lymphoid enhancer-binding factor 1; Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1."},{"id":"ENSMUSP00000025077","abundance":4.62,"rank":5873,"name":"Mtpap","annotation":"Poly(A) RNA polymerase, mitochondrial; Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA (By similarity)."},{"id":"ENSMUSP00000122881","abundance":4.62,"rank":5874,"name":"Mfsd6","annotation":"Major facilitator superfamily domain-containing protein 6; MHC class I receptor. Binds only to H-2 class I histocompatibility antigen, K-D alpha chain (H-2K(D))."},{"id":"ENSMUSP00000102224","abundance":4.62,"rank":5875,"name":"Clcc1","annotation":"Chloride channel CLIC-like protein 1; Seems to act as a chloride ion channel (By similarity). Plays a role in retina development. Belongs to the chloride channel MCLC family."},{"id":"ENSMUSP00000053567","abundance":4.62,"rank":5876,"name":"Zfp526","annotation":"Zinc finger protein 526; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000050478","abundance":4.62,"rank":5877,"name":"Cyp4f14","annotation":"Leukotriene-B4 omega-hydroxylase 3; Cytochromes P450 are a group of heme-thiolate monooxygenases. Catalyzes the omega-hydroxylation of LTB4 (By similarity)."},{"id":"ENSMUSP00000022030","abundance":4.62,"rank":5878,"name":"Ccnh","annotation":"Cyclin-H; Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout t [...] "},{"id":"ENSMUSP00000069840","abundance":4.62,"rank":5879,"name":"Mipep","annotation":"Mitochondrial intermediate peptidase; Cleaves proteins, imported into the mitochondrion, to their mature size; Belongs to the peptidase M3 family."},{"id":"ENSMUSP00000046843","abundance":4.62,"rank":5880,"name":"Topors","annotation":"E3 ubiquitin-protein ligase Topors; Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation."},{"id":"ENSMUSP00000113103","abundance":4.62,"rank":5881,"name":"Lemd3","annotation":"Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest (By similarity)."},{"id":"ENSMUSP00000114200","abundance":4.62,"rank":5882,"name":"Lgals8","annotation":"Galectin-8; Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruse [...] "},{"id":"ENSMUSP00000113675","abundance":4.61,"rank":5883,"name":"Celf5","annotation":"CUGBP, Elav-like family member 5."},{"id":"ENSMUSP00000021277","abundance":4.61,"rank":5884,"name":"Aurkb","annotation":"Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of  [...] "},{"id":"ENSMUSP00000095420","abundance":4.61,"rank":5885,"name":"Rims1","annotation":"Regulating synaptic membrane exocytosis protein 1; Rab effector involved in exocytosis. May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity. Plays a role in dendrite formation by melanocytes (By similarity)."},{"id":"ENSMUSP00000099636","abundance":4.61,"rank":5886,"name":"Matn1","annotation":"Cartilage matrix protein; Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen."},{"id":"ENSMUSP00000021963","abundance":4.61,"rank":5887,"name":"Caml","annotation":"Calcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B."},{"id":"ENSMUSP00000045285","abundance":4.61,"rank":5888,"name":"Abca3","annotation":"ATP-binding cassette sub-family A member 3; Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol."},{"id":"ENSMUSP00000034228","abundance":4.6,"rank":5889,"name":"Arl2bp","annotation":"ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity)."},{"id":"ENSMUSP00000015866","abundance":4.6,"rank":5890,"name":"Nlrp5","annotation":"NACHT, LRR and PYD domains-containing protein 5; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions."},{"id":"ENSMUSP00000101197","abundance":4.59,"rank":5891,"name":"Perm1","annotation":"PGC-1 and ERR-induced regulator in muscle protein 1; Regulates the expression of selective PPARGC1A/B and ESRRA/B/G target genes with roles in glucose and lipid metabolism, energy transfer, contractile function, muscle mitochondrial biogenesis and oxidative capacity. Required for the efficient induction of MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT and SIRT3 by PPARGC1A. Positively regulates the PPARGC1A/ESRRG-induced expression of CKMT2, TNNI3 and SLC2A4 and negatively regulates the PPARGC1A/ESRRG-induced expression of PDK4."},{"id":"ENSMUSP00000032809","abundance":4.59,"rank":5892,"name":"Yif1b","annotation":"Protein YIF1B; Belongs to the YIF1 family."},{"id":"ENSMUSP00000077226","abundance":4.59,"rank":5893,"name":"Rsrp1","annotation":"Arginine/serine-rich protein 1; Belongs to the RSRP family."},{"id":"ENSMUSP00000036085","abundance":4.59,"rank":5894,"name":"Ammecr1","annotation":"AMME syndrome candidate gene 1 protein homolog."},{"id":"ENSMUSP00000061451","abundance":4.59,"rank":5895,"name":"Lyrm2","annotation":"LYR motif-containing protein 2; Belongs to the complex I LYR family."},{"id":"ENSMUSP00000029968","abundance":4.59,"rank":5896,"name":"Rars2","annotation":"Probable arginine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000080133","abundance":4.58,"rank":5897,"name":"Klk1b9","annotation":"Kallikrein 1-related peptidase b9; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000015278","abundance":4.58,"rank":5898,"name":"Aldh1a3","annotation":"Aldehyde dehydrogenase family 1 member A3; NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid. Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (By similarity). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region."},{"id":"ENSMUSP00000018645","abundance":4.58,"rank":5899,"name":"Ncor1","annotation":"Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (By similarity). Mediates the NR1D1-dependent repression and circadian regulation of TSHB [...] "},{"id":"ENSMUSP00000108163","abundance":4.58,"rank":5900,"name":"Gm15446","annotation":"Zinc finger protein."},{"id":"ENSMUSP00000046759","abundance":4.58,"rank":5901,"name":"Ipo8","annotation":"Importin-8; Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the c [...] "},{"id":"ENSMUSP00000048914","abundance":4.58,"rank":5902,"name":"Garem1","annotation":"GRB2-associated and regulator of MAPK protein; Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation (By similarity). Belongs to the GAREM family."},{"id":"ENSMUSP00000112491","abundance":4.58,"rank":5903,"name":"Eml2","annotation":"Echinoderm microtubule-associated protein-like 2; Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules."},{"id":"ENSMUSP00000071864","abundance":4.58,"rank":5904,"name":"Ero1lb","annotation":"ERO1-like protein beta; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Other protein disulfide isomerase family members can also be reoxidized, but at lower rates compared to P4HB, including PDIA2, PDIA3, PDIA4, PDIA6 and NXNDC12. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell (By similarity).  [...] "},{"id":"ENSMUSP00000130127","abundance":4.58,"rank":5905,"name":"Mybpc2","annotation":"Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (By similarity)."},{"id":"ENSMUSP00000082821","abundance":4.58,"rank":5906,"name":"Kctd3","annotation":"BTB/POZ domain-containing protein KCTD3; Accessory subunit of potassium/sodium hyperpolarization- activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics."},{"id":"ENSMUSP00000077021","abundance":4.57,"rank":5907,"name":"Cyp2b19","annotation":"Cytochrome P450 2B19; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000073099","abundance":4.57,"rank":5908,"name":"Epha1","annotation":"Ephrin type-A receptor 1; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment  [...] "},{"id":"ENSMUSP00000011607","abundance":4.57,"rank":5909,"name":"Cpb1","annotation":"Carboxypeptidase B1 (Tissue)."},{"id":"ENSMUSP00000030993","abundance":4.57,"rank":5910,"name":"Nelfa","annotation":"Negative elongation factor A; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (By similarity). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (By similarity)."},{"id":"ENSMUSP00000138308","abundance":4.57,"rank":5911,"name":"Dst","annotation":"Dystonin; Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for re [...] "},{"id":"ENSMUSP00000031859","abundance":4.56,"rank":5912,"name":"Trim24","annotation":"Transcription intermediary factor 1-alpha; Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac) (By similarity). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis via its effects on p53/TP53  [...] "},{"id":"ENSMUSP00000041060","abundance":4.56,"rank":5913,"name":"Kap","annotation":"Kidney androgen-regulated protein."},{"id":"ENSMUSP00000090121","abundance":4.56,"rank":5914,"name":"Cd300c2","annotation":"CMRF-35-like molecule 4; Acts as an activating receptor in mast cells and macrophages. Belongs to the CD300 family."},{"id":"ENSMUSP00000120456","abundance":4.56,"rank":5915,"name":"Ergic2","annotation":"Endoplasmic reticulum-Golgi intermediate compartment protein 2; Possible role in transport between endoplasmic reticulum and Golgi; Belongs to the ERGIC family."},{"id":"ENSMUSP00000028392","abundance":4.56,"rank":5916,"name":"Dnajc10","annotation":"DnaJ homolog subfamily C member 10; Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, [...] "},{"id":"ENSMUSP00000033325","abundance":4.56,"rank":5917,"name":"Swap70","annotation":"Switch-associated protein 70; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)."},{"id":"ENSMUSP00000111963","abundance":4.56,"rank":5918,"name":"Map7","annotation":"Ensconsin; Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments."},{"id":"ENSMUSP00000115882","abundance":4.55,"rank":5919,"name":"Med28","annotation":"Mediator of RNA polymerase II transcription subunit 28; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex [...] "},{"id":"ENSMUSP00000057600","abundance":4.55,"rank":5920,"name":"Rbpms2","annotation":"RNA-binding protein with multiple splicing 2; RNA-binding protein involved in the regulation of smooth muscle cell differentiation and proliferation in the gastrointestinal system (By similarity). Binds NOG mRNA, the major inhibitor of the bone morphogenetic protein (BMP) pathway. Mediates an increase of NOG mRNA levels, thereby contributing to the negative regulation of BMP signaling pathway and promoting reversible dedifferentiation and proliferation of smooth muscle cells (By similarity)."},{"id":"ENSMUSP00000120275","abundance":4.55,"rank":5921,"name":"Khdc1b","annotation":"KH homology domain-containing protein 1B; Belongs to the KHDC1 family."},{"id":"ENSMUSP00000034432","abundance":4.55,"rank":5922,"name":"Cfdp1","annotation":"Craniofacial development protein 1; May play a role during embryogenesis. May modulate tooth organogenesis since alterations of this protein function affect tooth organs size as well as individual cell fate and survival. In embryonic cells, blockage of the function results in increased number of apoptotic cells, reduced proliferation, alterations in cell shape and fibronection matrix synthesis."},{"id":"ENSMUSP00000147881","abundance":4.55,"rank":5923,"name":"Tfdp1","annotation":"Transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters."},{"id":"ENSMUSP00000026016","abundance":4.55,"rank":5924,"name":"Fundc1","annotation":"FUN14 domain-containing protein 1; Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control; Belongs to the FUN14 family."},{"id":"ENSMUSP00000143302","abundance":4.54,"rank":5925,"name":"Rufy3","annotation":"Protein RUFY3; Plays a role in the generation of neuronal polarity formation and axon growth. Implicated in the formation of a single axon by developing neurons. May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin- enriched protrusive structures at the cell periphery (By similarity). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones. Promotes gastric cancer cell migration and invasion in a PAK1-dependent manner [...] "},{"id":"ENSMUSP00000098910","abundance":4.54,"rank":5926,"name":"Gm614","annotation":"Uncharacterized protein CXorf65 homolog."},{"id":"ENSMUSP00000027860","abundance":4.54,"rank":5927,"name":"Xcl1","annotation":"Lymphotactin; Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment. Belongs to the intercrine gamma family."},{"id":"ENSMUSP00000126377","abundance":4.54,"rank":5928,"name":"Bcr","annotation":"Breakpoint cluster region protein; Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound t [...] "},{"id":"ENSMUSP00000007156","abundance":4.54,"rank":5929,"name":"Klk1b11","annotation":"Kallikrein 1-related peptidase b11; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000051569","abundance":4.53,"rank":5930,"name":"Mcat","annotation":"Malonyl-CoA-acyl carrier protein transacylase, mitochondrial; Catalyzes the transfer of a malonyl moiety from malonyl-CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondria (By similarity). Belongs to the type II malonyltransferase family."},{"id":"ENSMUSP00000065877","abundance":4.53,"rank":5931,"name":"Sdc3","annotation":"Syndecan-3; Cell surface proteoglycan that may bear heparan sulfate. May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism (By similarity)."},{"id":"ENSMUSP00000001339","abundance":4.53,"rank":5932,"name":"Rrp15","annotation":"RRP15-like protein."},{"id":"ENSMUSP00000050061","abundance":4.53,"rank":5933,"name":"Cyb5r2","annotation":"NADH-cytochrome b5 reductase 2; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4- disulfophenyl]-2H tetrazolium monosodium salt (WST-1) (By similarity). Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family."},{"id":"ENSMUSP00000083555","abundance":4.53,"rank":5934,"name":"Oas1g","annotation":"2'-5' oligoadenylate synthetase 1G."},{"id":"ENSMUSP00000099689","abundance":4.53,"rank":5935,"name":"Psrc1","annotation":"Proline/serine-rich coiled-coil protein 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (By similarity). Belongs to the  [...] "},{"id":"ENSMUSP00000068568","abundance":4.53,"rank":5936,"name":"Retsat","annotation":"All-trans-retinol 13,14-reductase; Catalyzes the saturation of all-trans-retinol to all-trans- 13,14-dihydroretinol. Does not exhibit any activity toward all-trans- retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers. May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism upstream of MLXIPL/ChREBP. Required for adipocyte differentiation in a 3T3-L1 cell culture model. This effect seems not to mimic the in vivo situation in which animals show increased adiposity in the absence of RETSAT. Belongs to the carotenoid/retinoi [...] "},{"id":"ENSMUSP00000152345","abundance":4.53,"rank":5937,"name":"Mrpl32","annotation":"39S ribosomal protein L32, mitochondrial; Belongs to the bacterial ribosomal protein bL32 family."},{"id":"ENSMUSP00000022875","abundance":4.52,"rank":5938,"name":"Ank","annotation":"Progressive ankylosis protein; Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter; Belongs to the ANKH family."},{"id":"ENSMUSP00000131766","abundance":4.52,"rank":5939,"name":"Syce3","annotation":"Synaptonemal complex central element protein 3; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. May play a role in apoptosis of spermatogenic cells and pathogenesis of cryptorchidism."},{"id":"ENSMUSP00000021173","abundance":4.52,"rank":5940,"name":"Mfsd11","annotation":"UNC93-like protein MFSD11."},{"id":"ENSMUSP00000051034","abundance":4.52,"rank":5941,"name":"D1Ertd622e","annotation":"Macrophage immunometabolism regulator; Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photorecept [...] "},{"id":"ENSMUSP00000019896","abundance":4.52,"rank":5942,"name":"Iyd","annotation":"Iodotyrosine deiodinase 1; Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine (By similarity)."},{"id":"ENSMUSP00000024782","abundance":4.52,"rank":5943,"name":"Pgc","annotation":"Gastricsin; Hydrolyzes a variety of proteins."},{"id":"ENSMUSP00000057406","abundance":4.52,"rank":5944,"name":"Loxl1","annotation":"Lysyl oxidase homolog 1; Active on elastin and collagen substrates."},{"id":"ENSMUSP00000040464","abundance":4.52,"rank":5945,"name":"Pbx2","annotation":"Pre-B-cell leukemia transcription factor 2; Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1 (By similarity)."},{"id":"ENSMUSP00000035800","abundance":4.52,"rank":5946,"name":"Smap2","annotation":"Stromal membrane-associated protein 2; GTPase activating protein that acts on ARF1. Can also activate ARF6 (in vitro). May play a role in clathrin-dependent retrograde transport from early endosomes to the trans-Golgi network."},{"id":"ENSMUSP00000037422","abundance":4.52,"rank":5947,"name":"Eva1a","annotation":"Protein eva-1 homolog A; Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis; Belongs to the EVA1 family."},{"id":"ENSMUSP00000130739","abundance":4.51,"rank":5948,"name":"Rbfox2","annotation":"RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue- specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity)."},{"id":"ENSMUSP00000070575","abundance":4.51,"rank":5949,"name":"Cdkn3","annotation":"Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (By similarity)."},{"id":"ENSMUSP00000066492","abundance":4.51,"rank":5950,"name":"Nup214","annotation":"Nuclear pore complex protein Nup214; Has a critical role in nucleocytoplasmic transport (By similarity). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex."},{"id":"ENSMUSP00000023203","abundance":4.51,"rank":5951,"name":"Gpt","annotation":"Alanine aminotransferase 1; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity)."},{"id":"ENSMUSP00000023670","abundance":4.51,"rank":5952,"name":"Clic6","annotation":"Chloride intracellular channel protein 6; May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity)."},{"id":"ENSMUSP00000094318","abundance":4.51,"rank":5953,"name":"Dnajc30","annotation":"DnaJ homolog subfamily C member 30, mitochondrial; Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration. Associates with the ATP synthase complex and facilitates ATP synthesis."},{"id":"ENSMUSP00000135115","abundance":4.5,"rank":5954,"name":"Pou2f3","annotation":"POU domain, class 2, transcription factor 3; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'); Belongs to the POU transcription factor family. Class-2 subfamily."},{"id":"ENSMUSP00000003808","abundance":4.5,"rank":5955,"name":"Gdf15","annotation":"Growth/differentiation factor 15; Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling."},{"id":"ENSMUSP00000079818","abundance":4.5,"rank":5956,"name":"Etv6","annotation":"Transcription factor ETV6; Transcriptional repressor; binds to the DNA sequence 5'- CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation."},{"id":"ENSMUSP00000050873","abundance":4.5,"rank":5957,"name":"1700001C19Rik","annotation":"RIKEN cDNA 1700001C19 gene."},{"id":"ENSMUSP00000130957","abundance":4.5,"rank":5958,"name":"Cnfn","annotation":"Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia."},{"id":"ENSMUSP00000032915","abundance":4.5,"rank":5959,"name":"Kif22","annotation":"Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family."},{"id":"ENSMUSP00000151054","abundance":4.5,"rank":5960,"name":"Olfr788","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000038943","abundance":4.5,"rank":5961,"name":"Selenow","annotation":"Selenoprotein W; Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency; Belongs to the SelWTH family. Selenoprotein W subfamily."},{"id":"ENSMUSP00000025007","abundance":4.49,"rank":5962,"name":"Nme4","annotation":"Nucleoside diphosphate kinase, mitochondrial; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis. Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity. Acts as mitochondria-specific NDK; its association with cardioli [...] "},{"id":"ENSMUSP00000002008","abundance":4.49,"rank":5963,"name":"Vsig2","annotation":"V-set and immunoglobulin domain-containing protein 2."},{"id":"ENSMUSP00000006053","abundance":4.49,"rank":5964,"name":"Smpd4","annotation":"Sphingomyelin phosphodiesterase 4; Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. May sensitize cells to DNA damage- induced apoptosis."},{"id":"ENSMUSP00000090316","abundance":4.49,"rank":5965,"name":"Med23","annotation":"Mediator of RNA polymerase II transcription subunit 23; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also re [...] "},{"id":"ENSMUSP00000006956","abundance":4.49,"rank":5966,"name":"Saa3","annotation":"Serum amyloid A-3 protein; Major acute phase reactant. Apolipoprotein of the HDL complex; Belongs to the SAA family."},{"id":"ENSMUSP00000126374","abundance":4.48,"rank":5967,"name":"Rbm7","annotation":"RNA-binding protein 7; RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre- mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRN [...] "},{"id":"ENSMUSP00000022343","abundance":4.48,"rank":5968,"name":"Nudt13","annotation":"Nucleoside diphosphate-linked moiety X motif 13."},{"id":"ENSMUSP00000010195","abundance":4.48,"rank":5969,"name":"Hyal1","annotation":"Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth."},{"id":"ENSMUSP00000092897","abundance":4.48,"rank":5970,"name":"Yipf3","annotation":"Protein YIPF3, N-terminally processed; Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis (By similarity); Belongs to the YIP1 family."},{"id":"ENSMUSP00000030760","abundance":4.48,"rank":5971,"name":"Necap2","annotation":"Adaptin ear-binding coat-associated protein 2; Involved in endocytosis."},{"id":"ENSMUSP00000035304","abundance":4.47,"rank":5972,"name":"Crebl2","annotation":"cAMP-responsive element-binding protein-like 2; Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle."},{"id":"ENSMUSP00000005862","abundance":4.47,"rank":5973,"name":"Tfap4","annotation":"Transcription factor AP4."},{"id":"ENSMUSP00000112905","abundance":4.47,"rank":5974,"name":"Gm20489","annotation":"Predicted gene 20489."},{"id":"ENSMUSP00000013766","abundance":4.47,"rank":5975,"name":"Atraid","annotation":"All-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway (By similarity)."},{"id":"ENSMUSP00000000122","abundance":4.47,"rank":5976,"name":"Ngfr","annotation":"Tumor necrosis factor receptor superfamily member 16; Low affinity neurotrophin receptor which can bind to mature NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF (proNGF), BDNF (proBDNF) and NTF3 (proNT3) with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. The heterodimeric receptor formed with SORCS2 plays a role in proBDNF-dependent  [...] "},{"id":"ENSMUSP00000019268","abundance":4.47,"rank":5977,"name":"Scrn1","annotation":"Secernin-1; Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity)."},{"id":"ENSMUSP00000028199","abundance":4.47,"rank":5978,"name":"Tor1b","annotation":"Torsin-1B; May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. Plays a role in non- neural cells nuclear envelope and endoplasmic reticulum integrity. May have a redundant function with TOR1A in non-neural tissues."},{"id":"ENSMUSP00000008745","abundance":4.47,"rank":5979,"name":"Rab25","annotation":"Ras-related protein Rab-25; Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity)."},{"id":"ENSMUSP00000001921","abundance":4.46,"rank":5980,"name":"Cpa3","annotation":"Mast cell carboxypeptidase A."},{"id":"ENSMUSP00000101032","abundance":4.46,"rank":5981,"name":"Icosl","annotation":"ICOS ligand; Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function. During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype; Belongs to the immunoglobulin superfamily. BTN/MOG family."},{"id":"ENSMUSP00000047712","abundance":4.46,"rank":5982,"name":"Cbr3","annotation":"Carbonyl reductase [NADPH] 3; Has low NADPH-dependent oxidoreductase activity towards 4- benzoylpyridine and menadione (in vitro)."},{"id":"ENSMUSP00000021328","abundance":4.46,"rank":5983,"name":"Lyzl6","annotation":"Lysozyme-like protein 6; May be involved sperm-egg plasma membrane adhesion and fusion during fertilization. Exhibits bacteriolytic activity in vitro against Micrococcus luteus and Staphylococcus aureus. Shows weak bacteriolytic activity against Gram-positive bacteria at physiological pH. Bacteriolytic activity is pH-dependent, with a maximum at around pH 5.6 (By similarity); Belongs to the glycosyl hydrolase 22 family."},{"id":"ENSMUSP00000109877","abundance":4.46,"rank":5984,"name":"Samsn1","annotation":"SAM domain-containing protein SAMSN-1; Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation."},{"id":"ENSMUSP00000101903","abundance":4.46,"rank":5985,"name":"Usp36","annotation":"Ubiquitin carboxyl-terminal hydrolase 36; Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiq [...] "},{"id":"ENSMUSP00000110636","abundance":4.46,"rank":5986,"name":"Tcf4","annotation":"Transcription factor 4; Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'- CANNTG-3'). Isoform 2 inhibits MYOD1 activation of the cardiac alpha- actin promoter. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. May have a regulatory function in developmental processes as well as during neuronal plasticity."},{"id":"ENSMUSP00000110389","abundance":4.46,"rank":5987,"name":"Pstpip2","annotation":"Proline-serine-threonine phosphatase-interacting protein 2; Binds to F-actin. May be involved in regulation of the actin cytoskeleton."},{"id":"ENSMUSP00000150107","abundance":4.46,"rank":5988,"name":"Olfr684","annotation":"Olfactory receptor Olfr684."},{"id":"ENSMUSP00000062046","abundance":4.45,"rank":5989,"name":"Cox19","annotation":"Cytochrome c oxidase assembly protein COX19; Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. May be required for the assembly of mitochondrial cytochrome c oxidase."},{"id":"ENSMUSP00000056719","abundance":4.45,"rank":5990,"name":"Gtf3c1","annotation":"General transcription factor 3C polypeptide 1; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity)."},{"id":"ENSMUSP00000134388","abundance":4.45,"rank":5991,"name":"Chek1","annotation":"Serine/threonine-protein kinase Chk1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. This inhibits their activity through proteasomal degradation [...] "},{"id":"ENSMUSP00000034368","abundance":4.45,"rank":5992,"name":"Ctrl","annotation":"Chymotrypsin A CTRA-1; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000030154","abundance":4.45,"rank":5993,"name":"Nudt2","annotation":"Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis (By similarity)."},{"id":"ENSMUSP00000072852","abundance":4.45,"rank":5994,"name":"Ctdspl","annotation":"CTD small phosphatase-like protein; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity)."},{"id":"ENSMUSP00000067496","abundance":4.45,"rank":5995,"name":"Siah2","annotation":"E3 ubiquitin-protein ligase SIAH2; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. Promotes monoubiquitinat [...] "},{"id":"ENSMUSP00000074198","abundance":4.45,"rank":5996,"name":"Nfatc2","annotation":"Nuclear factor of activated T-cells, cytoplasmic 2; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. Promotes invasive migration through the activation of GPC6 expression and WNT5A signaling pathway."},{"id":"ENSMUSP00000076563","abundance":4.44,"rank":5997,"name":"Dmac2","annotation":"Distal membrane-arm assembly complex protein 2; Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I."},{"id":"ENSMUSP00000034512","abundance":4.44,"rank":5998,"name":"Oaf","annotation":"Out at first protein homolog; Belongs to the OAF family."},{"id":"ENSMUSP00000102095","abundance":4.44,"rank":5999,"name":"Mast2","annotation":"Microtubule-associated serine/threonine-protein kinase 2; Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation."},{"id":"ENSMUSP00000057096","abundance":4.44,"rank":6000,"name":"Dsg2","annotation":"Desmoglein-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion."},{"id":"ENSMUSP00000105583","abundance":4.44,"rank":6001,"name":"Serpina3j","annotation":"Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J; Belongs to the serpin family."},{"id":"ENSMUSP00000021810","abundance":4.44,"rank":6002,"name":"Id4","annotation":"DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation."},{"id":"ENSMUSP00000037609","abundance":4.43,"rank":6003,"name":"Bri3bp","annotation":"BRI3-binding protein; Involved in tumorigenesis and may function by stabilizing p53/TP53."},{"id":"ENSMUSP00000017900","abundance":4.43,"rank":6004,"name":"Slc12a7","annotation":"Solute carrier family 12 member 7; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (By similarity). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification."},{"id":"ENSMUSP00000004936","abundance":4.43,"rank":6005,"name":"Ccl24","annotation":"C-C motif chemokine 24; Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Binds to CCR3 (By similarity); Belongs to the intercrine beta (chemokine CC) family."},{"id":"ENSMUSP00000004910","abundance":4.43,"rank":6006,"name":"Eif2b2","annotation":"Translation initiation factor eIF-2B subunit beta; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family."},{"id":"ENSMUSP00000025963","abundance":4.43,"rank":6007,"name":"Noc3l","annotation":"Nucleolar complex protein 3 homolog; May be required for adipogenesis."},{"id":"ENSMUSP00000127773","abundance":4.43,"rank":6008,"name":"Kcne1l","annotation":"Potassium voltage-gated channel subfamily E regulatory beta subunit 5; Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta- subunit of the repolarizing cardiac potassium ion channel KCNQ1."},{"id":"ENSMUSP00000108815","abundance":4.43,"rank":6009,"name":"Atg16l1","annotation":"Autophagy-related protein 16-1; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. Regulates mitochondrial antiviral signaling (MAVS)-dependent type I interferon (IFN-I) production (By similarity). Negatively regulates NOD1- and NOD2-driven inflammatory cytokine response. Instead, promotes with NOD2 an autophagy-dependent antibacterial pa [...] "},{"id":"ENSMUSP00000016672","abundance":4.42,"rank":6010,"name":"Mapkapk2","annotation":"MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] "},{"id":"ENSMUSP00000112766","abundance":4.42,"rank":6011,"name":"Tent4b","annotation":"Terminal nucleotidyltransferase 4B; Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA sub [...] "},{"id":"ENSMUSP00000070726","abundance":4.42,"rank":6012,"name":"Ppp2r5a","annotation":"Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment; Belongs to the phosphatase 2A regulatory subunit B56 family."},{"id":"ENSMUSP00000088663","abundance":4.42,"rank":6013,"name":"Phyhd1","annotation":"Phytanoyl-CoA dioxygenase domain-containing protein 1; Has alpha-ketoglutarate-dependent dioxygenase activity. Does not show detectable activity towards fatty acid CoA thioesters. Is not expected to be active with phytanoyl CoA (By similarity). Belongs to the PhyH family. PHYHD1 subfamily."},{"id":"ENSMUSP00000033820","abundance":4.42,"rank":6014,"name":"F7","annotation":"Coagulation factor VII; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity)."},{"id":"ENSMUSP00000020258","abundance":4.42,"rank":6015,"name":"Herc4","annotation":"Probable E3 ubiquitin-protein ligase HERC4; Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates."},{"id":"ENSMUSP00000021158","abundance":4.42,"rank":6016,"name":"Txndc17","annotation":"Thioredoxin domain-containing protein 17; Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide (By similarity); Belongs to the thioredoxin family."},{"id":"ENSMUSP00000124529","abundance":4.41,"rank":6017,"name":"Pag1","annotation":"Phosphoprotein associated with glycosphingolipid-enriched microdomains 1; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling."},{"id":"ENSMUSP00000026893","abundance":4.41,"rank":6018,"name":"Tgm4","annotation":"Protein-glutamine gamma-glutamyltransferase 4; Associated with the mammalian reproductive process. Plays an important role in the formation of the seminal coagulum through the cross-linking of specific proteins present in the seminal plasma. Transglutaminase is also required to stabilize the copulatory plug."},{"id":"ENSMUSP00000014686","abundance":4.41,"rank":6019,"name":"Clec4f","annotation":"C-type lectin domain family 4 member F; Receptor with an affinity for galactose and fucose. Could be involved in endocytosis."},{"id":"ENSMUSP00000040240","abundance":4.41,"rank":6020,"name":"1700066M21Rik","annotation":"UPF0565 protein C2orf69 homolog."},{"id":"ENSMUSP00000101194","abundance":4.41,"rank":6021,"name":"Plekhn1","annotation":"Kelch-like protein 17; Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity)."},{"id":"ENSMUSP00000080256","abundance":4.41,"rank":6022,"name":"Acnat2","annotation":"Acyl-coenzyme A amino acid N-acyltransferase 2; Acyltransferase which efficiently conjugates very long-chain and long-chain fatty acids to taurine. Shows no conjugation activity in the presence of glycine (By similarity)."},{"id":"ENSMUSP00000097793","abundance":4.41,"rank":6023,"name":"Spout1","annotation":"Putative methyltransferase C9orf114 homolog; Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. Also involved in chromosome alignment. May promote centrosome maturation probably by recruiting A-kinase anchor protein AKAP9 to centrosomes in early mitosis. Binds specifically to miRNA MIR145 hairpin, regulates MIR145 expression at a postranscriptional level (By similarity)."},{"id":"ENSMUSP00000030588","abundance":4.4,"rank":6024,"name":"Phc2","annotation":"Polyhomeotic-like protein 2; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility."},{"id":"ENSMUSP00000103747","abundance":4.4,"rank":6025,"name":"Spata5","annotation":"ATPase family protein 2 homolog; ATP-dependent chaperone which uses the energy provided by ATP hydrolysis to generate mechanical force to disassemble protein complexes (By similarity). May be involved in morphological and functional mitochondrial transformations during spermatogenesis."},{"id":"ENSMUSP00000052989","abundance":4.4,"rank":6026,"name":"Cyp8b1","annotation":"7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7 alpha, 12 alpha- dihydroxy-4-cholesten-3-one. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. Has a rather broad substrate specificity including a number of 7-alpha-hydroxylated C27 steroids."},{"id":"ENSMUSP00000004968","abundance":4.4,"rank":6027,"name":"Plod3","annotation":"Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3; Multifunctional enzyme that catalyzes a series of post- translational modifications on Lys residues in procollagen. Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5- hydroxylysine (By similarity). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2- glucosylgalactosyl-5-hydroxylys [...] "},{"id":"ENSMUSP00000078415","abundance":4.39,"rank":6028,"name":"Speer4a","annotation":"Spermatogenesis-associated glutamate (E)-rich protein 4A."},{"id":"ENSMUSP00000028161","abundance":4.39,"rank":6029,"name":"Cel","annotation":"Bile salt-activated lipase; Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFAs). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs. Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity)."},{"id":"ENSMUSP00000084005","abundance":4.39,"rank":6030,"name":"Barhl2","annotation":"BarH-like 2 homeobox protein; Potential regulator of neural basic helix-loop-helix genes. It may down-regulate expression of ASCL1 and, within the thalamus, up- regulate NGN2, thereby regulating distinct patterns of neuronal differentiation (By similarity); Belongs to the BAR homeobox family."},{"id":"ENSMUSP00000064680","abundance":4.39,"rank":6031,"name":"Junb","annotation":"Transcription factor jun-B; Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'; Belongs to the bZIP family. Jun subfamily."},{"id":"ENSMUSP00000110477","abundance":4.39,"rank":6032,"name":"Eaf2","annotation":"ELL-associated factor 2; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities (By similarity). Acts as a transcriptional transactivator of TCEA1 elongation activity; Belongs to the EAF family."},{"id":"ENSMUSP00000135819","abundance":4.39,"rank":6033,"name":"Ccdc190","annotation":"Coiled-coil domain-containing protein 190."},{"id":"ENSMUSP00000033276","abundance":4.38,"rank":6034,"name":"Uros","annotation":"Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity). Belongs to the uroporphyrinogen-III synthase family."},{"id":"ENSMUSP00000027991","abundance":4.38,"rank":6035,"name":"Rgs4","annotation":"Regulator of G-protein signaling 4; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)- alpha-1 is inhibited by palmitoylation of the G-protein (By similarity)."},{"id":"ENSMUSP00000093236","abundance":4.38,"rank":6036,"name":"Cldn9","annotation":"Claudin-9; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity."},{"id":"ENSMUSP00000067774","abundance":4.38,"rank":6037,"name":"Cpne8","annotation":"Copine-8; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes."},{"id":"ENSMUSP00000128941","abundance":4.38,"rank":6038,"name":"Enpp2","annotation":"Ectonucleotide pyrophosphatase/phosphodiesterase family member 2; Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubul [...] "},{"id":"ENSMUSP00000075839","abundance":4.38,"rank":6039,"name":"Irf6","annotation":"Interferon regulatory factor 6; Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Belongs to the IRF family."},{"id":"ENSMUSP00000093091","abundance":4.38,"rank":6040,"name":"Akap3","annotation":"A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Belongs to the AKAP110 family."},{"id":"ENSMUSP00000106441","abundance":4.37,"rank":6041,"name":"Spint1","annotation":"Kunitz-type protease inhibitor 1; Inhibitor of HGF activator."},{"id":"ENSMUSP00000054530","abundance":4.37,"rank":6042,"name":"Fut8","annotation":"Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans."},{"id":"ENSMUSP00000107726","abundance":4.37,"rank":6043,"name":"Rnf10","annotation":"RING finger protein 10; Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression and myelin formation in Schwann cells; Belongs to the RNF10 family."},{"id":"ENSMUSP00000100561","abundance":4.37,"rank":6044,"name":"Sowaha","annotation":"Ankyrin repeat domain-containing protein SOWAHA; Belongs to the SOWAH family."},{"id":"ENSMUSP00000021956","abundance":4.37,"rank":6045,"name":"Ddx41","annotation":"Probable ATP-dependent RNA helicase DDX41; Probable ATP-dependent RNA helicase. Is required during post- transcriptional gene expression. May be involved in pre-mRNA splicing."},{"id":"ENSMUSP00000098256","abundance":4.37,"rank":6046,"name":"Ear1","annotation":"Eosinophil cationic protein 1; Cytotoxin and helminthotoxin with ribonuclease activity. Possesses a wide variety of biological activities (By similarity). Belongs to the pancreatic ribonuclease family."},{"id":"ENSMUSP00000125453","abundance":4.37,"rank":6047,"name":"Pard3","annotation":"Partitioning defective 3 homolog; Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon [...] "},{"id":"ENSMUSP00000027297","abundance":4.36,"rank":6048,"name":"Plekhb2","annotation":"Pleckstrin homology domain-containing family B member 2; Involved in retrograde transport of recycling endosomes."},{"id":"ENSMUSP00000070445","abundance":4.36,"rank":6049,"name":"Grk3","annotation":"Beta-adrenergic receptor kinase 2; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors."},{"id":"ENSMUSP00000109794","abundance":4.36,"rank":6050,"name":"Nrp2","annotation":"Neuropilin-2; High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF."},{"id":"ENSMUSP00000018122","abundance":4.36,"rank":6051,"name":"Cadps2","annotation":"Calcium-dependent secretion activator 2; Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates neurotrophin release from granule cells leading to regulate cell differentiation and survival during cerebellar development. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles."},{"id":"ENSMUSP00000034488","abundance":4.36,"rank":6052,"name":"Mmp10","annotation":"Stromelysin-2; Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase; Belongs to the peptidase M10A family."},{"id":"ENSMUSP00000134112","abundance":4.36,"rank":6053,"name":"Gm20441","annotation":"Predicted gene 20441."},{"id":"ENSMUSP00000107858","abundance":4.36,"rank":6054,"name":"Mvk","annotation":"Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily."},{"id":"ENSMUSP00000028852","abundance":4.36,"rank":6055,"name":"Mrps5","annotation":"28S ribosomal protein S5, mitochondrial; Belongs to the universal ribosomal protein uS5 family."},{"id":"ENSMUSP00000124344","abundance":4.36,"rank":6056,"name":"Arl4c","annotation":"ADP-ribosylation factor-like protein 4C; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. May be involved in transport between a perinuclear compartment and the plasma membrane, apparently linked to the ABCA1-mediated cholesterol secretion pathway. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in th [...] "},{"id":"ENSMUSP00000025137","abundance":4.35,"rank":6057,"name":"Thoc1","annotation":"THO complex subunit 1; Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre- mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the T [...] "},{"id":"ENSMUSP00000070259","abundance":4.35,"rank":6058,"name":"Csnk1g3","annotation":"Casein kinase I isoform gamma-3; Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Regulates fast synaptic transmission mediated by glutamate."},{"id":"ENSMUSP00000026012","abundance":4.35,"rank":6059,"name":"Cyp17a1","annotation":"Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids,  [...] "},{"id":"ENSMUSP00000040599","abundance":4.35,"rank":6060,"name":"Vnn1","annotation":"Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine."},{"id":"ENSMUSP00000122831","abundance":4.35,"rank":6061,"name":"Cenpa","annotation":"Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By simila [...] "},{"id":"ENSMUSP00000047333","abundance":4.35,"rank":6062,"name":"Zbtb7a","annotation":"Zinc finger and BTB domain-containing protein 7A; Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation. Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions. Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms (By similarity). That is, recruits the chromati [...] "},{"id":"ENSMUSP00000102771","abundance":4.35,"rank":6063,"name":"Rsf1","annotation":"Remodeling and spacing factor 1."},{"id":"ENSMUSP00000045856","abundance":4.35,"rank":6064,"name":"Svep1","annotation":"Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; May play a role in the cell attachment process."},{"id":"ENSMUSP00000084327","abundance":4.34,"rank":6065,"name":"Mrgpra4","annotation":"Mas-related G-protein coupled receptor member A4; Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain."},{"id":"ENSMUSP00000101520","abundance":4.34,"rank":6066,"name":"Shank2","annotation":"SH3 and multiple ankyrin repeat domains protein 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction (By similarity)."},{"id":"ENSMUSP00000030138","abundance":4.34,"rank":6067,"name":"Nol6","annotation":"Nucleolar protein 6; Belongs to the NRAP family."},{"id":"ENSMUSP00000021803","abundance":4.34,"rank":6068,"name":"Nup153","annotation":"Nucleoporin 153."},{"id":"ENSMUSP00000022115","abundance":4.34,"rank":6069,"name":"Xrcc4","annotation":"DNA repair protein XRCC4; Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends (By similarity)."},{"id":"ENSMUSP00000104015","abundance":4.33,"rank":6070,"name":"Coq8b","annotation":"Atypical kinase COQ8B, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration."},{"id":"ENSMUSP00000094239","abundance":4.33,"rank":6071,"name":"Med14","annotation":"Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000028200","abundance":4.33,"rank":6072,"name":"Tor1a","annotation":"Torsin-1A; Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular traffickin [...] "},{"id":"ENSMUSP00000034146","abundance":4.33,"rank":6073,"name":"Ucp1","annotation":"Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] "},{"id":"ENSMUSP00000025409","abundance":4.33,"rank":6074,"name":"Lox","annotation":"Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture."},{"id":"ENSMUSP00000104165","abundance":4.32,"rank":6075,"name":"Sult2a5","annotation":"Sulfotransferase; Belongs to the sulfotransferase 1 family."},{"id":"ENSMUSP00000069247","abundance":4.32,"rank":6076,"name":"Spink6","annotation":"Serine protease inhibitor Kazal-type 6; Serine protease inhibitor selective for kallikreins. Efficiently inhibits KLK5 and human KLK2, KLK4, KLK5, KLK6, KLK7, KLK12, KLK13 and KLK14. Doesn't inhibit human KLK1 and KLK8."},{"id":"ENSMUSP00000035048","abundance":4.32,"rank":6077,"name":"Cldn18","annotation":"Claudin-18; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family."},{"id":"ENSMUSP00000153208","abundance":4.32,"rank":6078,"name":"Tspan14","annotation":"Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6. Promotes ADAM10-mediated cleavage of CDH5."},{"id":"ENSMUSP00000147439","abundance":4.32,"rank":6079,"name":"Kcnj11","annotation":"ATP-sensitive inward rectifier potassium channel 11; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. Can form cardiac and smo [...] "},{"id":"ENSMUSP00000104641","abundance":4.32,"rank":6080,"name":"Shroom1","annotation":"Protein Shroom1; May be involved in the assembly of microtubule arrays during cell elongation."},{"id":"ENSMUSP00000111378","abundance":4.32,"rank":6081,"name":"Nrg2","annotation":"Pro-neuregulin-2, membrane-bound isoform; Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor; Belongs to the neuregulin family."},{"id":"ENSMUSP00000029165","abundance":4.32,"rank":6082,"name":"Rab5if","annotation":"Respirasome Complex Assembly Factor 1; Acts as an assembly factor for mitochondrial respiratory complexes."},{"id":"ENSMUSP00000055404","abundance":4.32,"rank":6083,"name":"Hamp","annotation":"Hepcidin; Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes; Belongs to the hepcidin family."},{"id":"ENSMUSP00000003529","abundance":4.31,"rank":6084,"name":"Paf1","annotation":"RNA polymerase II-associated factor 1 homolog; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription  [...] "},{"id":"ENSMUSP00000119356","abundance":4.31,"rank":6085,"name":"Actl6b","annotation":"Actin-like protein 6B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. [...] "},{"id":"ENSMUSP00000026142","abundance":4.31,"rank":6086,"name":"Maged1","annotation":"Melanoma-associated antigen D1; Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl- conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA coregulator, modulating the expression  [...] "},{"id":"ENSMUSP00000048377","abundance":4.31,"rank":6087,"name":"Utp4","annotation":"U3 small nucleolar RNA-associated protein 4 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. Required for optimal pre- ribosomal RNA transcription by RNA polymerase. May be a transcriptional regulator. Acts as a positive regulator of HIVEP1."},{"id":"ENSMUSP00000068927","abundance":4.31,"rank":6088,"name":"Cebpe","annotation":"CCAAT/enhancer-binding protein epsilon; Transcriptional activator. C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation; Belongs to the bZIP family. C/EBP subfamily."},{"id":"ENSMUSP00000099885","abundance":4.3,"rank":6089,"name":"Stk10","annotation":"Serine/threonine-protein kinase 10; Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo."},{"id":"ENSMUSP00000004343","abundance":4.3,"rank":6090,"name":"Wars2","annotation":"Tryptophan--tRNA ligase, mitochondrial; Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis."},{"id":"ENSMUSP00000075722","abundance":4.3,"rank":6091,"name":"Ces2f","annotation":"Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000043146","abundance":4.3,"rank":6092,"name":"Shc4","annotation":"SHC-transforming protein 4; Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1."},{"id":"ENSMUSP00000042875","abundance":4.3,"rank":6093,"name":"Appl1","annotation":"DCC-interacting protein 13-alpha; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism (By similarity). Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1. Inhibits Fc-gamma recep [...] "},{"id":"ENSMUSP00000066314","abundance":4.3,"rank":6094,"name":"Ppp4r2","annotation":"Serine/threonine-protein phosphatase 4 regulatory subunit 2; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair (By similarity). Mediates RPA2  [...] "},{"id":"ENSMUSP00000032237","abundance":4.3,"rank":6095,"name":"Bms1","annotation":"BMS1 homolog, ribosome assembly protein (Yeast)."},{"id":"ENSMUSP00000021345","abundance":4.29,"rank":6096,"name":"Gtf2a1","annotation":"Transcription initiation factor IIA alpha chain; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity (By similarity); Belongs to the TFIIA subunit 1 family."},{"id":"ENSMUSP00000046302","abundance":4.29,"rank":6097,"name":"Bbox1","annotation":"Gamma-butyrobetaine dioxygenase; Catalyzes the formation of L-carnitine from gamma- butyrobetaine; Belongs to the gamma-BBH/TMLD family."},{"id":"ENSMUSP00000099553","abundance":4.29,"rank":6098,"name":"Tmigd1","annotation":"Transmembrane and immunoglobulin domain-containing protein 1; May control cell-cell adhesion, cell migration and proliferation, cell morphology, and protects renal epithelial cells from oxidative cell injury to promote cell survival."},{"id":"ENSMUSP00000062214","abundance":4.29,"rank":6099,"name":"Prodh2","annotation":"Hydroxyproline dehydrogenase; Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L- hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis."},{"id":"ENSMUSP00000109818","abundance":4.29,"rank":6100,"name":"Taz","annotation":"Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism."},{"id":"ENSMUSP00000112725","abundance":4.29,"rank":6101,"name":"Farp2","annotation":"FERM, ARHGEF and pleckstrin domain-containing protein 2; Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (and. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11- mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion."},{"id":"ENSMUSP00000149068","abundance":4.29,"rank":6102,"name":"Olfr339","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000023918","abundance":4.28,"rank":6103,"name":"Ivns1abp","annotation":"Influenza virus NS1A-binding protein homolog; Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (By similarity). In addition, functio [...] "},{"id":"ENSMUSP00000046188","abundance":4.28,"rank":6104,"name":"Rab24","annotation":"Ras-related protein Rab-24; May be involved in autophagy-related processes; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000050823","abundance":4.28,"rank":6105,"name":"Cyp20a1","annotation":"Cytochrome P450 20A1; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000129575","abundance":4.28,"rank":6106,"name":"Dpy19l1","annotation":"Probable C-mannosyltransferase DPY19L1; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins."},{"id":"ENSMUSP00000107477","abundance":4.27,"rank":6107,"name":"Ttn","annotation":"Titin; Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase."},{"id":"ENSMUSP00000071202","abundance":4.27,"rank":6108,"name":"Chchd1","annotation":"Coiled-coil-helix-coiled-coil-helix domain-containing protein 1; Belongs to the mitochondrion-specific ribosomal protein mS37 family."},{"id":"ENSMUSP00000066304","abundance":4.27,"rank":6109,"name":"Nlgn3","annotation":"Neuroligin-3; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000026550","abundance":4.26,"rank":6110,"name":"Inpp5a","annotation":"Inositol polyphosphate-5-phosphatase A."},{"id":"ENSMUSP00000029588","abundance":4.26,"rank":6111,"name":"Larp7","annotation":"La-related protein 7; Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation."},{"id":"ENSMUSP00000112975","abundance":4.26,"rank":6112,"name":"Sgpl1","annotation":"Sphingosine-1-phosphate lyase 1; Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro- inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and  [...] "},{"id":"ENSMUSP00000071035","abundance":4.26,"rank":6113,"name":"Smad1","annotation":"Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression."},{"id":"ENSMUSP00000004133","abundance":4.26,"rank":6114,"name":"Brinp2","annotation":"BMP/retinoic acid-inducible neural-specific protein 2; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition; Belongs to the BRINP family."},{"id":"ENSMUSP00000024984","abundance":4.26,"rank":6115,"name":"Tmem204","annotation":"Transmembrane protein 204; Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens (By similarity)."},{"id":"ENSMUSP00000040429","abundance":4.26,"rank":6116,"name":"Pbxip1","annotation":"Pre-B-cell leukemia transcription factor-interacting protein 1; Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor- alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity)."},{"id":"ENSMUSP00000151447","abundance":4.26,"rank":6117,"name":"Tbxa2r","annotation":"Thromboxane A2 receptor; Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C and adenylyl cyclase."},{"id":"ENSMUSP00000100019","abundance":4.26,"rank":6118,"name":"Prl2b1","annotation":"Prolactin-2B1; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000065009","abundance":4.26,"rank":6119,"name":"Gpatch2","annotation":"G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro."},{"id":"ENSMUSP00000073311","abundance":4.26,"rank":6120,"name":"Inca1","annotation":"Protein INCA1; Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor. Inhibits cell growth and proliferation and may play a role in cell cycle control. Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth."},{"id":"ENSMUSP00000100010","abundance":4.26,"rank":6121,"name":"Exoc2","annotation":"Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family."},{"id":"ENSMUSP00000108508","abundance":4.25,"rank":6122,"name":"Gpat3","annotation":"Glycerol-3-phosphate acyltransferase 3; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity)."},{"id":"ENSMUSP00000113729","abundance":4.25,"rank":6123,"name":"Slc7a2","annotation":"Cationic amino acid transporter 2; Isoform 1 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Isoform 2 also functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), but it has much higher affinity for arginine than isoform 1. May play a role in classical or alternative activation of macrophages via its role in arginine transport."},{"id":"ENSMUSP00000126194","abundance":4.25,"rank":6124,"name":"Dtnb","annotation":"Dystrobrevin beta."},{"id":"ENSMUSP00000035452","abundance":4.25,"rank":6125,"name":"Nfkbil1","annotation":"NF-kappa-B inhibitor-like protein 1; Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity)."},{"id":"ENSMUSP00000145281","abundance":4.24,"rank":6126,"name":"Ghrl","annotation":"Appetite-regulating hormone; Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation; Belongs to the motilin family."},{"id":"ENSMUSP00000142054","abundance":4.24,"rank":6127,"name":"Rcor3","annotation":"REST corepressor 3; May act as a component of a corepressor complex that represses transcription."},{"id":"ENSMUSP00000087912","abundance":4.24,"rank":6128,"name":"Cd59b","annotation":"CD59B glycoprotein; Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (By similarity)."},{"id":"ENSMUSP00000028914","abundance":4.24,"rank":6129,"name":"Polr3f","annotation":"DNA-directed RNA polymerase III subunit RPC6; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRN [...] "},{"id":"ENSMUSP00000027059","abundance":4.24,"rank":6130,"name":"Tfap2b","annotation":"Transcription factor AP-2-beta; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and f [...] "},{"id":"ENSMUSP00000028900","abundance":4.24,"rank":6131,"name":"Vps16","annotation":"Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late  [...] "},{"id":"ENSMUSP00000157208","abundance":4.24,"rank":6132,"name":"BC004004","annotation":"Bombesin receptor-activated protein C6orf89 homolog; Exhibits histone deacetylase (HDAC) enhancer properties. May play a role in cell cycle progression and wound repair of bronchial epithelial cells."},{"id":"ENSMUSP00000028644","abundance":4.24,"rank":6133,"name":"Cd82","annotation":"CD82 antigen; Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway; Belongs to the tetraspanin (TM4SF) family."},{"id":"ENSMUSP00000105027","abundance":4.23,"rank":6134,"name":"Pkig","annotation":"cAMP-dependent protein kinase inhibitor gamma; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains."},{"id":"ENSMUSP00000038335","abundance":4.23,"rank":6135,"name":"Rabif","annotation":"Guanine nucleotide exchange factor MSS4; Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport (By similarity). Belongs to the DSS4/MSS4 family."},{"id":"ENSMUSP00000130271","abundance":4.23,"rank":6136,"name":"1600014C10Rik","annotation":"Protein C19orf12 homolog."},{"id":"ENSMUSP00000069779","abundance":4.23,"rank":6137,"name":"9130008F23Rik","annotation":"RIKEN cDNA 9130008F23 gene."},{"id":"ENSMUSP00000069666","abundance":4.23,"rank":6138,"name":"Nkx2-2","annotation":"Homeobox protein Nkx-2.2; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas. May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter."},{"id":"ENSMUSP00000127439","abundance":4.22,"rank":6139,"name":"Spert","annotation":"Protein chibby homolog 2; Belongs to the chibby family. SPERT subfamily."},{"id":"ENSMUSP00000126066","abundance":4.22,"rank":6140,"name":"Zfp185","annotation":"Zinc finger protein 185; May be involved in the regulation of cellular proliferation and/or differentiation."},{"id":"ENSMUSP00000098074","abundance":4.22,"rank":6141,"name":"Brat1","annotation":"BRCA1-associated ATM activator 1; Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation (By similarity). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors."},{"id":"ENSMUSP00000059741","abundance":4.22,"rank":6142,"name":"Tceanc2","annotation":"Transcription elongation factor A N-terminal and central domain-containing protein 2."},{"id":"ENSMUSP00000039656","abundance":4.22,"rank":6143,"name":"Nup205","annotation":"Nucleoporin 205."},{"id":"ENSMUSP00000098486","abundance":4.22,"rank":6144,"name":"Tex52","annotation":"Testis-expressed protein 52."},{"id":"ENSMUSP00000019060","abundance":4.22,"rank":6145,"name":"Csf2","annotation":"Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes."},{"id":"ENSMUSP00000021898","abundance":4.22,"rank":6146,"name":"Shc3","annotation":"SHC-transforming protein 3; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity)."},{"id":"ENSMUSP00000104844","abundance":4.22,"rank":6147,"name":"B4galt5","annotation":"Beta-1,4-galactosyltransferase 5; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation. Plays a role in the glycosylation of BMPR1A and regulation of its protein stability. Essential for extraembryonic development during early embryogenesis."},{"id":"ENSMUSP00000096487","abundance":4.21,"rank":6148,"name":"Smcp","annotation":"Sperm mitochondrial-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida."},{"id":"ENSMUSP00000029256","abundance":4.21,"rank":6149,"name":"Sec62","annotation":"Translocation protein SEC62; Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen."},{"id":"ENSMUSP00000024059","abundance":4.21,"rank":6150,"name":"Sva","annotation":"Seminal vesicle antigen."},{"id":"ENSMUSP00000094075","abundance":4.21,"rank":6151,"name":"Kcnj4","annotation":"Inward rectifier potassium channel 4; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity)."},{"id":"ENSMUSP00000093197","abundance":4.21,"rank":6152,"name":"Susd2","annotation":"Sushi domain-containing protein 2; May be a cytokine receptor for C10ORF99. May be a tumor suppressor; together with C10ORF99 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (By similarity). May play a role in breast tumorigenesis."},{"id":"ENSMUSP00000128669","abundance":4.21,"rank":6153,"name":"Mmgt2","annotation":"Membrane magnesium transporter 2; Mediates Mg(2+) transport; Belongs to the membrane magnesium transporter (TC 1.A.67) family."},{"id":"ENSMUSP00000132512","abundance":4.2,"rank":6154,"name":"Cacna2d2","annotation":"Voltage-dependent calcium channel subunit alpha-2/delta-2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G)."},{"id":"ENSMUSP00000154983","abundance":4.2,"rank":6155,"name":"Acap2","annotation":"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6)."},{"id":"ENSMUSP00000066927","abundance":4.2,"rank":6156,"name":"Gata4","annotation":"Transcription factor GATA-4; Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (By similarity). In cooperation with TBX5, it binds to cardiac super- enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression (By similarity). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a trans [...] "},{"id":"ENSMUSP00000117025","abundance":4.2,"rank":6157,"name":"Agpat5","annotation":"1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C15:0-C20:4 at the sn-1 position using C18:1-CoA as the acyl donor (By similarity). Also acts on lysophosphatidylethanolamine using oleoyl-CoA, but not arachidonoyl- CoA, and lysophosphatidylinositol using arachidonoyl-CoA, but not oleoyl-CoA (By similarity).  [...] "},{"id":"ENSMUSP00000058686","abundance":4.2,"rank":6158,"name":"H2-M10.4","annotation":"Histocompatibility 2, M region locus 10.4; Belongs to the MHC class I family."},{"id":"ENSMUSP00000020551","abundance":4.2,"rank":6159,"name":"Asb3","annotation":"Ankyrin repeat and SOCS box protein 3; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B (By similarity)."},{"id":"ENSMUSP00000078641","abundance":4.19,"rank":6160,"name":"Nsmce2","annotation":"E3 SUMO-protein ligase NSE2; E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, th [...] "},{"id":"ENSMUSP00000025322","abundance":4.19,"rank":6161,"name":"H2-M10.1","annotation":"Histocompatibility 2, M region locus 10.1; Belongs to the MHC class I family."},{"id":"ENSMUSP00000024733","abundance":4.19,"rank":6162,"name":"Aars2","annotation":"Alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000052465","abundance":4.19,"rank":6163,"name":"Wdr36","annotation":"WD repeat domain 36."},{"id":"ENSMUSP00000087264","abundance":4.19,"rank":6164,"name":"Vmn1r19","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000054338","abundance":4.19,"rank":6165,"name":"Map7d1","annotation":"MAP7 domain-containing protein 1; Belongs to the MAP7 family."},{"id":"ENSMUSP00000043703","abundance":4.19,"rank":6166,"name":"Ptk7","annotation":"Inactive tyrosine-protein kinase 7; Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis."},{"id":"ENSMUSP00000007757","abundance":4.19,"rank":6167,"name":"Tgfbr1","annotation":"TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] "},{"id":"ENSMUSP00000117954","abundance":4.18,"rank":6168,"name":"Podxl2","annotation":"Podocalyxin-like protein 2; Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins (By similarity); Belongs to the podocalyxin family."},{"id":"ENSMUSP00000111483","abundance":4.18,"rank":6169,"name":"Celf4","annotation":"CUGBP Elav-like family member 4; RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic site [...] "},{"id":"ENSMUSP00000018212","abundance":4.18,"rank":6170,"name":"Ints2","annotation":"Integrator complex subunit 2; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex."},{"id":"ENSMUSP00000100649","abundance":4.18,"rank":6171,"name":"Fam43b","annotation":"Family with sequence similarity 43, member B."},{"id":"ENSMUSP00000129012","abundance":4.18,"rank":6172,"name":"Lamtor5","annotation":"Ragulator complex protein LAMTOR5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assem [...] "},{"id":"ENSMUSP00000015791","abundance":4.18,"rank":6173,"name":"Lama5","annotation":"Laminin subunit alpha-5; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae."},{"id":"ENSMUSP00000104543","abundance":4.18,"rank":6174,"name":"Phactr3","annotation":"Phosphatase and actin regulator 3."},{"id":"ENSMUSP00000002327","abundance":4.18,"rank":6175,"name":"Def6","annotation":"Differentially expressed in FDCP 6; Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of systemic autoimmunity (By similarity)."},{"id":"ENSMUSP00000020792","abundance":4.18,"rank":6176,"name":"Btnl10","annotation":"Butyrophilin-like protein 10; Belongs to the immunoglobulin superfamily. BTN/MOG family."},{"id":"ENSMUSP00000017836","abundance":4.18,"rank":6177,"name":"Rhbdl3","annotation":"Rhomboid-related protein 3; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors; Belongs to the peptidase S54 family."},{"id":"ENSMUSP00000006828","abundance":4.17,"rank":6178,"name":"Aplp1","annotation":"Amyloid-like protein 1; May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G- protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I; Belongs to the APP family."},{"id":"ENSMUSP00000026021","abundance":4.17,"rank":6179,"name":"Msr1","annotation":"Macrophage scavenger receptor types I and II; Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL)."},{"id":"ENSMUSP00000021471","abundance":4.17,"rank":6180,"name":"Tmx1","annotation":"Thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions."},{"id":"ENSMUSP00000084055","abundance":4.17,"rank":6181,"name":"Tcf7","annotation":"Transcription factor 7; Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1 (By similarity); Belongs to the TCF/LEF family."},{"id":"ENSMUSP00000070791","abundance":4.17,"rank":6182,"name":"Tas2r136","annotation":"Taste receptor type 2 member 136; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000045621","abundance":4.17,"rank":6183,"name":"Decr2","annotation":"Peroxisomal 2,4-dienoyl-CoA reductase; Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid; Belongs to the short-chain dehydrogenases/reductas [...] "},{"id":"ENSMUSP00000113812","abundance":4.17,"rank":6184,"name":"4930550L24Rik","annotation":"RIKEN cDNA 4930550L24 gene."},{"id":"ENSMUSP00000133709","abundance":4.17,"rank":6185,"name":"Aif1","annotation":"Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation."},{"id":"ENSMUSP00000060118","abundance":4.16,"rank":6186,"name":"Ppp1r2","annotation":"Protein phosphatase inhibitor 2; Inhibitor of protein-phosphatase 1."},{"id":"ENSMUSP00000100979","abundance":4.16,"rank":6187,"name":"Tcf3","annotation":"Transcription factor E2-alpha; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B- cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region."},{"id":"ENSMUSP00000057670","abundance":4.16,"rank":6188,"name":"Fam174a","annotation":"Membrane protein FAM174A."},{"id":"ENSMUSP00000044048","abundance":4.16,"rank":6189,"name":"Mcl1","annotation":"Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 2 has antiapoptotic activity."},{"id":"ENSMUSP00000108192","abundance":4.16,"rank":6190,"name":"Cypt3","annotation":"Cysteine-rich perinuclear theca 3."},{"id":"ENSMUSP00000088291","abundance":4.16,"rank":6191,"name":"Otud7b","annotation":"OTU domain-containing protein 7B; Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF- kappa-B. Negatively regulates mucosal immunity against infections. Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activ [...] "},{"id":"ENSMUSP00000084257","abundance":4.16,"rank":6192,"name":"Xpo5","annotation":"Exportin-5; Mediates the nuclear export of proteins bearing a double- stranded RNA binding domain (dsRBD) and double-stranded RNAs (cargos). XPO5 in the nucleus binds cooperatively to the RNA and to the GTPase Ran in its active GTP-bound form. Proteins containing dsRBDs can associate with this trimeric complex through the RNA. Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause disassembly of [...] "},{"id":"ENSMUSP00000033230","abundance":4.16,"rank":6193,"name":"Tha1","annotation":"L-threonine aldolase."},{"id":"ENSMUSP00000041241","abundance":4.16,"rank":6194,"name":"Smg7","annotation":"Protein SMG7; Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation (By similarity)."},{"id":"ENSMUSP00000027753","abundance":4.16,"rank":6195,"name":"Lamc2","annotation":"Laminin subunit gamma-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."},{"id":"ENSMUSP00000101919","abundance":4.15,"rank":6196,"name":"Zfp553","annotation":"Zinc finger protein 48; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000072074","abundance":4.15,"rank":6197,"name":"Ggt5","annotation":"Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4)."},{"id":"ENSMUSP00000045361","abundance":4.15,"rank":6198,"name":"Parl","annotation":"Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals. Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) (By similarity). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity)."},{"id":"ENSMUSP00000030684","abundance":4.15,"rank":6199,"name":"Gnl2","annotation":"Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity)."},{"id":"ENSMUSP00000056131","abundance":4.15,"rank":6200,"name":"Acot6","annotation":"Acyl-coenzyme A thioesterase 6; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 6/ACOT6 catalyzes the hydrolysis of phytanoyl-CoA and pristanoyl-CoA, two methyl-branched fatty acids derived from phytol, that enter the body via the diet."},{"id":"ENSMUSP00000032473","abundance":4.15,"rank":6201,"name":"Iigp1","annotation":"Interferon-inducible GTPase 1; GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction. Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family."},{"id":"ENSMUSP00000104752","abundance":4.14,"rank":6202,"name":"Zfp354b","annotation":"Zinc finger protein 354B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000077132","abundance":4.14,"rank":6203,"name":"Itga1","annotation":"Integrin alpha-1; Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth."},{"id":"ENSMUSP00000032409","abundance":4.14,"rank":6204,"name":"Camk1","annotation":"Calcium/calmodulin-dependent protein kinase type 1; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in h [...] "},{"id":"ENSMUSP00000088982","abundance":4.13,"rank":6205,"name":"Skida1","annotation":"SKI/DACH domain-containing protein 1; Belongs to the DACH/dachshund family."},{"id":"ENSMUSP00000035179","abundance":4.13,"rank":6206,"name":"Nudt16","annotation":"U8 snoRNA-decapping enzyme; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less  [...] "},{"id":"ENSMUSP00000045110","abundance":4.13,"rank":6207,"name":"Ppp1r14c","annotation":"Protein phosphatase 1 regulatory subunit 14C; Inhibitor of the PP1 regulatory subunit PPP1CA."},{"id":"ENSMUSP00000128105","abundance":4.13,"rank":6208,"name":"Fiz1","annotation":"Flt3-interacting zinc finger protein 1; May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity)."},{"id":"ENSMUSP00000120938","abundance":4.13,"rank":6209,"name":"Sh3rf3","annotation":"E3 ubiquitin-protein ligase SH3RF3; Has E3 ubiquitin-protein ligase activity."},{"id":"ENSMUSP00000137875","abundance":4.12,"rank":6210,"name":"Ndfip2","annotation":"NEDD4 family-interacting protein 2; Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (By similarity). May modu [...] "},{"id":"ENSMUSP00000065719","abundance":4.12,"rank":6211,"name":"Plpp3","annotation":"Phospholipid phosphatase 3; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z- octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of the [...] "},{"id":"ENSMUSP00000020969","abundance":4.11,"rank":6212,"name":"Cmpk2","annotation":"UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity)."},{"id":"ENSMUSP00000039360","abundance":4.11,"rank":6213,"name":"Ppl","annotation":"Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling."},{"id":"ENSMUSP00000101311","abundance":4.11,"rank":6214,"name":"Slc25a33","annotation":"Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and m [...] "},{"id":"ENSMUSP00000107503","abundance":4.11,"rank":6215,"name":"Arpp21","annotation":"cAMP-regulated phosphoprotein 21; Isoform 2 may act as a competitive inhibitor of calmodulin- dependent enzymes such as calcineurin in neurons."},{"id":"ENSMUSP00000057527","abundance":4.1,"rank":6216,"name":"Tle4","annotation":"Transducin-like enhancer protein 4; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression."},{"id":"ENSMUSP00000063800","abundance":4.1,"rank":6217,"name":"Ifng","annotation":"Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons."},{"id":"ENSMUSP00000041477","abundance":4.1,"rank":6218,"name":"Rpp25l","annotation":"Ribonuclease P protein subunit p25-like protein; May be a component of ribonuclease P or MRP; Belongs to the histone-like Alba family."},{"id":"ENSMUSP00000034373","abundance":4.1,"rank":6219,"name":"Dpep2","annotation":"Dipeptidase 2; Probable metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4)."},{"id":"ENSMUSP00000021918","abundance":4.1,"rank":6220,"name":"Ror2","annotation":"Tyrosine-protein kinase transmembrane receptor ROR2; Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity)."},{"id":"ENSMUSP00000106684","abundance":4.1,"rank":6221,"name":"Ephb4","annotation":"Ephrin type-B receptor 4; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and bl [...] "},{"id":"ENSMUSP00000074225","abundance":4.09,"rank":6222,"name":"8030462N17Rik","annotation":"Uncharacterized protein C18orf25 homolog."},{"id":"ENSMUSP00000060143","abundance":4.09,"rank":6223,"name":"Grrp1","annotation":"Protein FAM110D; Belongs to the FAM110 family."},{"id":"ENSMUSP00000068677","abundance":4.09,"rank":6224,"name":"Zcchc24","annotation":"Zinc finger CCHC domain-containing protein 24."},{"id":"ENSMUSP00000058055","abundance":4.09,"rank":6225,"name":"1700001O22Rik","annotation":"RIKEN cDNA 1700001O22 gene."},{"id":"ENSMUSP00000069821","abundance":4.09,"rank":6226,"name":"Spag16","annotation":"Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia."},{"id":"ENSMUSP00000058114","abundance":4.09,"rank":6227,"name":"E130311K13Rik","annotation":"Protein C3orf33 homolog; May play a role in transcription regulation."},{"id":"ENSMUSP00000029794","abundance":4.09,"rank":6228,"name":"Them5","annotation":"Acyl-coenzyme A thioesterase THEM5; Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (By similarity). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin. Required for normal mitochondrial function."},{"id":"ENSMUSP00000019058","abundance":4.09,"rank":6229,"name":"Il3","annotation":"Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages."},{"id":"ENSMUSP00000065836","abundance":4.08,"rank":6230,"name":"Nup188","annotation":"Nucleoporin NUP188 homolog; May function as a component of the nuclear pore complex (NPC)."},{"id":"ENSMUSP00000099794","abundance":4.08,"rank":6231,"name":"Gcg","annotation":"Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia (By similarity). GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a [...] "},{"id":"ENSMUSP00000104162","abundance":4.07,"rank":6232,"name":"Sult2a1","annotation":"Bile salt sulfotransferase 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze sulfonation of hydroxysteroids and xenobiotics; Belongs to the sulfotransferase 1 family."},{"id":"ENSMUSP00000030765","abundance":4.07,"rank":6233,"name":"Padi2","annotation":"Protein-arginine deiminase type-2; Catalyzes the deimination of arginine residues of proteins."},{"id":"ENSMUSP00000103184","abundance":4.07,"rank":6234,"name":"Mef2d","annotation":"Myocyte-specific enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis."},{"id":"ENSMUSP00000020655","abundance":4.06,"rank":6235,"name":"Jade2","annotation":"E3 ubiquitin-protein ligase Jade-2; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo (By similarity). Acts as a E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone demethylase KDM1A. Also acts as a ubiquitin ligase E3 toward itself. Positive regulator of neurogenesis."},{"id":"ENSMUSP00000030896","abundance":4.06,"rank":6236,"name":"Tprgl","annotation":"Tumor protein p63-regulated gene 1-like protein; Presynaptic protein involved in the synaptic transmission tuning. Regulates synaptic release probability by decreasing the calcium sensitivity of release; Belongs to the TPRG1 family."},{"id":"ENSMUSP00000031327","abundance":4.06,"rank":6237,"name":"Cxcl1","annotation":"Growth-regulated alpha protein; Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity; Belongs to the intercrine alpha (chemokine CxC) family."},{"id":"ENSMUSP00000111412","abundance":4.06,"rank":6238,"name":"Clcn5","annotation":"H(+)/Cl(-) exchange transporter 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity); Belongs to the chloride channel (TC 2.A.49) family. ClC- 5/CLCN5 subfamily."},{"id":"ENSMUSP00000044494","abundance":4.06,"rank":6239,"name":"Gria1","annotation":"Glutamate receptor 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulati [...] "},{"id":"ENSMUSP00000026475","abundance":4.06,"rank":6240,"name":"Ddit3","annotation":"DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] "},{"id":"ENSMUSP00000123336","abundance":4.06,"rank":6241,"name":"Hal","annotation":"Histidine ammonia-lyase; Belongs to the PAL/histidase family."},{"id":"ENSMUSP00000092268","abundance":4.06,"rank":6242,"name":"Wipf1","annotation":"WAS/WASL-interacting protein family member 1; Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation (By similarity). Plays a role in the formation of cell ruffles."},{"id":"ENSMUSP00000085915","abundance":4.05,"rank":6243,"name":"Smgc","annotation":"Submandibular gland protein C."},{"id":"ENSMUSP00000036177","abundance":4.05,"rank":6244,"name":"Rad9b","annotation":"Cell cycle checkpoint control protein RAD9B."},{"id":"ENSMUSP00000104274","abundance":4.05,"rank":6245,"name":"Nlgn2","annotation":"Neuroligin-2; Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 a [...] "},{"id":"ENSMUSP00000049044","abundance":4.05,"rank":6246,"name":"Immp1l","annotation":"Mitochondrial inner membrane protease subunit 1; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity)."},{"id":"ENSMUSP00000071130","abundance":4.05,"rank":6247,"name":"Alox5ap","annotation":"Arachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity); Belongs to the MAPEG family."},{"id":"ENSMUSP00000096876","abundance":4.05,"rank":6248,"name":"Cd93","annotation":"Complement component C1q receptor; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. Marker for early multipotent hematopoietic precursor cells. May play a role in cell-cell interactions during hematopoietic and vascular development."},{"id":"ENSMUSP00000006660","abundance":4.04,"rank":6249,"name":"Prl7a2","annotation":"Prolactin-7A2."},{"id":"ENSMUSP00000110425","abundance":4.04,"rank":6250,"name":"Pias2","annotation":"E3 SUMO-protein ligase PIAS2; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoyla [...] "},{"id":"ENSMUSP00000079210","abundance":4.04,"rank":6251,"name":"Col25a1","annotation":"Collagen-like Alzheimer amyloid plaque component; Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity)."},{"id":"ENSMUSP00000006377","abundance":4.04,"rank":6252,"name":"Zbtb17","annotation":"Zinc finger and BTB domain-containing protein 17; Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commi [...] "},{"id":"ENSMUSP00000044028","abundance":4.04,"rank":6253,"name":"Spertl","annotation":"Spermatid-associated-like."},{"id":"ENSMUSP00000019026","abundance":4.03,"rank":6254,"name":"Mrpl45","annotation":"39S ribosomal protein L45, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL45 family."},{"id":"ENSMUSP00000088375","abundance":4.03,"rank":6255,"name":"Lce3f","annotation":"Late cornified envelope 3F."},{"id":"ENSMUSP00000050666","abundance":4.03,"rank":6256,"name":"Lce3c","annotation":"Late cornified envelope 3C."},{"id":"ENSMUSP00000098591","abundance":4.03,"rank":6257,"name":"Inf2","annotation":"Inverted formin-2; Severs actin filaments and accelerates their polymerization and depolymerization; Belongs to the formin homology family."},{"id":"ENSMUSP00000067066","abundance":4.03,"rank":6258,"name":"Lif","annotation":"Leukemia inhibitory factor; LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes; Belongs to the LIF/OSM family."},{"id":"ENSMUSP00000065631","abundance":4.02,"rank":6259,"name":"Tpk1","annotation":"Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate."},{"id":"ENSMUSP00000083273","abundance":4.02,"rank":6260,"name":"Prkd2","annotation":"Serine/threonine-protein kinase D2; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of cell proliferation via MAPK1/3 (ERK1/2) signaling, oxidative stress-induced NF-kappa-B activation, inhibition of HDAC7 transcriptional repression, signaling downstream of T-cell antigen receptor (TCR) and cytokine production, and plays a role in Golgi membrane trafficking, angiogenesis, secretory granule release and cell adhesion. May potentiate mitogenesis induced by the neu [...] "},{"id":"ENSMUSP00000102630","abundance":4.02,"rank":6261,"name":"Hsd3b1","annotation":"3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo- Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlli [...] "},{"id":"ENSMUSP00000099705","abundance":4.02,"rank":6262,"name":"Med19","annotation":"Mediator of RNA polymerase II transcription subunit 19; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000138433","abundance":4.02,"rank":6263,"name":"Prrc2c","annotation":"Protein PRRC2C."},{"id":"ENSMUSP00000080632","abundance":4.02,"rank":6264,"name":"Odf1","annotation":"Outer dense fiber protein 1; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail."},{"id":"ENSMUSP00000057557","abundance":4.01,"rank":6265,"name":"Hdgfl1","annotation":"Hepatoma derived growth factor-like 1."},{"id":"ENSMUSP00000027020","abundance":4.01,"rank":6266,"name":"Gria4","annotation":"Glutamate receptor 4; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of  [...] "},{"id":"ENSMUSP00000120362","abundance":4.01,"rank":6267,"name":"Gpc6","annotation":"Secreted glypican-6; Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases. Enhances migration and invasion of cancer cells through WNT5A signaling (By similarity)."},{"id":"ENSMUSP00000113113","abundance":4.01,"rank":6268,"name":"Nkain3","annotation":"Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 3; Belongs to the NKAIN family."},{"id":"ENSMUSP00000047923","abundance":4.01,"rank":6269,"name":"Colgalt1","annotation":"Procollagen galactosyltransferase 1; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV. Belongs to the glycosyltransferase 25 family."},{"id":"ENSMUSP00000073964","abundance":4.01,"rank":6270,"name":"Klk1b5","annotation":"Kallikrein 1-related peptidase b5; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000018577","abundance":4.01,"rank":6271,"name":"Nol11","annotation":"Nucleolar protein 11; Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b (By similarity)."},{"id":"ENSMUSP00000103528","abundance":4,"rank":6272,"name":"Trim25","annotation":"E3 ubiquitin/ISG15 ligase TRIM25; Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates e [...] "},{"id":"ENSMUSP00000118779","abundance":4,"rank":6273,"name":"Immp2l","annotation":"Mitochondrial inner membrane protease subunit 2; Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO (By similarity)."},{"id":"ENSMUSP00000069080","abundance":4,"rank":6274,"name":"Casr","annotation":"Extracellular calcium-sensing receptor; G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (By similarity). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (By similarity). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino  [...] "},{"id":"ENSMUSP00000036705","abundance":4,"rank":6275,"name":"Gak","annotation":"Cyclin-G-associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family."},{"id":"ENSMUSP00000035551","abundance":4,"rank":6276,"name":"Avp","annotation":"Vasopressin-neurophysin 2-copeptin; Neurophysin 2 specifically binds vasopressin; Belongs to the vasopressin/oxytocin family."},{"id":"ENSMUSP00000031538","abundance":4,"rank":6277,"name":"2210016L21Rik","annotation":"Protein CUSTOS; Plays a role in the regulation of Wnt signaling pathway during early development; Belongs to the CUSTOS family."},{"id":"ENSMUSP00000135448","abundance":4,"rank":6278,"name":"Hmbox1","annotation":"Homeobox-containing protein 1; Binds directly to 5'-TTAGGG-3' repeats in telomeric DNA (By similarity). Associates with the telomerase complex at sites of active telomere processing and positively regulates telomere elongation (By similarity). Important for TERT binding to chromatin, indicating a role in recruitment of the telomerase complex to telomeres. Also plays a role in the alternative lengthening of telomeres (ALT) pathway in telomerase-negative cells where it promotes formation and/or maintenance of ALT-associated promyelocytic leukemia bodies (APBs) (By similarity). Enhances f [...] "},{"id":"ENSMUSP00000020754","abundance":3.99,"rank":6279,"name":"Cfap36","annotation":"Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family."},{"id":"ENSMUSP00000053384","abundance":3.99,"rank":6280,"name":"Trim3","annotation":"Tripartite motif-containing protein 3; Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B."},{"id":"ENSMUSP00000113174","abundance":3.99,"rank":6281,"name":"Stim2","annotation":"Stromal interaction molecule 2; Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRA [...] "},{"id":"ENSMUSP00000047700","abundance":3.99,"rank":6282,"name":"Chmp7","annotation":"Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family."},{"id":"ENSMUSP00000025058","abundance":3.99,"rank":6283,"name":"Anks1","annotation":"Ankyrin repeat and SAM domain-containing protein 1A; Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction."},{"id":"ENSMUSP00000023147","abundance":3.99,"rank":6284,"name":"Ciita","annotation":"MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirem [...] "},{"id":"ENSMUSP00000004480","abundance":3.98,"rank":6285,"name":"Sst","annotation":"Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin."},{"id":"ENSMUSP00000003550","abundance":3.98,"rank":6286,"name":"Ncstn","annotation":"Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels; Belongs to the nicastrin family."},{"id":"ENSMUSP00000049528","abundance":3.98,"rank":6287,"name":"Rbbp6","annotation":"E3 ubiquitin-protein ligase RBBP6; E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation. Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abun [...] "},{"id":"ENSMUSP00000030848","abundance":3.98,"rank":6288,"name":"Rbp7","annotation":"Retinoid-binding protein 7; Intracellular transport of retinol; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family."},{"id":"ENSMUSP00000040611","abundance":3.97,"rank":6289,"name":"Tcfl5","annotation":"Transcription factor-like 5 (basic helix-loop-helix)."},{"id":"ENSMUSP00000007433","abundance":3.97,"rank":6290,"name":"Kiss1","annotation":"Metastasis-suppressor KiSS-1; Metastasis suppressor protein. May regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. Generates a C-terminally amidated peptide, metastin which functions as the endogenous ligand of the G-protein coupled receptor GPR54. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is also essential for normal gonadotropin-released hormone physiology and for puberty. The hypothalamic KiSS1/GPR54 system is a pivotal factor in central regulation  [...] "},{"id":"ENSMUSP00000142264","abundance":3.97,"rank":6291,"name":"Gm28040","annotation":"Predicted gene, 28040."},{"id":"ENSMUSP00000081569","abundance":3.97,"rank":6292,"name":"Rgs3","annotation":"Regulator of G-protein signaling 3; Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein- mediated release of inositol phosphates and activation of MAP kinases."},{"id":"ENSMUSP00000023629","abundance":3.97,"rank":6293,"name":"Pros1","annotation":"Vitamin K-dependent protein S; Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis."},{"id":"ENSMUSP00000123238","abundance":3.97,"rank":6294,"name":"Reps1","annotation":"RalBP1-associated Eps domain-containing protein 1; May coordinate the cellular actions of activated EGF receptors and Ral-GTPases."},{"id":"ENSMUSP00000078806","abundance":3.97,"rank":6295,"name":"Zfp398","annotation":"Zinc finger protein 398."},{"id":"ENSMUSP00000033664","abundance":3.97,"rank":6296,"name":"Il2rg","annotation":"Cytokine receptor common subunit gamma; Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15 (By similarity)."},{"id":"ENSMUSP00000043492","abundance":3.97,"rank":6297,"name":"Setd7","annotation":"Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys- 1 [...] "},{"id":"ENSMUSP00000150277","abundance":3.97,"rank":6298,"name":"Cyp1a1","annotation":"Cytochrome P450 1A1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy [...] "},{"id":"ENSMUSP00000152602","abundance":3.97,"rank":6299,"name":"Klhl28","annotation":"Kelch-like protein 28."},{"id":"ENSMUSP00000039088","abundance":3.97,"rank":6300,"name":"Vsx1","annotation":"Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster (By similarity). May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development."},{"id":"ENSMUSP00000065254","abundance":3.97,"rank":6301,"name":"Slc30a7","annotation":"Zinc transporter 7; Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity)."},{"id":"ENSMUSP00000053431","abundance":3.97,"rank":6302,"name":"Vat1l","annotation":"Synaptic vesicle membrane protein VAT-1 homolog-like; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily."},{"id":"ENSMUSP00000031822","abundance":3.96,"rank":6303,"name":"Abcg2","annotation":"Broad substrate specificity ATP-binding cassette transporter ABCG2; Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells. Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme. Also mediates the efflux of sphingosine-1-P from cells (By similarity). Acts as a urate exporter functioning in both [...] "},{"id":"ENSMUSP00000079179","abundance":3.96,"rank":6304,"name":"Yaf2","annotation":"YY1-associated factor 2; Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling."},{"id":"ENSMUSP00000112226","abundance":3.96,"rank":6305,"name":"Bex4","annotation":"Protein BEX4; May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate to the control of cell cycle progression and genomic stability; Belongs to the BEX family."},{"id":"ENSMUSP00000024786","abundance":3.96,"rank":6306,"name":"Tfeb","annotation":"Transcription factor EB; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'- GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate the [...] "},{"id":"ENSMUSP00000083899","abundance":3.96,"rank":6307,"name":"Mtcl1","annotation":"Microtubule cross-linking factor 1; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation. Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells. Belongs to the SOGA family."},{"id":"ENSMUSP00000027198","abundance":3.96,"rank":6308,"name":"Orc2","annotation":"Origin recognition complex subunit 2; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity)."},{"id":"ENSMUSP00000080842","abundance":3.96,"rank":6309,"name":"Scn8a","annotation":"Sodium channel protein type 8 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages, isoform 5 may participate in the control of podosome and invadopodia formation."},{"id":"ENSMUSP00000002625","abundance":3.95,"rank":6310,"name":"Uck1","annotation":"Uridine-cytidine kinase 1; Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6- azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)- acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine (By similarity)."},{"id":"ENSMUSP00000110690","abundance":3.95,"rank":6311,"name":"Robo3","annotation":"Roundabout homolog 3; Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing ; Belongs to the immunoglobulin superfamily. ROBO family."},{"id":"ENSMUSP00000099793","abundance":3.95,"rank":6312,"name":"Fap","annotation":"Antiplasmin-cleaving enzyme FAP, soluble form; Cell surface glycoprotein serine protease that participates in extracellular matrix degradation and involved in many cellular processes including tissue remodeling, fibrosis, wound healing, inflammation and tumor growth. Both plasma membrane and soluble forms exhibit post-proline cleaving endopeptidase activity, with a marked preference for Ala/Ser-Gly-Pro-Ser/Asn/Ala consensus sequences, on substrate such as alpha-2-antiplasmin SERPINF2 and SPRY2. Degrade also gelatin, heat-denatured type I collagen, but not native collagen type I and IV, [...] "},{"id":"ENSMUSP00000110115","abundance":3.95,"rank":6313,"name":"Cblb","annotation":"E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs [...] "},{"id":"ENSMUSP00000157273","abundance":3.95,"rank":6314,"name":"Sbpl","annotation":"Spermine-binding protein-like."},{"id":"ENSMUSP00000006750","abundance":3.95,"rank":6315,"name":"Rundc3a","annotation":"RUN domain-containing protein 3A; May act as an effector of RAP2A in neuronal cells. Belongs to the RUNDC3 family."},{"id":"ENSMUSP00000069505","abundance":3.95,"rank":6316,"name":"Nr1d1","annotation":"Nuclear receptor subfamily 1 group D member 1; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARTNL/BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for [...] "},{"id":"ENSMUSP00000022908","abundance":3.94,"rank":6317,"name":"Slc25a32","annotation":"Mitochondrial folate transporter/carrier; Transports folate across the inner membranes of mitochondria. Can also transport FAD across the mitochondrial inner membrane (By similarity)."},{"id":"ENSMUSP00000109548","abundance":3.94,"rank":6318,"name":"Klhl15","annotation":"Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. Acts as an adapter for CUL3 to target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits and regulating PP2A holoenzyme composition. Acts as an adapter for CUL3 to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, plays a key role in DNA damage response,  [...] "},{"id":"ENSMUSP00000071794","abundance":3.94,"rank":6319,"name":"Cpsf1","annotation":"Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity)."},{"id":"ENSMUSP00000099373","abundance":3.94,"rank":6320,"name":"Zfp334","annotation":"Zinc finger protein 334."},{"id":"ENSMUSP00000126279","abundance":3.94,"rank":6321,"name":"Ptprk","annotation":"Receptor-type tyrosine-protein phosphatase kappa; Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily."},{"id":"ENSMUSP00000128308","abundance":3.94,"rank":6322,"name":"Thbs2","annotation":"Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions. Ligand for CD36 mediating antiangiogenic properties."},{"id":"ENSMUSP00000113819","abundance":3.94,"rank":6323,"name":"Grm4","annotation":"Metabotropic glutamate receptor 4; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity (By similarity)."},{"id":"ENSMUSP00000024699","abundance":3.93,"rank":6324,"name":"Cldn6","annotation":"Claudin-6; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family."},{"id":"ENSMUSP00000059977","abundance":3.93,"rank":6325,"name":"Ptgs1","annotation":"Prostaglandin G/H synthase 1; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells."},{"id":"ENSMUSP00000058521","abundance":3.93,"rank":6326,"name":"Atf2","annotation":"Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the c [...] "},{"id":"ENSMUSP00000037939","abundance":3.93,"rank":6327,"name":"Ube2q1","annotation":"Ubiquitin-conjugating enzyme E2 Q1; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Involved in female fertility and embryo implantation. May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation."},{"id":"ENSMUSP00000034076","abundance":3.93,"rank":6328,"name":"Cbln1","annotation":"[des-Ser1]-cerebellin; Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber- Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part b [...] "},{"id":"ENSMUSP00000107887","abundance":3.93,"rank":6329,"name":"Selenok","annotation":"Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration. Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation. Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced a [...] "},{"id":"ENSMUSP00000046525","abundance":3.93,"rank":6330,"name":"Scara3","annotation":"Scavenger receptor class A member 3; Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation."},{"id":"ENSMUSP00000063358","abundance":3.93,"rank":6331,"name":"1700016K19Rik","annotation":"Protein LIAT1; May be involved in ATE1-mediated N-terminal arginylation."},{"id":"ENSMUSP00000136167","abundance":3.93,"rank":6332,"name":"Etfbkmt","annotation":"Electron transfer flavoprotein beta subunit lysine methyltransferase; Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria. Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases."},{"id":"ENSMUSP00000092693","abundance":3.93,"rank":6333,"name":"Actl7b","annotation":"Actin-like protein 7B; Belongs to the actin family."},{"id":"ENSMUSP00000000776","abundance":3.92,"rank":6334,"name":"Tubgcp3","annotation":"Gamma-tubulin complex component 3; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome."},{"id":"ENSMUSP00000066822","abundance":3.92,"rank":6335,"name":"Penk","annotation":"Met-enkephalin-Arg-Ser-Leu; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum."},{"id":"ENSMUSP00000145754","abundance":3.92,"rank":6336,"name":"Sh2b1","annotation":"SH2B adapter protein 1; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphoryla [...] "},{"id":"ENSMUSP00000028137","abundance":3.92,"rank":6337,"name":"Coq4","annotation":"Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family."},{"id":"ENSMUSP00000107381","abundance":3.92,"rank":6338,"name":"Cux2","annotation":"Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner. Belongs to the CUT homeobox family."},{"id":"ENSMUSP00000124872","abundance":3.92,"rank":6339,"name":"Sphkap","annotation":"A-kinase anchor protein SPHKAP; Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1 (By similarity)."},{"id":"ENSMUSP00000079937","abundance":3.91,"rank":6340,"name":"Sgcb","annotation":"Beta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix."},{"id":"ENSMUSP00000024805","abundance":3.91,"rank":6341,"name":"Cpne5","annotation":"Copine-5; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes. Belongs to the copine family."},{"id":"ENSMUSP00000032454","abundance":3.91,"rank":6342,"name":"Slc6a1","annotation":"Sodium- and chloride-dependent GABA transporter 1; Terminates the action of GABA by its high affinity sodium- dependent reuptake into presynaptic terminals; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily."},{"id":"ENSMUSP00000095174","abundance":3.91,"rank":6343,"name":"Synpo","annotation":"Synaptopodin; Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity."},{"id":"ENSMUSP00000020564","abundance":3.91,"rank":6344,"name":"Shc2","annotation":"SHC-transforming protein 2; Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons."},{"id":"ENSMUSP00000102846","abundance":3.9,"rank":6345,"name":"Tmod4","annotation":"Tropomodulin-4; Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity)."},{"id":"ENSMUSP00000045456","abundance":3.9,"rank":6346,"name":"Ssr2","annotation":"Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins."},{"id":"ENSMUSP00000034905","abundance":3.89,"rank":6347,"name":"Gclc","annotation":"Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family."},{"id":"ENSMUSP00000110941","abundance":3.89,"rank":6348,"name":"Fam71f2","annotation":"Family with sequence similarity 71, member F2."},{"id":"ENSMUSP00000019118","abundance":3.89,"rank":6349,"name":"Sart3","annotation":"Squamous cell carcinoma antigen recognized by T-cells 3; U6 snRNP-binding protein that functions as a recycling factor of the splicing machinery. Promotes the initial reassembly of U4 and U6 snRNPs following their ejection from the spliceosome during its maturation. Also binds U6atac snRNPs and may function as a recycling factor for U4atac/U6atac spliceosomal snRNP, an initial step in the assembly of U12-type spliceosomal complex. The U12-type spliceosomal complex plays a role in the splicing of introns with non-canonical splice sites. May also function as a substrate-targeting factor  [...] "},{"id":"ENSMUSP00000140870","abundance":3.89,"rank":6350,"name":"Cabyr","annotation":"Calcium-binding tyrosine phosphorylation-regulated protein; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity)."},{"id":"ENSMUSP00000097743","abundance":3.89,"rank":6351,"name":"Abcc1","annotation":"Multidrug resistance-associated protein 1; Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o- glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (By similarity). Participates in [...] "},{"id":"ENSMUSP00000042211","abundance":3.89,"rank":6352,"name":"Sema7a","annotation":"Semaphorin-7A; Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes."},{"id":"ENSMUSP00000027303","abundance":3.89,"rank":6353,"name":"Imp4","annotation":"U3 small nucleolar ribonucleoprotein protein IMP4; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (By similarity)."},{"id":"ENSMUSP00000103412","abundance":3.89,"rank":6354,"name":"Stra6l","annotation":"Stimulated by retinoic acid gene 6 protein-like; Acts as a high-affinity cell-surface receptor for retinol- binding protein RBP4 and mediates RBP4-dependent retinol uptake in the liver."},{"id":"ENSMUSP00000098411","abundance":3.89,"rank":6355,"name":"1500011B03Rik","annotation":"RIKEN cDNA 1500011B03 gene."},{"id":"ENSMUSP00000034272","abundance":3.88,"rank":6356,"name":"Mvb12a","annotation":"Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor (By similarity); Belongs to the MVB12 family."},{"id":"ENSMUSP00000068192","abundance":3.88,"rank":6357,"name":"Zfp608","annotation":"Zinc finger protein 608; Transcription factor, which represses ZNF609 transcription."},{"id":"ENSMUSP00000024738","abundance":3.88,"rank":6358,"name":"Sult1c1","annotation":"Sulfotransferase 1C1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters. May be involved in the activation of carcinogenic hydroxylamines. Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). Also shows activity towards cinnamyl alcohol at pH 6.4 but not at pH 5.5, and towards a number of phenolic odorants including eugenol, guaiacol and 2-naphthol."},{"id":"ENSMUSP00000024599","abundance":3.88,"rank":6359,"name":"Igf2r","annotation":"Cation-independent mannose-6-phosphate receptor; Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2; Belongs to the MRL1/IGF2R family."},{"id":"ENSMUSP00000140268","abundance":3.88,"rank":6360,"name":"Smpx","annotation":"Small muscular protein; Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair; Belongs to the SMPX family."},{"id":"ENSMUSP00000038580","abundance":3.88,"rank":6361,"name":"Rrp9","annotation":"U3 small nucleolar RNA-interacting protein 2; Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA)."},{"id":"ENSMUSP00000045288","abundance":3.88,"rank":6362,"name":"4930505A04Rik","annotation":"Uncharacterized protein C2orf73 homolog."},{"id":"ENSMUSP00000089703","abundance":3.88,"rank":6363,"name":"Lama3","annotation":"Laminin subunit alpha-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."},{"id":"ENSMUSP00000101851","abundance":3.88,"rank":6364,"name":"Endov","annotation":"Endonuclease V; Endoribonuclease that specifically cleaves inosine-containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double- stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'-UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved [...] "},{"id":"ENSMUSP00000037628","abundance":3.87,"rank":6365,"name":"Kdm3b","annotation":"Lysine-specific demethylase 3B; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate May have tumor suppressor activity (By similarity)."},{"id":"ENSMUSP00000058723","abundance":3.87,"rank":6366,"name":"Tmed3","annotation":"Transmembrane emp24 domain-containing protein 3; Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network (By similarity)."},{"id":"ENSMUSP00000030487","abundance":3.87,"rank":6367,"name":"Cyp4a14","annotation":"Cytochrome P450 4A14; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of saturated carbon hydrogen bonds of fatty acids. May act as a major omega- and ommega-1 hydroxylase for dodecanoic (lauric) acid in kidney. Catalyzes with low efficiency the epoxidation of 11,12-double bond of arachidonic acid."},{"id":"ENSMUSP00000048262","abundance":3.87,"rank":6368,"name":"Mnd1","annotation":"Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double- strand breaks."},{"id":"ENSMUSP00000091889","abundance":3.87,"rank":6369,"name":"Nsmce3","annotation":"Non-structural maintenance of chromosomes element 3 homolog; Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML b [...] "},{"id":"ENSMUSP00000105979","abundance":3.87,"rank":6370,"name":"Prl8a8","annotation":"Prolactin-8A8; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000047260","abundance":3.87,"rank":6371,"name":"Fmnl2","annotation":"Formin-like protein 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics (By similarity); Belongs to the formin homology family."},{"id":"ENSMUSP00000111463","abundance":3.87,"rank":6372,"name":"Arid1b","annotation":"AT-rich interactive domain-containing protein 1B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/ [...] "},{"id":"ENSMUSP00000156593","abundance":3.86,"rank":6373,"name":"Mea1","annotation":"Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development."},{"id":"ENSMUSP00000043355","abundance":3.86,"rank":6374,"name":"Rmnd1","annotation":"Required for meiotic nuclear division protein 1 homolog; Required for mitochondrial translation, possibly by coordinating the assembly or maintenance of the mitochondrial ribosome."},{"id":"ENSMUSP00000023869","abundance":3.86,"rank":6375,"name":"Denr","annotation":"Density-regulated protein; May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity); Belongs to the DENR family."},{"id":"ENSMUSP00000022977","abundance":3.86,"rank":6376,"name":"Sqle","annotation":"Squalene monooxygenase; Catalyzes the stereospecific oxidation of squalene to (S)- 2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis."},{"id":"ENSMUSP00000068661","abundance":3.86,"rank":6377,"name":"Mdm4","annotation":"Protein Mdm4; Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. The short isoform is a more potent inhibitor of TP53 activity than the long isoform."},{"id":"ENSMUSP00000121390","abundance":3.85,"rank":6378,"name":"Epn3","annotation":"Epsin-3; Belongs to the epsin family."},{"id":"ENSMUSP00000007865","abundance":3.85,"rank":6379,"name":"Ccdc124","annotation":"Coiled-coil domain-containing protein 124; Required for proper progression of late cytokinetic stages."},{"id":"ENSMUSP00000137043","abundance":3.85,"rank":6380,"name":"H2al1k","annotation":"Histone H2A; Belongs to the histone H2A family."},{"id":"ENSMUSP00000136794","abundance":3.85,"rank":6381,"name":"H2al1h","annotation":"H2A histone family member L1H."},{"id":"ENSMUSP00000073605","abundance":3.85,"rank":6382,"name":"H2al1m","annotation":"Histone H2A; Belongs to the histone H2A family."},{"id":"ENSMUSP00000135929","abundance":3.85,"rank":6383,"name":"H2al1c","annotation":"H2A histone family member L1C."},{"id":"ENSMUSP00000137575","abundance":3.85,"rank":6384,"name":"H2al1g","annotation":"H2A histone family member L1G."},{"id":"ENSMUSP00000140925","abundance":3.85,"rank":6385,"name":"H2al1a","annotation":"H2A histone family member L1A."},{"id":"ENSMUSP00000136763","abundance":3.85,"rank":6386,"name":"H2al1e","annotation":"Histone H2A; Belongs to the histone H2A family."},{"id":"ENSMUSP00000136695","abundance":3.85,"rank":6387,"name":"H2al1f","annotation":"H2A histone family member L1F."},{"id":"ENSMUSP00000137030","abundance":3.85,"rank":6388,"name":"H2al1d","annotation":"H2A histone family member L1D."},{"id":"ENSMUSP00000125841","abundance":3.85,"rank":6389,"name":"H2al1i","annotation":"Histone H2A-like 1; Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling."},{"id":"ENSMUSP00000060613","abundance":3.84,"rank":6390,"name":"Wdr3","annotation":"WD repeat-containing protein 3."},{"id":"ENSMUSP00000084414","abundance":3.84,"rank":6391,"name":"Gemin8","annotation":"Gem-associated protein 8; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...] "},{"id":"ENSMUSP00000025411","abundance":3.84,"rank":6392,"name":"Prelid3a","annotation":"PRELI domain containing protein 3A; In vitro, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space. Phosphatidic acid import is required for cardiolipin (CL) synthesis in the mitochondrial inner membrane."},{"id":"ENSMUSP00000001757","abundance":3.84,"rank":6393,"name":"Eef1e1","annotation":"Eukaryotic translation elongation factor 1 epsilon-1; Positive modulator of ATM response to DNA damage."},{"id":"ENSMUSP00000056792","abundance":3.84,"rank":6394,"name":"Tmem259","annotation":"Membralin; May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. Belongs to the membralin family."},{"id":"ENSMUSP00000005452","abundance":3.84,"rank":6395,"name":"Fgfr4","annotation":"Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] "},{"id":"ENSMUSP00000001166","abundance":3.84,"rank":6396,"name":"Cnnm3","annotation":"Metal transporter CNNM3; Probable metal transporter."},{"id":"ENSMUSP00000104795","abundance":3.84,"rank":6397,"name":"Aida","annotation":"Axin interactor, dorsalization-associated protein; Acts as a ventralizing factor during embryogenesis (By similarity). Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta- catenin-independent dorsalization pathway activated by AXIN/JNK- signaling."},{"id":"ENSMUSP00000092019","abundance":3.83,"rank":6398,"name":"Id1","annotation":"DNA-binding protein inhibitor ID-1; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] "},{"id":"ENSMUSP00000029603","abundance":3.83,"rank":6399,"name":"Prss12","annotation":"Neurotrypsin; Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations."},{"id":"ENSMUSP00000047402","abundance":3.83,"rank":6400,"name":"Apobec2","annotation":"C->U-editing enzyme APOBEC-2; Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation."},{"id":"ENSMUSP00000150823","abundance":3.83,"rank":6401,"name":"Thyn1","annotation":"Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC."},{"id":"ENSMUSP00000053672","abundance":3.83,"rank":6402,"name":"Pygo2","annotation":"Pygopus 2."},{"id":"ENSMUSP00000114844","abundance":3.83,"rank":6403,"name":"Sap30bp","annotation":"SAP30-binding protein; Induces cell death. May act as a transcriptional corepressor of a gene related to cell survival (By similarity). May be involved in the regulation of beta-2-microglobulin genes."},{"id":"ENSMUSP00000108948","abundance":3.83,"rank":6404,"name":"Foxp1","annotation":"Forkhead box protein P1; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neur [...] "},{"id":"ENSMUSP00000103881","abundance":3.83,"rank":6405,"name":"Wwp1","annotation":"NEDD4-like E3 ubiquitin-protein ligase WWP1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF (By similarity). Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR [...] "},{"id":"ENSMUSP00000101759","abundance":3.83,"rank":6406,"name":"Ssx2ip","annotation":"Afadin- and alpha-actinin-binding protein; Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin- catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha- actinin. Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in [...] "},{"id":"ENSMUSP00000122072","abundance":3.83,"rank":6407,"name":"Ramp2","annotation":"Receptor activity-modifying protein 2; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family."},{"id":"ENSMUSP00000113641","abundance":3.83,"rank":6408,"name":"Ifitm7","annotation":"Interferon-induced transmembrane protein 7."},{"id":"ENSMUSP00000142149","abundance":3.83,"rank":6409,"name":"Tgfb2","annotation":"Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] "},{"id":"ENSMUSP00000048084","abundance":3.83,"rank":6410,"name":"Nup133","annotation":"Nuclear pore complex protein Nup133; Involved in poly(A)+ RNA transport. Involved in nephrogenesis."},{"id":"ENSMUSP00000080846","abundance":3.83,"rank":6411,"name":"Cyp2b9","annotation":"Cytochrome P450 2B9; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000099329","abundance":3.82,"rank":6412,"name":"Nat9","annotation":"N-acetyltransferase 9; Belongs to the acetyltransferase family. GNAT subfamily."},{"id":"ENSMUSP00000043193","abundance":3.82,"rank":6413,"name":"Fkbp6","annotation":"Inactive peptidyl-prolyl cis-trans isomerase FKBP6; Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be re [...] "},{"id":"ENSMUSP00000022517","abundance":3.82,"rank":6414,"name":"Cryl1","annotation":"Lambda-crystallin homolog; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family."},{"id":"ENSMUSP00000109027","abundance":3.82,"rank":6415,"name":"Swi5","annotation":"DNA repair protein SWI5 homolog; Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Belongs to the SWI5/SAE3 family."},{"id":"ENSMUSP00000130758","abundance":3.82,"rank":6416,"name":"Luzp1","annotation":"Leucine zipper protein 1."},{"id":"ENSMUSP00000010241","abundance":3.82,"rank":6417,"name":"Nxf1","annotation":"Nuclear RNA export factor 1; Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1- NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A- containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A- containing mRNA-binding to both [...] "},{"id":"ENSMUSP00000063468","abundance":3.81,"rank":6418,"name":"Ncam2","annotation":"Neural cell adhesion molecule 2; May play important roles in selective fasciculation and zone- to-zone projection of the primary olfactory axons."},{"id":"ENSMUSP00000136644","abundance":3.81,"rank":6419,"name":"Aamp","annotation":"Angio-associated migratory protein."},{"id":"ENSMUSP00000029700","abundance":3.81,"rank":6420,"name":"Sema4a","annotation":"Semaphorin-4A; Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits [...] "},{"id":"ENSMUSP00000058718","abundance":3.8,"rank":6421,"name":"Mypop","annotation":"Myb-related transcription factor, partner of profilin; Transcriptional repressor; DNA-binding protein that specifically recognizes the core sequence 5'-YAAC[GT]G-3'. Dimerization with PFN1 reduces its DNA-binding capacity."},{"id":"ENSMUSP00000022993","abundance":3.8,"rank":6422,"name":"Derl1","annotation":"Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre- emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for pro [...] "},{"id":"ENSMUSP00000060835","abundance":3.8,"rank":6423,"name":"Gchfr","annotation":"GTP cyclohydrolase 1 feedback regulatory protein; Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine (By similarity)."},{"id":"ENSMUSP00000034239","abundance":3.8,"rank":6424,"name":"Katnb1","annotation":"Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The  [...] "},{"id":"ENSMUSP00000017692","abundance":3.8,"rank":6425,"name":"Suz12","annotation":"Polycomb protein Suz12; Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED- EZH2 complex include HOXA7, HOXB6 and HOXC8. Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family."},{"id":"ENSMUSP00000079991","abundance":3.79,"rank":6426,"name":"Plcg2","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity)."},{"id":"ENSMUSP00000051644","abundance":3.79,"rank":6427,"name":"Mblac2","annotation":"Metallo-beta-lactamase domain-containing protein 2."},{"id":"ENSMUSP00000122420","abundance":3.79,"rank":6428,"name":"Cdc23","annotation":"Cell division cycle protein 23 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)."},{"id":"ENSMUSP00000016897","abundance":3.79,"rank":6429,"name":"Ttll1","annotation":"Probable tubulin polyglutamylase TTLL1; Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin."},{"id":"ENSMUSP00000029374","abundance":3.79,"rank":6430,"name":"Nbea","annotation":"Neurobeachin; Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. May have a role in membrane trafficking."},{"id":"ENSMUSP00000045460","abundance":3.78,"rank":6431,"name":"Psme4","annotation":"Proteasome activator complex subunit 4; Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating  [...] "},{"id":"ENSMUSP00000034022","abundance":3.78,"rank":6432,"name":"Sap30","annotation":"Histone deacetylase complex subunit SAP30; Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones; Belongs to the SAP30 family."},{"id":"ENSMUSP00000022693","abundance":3.78,"rank":6433,"name":"Bmp1","annotation":"Bone morphogenetic protein 1; Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD) (By similarity). Responsible for the proteolytic activation of lysyl oxidase LOX."},{"id":"ENSMUSP00000110564","abundance":3.78,"rank":6434,"name":"Enox2","annotation":"Protein disulfide-thiol oxidoreductase; May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock (By similarity). Belongs to the ENOX family."},{"id":"ENSMUSP00000099986","abundance":3.78,"rank":6435,"name":"Pold2","annotation":"DNA polymerase delta subunit 2; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Pol-delta3 and Pol- delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4. Although both Pol- delta3 and  [...] "},{"id":"ENSMUSP00000099360","abundance":3.78,"rank":6436,"name":"Gh","annotation":"Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000046748","abundance":3.78,"rank":6437,"name":"Cplx3","annotation":"Complexin-3; Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion. Required for the maintenance of synaptic ultrastructure in the adult retina. Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina. Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release."},{"id":"ENSMUSP00000025488","abundance":3.77,"rank":6438,"name":"C330018D20Rik","annotation":"Glutaredoxin-like protein C5orf63 homolog; Belongs to the glutaredoxin family. YDR286C subfamily."},{"id":"ENSMUSP00000050372","abundance":3.77,"rank":6439,"name":"Selenov","annotation":"Selenoprotein V."},{"id":"ENSMUSP00000028549","abundance":3.77,"rank":6440,"name":"Slc12a6","annotation":"Solute carrier family 12 member 6; Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells; Belongs to the SLC12A transporter family."},{"id":"ENSMUSP00000025170","abundance":3.77,"rank":6441,"name":"Wdr46","annotation":"WD repeat-containing protein 46; Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus."},{"id":"ENSMUSP00000084489","abundance":3.77,"rank":6442,"name":"Cyp2c65","annotation":"Cytochrome P450, family 2, subfamily c, polypeptide 65; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000022861","abundance":3.77,"rank":6443,"name":"Ugt3a1","annotation":"UDP-glucuronosyltransferase 3A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000006136","abundance":3.77,"rank":6444,"name":"Dnase1","annotation":"Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs. Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intravascular NETs by [...] "},{"id":"ENSMUSP00000151356","abundance":3.77,"rank":6445,"name":"Olfr640","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000055969","abundance":3.77,"rank":6446,"name":"Parn","annotation":"Poly(A)-specific ribonuclease PARN; 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsens [...] "},{"id":"ENSMUSP00000025253","abundance":3.77,"rank":6447,"name":"Prrc2a","annotation":"Protein PRRC2A; May play a role in the regulation of pre-mRNA splicing."},{"id":"ENSMUSP00000051468","abundance":3.77,"rank":6448,"name":"Plekha4","annotation":"Pleckstrin homology domain-containing family A member 4; Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides."},{"id":"ENSMUSP00000103935","abundance":3.77,"rank":6449,"name":"Ect2","annotation":"Protein ECT2; Guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP. Promotes guanine nucleotide exchange on the Rho family members of small GTPases, like RHOA, RHOC, RAC1 and CDC42. Required for signal transduction pathways involved in the regulation of cytokinesis. Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Regulates the translocation of RHOA from the central spindle to the equatorial region. Plays a role i [...] "},{"id":"ENSMUSP00000009435","abundance":3.77,"rank":6450,"name":"Pttg1ip","annotation":"Pituitary tumor-transforming gene 1 protein-interacting protein; May facilitate PTTG1 nuclear translocation."},{"id":"ENSMUSP00000146244","abundance":3.76,"rank":6451,"name":"Cbl","annotation":"E3 ubiquitin-protein ligase CBL; Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family [...] "},{"id":"ENSMUSP00000093970","abundance":3.76,"rank":6452,"name":"1810009A15Rik","annotation":"Uncharacterized protein C11orf98 homolog."},{"id":"ENSMUSP00000088031","abundance":3.76,"rank":6453,"name":"Nr1d2","annotation":"Nuclear receptor subfamily 1 group D member 2; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components ARNTL/BMAL1 and CLOCK. Also regulates genes involved in metabolic functions, including lipid metabolism and the inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 co [...] "},{"id":"ENSMUSP00000036774","abundance":3.76,"rank":6454,"name":"Slc45a1","annotation":"Proton-associated sugar transporter A; Proton-associated glucose transporter in the brain. Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family."},{"id":"ENSMUSP00000147154","abundance":3.76,"rank":6455,"name":"Zfp78","annotation":"Zinc finger protein 78."},{"id":"ENSMUSP00000000028","abundance":3.76,"rank":6456,"name":"Cdc45","annotation":"Cell division control protein 45 homolog; Required for initiation of chromosomal DNA replication; Belongs to the CDC45 family."},{"id":"ENSMUSP00000002699","abundance":3.76,"rank":6457,"name":"Akap8","annotation":"A-kinase anchor protein 8; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (By similarity). Specifically involved in recruitment of CAPD2 to, and condensation of maternal but not paternal chromosomes. May help to d [...] "},{"id":"ENSMUSP00000070915","abundance":3.76,"rank":6458,"name":"Snx32","annotation":"Sorting nexin-32; May be involved in several stages of intracellular trafficking."},{"id":"ENSMUSP00000013970","abundance":3.75,"rank":6459,"name":"Pip4k2c","annotation":"Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma; May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum."},{"id":"ENSMUSP00000149005","abundance":3.75,"rank":6460,"name":"Olfr433","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000129922","abundance":3.75,"rank":6461,"name":"Tfap2c","annotation":"Transcription factor AP-2 gamma; Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC."},{"id":"ENSMUSP00000053751","abundance":3.75,"rank":6462,"name":"Sprr1a","annotation":"Cornifin-A; Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. May participate widely in the construction of cell envelopes in cornifying epithelia characterized by either increased thickness or a requirement for extreme flexibility; Belongs to the cornifin (SPRR) family."},{"id":"ENSMUSP00000144944","abundance":3.75,"rank":6463,"name":"Olfr315","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000101146","abundance":3.75,"rank":6464,"name":"Ppil6","annotation":"Probable inactive peptidyl-prolyl cis-trans isomerase-like 6; Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity."},{"id":"ENSMUSP00000095595","abundance":3.75,"rank":6465,"name":"Cdkn2b","annotation":"Cyclin-dependent kinase 4 inhibitor B; Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (By similarity); Belongs to the CDKN2 cyclin-dependent kinase inhibitor family."},{"id":"ENSMUSP00000080214","abundance":3.74,"rank":6466,"name":"Ltbp3","annotation":"Latent-transforming growth factor beta-binding protein 3; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta."},{"id":"ENSMUSP00000099718","abundance":3.74,"rank":6467,"name":"Itga4","annotation":"Integrin alpha-4; Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha-4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-ce [...] "},{"id":"ENSMUSP00000073976","abundance":3.74,"rank":6468,"name":"Irx2","annotation":"Iroquois-class homeodomain protein IRX-2."},{"id":"ENSMUSP00000048183","abundance":3.74,"rank":6469,"name":"Capn5","annotation":"Calpain-5; Calcium-regulated non-lysosomal thiol-protease."},{"id":"ENSMUSP00000023460","abundance":3.74,"rank":6470,"name":"Ncbp2","annotation":"Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The C [...] "},{"id":"ENSMUSP00000076383","abundance":3.74,"rank":6471,"name":"Sftpd","annotation":"Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties; Belongs to the SFTPD family."},{"id":"ENSMUSP00000039394","abundance":3.73,"rank":6472,"name":"Bicd2","annotation":"Protein bicaudal D homolog 2; Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates and stabilizes the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Facilitates the binding of RAB6A to the Golgi by stabilizing its GTP-bound form. Regulates coat complex coatomer protein I (COPI)- independent Golgi-endoplasmic reticulum transport via i [...] "},{"id":"ENSMUSP00000118333","abundance":3.73,"rank":6473,"name":"Ube2j1","annotation":"Ubiquitin-conjugating enzyme E2 J1; Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD); Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000049563","abundance":3.73,"rank":6474,"name":"Bsnd","annotation":"Barttin; Functions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter."},{"id":"ENSMUSP00000042265","abundance":3.73,"rank":6475,"name":"Gtf3c4","annotation":"General transcription factor 3C polypeptide 4; Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus- associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box (By similarity)."},{"id":"ENSMUSP00000066736","abundance":3.73,"rank":6476,"name":"Ppp6r1","annotation":"Serine/threonine-protein phosphatase 6 regulatory subunit 1; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha (By similarity); Belongs to the SAPS family."},{"id":"ENSMUSP00000021116","abundance":3.72,"rank":6477,"name":"Unk","annotation":"RING finger protein unkempt homolog; Sequence-specific RNA-binding protein which plays an important role in the establishment and maintenance of the early morphology of cortical neurons during embryonic development. Acts as a translation repressor and controls a translationally regulated cell morphology program to ensure proper structuring of the nervous system. Translational control depends on recognition of its binding element within target mRNAs which consists of a mandatory UAG trimer upstream of a U/A-rich motif. Associated with polysomes. Belongs to the unkempt family."},{"id":"ENSMUSP00000102131","abundance":3.72,"rank":6478,"name":"Tex38","annotation":"Testis-expressed protein 38."},{"id":"ENSMUSP00000053678","abundance":3.72,"rank":6479,"name":"Hexim2","annotation":"Protein HEXIM2; Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity); Belongs to the HEXIM family."},{"id":"ENSMUSP00000115822","abundance":3.72,"rank":6480,"name":"Fam129a","annotation":"Protein Niban 1; Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response."},{"id":"ENSMUSP00000023861","abundance":3.72,"rank":6481,"name":"Serpinb3d","annotation":"Serine (Or cysteine) peptidase inhibitor, clade B (Ovalbumin), member 3D; Belongs to the serpin family."},{"id":"ENSMUSP00000025092","abundance":3.72,"rank":6482,"name":"Tmem178","annotation":"Transmembrane protein 178A; Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1."},{"id":"ENSMUSP00000071786","abundance":3.71,"rank":6483,"name":"Car12","annotation":"Carbonic anhydrase 12; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family."},{"id":"ENSMUSP00000143341","abundance":3.71,"rank":6484,"name":"Csn2","annotation":"Beta-casein; Important role in determination of the surface properties of the casein micelles."},{"id":"ENSMUSP00000068775","abundance":3.71,"rank":6485,"name":"E130116L18Rik","annotation":"RIKEN cDNA E130116L18 gene."},{"id":"ENSMUSP00000090511","abundance":3.71,"rank":6486,"name":"Wfdc17","annotation":"Activated macrophage/microglia WAP domain protein."},{"id":"ENSMUSP00000095051","abundance":3.71,"rank":6487,"name":"Ptpn14","annotation":"Tyrosine-protein phosphatase non-receptor type 14; Protein tyrosine phosphatase which may play a role in the regulation of lymphangiogenesis, cell-cell adhesion, cell-matrix adhesion, cell migration, cell growth and also regulates TGF-beta gene expression, thereby modulating epithelial-mesenchymal transition. Mediates beta-catenin dephosphorylation at adhesion junctions. Acts as a negative regulator of the oncogenic property of YAP, a downstream target of the hippo pathway, in a cell density-dependent manner. May function as a tumor suppressor."},{"id":"ENSMUSP00000099073","abundance":3.71,"rank":6488,"name":"Ptn","annotation":"Pleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors (By similarity). Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups (By similarity). Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone. Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation. Binds PTPRZ1, leading to neutralization of the negative char [...] "},{"id":"ENSMUSP00000076922","abundance":3.71,"rank":6489,"name":"Slc9a6","annotation":"Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family."},{"id":"ENSMUSP00000023112","abundance":3.71,"rank":6490,"name":"Pmm1","annotation":"Phosphomannomutase 1; Involved in the synthesis of the GDP-mannose and dolichol- phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain."},{"id":"ENSMUSP00000096185","abundance":3.7,"rank":6491,"name":"Sdhaf1","annotation":"Succinate dehydrogenase assembly factor 1, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDH [...] "},{"id":"ENSMUSP00000019876","abundance":3.7,"rank":6492,"name":"Calr3","annotation":"Calreticulin-3; CALR3 capacity for calcium-binding may be absent or much lower than that of CALR (By similarity). During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility."},{"id":"ENSMUSP00000133280","abundance":3.7,"rank":6493,"name":"Xpo4","annotation":"Exportin-4; Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate ano [...] "},{"id":"ENSMUSP00000000985","abundance":3.7,"rank":6494,"name":"Oxa1l","annotation":"Mitochondrial inner membrane protein OXA1L; Required for the insertion of integral membrane proteins into the mitochondrial inner membrane. Essential for the activity and assembly of cytochrome oxidase. Required for the correct biogenesis of ATP synthase and complex I in mitochondria (By similarity)."},{"id":"ENSMUSP00000075692","abundance":3.7,"rank":6495,"name":"Tspan7","annotation":"Tetraspanin-7; May be involved in cell proliferation and cell motility; Belongs to the tetraspanin (TM4SF) family."},{"id":"ENSMUSP00000119939","abundance":3.69,"rank":6496,"name":"Uxs1","annotation":"UDP-glucuronic acid decarboxylase 1; Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis (By similarity). Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily."},{"id":"ENSMUSP00000055779","abundance":3.69,"rank":6497,"name":"Klre1","annotation":"Killer cell lectin-like receptor subfamily E member 1; Lectin-like receptor for natural killer (NK) cells. Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner. Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation. Plays a role in allogeneic recognition by the immune system."},{"id":"ENSMUSP00000105590","abundance":3.69,"rank":6498,"name":"Foxa2","annotation":"Hepatocyte nuclear factor 3-beta; Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'- [AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Inv [...] "},{"id":"ENSMUSP00000053810","abundance":3.69,"rank":6499,"name":"Krtap4-13","annotation":"Keratin associated protein 4-13."},{"id":"ENSMUSP00000001818","abundance":3.68,"rank":6500,"name":"Crnkl1","annotation":"Crooked neck-like protein 1; Involved in pre-mRNA splicing process."},{"id":"ENSMUSP00000017153","abundance":3.68,"rank":6501,"name":"Sdc4","annotation":"Syndecan-4; Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP. Belongs to the syndecan proteoglycan family."},{"id":"ENSMUSP00000019962","abundance":3.68,"rank":6502,"name":"Cd164","annotation":"Sialomucin core protein 24; Sialomucin that may play a key role in hematopoiesis. May be involved in cell adhesion (By similarity). Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes. Belongs to the CD164 family."},{"id":"ENSMUSP00000115881","abundance":3.68,"rank":6503,"name":"Psmg4","annotation":"Proteasome assembly chaperone 4; Chaperone protein which promotes assembly of the 20S proteasome; Belongs to the PSMG4 family."},{"id":"ENSMUSP00000136768","abundance":3.68,"rank":6504,"name":"Eif4enif1","annotation":"Eukaryotic translation initiation factor 4E transporter; Nucleoplasmic shuttling protein, which inhibits translation initiation. Mediates the nuclear import of EIF4E by a piggy-back mechanism."},{"id":"ENSMUSP00000032257","abundance":3.68,"rank":6505,"name":"Klrb1f","annotation":"Killer cell lectin-like receptor subfamily B member 1F; Binds CLEC2I/Clr-g leading to activation of natural killer cells or costimulation of IL-2 production and proliferation of T-cells in response to antigen stimulation. May contribute to the formation of the immunological synapse between T-cells and antigen-presenting dendritic cells."},{"id":"ENSMUSP00000150843","abundance":3.67,"rank":6506,"name":"Slc37a4","annotation":"Solute carrier family 37 (Glucose-6-phosphate transporter), member 4."},{"id":"ENSMUSP00000031678","abundance":3.67,"rank":6507,"name":"Tspan12","annotation":"Tetraspanin-12; Regulator of cell surface receptor signal transduction. Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1- MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transc [...] "},{"id":"ENSMUSP00000025406","abundance":3.67,"rank":6508,"name":"Srfbp1","annotation":"Serum response factor-binding protein 1; May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells."},{"id":"ENSMUSP00000123509","abundance":3.67,"rank":6509,"name":"Tnni1","annotation":"Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity."},{"id":"ENSMUSP00000125255","abundance":3.67,"rank":6510,"name":"Cabp2","annotation":"Calcium-binding protein 2; Required for sound encoding at inner hair cells (IHCs) synapses, likely via inhibition of the inactivation of voltage-gated calcium channel of type 1.3 (Cav1.3) in the IHCs. Required for the normal transfer of light signals through the retina."},{"id":"ENSMUSP00000032709","abundance":3.67,"rank":6511,"name":"Kctd15","annotation":"BTB/POZ domain-containing protein KCTD15; During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity)."},{"id":"ENSMUSP00000042391","abundance":3.66,"rank":6512,"name":"Traf3ip1","annotation":"TRAF3-interacting protein 1; Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules (By similarity). Involved in epithelial morphogenesis and in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis ; Belongs to the TRAF3IP1 family."},{"id":"ENSMUSP00000019065","abundance":3.66,"rank":6513,"name":"Pelp1","annotation":"Proline-, glutamic acid- and leucine-rich protein 1; Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/g [...] "},{"id":"ENSMUSP00000033310","abundance":3.66,"rank":6514,"name":"Mki67","annotation":"Proliferation marker protein Ki-67; Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for s [...] "},{"id":"ENSMUSP00000076012","abundance":3.66,"rank":6515,"name":"Slc39a1","annotation":"Zinc transporter ZIP1; Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body (By similarity). Belongs to the ZIP transporter (TC 2.A.5) family."},{"id":"ENSMUSP00000048079","abundance":3.66,"rank":6516,"name":"Gdf5","annotation":"Growth/differentiation factor 5; Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity). Required to p [...] "},{"id":"ENSMUSP00000111137","abundance":3.66,"rank":6517,"name":"Foxp2","annotation":"Forkhead box protein P2; Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels."},{"id":"ENSMUSP00000072512","abundance":3.66,"rank":6518,"name":"Ms4a4c","annotation":"Membrane-spanning 4-domains, subfamily A, member 4C."},{"id":"ENSMUSP00000143853","abundance":3.66,"rank":6519,"name":"Specc1","annotation":"Cytospin-B."},{"id":"ENSMUSP00000038418","abundance":3.65,"rank":6520,"name":"Ints8","annotation":"Integrator complex subunit 8; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity)."},{"id":"ENSMUSP00000133064","abundance":3.65,"rank":6521,"name":"Fgfr3","annotation":"Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] "},{"id":"ENSMUSP00000029569","abundance":3.65,"rank":6522,"name":"Slc35a3","annotation":"UDP-N-acetylglucosamine transporter; Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter in the Golgi apparatus. May supply UDP-GlcNAc as substrate for Golgi-resident glycosyltransferases that generate branching of diantennary oligosaccharides (By similarity)."},{"id":"ENSMUSP00000095739","abundance":3.65,"rank":6523,"name":"Rbmxl2","annotation":"RNA-binding motif protein, X-linked-like 2."},{"id":"ENSMUSP00000002456","abundance":3.65,"rank":6524,"name":"Nt5c1b","annotation":"Cytosolic 5'-nucleotidase 1B; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels."},{"id":"ENSMUSP00000098041","abundance":3.65,"rank":6525,"name":"Kif13b","annotation":"Kinesin family member 13B."},{"id":"ENSMUSP00000022913","abundance":3.65,"rank":6526,"name":"Dcstamp","annotation":"Dendritic cell-specific transmembrane protein; Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. I [...] "},{"id":"ENSMUSP00000023061","abundance":3.65,"rank":6527,"name":"Josd1","annotation":"Josephin-1; Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly- ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity)."},{"id":"ENSMUSP00000065511","abundance":3.64,"rank":6528,"name":"Rgs9bp","annotation":"Regulator of G-protein signaling 9-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protectin [...] "},{"id":"ENSMUSP00000112719","abundance":3.64,"rank":6529,"name":"Wdr31","annotation":"WD repeat-containing protein 31."},{"id":"ENSMUSP00000110965","abundance":3.64,"rank":6530,"name":"Trp63","annotation":"Tumor protein 63; Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the  [...] "},{"id":"ENSMUSP00000061423","abundance":3.64,"rank":6531,"name":"Susd3","annotation":"Sushi domain-containing protein 3."},{"id":"ENSMUSP00000105358","abundance":3.64,"rank":6532,"name":"Rnaseh2a","annotation":"Ribonuclease H2 subunit A; Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes."},{"id":"ENSMUSP00000124819","abundance":3.63,"rank":6533,"name":"Commd2","annotation":"COMM domain-containing protein 2; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B."},{"id":"ENSMUSP00000105272","abundance":3.63,"rank":6534,"name":"Vstm2a","annotation":"V-set and transmembrane domain-containing protein 2A; Plays a role in the regulation of the early stage of white and brown preadipocyte cell differentiation. Promotes adipogenic commitment of preadipocytes by increasing gene expression of the transcription factor PPARG in a BMP4-dependent signaling pathway."},{"id":"ENSMUSP00000021885","abundance":3.63,"rank":6535,"name":"Tpbpa","annotation":"Trophoblast-specific protein alpha; It may be a growth factor/hormone, perhaps involved in interaction between the maternal and fetal systems in maintenance of pregnancy."},{"id":"ENSMUSP00000024857","abundance":3.63,"rank":6536,"name":"Lbh","annotation":"Protein LBH; Modulates the activity of key transcription factors involved in cardiogenesis."},{"id":"ENSMUSP00000031215","abundance":3.63,"rank":6537,"name":"Brdt","annotation":"Bromodomain testis-specific protein; Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also re [...] "},{"id":"ENSMUSP00000044834","abundance":3.63,"rank":6538,"name":"Arhgap18","annotation":"Rho GTPase-activating protein 18; Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration (By similarity)."},{"id":"ENSMUSP00000084423","abundance":3.63,"rank":6539,"name":"Lrrc66","annotation":"Leucine-rich repeat-containing protein 66."},{"id":"ENSMUSP00000091641","abundance":3.63,"rank":6540,"name":"Tmem41b","annotation":"Transmembrane protein 41B; Required for normal motor neuron development. Required for autophagosome formation; Belongs to the TMEM41 family."},{"id":"ENSMUSP00000020392","abundance":3.62,"rank":6541,"name":"9530003J23Rik","annotation":"RIKEN cDNA 9530003J23 gene; Belongs to the glycosyl hydrolase 22 family."},{"id":"ENSMUSP00000128331","abundance":3.62,"rank":6542,"name":"Nolc1","annotation":"Nucleolar and coiled-body phosphoprotein 1; Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (By similarity). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with TCOF1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (By similarity). Invol [...] "},{"id":"ENSMUSP00000069457","abundance":3.62,"rank":6543,"name":"Ghr","annotation":"Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway (By similarity)."},{"id":"ENSMUSP00000011055","abundance":3.62,"rank":6544,"name":"Apip","annotation":"Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily."},{"id":"ENSMUSP00000106964","abundance":3.62,"rank":6545,"name":"Pcp4l1","annotation":"Purkinje cell protein 4-like protein 1; Belongs to the PCP4 family."},{"id":"ENSMUSP00000023040","abundance":3.62,"rank":6546,"name":"Slc25a17","annotation":"Peroxisomal membrane protein PMP34; Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. Inhibited by pyridoxal 5'- phosphate and bathophenanthroline in vitro (By similarity)."},{"id":"ENSMUSP00000021800","abundance":3.61,"rank":6547,"name":"Mcur1","annotation":"Mitochondrial calcium uniporter regulator 1; Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex)."},{"id":"ENSMUSP00000055930","abundance":3.61,"rank":6548,"name":"Hs3st3a1","annotation":"Heparan sulfate glucosamine 3-O-sulfotransferase 3A1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)."},{"id":"ENSMUSP00000102192","abundance":3.61,"rank":6549,"name":"Cd300a","annotation":"CMRF35-like molecule 8; Inhibitory receptor which may contribute to the down- regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (By similarity)."},{"id":"ENSMUSP00000081573","abundance":3.61,"rank":6550,"name":"Cdc26","annotation":"Anaphase-promoting complex subunit CDC26; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity); Belongs to the CDC26  [...] "},{"id":"ENSMUSP00000007236","abundance":3.61,"rank":6551,"name":"Syngr3","annotation":"Synaptogyrin-3; May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal."},{"id":"ENSMUSP00000112423","abundance":3.61,"rank":6552,"name":"Shisa7","annotation":"Protein shisa-7; Transmembrane protein that regulates gamma-aminobutyric acid type A receptor (GABA(A)R) trafficking, channel deactivation kinetics and pharmacology, necessary for fast inhibitory transmission in the brain. Enhances the action of benzodiazepine, a primary GABA(A)Rs target drug, in the brain. May affect channel kinetics of AMPA-type glutamate receptors (AMPAR), the brain's main excitatory neurotransmitter, necessary for synaptic hippocampal plasticity, and memory recall (Probable). May regulate the induction and maintenance of long-term potentiation at Schaffer collatera [...] "},{"id":"ENSMUSP00000098723","abundance":3.61,"rank":6553,"name":"Limch1","annotation":"LIM and calponin homology domains-containing protein 1; Actin stress fibers-associated protein that activates non- muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. Belongs to the LIMCH1 family."},{"id":"ENSMUSP00000132142","abundance":3.6,"rank":6554,"name":"Galnt1","annotation":"Polypeptide N-acetylgalactosaminyltransferase 1 soluble form; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7; Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily."},{"id":"ENSMUSP00000035245","abundance":3.6,"rank":6555,"name":"Cinp","annotation":"Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling (By similarity)."},{"id":"ENSMUSP00000064608","abundance":3.6,"rank":6556,"name":"Gpr50","annotation":"Melatonin-related receptor; Does not bind melatonin; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000021204","abundance":3.6,"rank":6557,"name":"Nxn","annotation":"Nucleoredoxin; Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). Belongs to the nucleoredoxin family."},{"id":"ENSMUSP00000015725","abundance":3.59,"rank":6558,"name":"Bnip1","annotation":"Vesicle transport protein SEC20; As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Plays also a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy; Belongs to the SEC20 family."},{"id":"ENSMUSP00000022196","abundance":3.59,"rank":6559,"name":"Ap3b1","annotation":"AP-3 complex subunit beta-1; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into  [...] "},{"id":"ENSMUSP00000057592","abundance":3.59,"rank":6560,"name":"Trp53i13","annotation":"Tumor protein p53-inducible protein 13; May act as a tumor suppressor. Inhibits tumor cell growth, when overexpressed (By similarity)."},{"id":"ENSMUSP00000028948","abundance":3.59,"rank":6561,"name":"Gins1","annotation":"DNA replication complex GINS protein PSF1; Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA."},{"id":"ENSMUSP00000025230","abundance":3.59,"rank":6562,"name":"C2","annotation":"Complement C2a fragment; Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000066244","abundance":3.59,"rank":6563,"name":"Eya2","annotation":"Eyes absent homolog 2; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulat [...] "},{"id":"ENSMUSP00000064556","abundance":3.58,"rank":6564,"name":"Angel2","annotation":"Protein angel homolog 2."},{"id":"ENSMUSP00000101238","abundance":3.58,"rank":6565,"name":"Nadk","annotation":"NAD kinase; Belongs to the NAD kinase family."},{"id":"ENSMUSP00000029440","abundance":3.58,"rank":6566,"name":"Olfml3","annotation":"Olfactomedin-like protein 3; Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes (By similarity); Belongs to the OLFML3 family."},{"id":"ENSMUSP00000106046","abundance":3.58,"rank":6567,"name":"Usp8","annotation":"Ubiquitin carboxyl-terminal hydrolase 8; Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endoso [...] "},{"id":"ENSMUSP00000050488","abundance":3.58,"rank":6568,"name":"Lin28a","annotation":"Protein lin-28 homolog A; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets. 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRN [...] "},{"id":"ENSMUSP00000023134","abundance":3.57,"rank":6569,"name":"Glycam1","annotation":"Glycosylation-dependent cell adhesion molecule 1; Adhesion molecule that accomplishes cell binding by presenting carbohydrate(s) to the lectin domain of L-selectin; Belongs to the PP3/GlyCAM-1 family."},{"id":"ENSMUSP00000122552","abundance":3.57,"rank":6570,"name":"Dhrs3","annotation":"Short-chain dehydrogenase/reductase 3; Catalyzes the reduction of all-trans-retinal to all-trans- retinol in the presence of NADPH."},{"id":"ENSMUSP00000056959","abundance":3.57,"rank":6571,"name":"Zfp771","annotation":"Zinc finger protein 771; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000046601","abundance":3.57,"rank":6572,"name":"Pde1c","annotation":"Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C; Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual-specificity for cAMP and cGMP, which are key regulators of many important physiological processes. Exhibits high affinity for both cAMP and cGMP (By similarity). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable)."},{"id":"ENSMUSP00000009018","abundance":3.57,"rank":6573,"name":"Clec3a","annotation":"C-type lectin domain family 3 member A; Promotes cell adhesion to laminin and fibronectin."},{"id":"ENSMUSP00000049236","abundance":3.56,"rank":6574,"name":"Gipc3","annotation":"PDZ domain-containing protein GIPC3; Required for postnatal maturation of the hair bundle and long-term survival of hair cells and spiral ganglion."},{"id":"ENSMUSP00000063331","abundance":3.56,"rank":6575,"name":"Cgas","annotation":"Cyclic GMP-AMP synthase; Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second m [...] "},{"id":"ENSMUSP00000038298","abundance":3.56,"rank":6576,"name":"Zfp335","annotation":"Zinc finger protein 335; Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand- dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation; Belongs to the krueppel C2H2 [...] "},{"id":"ENSMUSP00000015576","abundance":3.56,"rank":6577,"name":"Mcpt2","annotation":"Mast cell protease 2."},{"id":"ENSMUSP00000033198","abundance":3.56,"rank":6578,"name":"Crym","annotation":"Ketimine reductase mu-crystallin; Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors (By similarity)."},{"id":"ENSMUSP00000072616","abundance":3.56,"rank":6579,"name":"Foxk1","annotation":"Forkhead box protein K1; Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), p [...] "},{"id":"ENSMUSP00000099888","abundance":3.56,"rank":6580,"name":"Ifit1","annotation":"Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-  [...] "},{"id":"ENSMUSP00000061470","abundance":3.55,"rank":6581,"name":"Tmtc3","annotation":"Protein O-mannosyl-transferase TMTC3; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response."},{"id":"ENSMUSP00000122435","abundance":3.55,"rank":6582,"name":"Polr3c","annotation":"DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during i [...] "},{"id":"ENSMUSP00000049614","abundance":3.55,"rank":6583,"name":"4930451I11Rik","annotation":"RIKEN cDNA 4930451I11 gene."},{"id":"ENSMUSP00000143094","abundance":3.55,"rank":6584,"name":"Fgf2","annotation":"Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family."},{"id":"ENSMUSP00000153357","abundance":3.55,"rank":6585,"name":"Cdadc1","annotation":"Cytidine and dCMP deaminase domain-containing protein 1; May play an important role in testicular development and spermatogenesis."},{"id":"ENSMUSP00000038204","abundance":3.54,"rank":6586,"name":"Rag2","annotation":"V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] "},{"id":"ENSMUSP00000020617","abundance":3.54,"rank":6587,"name":"Flt4","annotation":"Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by  [...] "},{"id":"ENSMUSP00000099419","abundance":3.54,"rank":6588,"name":"Dsn1","annotation":"Kinetochore-associated protein DSN1 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis."},{"id":"ENSMUSP00000022551","abundance":3.54,"rank":6589,"name":"Rcbtb1","annotation":"RCC1 and BTB domain-containing protein 1; May be involved in cell cycle regulation by chromatin remodeling."},{"id":"ENSMUSP00000103386","abundance":3.53,"rank":6590,"name":"Coro2a","annotation":"Coronin-2A."},{"id":"ENSMUSP00000032566","abundance":3.53,"rank":6591,"name":"Qpctl","annotation":"Glutaminyl-peptide cyclotransferase-like protein; Responsible for the biosynthesis of pyroglutamyl peptides. Belongs to the glutaminyl-peptide cyclotransferase family."},{"id":"ENSMUSP00000040033","abundance":3.53,"rank":6592,"name":"Npffr2","annotation":"Neuropeptide FF receptor 2; Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity)."},{"id":"ENSMUSP00000132288","abundance":3.53,"rank":6593,"name":"Dnajc28","annotation":"DnaJ homolog subfamily C member 28; May have a role in protein folding or as a chaperone."},{"id":"ENSMUSP00000058221","abundance":3.53,"rank":6594,"name":"Lemd2","annotation":"LEM domain-containing protein 2; Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope (By similarity)."},{"id":"ENSMUSP00000041428","abundance":3.53,"rank":6595,"name":"Prpf18","annotation":"Pre-mRNA-splicing factor 18; Participates in the second step of pre-mRNA splicing."},{"id":"ENSMUSP00000026175","abundance":3.53,"rank":6596,"name":"Fn3k","annotation":"Fructosamine-3-kinase; Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (By similarity). Involved in intracellular deglycation in erythrocytes and pancreatic islets. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines (By similarity)."},{"id":"ENSMUSP00000023259","abundance":3.53,"rank":6597,"name":"Lynx1","annotation":"Ly-6/neurotoxin-like protein 1; Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane.Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and ex [...] "},{"id":"ENSMUSP00000146921","abundance":3.53,"rank":6598,"name":"Zfp524","annotation":"Zinc finger protein 524; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000003645","abundance":3.53,"rank":6599,"name":"Ercc1","annotation":"DNA excision repair protein ERCC-1; Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4 (By similarity)."},{"id":"ENSMUSP00000048337","abundance":3.53,"rank":6600,"name":"Wdr43","annotation":"WD repeat-containing protein 43; Ribosome biogenesis factor that coordinates hyperactive transcription and ribogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I (By similarity). Essential for stem cell pluripotency and embryonic development. In the nucleoplasm, recruited by promoter-associated/nascent transcripts and transcription to active promoters where it facilitates releases of elongation factor P-TEFb and paused RNA polymerase II to allow transcription elongation and maintain high-level exp [...] "},{"id":"ENSMUSP00000102482","abundance":3.52,"rank":6601,"name":"Insl5","annotation":"Insulin-like peptide INSL5 A chain; May have a role in gut contractility or in thymic development and regulation. Activates RXFP4 with high potency and appears to be the endogenous ligand for this receptor (By similarity); Belongs to the insulin family."},{"id":"ENSMUSP00000015358","abundance":3.52,"rank":6602,"name":"Mtmr1","annotation":"Myotubularin-related protein 1; Lipid phosphatase that has high specificity for phosphatidylinositol 3-phosphate and has no activity with phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)- bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Activity with phosphatidylinositol (3,5)- bisphosphate is controversial; it has been shown for the human ortholog (By similarity). In contrast, find no activity with this substrate."},{"id":"ENSMUSP00000121125","abundance":3.52,"rank":6603,"name":"Tle2","annotation":"Transducin-like enhancer protein 2; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full- length TLE family members may be modulated by association with dominant-negative AES (By similarity)."},{"id":"ENSMUSP00000152987","abundance":3.52,"rank":6604,"name":"Pxk","annotation":"PX domain-containing protein kinase-like protein; Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity."},{"id":"ENSMUSP00000081953","abundance":3.52,"rank":6605,"name":"Pacs2","annotation":"Phosphofurin acidic cluster sorting protein 2; Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct s [...] "},{"id":"ENSMUSP00000052654","abundance":3.52,"rank":6606,"name":"Pop1","annotation":"Processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)."},{"id":"ENSMUSP00000021259","abundance":3.52,"rank":6607,"name":"Gucy2e","annotation":"Retinal guanylyl cyclase 1; Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane."},{"id":"ENSMUSP00000059666","abundance":3.52,"rank":6608,"name":"Pde12","annotation":"2',5'-phosphodiesterase 12; Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured  [...] "},{"id":"ENSMUSP00000034015","abundance":3.51,"rank":6609,"name":"Msmo1","annotation":"Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family."},{"id":"ENSMUSP00000099627","abundance":3.51,"rank":6610,"name":"Med18","annotation":"Mediator of RNA polymerase II transcription subunit 18; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000044814","abundance":3.51,"rank":6611,"name":"Mucl2","annotation":"Mucin-like protein 2."},{"id":"ENSMUSP00000118105","abundance":3.51,"rank":6612,"name":"Taf10","annotation":"Transcription initiation factor TFIID subunit 10; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May regulate cyclin E expression; Belongs to the TAF10 family."},{"id":"ENSMUSP00000083101","abundance":3.51,"rank":6613,"name":"Fxyd6","annotation":"FXYD domain-containing ion transport regulator 6; Belongs to the FXYD family."},{"id":"ENSMUSP00000137607","abundance":3.51,"rank":6614,"name":"Slco1a5","annotation":"Solute carrier organic anion transporter family member 1A5; Mediates the Na(+)-independent transport of organic anions such as taurocholate and thyroid hormones; Belongs to the organo anion transporter (TC 2.A.60) family."},{"id":"ENSMUSP00000017864","abundance":3.51,"rank":6615,"name":"Trp53tg5","annotation":"Transformation-related protein 53 target 5."},{"id":"ENSMUSP00000114974","abundance":3.51,"rank":6616,"name":"Spopl","annotation":"Speckle-type POZ protein-like; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin- protein ligase complexes [...] "},{"id":"ENSMUSP00000127816","abundance":3.51,"rank":6617,"name":"Baiap2l2","annotation":"Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide."},{"id":"ENSMUSP00000034096","abundance":3.5,"rank":6618,"name":"Setd6","annotation":"N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (By similarity). Required for the maintenance of embryonic stem cell self-renewal."},{"id":"ENSMUSP00000049584","abundance":3.5,"rank":6619,"name":"Itpr2","annotation":"Inositol 1,4,5-trisphosphate receptor type 2; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA."},{"id":"ENSMUSP00000029297","abundance":3.5,"rank":6620,"name":"Slc7a11","annotation":"Cystine/glutamate transporter; Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate."},{"id":"ENSMUSP00000050309","abundance":3.5,"rank":6621,"name":"Cnpy3","annotation":"Protein canopy homolog 3; Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses."},{"id":"ENSMUSP00000141951","abundance":3.5,"rank":6622,"name":"Mynn","annotation":"Myoneurin; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000042374","abundance":3.5,"rank":6623,"name":"Hspb2","annotation":"Heat shock protein beta-2; May regulate the kinase DMPK; Belongs to the small heat shock protein (HSP20) family."},{"id":"ENSMUSP00000140244","abundance":3.5,"rank":6624,"name":"Taf9","annotation":"TATA-box binding protein associated factor 9."},{"id":"ENSMUSP00000081772","abundance":3.5,"rank":6625,"name":"Ak6","annotation":"Transcription initiation factor TFIID subunit 9; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity)."},{"id":"ENSMUSP00000063272","abundance":3.49,"rank":6626,"name":"Ascc2","annotation":"Activating signal cointegrator 1 complex subunit 2; Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation."},{"id":"ENSMUSP00000058954","abundance":3.49,"rank":6627,"name":"Trmt10c","annotation":"tRNA methyltransferase 10 homolog C; Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 a [...] "},{"id":"ENSMUSP00000034992","abundance":3.49,"rank":6628,"name":"Nt5e","annotation":"5'-nucleotidase; Hydrolyzes extracellular nucleotides into membrane permeable nucleosides."},{"id":"ENSMUSP00000049776","abundance":3.49,"rank":6629,"name":"Ankfn1","annotation":"Ankyrin-repeat and fibronectin type III domain-containing 1."},{"id":"ENSMUSP00000124085","abundance":3.49,"rank":6630,"name":"Aoc1","annotation":"Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis."},{"id":"ENSMUSP00000029453","abundance":3.49,"rank":6631,"name":"Vangl1","annotation":"Vang-like protein 1."},{"id":"ENSMUSP00000100066","abundance":3.49,"rank":6632,"name":"Ssx9","annotation":"Synovial sarcoma, X 9."},{"id":"ENSMUSP00000088176","abundance":3.49,"rank":6633,"name":"Ddx20","annotation":"Probable ATP-dependent RNA helicase DDX20; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm compl [...] "},{"id":"ENSMUSP00000044858","abundance":3.48,"rank":6634,"name":"Crtac1","annotation":"Cartilage acidic protein 1."},{"id":"ENSMUSP00000035823","abundance":3.48,"rank":6635,"name":"Sec24d","annotation":"Sec24-related gene family, member D (S. cerevisiae)."},{"id":"ENSMUSP00000061546","abundance":3.48,"rank":6636,"name":"Nkrf","annotation":"NF-kappa-B-repressing factor; Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK- kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription (By similarity)."},{"id":"ENSMUSP00000124354","abundance":3.48,"rank":6637,"name":"Panx2","annotation":"Pannexin-2; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family."},{"id":"ENSMUSP00000112137","abundance":3.48,"rank":6638,"name":"Ahr","annotation":"Aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing [...] "},{"id":"ENSMUSP00000035218","abundance":3.48,"rank":6639,"name":"Nckipsd","annotation":"NCK-interacting protein with SH3 domain; Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1) (By similarity). Induces microspike formation, in vivo. In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42. May play an important role in the maintenance of sarcomere and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion."},{"id":"ENSMUSP00000095781","abundance":3.48,"rank":6640,"name":"Trim5","annotation":"Tripartite motif-containing 5."},{"id":"ENSMUSP00000039688","abundance":3.48,"rank":6641,"name":"Kri1","annotation":"Protein KRI1 homolog; Belongs to the KRI1 family."},{"id":"ENSMUSP00000035964","abundance":3.48,"rank":6642,"name":"Clcn7","annotation":"H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily."},{"id":"ENSMUSP00000030311","abundance":3.48,"rank":6643,"name":"Ift74","annotation":"Intraflagellar transport protein 74 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis (By similarity)."},{"id":"ENSMUSP00000062464","abundance":3.48,"rank":6644,"name":"Ppp1r13b","annotation":"Apoptosis-stimulating of p53 protein 1; Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (By similarity). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo (By similarity)."},{"id":"ENSMUSP00000028123","abundance":3.48,"rank":6645,"name":"Gad2","annotation":"Glutamate decarboxylase 2; Catalyzes the production of GABA."},{"id":"ENSMUSP00000032129","abundance":3.48,"rank":6646,"name":"Gkn1","annotation":"Gastrokine-1; Has mitogenic activity and may be involved in maintaining the integrity of the gastric mucosal epithelium."},{"id":"ENSMUSP00000025647","abundance":3.47,"rank":6647,"name":"Pga5","annotation":"Pepsin A-5; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent (By similarity). May play a role as a specialized neonatal digestive enzyme (Probable). Belongs to the peptidase A1 family."},{"id":"ENSMUSP00000025581","abundance":3.47,"rank":6648,"name":"Ms4a4d","annotation":"Membrane-spanning 4-domains subfamily A member 4D; May be involved in signal transduction as a component of a multimeric receptor complex."},{"id":"ENSMUSP00000101537","abundance":3.47,"rank":6649,"name":"Slc22a18","annotation":"Solute carrier family 22 member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (By similarity). Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family."},{"id":"ENSMUSP00000105111","abundance":3.47,"rank":6650,"name":"Ralgapb","annotation":"Ral GTPase-activating protein subunit beta; Non-catalytic subunit of the heterodimeric RalGAP1 and RalGAP2 complexes which act as GTPase activators for the Ras-like small GTPases RALA and RALB."},{"id":"ENSMUSP00000072248","abundance":3.47,"rank":6651,"name":"Olfr854","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000061891","abundance":3.47,"rank":6652,"name":"Ift43","annotation":"Intraflagellar transport protein 43 homolog; As a component of IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in ciliogenesis. Involved in retrograde ciliary transport along microtubules from the ciliary tip to the base."},{"id":"ENSMUSP00000060462","abundance":3.47,"rank":6653,"name":"Hacd2","annotation":"Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursor [...] "},{"id":"ENSMUSP00000075916","abundance":3.46,"rank":6654,"name":"Crtc1","annotation":"CREB-regulated transcription coactivator 1; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated. Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocam [...] "},{"id":"ENSMUSP00000045283","abundance":3.46,"rank":6655,"name":"Dnph1","annotation":"2'-deoxynucleoside 5'-phosphate N-hydrolase 1; Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases."},{"id":"ENSMUSP00000099018","abundance":3.46,"rank":6656,"name":"Peli1","annotation":"E3 ubiquitin-protein ligase pellino homolog 1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3.  [...] "},{"id":"ENSMUSP00000103586","abundance":3.46,"rank":6657,"name":"Unc13b","annotation":"Protein unc-13 homolog B; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and  [...] "},{"id":"ENSMUSP00000036203","abundance":3.46,"rank":6658,"name":"Adra2a","annotation":"Alpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins."},{"id":"ENSMUSP00000056765","abundance":3.46,"rank":6659,"name":"Ubtd2","annotation":"Ubiquitin domain-containing protein 2."},{"id":"ENSMUSP00000070238","abundance":3.46,"rank":6660,"name":"Retnlg","annotation":"Resistin-like gamma; Probable hormone (Probable). Promotes chemotaxis in myeloid cells ; Belongs to the resistin/FIZZ family."},{"id":"ENSMUSP00000109123","abundance":3.46,"rank":6661,"name":"Taf9b","annotation":"Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription (By similarity)."},{"id":"ENSMUSP00000002840","abundance":3.46,"rank":6662,"name":"Pex6","annotation":"Peroxisome assembly factor 2; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Probably required for protein import into peroxisomes. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity)."},{"id":"ENSMUSP00000095043","abundance":3.46,"rank":6663,"name":"Serac1","annotation":"Protein SERAC1; Plays an important role in the phosphatidylglycerol remodeling that is essential for both mitochondrial function and intracellular cholesterol trafficking. May catalyze the remodeling of phosphatidylglycerol and be involved in the transacylation-acylation reaction to produce phosphatidylglycerol-36:1. May be involved in bis(monoacylglycerol)phosphate biosynthetic pathway (By similarity). Belongs to the SERAC1 family."},{"id":"ENSMUSP00000140393","abundance":3.46,"rank":6664,"name":"Begain","annotation":"Brain-enriched guanylate kinase-associated protein; May sustain the structure of the postsynaptic density (PSD)."},{"id":"ENSMUSP00000057984","abundance":3.46,"rank":6665,"name":"Riox1","annotation":"Ribosomal oxygenase 1; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation (By similarity). Specifically demethylates 'Lys- [...] "},{"id":"ENSMUSP00000099397","abundance":3.45,"rank":6666,"name":"Wnk4","annotation":"Serine/threonine-protein kinase WNK4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-in [...] "},{"id":"ENSMUSP00000068103","abundance":3.45,"rank":6667,"name":"Utp18","annotation":"U3 small nucleolar RNA-associated protein 18 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the WD repeat UTP18 family."},{"id":"ENSMUSP00000019469","abundance":3.45,"rank":6668,"name":"G6pc","annotation":"Glucose-6-phosphatase; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels."},{"id":"ENSMUSP00000078070","abundance":3.45,"rank":6669,"name":"Sox11","annotation":"Transcription factor SOX-11; Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development."},{"id":"ENSMUSP00000031304","abundance":3.45,"rank":6670,"name":"Tesc","annotation":"Calcineurin B homologous protein 3; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the pho [...] "},{"id":"ENSMUSP00000047888","abundance":3.44,"rank":6671,"name":"Cacng5","annotation":"Voltage-dependent calcium channel gamma-5 subunit; Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily."},{"id":"ENSMUSP00000086565","abundance":3.44,"rank":6672,"name":"Edem1","annotation":"ER degradation-enhancing alpha-mannosidase-like protein 1; Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan- independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2."},{"id":"ENSMUSP00000112603","abundance":3.44,"rank":6673,"name":"Emcn","annotation":"Endomucin; Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix."},{"id":"ENSMUSP00000035289","abundance":3.44,"rank":6674,"name":"Polr3g","annotation":"DNA-directed RNA polymerase III subunit RPC7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating cata [...] "},{"id":"ENSMUSP00000023328","abundance":3.43,"rank":6675,"name":"Retnlb","annotation":"Resistin-like beta; Probable hormone."},{"id":"ENSMUSP00000139559","abundance":3.43,"rank":6676,"name":"Ly6c1","annotation":"Lymphocyte antigen 6C1."},{"id":"ENSMUSP00000084905","abundance":3.43,"rank":6677,"name":"Adamts10","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 10; Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues (By similarity)."},{"id":"ENSMUSP00000057939","abundance":3.43,"rank":6678,"name":"Gskip","annotation":"GSK3B-interacting protein; A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron [...] "},{"id":"ENSMUSP00000106163","abundance":3.43,"rank":6679,"name":"Arid4b","annotation":"AT-rich interactive domain-containing protein 4B; Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enha [...] "},{"id":"ENSMUSP00000099805","abundance":3.43,"rank":6680,"name":"Orc1","annotation":"Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity)."},{"id":"ENSMUSP00000019512","abundance":3.43,"rank":6681,"name":"Sec14l4","annotation":"SEC14-like protein 4; Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids."},{"id":"ENSMUSP00000034003","abundance":3.43,"rank":6682,"name":"Fgl1","annotation":"Fibrinogen-like protein 1; Immune suppressive molecule that inhibits antigen-specific T- cell activation by acting as a major ligand of LAG3. Responsible for LAG3 T-cell inhibitory function. Binds LAG3 independently from MHC class II (MHC-II). Secreted by, and promotes growth of, hepatocytes (By similarity)."},{"id":"ENSMUSP00000047588","abundance":3.43,"rank":6683,"name":"Coil","annotation":"Coilin; Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs."},{"id":"ENSMUSP00000059503","abundance":3.43,"rank":6684,"name":"Mtus1","annotation":"Microtubule-associated tumor suppressor 1 homolog; Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation."},{"id":"ENSMUSP00000060749","abundance":3.43,"rank":6685,"name":"Llgl1","annotation":"Lethal(2) giant larvae protein homolog 1; Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane."},{"id":"ENSMUSP00000033689","abundance":3.42,"rank":6686,"name":"Cdx4","annotation":"Homeobox protein CDX-4."},{"id":"ENSMUSP00000047029","abundance":3.42,"rank":6687,"name":"Tspan15","annotation":"Tetraspanin-15; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Promotes ADAM10-mediated cleavage of (CDH2). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity); Belongs to the tetraspanin (TM4SF) family."},{"id":"ENSMUSP00000128256","abundance":3.42,"rank":6688,"name":"Slc39a3","annotation":"Zinc transporter ZIP3; Acts as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family."},{"id":"ENSMUSP00000128287","abundance":3.42,"rank":6689,"name":"Rtl9","annotation":"Retrotransposon Gag-like protein 9."},{"id":"ENSMUSP00000029564","abundance":3.42,"rank":6690,"name":"Pmvk","annotation":"Phosphomevalonate kinase."},{"id":"ENSMUSP00000045755","abundance":3.42,"rank":6691,"name":"Cpne2","annotation":"Copine-2; Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium- dependent cell membrane binding properties."},{"id":"ENSMUSP00000025110","abundance":3.42,"rank":6692,"name":"Syt4","annotation":"Synaptotagmin-4; Synaptotagmin family member which does not bind Ca(2+). Plays a role in dendrite formation by melanocytes (By similarity)."},{"id":"ENSMUSP00000058077","abundance":3.42,"rank":6693,"name":"Ccdc126","annotation":"Coiled-coil domain-containing protein 126."},{"id":"ENSMUSP00000041307","abundance":3.42,"rank":6694,"name":"Sgtb","annotation":"Small glutamine-rich tetratricopeptide repeat-containing protein beta; Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity; Belongs to the SGT family."},{"id":"ENSMUSP00000070241","abundance":3.42,"rank":6695,"name":"Micu3","annotation":"Calcium uptake protein 3, mitochondrial; May play a role in mitochondrial calcium uptake. Belongs to the MICU1 family. MICU3 subfamily."},{"id":"ENSMUSP00000001115","abundance":3.41,"rank":6696,"name":"Grk6","annotation":"G protein-coupled receptor kinase 6; Specifically phosphorylates the activated forms of G protein- coupled receptors. Such receptor phosphorylation initiates beta- arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity)."},{"id":"ENSMUSP00000027826","abundance":3.41,"rank":6697,"name":"Dusp23","annotation":"Dual specificity protein phosphatase 23; Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000112685","abundance":3.41,"rank":6698,"name":"Slc29a3","annotation":"Equilibrative nucleoside transporter 3; Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine (By similarity); Belongs to the SLC29A/ENT transporter (TC 2.A.57) family."},{"id":"ENSMUSP00000151474","abundance":3.41,"rank":6699,"name":"Olfr676","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000112432","abundance":3.41,"rank":6700,"name":"Syt3","annotation":"Synaptotagmin-3; Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis. Plays a role in dendrite formation by melanocytes."},{"id":"ENSMUSP00000111359","abundance":3.41,"rank":6701,"name":"Magix","annotation":"PDZ domain-containing protein MAGIX."},{"id":"ENSMUSP00000077345","abundance":3.41,"rank":6702,"name":"Serhl","annotation":"Serine hydrolase-like protein; Probable serine hydrolase. May be related to cell muscle hypertrophy."},{"id":"ENSMUSP00000026288","abundance":3.41,"rank":6703,"name":"Ribc1","annotation":"RIB43A-like with coiled-coils protein 1; Belongs to the RIB43A family."},{"id":"ENSMUSP00000006353","abundance":3.4,"rank":6704,"name":"Cdkal1","annotation":"Threonylcarbamoyladenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6- threonylcarbamoyladenosine (t(6)A), leading to the formation of 2- methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. Belongs to the methylthiotransferase family. CDKAL1 subfamily."},{"id":"ENSMUSP00000086207","abundance":3.4,"rank":6705,"name":"Mapk12","annotation":"Mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...] "},{"id":"ENSMUSP00000130802","abundance":3.4,"rank":6706,"name":"Oard1","annotation":"ADP-ribose glycohydrolase OARD1; ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP- ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a sig [...] "},{"id":"ENSMUSP00000154250","abundance":3.4,"rank":6707,"name":"Dpep2-2","annotation":"Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family."},{"id":"ENSMUSP00000110435","abundance":3.4,"rank":6708,"name":"Stxbp5l","annotation":"Syntaxin-binding protein 5-like; Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth (By similarity). Belongs to the WD repeat L(2)GL family."},{"id":"ENSMUSP00000068197","abundance":3.4,"rank":6709,"name":"Zmym3","annotation":"Zinc finger MYM-type protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization."},{"id":"ENSMUSP00000075240","abundance":3.4,"rank":6710,"name":"Adgre5","annotation":"CD97 antigen subunit alpha; Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration."},{"id":"ENSMUSP00000013227","abundance":3.4,"rank":6711,"name":"2200002J24Rik","annotation":"RIKEN cDNA 2200002J24 gene."},{"id":"ENSMUSP00000151239","abundance":3.4,"rank":6712,"name":"Gstt2","annotation":"Glutathione S-transferase theta-2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles."},{"id":"ENSMUSP00000047186","abundance":3.4,"rank":6713,"name":"Dap","annotation":"Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity)."},{"id":"ENSMUSP00000030800","abundance":3.4,"rank":6714,"name":"Fastk","annotation":"Fas-activated serine/threonine kinase; Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro- apoptotic form of the receptor (By similarity). Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels; Belongs to the FAST protein kinase family."},{"id":"ENSMUSP00000131842","abundance":3.39,"rank":6715,"name":"Gemin5","annotation":"Gem-associated protein 5; Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive  [...] "},{"id":"ENSMUSP00000026170","abundance":3.39,"rank":6716,"name":"Ubtd1","annotation":"Ubiquitin domain-containing protein 1; May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2."},{"id":"ENSMUSP00000106991","abundance":3.39,"rank":6717,"name":"LOC100041057","annotation":"RIKEN cDNA C130026I21 gene."},{"id":"ENSMUSP00000080694","abundance":3.39,"rank":6718,"name":"Rps6ka6","annotation":"Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis."},{"id":"ENSMUSP00000134053","abundance":3.39,"rank":6719,"name":"Zic4","annotation":"Zinc finger protein ZIC 4; Binds to DNA; Belongs to the GLI C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000101854","abundance":3.38,"rank":6720,"name":"Adh6a","annotation":"Alcohol dehydrogenase 6A (class V)."},{"id":"ENSMUSP00000084405","abundance":3.38,"rank":6721,"name":"Lnx1","annotation":"E3 ubiquitin-protein ligase LNX; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NUMB. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of isoform p66 and isoform p72 of NUMB, but not that of isoform p71 or isoform p65."},{"id":"ENSMUSP00000095752","abundance":3.38,"rank":6722,"name":"Rrp8","annotation":"Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] "},{"id":"ENSMUSP00000022257","abundance":3.38,"rank":6723,"name":"Atxn7","annotation":"Ataxin-7; Involved in neurodegeneration. Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation (By similarity). Necessary for microtubule cytoskeleton stabilization (By similarity)."},{"id":"ENSMUSP00000086017","abundance":3.38,"rank":6724,"name":"Wnk1","annotation":"Serine/threonine-protein kinase WNK1; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thia [...] "},{"id":"ENSMUSP00000085651","abundance":3.38,"rank":6725,"name":"Gbx1","annotation":"Homeobox protein GBX-1."},{"id":"ENSMUSP00000034363","abundance":3.38,"rank":6726,"name":"Hsd11b2","annotation":"Corticosteroid 11-beta-dehydrogenase isozyme 2; Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000125607","abundance":3.38,"rank":6727,"name":"Gm28038","annotation":"Predicted gene, 28038."},{"id":"ENSMUSP00000027396","abundance":3.38,"rank":6728,"name":"Abcb6","annotation":"ATP-binding cassette sub-family B member 6, mitochondrial; Binds heme and porphyrins and functions in their ATP- dependent uptake into the mitochondria. Plays a crucial role in heme synthesis."},{"id":"ENSMUSP00000034497","abundance":3.38,"rank":6729,"name":"Mmp3","annotation":"Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase."},{"id":"ENSMUSP00000103845","abundance":3.38,"rank":6730,"name":"Ttc14","annotation":"Tetratricopeptide repeat protein 14."},{"id":"ENSMUSP00000036149","abundance":3.38,"rank":6731,"name":"Afg1l","annotation":"AFG1-like ATPase; Putative mitochondrial ATPase. Plays a role in mitochondrial morphology and mitochondrial protein metabolism. Promotes degradation of excess nuclear-encoded complex IV subunits (COX4I1, COX5A and COX6A1) and normal activity of complexes III and IV of the respiratory chain. Mediates mitochondrial translocation of TP53 and its transcription-independent apoptosis in response to genotoxic stress."},{"id":"ENSMUSP00000002883","abundance":3.38,"rank":6732,"name":"Sfrp4","annotation":"Secreted frizzled-related sequence protein 4; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity)."},{"id":"ENSMUSP00000145487","abundance":3.38,"rank":6733,"name":"Sinhcaf","annotation":"SIN3-HDAC complex-associated factor; Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (By similarity). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage [...] "},{"id":"ENSMUSP00000072883","abundance":3.37,"rank":6734,"name":"Ndrg4","annotation":"Protein NDRG4; Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner."},{"id":"ENSMUSP00000043981","abundance":3.37,"rank":6735,"name":"Nop53","annotation":"Ribosome biogenesis protein NOP53; Nucleolar protein which is involved in the integration of the 5S RNP into the ribosomal large subunit during ribosome biogenesis. In ribosome biogenesis, may also play a role in rRNA transcription (By similarity). Also functions as a nucleolar sensor that regulates the activation of p53/TP53 in response to ribosome biogenesis perturbation, DNA damage and other stress conditions. DNA damage or perturbation of ribosome biogenesis disrupt the interaction between NOP53 and RPL11 allowing RPL11 transport to the nucleoplasm where it can inhibit MDM2 and all [...] "},{"id":"ENSMUSP00000072643","abundance":3.37,"rank":6736,"name":"Ubap1","annotation":"Ubiquitin-associated protein 1; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) (By similarity). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2."},{"id":"ENSMUSP00000048415","abundance":3.37,"rank":6737,"name":"Josd2","annotation":"Josephin-2; Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme (By similarity)."},{"id":"ENSMUSP00000053862","abundance":3.37,"rank":6738,"name":"Tmem186","annotation":"Transmembrane protein 186."},{"id":"ENSMUSP00000110639","abundance":3.37,"rank":6739,"name":"Fam234a","annotation":"Protein FAM234A."},{"id":"ENSMUSP00000140208","abundance":3.37,"rank":6740,"name":"Mdfic","annotation":"MyoD family inhibitor domain-containing protein; Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta- catenin. Affects axin-regulation of the WNT and JNK signaling pathways."},{"id":"ENSMUSP00000085796","abundance":3.37,"rank":6741,"name":"Xlr5c","annotation":"X-linked lymphocyte-regulated protein 5C."},{"id":"ENSMUSP00000020529","abundance":3.36,"rank":6742,"name":"Ahsa2","annotation":"Activator of 90 kDa heat shock protein ATPase homolog 2; Co-chaperone that stimulates HSP90 ATPase activity. Belongs to the AHA1 family."},{"id":"ENSMUSP00000033264","abundance":3.36,"rank":6743,"name":"Trim21","annotation":"E3 ubiquitin-protein ligase TRIM21; E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degrad [...] "},{"id":"ENSMUSP00000084868","abundance":3.36,"rank":6744,"name":"Boll","annotation":"Protein boule-like; Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation (By similarity); Belongs to the RRM DAZ family."},{"id":"ENSMUSP00000036523","abundance":3.36,"rank":6745,"name":"Esf1","annotation":"ESF1 homolog; May constitute a novel regulatory system for basal transcription. Negatively regulates ABT1 (By similarity)."},{"id":"ENSMUSP00000036845","abundance":3.36,"rank":6746,"name":"Dgat2l6","annotation":"Diacylglycerol O-acyltransferase 2-like protein 6; Diglyceride acyltransferase that uses fatty acyl-CoA as substrate. Particularly active with oleate as a substrate. Has no wax synthase activity to produce wax esters."},{"id":"ENSMUSP00000128209","abundance":3.36,"rank":6747,"name":"Acss3","annotation":"Acyl-CoA synthetase short-chain family member 3, mitochondrial; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (By similarity). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family."},{"id":"ENSMUSP00000114583","abundance":3.36,"rank":6748,"name":"Ugt2a1","annotation":"UDP-glucuronosyltransferase 2A1; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Active on odorants and seems to be involved in olfaction; it could help clear lipophilic odorant molecules from the sensory epithelium."},{"id":"ENSMUSP00000043691","abundance":3.35,"rank":6749,"name":"Atad2","annotation":"ATPase family AAA domain-containing protein 2; May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation (By similarity); Belongs to the AAA ATPase family."},{"id":"ENSMUSP00000099654","abundance":3.35,"rank":6750,"name":"1110051M20Rik","annotation":"UPF0705 protein C11orf49 homolog."},{"id":"ENSMUSP00000112679","abundance":3.35,"rank":6751,"name":"Sult1b1","annotation":"Sulfotransferase family cytosolic 1B member 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates L-DOPA and D-DOPA, tyrosine isomers such as DL-m-tyrosine, dopamine and thyroid hormones."},{"id":"ENSMUSP00000048489","abundance":3.35,"rank":6752,"name":"Coro7","annotation":"Coronin-7; F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology (By similarity)."},{"id":"ENSMUSP00000108934","abundance":3.35,"rank":6753,"name":"Armc9","annotation":"LisH domain-containing protein ARMC9; Acts as a positive regulator of hedgehog (Hh) signaling. Involved in ciliogenesis (By similarity). May participate in the trafficking and/or retention of GLI2 and GLI3 proteins at the ciliary tip."},{"id":"ENSMUSP00000033025","abundance":3.35,"rank":6754,"name":"Lcmt1","annotation":"Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family."},{"id":"ENSMUSP00000113407","abundance":3.35,"rank":6755,"name":"Nmb","annotation":"Neuromedin-B-32; Stimulates smooth muscle contraction in a manner similar to that of bombesin; Belongs to the bombesin/neuromedin-B/ranatensin family."},{"id":"ENSMUSP00000020920","abundance":3.35,"rank":6756,"name":"Rgs9","annotation":"Regulator of G-protein signaling 9; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction."},{"id":"ENSMUSP00000055475","abundance":3.35,"rank":6757,"name":"Unc119b","annotation":"Protein unc-119 homolog B; Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells (By similarity)."},{"id":"ENSMUSP00000102116","abundance":3.35,"rank":6758,"name":"Mif4gd","annotation":"MIF4G domain-containing protein; Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation (By similarity). Belongs to the MIF4GD family."},{"id":"ENSMUSP00000027970","abundance":3.35,"rank":6759,"name":"Dusp12","annotation":"Dual specificity protein phosphatase 12; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates."},{"id":"ENSMUSP00000035326","abundance":3.35,"rank":6760,"name":"Hif1an","annotation":"Hypoxia-inducible factor 1-alpha inhibitor; Hydroxylates HIF-1 alpha at 'Asn-799' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylat [...] "},{"id":"ENSMUSP00000059092","abundance":3.35,"rank":6761,"name":"C130073F10Rik","annotation":"RIKEN cDNA C130073F10 gene."},{"id":"ENSMUSP00000062449","abundance":3.35,"rank":6762,"name":"Rbm33","annotation":"RNA-binding protein 33."},{"id":"ENSMUSP00000102268","abundance":3.35,"rank":6763,"name":"Zfyve9","annotation":"Zinc finger FYVE domain-containing protein."},{"id":"ENSMUSP00000058021","abundance":3.35,"rank":6764,"name":"Timeless","annotation":"Protein timeless homolog; Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication, DNA repair and in the regulation of the circadian clock. Required to stabilize replication forks during DNA replication by forming a complex with TIPIN: this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. TIMELESS promotes [...] "},{"id":"ENSMUSP00000033934","abundance":3.34,"rank":6765,"name":"Mrps31","annotation":"28S ribosomal protein S31, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS31 family."},{"id":"ENSMUSP00000091505","abundance":3.34,"rank":6766,"name":"Npnt","annotation":"Nephronectin; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins."},{"id":"ENSMUSP00000126656","abundance":3.34,"rank":6767,"name":"Kcnb2","annotation":"Potassium voltage-gated channel subfamily B member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric an [...] "},{"id":"ENSMUSP00000033483","abundance":3.34,"rank":6768,"name":"Ccdc22","annotation":"Coiled-coil domain-containing protein 22; Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via association with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Component of the CCC complex, which is inv [...] "},{"id":"ENSMUSP00000043837","abundance":3.34,"rank":6769,"name":"Itln1","annotation":"Intelectin-1a; Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner. Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol- modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3- deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram- positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind mammalian glycans. Probably plays a role in the defense system agains [...] "},{"id":"ENSMUSP00000136972","abundance":3.34,"rank":6770,"name":"Lig1","annotation":"DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair."},{"id":"ENSMUSP00000050057","abundance":3.34,"rank":6771,"name":"BC053393","annotation":"cDNA sequence BC053393."},{"id":"ENSMUSP00000075933","abundance":3.34,"rank":6772,"name":"Zfp280c","annotation":"Zinc finger protein 280C; May function as a transcription factor."},{"id":"ENSMUSP00000124278","abundance":3.34,"rank":6773,"name":"Hmgn3","annotation":"High mobility group nucleosome-binding domain-containing protein 3; Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glyci [...] "},{"id":"ENSMUSP00000114016","abundance":3.34,"rank":6774,"name":"Pgap2","annotation":"Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family."},{"id":"ENSMUSP00000057858","abundance":3.34,"rank":6775,"name":"Phospho1","annotation":"Phosphoethanolamine/phosphocholine phosphatase; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization."},{"id":"ENSMUSP00000018522","abundance":3.33,"rank":6776,"name":"Cuedc1","annotation":"CUE domain-containing protein 1."},{"id":"ENSMUSP00000052458","abundance":3.33,"rank":6777,"name":"Bend7","annotation":"BEN domain-containing protein 7."},{"id":"ENSMUSP00000045376","abundance":3.33,"rank":6778,"name":"2410004B18Rik","annotation":"UPF0690 protein C1orf52 homolog; Belongs to the UPF0690 family."},{"id":"ENSMUSP00000076024","abundance":3.33,"rank":6779,"name":"Scaf8","annotation":"SR-related and CTD-associated factor 8; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently  [...] "},{"id":"ENSMUSP00000018918","abundance":3.33,"rank":6780,"name":"Cd68","annotation":"Macrosialin; Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells; Belongs to the LAMP family."},{"id":"ENSMUSP00000048234","abundance":3.33,"rank":6781,"name":"Ick","annotation":"Serine/threonine-protein kinase ICK; Has an essential role in ciliogenesis, particularly in neuronal and retinal progenitor cells. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a role in cardiac development (By similarity). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling -dependent manner and this regulation requires its kinase activity."},{"id":"ENSMUSP00000075463","abundance":3.33,"rank":6782,"name":"Pdgfa","annotation":"Platelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] "},{"id":"ENSMUSP00000096688","abundance":3.33,"rank":6783,"name":"Tsc22d2","annotation":"TSC22 domain family, member 2."},{"id":"ENSMUSP00000106584","abundance":3.33,"rank":6784,"name":"Zscan21","annotation":"Zinc finger and SCAN domain-containing protein 21; Strong transcriptional activator. Associated with meiosis in both male and female gametogenesis. May have different functions in somatic cells; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000100678","abundance":3.33,"rank":6785,"name":"Gm11569","annotation":"Predicted gene 11569."},{"id":"ENSMUSP00000099087","abundance":3.32,"rank":6786,"name":"Adam17","annotation":"Disintegrin and metalloproteinase domain-containing protein 17; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Plays a role in the proteolytic processing of ACE2 (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of [...] "},{"id":"ENSMUSP00000121612","abundance":3.32,"rank":6787,"name":"Aftph","annotation":"Aftiphilin; May play a role in membrane trafficking."},{"id":"ENSMUSP00000033136","abundance":3.32,"rank":6788,"name":"Bag3","annotation":"BAG family molecular chaperone regulator 3; Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport."},{"id":"ENSMUSP00000058375","abundance":3.32,"rank":6789,"name":"Upf2","annotation":"Regulator of nonsense transcripts 2; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA."},{"id":"ENSMUSP00000003857","abundance":3.32,"rank":6790,"name":"Shkbp1","annotation":"SH3KBP1-binding protein 1; Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation."},{"id":"ENSMUSP00000146648","abundance":3.32,"rank":6791,"name":"Lyrm1","annotation":"LYR motif-containing protein 1; May promote cell proliferation and inhibition of apoptosis of preadipocytes."},{"id":"ENSMUSP00000093581","abundance":3.32,"rank":6792,"name":"Armt1","annotation":"Damage-control phosphatase ARMT1; Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (By similarity). Its preference for fructose-1- phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (By similarity). Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues (By similarity). Possibly  [...] "},{"id":"ENSMUSP00000089464","abundance":3.31,"rank":6793,"name":"Net1","annotation":"Neuroepithelial cell-transforming gene 1 protein; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway. Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death."},{"id":"ENSMUSP00000099676","abundance":3.31,"rank":6794,"name":"Tekt2","annotation":"Tektin-2; Structural component of ciliary and flagellar microtubules. Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Belongs to the tektin family."},{"id":"ENSMUSP00000029336","abundance":3.31,"rank":6795,"name":"Dhx36","annotation":"ATP-dependent DNA/RNA helicase DHX36; Multifunctional ATP-dependent helicase that unwinds G- quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses. G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) (By similarity). Plays a role in genomic integrity (By similarity). Converts the G4-RNA structure present in telomerase RNA tem [...] "},{"id":"ENSMUSP00000033430","abundance":3.31,"rank":6796,"name":"Rab33a","annotation":"Ras-related protein Rab-33A; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000110777","abundance":3.31,"rank":6797,"name":"Tnk2","annotation":"Activated CDC42 kinase 1; Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting  [...] "},{"id":"ENSMUSP00000097040","abundance":3.31,"rank":6798,"name":"Slc35d2","annotation":"UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling (By similarity)."},{"id":"ENSMUSP00000073551","abundance":3.31,"rank":6799,"name":"Polg","annotation":"DNA polymerase subunit gamma-1; Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity); Belongs to the DNA polymerase type-A family."},{"id":"ENSMUSP00000104281","abundance":3.31,"rank":6800,"name":"Tfpt","annotation":"TCF3 fusion partner homolog; Appears to promote apoptosis in a p53/TP53-independent manner."},{"id":"ENSMUSP00000113533","abundance":3.31,"rank":6801,"name":"Phkg2","annotation":"Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity)."},{"id":"ENSMUSP00000060646","abundance":3.31,"rank":6802,"name":"Epha5","annotation":"Ephrin type-A receptor 5; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in [...] "},{"id":"ENSMUSP00000001256","abundance":3.31,"rank":6803,"name":"Sema6b","annotation":"Semaphorin-6B."},{"id":"ENSMUSP00000095738","abundance":3.3,"rank":6804,"name":"Ppfibp2","annotation":"Liprin-beta-2; May regulate the disassembly of focal adhesions. Did not bind receptor-like tyrosine phosphatases type 2A (By similarity)."},{"id":"ENSMUSP00000023050","abundance":3.3,"rank":6805,"name":"Tab1","annotation":"TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis."},{"id":"ENSMUSP00000028800","abundance":3.3,"rank":6806,"name":"1700037H04Rik","annotation":"UPF0687 protein C20orf27 homolog; Belongs to the UPF0687 family."},{"id":"ENSMUSP00000073690","abundance":3.3,"rank":6807,"name":"Klf10","annotation":"Krueppel-like factor 10; Transcriptional repressor which binds to the consensus sequence 5'-GGTGTG-3'. May play a role in the cell cycle regulation (By similarity). Plays a role in the regulation of the circadian clock; binds to the GC box sequence in the promoter of the core clock component ARTNL/BMAL1 and represses its transcriptional activity. Regulates the circadian expression of genes involved in lipogenesis, gluconeogenesis, and glycolysis in the liver. Represses the expression of PCK2, a rate-limiting step enzyme of gluconeogenesis. Belongs to the Sp1 C2H2-type zinc-finger prote [...] "},{"id":"ENSMUSP00000046714","abundance":3.3,"rank":6808,"name":"Slc7a1","annotation":"High affinity cationic amino acid transporter 1; High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues."},{"id":"ENSMUSP00000065861","abundance":3.3,"rank":6809,"name":"Zfp580","annotation":"Zinc finger protein 580; Involved in the regulation of endothelial cell proliferation and migration. Mediates H(2)O(2)-induced leukocyte chemotaxis by elevating interleukin-8 production and may play a role in inflammation. May be involved in transcriptional regulation (By similarity)."},{"id":"ENSMUSP00000153073","abundance":3.3,"rank":6810,"name":"Gm49395","annotation":"Predicted gene, 49395."},{"id":"ENSMUSP00000031876","abundance":3.29,"rank":6811,"name":"Stra8","annotation":"Stimulated by retinoic acid gene 8 protein; Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. Can associate with DNA (possibly in an indirect manner), and in vitro can activate DNA transcription."},{"id":"ENSMUSP00000083587","abundance":3.29,"rank":6812,"name":"Icam1","annotation":"Intercellular adhesion molecule 1; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (By similarity)."},{"id":"ENSMUSP00000080739","abundance":3.29,"rank":6813,"name":"Ap3b2","annotation":"AP-3 complex subunit beta-2; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into  [...] "},{"id":"ENSMUSP00000029416","abundance":3.29,"rank":6814,"name":"Ccnl1","annotation":"Cyclin-L1; Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). May play a role in the regulation of RNA polymerase II (pol II). Inhibited by the CDK-specific inhibitor CDKN1A/p21."},{"id":"ENSMUSP00000025522","abundance":3.29,"rank":6815,"name":"Pdgfrb","annotation":"Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at v [...] "},{"id":"ENSMUSP00000113962","abundance":3.29,"rank":6816,"name":"Fam167a","annotation":"Protein FAM167A; Belongs to the FAM167 (SEC) family."},{"id":"ENSMUSP00000056188","abundance":3.29,"rank":6817,"name":"C1ql3","annotation":"Complement C1q-like protein 3; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production."},{"id":"ENSMUSP00000003061","abundance":3.29,"rank":6818,"name":"Bcam","annotation":"Basal cell adhesion molecule; Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity)."},{"id":"ENSMUSP00000022678","abundance":3.29,"rank":6819,"name":"Pebp4","annotation":"Phosphatidylethanolamine-binding protein 4; Seems to promote cellular resistance to TNF-induced apoptosis by inhibiting activation of the Raf-1/MEK/ERK pathway, JNK and phosphatidylethanolamine externalization; Belongs to the phosphatidylethanolamine-binding protein family."},{"id":"ENSMUSP00000044861","abundance":3.29,"rank":6820,"name":"A930018P22Rik","annotation":"Uncharacterized protein C11orf91 homolog."},{"id":"ENSMUSP00000068713","abundance":3.28,"rank":6821,"name":"Nusap1","annotation":"Nucleolar and spindle-associated protein 1; Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them."},{"id":"ENSMUSP00000136728","abundance":3.28,"rank":6822,"name":"Aspn","annotation":"Asporin; Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity (By similarity). Critical regulator of TGF- beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF- beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis o [...] "},{"id":"ENSMUSP00000020339","abundance":3.28,"rank":6823,"name":"Tbc1d15","annotation":"TBC1 domain family member 15; Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6."},{"id":"ENSMUSP00000030475","abundance":3.28,"rank":6824,"name":"Nsun4","annotation":"5-methylcytosine rRNA methyltransferase NSUN4; Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA at position 911; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by  [...] "},{"id":"ENSMUSP00000139481","abundance":3.28,"rank":6825,"name":"Kcna6","annotation":"Potassium voltage-gated channel subfamily A member 6; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient (By similarity). The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (By similarity). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possi [...] "},{"id":"ENSMUSP00000043467","abundance":3.28,"rank":6826,"name":"Dhrs11","annotation":"Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones; Belongs to the short-chain dehydrogenases/reductase [...] "},{"id":"ENSMUSP00000066797","abundance":3.28,"rank":6827,"name":"Rsrc1","annotation":"Serine/Arginine-related protein 53; Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing (By similarity)."},{"id":"ENSMUSP00000137534","abundance":3.28,"rank":6828,"name":"Slc25a19","annotation":"Mitochondrial thiamine pyrophosphate carrier; Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria."},{"id":"ENSMUSP00000135986","abundance":3.28,"rank":6829,"name":"Gpr45","annotation":"Probable G-protein coupled receptor 45; Orphan receptor. May play a role in brain function."},{"id":"ENSMUSP00000048383","abundance":3.27,"rank":6830,"name":"Kif4","annotation":"Chromosome-associated kinesin KIF4; Required for mitotic chromosomal positioning and bipolar spindle stabilization."},{"id":"ENSMUSP00000045608","abundance":3.27,"rank":6831,"name":"Nbl1","annotation":"Neuroblastoma suppressor of tumorigenicity 1; Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process."},{"id":"ENSMUSP00000037900","abundance":3.27,"rank":6832,"name":"Dgkb","annotation":"Diacylglycerol kinase beta; Exhibits high phosphorylation activity for long-chain diacylglycerols."},{"id":"ENSMUSP00000019076","abundance":3.27,"rank":6833,"name":"Map2k3","annotation":"Dual specificity mitogen-activated protein kinase kinase 3; Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily."},{"id":"ENSMUSP00000034369","abundance":3.27,"rank":6834,"name":"Psmb10","annotation":"Proteasome subunit beta type-10; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Plays a role in determining the T-cell repertoire for an antiviral T-cell response; Belongs to the peptidase T1B family."},{"id":"ENSMUSP00000052523","abundance":3.27,"rank":6835,"name":"Pdcd2","annotation":"Programmed cell death protein 2; May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation."},{"id":"ENSMUSP00000103602","abundance":3.27,"rank":6836,"name":"Klk6","annotation":"Kallikrein-related-peptidase 6; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000138305","abundance":3.27,"rank":6837,"name":"Zfp386","annotation":"Zinc finger protein 386 (Kruppel-like) isoform a."},{"id":"ENSMUSP00000006112","abundance":3.27,"rank":6838,"name":"Ephb3","annotation":"Ephrin type-B receptor 3; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and  [...] "},{"id":"ENSMUSP00000105928","abundance":3.27,"rank":6839,"name":"Tgm3","annotation":"Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain; Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cros [...] "},{"id":"ENSMUSP00000047865","abundance":3.27,"rank":6840,"name":"Dhx38","annotation":"DEAH (Asp-Glu-Ala-His) box polypeptide 38."},{"id":"ENSMUSP00000020507","abundance":3.27,"rank":6841,"name":"Fgf18","annotation":"Fibroblast growth factor 18; Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation (By similarity)."},{"id":"ENSMUSP00000081133","abundance":3.27,"rank":6842,"name":"Nol9","annotation":"Polynucleotide 5'-hydroxyl-kinase NOL9; Polynucleotide 5'-kinase involved in rRNA processing. The kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form. In vitro, has both DNA and RNA 5'-kinase activities. Probably binds RNA (By similarity); Belongs to the Clp1 family. NOL9/GRC3 subfamily."},{"id":"ENSMUSP00000130294","abundance":3.27,"rank":6843,"name":"Ctbp2","annotation":"C-terminal-binding protein 2; Corepressor targeting diverse transcription regulators. Isoform 2 probably acts as a scaffold for specialized synapses (By similarity). Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family."},{"id":"ENSMUSP00000096755","abundance":3.27,"rank":6844,"name":"Sox2","annotation":"Transcription factor SOX-2; Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Binds to the proximal enhancer region of NANOG. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarit [...] "},{"id":"ENSMUSP00000074433","abundance":3.26,"rank":6845,"name":"Gm6812","annotation":"Predicted gene 6812."},{"id":"ENSMUSP00000075079","abundance":3.26,"rank":6846,"name":"1700020N15Rik","annotation":"RIKEN cDNA 1700020N15 gene."},{"id":"ENSMUSP00000084487","abundance":3.26,"rank":6847,"name":"Cyp2c66","annotation":"Cytochrome P450, family 2, subfamily c, polypeptide 66; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000031692","abundance":3.26,"rank":6848,"name":"Bcl7b","annotation":"B-cell CLL/lymphoma 7 protein family member B; Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (By similarity). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (By similarity). May play a role in lung tumor development or progression; Belongs to the BCL7 family."},{"id":"ENSMUSP00000071370","abundance":3.26,"rank":6849,"name":"Nhlrc2","annotation":"NHL repeat-containing protein 2; Required for normal embryonic development."},{"id":"ENSMUSP00000033650","abundance":3.26,"rank":6850,"name":"Rs1","annotation":"Retinoschisin; Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides. May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells (By similarity). Required for normal structure and function of the retina."},{"id":"ENSMUSP00000087641","abundance":3.26,"rank":6851,"name":"Dnajb14","annotation":"DnaJ homolog subfamily B member 14; Acts as a co-chaperone with HSPA8/Hsc70; required to promote protein folding and trafficking, prevent aggregation of client proteins, and promote unfolded proteins to endoplasmic reticulum- associated degradation (ERAD) pathway. Acts by determining HSPA8/Hsc70's ATPase and polypeptide-binding activities. Can also act independently of HSPA8/Hsc70: together with DNAJB12, acts as a chaperone that promotes maturation of potassium channels KCND2 and KCNH2 by stabilizing nascent channel subunits and assembling them into tetramers. While stabilization of na [...] "},{"id":"ENSMUSP00000127580","abundance":3.26,"rank":6852,"name":"Dennd1b","annotation":"DENN domain-containing protein 1B; Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP- bound RAB35 into its active GTP-bound form. Plays a role in clathrin- mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregu [...] "},{"id":"ENSMUSP00000022264","abundance":3.26,"rank":6853,"name":"Ptprg","annotation":"Receptor-type tyrosine-protein phosphatase gamma; Possesses tyrosine phosphatase activity."},{"id":"ENSMUSP00000023101","abundance":3.26,"rank":6854,"name":"Slc38a4","annotation":"Sodium-coupled neutral amino acid transporter 4; Sodium-dependent amino acid transporter. Mediates electrogenic symport of neutral amino acids and sodium ions. Has a broad specificity, with a preference for Ala, followed by Ser, His, Gly, Cys, Asn, Thr, Pro, Gln and Met. May mediate sodium-independent transport of cationic amino acids, such as Arg and Lys. Amino acid uptake is pH-dependent, with lower transport activities at pH 6.5, intermediate at pH 7.0 and highest between pH 7.5 and 8.5. Belongs to the amino acid/polyamine transporter 2 family."},{"id":"ENSMUSP00000087961","abundance":3.26,"rank":6855,"name":"Ehf","annotation":"ETS homologous factor; Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes, and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter (By similarity)."},{"id":"ENSMUSP00000110865","abundance":3.25,"rank":6856,"name":"Rhox1","annotation":"Reproductive homeobox 1."},{"id":"ENSMUSP00000105563","abundance":3.25,"rank":6857,"name":"Clmn","annotation":"Calmin."},{"id":"ENSMUSP00000033503","abundance":3.25,"rank":6858,"name":"Glod5","annotation":"Glyoxalase domain-containing protein 5; Belongs to the glyoxalase I family."},{"id":"ENSMUSP00000021714","abundance":3.25,"rank":6859,"name":"Zfyve21","annotation":"Zinc finger FYVE domain-containing protein 21; Plays a role in cell adhesion, and thereby in cell motility which requires repeated formation and disassembly of focal adhesions. Regulates microtubule-induced PTK2/FAK1 dephosphorylation, an event important for focal adhesion disassembly, as well as integrin beta- 1/ITGB1 cell surface expression (By similarity)."},{"id":"ENSMUSP00000135223","abundance":3.25,"rank":6860,"name":"Cux1","annotation":"Homeobox protein cut-like 1; Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis (Probable). In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunogl [...] "},{"id":"ENSMUSP00000030901","abundance":3.25,"rank":6861,"name":"Ints11","annotation":"Integrator complex subunit 11; Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactam [...] "},{"id":"ENSMUSP00000029719","abundance":3.25,"rank":6862,"name":"Dclk2","annotation":"Serine/threonine-protein kinase DCLK2; Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm."},{"id":"ENSMUSP00000088369","abundance":3.25,"rank":6863,"name":"Hrnr","annotation":"Hornerin; Component of the epidermal cornified cell envelopes; Belongs to the S100-fused protein family."},{"id":"ENSMUSP00000031324","abundance":3.25,"rank":6864,"name":"Ereg","annotation":"Proepiregulin; Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (By similarity). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation."},{"id":"ENSMUSP00000045693","abundance":3.25,"rank":6865,"name":"Cobl","annotation":"Protein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells."},{"id":"ENSMUSP00000112699","abundance":3.25,"rank":6866,"name":"Mybpc1","annotation":"Myosin-binding protein C, slow-type."},{"id":"ENSMUSP00000123266","abundance":3.24,"rank":6867,"name":"Rasal1","annotation":"RasGAP-activating-like protein 1; Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes."},{"id":"ENSMUSP00000153311","abundance":3.24,"rank":6868,"name":"Gas1","annotation":"Growth arrest-specific protein 1; Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells."},{"id":"ENSMUSP00000057632","abundance":3.24,"rank":6869,"name":"Ppip5k1","annotation":"Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylate [...] "},{"id":"ENSMUSP00000147681","abundance":3.24,"rank":6870,"name":"Gm17949","annotation":"Predicted gene, 17949; Belongs to the adenylate kinase family."},{"id":"ENSMUSP00000128914","abundance":3.24,"rank":6871,"name":"Os9","annotation":"Protein OS-9; Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 (By similarity); Belongs to the OS-9 family."},{"id":"ENSMUSP00000107695","abundance":3.24,"rank":6872,"name":"Cacna1s","annotation":"Voltage-dependent L-type calcium channel subunit alpha-1S; Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group."},{"id":"ENSMUSP00000127385","abundance":3.24,"rank":6873,"name":"Commd3","annotation":"COMM domain-containing protein 3; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits."},{"id":"ENSMUSP00000126603","abundance":3.24,"rank":6874,"name":"Ggps1","annotation":"Geranylgeranyl pyrophosphate synthase; Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins; Belongs to the FPP/GGPP synthase family."},{"id":"ENSMUSP00000058283","abundance":3.23,"rank":6875,"name":"Timm29","annotation":"Mitochondrial import inner membrane translocase subunit Tim29; Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. Required for the stability of the TIM22 complex and functions in the assembly of the TIMM22 protein into the TIM22 complex. May facilitate cooperation between TIM22 and TOM complexes by interacting with TOMM40."},{"id":"ENSMUSP00000108207","abundance":3.23,"rank":6876,"name":"Kdm5c","annotation":"Lysine-specific demethylase 5C; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock comp [...] "},{"id":"ENSMUSP00000024742","abundance":3.23,"rank":6877,"name":"Nfkbie","annotation":"NF-kappa-B inhibitor epsilon; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. Inhibits DNA-binding of NF-kappa-B p50-p65 and p50-c-Rel complexes (By similarity)."},{"id":"ENSMUSP00000089517","abundance":3.23,"rank":6878,"name":"Sh3bp5","annotation":"SH3 domain-binding protein 5; Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (By similarity). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death."},{"id":"ENSMUSP00000045807","abundance":3.23,"rank":6879,"name":"Phyhipl","annotation":"Phytanoyl-CoA hydroxylase-interacting protein-like; May play a role in the development of the central system. Belongs to the PHYHIP family."},{"id":"ENSMUSP00000123853","abundance":3.23,"rank":6880,"name":"Gcsam","annotation":"Germinal center-associated signaling and motility protein; Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation."},{"id":"ENSMUSP00000046824","abundance":3.23,"rank":6881,"name":"Tekt5","annotation":"Tektin-5; May be a structural component of the sperm flagellum."},{"id":"ENSMUSP00000069011","abundance":3.23,"rank":6882,"name":"Pde5a","annotation":"cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP."},{"id":"ENSMUSP00000032066","abundance":3.23,"rank":6883,"name":"Tgfa","annotation":"Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar."},{"id":"ENSMUSP00000060323","abundance":3.23,"rank":6884,"name":"4933428G20Rik","annotation":"RIKEN cDNA 4933428G20 gene."},{"id":"ENSMUSP00000005669","abundance":3.23,"rank":6885,"name":"Cyp2b13","annotation":"Cytochrome P450, family 2, subfamily b, polypeptide 13; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000045216","abundance":3.23,"rank":6886,"name":"Slc16a1","annotation":"Monocarboxylate transporter 1; Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to [...] "},{"id":"ENSMUSP00000106865","abundance":3.22,"rank":6887,"name":"Tnfrsf19","annotation":"Tumor necrosis factor receptor superfamily member 19; Can mediate activation of c-Jun and NF-kappa-B. May promote caspase-independent cell death (By similarity). Isoform 2 and isoform 3 may act as decoy receptors."},{"id":"ENSMUSP00000029653","abundance":3.22,"rank":6888,"name":"Egf","annotation":"Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity)."},{"id":"ENSMUSP00000064714","abundance":3.22,"rank":6889,"name":"Slc8b1","annotation":"Mitochondrial sodium/calcium exchanger protein; Mitochondrial sodium/calcium antiporter that mediates sodium- dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes. Regulates rates of glucose- dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mit [...] "},{"id":"ENSMUSP00000022921","abundance":3.22,"rank":6890,"name":"Angpt1","annotation":"Angiopoietin-1; Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells [...] "},{"id":"ENSMUSP00000041851","abundance":3.22,"rank":6891,"name":"Dars2","annotation":"Aspartate--tRNA ligase, mitochondrial."},{"id":"ENSMUSP00000042159","abundance":3.22,"rank":6892,"name":"Cpne7","annotation":"Copine-7; Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes."},{"id":"ENSMUSP00000106151","abundance":3.22,"rank":6893,"name":"Trim9","annotation":"E3 ubiquitin-protein ligase TRIM9; E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000038263","abundance":3.22,"rank":6894,"name":"Noc4l","annotation":"Nucleolar complex protein 4 homolog."},{"id":"ENSMUSP00000028259","abundance":3.21,"rank":6895,"name":"Ifih1","annotation":"Interferon-induced helicase C domain-containing protein 1; Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long- dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylat [...] "},{"id":"ENSMUSP00000093436","abundance":3.21,"rank":6896,"name":"Trdn","annotation":"Triadin; Contributes to the regulation of lumenal Ca2+ release via the sarcoplasmic reticulum calcium release channels RYR1 and RYR2, a key step in triggering skeletal and heart muscle contraction. Required for normal organization of the triad junction, where T-tubules and the sarcoplasmic reticulum terminal cisternae are in close contact. Required for normal skeletal muscle strength. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats."},{"id":"ENSMUSP00000149762","abundance":3.21,"rank":6897,"name":"Olfr305","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000060671","abundance":3.21,"rank":6898,"name":"Tead1","annotation":"Transcriptional enhancer factor TEF-1; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] "},{"id":"ENSMUSP00000108481","abundance":3.21,"rank":6899,"name":"Zfp637","annotation":"Zinc finger protein 32; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000105409","abundance":3.21,"rank":6900,"name":"Zmiz2","annotation":"Zinc finger MIZ domain-containing protein 2; Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors."},{"id":"ENSMUSP00000020695","abundance":3.21,"rank":6901,"name":"Tns3","annotation":"Tensin-3; May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration (By similarity). May be involved in cell migration and bone development."},{"id":"ENSMUSP00000088334","abundance":3.2,"rank":6902,"name":"Map3k20","annotation":"Mitogen-activated protein kinase kinase kinase 20; Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14 (By similarity). Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (By similarity). Involved in limb development."},{"id":"ENSMUSP00000045647","abundance":3.2,"rank":6903,"name":"Ybey","annotation":"Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in rRNA maturation; Belongs to the endoribonuclease YbeY family."},{"id":"ENSMUSP00000135877","abundance":3.2,"rank":6904,"name":"Prh1","annotation":"Proline-rich protein HaeIII subfamily 1."},{"id":"ENSMUSP00000088333","abundance":3.2,"rank":6905,"name":"Sema6c","annotation":"Semaphorin-6C; May be a stop signal for the dorsal root ganglion neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections (By similarity); Belongs to the semaphorin family."},{"id":"ENSMUSP00000151931","abundance":3.2,"rank":6906,"name":"Prdm4","annotation":"PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation; Belongs to the class V-like SAM-binding methyltransferase superfamily."},{"id":"ENSMUSP00000034147","abundance":3.2,"rank":6907,"name":"Zfp330","annotation":"Zinc finger protein 330; Belongs to the NOA36 family."},{"id":"ENSMUSP00000028749","abundance":3.2,"rank":6908,"name":"Capn3","annotation":"Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family."},{"id":"ENSMUSP00000118452","abundance":3.2,"rank":6909,"name":"Adgrl1","annotation":"Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity); Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily."},{"id":"ENSMUSP00000019067","abundance":3.2,"rank":6910,"name":"Med11","annotation":"Mediator of RNA polymerase II transcription subunit 11; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000108666","abundance":3.2,"rank":6911,"name":"Pwwp3b","annotation":"PWWP domain-containing DNA repair factor 3B; Belongs to the PWWP3A family."},{"id":"ENSMUSP00000106746","abundance":3.19,"rank":6912,"name":"Cdc42bpa","annotation":"Serine/threonine-protein kinase MRCK alpha; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LRP35A, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A and LIMK2. May play a role in TFRC-mediated iron uptake (By similarity). In concert with FAM89B/LRAP25 mediates the  [...] "},{"id":"ENSMUSP00000002112","abundance":3.19,"rank":6913,"name":"Trappc6a","annotation":"Trafficking protein particle complex subunit 6A; May play a role in vesicular transport during the biogenesis of melanosomes."},{"id":"ENSMUSP00000113154","abundance":3.19,"rank":6914,"name":"Gm2012","annotation":"Predicted gene 2012."},{"id":"ENSMUSP00000037958","abundance":3.19,"rank":6915,"name":"Kcna4","annotation":"Potassium voltage-gated channel subfamily A member 4; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well [...] "},{"id":"ENSMUSP00000026750","abundance":3.18,"rank":6916,"name":"Cnksr2","annotation":"Connector enhancer of kinase suppressor of ras 2; May function as an adapter protein or regulator of Ras signaling pathways; Belongs to the CNKSR family."},{"id":"ENSMUSP00000063882","abundance":3.18,"rank":6917,"name":"Lrtm2","annotation":"Leucine-rich repeat and transmembrane domain-containing protein 2."},{"id":"ENSMUSP00000079468","abundance":3.18,"rank":6918,"name":"Scgb1b2","annotation":"Lacrimal androgen-binding protein eta."},{"id":"ENSMUSP00000115869","abundance":3.18,"rank":6919,"name":"Prpf40b","annotation":"Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing; Belongs to the PRPF40 family."},{"id":"ENSMUSP00000050237","abundance":3.18,"rank":6920,"name":"Fam221a","annotation":"Protein FAM221A."},{"id":"ENSMUSP00000028306","abundance":3.18,"rank":6921,"name":"Lcn5","annotation":"Epididymal-specific lipocalin-5, major form; Associates with spermatozoa in the epididymal fluid but does not bind tightly to them. Binds both all-trans and 13-cis retinoic acid. May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation. Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000108263","abundance":3.18,"rank":6922,"name":"3110009E18Rik","annotation":"UPF0538 protein C2orf76 homolog."},{"id":"ENSMUSP00000030074","abundance":3.18,"rank":6923,"name":"Ugcg","annotation":"Ceramide glucosyltransferase; Catalyzes at the cytosolic surface of the Golgi, the initial step of the glucosylceramide-based glycosphingolipid/GSL synthetic pathway, the transfer of glucose from UDP-glucose to ceramide to produce glucosylceramide/GlcCer. Glucosylceramide is the core component of glycosphingolipids/GSLs, amphipathic molecules consisting of a ceramide lipid moiety embedded in the outer leaflet of the membrane, linked to one of hundreds of different externally oriented oligosaccharide structures. Glycosphingolipids are essential components of membrane microdomains that m [...] "},{"id":"ENSMUSP00000125122","abundance":3.18,"rank":6924,"name":"A530032D15Rik","annotation":"RIKEN cDNA A530032D15Rik gene."},{"id":"ENSMUSP00000026672","abundance":3.18,"rank":6925,"name":"Pde8a","annotation":"High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser- 259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF- activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine."},{"id":"ENSMUSP00000030471","abundance":3.17,"rank":6926,"name":"Lrrc41","annotation":"Leucine-rich repeat-containing protein 41; Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins."},{"id":"ENSMUSP00000033769","abundance":3.17,"rank":6927,"name":"Irak1","annotation":"Interleukin-1 receptor-associated kinase 1; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquit [...] "},{"id":"ENSMUSP00000140409","abundance":3.17,"rank":6928,"name":"Spock1","annotation":"Testican-1; May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system."},{"id":"ENSMUSP00000045239","abundance":3.17,"rank":6929,"name":"Golgb1","annotation":"Golgi autoantigen, golgin subfamily b, macrogolgin 1."},{"id":"ENSMUSP00000151677","abundance":3.17,"rank":6930,"name":"Hamp2","annotation":"Hepcidin-2; Seems to act as a signaling molecule involved in the maintenance of iron homeostasis."},{"id":"ENSMUSP00000100677","abundance":3.17,"rank":6931,"name":"Gm11554","annotation":"Predicted gene 11554."},{"id":"ENSMUSP00000090027","abundance":3.17,"rank":6932,"name":"Enpp7","annotation":"Ectonucleotide pyrophosphatase/phosphodiesterase 7."},{"id":"ENSMUSP00000059420","abundance":3.17,"rank":6933,"name":"Foxo4","annotation":"Forkhead box protein O4; Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity (By similarity). R [...] "},{"id":"ENSMUSP00000151792","abundance":3.17,"rank":6934,"name":"Gm32717","annotation":"Predicted gene, 32717."},{"id":"ENSMUSP00000151607","abundance":3.17,"rank":6935,"name":"Gm32802","annotation":"Predicted gene, 32717."},{"id":"ENSMUSP00000108562","abundance":3.17,"rank":6936,"name":"Pdcl","annotation":"Phosducin-like protein; Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function ; Belongs to the phosducin family."},{"id":"ENSMUSP00000063054","abundance":3.17,"rank":6937,"name":"Rab33b","annotation":"Ras-related protein Rab-33B; Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000021183","abundance":3.17,"rank":6938,"name":"Eral1","annotation":"GTPase Era, mitochondrial; Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity); Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family."},{"id":"ENSMUSP00000049070","abundance":3.17,"rank":6939,"name":"Tulp1","annotation":"Tubby-related protein 1; Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4- bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro) (By similari [...] "},{"id":"ENSMUSP00000020190","abundance":3.17,"rank":6940,"name":"Vnn3","annotation":"Vascular non-inflammatory molecule 3; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine; Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family."},{"id":"ENSMUSP00000108744","abundance":3.17,"rank":6941,"name":"Brpf1","annotation":"Peregrin; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Preferentially mediates histone H3-K23 acetylation. Positively regulates the transcription of RUNX1 and RUNX2 (By similarity)."},{"id":"ENSMUSP00000042772","abundance":3.17,"rank":6942,"name":"Ccdc114","annotation":"Coiled-coil domain-containing protein 114; Probable component of the outer dynein arm complex required along the entire axoneme for tethering of outer dynein arms. Belongs to the ODA1/DCC2 family."},{"id":"ENSMUSP00000099842","abundance":3.17,"rank":6943,"name":"Jak1","annotation":"Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor."},{"id":"ENSMUSP00000104046","abundance":3.17,"rank":6944,"name":"Tmem145","annotation":"Transmembrane protein 145."},{"id":"ENSMUSP00000135398","abundance":3.16,"rank":6945,"name":"Glmp","annotation":"Glycosylated lysosomal membrane protein."},{"id":"ENSMUSP00000042565","abundance":3.16,"rank":6946,"name":"Cdc42bpb","annotation":"Serine/threonine-protein kinase MRCK beta; Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A (By similarity). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its a [...] "},{"id":"ENSMUSP00000139181","abundance":3.16,"rank":6947,"name":"Atf7","annotation":"Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family (By similarity)."},{"id":"ENSMUSP00000033899","abundance":3.16,"rank":6948,"name":"Col4a2","annotation":"Collagen alpha-2(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen."},{"id":"ENSMUSP00000036614","abundance":3.16,"rank":6949,"name":"Bloc1s5","annotation":"Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking."},{"id":"ENSMUSP00000114223","abundance":3.16,"rank":6950,"name":"Tbpl1","annotation":"TATA box-binding protein-like protein 1; Part of a specialized transcription system that mediates the transcription of most ribosomal proteins through the 5'-TCT-3' motif which is a core promoter element at these genes (By similarity). Seems to also mediate the transcription of NF1. Does not bind the TATA box."},{"id":"ENSMUSP00000036721","abundance":3.16,"rank":6951,"name":"Atcay","annotation":"Caytaxin; Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites."},{"id":"ENSMUSP00000022462","abundance":3.16,"rank":6952,"name":"Oxnad1","annotation":"Oxidoreductase NAD-binding domain-containing protein 1."},{"id":"ENSMUSP00000090360","abundance":3.16,"rank":6953,"name":"Nt5c3b","annotation":"7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity)."},{"id":"ENSMUSP00000126303","abundance":3.16,"rank":6954,"name":"Mgat1","annotation":"Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans."},{"id":"ENSMUSP00000077301","abundance":3.15,"rank":6955,"name":"Dynlrb2","annotation":"Dynein light chain roadblock-type 2; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules; Belongs to the GAMAD family."},{"id":"ENSMUSP00000024627","abundance":3.15,"rank":6956,"name":"Chd1","annotation":"Chromodomain-helicase-DNA-binding protein 1; ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Required for the bridg [...] "},{"id":"ENSMUSP00000109673","abundance":3.15,"rank":6957,"name":"Gm14744","annotation":"Predicted gene 14744; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000052804","abundance":3.15,"rank":6958,"name":"5430402E10Rik","annotation":"RIKEN cDNA 5430402E10 gene; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000072617","abundance":3.15,"rank":6959,"name":"Hsf1","annotation":"Heat shock factor protein 1; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non- DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcriptio [...] "},{"id":"ENSMUSP00000112666","abundance":3.15,"rank":6960,"name":"Akr1c19","annotation":"Aldo-keto reductase family 1, member C19."},{"id":"ENSMUSP00000126496","abundance":3.15,"rank":6961,"name":"Fam71f1","annotation":"Protein FAM71F1; Belongs to the FAM71 family."},{"id":"ENSMUSP00000057461","abundance":3.15,"rank":6962,"name":"C87436","annotation":"Uncharacterized protein C2orf42 homolog."},{"id":"ENSMUSP00000025639","abundance":3.15,"rank":6963,"name":"Ccdc86","annotation":"Coiled-coil domain-containing protein 86."},{"id":"ENSMUSP00000057722","abundance":3.15,"rank":6964,"name":"Cpa5","annotation":"Carboxypeptidase A5."},{"id":"ENSMUSP00000077099","abundance":3.14,"rank":6965,"name":"Dock10","annotation":"Dedicator of cytokinesis protein 10; Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression."},{"id":"ENSMUSP00000047398","abundance":3.14,"rank":6966,"name":"Setd5","annotation":"Histone-lysine N-methyltransferase SETD5; Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 in vitro. The physiological significance of this activity is unclear (Probable). Probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. Acts as a regulator of histone acetylation during gene transcription."},{"id":"ENSMUSP00000115381","abundance":3.14,"rank":6967,"name":"Gm28305","annotation":"Predicted gene 28305."},{"id":"ENSMUSP00000035045","abundance":3.14,"rank":6968,"name":"Mras","annotation":"Ras-related protein M-Ras; Serves as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Activates the MAP kinase pathway (By similarity)."},{"id":"ENSMUSP00000041563","abundance":3.14,"rank":6969,"name":"Fam110c","annotation":"Protein FAM110C; May play a role in microtubule organization. May play a role in cell spreading and cell migration of epithelial cells; the function may involve the AKT1 signaling pathway."},{"id":"ENSMUSP00000025691","abundance":3.14,"rank":6970,"name":"Fas","annotation":"Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity)."},{"id":"ENSMUSP00000109838","abundance":3.14,"rank":6971,"name":"Fam219b","annotation":"Protein FAM219B."},{"id":"ENSMUSP00000098828","abundance":3.14,"rank":6972,"name":"Tbc1d9b","annotation":"TBC1 domain family member 9B; May act as a GTPase-activating protein for Rab family protein(s)."},{"id":"ENSMUSP00000080179","abundance":3.14,"rank":6973,"name":"Lgals7","annotation":"Galectin-7; Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release (By similarity)."},{"id":"ENSMUSP00000041650","abundance":3.13,"rank":6974,"name":"Commd10","annotation":"COMM domain-containing protein 10; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B."},{"id":"ENSMUSP00000074447","abundance":3.13,"rank":6975,"name":"Borcs7","annotation":"BLOC-1-related complex subunit 7; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor."},{"id":"ENSMUSP00000152946","abundance":3.13,"rank":6976,"name":"Mak","annotation":"Serine/threonine-protein kinase MAK; Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors. Could have an important function in sensory cells and in spermatogenesis. May participate in signaling pathways used in visual and olfactory sensory transduction. Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR (By similarity)."},{"id":"ENSMUSP00000108584","abundance":3.13,"rank":6977,"name":"Lhx6","annotation":"LIM/homeobox protein Lhx6; Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex."},{"id":"ENSMUSP00000024831","abundance":3.13,"rank":6978,"name":"Tff1","annotation":"Trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents."},{"id":"ENSMUSP00000065468","abundance":3.13,"rank":6979,"name":"Nyap2","annotation":"Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Belongs to the NYAP family."},{"id":"ENSMUSP00000030731","abundance":3.13,"rank":6980,"name":"Taf12","annotation":"Transcription initiation factor TFIID subunit 12; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription (By similarity)."},{"id":"ENSMUSP00000106866","abundance":3.13,"rank":6981,"name":"Igsf9","annotation":"Protein turtle homolog A; Functions in dendrite outgrowth and synapse maturation."},{"id":"ENSMUSP00000062903","abundance":3.13,"rank":6982,"name":"Speer4b","annotation":"Spermatogenesis associated glutamate (E)-rich protein 4b."},{"id":"ENSMUSP00000050353","abundance":3.13,"rank":6983,"name":"Runx3","annotation":"Runt-related transcription factor 3; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T [...] "},{"id":"ENSMUSP00000072894","abundance":3.13,"rank":6984,"name":"Peli2","annotation":"E3 ubiquitin-protein ligase pellino homolog 2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL- 1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3- dependent, NF-kappa-B activation. Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1."},{"id":"ENSMUSP00000056555","abundance":3.12,"rank":6985,"name":"Fam43a","annotation":"Protein FAM43A; Belongs to the FAM43 family."},{"id":"ENSMUSP00000082011","abundance":3.12,"rank":6986,"name":"Trmt61a","annotation":"tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A; Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Catalytic subunit of mRNA N(1)- methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries."},{"id":"ENSMUSP00000076160","abundance":3.12,"rank":6987,"name":"Cop1","annotation":"E3 ubiquitin-protein ligase COP1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in JUN ubiquitination and degradation. Directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity  [...] "},{"id":"ENSMUSP00000029307","abundance":3.12,"rank":6988,"name":"Stoml3","annotation":"Stomatin-like protein 3; Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations."},{"id":"ENSMUSP00000034522","abundance":3.12,"rank":6989,"name":"Clmp","annotation":"CXADR-like membrane protein; May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development (By similarity)."},{"id":"ENSMUSP00000033783","abundance":3.12,"rank":6990,"name":"Tceal6","annotation":"Transcription elongation factor A (SII)-like 6."},{"id":"ENSMUSP00000108724","abundance":3.12,"rank":6991,"name":"Tceal3","annotation":"Transcription elongation factor A protein-like 3; May be involved in transcriptional regulation; Belongs to the TFS-II family. TFA subfamily."},{"id":"ENSMUSP00000085263","abundance":3.12,"rank":6992,"name":"Cbln4","annotation":"Cerebellin-4; Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for the formation and maintenance of inhibitory GABAergic synapses. Promotes the development of dendrite-targeting inhibitory GABAergic synapses made by somatostatin-positive interneurons. May contribute to the function of ventral medial habenula region of the brain implicated in the regulation of anxiety-related behaviors. May play a role in CBLN3 export from the endoplasmic reticulum and secretion."},{"id":"ENSMUSP00000071630","abundance":3.12,"rank":6993,"name":"Zfp36l3","annotation":"mRNA decay activator protein ZFP36L3; Placenta-specific zinc-finger RNA-binding protein that destabilizes cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Binds to the 3'-UTR ARE of placental target mRNAs, such as TNF, HBEGF and LIPG. Involved in placental expression of many genes important for normal placental physiology."},{"id":"ENSMUSP00000032768","abundance":3.12,"rank":6994,"name":"Nr2f2","annotation":"COUP transcription factor 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A (By similarity)."},{"id":"ENSMUSP00000107458","abundance":3.12,"rank":6995,"name":"Slco1a6","annotation":"Solute carrier organic anion transporter family member 1A6; May mediate the Na(+)-independent transport of organic anions; Belongs to the organo anion transporter (TC 2.A.60) family."},{"id":"ENSMUSP00000070200","abundance":3.12,"rank":6996,"name":"Adra1b","annotation":"Alpha-1B adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity)."},{"id":"ENSMUSP00000099621","abundance":3.12,"rank":6997,"name":"Rpa2","annotation":"Replication protein A 32 kDa subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRI [...] "},{"id":"ENSMUSP00000131308","abundance":3.12,"rank":6998,"name":"Slc17a3","annotation":"Solute carrier family 17 (sodium phosphate), member 3."},{"id":"ENSMUSP00000102491","abundance":3.12,"rank":6999,"name":"Olfr69","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000028360","abundance":3.12,"rank":7000,"name":"Il1f5","annotation":"Interleukin-36 receptor antagonist protein; Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recru [...] "},{"id":"ENSMUSP00000086714","abundance":3.12,"rank":7001,"name":"Npcd","annotation":"Neuronal pentraxin chromo domain."},{"id":"ENSMUSP00000150493","abundance":3.11,"rank":7002,"name":"Olfr68","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000106199","abundance":3.11,"rank":7003,"name":"Map4k5","annotation":"Mitogen-activated protein kinase kinase kinase kinase 5; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity)."},{"id":"ENSMUSP00000051618","abundance":3.11,"rank":7004,"name":"Rai2","annotation":"Retinoic acid-induced protein 2."},{"id":"ENSMUSP00000030243","abundance":3.11,"rank":7005,"name":"Prkaa2","annotation":"5'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] "},{"id":"ENSMUSP00000104548","abundance":3.11,"rank":7006,"name":"Irf1","annotation":"Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] "},{"id":"ENSMUSP00000074969","abundance":3.11,"rank":7007,"name":"Brsk2","annotation":"Serine/threonine-protein kinase BRSK2; Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to  [...] "},{"id":"ENSMUSP00000038653","abundance":3.11,"rank":7008,"name":"Iqsec3","annotation":"IQ motif and SEC7 domain-containing protein 3; Acts as a guanine nucleotide exchange factor (GEF) for ARF1. Belongs to the BRAG family."},{"id":"ENSMUSP00000131734","abundance":3.11,"rank":7009,"name":"Dhx37","annotation":"DEAH (Asp-Glu-Ala-His) box polypeptide 37."},{"id":"ENSMUSP00000049116","abundance":3.11,"rank":7010,"name":"Alkbh5","annotation":"RNA demethylase ALKBH5; Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (By similarity). Requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). Demethylation of m6A mRNA affects mRNA processing and export (By similarity). Required for the late meiotic and haploid phases of spermatogenesis by mediating m6A demethylation in spermatocytes a [...] "},{"id":"ENSMUSP00000129220","abundance":3.11,"rank":7011,"name":"Myo9b","annotation":"Unconventional myosin-IXb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activator for RHOA. Plays a role in the regulation of cell migration via its role as RHOA GTPase activator. This is regulated by its interaction with the SLIT2 receptor ROBO1; interaction with ROBO1 impairs interaction with RHOA and subsequent activation of RHOA GTPase activity, and thereb [...] "},{"id":"ENSMUSP00000059304","abundance":3.11,"rank":7012,"name":"Tefm","annotation":"Transcription elongation factor, mitochondrial; Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery (By similarity)."},{"id":"ENSMUSP00000123872","abundance":3.1,"rank":7013,"name":"Ear10","annotation":"Eosinophil-associated, ribonuclease A family, member 10; Belongs to the pancreatic ribonuclease family."},{"id":"ENSMUSP00000042882","abundance":3.1,"rank":7014,"name":"Mrm3","annotation":"rRNA methyltransferase 3, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA."},{"id":"ENSMUSP00000101269","abundance":3.1,"rank":7015,"name":"Trp73","annotation":"Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein."},{"id":"ENSMUSP00000062887","abundance":3.1,"rank":7016,"name":"Morn4","annotation":"MORN repeat-containing protein 4; Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma."},{"id":"ENSMUSP00000145948","abundance":3.1,"rank":7017,"name":"Exosc5","annotation":"Exosome complex component RRP46; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] "},{"id":"ENSMUSP00000048319","abundance":3.1,"rank":7018,"name":"Orc3","annotation":"Origin recognition complex subunit 3; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3."},{"id":"ENSMUSP00000092538","abundance":3.1,"rank":7019,"name":"Usp24","annotation":"Ubiquitin carboxyl-terminal hydrolase 24; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation (By similarity)."},{"id":"ENSMUSP00000032924","abundance":3.1,"rank":7020,"name":"Kctd13","annotation":"BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission ; Belongs to the BACURD family."},{"id":"ENSMUSP00000151751","abundance":3.1,"rank":7021,"name":"Slc25a21","annotation":"Mitochondrial 2-oxodicarboxylate carrier; Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2- aminoadipate, oxaloacetate, and citrate (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000125312","abundance":3.09,"rank":7022,"name":"Exoc6b","annotation":"Exocyst complex component 6B; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane."},{"id":"ENSMUSP00000000129","abundance":3.09,"rank":7023,"name":"Fer","annotation":"Tyrosine-protein kinase Fer; Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF- kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream o [...] "},{"id":"ENSMUSP00000108184","abundance":3.09,"rank":7024,"name":"Samt1d","annotation":"Spermatogenesis-associated multipass transmembrane protein 1d."},{"id":"ENSMUSP00000137533","abundance":3.09,"rank":7025,"name":"Samt1b","annotation":"Spermatogenesis associated multipass transmembrane protein 1b."},{"id":"ENSMUSP00000137062","abundance":3.09,"rank":7026,"name":"Samt1","annotation":"Spermatogenesis associated multipass transmembrane protein 1."},{"id":"ENSMUSP00000116409","abundance":3.09,"rank":7027,"name":"Samt1c","annotation":"Spermatogenesis-associated multipass transmembrane protein 1b."},{"id":"ENSMUSP00000125622","abundance":3.09,"rank":7028,"name":"Srgn","annotation":"Serglycin; Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule- mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also r [...] "},{"id":"ENSMUSP00000141397","abundance":3.09,"rank":7029,"name":"Gm5150","annotation":"SIRP beta 1 like 1 protein."},{"id":"ENSMUSP00000145462","abundance":3.09,"rank":7030,"name":"Skap2","annotation":"Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. Belongs to the SKAP family."},{"id":"ENSMUSP00000025827","abundance":3.09,"rank":7031,"name":"Minpp1","annotation":"Multiple inositol polyphosphate phosphatase 1; Acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate (By similarity). Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity [...] "},{"id":"ENSMUSP00000007161","abundance":3.09,"rank":7032,"name":"Klk4","annotation":"Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix."},{"id":"ENSMUSP00000116249","abundance":3.09,"rank":7033,"name":"Bfsp2","annotation":"Phakinin; Required for the correct formation and organization of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA."},{"id":"ENSMUSP00000023776","abundance":3.09,"rank":7034,"name":"Slc4a8","annotation":"Electroneutral sodium bicarbonate exchanger 1; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity."},{"id":"ENSMUSP00000042509","abundance":3.09,"rank":7035,"name":"Wdr48","annotation":"WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate."},{"id":"ENSMUSP00000141094","abundance":3.09,"rank":7036,"name":"Ppp1r18","annotation":"Phostensin; May target protein phosphatase 1 to F-actin cytoskeleton."},{"id":"ENSMUSP00000074533","abundance":3.09,"rank":7037,"name":"Helz","annotation":"Probable helicase with zinc finger domain; May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo."},{"id":"ENSMUSP00000103060","abundance":3.09,"rank":7038,"name":"Krtap4-16","annotation":"Keratin associated protein 4-16."},{"id":"ENSMUSP00000112982","abundance":3.09,"rank":7039,"name":"Gm4985","annotation":"Predicted gene 4985."},{"id":"ENSMUSP00000112673","abundance":3.09,"rank":7040,"name":"Tsks","annotation":"Testis-specific serine kinase substrate; May play a role in testicular physiology, most probably in the process of spermatogenesis or spermatid development."},{"id":"ENSMUSP00000132963","abundance":3.08,"rank":7041,"name":"Cd2bp2","annotation":"CD2 antigen cytoplasmic tail-binding protein 2; Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly."},{"id":"ENSMUSP00000039027","abundance":3.08,"rank":7042,"name":"Tsr1","annotation":"Pre-rRNA-processing protein TSR1 homolog; Required during maturation of the 40S ribosomal subunit in the nucleolus."},{"id":"ENSMUSP00000063461","abundance":3.08,"rank":7043,"name":"Slc35c1","annotation":"GDP-fucose transporter 1; Involved in GDP-fucose import from the cytoplasm into the Golgi lumen; Belongs to the TPT transporter family. SLC35C subfamily."},{"id":"ENSMUSP00000034561","abundance":3.08,"rank":7044,"name":"Alg9","annotation":"Alpha-1,2-mannosyltransferase ALG9; Catalyzes the transfer of mannose from Dol-P-Man to lipid- linked oligosaccharides."},{"id":"ENSMUSP00000028999","abundance":3.08,"rank":7045,"name":"Pkia","annotation":"cAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains; Belongs to the PKI family."},{"id":"ENSMUSP00000040255","abundance":3.08,"rank":7046,"name":"Aoc2","annotation":"Retina-specific copper amine oxidase; Has a monoamine oxidase activity with substrate specificity for 2-phenylethylamine and tryptamine. May play a role in adipogenesis. May be a critical modulator of signal transmission in retina (By similarity); Belongs to the copper/topaquinone oxidase family."},{"id":"ENSMUSP00000081020","abundance":3.08,"rank":7047,"name":"Selenoo","annotation":"Protein adenylyltransferase SelO, mitochondrial; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein; Belongs to the SELO family."},{"id":"ENSMUSP00000051389","abundance":3.07,"rank":7048,"name":"Akap8l","annotation":"A-kinase anchor protein 8-like; Could play a role in constitutive transport element (CTE)- mediated gene expression by association with DHX9. Increases CTE- dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associate [...] "},{"id":"ENSMUSP00000035588","abundance":3.07,"rank":7049,"name":"Oas3","annotation":"2'-5'-oligoadenylate synthase 3; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibi [...] "},{"id":"ENSMUSP00000070778","abundance":3.07,"rank":7050,"name":"Pgpep1","annotation":"Pyroglutamyl-peptidase 1; Removes 5-oxoproline from various penultimate amino acid residues except L-proline; Belongs to the peptidase C15 family."},{"id":"ENSMUSP00000045812","abundance":3.07,"rank":7051,"name":"Pwp2","annotation":"Periodic tryptophan protein 2 homolog."},{"id":"ENSMUSP00000047950","abundance":3.07,"rank":7052,"name":"Cdc16","annotation":"Cell division cycle protein 16 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)."},{"id":"ENSMUSP00000030274","abundance":3.07,"rank":7053,"name":"Bend5","annotation":"BEN domain-containing protein 5; Acts as a transcriptional repressor."},{"id":"ENSMUSP00000072481","abundance":3.07,"rank":7054,"name":"Tle1","annotation":"Transducin-like enhancer protein 1; Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full- length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG (By similarity); Belongs to the WD repeat Groucho/TLE family."},{"id":"ENSMUSP00000026469","abundance":3.07,"rank":7055,"name":"Nab2","annotation":"NGFI-A-binding protein 2; Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability."},{"id":"ENSMUSP00000072945","abundance":3.07,"rank":7056,"name":"Myom1","annotation":"Myomesin-1; May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle. May also contact myosin filaments. Also binds beta-integrins."},{"id":"ENSMUSP00000098796","abundance":3.07,"rank":7057,"name":"Bst1","annotation":"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth."},{"id":"ENSMUSP00000031238","abundance":3.06,"rank":7058,"name":"Gbp9","annotation":"Guanylate-binding protein 9."},{"id":"ENSMUSP00000053901","abundance":3.06,"rank":7059,"name":"Sprn","annotation":"Shadow of prion protein; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP."},{"id":"ENSMUSP00000032683","abundance":3.06,"rank":7060,"name":"Lypd5","annotation":"Ly6/PLAUR domain-containing protein 5."},{"id":"ENSMUSP00000032585","abundance":3.06,"rank":7061,"name":"Pop4","annotation":"Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 1 family."},{"id":"ENSMUSP00000077760","abundance":3.06,"rank":7062,"name":"Ppp1r1b","annotation":"Protein phosphatase 1 regulatory subunit 1B; Inhibitor of protein-phosphatase 1."},{"id":"ENSMUSP00000077918","abundance":3.06,"rank":7063,"name":"Defb50","annotation":"Beta-defensin 50; Has bactericidal activity."},{"id":"ENSMUSP00000107587","abundance":3.06,"rank":7064,"name":"Arhgap22","annotation":"Rho GTPase-activating protein 22; Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1- dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter."},{"id":"ENSMUSP00000157311","abundance":3.06,"rank":7065,"name":"Cyp4f40","annotation":"Cytochrome P450, family 4, subfamily f, polypeptide 40; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000020169","abundance":3.06,"rank":7066,"name":"Enpp3","annotation":"Ectonucleotide pyrophosphatase/phosphodiesterase family member 3; Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic  [...] "},{"id":"ENSMUSP00000019808","abundance":3.06,"rank":7067,"name":"Plin5","annotation":"Perilipin-5; Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hyd [...] "},{"id":"ENSMUSP00000031984","abundance":3.05,"rank":7068,"name":"Smarcad1","annotation":"ATP-dependent helicase SMARCAD1; DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Promotes DNA end resection of double- strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and r [...] "},{"id":"ENSMUSP00000103687","abundance":3.05,"rank":7069,"name":"Fam219a","annotation":"Protein FAM219A; Belongs to the FAM219 family."},{"id":"ENSMUSP00000066633","abundance":3.05,"rank":7070,"name":"Ago3","annotation":"Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA- dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4. Possesses RNA slicer activity bu [...] "},{"id":"ENSMUSP00000110900","abundance":3.05,"rank":7071,"name":"Ccdc146","annotation":"Coiled-coil domain-containing 146."},{"id":"ENSMUSP00000119057","abundance":3.05,"rank":7072,"name":"Ehmt1","annotation":"Histone-lysine N-methyltransferase EHMT1; Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding [...] "},{"id":"ENSMUSP00000099916","abundance":3.05,"rank":7073,"name":"Ptges","annotation":"Prostaglandin E synthase; Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2)."},{"id":"ENSMUSP00000089498","abundance":3.05,"rank":7074,"name":"Hmgxb3","annotation":"HMG box domain-containing 3."},{"id":"ENSMUSP00000029629","abundance":3.05,"rank":7075,"name":"Pla2g12a","annotation":"Group XIIA secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine (By similarity)."},{"id":"ENSMUSP00000037890","abundance":3.05,"rank":7076,"name":"Sde2","annotation":"Replication stress response regulator SDE2; Involved in both DNA replication and cell cycle control. Unprocessed SDE2 interacts with PCNA via its PIP-box. The interaction with PCNA prevents monoubiquitination of the latter thereby inhibiting translesion DNA synthesis. The binding of SDE2 to PCNA also leads to processing of SDE2 by an unidentified deubiquitinating enzyme, cleaving off the N-terminal ubiquitin-like domain. The resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. Binding of SDE2 to PCNA is necessary to counteract dama [...] "},{"id":"ENSMUSP00000023089","abundance":3.05,"rank":7077,"name":"Wbp2nl","annotation":"Postacrosomal sheath WW domain-binding protein; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization."},{"id":"ENSMUSP00000027867","abundance":3.04,"rank":7078,"name":"Ccdc181","annotation":"Coiled-coil domain-containing protein 181; Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids."},{"id":"ENSMUSP00000105871","abundance":3.04,"rank":7079,"name":"Ints10","annotation":"Integrator complex subunit 10; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex."},{"id":"ENSMUSP00000055382","abundance":3.04,"rank":7080,"name":"Saysd1","annotation":"SAYSvFN domain-containing protein 1."},{"id":"ENSMUSP00000070413","abundance":3.04,"rank":7081,"name":"Dnaja4","annotation":"DnaJ homolog subfamily A member 4."},{"id":"ENSMUSP00000013220","abundance":3.04,"rank":7082,"name":"Amotl1","annotation":"Angiomotin-like protein 1; Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus."},{"id":"ENSMUSP00000040703","abundance":3.04,"rank":7083,"name":"Mgarp","annotation":"Protein MGARP; Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology."},{"id":"ENSMUSP00000098045","abundance":3.04,"rank":7084,"name":"Krtap4-6","annotation":"Keratin associated protein 4-6."},{"id":"ENSMUSP00000086796","abundance":3.04,"rank":7085,"name":"Pdxp","annotation":"Pyridoxal phosphate phosphatase; Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine (By similarity). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'- phosphate (PMP), with  [...] "},{"id":"ENSMUSP00000083747","abundance":3.04,"rank":7086,"name":"Slc41a1","annotation":"Solute carrier family 41 member 1; Acts as a magnesium transporter that is responsive to magnesium balance; Belongs to the SLC41A transporter family."},{"id":"ENSMUSP00000101271","abundance":3.04,"rank":7087,"name":"Ajap1","annotation":"Adherens junction-associated protein 1; Plays a role in cell adhesion and cell migration."},{"id":"ENSMUSP00000031632","abundance":3.04,"rank":7088,"name":"Zkscan14","annotation":"Zinc finger protein 394; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000051438","abundance":3.03,"rank":7089,"name":"Pisd","annotation":"Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily."},{"id":"ENSMUSP00000105243","abundance":3.03,"rank":7090,"name":"Chd9","annotation":"Chromodomain-helicase-DNA-binding protein 9; Acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. Proposed to be a ATP-dependent chromatin remodeling protein. Has DNA-dependent ATPase activity and binds to A/T- rich DNA (By similarity). Associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis; Belongs to the SNF2/RAD54 helicase family."},{"id":"ENSMUSP00000134457","abundance":3.03,"rank":7091,"name":"Dmbx1","annotation":"Diencephalon/mesencephalon homeobox protein 1; Functions as a transcriptional repressor. May repress OTX2- mediated transactivation by forming a heterodimer with OTX2 on the P3C (5'-TAATCCGATTA-3') sequence. Required for brain development, neonatal survival, postnatal growth, and nursing ability. Belongs to the paired homeobox family."},{"id":"ENSMUSP00000030917","abundance":3.03,"rank":7092,"name":"Ski","annotation":"Ski oncogene; May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling; Belongs to the SKI family."},{"id":"ENSMUSP00000028045","abundance":3.03,"rank":7093,"name":"Mrc1","annotation":"Macrophage mannose receptor 1; Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens."},{"id":"ENSMUSP00000112650","abundance":3.03,"rank":7094,"name":"Gm1993","annotation":"Predicted gene 1993."},{"id":"ENSMUSP00000099190","abundance":3.03,"rank":7095,"name":"Gm5935","annotation":"Predicted gene 5935."},{"id":"ENSMUSP00000034466","abundance":3.03,"rank":7096,"name":"Gnpat","annotation":"Dihydroxyacetone phosphate acyltransferase; Belongs to the GPAT/DAPAT family."},{"id":"ENSMUSP00000063912","abundance":3.02,"rank":7097,"name":"Lrrc56","annotation":"Leucine-rich repeat-containing protein 56; Required for the assembly of dynein arms."},{"id":"ENSMUSP00000028918","abundance":3.02,"rank":7098,"name":"Scp2d1","annotation":"SCP2 sterol-binding domain-containing protein 1."},{"id":"ENSMUSP00000031590","abundance":3.02,"rank":7099,"name":"Rbm19","annotation":"Probable RNA-binding protein 19; Plays a role in embryo pre-implantation development. Belongs to the RRM MRD1 family."},{"id":"ENSMUSP00000094062","abundance":3.02,"rank":7100,"name":"Gpr152","annotation":"Probable G-protein coupled receptor 152; Orphan receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000142138","abundance":3.02,"rank":7101,"name":"Gucy1a1","annotation":"Guanylate cyclase soluble subunit alpha-1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family."},{"id":"ENSMUSP00000029626","abundance":3.02,"rank":7102,"name":"Casp6","annotation":"Caspase-6 subunit p11; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity)."},{"id":"ENSMUSP00000036555","abundance":3.02,"rank":7103,"name":"Ipo4","annotation":"Importin-4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis rel [...] "},{"id":"ENSMUSP00000032843","abundance":3.02,"rank":7104,"name":"Tmem126b","annotation":"Complex I assembly factor TMEM126B, mitochondrial; Chaperone protein involved in the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Participates in constructing the membrane arm of complex I (By similarity)."},{"id":"ENSMUSP00000003319","abundance":3.02,"rank":7105,"name":"Abcf3","annotation":"ATP-binding cassette sub-family F member 3; Displays an antiviral effect against flaviviruses such as west Nile virus (WNV) in the presence of OAS1B."},{"id":"ENSMUSP00000019701","abundance":3.02,"rank":7106,"name":"Dusp9","annotation":"Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000033597","abundance":3.02,"rank":7107,"name":"Hmgn5","annotation":"High mobility group nucleosome-binding domain-containing protein 5; Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction."},{"id":"ENSMUSP00000031935","abundance":3.02,"rank":7108,"name":"1700074P13Rik","annotation":"RIKEN cDNA 1700074P13 gene; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000087896","abundance":3.01,"rank":7109,"name":"Utp3","annotation":"Something about silencing protein 10; Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain. Belongs to the SAS10 family."},{"id":"ENSMUSP00000020017","abundance":3.01,"rank":7110,"name":"Crybg1","annotation":"Crystallin beta-gamma domain-containing 1; Belongs to the beta/gamma-crystallin family."},{"id":"ENSMUSP00000010192","abundance":3.01,"rank":7111,"name":"Ifrd2","annotation":"Interferon-related developmental regulator 2."},{"id":"ENSMUSP00000022909","abundance":3.01,"rank":7112,"name":"Dcaf13","annotation":"DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity); Belongs to the WD repeat DCAF13/WDSOF1 family."},{"id":"ENSMUSP00000085986","abundance":3.01,"rank":7113,"name":"Arfgef1","annotation":"Brefeldin A-inhibited guanine nucleotide-exchange protein 1; Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and [...] "},{"id":"ENSMUSP00000062762","abundance":3.01,"rank":7114,"name":"Mterf2","annotation":"Transcription termination factor 2, mitochondrial; Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species."},{"id":"ENSMUSP00000032916","abundance":3.01,"rank":7115,"name":"Maz","annotation":"Myc-associated zinc finger protein; Transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide."},{"id":"ENSMUSP00000091624","abundance":3.01,"rank":7116,"name":"Tmem107","annotation":"Transmembrane protein 107; Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types. During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins."},{"id":"ENSMUSP00000027974","abundance":3.01,"rank":7117,"name":"Atf6","annotation":"Processed cyclic AMP-dependent transcription factor ATF-6 alpha; Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT- N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Bi [...] "},{"id":"ENSMUSP00000085423","abundance":3.01,"rank":7118,"name":"Zfx","annotation":"Zinc finger X-chromosomal protein; Probable transcriptional activator; Belongs to the krueppel C2H2-type zinc-finger protein family. ZFX/ZFY subfamily."},{"id":"ENSMUSP00000102590","abundance":3.01,"rank":7119,"name":"Kansl1","annotation":"KAT8 regulatory NSL complex subunit 1; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription."},{"id":"ENSMUSP00000097254","abundance":3.01,"rank":7120,"name":"Nrbf2","annotation":"Nuclear receptor-binding factor 2; May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity). Involved in the induction of starvation-induced autophagy. Modulates ATG14-linked lipid kinase activity of PIK3C3 and stabilzes PI3K complex I (PI3KC3-C1) assembly. May play a role in neural progenitor cell survival during differentiation."},{"id":"ENSMUSP00000104762","abundance":3.01,"rank":7121,"name":"Zfp879","annotation":"Zinc finger protein 879; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000035316","abundance":3.01,"rank":7122,"name":"Fancd2os","annotation":"FANCD2 opposite strand protein."},{"id":"ENSMUSP00000031388","abundance":3,"rank":7123,"name":"Vps33a","annotation":"Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] "},{"id":"ENSMUSP00000130535","abundance":3,"rank":7124,"name":"Suds3","annotation":"Sin3 histone deacetylase corepressor complex component SDS3; Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity)."},{"id":"ENSMUSP00000153358","abundance":3,"rank":7125,"name":"Il3ra","annotation":"Interleukin-3 receptor subunit alpha; In mouse, there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors."},{"id":"ENSMUSP00000026670","abundance":3,"rank":7126,"name":"Nptx1","annotation":"Neuronal pentraxin-1; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses."},{"id":"ENSMUSP00000094211","abundance":3,"rank":7127,"name":"Gm5169","annotation":"Predicted gene, 382277."},{"id":"ENSMUSP00000053120","abundance":3,"rank":7128,"name":"Rtel1","annotation":"Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by  [...] "},{"id":"ENSMUSP00000009732","abundance":3,"rank":7129,"name":"St6galnac1","annotation":"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; Transfers CMP-NeuAc with an alpha-2,6-linkage to the GalNAc residues of GalNAc-O-Ser/Thr, Gal-beta-1,3-GalNAc-O-Ser/Thr and NeuAc- alpha-2,3-Gal-beta-1,3-GalNAc-O-Ser/Thr are substrates. Higher activity towards GalNAc-O-Ser/Thr."},{"id":"ENSMUSP00000081104","abundance":3,"rank":7130,"name":"Cd209b","annotation":"CD209 antigen-like protein B; Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates."},{"id":"ENSMUSP00000097787","abundance":3,"rank":7131,"name":"Miga2","annotation":"Mitoguardin 2; Regulator of mitochondrial fusion. Acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD (By similarity)."},{"id":"ENSMUSP00000046643","abundance":3,"rank":7132,"name":"Utp6","annotation":"U3 small nucleolar RNA-associated protein 6 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the UTP6 family."},{"id":"ENSMUSP00000075613","abundance":3,"rank":7133,"name":"Zfp512","annotation":"Zinc finger protein 512; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000049770","abundance":2.99,"rank":7134,"name":"Mars2","annotation":"Methionine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000103929","abundance":2.99,"rank":7135,"name":"Foxn1","annotation":"Forkhead box protein N1; Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, includin [...] "},{"id":"ENSMUSP00000101012","abundance":2.99,"rank":7136,"name":"Arhgap45","annotation":"Rho GTPase-activating protein 45; Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR- domin which is able to play an autoinhibitory effect on this RhoGAP activity."},{"id":"ENSMUSP00000055413","abundance":2.99,"rank":7137,"name":"1700019D03Rik","annotation":"Small membrane A-kinase anchor protein; Binds to type I regulatory subunits of protein kinase A (PKA- RI) and may anchor/target them to the plasma membrane."},{"id":"ENSMUSP00000038150","abundance":2.99,"rank":7138,"name":"Itpr3","annotation":"Inositol 1,4,5-trisphosphate receptor type 3; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium."},{"id":"ENSMUSP00000020307","abundance":2.99,"rank":7139,"name":"Anapc16","annotation":"Anaphase-promoting complex subunit 16; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC16 family."},{"id":"ENSMUSP00000037447","abundance":2.99,"rank":7140,"name":"Ttyh3","annotation":"Protein tweety homolog 3; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction (By similarity)."},{"id":"ENSMUSP00000095251","abundance":2.98,"rank":7141,"name":"2700062C07Rik","annotation":"UPF0711 protein C18orf21 homolog; Belongs to the UPF0711 family."},{"id":"ENSMUSP00000108371","abundance":2.98,"rank":7142,"name":"Bcl2","annotation":"Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release."},{"id":"ENSMUSP00000035244","abundance":2.98,"rank":7143,"name":"Dhx29","annotation":"ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily."},{"id":"ENSMUSP00000041007","abundance":2.98,"rank":7144,"name":"Slc4a5","annotation":"Anion exchange protein."},{"id":"ENSMUSP00000058699","abundance":2.98,"rank":7145,"name":"Slc6a5","annotation":"Sodium- and chloride-dependent glycine transporter 2; Sodium- and chloride-dependent glycine transporter. Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (By similarity)."},{"id":"ENSMUSP00000056219","abundance":2.98,"rank":7146,"name":"Nudt6","annotation":"Nucleoside diphosphate-linked moiety X motif 6; May contribute to the regulation of cell proliferation. Belongs to the Nudix hydrolase family."},{"id":"ENSMUSP00000045539","abundance":2.98,"rank":7147,"name":"Fam53a","annotation":"Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle. Belongs to the FAM53 family."},{"id":"ENSMUSP00000001975","abundance":2.98,"rank":7148,"name":"Nacc1","annotation":"Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Involved in the acute behavioral and neurological responses to cocaine and amphetamines."},{"id":"ENSMUSP00000070727","abundance":2.98,"rank":7149,"name":"Zdhhc19","annotation":"Palmitoyltransferase ZDHHC19; Palmitoyltransferase that mediates palmitoylation of STAT3 and RRAS. Palmitoylation of STAT3 induces the homodimerization and transcriptional activation of STAT3, thereby, promoting inflammation and cancer. Palmitoylation of RRAS is linked to cell viability. May be involved in S-stearoylation of STAT3."},{"id":"ENSMUSP00000028209","abundance":2.97,"rank":7150,"name":"Dolpp1","annotation":"Dolichyldiphosphatase 1; Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate."},{"id":"ENSMUSP00000059499","abundance":2.97,"rank":7151,"name":"Spin2c","annotation":"Spindlin-2C; May be involved in the regulation of cell cycle progression. Exhibits H3K4me3-binding activity."},{"id":"ENSMUSP00000113737","abundance":2.97,"rank":7152,"name":"Dmrtc1c1","annotation":"DMRT-like family C1c1."},{"id":"ENSMUSP00000113033","abundance":2.97,"rank":7153,"name":"Dmrtc1c2","annotation":"DMRT-like family C1c1."},{"id":"ENSMUSP00000086568","abundance":2.97,"rank":7154,"name":"Gm5168","annotation":"Predicted gene, EG382275."},{"id":"ENSMUSP00000043537","abundance":2.97,"rank":7155,"name":"Sft2d2","annotation":"Vesicle transport protein SFT2B; May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex. Belongs to the SFT2 family."},{"id":"ENSMUSP00000018315","abundance":2.97,"rank":7156,"name":"Vmp1","annotation":"Vacuole membrane protein 1; Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death (By similarity). May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Required for autophagosome formation (By similarity); Belongs to the VMP1 family."},{"id":"ENSMUSP00000047475","abundance":2.97,"rank":7157,"name":"Trafd1","annotation":"TRAF-type zinc finger domain-containing protein 1; Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3."},{"id":"ENSMUSP00000132435","abundance":2.97,"rank":7158,"name":"Gbp2","annotation":"Guanylate-binding protein 2; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (By similarity). Exhibits antiviral activity against influenza virus. Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity); Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily."},{"id":"ENSMUSP00000147592","abundance":2.97,"rank":7159,"name":"Olfr601","annotation":"Olfactory receptor 601."},{"id":"ENSMUSP00000114381","abundance":2.96,"rank":7160,"name":"Ccdc42","annotation":"Coiled-coil domain-containing protein 42; Required for sperm development. Belongs to the CFAP73 family."},{"id":"ENSMUSP00000072929","abundance":2.96,"rank":7161,"name":"Erlec1","annotation":"Endoplasmic reticulum lectin 1; Probable lectin that binds selectively to improperly folded lumenal proteins. May function in endoplasmic reticulum quality control and endoplasmic reticulum-associated degradation (ERAD) of both non- glycosylated proteins and glycoproteins (By similarity)."},{"id":"ENSMUSP00000063398","abundance":2.96,"rank":7162,"name":"Mtif3","annotation":"Translation initiation factor IF-3, mitochondrial; IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins."},{"id":"ENSMUSP00000057844","abundance":2.96,"rank":7163,"name":"Blnk","annotation":"B-cell linker protein; Functions as a central linker protein, downstream of the B- cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR- mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-medi [...] "},{"id":"ENSMUSP00000038483","abundance":2.96,"rank":7164,"name":"Ptger2","annotation":"Prostaglandin E2 receptor EP2 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000141300","abundance":2.96,"rank":7165,"name":"Pabpc4l","annotation":"Poly(A)-binding protein, cytoplasmic 4-like."},{"id":"ENSMUSP00000029435","abundance":2.95,"rank":7166,"name":"Dclre1b","annotation":"5' exonuclease Apollo; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres  [...] "},{"id":"ENSMUSP00000144615","abundance":2.95,"rank":7167,"name":"Tmem214","annotation":"Transmembrane protein 214; Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress (By similarity); Belongs to the TMEM214 family."},{"id":"ENSMUSP00000029087","abundance":2.95,"rank":7168,"name":"Ogfr","annotation":"Opioid growth factor receptor; Receptor for opioid growth factor (OGF), also known as Met- enkephalin. Seems to be involved in growth regulation (By similarity)."},{"id":"ENSMUSP00000015000","abundance":2.95,"rank":7169,"name":"Tmem208","annotation":"Transmembrane protein 208; May function as a negative regulator of endoplasmic reticulum-stress induced autophagy."},{"id":"ENSMUSP00000022580","abundance":2.95,"rank":7170,"name":"Slc25a30","annotation":"Kidney mitochondrial carrier protein 1; Probable transporter."},{"id":"ENSMUSP00000042229","abundance":2.95,"rank":7171,"name":"Myo5c","annotation":"Myosin VC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000119790","abundance":2.95,"rank":7172,"name":"Heg1","annotation":"Protein HEG homolog 1; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May be acting by stabilizing endothelial cell junctions."},{"id":"ENSMUSP00000029575","abundance":2.95,"rank":7173,"name":"Extl2","annotation":"Exostosin-like 2; Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains."},{"id":"ENSMUSP00000082302","abundance":2.95,"rank":7174,"name":"Slc25a36","annotation":"Solute carrier family 25 member 36; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, Mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potentia [...] "},{"id":"ENSMUSP00000025885","abundance":2.95,"rank":7175,"name":"Znrd2","annotation":"Protein ZNRD2; Might play a role in mitosis. Could be a centromere- associated protein. Antigenic molecule. May induce anti-centromere antibodies."},{"id":"ENSMUSP00000136950","abundance":2.94,"rank":7176,"name":"Epn2","annotation":"Epsin-2; Plays a role in the formation of clathrin-coated invaginations and endocytosis."},{"id":"ENSMUSP00000020830","abundance":2.94,"rank":7177,"name":"Mfap3","annotation":"Microfibril-associated glycoprotein 3; Component of the elastin-associated microfibrils."},{"id":"ENSMUSP00000031391","abundance":2.94,"rank":7178,"name":"Bcl7a","annotation":"B-cell CLL/lymphoma 7 protein family member A; Belongs to the BCL7 family."},{"id":"ENSMUSP00000125434","abundance":2.94,"rank":7179,"name":"Exoc5","annotation":"Exocyst complex component 5; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane."},{"id":"ENSMUSP00000127325","abundance":2.93,"rank":7180,"name":"Gpat4","annotation":"Glycerol-3-phosphate acyltransferase 4; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Active against both saturated and unsaturated long-chain fatty acyl- CoAs (By similarity)."},{"id":"ENSMUSP00000034913","abundance":2.93,"rank":7181,"name":"Mcrip1","annotation":"Mapk-regulated corepressor-interacting protein 1; The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition."},{"id":"ENSMUSP00000021390","abundance":2.93,"rank":7182,"name":"Galc","annotation":"Galactocerebrosidase; Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon."},{"id":"ENSMUSP00000087714","abundance":2.93,"rank":7183,"name":"Trio","annotation":"Triple functional domain protein; Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth (By similarity). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA- selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis."},{"id":"ENSMUSP00000120016","abundance":2.93,"rank":7184,"name":"Dcaf17","annotation":"DDB1- and CUL4-associated factor 17; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex."},{"id":"ENSMUSP00000076217","abundance":2.93,"rank":7185,"name":"Gpn1","annotation":"GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding proteins, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. May be involved in nuclear localization of XPA."},{"id":"ENSMUSP00000001184","abundance":2.92,"rank":7186,"name":"Mxd1","annotation":"Max dimerization protein 1; Transcriptional repressor. MAD binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MAD thus antagonizes MYC transcriptional activity by competing for MAX."},{"id":"ENSMUSP00000109482","abundance":2.92,"rank":7187,"name":"Nagk","annotation":"N-acetyl-D-glucosamine kinase; Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity."},{"id":"ENSMUSP00000006587","abundance":2.92,"rank":7188,"name":"Tmem189","annotation":"Plasmanylethanolamine desaturase; Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms; Belongs to the fatty acid desaturase CarF family."},{"id":"ENSMUSP00000017961","abundance":2.92,"rank":7189,"name":"Jph2","annotation":"Junctophilin-2 N-terminal fragment; [Junctophilin-2]: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes. Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads. Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in rya [...] "},{"id":"ENSMUSP00000143251","abundance":2.92,"rank":7190,"name":"Stap1","annotation":"Signal-transducing adaptor protein 1; May function as an adapter molecule downstream of KIT in the proliferation or differentiation of hematopoietic stem cells."},{"id":"ENSMUSP00000033591","abundance":2.92,"rank":7191,"name":"Itm2a","annotation":"Integral membrane protein 2A; Belongs to the ITM2 family."},{"id":"ENSMUSP00000021932","abundance":2.92,"rank":7192,"name":"Drd1","annotation":"D(1A) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase."},{"id":"ENSMUSP00000070847","abundance":2.92,"rank":7193,"name":"Cd248","annotation":"Endosialin; May play a role in angiogenesis or vascular function."},{"id":"ENSMUSP00000024119","abundance":2.92,"rank":7194,"name":"Trip6","annotation":"Thyroid receptor-interacting protein 6; Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF- kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity); Belongs to the zyxin/ajuba family."},{"id":"ENSMUSP00000051805","abundance":2.91,"rank":7195,"name":"Gprin3","annotation":"G protein-regulated inducer of neurite outgrowth 3; May be involved in neurite outgrowth."},{"id":"ENSMUSP00000103495","abundance":2.91,"rank":7196,"name":"Car10","annotation":"Carbonic anhydrase-related protein 10; Does not have a catalytic activity."},{"id":"ENSMUSP00000068940","abundance":2.91,"rank":7197,"name":"Abcd2","annotation":"ATP-binding cassette sub-family D member 2; Probable transporter."},{"id":"ENSMUSP00000099589","abundance":2.91,"rank":7198,"name":"Sema3b","annotation":"Semaphorin-3B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons."},{"id":"ENSMUSP00000034260","abundance":2.91,"rank":7199,"name":"B3gnt3","annotation":"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides. Also acts as a core1-1,3-N- acetylglucosaminyltransferase (Core1-beta3GlcNAcT) to form the 6-sulfo sialyl Lewis x on extended core1 O-glycans. Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000050788","abundance":2.91,"rank":7200,"name":"Phkb","annotation":"Phosphorylase b kinase regulatory subunit beta; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity)."},{"id":"ENSMUSP00000100745","abundance":2.91,"rank":7201,"name":"Tex13c1","annotation":"Testis-expressed protein 13C-1; Belongs to the TEX13 family."},{"id":"ENSMUSP00000004715","abundance":2.91,"rank":7202,"name":"Mospd2","annotation":"Motile sperm domain-containing protein 2; Promotes migration of primary monocytes and neutrophils, in response to various chemokines."},{"id":"ENSMUSP00000091429","abundance":2.9,"rank":7203,"name":"Rnf213","annotation":"E3 ubiquitin-protein ligase RNF213; E3 ubiquitin-protein ligase involved in angiogenesis. Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression. Also has ATPase activity."},{"id":"ENSMUSP00000130551","abundance":2.9,"rank":7204,"name":"Hspb9","annotation":"Heat shock protein beta-9."},{"id":"ENSMUSP00000040229","abundance":2.9,"rank":7205,"name":"Dtx4","annotation":"E3 ubiquitin-protein ligase DTX4; Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations."},{"id":"ENSMUSP00000076576","abundance":2.9,"rank":7206,"name":"Klk1b4","annotation":"Kallikrein 1-related peptidase-like b4."},{"id":"ENSMUSP00000089097","abundance":2.9,"rank":7207,"name":"Srd5a1","annotation":"3-oxo-5-alpha-steroid 4-dehydrogenase 1; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology (By similarity)."},{"id":"ENSMUSP00000044722","abundance":2.9,"rank":7208,"name":"Cyp2c38","annotation":"Cytochrome P450 2C38; Metabolizes arachidonic acid to produce 11,12- epoxyeicosatrienoic acid (EET); Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000041790","abundance":2.9,"rank":7209,"name":"Pcgf3","annotation":"Polycomb group RING finger protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF5 as part of a PRC1-like complex th [...] "},{"id":"ENSMUSP00000023329","abundance":2.9,"rank":7210,"name":"Retnla","annotation":"Resistin-like alpha; Probable hormone. Plays a role in pulmonary vascular remodeling; Belongs to the resistin/FIZZ family."},{"id":"ENSMUSP00000151826","abundance":2.89,"rank":7211,"name":"Gm9045","annotation":"Predicted gene 9045."},{"id":"ENSMUSP00000151669","abundance":2.89,"rank":7212,"name":"Gm9048","annotation":"Predicted gene 9048."},{"id":"ENSMUSP00000151392","abundance":2.89,"rank":7213,"name":"Gm9049","annotation":"Predicted gene 9045."},{"id":"ENSMUSP00000097093","abundance":2.89,"rank":7214,"name":"Btaf1","annotation":"B-TFIID TATA-box-binding protein-associated factor 1."},{"id":"ENSMUSP00000078945","abundance":2.89,"rank":7215,"name":"Htt","annotation":"Huntingtin, myristoylated N-terminal fragment; [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function."},{"id":"ENSMUSP00000101909","abundance":2.89,"rank":7216,"name":"Cyth1","annotation":"Cytohesin-1; Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity."},{"id":"ENSMUSP00000053341","abundance":2.89,"rank":7217,"name":"Lysmd4","annotation":"LysM and putative peptidoglycan-binding domain-containing protein 4."},{"id":"ENSMUSP00000030556","abundance":2.89,"rank":7218,"name":"Ptpn12","annotation":"Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (By similarity)."},{"id":"ENSMUSP00000075011","abundance":2.88,"rank":7219,"name":"Abcb10","annotation":"ATP-binding cassette sub-family B member 10, mitochondrial; May mediate critical mitochondrial transport functions related to heme biosynthesis; Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily."},{"id":"ENSMUSP00000120659","abundance":2.88,"rank":7220,"name":"Prkrip1","annotation":"PRKR-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity."},{"id":"ENSMUSP00000111097","abundance":2.88,"rank":7221,"name":"Thpo","annotation":"Thrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets; Belongs to the EPO/TPO family."},{"id":"ENSMUSP00000102805","abundance":2.88,"rank":7222,"name":"Mindy1","annotation":"Ubiquitin carboxyl-terminal hydrolase MINDY-1; Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover."},{"id":"ENSMUSP00000089079","abundance":2.88,"rank":7223,"name":"Frmd4a","annotation":"FERM domain-containing protein 4A; Scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4B in epithelial polarization. May regulate MAPT secretion by activating ARF6- signaling (By similarity)."},{"id":"ENSMUSP00000064840","abundance":2.88,"rank":7224,"name":"Cnot10","annotation":"CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity). Belongs to the CNOT10 family."},{"id":"ENSMUSP00000111326","abundance":2.88,"rank":7225,"name":"Pcdha2","annotation":"Protocadherin alpha 2."},{"id":"ENSMUSP00000032808","abundance":2.88,"rank":7226,"name":"2200002D01Rik","annotation":"RIKEN cDNA 2200002D01 gene."},{"id":"ENSMUSP00000075242","abundance":2.88,"rank":7227,"name":"Arhgap35","annotation":"Rho GTPase-activating protein 35; Rho GTPase-activating protein (GAP). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity. This binding is inhibited by phosphorylation by PRKCA (By similarity). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis. Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). Transduces [...] "},{"id":"ENSMUSP00000045201","abundance":2.88,"rank":7228,"name":"Wipi2","annotation":"WD repeat domain phosphoinositide-interacting protein 2; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 [...] "},{"id":"ENSMUSP00000019967","abundance":2.88,"rank":7229,"name":"Mical1","annotation":"[F-actin]-monooxygenase MICAL1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involv [...] "},{"id":"ENSMUSP00000031246","abundance":2.88,"rank":7230,"name":"Ibsp","annotation":"Bone sialoprotein 2; Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment (By similarity)."},{"id":"ENSMUSP00000044416","abundance":2.88,"rank":7231,"name":"Cpne9","annotation":"Copine-9; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Plays a role in dendrite formation by melanocytes."},{"id":"ENSMUSP00000027315","abundance":2.88,"rank":7232,"name":"Zfp142","annotation":"Zinc finger protein 142; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000148181","abundance":2.88,"rank":7233,"name":"Olfr570","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000132516","abundance":2.88,"rank":7234,"name":"Dus1l","annotation":"tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs; Belongs to the Dus family. Dus1 subfamily."},{"id":"ENSMUSP00000021772","abundance":2.87,"rank":7235,"name":"Mrs2","annotation":"Magnesium transporter MRS2 homolog, mitochondrial; Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix. Required for normal expression of the mitochondrial respiratory complex I subunits."},{"id":"ENSMUSP00000094874","abundance":2.87,"rank":7236,"name":"Prkce","annotation":"Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] "},{"id":"ENSMUSP00000100618","abundance":2.87,"rank":7237,"name":"H2al2a","annotation":"Histone H2A-Bbd type 1; Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells. Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes. In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition pro [...] "},{"id":"ENSMUSP00000065284","abundance":2.87,"rank":7238,"name":"Ocln","annotation":"Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the ELL/occludin family."},{"id":"ENSMUSP00000132498","abundance":2.87,"rank":7239,"name":"Tex10","annotation":"Testis-expressed protein 10; Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity)."},{"id":"ENSMUSP00000106845","abundance":2.87,"rank":7240,"name":"Ifi204","annotation":"Interferon-activable protein 204; Inhibits the transcription of ribosomal RNA. May inhibit DNA binding by UBTF. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways. Acts as a coactivator of RUNX2 during osteogenesis. May be involved in macrophage differentiation. Enables skeletal muscle and cardiac myocyte differentiation by sequestring Id proteins in the cytosol and promoting their ubiquitination and subsequent degradation. Belongs to the HIN-200 family."},{"id":"ENSMUSP00000043103","abundance":2.87,"rank":7241,"name":"R3hdm1","annotation":"R3H domain-containing 1."},{"id":"ENSMUSP00000111624","abundance":2.87,"rank":7242,"name":"Tmlhe","annotation":"Trimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML); Belongs to the gamma-BBH/TMLD family."},{"id":"ENSMUSP00000017354","abundance":2.87,"rank":7243,"name":"Med24","annotation":"Mediator of RNA polymerase II transcription subunit 24; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] "},{"id":"ENSMUSP00000029447","abundance":2.87,"rank":7244,"name":"Sike1","annotation":"Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity)."},{"id":"ENSMUSP00000025706","abundance":2.87,"rank":7245,"name":"Tnfrsf25","annotation":"Tumor necrosis factor receptor superfamily, member 25."},{"id":"ENSMUSP00000094396","abundance":2.87,"rank":7246,"name":"Rnf121","annotation":"RING finger protein 121; Belongs to the RNF121 family."},{"id":"ENSMUSP00000022538","abundance":2.86,"rank":7247,"name":"Mrpl57","annotation":"Ribosomal protein 63, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL63 family."},{"id":"ENSMUSP00000131138","abundance":2.86,"rank":7248,"name":"C2cd4b","annotation":"Family with sequence similarity 148, member B."},{"id":"ENSMUSP00000040797","abundance":2.86,"rank":7249,"name":"Npy6r","annotation":"Neuropeptide Y receptor type 6; Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY = PYY >= NPY (2-36) = [Leu-31, Pro-34] NPY > NPY (13-36) > PP. The activity of this receptor is mediated by G proteins that inhibits adenylate cyclase activity."},{"id":"ENSMUSP00000027367","abundance":2.86,"rank":7250,"name":"Ctdsp1","annotation":"Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells."},{"id":"ENSMUSP00000090227","abundance":2.86,"rank":7251,"name":"Slc16a10","annotation":"Monocarboxylate transporter 10; Sodium-independent transporter that mediates the uptake of aromatic acids. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells."},{"id":"ENSMUSP00000041049","abundance":2.86,"rank":7252,"name":"Wdr18","annotation":"WD repeat-containing protein 18; May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes; Belongs to the WD repeat IPI3/WDR18 family."},{"id":"ENSMUSP00000050750","abundance":2.86,"rank":7253,"name":"Peg3","annotation":"Paternally-expressed gene 3 protein; Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Plays a role in regulating maternal behavior and offspring growth. Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000133431","abundance":2.86,"rank":7254,"name":"Dyrk1b","annotation":"Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activity. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily."},{"id":"ENSMUSP00000039529","abundance":2.86,"rank":7255,"name":"Tmem109","annotation":"Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death. Can form voltage-gated calcium and potassium channels in vitro (By similarity)."},{"id":"ENSMUSP00000102340","abundance":2.86,"rank":7256,"name":"Scube2","annotation":"Signal peptide, CUB and EGF-like domain-containing protein 2; Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to cause an increase in SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis."},{"id":"ENSMUSP00000053446","abundance":2.85,"rank":7257,"name":"Prl2c1","annotation":"Prolactin family 2, subfamily c, member 1."},{"id":"ENSMUSP00000111639","abundance":2.85,"rank":7258,"name":"Esrp2","annotation":"Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity)."},{"id":"ENSMUSP00000108583","abundance":2.85,"rank":7259,"name":"Prdm8","annotation":"PR domain zinc finger protein 8; Probable histone methyltransferase, preferentially acting on 'Lys-9' of histone H3. Histone methyltransferase activity has not been confirmed in other species. Involved in the control of steroidogenesis through transcriptional repression of steroidogenesis marker genes such as CYP17A1 and LHCGR. Forms with BHLHE22 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation. In the retina, it is required for rod bipolar and type 2 OFF-cone bipolar cell survival."},{"id":"ENSMUSP00000081578","abundance":2.85,"rank":7260,"name":"Slc31a2","annotation":"Probable low affinity copper uptake protein 2; Involved in low-affinity copper uptake; Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily."},{"id":"ENSMUSP00000043614","abundance":2.85,"rank":7261,"name":"Kin","annotation":"DNA/RNA-binding protein KIN17; Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo. Binds via its C- terminal domain to RNA in vitro."},{"id":"ENSMUSP00000061561","abundance":2.85,"rank":7262,"name":"Olfr685","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000000348","abundance":2.85,"rank":7263,"name":"Rtca","annotation":"RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing (By similarity); Belongs to the RNA 3'-terminal cyclase family. [...] "},{"id":"ENSMUSP00000022543","abundance":2.85,"rank":7264,"name":"Micu2","annotation":"Calcium uptake protein 2, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide- linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering."},{"id":"ENSMUSP00000051515","abundance":2.84,"rank":7265,"name":"Alkbh6","annotation":"Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6; Probable dioxygenase that requires molecular oxygen, alpha- ketoglutarate and iron; Belongs to the alkB family."},{"id":"ENSMUSP00000023502","abundance":2.84,"rank":7266,"name":"Snx4","annotation":"Sorting nexin-4; Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Belongs to the sorting nexin family."},{"id":"ENSMUSP00000035007","abundance":2.84,"rank":7267,"name":"Cmtm6","annotation":"CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...] "},{"id":"ENSMUSP00000020182","abundance":2.84,"rank":7268,"name":"Pex7","annotation":"Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import."},{"id":"ENSMUSP00000033652","abundance":2.84,"rank":7269,"name":"Phka2","annotation":"Phosphorylase b kinase regulatory subunit alpha, liver isoform; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin."},{"id":"ENSMUSP00000146187","abundance":2.84,"rank":7270,"name":"Phldb3","annotation":"Pleckstrin homology-like domain, family B, member 3."},{"id":"ENSMUSP00000063511","abundance":2.84,"rank":7271,"name":"Car8","annotation":"Carbonic anhydrase-related protein; Does not have a carbonic anhydrase catalytic activity; Belongs to the alpha-carbonic anhydrase family."},{"id":"ENSMUSP00000102157","abundance":2.84,"rank":7272,"name":"Iqck","annotation":"IQ motif-containing K."},{"id":"ENSMUSP00000098289","abundance":2.84,"rank":7273,"name":"1700024G13Rik","annotation":"UPF0728 protein C10orf53 homolog; Belongs to the UPF0728 family."},{"id":"ENSMUSP00000097433","abundance":2.83,"rank":7274,"name":"Olfr1141","annotation":"Olfactory receptor MOR177-10; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000086894","abundance":2.83,"rank":7275,"name":"Apol7b","annotation":"Apolipoprotein L 7b."},{"id":"ENSMUSP00000001631","abundance":2.83,"rank":7276,"name":"Acap1","annotation":"Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity)."},{"id":"ENSMUSP00000149070","abundance":2.83,"rank":7277,"name":"Olfr644","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000098686","abundance":2.83,"rank":7278,"name":"Lrig1","annotation":"Leucine-rich repeats and immunoglobulin-like domains protein 1; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation."},{"id":"ENSMUSP00000089781","abundance":2.83,"rank":7279,"name":"Msrb3","annotation":"Methionine-R-sulfoxide reductase B3, mitochondrial; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine."},{"id":"ENSMUSP00000115353","abundance":2.83,"rank":7280,"name":"Trp53rkb","annotation":"EKC/KEOPS complex subunit Tp53rk; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may t [...] "},{"id":"ENSMUSP00000031740","abundance":2.83,"rank":7281,"name":"Mepce","annotation":"7SK snRNA methylphosphate capping enzyme; S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA, leading to stabilize it."},{"id":"ENSMUSP00000137517","abundance":2.83,"rank":7282,"name":"Pcgf2","annotation":"Polycomb group RING finger protein 2; Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development (Probable). Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero- posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain [...] "},{"id":"ENSMUSP00000109500","abundance":2.83,"rank":7283,"name":"Tsc1","annotation":"Hamartin; In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Acts as a co-chaperone for HSP90AA1 facilitating HSP90AA1 chaperoning of protein clients such as kinases, TSC2 and glucocorticoid receptor NR3C1. Increases ATP binding to HSP90AA1 and inhibits HSP90AA1 ATPase activity. Competes with the activating co-chaperone AH [...] "},{"id":"ENSMUSP00000014640","abundance":2.83,"rank":7284,"name":"Ankrd28","annotation":"Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation (By similarity)."},{"id":"ENSMUSP00000005503","abundance":2.83,"rank":7285,"name":"Msh6","annotation":"DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, a [...] "},{"id":"ENSMUSP00000099398","abundance":2.83,"rank":7286,"name":"Cntnap1","annotation":"Contactin-associated protein 1; Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells."},{"id":"ENSMUSP00000145161","abundance":2.83,"rank":7287,"name":"Reg1","annotation":"Lithostathine-1; Might act as an inhibitor of spontaneous calcium carbonate precipitation."},{"id":"ENSMUSP00000139301","abundance":2.83,"rank":7288,"name":"Gm11983","annotation":"Predicted gene 11983."},{"id":"ENSMUSP00000094986","abundance":2.83,"rank":7289,"name":"Tsc2","annotation":"Tuberin; In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (By similarity). May also play a role in microtubule-mediated protein transport. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity)."},{"id":"ENSMUSP00000081312","abundance":2.83,"rank":7290,"name":"Ago4","annotation":"Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs; Belongs to the argonaute family. Ago subfamily."},{"id":"ENSMUSP00000023814","abundance":2.82,"rank":7291,"name":"Npff","annotation":"Pro-FMRFamide-related neuropeptide FF; Morphine modulating peptides. Have wide-ranging physiologic effects, including the modulation of morphine-induced analgesia, elevation of arterial blood pressure, and increased somatostatin secretion from the pancreas. Neuropeptide FF potentiates and sensitizes ASIC1 and ASIC3 channels; Belongs to the FARP (FMRFamide related peptide) family."},{"id":"ENSMUSP00000029451","abundance":2.82,"rank":7292,"name":"Tspan2","annotation":"Tetraspanin-2; May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath; Belongs to the tetraspanin (TM4SF) family."},{"id":"ENSMUSP00000118546","abundance":2.82,"rank":7293,"name":"Ldb1","annotation":"LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state."},{"id":"ENSMUSP00000034339","abundance":2.82,"rank":7294,"name":"Cdh5","annotation":"Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endothelial cell polarit [...] "},{"id":"ENSMUSP00000059927","abundance":2.82,"rank":7295,"name":"Stambpl1","annotation":"AMSH-like protease; Zinc metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not cleave 'Lys-48'-linked polyubiquitin chains (By similarity)."},{"id":"ENSMUSP00000010189","abundance":2.82,"rank":7296,"name":"Tmem115","annotation":"Transmembrane protein 115; May play a role in retrograde transport of proteins from the Golgi to the endoplasmic reticulum. May indirectly play a role in protein glycosylation in the Golgi."},{"id":"ENSMUSP00000062103","abundance":2.82,"rank":7297,"name":"Il17re","annotation":"Interleukin-17 receptor E; Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors."},{"id":"ENSMUSP00000078134","abundance":2.82,"rank":7298,"name":"Chia1","annotation":"Acidic mammalian chitinase; Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on [...] "},{"id":"ENSMUSP00000059630","abundance":2.82,"rank":7299,"name":"Prm3","annotation":"Protamine-3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex."},{"id":"ENSMUSP00000042844","abundance":2.82,"rank":7300,"name":"Parm1","annotation":"Prostate androgen-regulated mucin-like protein 1 homolog; May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis."},{"id":"ENSMUSP00000136137","abundance":2.82,"rank":7301,"name":"Gm10096","annotation":"Predicted gene 10096."},{"id":"ENSMUSP00000099170","abundance":2.82,"rank":7302,"name":"Gm10486","annotation":"Predicted gene 10486."},{"id":"ENSMUSP00000099177","abundance":2.82,"rank":7303,"name":"Gm14632","annotation":"Predicted gene 14632."},{"id":"ENSMUSP00000078727","abundance":2.82,"rank":7304,"name":"Gm10058","annotation":"Predicted gene 10058."},{"id":"ENSMUSP00000074848","abundance":2.82,"rank":7305,"name":"Gm10147","annotation":"Predicted gene, ENSMUSG00000073257."},{"id":"ENSMUSP00000113334","abundance":2.82,"rank":7306,"name":"Gm14525","annotation":"Predicted gene 14525."},{"id":"ENSMUSP00000112771","abundance":2.82,"rank":7307,"name":"Gm6121","annotation":"Predicted gene 6121."},{"id":"ENSMUSP00000099180","abundance":2.82,"rank":7308,"name":"Gm10488","annotation":"Predicted gene, ENSMUSG00000073257."},{"id":"ENSMUSP00000099168","abundance":2.82,"rank":7309,"name":"Gm14819","annotation":"Predicted gene 14819."},{"id":"ENSMUSP00000114126","abundance":2.82,"rank":7310,"name":"Gm10230","annotation":"Predicted gene 10230."},{"id":"ENSMUSP00000137394","abundance":2.82,"rank":7311,"name":"Gm4836","annotation":"Predicted gene 4836."},{"id":"ENSMUSP00000136976","abundance":2.82,"rank":7312,"name":"Gm10487","annotation":"Predicted gene 10487."},{"id":"ENSMUSP00000097152","abundance":2.82,"rank":7313,"name":"Fam122a","annotation":"Protein FAM122A; Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity. Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA); Belongs to the FAM122 family."},{"id":"ENSMUSP00000026663","abundance":2.82,"rank":7314,"name":"Cbx8","annotation":"Chromobox protein homolog 8; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity)."},{"id":"ENSMUSP00000018651","abundance":2.82,"rank":7315,"name":"Trpv2","annotation":"Transient receptor potential cation channel subfamily V member 2; Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF- I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily."},{"id":"ENSMUSP00000132645","abundance":2.82,"rank":7316,"name":"Gm6169","annotation":"Predicted gene 6169."},{"id":"ENSMUSP00000033486","abundance":2.82,"rank":7317,"name":"Plp2","annotation":"Proteolipid protein 2; May play a role in cell differentiation in the intestinal epithelium."},{"id":"ENSMUSP00000110011","abundance":2.82,"rank":7318,"name":"Cmss1","annotation":"Protein CMSS1; Belongs to the CMS1 family."},{"id":"ENSMUSP00000113228","abundance":2.82,"rank":7319,"name":"Lias","annotation":"Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family."},{"id":"ENSMUSP00000006565","abundance":2.82,"rank":7320,"name":"Cdc20","annotation":"Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation."},{"id":"ENSMUSP00000111393","abundance":2.82,"rank":7321,"name":"Tmem173","annotation":"Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] "},{"id":"ENSMUSP00000041157","abundance":2.82,"rank":7322,"name":"Spon1","annotation":"Spondin-1; Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity)."},{"id":"ENSMUSP00000049678","abundance":2.81,"rank":7323,"name":"Ucn3","annotation":"Urocortin-3; Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family."},{"id":"ENSMUSP00000003561","abundance":2.81,"rank":7324,"name":"Phyhip","annotation":"Phytanoyl-CoA hydroxylase-interacting protein; Its interaction with PHYH suggests a role in the development of the central system."},{"id":"ENSMUSP00000028663","abundance":2.81,"rank":7325,"name":"Creb3l1","annotation":"Processed cyclic AMP-responsive element-binding protein 3-like protein 1; Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain  [...] "},{"id":"ENSMUSP00000045141","abundance":2.81,"rank":7326,"name":"Trp53rka","annotation":"Transformation-related protein 53-regulating kinase A."},{"id":"ENSMUSP00000108678","abundance":2.81,"rank":7327,"name":"Shroom3","annotation":"Protein Shroom3; Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). Belongs to the shroom family."},{"id":"ENSMUSP00000049284","abundance":2.81,"rank":7328,"name":"Ints14","annotation":"Integrator complex subunit 14; Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing."},{"id":"ENSMUSP00000070629","abundance":2.81,"rank":7329,"name":"Defb42","annotation":"Beta-defensin 42; Has bactericidal activity (By similarity). May play a role in the antimicrobial protection of sperm and urogenital tract epithelia ; Belongs to the beta-defensin family."},{"id":"ENSMUSP00000046486","abundance":2.81,"rank":7330,"name":"Arhgef3","annotation":"Rho guanine nucleotide exchange factor 3; Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases."},{"id":"ENSMUSP00000022971","abundance":2.81,"rank":7331,"name":"Myc","annotation":"Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release."},{"id":"ENSMUSP00000055104","abundance":2.81,"rank":7332,"name":"Ticam1","annotation":"TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF- kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif [...] "},{"id":"ENSMUSP00000029172","abundance":2.81,"rank":7333,"name":"Ghrh","annotation":"Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone; Belongs to the glucagon family."},{"id":"ENSMUSP00000031477","abundance":2.81,"rank":7334,"name":"Golga3","annotation":"Golgin subfamily A member 3; Plays an important role in spermatogenesis and/or testis development. Probably identical with the serologically detectable male antigen (SDM). Probably involved in maintaining Golgi structure."},{"id":"ENSMUSP00000025292","abundance":2.81,"rank":7335,"name":"Dhx16","annotation":"DEAH (Asp-Glu-Ala-His) box polypeptide 16."},{"id":"ENSMUSP00000029566","abundance":2.8,"rank":7336,"name":"Efna1","annotation":"Ephrin-A1, secreted form; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial c [...] "},{"id":"ENSMUSP00000058994","abundance":2.8,"rank":7337,"name":"Ferd3l","annotation":"Fer3-like protein; Transcription factor that binds to the E-box and functions as inhibitor of transcription. DNA binding requires dimerization with an E protein. Inhibits transcription activation by ASCL1/MASH1 by sequestering E proteins."},{"id":"ENSMUSP00000112430","abundance":2.8,"rank":7338,"name":"Fgfr2","annotation":"Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell p [...] "},{"id":"ENSMUSP00000157352","abundance":2.8,"rank":7339,"name":"Slc24a4","annotation":"Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis."},{"id":"ENSMUSP00000101686","abundance":2.8,"rank":7340,"name":"Zfp362","annotation":"Zinc finger protein 362."},{"id":"ENSMUSP00000032747","abundance":2.8,"rank":7341,"name":"Hddc3","annotation":"Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; ppGpp hydrolyzing enzyme involved in starvation response."},{"id":"ENSMUSP00000025065","abundance":2.8,"rank":7342,"name":"Nudt12","annotation":"Peroxisomal NADH pyrophosphatase NUDT12; Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Belongs to the Nudix hydrolase family. NudC subfamily."},{"id":"ENSMUSP00000029871","abundance":2.8,"rank":7343,"name":"Cdh17","annotation":"Cadherin-17; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine."},{"id":"ENSMUSP00000106444","abundance":2.8,"rank":7344,"name":"Ppp1r14d","annotation":"Protein phosphatase 1 regulatory subunit 14D; Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity)."},{"id":"ENSMUSP00000055048","abundance":2.79,"rank":7345,"name":"Nrsn1","annotation":"Neurensin-1; May play an important role in neural organelle transport, and in transduction of nerve signals or in nerve growth. May play a role in neurite extension."},{"id":"ENSMUSP00000021157","abundance":2.79,"rank":7346,"name":"Med31","annotation":"Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000129169","abundance":2.79,"rank":7347,"name":"Abhd6","annotation":"Monoacylglycerol lipase ABHD6; Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol. Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids. Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formati [...] "},{"id":"ENSMUSP00000102776","abundance":2.79,"rank":7348,"name":"Slc24a2","annotation":"Solute carrier family 24 (sodium/potassium/calcium exchanger), member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family."},{"id":"ENSMUSP00000084910","abundance":2.79,"rank":7349,"name":"Htra3","annotation":"Serine protease HTRA3; Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF- beta family proteins possibly indirectly by degradation of these ECM proteoglycans. May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity)."},{"id":"ENSMUSP00000146824","abundance":2.79,"rank":7350,"name":"Zfp14","annotation":"Zinc finger protein 14; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000109049","abundance":2.79,"rank":7351,"name":"Hdx","annotation":"Highly divergent homeobox."},{"id":"ENSMUSP00000058050","abundance":2.79,"rank":7352,"name":"Lingo4","annotation":"Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4."},{"id":"ENSMUSP00000150523","abundance":2.79,"rank":7353,"name":"Mrln","annotation":"Myoregulin; Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle."},{"id":"ENSMUSP00000072155","abundance":2.79,"rank":7354,"name":"Usp13","annotation":"Ubiquitin carboxyl-terminal hydrolase 13; Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum-associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34- containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34-containing complexes regulate USP13 st [...] "},{"id":"ENSMUSP00000047235","abundance":2.78,"rank":7355,"name":"Hpf1","annotation":"Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine. Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity o [...] "},{"id":"ENSMUSP00000095732","abundance":2.78,"rank":7356,"name":"Gm21541","annotation":"Predicted gene, 21541."},{"id":"ENSMUSP00000136267","abundance":2.78,"rank":7357,"name":"Ccl21b","annotation":"C-C motif chemokine 21c."},{"id":"ENSMUSP00000137398","abundance":2.78,"rank":7358,"name":"Ccl21b-3","annotation":"C-C motif chemokine 21b."},{"id":"ENSMUSP00000137149","abundance":2.78,"rank":7359,"name":"Ccl21b-2","annotation":"Chemokine (C-C motif) ligand 21B (leucine)."},{"id":"ENSMUSP00000136903","abundance":2.78,"rank":7360,"name":"Gm10591","annotation":"Predicted gene 10591."},{"id":"ENSMUSP00000137555","abundance":2.78,"rank":7361,"name":"Ccl21b-4","annotation":"C-C motif chemokine 21c."},{"id":"ENSMUSP00000095727","abundance":2.78,"rank":7362,"name":"Gm13304","annotation":"C-C motif chemokine 21b; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs."},{"id":"ENSMUSP00000131207","abundance":2.78,"rank":7363,"name":"Eefsec","annotation":"Selenocysteine-specific elongation factor; Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. SelB subfamily."},{"id":"ENSMUSP00000146090","abundance":2.78,"rank":7364,"name":"Hapln3","annotation":"Hyaluronan and proteoglycan link protein 3; May function in hyaluronic acid binding. Belongs to the HAPLN family."},{"id":"ENSMUSP00000036740","abundance":2.78,"rank":7365,"name":"Ninj1","annotation":"Ninjurin-1; Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations (By similarity)."},{"id":"ENSMUSP00000025707","abundance":2.78,"rank":7366,"name":"Zfpl1","annotation":"Zinc finger protein-like 1; Required for cis-Golgi integrity and efficient ER to Golgi transport. Involved in the maintenance of the integrity of the cis- Golgi, possibly via its interaction with GOLGA2/GM130 (By similarity). Belongs to the ZFPL1 family."},{"id":"ENSMUSP00000002487","abundance":2.78,"rank":7367,"name":"Braf","annotation":"Serine/threonine-protein kinase B-raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. May play a role in the postsynaptic responses of hippocampal neurons."},{"id":"ENSMUSP00000124863","abundance":2.78,"rank":7368,"name":"Zmiz1","annotation":"Zinc finger MIZ domain-containing protein 1; Acts as transcriptional coactivator. Increases ligand- dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (By similarity). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (By similarity). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development."},{"id":"ENSMUSP00000052328","abundance":2.78,"rank":7369,"name":"Ssu2","annotation":"Protein SSUH2 homolog; Plays a role in odontogenesis."},{"id":"ENSMUSP00000045191","abundance":2.77,"rank":7370,"name":"Prss23","annotation":"Serine protease 23."},{"id":"ENSMUSP00000063933","abundance":2.77,"rank":7371,"name":"Chl1","annotation":"Processed neural cell adhesion molecule L1-like protein; Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons as well as in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependen [...] "},{"id":"ENSMUSP00000049038","abundance":2.77,"rank":7372,"name":"Ep400","annotation":"E1A-binding protein p400; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the associ [...] "},{"id":"ENSMUSP00000031037","abundance":2.77,"rank":7373,"name":"Slc30a3","annotation":"Zinc transporter 3; Involved in accumulation of zinc in synaptic vesicles."},{"id":"ENSMUSP00000030361","abundance":2.77,"rank":7374,"name":"Tmem59","annotation":"Transmembrane protein 59; Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding."},{"id":"ENSMUSP00000127149","abundance":2.77,"rank":7375,"name":"Pnpla2","annotation":"Patatin-like phospholipase domain-containing protein 2; Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion."},{"id":"ENSMUSP00000093462","abundance":2.77,"rank":7376,"name":"Pole4","annotation":"DNA polymerase epsilon subunit 4; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity)."},{"id":"ENSMUSP00000126567","abundance":2.77,"rank":7377,"name":"H2al2c","annotation":"Histone H2A; Belongs to the histone H2A family."},{"id":"ENSMUSP00000132924","abundance":2.77,"rank":7378,"name":"H2al2b","annotation":"H2A histone family member L2B."},{"id":"ENSMUSP00000059538","abundance":2.77,"rank":7379,"name":"Dok7","annotation":"Protein Dok-7; Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK."},{"id":"ENSMUSP00000130711","abundance":2.77,"rank":7380,"name":"AU015836","annotation":"Expressed sequence AU015836."},{"id":"ENSMUSP00000103718","abundance":2.77,"rank":7381,"name":"Scgb1b30","annotation":"Secretoglobin, family 1B, member 30."},{"id":"ENSMUSP00000003981","abundance":2.77,"rank":7382,"name":"Il7r","annotation":"Interleukin-7 receptor subunit alpha; Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)."},{"id":"ENSMUSP00000128718","abundance":2.77,"rank":7383,"name":"Col9a3","annotation":"Collagen, type IX, alpha 3."},{"id":"ENSMUSP00000108786","abundance":2.76,"rank":7384,"name":"Rab3il1","annotation":"Guanine nucleotide exchange factor for Rab-3A; Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activates RAB8A and RAB8B (By similarity)."},{"id":"ENSMUSP00000057515","abundance":2.76,"rank":7385,"name":"Zbtb12","annotation":"Zinc finger and BTB domain-containing 12."},{"id":"ENSMUSP00000019906","abundance":2.76,"rank":7386,"name":"Vip","annotation":"Vasoactive intestinal peptide; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder."},{"id":"ENSMUSP00000151606","abundance":2.76,"rank":7387,"name":"Gm9040","annotation":"Predicted gene 9040."},{"id":"ENSMUSP00000151369","abundance":2.76,"rank":7388,"name":"Gm9044","annotation":"Predicted gene 9040."},{"id":"ENSMUSP00000151963","abundance":2.76,"rank":7389,"name":"Gm9046","annotation":"Predicted gene 9046."},{"id":"ENSMUSP00000026322","abundance":2.76,"rank":7390,"name":"Polr3a","annotation":"DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates."},{"id":"ENSMUSP00000102690","abundance":2.76,"rank":7391,"name":"Gjc1","annotation":"Gap junction gamma-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Gamma-type subfamily."},{"id":"ENSMUSP00000040936","abundance":2.76,"rank":7392,"name":"Cdk19","annotation":"Cyclin-dependent kinase 19; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."},{"id":"ENSMUSP00000022269","abundance":2.76,"rank":7393,"name":"Oit1","annotation":"Protein FAM3D."},{"id":"ENSMUSP00000098942","abundance":2.76,"rank":7394,"name":"Chac2","annotation":"Putative glutathione-specific gamma-glutamylcyclotransferase 2; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (By similarity). Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily."},{"id":"ENSMUSP00000056015","abundance":2.76,"rank":7395,"name":"Tent5b","annotation":"Terminal nucleotidyltransferase 5B; Probable nucleotidyltransferase that may act as a non- canonical poly(A) RNA polymerase."},{"id":"ENSMUSP00000070898","abundance":2.76,"rank":7396,"name":"Gm9955","annotation":"Predicted gene 9955."},{"id":"ENSMUSP00000076871","abundance":2.75,"rank":7397,"name":"Ccdc148","annotation":"Coiled-coil domain-containing protein 148."},{"id":"ENSMUSP00000021519","abundance":2.75,"rank":7398,"name":"Six6","annotation":"Homeobox protein SIX6; May be involved in eye development."},{"id":"ENSMUSP00000039178","abundance":2.75,"rank":7399,"name":"Relch","annotation":"RAB11-binding protein RELCH; Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP. Functions in membrane tethering and promotes OSBP- mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes."},{"id":"ENSMUSP00000022813","abundance":2.75,"rank":7400,"name":"Efs","annotation":"Embryonal Fyn-associated substrate; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May serve as an activator of SRC and a downstream effector. Interacts with the SH3 domain of FYN and with CRK, SRC, and YES."},{"id":"ENSMUSP00000126061","abundance":2.75,"rank":7401,"name":"Wdr4","annotation":"tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit (By similarity). Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also required for the formation of N(7)- methylguanine at internal sites in a subset of mRNAs (By similarity). Also required for  [...] "},{"id":"ENSMUSP00000028100","abundance":2.75,"rank":7402,"name":"Epc1","annotation":"Enhancer of polycomb homolog 1; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replica [...] "},{"id":"ENSMUSP00000003438","abundance":2.75,"rank":7403,"name":"Mob3a","annotation":"MOB kinase activator 3A; May regulate the activity of kinases."},{"id":"ENSMUSP00000039416","abundance":2.75,"rank":7404,"name":"Exoc3","annotation":"Exocyst complex component 3; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane."},{"id":"ENSMUSP00000114927","abundance":2.75,"rank":7405,"name":"Grm5","annotation":"Metabotropic glutamate receptor 5; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity (By similarity)."},{"id":"ENSMUSP00000078623","abundance":2.75,"rank":7406,"name":"Cyb5d2","annotation":"Neuferricin; Heme-binding protein which promotes neuronal but not astrocyte differentiation."},{"id":"ENSMUSP00000043783","abundance":2.75,"rank":7407,"name":"Resp18","annotation":"Regulated endocrine-specific protein 18; May play an important regulatory role in corticotrophs; Belongs to the RESP18 family."},{"id":"ENSMUSP00000057275","abundance":2.74,"rank":7408,"name":"Rspry1","annotation":"RING finger and SPRY domain-containing protein 1."},{"id":"ENSMUSP00000096491","abundance":2.74,"rank":7409,"name":"Defa5","annotation":"Alpha-defensin 5."},{"id":"ENSMUSP00000077259","abundance":2.74,"rank":7410,"name":"Defa35","annotation":"Alpha-defensin 5; Probably contributes to the antimicrobial barrier function of the small bowel mucosa; Belongs to the alpha-defensin family."},{"id":"ENSMUSP00000074745","abundance":2.74,"rank":7411,"name":"Defa34","annotation":"Defensin, alpha, 34."},{"id":"ENSMUSP00000035166","abundance":2.74,"rank":7412,"name":"Uba5","annotation":"Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2. Belongs to the ubiquitin-activating E1 family. UBA5 subfamily."},{"id":"ENSMUSP00000107231","abundance":2.74,"rank":7413,"name":"Tdrd1","annotation":"Tudor domain-containing protein 1; Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of corr [...] "},{"id":"ENSMUSP00000151313","abundance":2.74,"rank":7414,"name":"Cd63","annotation":"CD63 antigen; Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal tr [...] "},{"id":"ENSMUSP00000063061","abundance":2.74,"rank":7415,"name":"Pnma5","annotation":"Paraneoplastic antigen-like protein 5."},{"id":"ENSMUSP00000156794","abundance":2.74,"rank":7416,"name":"Armc12","annotation":"Armadillo repeat-containing protein 12."},{"id":"ENSMUSP00000062441","abundance":2.73,"rank":7417,"name":"Clec4a1","annotation":"C-type lectin domain family 4, member a1."},{"id":"ENSMUSP00000035989","abundance":2.73,"rank":7418,"name":"Ipo13","annotation":"Importin-13; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...] "},{"id":"ENSMUSP00000060499","abundance":2.73,"rank":7419,"name":"Samd10","annotation":"Sterile alpha motif domain-containing protein 10."},{"id":"ENSMUSP00000145740","abundance":2.73,"rank":7420,"name":"Gp6","annotation":"Platelet glycoprotein VI; Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2."},{"id":"ENSMUSP00000023906","abundance":2.73,"rank":7421,"name":"Reg2","annotation":"Lithostathine-2; Might act as an inhibitor of spontaneous calcium carbonate precipitation."},{"id":"ENSMUSP00000004094","abundance":2.73,"rank":7422,"name":"Ssbp2","annotation":"Single-stranded DNA-binding protein 2."},{"id":"ENSMUSP00000103357","abundance":2.73,"rank":7423,"name":"Cyth2","annotation":"Cytohesin-2; Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth."},{"id":"ENSMUSP00000044808","abundance":2.73,"rank":7424,"name":"Efcab11","annotation":"EF-hand calcium-binding domain-containing protein 11."},{"id":"ENSMUSP00000055362","abundance":2.73,"rank":7425,"name":"Myo3b","annotation":"Myosin-IIIb; Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends [...] "},{"id":"ENSMUSP00000024026","abundance":2.73,"rank":7426,"name":"Cypt1","annotation":"Cysteine-rich perinuclear theca protein 1."},{"id":"ENSMUSP00000112915","abundance":2.73,"rank":7427,"name":"Etv3","annotation":"ETS translocation variant 3; Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity; Belongs to the ETS family."},{"id":"ENSMUSP00000050933","abundance":2.72,"rank":7428,"name":"Nkx2-3","annotation":"Homeobox protein Nkx-2.3; Transcriptional regulator essential for normal development and functions of the small intestine and spleen. Activates directly MADCAM1 expression. Required for homing of lymphocytes in spleen and mucosa-associated lymphoid tissue. May have a role during pharyngeal organogenesis; Belongs to the NK-2 homeobox family."},{"id":"ENSMUSP00000053899","abundance":2.72,"rank":7429,"name":"Mafg","annotation":"Transcription factor MafG; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1 and NFE2L2, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NFE2L2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NFE2L2. Activates globin g [...] "},{"id":"ENSMUSP00000117014","abundance":2.72,"rank":7430,"name":"Alas1","annotation":"5-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family."},{"id":"ENSMUSP00000129481","abundance":2.72,"rank":7431,"name":"Rabggtb","annotation":"Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A."},{"id":"ENSMUSP00000069112","abundance":2.72,"rank":7432,"name":"Fam122b","annotation":"Protein FAM122B."},{"id":"ENSMUSP00000024810","abundance":2.72,"rank":7433,"name":"Fgd2","annotation":"FYVE, RhoGEF and PH domain-containing protein 2; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5- monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate."},{"id":"ENSMUSP00000124031","abundance":2.72,"rank":7434,"name":"Ttc16","annotation":"Tetratricopeptide repeat protein 16."},{"id":"ENSMUSP00000096484","abundance":2.72,"rank":7435,"name":"Lce3e","annotation":"Late cornified envelope 3E."},{"id":"ENSMUSP00000022751","abundance":2.71,"rank":7436,"name":"Ttc33","annotation":"Tetratricopeptide repeat protein 33."},{"id":"ENSMUSP00000033952","abundance":2.71,"rank":7437,"name":"Sfrp1","annotation":"Secreted frizzled-related protein 1; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By simila [...] "},{"id":"ENSMUSP00000035539","abundance":2.71,"rank":7438,"name":"Spib","annotation":"Transcription factor Spi-B; Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation."},{"id":"ENSMUSP00000084082","abundance":2.71,"rank":7439,"name":"Yju2","annotation":"Splicing factor YJU2; Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex."},{"id":"ENSMUSP00000029268","abundance":2.71,"rank":7440,"name":"1810062G17Rik","annotation":"RIKEN cDNA 1810062G17 gene."},{"id":"ENSMUSP00000017552","abundance":2.71,"rank":7441,"name":"Cacnb1","annotation":"Voltage-dependent L-type calcium channel subunit beta-1; Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore- forming subunit (By similarity). Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (By simi [...] "},{"id":"ENSMUSP00000047150","abundance":2.71,"rank":7442,"name":"Cyp2g1","annotation":"Cytochrome P450, family 2, subfamily g, polypeptide 1; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000034231","abundance":2.71,"rank":7443,"name":"Ccl22","annotation":"C-C motif chemokine 22; Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B- lymphocytes with T-cells in immune responses."},{"id":"ENSMUSP00000147942","abundance":2.71,"rank":7444,"name":"Gm45808","annotation":"Predicted gene 45808."},{"id":"ENSMUSP00000028763","abundance":2.71,"rank":7445,"name":"Tyro3","annotation":"Tyrosine-protein kinase receptor TYRO3; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival  [...] "},{"id":"ENSMUSP00000049146","abundance":2.71,"rank":7446,"name":"Edc3","annotation":"Enhancer of mRNA-decapping protein 3; Binds single-stranded RNA. Involved in the process of mRNA degradation and in the positive regulation of mRNA decapping (By similarity); Belongs to the EDC3 family."},{"id":"ENSMUSP00000026649","abundance":2.71,"rank":7447,"name":"Syngr2","annotation":"Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane."},{"id":"ENSMUSP00000002298","abundance":2.71,"rank":7448,"name":"Ppm1j","annotation":"Protein phosphatase 1J; Belongs to the PP2C family."},{"id":"ENSMUSP00000030102","abundance":2.7,"rank":7449,"name":"Kdm4c","annotation":"Lysine-specific demethylase 4C; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate (By similarity)."},{"id":"ENSMUSP00000014743","abundance":2.7,"rank":7450,"name":"Csf1","annotation":"Processed macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male a [...] "},{"id":"ENSMUSP00000154725","abundance":2.7,"rank":7451,"name":"Rabggta","annotation":"Geranylgeranyl transferase type-2 subunit alpha; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A; Belongs to the protein prenyltransferase subunit alpha family."},{"id":"ENSMUSP00000145192","abundance":2.7,"rank":7452,"name":"Zfp775","annotation":"Zinc finger protein 775; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000086204","abundance":2.7,"rank":7453,"name":"Mapk11","annotation":"Mitogen-activated protein kinase 11; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK11 functions are mostly redundant with those of MA [...] "},{"id":"ENSMUSP00000036360","abundance":2.7,"rank":7454,"name":"Tspyl4","annotation":"Testis-specific Y-encoded-like protein 4; Belongs to the nucleosome assembly protein (NAP) family."},{"id":"ENSMUSP00000124520","abundance":2.7,"rank":7455,"name":"Prrt2","annotation":"Proline-rich transmembrane protein 2; As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and downregulate short-term facilitation ; Belongs to the CD225/Dispanin family."},{"id":"ENSMUSP00000045354","abundance":2.7,"rank":7456,"name":"Nat14","annotation":"N-acetyltransferase 14; Probable acetyltransferase that binds the 5'-GGACTACAG-3' sequence of coproporphyrinogen oxidase promoter. Able to activate transcription of a reporter construct in vitro (By similarity). Belongs to the camello family."},{"id":"ENSMUSP00000072518","abundance":2.69,"rank":7457,"name":"Fam173a","annotation":"Adenine nucleotide translocase lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration. Probably also trimethylates ANT1/SLC25A4."},{"id":"ENSMUSP00000006718","abundance":2.69,"rank":7458,"name":"Wnt10a","annotation":"Protein Wnt-10a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Required for normal expression of KRT9 in foot plant epithelium. Requi [...] "},{"id":"ENSMUSP00000040286","abundance":2.69,"rank":7459,"name":"Anapc15","annotation":"Anaphase-promoting complex subunit 15; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20 (By similarity)."},{"id":"ENSMUSP00000035498","abundance":2.69,"rank":7460,"name":"Fntb","annotation":"Protein farnesyltransferase subunit beta; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X."},{"id":"ENSMUSP00000032260","abundance":2.69,"rank":7461,"name":"Clec2d","annotation":"C-type lectin domain family 2 member D; Receptor for KLRB1B that protects target cells against natural killer cell-mediated lysis. Inhibits osteoclast formation. Binds high molecular weight sulfated glycosaminoglycans."},{"id":"ENSMUSP00000062832","abundance":2.69,"rank":7462,"name":"Dppa3","annotation":"Developmental pluripotency-associated protein 3; Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) o [...] "},{"id":"ENSMUSP00000056182","abundance":2.69,"rank":7463,"name":"Slc17a5","annotation":"Sialin; Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva (By similarity)."},{"id":"ENSMUSP00000053397","abundance":2.69,"rank":7464,"name":"Zfp319","annotation":"Zinc finger protein 319; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000034777","abundance":2.69,"rank":7465,"name":"Calml4","annotation":"Calmodulin-like protein 4."},{"id":"ENSMUSP00000036726","abundance":2.69,"rank":7466,"name":"Ascc3","annotation":"Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation."},{"id":"ENSMUSP00000107985","abundance":2.69,"rank":7467,"name":"Scn1a","annotation":"Sodium channel protein type 1 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. Plays a key role in brain, probably by regulating the moment when neurotransmitters are released in neurons. Involved in sensory perception of mechanical pain: activation in somatosensory neurons induces pain without neurogenic inflammatio [...] "},{"id":"ENSMUSP00000115558","abundance":2.69,"rank":7468,"name":"Rgs2","annotation":"Regulator of G-protein signaling 2; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (By similarity). It is involved in the negative regulation of the angiotensin-activated signaling pathway (By similarity). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle. Binds EIF2B5 and blocks i [...] "},{"id":"ENSMUSP00000107530","abundance":2.69,"rank":7469,"name":"Pprc1","annotation":"Peroxisome proliferator-activated receptor gamma coactivator-related protein 1; Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes (By similarity)."},{"id":"ENSMUSP00000037834","abundance":2.69,"rank":7470,"name":"Slc35b2","annotation":"Adenosine 3'-phospho 5'-phosphosulfate transporter 1; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi (By similarity)."},{"id":"ENSMUSP00000014891","abundance":2.69,"rank":7471,"name":"Ankrd53","annotation":"Ankyrin repeat domain-containing protein 53; Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization."},{"id":"ENSMUSP00000137065","abundance":2.69,"rank":7472,"name":"Wnt5b","annotation":"Protein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters; Belongs to the Wnt family."},{"id":"ENSMUSP00000151809","abundance":2.69,"rank":7473,"name":"Arhgap5","annotation":"Rho GTPase-activating protein 5; GTPase-activating protein for Rho family members."},{"id":"ENSMUSP00000059043","abundance":2.68,"rank":7474,"name":"Smtnl2","annotation":"Smoothelin-like protein 2; Belongs to the smoothelin family."},{"id":"ENSMUSP00000141980","abundance":2.68,"rank":7475,"name":"Crnn","annotation":"Cornulin."},{"id":"ENSMUSP00000058966","abundance":2.68,"rank":7476,"name":"Epb41l5","annotation":"Band 4.1-like protein 5; May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells."},{"id":"ENSMUSP00000093978","abundance":2.68,"rank":7477,"name":"Gng3","annotation":"Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000038382","abundance":2.68,"rank":7478,"name":"Nop14","annotation":"Nucleolar protein 14; Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity)."},{"id":"ENSMUSP00000147696","abundance":2.68,"rank":7479,"name":"Exosc6","annotation":"Exosome complex component MTR3; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytop [...] "},{"id":"ENSMUSP00000033973","abundance":2.68,"rank":7480,"name":"Rwdd4a","annotation":"RWD domain-containing protein 4."},{"id":"ENSMUSP00000034140","abundance":2.68,"rank":7481,"name":"Itfg1","annotation":"T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model."},{"id":"ENSMUSP00000112079","abundance":2.67,"rank":7482,"name":"Zfp2","annotation":"Zinc finger protein 2; Probable transcription factor involved in neuronal differentiation and/or phenotypic maintenance."},{"id":"ENSMUSP00000048126","abundance":2.67,"rank":7483,"name":"Gramd1b","annotation":"Protein Aster-B; Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER. Plays a crucial role in cholesterol homeostasis in the adrenal gland and has the unique ability to localize to the PM based on the level of membrane cholesterol. In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to  [...] "},{"id":"ENSMUSP00000028826","abundance":2.67,"rank":7484,"name":"Chgb","annotation":"Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides."},{"id":"ENSMUSP00000055542","abundance":2.67,"rank":7485,"name":"Trim16","annotation":"Tripartite motif-containing protein 16; E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative [...] "},{"id":"ENSMUSP00000065233","abundance":2.67,"rank":7486,"name":"C2cd2l","annotation":"Phospholipid transfer protein C2CD2L; Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (By similarity). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (By similarity). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two  [...] "},{"id":"ENSMUSP00000038568","abundance":2.67,"rank":7487,"name":"Dcaf15","annotation":"DDB1- and CUL4-associated factor 15; May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase."},{"id":"ENSMUSP00000138379","abundance":2.67,"rank":7488,"name":"Rbm5","annotation":"RNA-binding protein 5; Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes production of a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes production of a catalytically active form of CASP2/Cas [...] "},{"id":"ENSMUSP00000108096","abundance":2.67,"rank":7489,"name":"Fcamr","annotation":"High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM."},{"id":"ENSMUSP00000088047","abundance":2.67,"rank":7490,"name":"Cry2","annotation":"Cryptochrome-2; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] "},{"id":"ENSMUSP00000138958","abundance":2.67,"rank":7491,"name":"Csmd2","annotation":"CUB and Sushi multiple domains 2."},{"id":"ENSMUSP00000053147","abundance":2.66,"rank":7492,"name":"Barhl1","annotation":"BarH-like 1 homeobox protein; Belongs to the BAR homeobox family."},{"id":"ENSMUSP00000110508","abundance":2.66,"rank":7493,"name":"Cstdc4","annotation":"Cystatin domain-containing 4; Belongs to the cystatin family."},{"id":"ENSMUSP00000044675","abundance":2.66,"rank":7494,"name":"Fbxo34","annotation":"F-box only protein 34; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000092136","abundance":2.66,"rank":7495,"name":"Golt1a","annotation":"Vesicle transport protein GOT1A; May be involved in fusion of ER-derived transport vesicles with the Golgi complex; Belongs to the GOT1 family."},{"id":"ENSMUSP00000026927","abundance":2.66,"rank":7496,"name":"Nudt5","annotation":"ADP-sugar pyrophosphatase; Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (By similarity). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP- ribose to ATP and ribose 5-phosphate (By similarity). Nu [...] "},{"id":"ENSMUSP00000036704","abundance":2.66,"rank":7497,"name":"Tcte3","annotation":"Tctex1 domain-containing protein 3."},{"id":"ENSMUSP00000137218","abundance":2.66,"rank":7498,"name":"Gm3448","annotation":"Predicted gene 3448."},{"id":"ENSMUSP00000120461","abundance":2.66,"rank":7499,"name":"Ubl4a","annotation":"Ubiquitin-like protein 4A; As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches- containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthe [...] "},{"id":"ENSMUSP00000135312","abundance":2.66,"rank":7500,"name":"Six3","annotation":"Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] "},{"id":"ENSMUSP00000064547","abundance":2.66,"rank":7501,"name":"Pigw","annotation":"Phosphatidylinositol-glycan biosynthesis class W protein; Required for the transport of GPI-anchored proteins to the plasma membrane. Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI- anchor. Acetylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins."},{"id":"ENSMUSP00000074262","abundance":2.66,"rank":7502,"name":"Esx1","annotation":"Extraembryonic, spermatogenesis, homeobox 1."},{"id":"ENSMUSP00000118062","abundance":2.66,"rank":7503,"name":"Spx","annotation":"Spexin-1; Plays a role as a central modulator of cardiovascular and renal function and nociception. Plays also a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). [Spexin-2]: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity)."},{"id":"ENSMUSP00000099592","abundance":2.66,"rank":7504,"name":"Tcea3","annotation":"Transcription elongation factor A protein 3; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus."},{"id":"ENSMUSP00000033333","abundance":2.66,"rank":7505,"name":"Tmem9b","annotation":"Transmembrane protein 9B; Enhances production of proinflammatory cytokines induced by TNF, IL1B, and TLR ligands. Has a role in TNF activation of both the NF-kappaB and MAPK pathways."},{"id":"ENSMUSP00000097701","abundance":2.66,"rank":7506,"name":"Thap7","annotation":"THAP domain-containing protein 7; Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors."},{"id":"ENSMUSP00000043390","abundance":2.66,"rank":7507,"name":"Icmt","annotation":"Protein-S-isoprenylcysteine O-methyltransferase; Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family."},{"id":"ENSMUSP00000060985","abundance":2.65,"rank":7508,"name":"Olfm3","annotation":"Noelin-3."},{"id":"ENSMUSP00000108963","abundance":2.65,"rank":7509,"name":"Ubr2","annotation":"E3 ubiquitin-protein ligase UBR2; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity). Required for spermatogene [...] "},{"id":"ENSMUSP00000017576","abundance":2.65,"rank":7510,"name":"Rbfox3","annotation":"RNA binding protein fox-1 homolog 3; Pre-mRNA alternative splicing regulator. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD)."},{"id":"ENSMUSP00000100006","abundance":2.65,"rank":7511,"name":"Psd4","annotation":"PH and SEC7 domain-containing protein 4; Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II- containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 4,5-bisphosphate (By similarity)."},{"id":"ENSMUSP00000103248","abundance":2.65,"rank":7512,"name":"Sp6","annotation":"Transcription factor Sp6; Promotes cell proliferation; Belongs to the Sp1 C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000117963","abundance":2.65,"rank":7513,"name":"Rfx5","annotation":"DNA-binding protein Rfx5; Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. Belongs to the RFX family."},{"id":"ENSMUSP00000024015","abundance":2.65,"rank":7514,"name":"Guca2a","annotation":"Guanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins."},{"id":"ENSMUSP00000028838","abundance":2.65,"rank":7515,"name":"Hdc","annotation":"Histidine decarboxylase; Catalyzes the biosynthesis of histamine from histidine."},{"id":"ENSMUSP00000005889","abundance":2.65,"rank":7516,"name":"Vav1","annotation":"Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation."},{"id":"ENSMUSP00000138400","abundance":2.65,"rank":7517,"name":"Rbm6","annotation":"RNA-binding motif protein 6."},{"id":"ENSMUSP00000105995","abundance":2.65,"rank":7518,"name":"Zfp661","annotation":"Zinc finger protein 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000117496","abundance":2.65,"rank":7519,"name":"Mef2a","annotation":"Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] "},{"id":"ENSMUSP00000032109","abundance":2.65,"rank":7520,"name":"Ino80b","annotation":"INO80 complex subunit B; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair."},{"id":"ENSMUSP00000134303","abundance":2.65,"rank":7521,"name":"Mecom","annotation":"Histone-lysine N-methyltransferase MECOM."},{"id":"ENSMUSP00000130264","abundance":2.65,"rank":7522,"name":"Cmip","annotation":"C-Maf-inducing protein; Plays a role in T-cell signaling pathway."},{"id":"ENSMUSP00000125915","abundance":2.64,"rank":7523,"name":"Mad2l1bp","annotation":"MAD2L1-binding protein; May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex."},{"id":"ENSMUSP00000021338","abundance":2.64,"rank":7524,"name":"Ap4s1","annotation":"AP-4 complex subunit sigma-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper a [...] "},{"id":"ENSMUSP00000020579","abundance":2.64,"rank":7525,"name":"Hmmr","annotation":"Hyaluronan mediated motility receptor; Receptor for hyaluronic acid (HA). Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including the PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenesis."},{"id":"ENSMUSP00000029269","abundance":2.64,"rank":7526,"name":"Exosc9","annotation":"Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] "},{"id":"ENSMUSP00000137554","abundance":2.64,"rank":7527,"name":"Cfap73","annotation":"Cilia- and flagella-associated protein 73; May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm. Belongs to the CFAP73 family."},{"id":"ENSMUSP00000022218","abundance":2.64,"rank":7528,"name":"Dhfr","annotation":"Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA."},{"id":"ENSMUSP00000117410","abundance":2.64,"rank":7529,"name":"Smyd3","annotation":"Histone-lysine N-methyltransferase SMYD3; Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences."},{"id":"ENSMUSP00000142586","abundance":2.64,"rank":7530,"name":"Spink8","annotation":"Serine protease inhibitor Kazal-type 8; Probable serine protease inhibitor."},{"id":"ENSMUSP00000030763","abundance":2.64,"rank":7531,"name":"Cdk14","annotation":"Cyclin-dependent kinase 14; Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuro [...] "},{"id":"ENSMUSP00000095949","abundance":2.64,"rank":7532,"name":"Man2a2","annotation":"Alpha-mannosidase 2x; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway (By similarity)."},{"id":"ENSMUSP00000000266","abundance":2.64,"rank":7533,"name":"Ifi202b","annotation":"Interferon-activable protein 202; Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti- inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and inhibits the activation of the AIM2 inflammasome, probably by sequestering cytoplasmic DNA and preventing its being bound by AIM2; Belongs to the HIN-200 family."},{"id":"ENSMUSP00000063340","abundance":2.64,"rank":7534,"name":"Them7","annotation":"Novel Thioesterase superfamily domain and Saposin A-type domain containing protein (0610012H03Rik)."},{"id":"ENSMUSP00000021834","abundance":2.64,"rank":7535,"name":"Serpinb1c","annotation":"Leukocyte elastase inhibitor C; Regulates the activity of the neutrophil proteases. Forms only a stable complex with CTSG/Cathepsin G (By similarity). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. Belongs to the serpin family. Ov-serpin subfamily."},{"id":"ENSMUSP00000113429","abundance":2.63,"rank":7536,"name":"Rufy2","annotation":"RUN and FYVE domain-containing protein 2."},{"id":"ENSMUSP00000040134","abundance":2.63,"rank":7537,"name":"C330007P06Rik","annotation":"UPF0428 protein CXorf56 homolog."},{"id":"ENSMUSP00000086347","abundance":2.63,"rank":7538,"name":"Bpifb6","annotation":"BPI fold-containing family B member 6."},{"id":"ENSMUSP00000024159","abundance":2.63,"rank":7539,"name":"Dlx2","annotation":"Homeobox protein DLX-2; Acts as a transcriptional activator. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis ; Belongs to the distal-less homeobox family."},{"id":"ENSMUSP00000121079","abundance":2.63,"rank":7540,"name":"Pcp2","annotation":"Purkinje cell protein 2; May function as a cell-type specific modulator for G protein- mediated cell signaling."},{"id":"ENSMUSP00000125069","abundance":2.63,"rank":7541,"name":"Col22a1","annotation":"Collagen, type XXII, alpha 1."},{"id":"ENSMUSP00000109201","abundance":2.63,"rank":7542,"name":"Runx2","annotation":"Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transc [...] "},{"id":"ENSMUSP00000103080","abundance":2.63,"rank":7543,"name":"Fam174b","annotation":"Membrane protein FAM174B; Essential for Golgi structural integrity. Belongs to the FAM174 family."},{"id":"ENSMUSP00000127152","abundance":2.63,"rank":7544,"name":"Ear6","annotation":"Eosinophil-associated, ribonuclease A family, member 6; Belongs to the pancreatic ribonuclease family."},{"id":"ENSMUSP00000034162","abundance":2.63,"rank":7545,"name":"Pmfbp1","annotation":"Polyamine-modulated factor 1-binding protein 1; Required for normal spermatogenesis. It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity. May also be involved in the general organization of cellular cytoskeleton."},{"id":"ENSMUSP00000074009","abundance":2.63,"rank":7546,"name":"Ifnlr1","annotation":"Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal,  [...] "},{"id":"ENSMUSP00000022901","abundance":2.62,"rank":7547,"name":"Rrm2b","annotation":"Ribonucleoside-diphosphate reductase subunit M2 B; Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage."},{"id":"ENSMUSP00000031429","abundance":2.62,"rank":7548,"name":"P2rx4","annotation":"P2X purinoceptor 4; Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin (By similarity)."},{"id":"ENSMUSP00000112953","abundance":2.62,"rank":7549,"name":"Prpf39","annotation":"Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing."},{"id":"ENSMUSP00000126177","abundance":2.62,"rank":7550,"name":"Rgmb","annotation":"RGM domain family member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth (By similarity)."},{"id":"ENSMUSP00000030840","abundance":2.62,"rank":7551,"name":"Angptl7","annotation":"Angiopoietin-related protein 7; Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (By similarity). Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency."},{"id":"ENSMUSP00000086578","abundance":2.62,"rank":7552,"name":"Ccdc134","annotation":"Coiled-coil domain-containing protein 134; In extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function. Enhances cytotoxic anti-tumor activity of CD8(+) T cells. May inhibit ERK and JNK signaling activity. May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling. Belongs to the CCDC134 family."},{"id":"ENSMUSP00000094845","abundance":2.62,"rank":7553,"name":"C2cd6","annotation":"C2 calcium-dependent domain-containing 6."},{"id":"ENSMUSP00000095572","abundance":2.62,"rank":7554,"name":"Efcab7","annotation":"EF-hand calcium-binding domain-containing protein 7; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Required for the localization of the EVC2:EVC subcomplex at the base of primary cilia."},{"id":"ENSMUSP00000000329","abundance":2.62,"rank":7555,"name":"Alox12","annotation":"Arachidonate 12-lipoxygenase, 12S-type; Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. Mainly converts arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. In contrast does not react towards methyl esters of linoleic and arachidonic acids. Also catalyzes the epoxidation of double bonds of polyunsaturated fatty acids such as 14S-hydroperoxy-d [...] "},{"id":"ENSMUSP00000110057","abundance":2.62,"rank":7556,"name":"Satb2","annotation":"DNA-binding protein SATB2; Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double- stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for th [...] "},{"id":"ENSMUSP00000026595","abundance":2.62,"rank":7557,"name":"Tmem192","annotation":"Transmembrane protein 192."},{"id":"ENSMUSP00000001055","abundance":2.62,"rank":7558,"name":"Icam2","annotation":"Intercellular adhesion molecule 2; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance."},{"id":"ENSMUSP00000134530","abundance":2.61,"rank":7559,"name":"Gm20503","annotation":"Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction."},{"id":"ENSMUSP00000039632","abundance":2.61,"rank":7560,"name":"Osbpl11","annotation":"Oxysterol-binding protein-related protein 11; Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Belongs to the OSBP family."},{"id":"ENSMUSP00000112466","abundance":2.61,"rank":7561,"name":"Plekha8","annotation":"Pleckstrin homology domain-containing family A member 8; Cargo transport protein that is required for apical transport from the trans-Golgi network (TGN). Transports AQP2 from the trans- Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non- vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation [...] "},{"id":"ENSMUSP00000025243","abundance":2.61,"rank":7562,"name":"Iws1","annotation":"Protein IWS1 homolog; Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) [...] "},{"id":"ENSMUSP00000027565","abundance":2.61,"rank":7563,"name":"Serpinb3c","annotation":"Serine (Or cysteine) peptidase inhibitor, clade B, member 3C; Belongs to the serpin family."},{"id":"ENSMUSP00000029929","abundance":2.61,"rank":7564,"name":"Clca3a2","annotation":"Chloride channel calcium activated 2."},{"id":"ENSMUSP00000088727","abundance":2.61,"rank":7565,"name":"Usp9y","annotation":"Ubiquitin-specific peptidase 9, Y chromosome; Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000040332","abundance":2.61,"rank":7566,"name":"Prrx2","annotation":"Paired mesoderm homeobox protein 2; Belongs to the paired homeobox family."},{"id":"ENSMUSP00000037035","abundance":2.61,"rank":7567,"name":"Mindy2","annotation":"Ubiquitin carboxyl-terminal hydrolase MINDY-2; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. Can also bind to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys- 33' and 'Lys-63'. May play a regulatory role at the level of protein turnover."},{"id":"ENSMUSP00000035683","abundance":2.61,"rank":7568,"name":"Ptcra","annotation":"Pre T-cell antigen receptor alpha; The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3- TCRB complex."},{"id":"ENSMUSP00000077878","abundance":2.61,"rank":7569,"name":"Il15ra","annotation":"Soluble interleukin-15 receptor subunit alpha; High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. In neutrophils, binds and activates kinase SYK in response to IL15 stimulation (By similarity). In neutrophils, required for IL15-induced phagocytosis in a SYK-dependent manner (By similarity)."},{"id":"ENSMUSP00000108159","abundance":2.61,"rank":7570,"name":"Zfp932","annotation":"Zinc finger protein 431; Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1."},{"id":"ENSMUSP00000035400","abundance":2.61,"rank":7571,"name":"Nckap1l","annotation":"Nck-associated protein 1-like; Essential hematopoietic-specific regulator of the actin cytoskeleton. Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages. Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells. Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Al [...] "},{"id":"ENSMUSP00000034554","abundance":2.61,"rank":7572,"name":"Pou2af1","annotation":"POU domain class 2-associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers."},{"id":"ENSMUSP00000124272","abundance":2.6,"rank":7573,"name":"Unc93b1","annotation":"Protein unc-93 homolog B1; Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal."},{"id":"ENSMUSP00000113979","abundance":2.6,"rank":7574,"name":"Ido2","annotation":"Indoleamine 2,3-dioxygenase 2; Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Involved in immune regulation."},{"id":"ENSMUSP00000125651","abundance":2.6,"rank":7575,"name":"AI837181","annotation":"UPF0696 protein C11orf68 homolog."},{"id":"ENSMUSP00000040524","abundance":2.6,"rank":7576,"name":"Aicda","annotation":"Single-stranded DNA cytosine deaminase; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation."},{"id":"ENSMUSP00000086450","abundance":2.6,"rank":7577,"name":"Nudt18","annotation":"8-oxo-dGDP phosphatase NUDT18; Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools (By similarity); Belongs to the Nudix hydrolase family."},{"id":"ENSMUSP00000127292","abundance":2.6,"rank":7578,"name":"Cdhr5","annotation":"Cadherin-related family member 5; Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation."},{"id":"ENSMUSP00000147664","abundance":2.6,"rank":7579,"name":"Olfr573-ps1","annotation":"Olfactory receptor 573, pseudogene 1."},{"id":"ENSMUSP00000110371","abundance":2.6,"rank":7580,"name":"Cacnb2","annotation":"Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting."},{"id":"ENSMUSP00000087114","abundance":2.6,"rank":7581,"name":"Rubcn","annotation":"Run domain Beclin-1-interacting and cysteine-rich domain-containing protein; Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (By similarity)."},{"id":"ENSMUSP00000024056","abundance":2.6,"rank":7582,"name":"Ube2j2","annotation":"Ubiquitin-conjugating enzyme E2 J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000048809","abundance":2.6,"rank":7583,"name":"Ttll5","annotation":"Tubulin polyglutamylase TTLL5; Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for CCSAP localization to both spindle and cilia microtubules (By similarity). Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction (By similarity). Belongs to the tubulin--tyrosine ligase family."},{"id":"ENSMUSP00000061835","abundance":2.6,"rank":7584,"name":"N6amt1","annotation":"Methyltransferase N6AMT1; Methyltransferase that can methylate both proteins and DNA, and to a lower extent, arsenic. Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5- methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif. Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. Also acts as a N(6)-adenine- specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (By similarity). N(6)- methyladenosine (m6A) DNA is significantly [...] "},{"id":"ENSMUSP00000043279","abundance":2.6,"rank":7585,"name":"Zdhhc17","annotation":"Palmitoyltransferase ZDHHC17; Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (By similarity). May play a role in Mg(2+) transport (By similarity)."},{"id":"ENSMUSP00000060803","abundance":2.6,"rank":7586,"name":"Prr11","annotation":"Proline-rich protein 11; Plays a critical role in cell cycle progression."},{"id":"ENSMUSP00000082910","abundance":2.59,"rank":7587,"name":"Radil","annotation":"Ras-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development."},{"id":"ENSMUSP00000108889","abundance":2.59,"rank":7588,"name":"Cntn4","annotation":"Contactin-4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis; Belongs to the immunoglobulin superfamily. Contactin family."},{"id":"ENSMUSP00000059705","abundance":2.59,"rank":7589,"name":"Adra2c","annotation":"Alpha-2C adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins; Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily."},{"id":"ENSMUSP00000140453","abundance":2.59,"rank":7590,"name":"Gm20379","annotation":"Predicted gene, 20379."},{"id":"ENSMUSP00000003536","abundance":2.59,"rank":7591,"name":"Med29","annotation":"Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000098661","abundance":2.59,"rank":7592,"name":"Reps2","annotation":"RalBP1-associated Eps domain-containing protein 2; Involved in growth factor signaling through its influence on the Ral signaling pathway (By similarity). Interaction with ASAP1 may regulate cell migration."},{"id":"ENSMUSP00000038977","abundance":2.59,"rank":7593,"name":"Naa25","annotation":"N-alpha-acetyltransferase 25, NatB auxiliary subunit; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression. Belongs to the MDM20/NAA25 family."},{"id":"ENSMUSP00000020835","abundance":2.59,"rank":7594,"name":"Ppm1d","annotation":"Protein phosphatase 1D; Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation (By similarity). Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity."},{"id":"ENSMUSP00000097642","abundance":2.59,"rank":7595,"name":"Scn9a","annotation":"Sodium channel protein type 9 subunit alpha; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain ; Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.7/SCN9A subfamily."},{"id":"ENSMUSP00000139582","abundance":2.59,"rank":7596,"name":"H2al1b","annotation":"Histone H2A; Belongs to the histone H2A family."},{"id":"ENSMUSP00000062337","abundance":2.59,"rank":7597,"name":"Slc12a8","annotation":"Solute carrier family 12 member 8; Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation."},{"id":"ENSMUSP00000022499","abundance":2.59,"rank":7598,"name":"Rnaseh2b","annotation":"Ribonuclease H2 subunit B; Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes."},{"id":"ENSMUSP00000135924","abundance":2.59,"rank":7599,"name":"Tmem121b","annotation":"Transmembrane protein 121B; Belongs to the TMEM121 family."},{"id":"ENSMUSP00000049931","abundance":2.59,"rank":7600,"name":"Gm6377","annotation":"Predicted gene, EG622976."},{"id":"ENSMUSP00000064500","abundance":2.59,"rank":7601,"name":"Poglut2","annotation":"Protein O-glucosyltransferase 2; Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway."},{"id":"ENSMUSP00000075435","abundance":2.59,"rank":7602,"name":"Prp2","annotation":"Proline-rich protein 2."},{"id":"ENSMUSP00000096674","abundance":2.59,"rank":7603,"name":"Lekr1","annotation":"Leucine, glutamate and lysine-rich 1."},{"id":"ENSMUSP00000035291","abundance":2.59,"rank":7604,"name":"Tfb1m","annotation":"Dimethyladenosine transferase 1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily."},{"id":"ENSMUSP00000003574","abundance":2.59,"rank":7605,"name":"Cyp4f18","annotation":"Cytochrome P450 4F3; A cytochrome P450 monooxygenase involved in the metabolism of the proinflammatory lipid mediator leukotriene B4 (LTB4). Hydroxylates at the omega-1 and omega-2 positions LTB4. This oxidation step leads to LTB4 inactivation, which is postulated to be a crucial part of the resolution of inflammation. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)."},{"id":"ENSMUSP00000050978","abundance":2.59,"rank":7606,"name":"Slc35e4","annotation":"Solute carrier family 35 member E4; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily."},{"id":"ENSMUSP00000055757","abundance":2.59,"rank":7607,"name":"Pcsk9","annotation":"Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...] "},{"id":"ENSMUSP00000063784","abundance":2.58,"rank":7608,"name":"Adcyap1r1","annotation":"Pituitary adenylate cyclase-activating polypeptide type I receptor; This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract."},{"id":"ENSMUSP00000091002","abundance":2.58,"rank":7609,"name":"Irx3","annotation":"Iroquois-class homeodomain protein IRX-3; Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism."},{"id":"ENSMUSP00000095036","abundance":2.58,"rank":7610,"name":"Fndc1","annotation":"Fibronectin type III domain-containing 1."},{"id":"ENSMUSP00000028465","abundance":2.58,"rank":7611,"name":"P2rx3","annotation":"P2X purinoceptor 3; Receptor for ATP that acts as a ligand-gated cation channel (By similarity). Plays a role in sensory perception. Required for normal perception of pain. Required for normal taste perception ; Belongs to the P2X receptor family."},{"id":"ENSMUSP00000137439","abundance":2.58,"rank":7612,"name":"Atxn1","annotation":"Ataxin-1; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression (By similarity). May be involved in RNA metabolism (By similarity). In concert with CIC and ATXN1L, involved in brain development."},{"id":"ENSMUSP00000069751","abundance":2.58,"rank":7613,"name":"Dnah5","annotation":"Dynein heavy chain 5, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles. Belongs to the dynein heavy chain family."},{"id":"ENSMUSP00000046453","abundance":2.58,"rank":7614,"name":"Cars2","annotation":"Probable cysteine--tRNA ligase, mitochondrial."},{"id":"ENSMUSP00000113862","abundance":2.58,"rank":7615,"name":"Depdc5","annotation":"GATOR complex protein DEPDC5; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway."},{"id":"ENSMUSP00000005069","abundance":2.58,"rank":7616,"name":"Nmrk2","annotation":"Nicotinamide riboside kinase 2; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis (By similarity)."},{"id":"ENSMUSP00000096877","abundance":2.58,"rank":7617,"name":"Thbd","annotation":"Thrombomodulin; Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated."},{"id":"ENSMUSP00000050509","abundance":2.58,"rank":7618,"name":"Spata3","annotation":"Spermatogenesis-associated protein 3."},{"id":"ENSMUSP00000015749","abundance":2.58,"rank":7619,"name":"Srf","annotation":"Serum response factor; SRF is a transcription factor that binds to the serum response element (SRE), a short sequence of dyad symmetry located 300 bp to the 5' of the site of transcription initiation of some genes (such as FOS). Together with MRTFA transcription coactivator, controls expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. Required f [...] "},{"id":"ENSMUSP00000089036","abundance":2.58,"rank":7620,"name":"Nr2f1","annotation":"COUP transcription factor 1; Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG (By similarity); Belongs to the nuclear hormone receptor family. NR2 subfamily."},{"id":"ENSMUSP00000116608","abundance":2.58,"rank":7621,"name":"Wdr54","annotation":"WD repeat-containing protein 54; When cross-linked to form dimers and trimers, it has a regulatory effect on ERK signaling pathway activity in response to EGF stimulation. Colocalizes with the EGF receptor in WDR54-specific vesicle where it sustains the internalization and controls the degradation of the EGF receptor after EGF stimulation."},{"id":"ENSMUSP00000035784","abundance":2.58,"rank":7622,"name":"Angptl6","annotation":"Angiopoietin-related protein 6; May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure."},{"id":"ENSMUSP00000026635","abundance":2.58,"rank":7623,"name":"Farp1","annotation":"FERM, ARHGEF and pleckstrin domain-containing protein 1; Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity)."},{"id":"ENSMUSP00000027961","abundance":2.58,"rank":7624,"name":"Hspa14","annotation":"Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state. In the RAC complex, binds to the nascent polypeptide chain, while DNAJC2 stimulates its ATPase activity (By similarity). Belongs to the heat shock protein 70 family."},{"id":"ENSMUSP00000112621","abundance":2.57,"rank":7625,"name":"Isg20","annotation":"Interferon-stimulated gene 20 kDa protein; Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses in an exonuclease- dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity)."},{"id":"ENSMUSP00000145481","abundance":2.57,"rank":7626,"name":"Gm44511","annotation":"Killer cell lectin-like receptor subfamily B member 1B allele A; Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells."},{"id":"ENSMUSP00000037627","abundance":2.57,"rank":7627,"name":"Trp53inp2","annotation":"Tumor protein p53-inducible nuclear protein 2; Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA."},{"id":"ENSMUSP00000102356","abundance":2.57,"rank":7628,"name":"Stk33","annotation":"Serine/threonine-protein kinase 33; Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME."},{"id":"ENSMUSP00000071470","abundance":2.57,"rank":7629,"name":"Ifitm2","annotation":"Interferon-induced transmembrane protein 2; IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein- mediated viral entry. I [...] "},{"id":"ENSMUSP00000077150","abundance":2.57,"rank":7630,"name":"Tex101","annotation":"Testis-expressed protein 101; Plays a role in fertilization by controlling binding of sperm to zona pellucida and migration of spermatozoa into the oviduct probably through molecule adhesion ADAM3. May play a role in signal transduction and promote protein tyrosine phosphorylation (By similarity)."},{"id":"ENSMUSP00000071715","abundance":2.57,"rank":7631,"name":"Iqgap3","annotation":"IQ motif-containing GTPase-activating protein 3."},{"id":"ENSMUSP00000099388","abundance":2.57,"rank":7632,"name":"Nbr1","annotation":"Next to BRCA1 gene 1 protein; Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets."},{"id":"ENSMUSP00000022340","abundance":2.57,"rank":7633,"name":"Nid2","annotation":"Nidogen-2; Cell adhesion glycoprotein. Might be involved in osteoblast differentiation. It probably has a role in cell-extracellular matrix interactions."},{"id":"ENSMUSP00000113397","abundance":2.57,"rank":7634,"name":"Nyap1","annotation":"Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1; Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. Belongs to the NYAP family."},{"id":"ENSMUSP00000108254","abundance":2.57,"rank":7635,"name":"Galnt13","annotation":"Polypeptide N-acetylgalactosaminyltransferase 13; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a much stronger activity than GALNT1 to transfer GalNAc to mucin peptides, such as Muc5Ac and Muc7. Able to glycosylate SDC3. Probably responsible for the synthesis of Tn antigen in neuronal cells."},{"id":"ENSMUSP00000114906","abundance":2.57,"rank":7636,"name":"Coa7","annotation":"Cytochrome c oxidase assembly factor 7; Required for assembly of mitochondrial respiratory chain complex I and complex IV."},{"id":"ENSMUSP00000046981","abundance":2.57,"rank":7637,"name":"Ric8b","annotation":"Synembryn-B; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP (By similarity). Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction."},{"id":"ENSMUSP00000042098","abundance":2.57,"rank":7638,"name":"1700020L24Rik","annotation":"Uncharacterized protein C17orf50 homolog."},{"id":"ENSMUSP00000107262","abundance":2.57,"rank":7639,"name":"Xirp1","annotation":"Xin actin-binding repeat-containing protein 1; Protects actin filaments from depolymerization."},{"id":"ENSMUSP00000076751","abundance":2.56,"rank":7640,"name":"Cttnbp2nl","annotation":"CTTNBP2 N-terminal-like protein."},{"id":"ENSMUSP00000029806","abundance":2.56,"rank":7641,"name":"Dapp1","annotation":"Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide; May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K."},{"id":"ENSMUSP00000046131","abundance":2.56,"rank":7642,"name":"Fgl2","annotation":"Fibroleukin; Converts prothrombin to thrombin."},{"id":"ENSMUSP00000147497","abundance":2.56,"rank":7643,"name":"Slc8a2","annotation":"Sodium/calcium exchanger 2; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion."},{"id":"ENSMUSP00000023334","abundance":2.56,"rank":7644,"name":"Nectin3","annotation":"Nectin-3; Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans- interaction with NECTIN2 at Sertoli-spermatid junctions. Trans- interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morpholog [...] "},{"id":"ENSMUSP00000037257","abundance":2.56,"rank":7645,"name":"C1ql2","annotation":"Complement C1q-like protein 2; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses."},{"id":"ENSMUSP00000057871","abundance":2.56,"rank":7646,"name":"Slc25a44","annotation":"Solute carrier family 25 member 44; Mitochondrial solute transporter which transports branched- chain amino acid (BCAA; valine, leucine and isoleucine) into mitochondria in brown adipose tissue (BAT). BAT is involved in BCAA catabolism and actively utilizes BCAA in the mitochondria for thermogenesis."},{"id":"ENSMUSP00000078740","abundance":2.56,"rank":7647,"name":"Ugt2a2","annotation":"UDP-glucuronosyltransferase 2A2; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds."},{"id":"ENSMUSP00000031530","abundance":2.56,"rank":7648,"name":"Sppl3","annotation":"Signal peptide peptidase-like 3; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. Acts like a sheddase by mediating the proteolytic release and secretion of active site- containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1. Plays a role in the regulation of cellular glycosylation processes. Required to link T- cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the [...] "},{"id":"ENSMUSP00000129279","abundance":2.56,"rank":7649,"name":"Drosha","annotation":"Ribonuclease 3; Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri- miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Invo [...] "},{"id":"ENSMUSP00000027068","abundance":2.56,"rank":7650,"name":"Tram1","annotation":"Translocating chain-associated membrane protein 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane; Belongs to the TRAM family."},{"id":"ENSMUSP00000113603","abundance":2.56,"rank":7651,"name":"Lrrc8d","annotation":"Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel  [...] "},{"id":"ENSMUSP00000037278","abundance":2.56,"rank":7652,"name":"Ggact","annotation":"Gamma-glutamylaminecyclotransferase; Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl- alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine; Belongs to the gamma-glutamylcyclotransferase family."},{"id":"ENSMUSP00000070117","abundance":2.56,"rank":7653,"name":"Xlr4c","annotation":"X-linked lymphocyte-regulated 4C."},{"id":"ENSMUSP00000066171","abundance":2.56,"rank":7654,"name":"Xlr4b","annotation":"X-linked lymphocyte regulated gene 4."},{"id":"ENSMUSP00000045142","abundance":2.55,"rank":7655,"name":"Islr","annotation":"Immunoglobulin superfamily containing leucine-rich repeat protein."},{"id":"ENSMUSP00000097909","abundance":2.55,"rank":7656,"name":"Mrc2","annotation":"C-type mannose receptor 2; May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May participate in remodeling of extracellular matrix cooperating with the  [...] "},{"id":"ENSMUSP00000099522","abundance":2.55,"rank":7657,"name":"2510039O18Rik","annotation":"Uncharacterized protein KIAA2013."},{"id":"ENSMUSP00000141686","abundance":2.55,"rank":7658,"name":"Syngap1","annotation":"Ras/Rap GTPase-activating protein SynGAP; Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity)."},{"id":"ENSMUSP00000073525","abundance":2.55,"rank":7659,"name":"Ang4","annotation":"Angiogenin-4; Has bactericidal activity against E.faecalis and L.monocytogenes, but not against L.innocua and E.coli. Promotes angiogenesis (in vitro). Has low ribonuclease activity (in vitro). Promotes proliferation of melanoma cells, but not of endothelial cells or fibroblasts (in vitro)."},{"id":"ENSMUSP00000061700","abundance":2.55,"rank":7660,"name":"Pskh1","annotation":"Serine/threonine-protein kinase H1; May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing."},{"id":"ENSMUSP00000049176","abundance":2.55,"rank":7661,"name":"Patj","annotation":"InaD-like protein; Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane (By similarity). May regulate protein targeting, cell polarity and integrity of tight junctions (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries (By similarity)."},{"id":"ENSMUSP00000033218","abundance":2.55,"rank":7662,"name":"Rexo5","annotation":"RNA exonuclease 5."},{"id":"ENSMUSP00000041712","abundance":2.55,"rank":7663,"name":"Ifi27l2b","annotation":"Interferon alpha-inducible protein 27-like protein 2B; Functions in the intrinsic apoptotic signaling pathway and may have an interferon-induced antiviral activity. Belongs to the IFI6/IFI27 family."},{"id":"ENSMUSP00000136008","abundance":2.55,"rank":7664,"name":"Olfr332","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000032321","abundance":2.55,"rank":7665,"name":"Bcl2l14","annotation":"Apoptosis facilitator Bcl-2-like protein 14; Plays a role in apoptosis; Belongs to the Bcl-2 family."},{"id":"ENSMUSP00000105007","abundance":2.55,"rank":7666,"name":"Brd1","annotation":"Bromodomain-containing 1."},{"id":"ENSMUSP00000079799","abundance":2.55,"rank":7667,"name":"Krtap4-1","annotation":"Keratin associated protein 4-1."},{"id":"ENSMUSP00000031628","abundance":2.55,"rank":7668,"name":"Ptcd1","annotation":"Pentatricopeptide repeat-containing protein 1, mitochondrial; Mitochondrial protein implicated in negative regulation of leucine tRNA levels, as well as negative regulation of mitochondria- encoded proteins and COX activity. Affects also the 3'-processing of mitochondrial tRNAs."},{"id":"ENSMUSP00000034862","abundance":2.55,"rank":7669,"name":"Tmem266","annotation":"Transmembrane protein 266; Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum. Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear. Undergoes both rapid and slow structural rearrangements in response to changes in voltage. Contains a zinc-binding site that can regulate the slow conformational transition."},{"id":"ENSMUSP00000025912","abundance":2.55,"rank":7670,"name":"Plcb3","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes."},{"id":"ENSMUSP00000048844","abundance":2.55,"rank":7671,"name":"Cdrt4","annotation":"CMT1A duplicated region transcript 4 protein homolog."},{"id":"ENSMUSP00000113444","abundance":2.55,"rank":7672,"name":"Ngrn","annotation":"Neugrin; Plays an essential role in mitochondrial ribosome biogenesis. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation of core subunits of the oxidative phosphorylation system; Belongs to the neugrin family."},{"id":"ENSMUSP00000052129","abundance":2.54,"rank":7673,"name":"Tmem215","annotation":"Transmembrane protein 215."},{"id":"ENSMUSP00000114682","abundance":2.54,"rank":7674,"name":"Mettl16","annotation":"RNA N6-adenosine-methyltransferase METTL16; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl- L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (By similarity). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (By similarity). Plays a key role in S- adenosyl-L-methionine homeostasis by  [...] "},{"id":"ENSMUSP00000047488","abundance":2.54,"rank":7675,"name":"Klk1b26","annotation":"Kallikrein 1-related peptidase b26; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin."},{"id":"ENSMUSP00000109084","abundance":2.54,"rank":7676,"name":"Col4a3","annotation":"Collagen alpha-3(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen."},{"id":"ENSMUSP00000151574","abundance":2.54,"rank":7677,"name":"Arhgap9","annotation":"Rho GTPase-activating protein 9."},{"id":"ENSMUSP00000059224","abundance":2.54,"rank":7678,"name":"C1galt1c1","annotation":"C1GALT1-specific chaperone 1; Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3- galactosyltransferase (C1GALT1) (By similarity)."},{"id":"ENSMUSP00000104959","abundance":2.54,"rank":7679,"name":"Wfdc9","annotation":"Protein WFDC9."},{"id":"ENSMUSP00000096677","abundance":2.54,"rank":7680,"name":"Arfgef2","annotation":"Brefeldin A-inhibited guanine nucleotide-exchange protein 2; Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma  [...] "},{"id":"ENSMUSP00000066868","abundance":2.54,"rank":7681,"name":"Foxd2","annotation":"Forkhead box protein D2; Probable transcription factor involved in embryogenesis and somatogenesis."},{"id":"ENSMUSP00000044931","abundance":2.54,"rank":7682,"name":"Fanci","annotation":"Fanconi anemia group I protein homolog; Plays an essential role in the repair of DNA double-strand breaks by homologous recombination and in the repair of interstrand DNA cross-links (ICLs) by promoting FANCD2 monoubiquitination by FANCL and participating in recruitment to DNA repair sites. Required for maintenance of chromosomal stability. Specifically binds branched DNA: binds both single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). Participates in S phase and G2 phase checkpoint activation upon DNA damage."},{"id":"ENSMUSP00000131840","abundance":2.54,"rank":7683,"name":"Plxna1","annotation":"Plexin-A1; Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm."},{"id":"ENSMUSP00000159241","abundance":2.54,"rank":7684,"name":"Thoc2l","annotation":"THO complex subunit 2-like."},{"id":"ENSMUSP00000127784","abundance":2.54,"rank":7685,"name":"Nfat5","annotation":"Nuclear factor of activated T-cells 5; Transcription factor involved in the transcriptional regulation of osmoprotective and inflammatory genes. Regulates hypertonicity-induced cellular accumulation of osmolytes."},{"id":"ENSMUSP00000099443","abundance":2.54,"rank":7686,"name":"Skap1","annotation":"Src kinase-associated phosphoprotein 1; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. Belongs to the SKAP family."},{"id":"ENSMUSP00000052778","abundance":2.54,"rank":7687,"name":"Nkx1-2","annotation":"NK1 transcription factor-related protein 2; May function in cell specification, particularly in the CNS; Belongs to the NK-1 homeobox family."},{"id":"ENSMUSP00000103939","abundance":2.54,"rank":7688,"name":"Gem","annotation":"GTP-binding protein GEM; Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity; Belongs to the small GTPase superfamily. RGK family."},{"id":"ENSMUSP00000151397","abundance":2.54,"rank":7689,"name":"Izumo4","annotation":"Izumo sperm-egg fusion protein 4."},{"id":"ENSMUSP00000060858","abundance":2.54,"rank":7690,"name":"Polr1a","annotation":"DNA-directed RNA polymerase I subunit RPA1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation o [...] "},{"id":"ENSMUSP00000078269","abundance":2.54,"rank":7691,"name":"Nme5","annotation":"Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species."},{"id":"ENSMUSP00000029140","abundance":2.53,"rank":7692,"name":"Procr","annotation":"Endothelial protein C receptor; Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation."},{"id":"ENSMUSP00000027997","abundance":2.53,"rank":7693,"name":"Rgs5","annotation":"Regulator of G-protein signaling 5; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha."},{"id":"ENSMUSP00000130073","abundance":2.53,"rank":7694,"name":"Cyp39a1","annotation":"24-hydroxycholesterol 7-alpha-hydroxylase; A cytochrome P450 monooxygenase involved in neural cholesterol clearance through bile acid synthesis. Catalyzes 7-alpha hydroxylation of (24S)-hydroxycholesterol, a neural oxysterol that is metabolized to bile acids in the liver. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase)."},{"id":"ENSMUSP00000097422","abundance":2.53,"rank":7695,"name":"Olfr1164","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000110469","abundance":2.53,"rank":7696,"name":"C1qtnf5","annotation":"Complement C1q tumor necrosis factor-related protein 5."},{"id":"ENSMUSP00000009790","abundance":2.53,"rank":7697,"name":"Pla2g12b","annotation":"Group XIIB secretory phospholipase A2-like protein; Not known; does not seem to have catalytic activity."},{"id":"ENSMUSP00000030261","abundance":2.53,"rank":7698,"name":"2610528J11Rik","annotation":"Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane."},{"id":"ENSMUSP00000032480","abundance":2.53,"rank":7699,"name":"Ing4","annotation":"Inhibitor of growth protein 4; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact  [...] "},{"id":"ENSMUSP00000102015","abundance":2.53,"rank":7700,"name":"Rabep2","annotation":"Rab GTPase-binding effector protein 2; Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis. Belongs to the rabaptin family."},{"id":"ENSMUSP00000131406","abundance":2.53,"rank":7701,"name":"Ppp1r12b","annotation":"Protein phosphatase 1 regulatory subunit 12B; Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus (By similarity)."},{"id":"ENSMUSP00000113935","abundance":2.53,"rank":7702,"name":"1700016H13Rik","annotation":"Uncharacterized protein C4orf36 homolog."},{"id":"ENSMUSP00000124423","abundance":2.53,"rank":7703,"name":"Thnsl2","annotation":"Threonine synthase-like 2; Acts as a catabolic phospho-lyase on both gamma- and beta- phosphorylated substrates. Degrades O-phospho-threonine (PThr) to alpha-ketobutyrate, ammonia and phosphate. Also degrades O-phospho- homoserine (PHS), but this is not its physiological substrate. Belongs to the threonine synthase family."},{"id":"ENSMUSP00000047473","abundance":2.53,"rank":7704,"name":"Osgin2","annotation":"Oxidative stress-induced growth inhibitor family member 2."},{"id":"ENSMUSP00000023400","abundance":2.53,"rank":7705,"name":"Tmem114","annotation":"Transmembrane protein 114."},{"id":"ENSMUSP00000147829","abundance":2.53,"rank":7706,"name":"Ebf3","annotation":"Transcription factor COE3; Transcriptional activator. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity); Belongs to the COE family."},{"id":"ENSMUSP00000115668","abundance":2.53,"rank":7707,"name":"Speer3","annotation":"Spermatogenesis-associated glutamate (E)-rich protein 3."},{"id":"ENSMUSP00000032472","abundance":2.53,"rank":7708,"name":"Klrb1b","annotation":"Killer cell lectin-like receptor subfamily B member 1B allele B; Receptor for CLEC2D/OCIL. Ligand-binding contributes to inhibition of cytotoxic natural killer (NK) cells. May mediate MHC class I-independent 'missing-self' recognition of allografts, tumor cells and virus-infected cells."},{"id":"ENSMUSP00000028349","abundance":2.53,"rank":7709,"name":"Arrdc1","annotation":"Arrestin domain-containing protein 1; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (By similarity). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway ; Belongs to the arrest [...] "},{"id":"ENSMUSP00000134131","abundance":2.53,"rank":7710,"name":"Evx2","annotation":"Homeobox even-skipped homolog protein 2."},{"id":"ENSMUSP00000080209","abundance":2.52,"rank":7711,"name":"Oas2","annotation":"2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivi [...] "},{"id":"ENSMUSP00000123235","abundance":2.52,"rank":7712,"name":"C330021F23Rik","annotation":"Ribosomal protein S23, retrogene 1."},{"id":"ENSMUSP00000063376","abundance":2.52,"rank":7713,"name":"Spinkl","annotation":"Serine protease inhibitor kazal-like protein, major form; Does not function as an inhibitor of trypsin, chymotrypsin, subtilisin or elastase. Binds sperm and enhances sperm motility. May act as a decapacitation factor, suppresses BSA-stimulated sperm capacitation and blocks sperm-oocyte interactions in vitro."},{"id":"ENSMUSP00000054788","abundance":2.52,"rank":7714,"name":"Pgbd5","annotation":"PiggyBac transposable element-derived protein 5; Transposase that mediates sequence-specific genomic rearrangements."},{"id":"ENSMUSP00000135604","abundance":2.52,"rank":7715,"name":"Cers6","annotation":"Ceramide synthase 6; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor. Can use other acyl donors, but with less efficiency. Ceramides generated by CERS6 play a role in inflammatory response. Acts as a regulator of metabolism and hepatic lipid accumulation. Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the deve [...] "},{"id":"ENSMUSP00000072274","abundance":2.52,"rank":7716,"name":"Slc9a7","annotation":"Sodium/hydrogen exchanger 7; Mediates electroneutral exchange of protons for Na(+) and K(+) across endomembranes. May contribute to the regulation of Golgi apparatus volume and pH."},{"id":"ENSMUSP00000030622","abundance":2.52,"rank":7717,"name":"Syf2","annotation":"Pre-mRNA-splicing factor SYF2; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the SYF2 family."},{"id":"ENSMUSP00000128736","abundance":2.52,"rank":7718,"name":"Ccdc141","annotation":"Coiled-coil domain-containing 141."},{"id":"ENSMUSP00000022310","abundance":2.52,"rank":7719,"name":"Ngly1","annotation":"Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins [...] "},{"id":"ENSMUSP00000038983","abundance":2.52,"rank":7720,"name":"Washc2","annotation":"WASH complex subunit 2; Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation- promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex prob [...] "},{"id":"ENSMUSP00000113424","abundance":2.52,"rank":7721,"name":"Adamtsl4","annotation":"ADAMTS-like protein 4; Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis (By similarity)."},{"id":"ENSMUSP00000119715","abundance":2.52,"rank":7722,"name":"Rps6kb1","annotation":"Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] "},{"id":"ENSMUSP00000023171","abundance":2.52,"rank":7723,"name":"Hes1","annotation":"Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity)."},{"id":"ENSMUSP00000069231","abundance":2.52,"rank":7724,"name":"Tnfaip6","annotation":"Tumor necrosis factor-inducible gene 6 protein; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis."},{"id":"ENSMUSP00000152153","abundance":2.51,"rank":7725,"name":"Zbed3","annotation":"Zinc finger BED domain-containing protein 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression."},{"id":"ENSMUSP00000024783","abundance":2.51,"rank":7726,"name":"Bysl","annotation":"Bystin; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits; Belongs to the bystin family."},{"id":"ENSMUSP00000034051","abundance":2.51,"rank":7727,"name":"Ufsp2","annotation":"Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity); Belongs to the peptidase C78 family."},{"id":"ENSMUSP00000043562","abundance":2.51,"rank":7728,"name":"Pank1","annotation":"Pantothenate kinase 1; Plays a role in the physiological regulation of the intracellular CoA concentration; Belongs to the type II pantothenate kinase family."},{"id":"ENSMUSP00000110752","abundance":2.51,"rank":7729,"name":"Iqcg","annotation":"Dynein regulatory complex protein 9; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades (By similarity). Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and f [...] "},{"id":"ENSMUSP00000030254","abundance":2.51,"rank":7730,"name":"Leprot","annotation":"Leptin receptor gene-related protein; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability."},{"id":"ENSMUSP00000115090","abundance":2.51,"rank":7731,"name":"Gatc","annotation":"Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family."},{"id":"ENSMUSP00000027783","abundance":2.51,"rank":7732,"name":"Desi2","annotation":"Deubiquitinase DESI2; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'- linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization."},{"id":"ENSMUSP00000074115","abundance":2.51,"rank":7733,"name":"Gulp1","annotation":"PTB domain-containing engulfment adapter protein 1; Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization of various LRP1 ligands, such as PSAP (By similarity). May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Increases cellular levels of GTP-bound ARF6."},{"id":"ENSMUSP00000063114","abundance":2.51,"rank":7734,"name":"Prlhr","annotation":"Prolactin-releasing peptide receptor; Receptor for prolactin-releasing peptide (PrRP). Implicated in lactation, regulation of food intake and pain-signal processing. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000046920","abundance":2.51,"rank":7735,"name":"Uts2r","annotation":"Urotensin-2 receptor; High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity)."},{"id":"ENSMUSP00000026092","abundance":2.51,"rank":7736,"name":"3110040N11Rik","annotation":"UPF0235 protein C15orf40 homolog; Belongs to the UPF0235 family."},{"id":"ENSMUSP00000104363","abundance":2.51,"rank":7737,"name":"Drc3","annotation":"Dynein regulatory complex subunit 3; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes."},{"id":"ENSMUSP00000118046","abundance":2.51,"rank":7738,"name":"Myo7b","annotation":"Unconventional myosin-VIIb; Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. May link the complex to the actin core bundle of microvilli."},{"id":"ENSMUSP00000143145","abundance":2.51,"rank":7739,"name":"Gm49027","annotation":"Predicted gene, 49027."},{"id":"ENSMUSP00000053971","abundance":2.51,"rank":7740,"name":"Aasdhppt","annotation":"L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase; Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN (in vitro) (By similarity); Belongs to the P-Pant transferase superfamily. AcpS family."},{"id":"ENSMUSP00000026221","abundance":2.5,"rank":7741,"name":"Scd2","annotation":"Acyl-CoA desaturase 2; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides, especially during embryonic development and in neonates. Important for normal permeability barrier funct [...] "},{"id":"ENSMUSP00000037500","abundance":2.5,"rank":7742,"name":"Spem1","annotation":"Spermatid maturation protein 1; Required for proper cytoplasm removal during spermatogenesis."},{"id":"ENSMUSP00000106268","abundance":2.5,"rank":7743,"name":"Zmynd11","annotation":"Zinc finger MYND domain-containing protein 11; Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (By similarity). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth."},{"id":"ENSMUSP00000028977","abundance":2.5,"rank":7744,"name":"Kif3b","annotation":"Kinesin-like protein KIF3B, N-terminally processed; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro (By similarity); Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin II subfamily."},{"id":"ENSMUSP00000038110","abundance":2.5,"rank":7745,"name":"Sh3bgr","annotation":"SH3 domain-binding glutamic acid-rich protein; Belongs to the SH3BGR family."},{"id":"ENSMUSP00000111527","abundance":2.5,"rank":7746,"name":"Rbbp8","annotation":"DNA endonuclease RBBP8; Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection, the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice, as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phas [...] "},{"id":"ENSMUSP00000037007","abundance":2.5,"rank":7747,"name":"Hspb8","annotation":"Heat shock protein beta-8; Displays temperature-dependent chaperone activity; Belongs to the small heat shock protein (HSP20) family."},{"id":"ENSMUSP00000117384","abundance":2.5,"rank":7748,"name":"Asxl2","annotation":"Putative Polycomb group protein ASXL2; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility. Involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as peroxisome proliferator-activated  [...] "},{"id":"ENSMUSP00000071493","abundance":2.5,"rank":7749,"name":"Ovca2","annotation":"Esterase OVCA2; Belongs to the LovG family."},{"id":"ENSMUSP00000062412","abundance":2.49,"rank":7750,"name":"Hoxd10","annotation":"Homeobox protein Hox-D10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family."},{"id":"ENSMUSP00000090367","abundance":2.49,"rank":7751,"name":"Gm11559","annotation":"Predicted gene 11559."},{"id":"ENSMUSP00000121835","abundance":2.49,"rank":7752,"name":"Smchd1","annotation":"Structural maintenance of chromosomes flexible hinge domain-containing protein 1; Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture. Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments. Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin. Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartmen [...] "},{"id":"ENSMUSP00000108532","abundance":2.49,"rank":7753,"name":"Faim","annotation":"Fas apoptotic inhibitory molecule 1; Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells."},{"id":"ENSMUSP00000156049","abundance":2.49,"rank":7754,"name":"Pi4ka","annotation":"Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily."},{"id":"ENSMUSP00000143536","abundance":2.49,"rank":7755,"name":"Ulk1","annotation":"Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leadi [...] "},{"id":"ENSMUSP00000002084","abundance":2.49,"rank":7756,"name":"Abcd1","annotation":"ATP-binding cassette sub-family D member 1; Plays a role in the transport of free very-long-chain fatty acids (VLCFAs) as well as their CoA-esters across the peroxisomal membrane by acting as an ATP-specific binding subunit releasing ADP after ATP hydrolysis (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. Involved in several processes; namely, controls the active myelination phase by negatively regulating the micros [...] "},{"id":"ENSMUSP00000058355","abundance":2.49,"rank":7757,"name":"Polr1d","annotation":"DNA-directed RNA polymerases I and III subunit RPAC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively."},{"id":"ENSMUSP00000005053","abundance":2.48,"rank":7758,"name":"Tmem242","annotation":"Transmembrane protein 242; Belongs to the TMEM242 family."},{"id":"ENSMUSP00000037594","abundance":2.48,"rank":7759,"name":"4930480E11Rik","annotation":"RIKEN cDNA 4930480E11 gene."},{"id":"ENSMUSP00000127769","abundance":2.48,"rank":7760,"name":"C130050O18Rik","annotation":"RIKEN cDNA C130050O18 gene."},{"id":"ENSMUSP00000131158","abundance":2.48,"rank":7761,"name":"Hbp1","annotation":"HMG box-containing protein 1; Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'- TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity)."},{"id":"ENSMUSP00000044472","abundance":2.48,"rank":7762,"name":"Scaf4","annotation":"SR-related and CTD-associated factor 4; Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently  [...] "},{"id":"ENSMUSP00000054134","abundance":2.48,"rank":7763,"name":"Ldlrad3","annotation":"Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production."},{"id":"ENSMUSP00000039604","abundance":2.48,"rank":7764,"name":"Mul1","annotation":"Mitochondrial ubiquitin ligase activator of NFKB 1; Exhibits weak E3 ubiquitin-protein ligase activity (By similarity). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'- linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (By similarity). Proposed to preferentially act as a SUMO E3 ligase at phys [...] "},{"id":"ENSMUSP00000010974","abundance":2.48,"rank":7765,"name":"Kdelr3","annotation":"ER lumen protein-retaining receptor 3; Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum."},{"id":"ENSMUSP00000043540","abundance":2.48,"rank":7766,"name":"Krtcap2","annotation":"Keratinocyte-associated protein 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits  [...] "},{"id":"ENSMUSP00000032263","abundance":2.48,"rank":7767,"name":"Tmem52b","annotation":"Transmembrane protein 52B."},{"id":"ENSMUSP00000132193","abundance":2.48,"rank":7768,"name":"Smim26","annotation":"Small integral membrane protein 26."},{"id":"ENSMUSP00000134473","abundance":2.48,"rank":7769,"name":"Gm20509","annotation":"Predicted gene 20509."},{"id":"ENSMUSP00000035099","abundance":2.48,"rank":7770,"name":"Gorasp1","annotation":"Golgi reassembly-stacking protein 1; Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (By similarity). Mediates ER stress-induced unconventional (ER/Golgi- independent) trafficking of [...] "},{"id":"ENSMUSP00000099353","abundance":2.47,"rank":7771,"name":"Pitpnc1","annotation":"Cytoplasmic phosphatidylinositol transfer protein 1; Phosphatidylinositol transfer proteins mediate the monomeric transport of lipids by shielding a lipid from the aqueous environment and binding the lipid in a hydrophobic cavity. Able to transfer phosphatidylinositol in vitro. Isoform 2 specifically binds to phosphatidylinositol but not to other phospholipids and may play a role in the phosphoinositide-mediated signaling in the neural development."},{"id":"ENSMUSP00000070648","abundance":2.47,"rank":7772,"name":"Xkr4","annotation":"XK-related protein 4."},{"id":"ENSMUSP00000060124","abundance":2.47,"rank":7773,"name":"Spsb2","annotation":"SPRY domain-containing SOCS box protein 2; Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (By similarity)."},{"id":"ENSMUSP00000028220","abundance":2.47,"rank":7774,"name":"Fbxw2","annotation":"F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000105691","abundance":2.47,"rank":7775,"name":"Macrod2","annotation":"ADP-ribose glycohydrolase MACROD2; Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins."},{"id":"ENSMUSP00000095041","abundance":2.47,"rank":7776,"name":"Sytl3","annotation":"Synaptotagmin-like protein 3; May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions."},{"id":"ENSMUSP00000097648","abundance":2.47,"rank":7777,"name":"Samd5","annotation":"Sterile alpha motif domain-containing protein 5."},{"id":"ENSMUSP00000031456","abundance":2.47,"rank":7778,"name":"Pde6b","annotation":"Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme."},{"id":"ENSMUSP00000031029","abundance":2.47,"rank":7779,"name":"Snx17","annotation":"Sorting nexin-17; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity). Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (Ptd [...] "},{"id":"ENSMUSP00000069087","abundance":2.47,"rank":7780,"name":"Lamb2","annotation":"Laminin subunit beta-2; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."},{"id":"ENSMUSP00000027748","abundance":2.47,"rank":7781,"name":"Rgs16","annotation":"Regulator of G-protein signaling 16; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Plays an important role in the phototransduction cascade by regulating the lifetime and effective concentration of activated transducin alpha. May regulate extra and intracellular mitogenic signals."},{"id":"ENSMUSP00000042796","abundance":2.47,"rank":7782,"name":"Eri3","annotation":"ERI1 exoribonuclease 3."},{"id":"ENSMUSP00000069013","abundance":2.47,"rank":7783,"name":"Fank1","annotation":"Fibronectin type 3 and ankyrin repeat domains 1 protein; Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis."},{"id":"ENSMUSP00000020012","abundance":2.47,"rank":7784,"name":"Qrsl1","annotation":"Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily."},{"id":"ENSMUSP00000099468","abundance":2.47,"rank":7785,"name":"Mtmr4","annotation":"Myotubularin-related protein 4; Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para- nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5- trisphosphate (PIP3) (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily."},{"id":"ENSMUSP00000069681","abundance":2.47,"rank":7786,"name":"Fgf7","annotation":"Fibroblast growth factor 7; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation (By similarity)."},{"id":"ENSMUSP00000042959","abundance":2.47,"rank":7787,"name":"Fcho2","annotation":"F-BAR domain only protein 2; Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2- dependen [...] "},{"id":"ENSMUSP00000020668","abundance":2.47,"rank":7788,"name":"Havcr2","annotation":"Hepatitis A virus cellular receptor 2 homolog; Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in  [...] "},{"id":"ENSMUSP00000130142","abundance":2.47,"rank":7789,"name":"Phc3","annotation":"Polyhomeotic-like protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity)."},{"id":"ENSMUSP00000027312","abundance":2.46,"rank":7790,"name":"Prim2","annotation":"DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase su [...] "},{"id":"ENSMUSP00000045332","abundance":2.46,"rank":7791,"name":"Itprid1","annotation":"Protein ITPRID1."},{"id":"ENSMUSP00000112640","abundance":2.46,"rank":7792,"name":"Naf1","annotation":"H/ACA ribonucleoprotein complex non-core subunit NAF1; RNA-binding protein required for the maturation of box H/ACA snoRNPs complex and ribosome biogenesis. During assembly of the H/ACA snoRNPs complex, it associates with the complex and disappears during maturation of the complex and is replaced by NOLA1/GAR1 to yield mature H/ACA snoRNPs complex. Probably competes with NOLA1/GAR1 for binding with DKC1/NOLA4 (By similarity)."},{"id":"ENSMUSP00000029358","abundance":2.46,"rank":7793,"name":"Nmd3","annotation":"60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family."},{"id":"ENSMUSP00000027103","abundance":2.46,"rank":7794,"name":"Fastkd2","annotation":"FAST kinase domain-containing protein 2, mitochondrial; Plays an important role in assembly of the mitochondrial large ribosomal subunit. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation."},{"id":"ENSMUSP00000065845","abundance":2.46,"rank":7795,"name":"Cggbp1","annotation":"CGG triplet repeat-binding protein 1; Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats in the FMR1 promoter. May play a role in regulating FMR1 promoter (By similarity)."},{"id":"ENSMUSP00000151227","abundance":2.46,"rank":7796,"name":"Arid5b","annotation":"AT-rich interactive domain-containing protein 5B; Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulate [...] "},{"id":"ENSMUSP00000008004","abundance":2.46,"rank":7797,"name":"Ddx49","annotation":"Probable ATP-dependent RNA helicase DDX49."},{"id":"ENSMUSP00000073171","abundance":2.45,"rank":7798,"name":"Cryzl1","annotation":"Quinone oxidoreductase-like protein 1."},{"id":"ENSMUSP00000124067","abundance":2.45,"rank":7799,"name":"B3gat1","annotation":"Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo- fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl- sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regar [...] "},{"id":"ENSMUSP00000108960","abundance":2.45,"rank":7800,"name":"Ciz1","annotation":"CDKN1A-interacting zinc finger protein 1."},{"id":"ENSMUSP00000032988","abundance":2.45,"rank":7801,"name":"Prss8","annotation":"Prostasin heavy chain; Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates (By similarity). Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G); Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000120632","abundance":2.45,"rank":7802,"name":"Ppat","annotation":"Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family."},{"id":"ENSMUSP00000133045","abundance":2.45,"rank":7803,"name":"Lin52","annotation":"Protein lin-52 homolog."},{"id":"ENSMUSP00000022660","abundance":2.45,"rank":7804,"name":"Loxl2","annotation":"Lysyl oxidase homolog 2; Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (By similarity). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (By similarity). Also media [...] "},{"id":"ENSMUSP00000043901","abundance":2.45,"rank":7805,"name":"Mcrs1","annotation":"Microspherule protein 1; Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. Binds to G-quadruplex structures in mRNA. Binds to RNA homopolymer poly(G) and poly(U)."},{"id":"ENSMUSP00000104024","abundance":2.45,"rank":7806,"name":"Nlrp9a","annotation":"NACHT, LRR and PYD domains-containing protein 9A; May be involved in inflammation; Belongs to the NLRP family."},{"id":"ENSMUSP00000087269","abundance":2.45,"rank":7807,"name":"Gmnc","annotation":"Geminin coiled-coil domain-containing protein 1; Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity). Belongs to the GEMC1 family."},{"id":"ENSMUSP00000113881","abundance":2.45,"rank":7808,"name":"Ankef1","annotation":"Ankyrin repeat and EF-hand domain-containing protein 1."},{"id":"ENSMUSP00000097600","abundance":2.45,"rank":7809,"name":"Mb21d2","annotation":"Protein MB21D2; Belongs to the mab-21 family."},{"id":"ENSMUSP00000114123","abundance":2.44,"rank":7810,"name":"Erbb4","annotation":"Receptor tyrosine-protein kinase erbB-4; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins and EGF family members and regulates development of the heart, the central nervous system and the mammary gland, gene transcription, cell proliferation, differentiation, migration and apoptosis. Required for normal cardiac muscle differentiation during embryonic development, and for postnatal cardiomyocyte proliferation. Required for normal development of the embryonic central nervous system, especially for normal neural crest cell migration and normal  [...] "},{"id":"ENSMUSP00000022591","abundance":2.44,"rank":7811,"name":"Epsti1","annotation":"Epithelial-stromal interaction protein 1; Plays a role in M1 macrophage polarization and is required for the proper regulation of gene expression during M1 versus M2 macrophage differentiation. Might play a role in RELA/p65 and STAT1 phosphorylation and nuclear localization upon activation of macrophages."},{"id":"ENSMUSP00000094916","abundance":2.44,"rank":7812,"name":"Foxp4","annotation":"Forkhead box protein P4; Transcriptional repressor that represses lung-specific expression."},{"id":"ENSMUSP00000141087","abundance":2.44,"rank":7813,"name":"Gm28778","annotation":"Predicted gene 28778."},{"id":"ENSMUSP00000073325","abundance":2.44,"rank":7814,"name":"Oog4","annotation":"Oog4 protein."},{"id":"ENSMUSP00000077831","abundance":2.44,"rank":7815,"name":"Xlr4a","annotation":"X-linked lymphocyte-regulated 4A."},{"id":"ENSMUSP00000158415","abundance":2.44,"rank":7816,"name":"Gm50367","annotation":"Predicted gene, 50367."},{"id":"ENSMUSP00000116285","abundance":2.44,"rank":7817,"name":"Entpd1","annotation":"Ectonucleoside triphosphate diphosphohydrolase 1; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well."},{"id":"ENSMUSP00000034296","abundance":2.44,"rank":7818,"name":"Pik3r2","annotation":"Phosphatidylinositol 3-kinase regulatory subunit beta; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein- tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating t [...] "},{"id":"ENSMUSP00000094084","abundance":2.43,"rank":7819,"name":"Ncf4","annotation":"Neutrophil cytosol factor 4; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex."},{"id":"ENSMUSP00000104855","abundance":2.43,"rank":7820,"name":"Med7","annotation":"Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000031143","abundance":2.43,"rank":7821,"name":"Srd5a3","annotation":"Polyprenol reductase; Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N- glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5- alpha-dihydrotestosterone (DHT)."},{"id":"ENSMUSP00000073392","abundance":2.43,"rank":7822,"name":"Klk1b24","annotation":"Kallikrein 1-related peptidase b24; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000076208","abundance":2.43,"rank":7823,"name":"Ttf2","annotation":"Transcription termination factor 2; DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing (By similarity)."},{"id":"ENSMUSP00000077422","abundance":2.43,"rank":7824,"name":"Lyg2","annotation":"Lysozyme g-like protein 2; May act as a potent antibacterial protein that may play a role in the innate immunity; Belongs to the glycosyl hydrolase 23 family."},{"id":"ENSMUSP00000134642","abundance":2.43,"rank":7825,"name":"Vax1","annotation":"Ventral anterior homeobox 1; Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk; Belongs to the EMX homeobox family."},{"id":"ENSMUSP00000111219","abundance":2.43,"rank":7826,"name":"Zfp846","annotation":"Zinc finger protein 846."},{"id":"ENSMUSP00000077168","abundance":2.43,"rank":7827,"name":"Glmn","annotation":"Glomulin; Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F- box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to the RING domain of RBX1 and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1 (By similarity). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels. Essential for normal develop [...] "},{"id":"ENSMUSP00000104727","abundance":2.43,"rank":7828,"name":"Atmin","annotation":"ATM interactor; Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM (By similarity). Binds to the DYNLL1 promoter and activates its transcription."},{"id":"ENSMUSP00000023352","abundance":2.43,"rank":7829,"name":"Prkdc","annotation":"DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage (By similarity). Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity). Must be bound to DNA to express its catalytic properties (By similarity). Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C) (By similarity). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step  [...] "},{"id":"ENSMUSP00000035065","abundance":2.43,"rank":7830,"name":"Ptgs2","annotation":"Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] "},{"id":"ENSMUSP00000125387","abundance":2.43,"rank":7831,"name":"Maf1","annotation":"Repressor of RNA polymerase III transcription MAF1 homolog; Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity). Plays also a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation. Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made  [...] "},{"id":"ENSMUSP00000015771","abundance":2.42,"rank":7832,"name":"Gata5","annotation":"Transcription factor GATA-5; Transcription factor required during cardiovascular development (By similarity). Plays an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer (By similarity)."},{"id":"ENSMUSP00000061167","abundance":2.42,"rank":7833,"name":"Rps19bp1","annotation":"Active regulator of SIRT1; Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity)."},{"id":"ENSMUSP00000120240","abundance":2.42,"rank":7834,"name":"Wipf3","annotation":"WAS/WASL-interacting protein family member 3; May be a regulator of cytoskeletal organization (Potential). May have a role in spermatogenesis."},{"id":"ENSMUSP00000145069","abundance":2.42,"rank":7835,"name":"Emp1","annotation":"Epithelial membrane protein 1."},{"id":"ENSMUSP00000152794","abundance":2.42,"rank":7836,"name":"Gm49366","annotation":"Predicted gene, 49366."},{"id":"ENSMUSP00000141721","abundance":2.42,"rank":7837,"name":"Spata45","annotation":"Spermatogenesis-associated protein 45; Belongs to the SPATA45 family."},{"id":"ENSMUSP00000065585","abundance":2.42,"rank":7838,"name":"Cyp3a25","annotation":"Cytochrome P450 3A25; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics."},{"id":"ENSMUSP00000026217","abundance":2.42,"rank":7839,"name":"Chuk","annotation":"Inhibitor of nuclear factor kappa-B kinase subunit alpha; Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into t [...] "},{"id":"ENSMUSP00000035106","abundance":2.42,"rank":7840,"name":"Slc25a38","annotation":"Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily."},{"id":"ENSMUSP00000006123","abundance":2.42,"rank":7841,"name":"Tuft1","annotation":"Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family."},{"id":"ENSMUSP00000034697","abundance":2.42,"rank":7842,"name":"Slc44a2","annotation":"Choline transporter-like protein 2; Choline transporter; Belongs to the CTL (choline transporter-like) family."},{"id":"ENSMUSP00000070355","abundance":2.42,"rank":7843,"name":"Cdk17","annotation":"Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity)."},{"id":"ENSMUSP00000043826","abundance":2.42,"rank":7844,"name":"Pnpla3","annotation":"1-acylglycerol-3-phosphate O-acyltransferase Pnpla3; Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA. Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase  [...] "},{"id":"ENSMUSP00000106021","abundance":2.41,"rank":7845,"name":"Cmah","annotation":"Cytidine monophosphate-N-acetylneuraminic acid hydroxylase; Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell- pathogen interactions. Catalyzes the conversion of CMP-N- acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells."},{"id":"ENSMUSP00000020580","abundance":2.41,"rank":7846,"name":"Polrmt","annotation":"DNA-directed RNA polymerase, mitochondrial; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand."},{"id":"ENSMUSP00000027933","abundance":2.41,"rank":7847,"name":"Dtl","annotation":"Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), FBH1, KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication lice [...] "},{"id":"ENSMUSP00000026220","abundance":2.41,"rank":7848,"name":"Scd3","annotation":"Acyl-CoA desaturase 3; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA. Has a strong preference for saturated fatty acids with chain lengths of 14 or 16 carbon atoms (C14:0 and C16:0), and has only very low activity with stearatate (C18:0). Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)."},{"id":"ENSMUSP00000026036","abundance":2.41,"rank":7849,"name":"Nr0b1","annotation":"Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity)."},{"id":"ENSMUSP00000029771","abundance":2.41,"rank":7850,"name":"F3","annotation":"Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade."},{"id":"ENSMUSP00000100923","abundance":2.41,"rank":7851,"name":"Kera","annotation":"Keratocan; May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily."},{"id":"ENSMUSP00000153622","abundance":2.41,"rank":7852,"name":"Dnmt3c","annotation":"DNA (cytosine-5)-methyltransferase 3C; DNA methyltransferase that specifically methylates the promoters of evolutionarily young retrotransposons in the male germline. De novo methylation and subsequent repression of transposable elements prevents their mobilization, which is essential for germline integrity. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family."},{"id":"ENSMUSP00000026659","abundance":2.41,"rank":7853,"name":"Tmc6","annotation":"Transmembrane channel-like protein 6; Probable ion channel."},{"id":"ENSMUSP00000098043","abundance":2.41,"rank":7854,"name":"Gm11567","annotation":"Predicted gene 11567."},{"id":"ENSMUSP00000047951","abundance":2.41,"rank":7855,"name":"Foxn4","annotation":"Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'- ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 pro [...] "},{"id":"ENSMUSP00000106118","abundance":2.4,"rank":7856,"name":"Prag1","annotation":"Inactive tyrosine-protein kinase PRAG1; Catalytically inactive protein kinase that acts as a scaffold protein (By similarity). Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth (By similarity). Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism (By similarity). Acts as a critical coactivator of Notch signaling."},{"id":"ENSMUSP00000078148","abundance":2.4,"rank":7857,"name":"Ttc8","annotation":"Tetratricopeptide repeat protein 8; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl [...] "},{"id":"ENSMUSP00000042558","abundance":2.4,"rank":7858,"name":"Klhl42","annotation":"Kelch-like protein 42; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. Involved in microtubule dynamics throughout mitosis (By similarity)."},{"id":"ENSMUSP00000045552","abundance":2.4,"rank":7859,"name":"Ints9","annotation":"Integrator complex subunit 9; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex."},{"id":"ENSMUSP00000140596","abundance":2.4,"rank":7860,"name":"Fat1","annotation":"FAT atypical cadherin 1."},{"id":"ENSMUSP00000087636","abundance":2.4,"rank":7861,"name":"Zfyve19","annotation":"Abscission/NoCut checkpoint regulator; Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission [...] "},{"id":"ENSMUSP00000029649","abundance":2.4,"rank":7862,"name":"Ctso","annotation":"Cathepsin O; Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover."},{"id":"ENSMUSP00000127452","abundance":2.4,"rank":7863,"name":"Gm20721","annotation":"Predicted gene, 20721."},{"id":"ENSMUSP00000064926","abundance":2.4,"rank":7864,"name":"Gid4","annotation":"Glucose-induced degradation protein 4 homolog; Substrate-recognition subunit of the CTLH E3 ubiquitin- protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Binds proteins and peptides with a Pro/N-degron consisting of an unmodified N-terminal Pro followed by a small residue, and has the highest affinity for the peptide Pro-Gly- Leu-Trp. Binds peptides with an N-terminal sequence of the type Pro- [Ala,Gly]-[Leu,Met,Gln,Ser,Tyr]-[Glu,Gly,His,Ser,Val,Trp,Tyr]. Does not bind [...] "},{"id":"ENSMUSP00000105539","abundance":2.4,"rank":7865,"name":"Nr3c2","annotation":"Mineralocorticoid receptor; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels; Belongs to the nuclear hormone receptor family. NR3 subfamily."},{"id":"ENSMUSP00000032667","abundance":2.4,"rank":7866,"name":"Siglece","annotation":"Sialic acid-binding Ig-like lectin 12; Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules."},{"id":"ENSMUSP00000043315","abundance":2.4,"rank":7867,"name":"Wdr74","annotation":"WD repeat-containing protein 74; Regulatory protein of the MTREX-exosome complex involved in the synthesis of the 60S ribosomal subunit. Participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL (By similarity). Required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development."},{"id":"ENSMUSP00000025675","abundance":2.4,"rank":7868,"name":"Naa40","annotation":"N-alpha-acetyltransferase 40; N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (By similarity). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (By similarity). Acts as a negative regulator of apoptosis (By similarity). May play a role in hepatic lipid metabolism. Belongs to the acetyltransferase family. NAA40 subfamily."},{"id":"ENSMUSP00000068309","abundance":2.4,"rank":7869,"name":"Trmt1l","annotation":"TRMT1-like protein; May play a role in motor coordination and exploratory behavior; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family."},{"id":"ENSMUSP00000094085","abundance":2.4,"rank":7870,"name":"Apol7e","annotation":"Apolipoprotein L 7e."},{"id":"ENSMUSP00000128897","abundance":2.39,"rank":7871,"name":"Dlk2","annotation":"Protein delta homolog 2; Regulates adipogenesis."},{"id":"ENSMUSP00000077380","abundance":2.39,"rank":7872,"name":"Nsl1","annotation":"Kinetochore-associated protein NSL1 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis."},{"id":"ENSMUSP00000157851","abundance":2.39,"rank":7873,"name":"Slc14a2","annotation":"Urea transporter 2; Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Vasopressin regulates urea transport by increasing isoform A1 accumulation in the plasma membrane and/or phosphorylation of isoform A1 (By similarity)."},{"id":"ENSMUSP00000088322","abundance":2.39,"rank":7874,"name":"Sp9","annotation":"Transcription factor Sp9; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos."},{"id":"ENSMUSP00000150232","abundance":2.39,"rank":7875,"name":"Olfr545","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000031170","abundance":2.39,"rank":7876,"name":"Cenpc1","annotation":"Centromere protein C; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions."},{"id":"ENSMUSP00000054053","abundance":2.39,"rank":7877,"name":"Pfn3","annotation":"Profilin-3; Binds to actin and affects the structure of the cytoskeleton. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). Slightly reduces actin polymerization. May be involved in spermatogenesis."},{"id":"ENSMUSP00000034159","abundance":2.39,"rank":7878,"name":"Txnl4b","annotation":"Thioredoxin-like protein 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition (By similarity)."},{"id":"ENSMUSP00000026972","abundance":2.39,"rank":7879,"name":"Fam20c","annotation":"Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (By similarity). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (By similarity). Phosphorylates casein as well as a number of proteins involved in biomineralization such  [...] "},{"id":"ENSMUSP00000065397","abundance":2.39,"rank":7880,"name":"Tceal5","annotation":"Transcription elongation factor A protein-like 5; May be involved in transcriptional regulation; Belongs to the TFS-II family. TFA subfamily."},{"id":"ENSMUSP00000092901","abundance":2.39,"rank":7881,"name":"Jund","annotation":"Transcription factor jun-D; Transcription factor binding AP-1 sites."},{"id":"ENSMUSP00000058040","abundance":2.39,"rank":7882,"name":"Sstr3","annotation":"Somatostatin receptor type 3; Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase."},{"id":"ENSMUSP00000056162","abundance":2.39,"rank":7883,"name":"Krtap4-2","annotation":"Keratin-associated protein 4-2."},{"id":"ENSMUSP00000107614","abundance":2.39,"rank":7884,"name":"Hoxd3","annotation":"Homeobox protein Hox-D3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family."},{"id":"ENSMUSP00000003677","abundance":2.39,"rank":7885,"name":"Rnf215","annotation":"RING finger protein 215."},{"id":"ENSMUSP00000045349","abundance":2.39,"rank":7886,"name":"Chst11","annotation":"Carbohydrate sulfotransferase 11; Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor."},{"id":"ENSMUSP00000031367","abundance":2.39,"rank":7887,"name":"Slc15a4","annotation":"Solute carrier family 15 member 4; Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides (By similarity); Belongs to the PTR2/POT transporter (TC 2.A.17) family."},{"id":"ENSMUSP00000099320","abundance":2.39,"rank":7888,"name":"Fbf1","annotation":"Fas-binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis (By similarity)."},{"id":"ENSMUSP00000027249","abundance":2.39,"rank":7889,"name":"Chst10","annotation":"Carbohydrate sulfotransferase 10; Catalyzes the transfer of sulfate to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis; Belongs to the sulfotransferase 2 family."},{"id":"ENSMUSP00000082582","abundance":2.39,"rank":7890,"name":"Klk1b21","annotation":"Kallikrein 1-related peptidase b21; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Displays trypsin-like substrate specificity and shows activity towards casein, gelatin, fibronectin and IGFBP3; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000020643","abundance":2.38,"rank":7891,"name":"Rufy1","annotation":"RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking."},{"id":"ENSMUSP00000102342","abundance":2.38,"rank":7892,"name":"Lrp8","annotation":"Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brai [...] "},{"id":"ENSMUSP00000037025","abundance":2.38,"rank":7893,"name":"Pde4a","annotation":"cAMP-specific 3',5'-cyclic phosphodiesterase 4A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily."},{"id":"ENSMUSP00000033154","abundance":2.38,"rank":7894,"name":"Plk1","annotation":"Serine/threonine-protein kinase PLK1; Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase- promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, C [...] "},{"id":"ENSMUSP00000118809","abundance":2.38,"rank":7895,"name":"Zfp563","annotation":"Zinc finger protein 563."},{"id":"ENSMUSP00000137430","abundance":2.38,"rank":7896,"name":"Usp34","annotation":"Ubiquitin carboxyl-terminal hydrolase 34; Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precurs [...] "},{"id":"ENSMUSP00000014922","abundance":2.38,"rank":7897,"name":"Fhod1","annotation":"FH1/FH2 domain-containing protein 1; Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing (By similarity); Belongs to the formin homology family."},{"id":"ENSMUSP00000085325","abundance":2.38,"rank":7898,"name":"Gtf3c2","annotation":"General transcription factor 3C polypeptide 2; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 (By similarity)."},{"id":"ENSMUSP00000135220","abundance":2.38,"rank":7899,"name":"Taf6l","annotation":"TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity). With TAF5L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state [...] "},{"id":"ENSMUSP00000034945","abundance":2.38,"rank":7900,"name":"Ciao2a","annotation":"Cytosolic iron-sulfur assembly component 2A; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 specifically matures ACO1 and stabilizes IREB2. May play a role in chromosome segregation through establishment of sister chromatid cohesion. May induce apoptosis in collaboration with APAF1 ; Belongs to the MIP18 family."},{"id":"ENSMUSP00000018478","abundance":2.38,"rank":7901,"name":"Ksr1","annotation":"Kinase suppressor of Ras 1; Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (By similarity). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detecte [...] "},{"id":"ENSMUSP00000044630","abundance":2.38,"rank":7902,"name":"Lad1","annotation":"Ladinin-1; Anchoring filament protein which is a component of the basement membrane zone."},{"id":"ENSMUSP00000054084","abundance":2.37,"rank":7903,"name":"Heatr1","annotation":"HEAT repeat-containing 1."},{"id":"ENSMUSP00000135858","abundance":2.37,"rank":7904,"name":"Ryk","annotation":"Tyrosine-protein kinase RYK; May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development."},{"id":"ENSMUSP00000058896","abundance":2.37,"rank":7905,"name":"Ddit4l","annotation":"DNA damage-inducible transcript 4-like protein; Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Belongs to the DDIT4 family."},{"id":"ENSMUSP00000095011","abundance":2.37,"rank":7906,"name":"Gm3417","annotation":"Tctex1 domain-containing protein 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility."},{"id":"ENSMUSP00000025632","abundance":2.37,"rank":7907,"name":"Carnmt1","annotation":"Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His)."},{"id":"ENSMUSP00000109521","abundance":2.37,"rank":7908,"name":"Gtf3c5","annotation":"General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity); Belongs to the TFIIIC subunit 5 family."},{"id":"ENSMUSP00000022680","abundance":2.37,"rank":7909,"name":"Bin3","annotation":"Bridging integrator 3; Involved in cytokinesis and septation where it has a role in the localization of F-actin."},{"id":"ENSMUSP00000038877","abundance":2.37,"rank":7910,"name":"Pclaf","annotation":"PCNA-associated factor; PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork- blocking lesions. Also acts as a regulator of centrosome number (By similarity)."},{"id":"ENSMUSP00000042783","abundance":2.37,"rank":7911,"name":"Tmem135","annotation":"Transmembrane protein 135; Involved in mitochondrial metabolism by regulating the balance between mitochondrial fusion and fission. May act as a regulator of mitochondrial fission that promotes DNM1L- dependent fission through activation of DNM1L. May be involved in peroxisome organization (By similarity). Belongs to the TMEM135 family."},{"id":"ENSMUSP00000080162","abundance":2.37,"rank":7912,"name":"Adrb3","annotation":"Beta-3 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta- 3 is involved in the regulation of lipolysis and thermogenesis."},{"id":"ENSMUSP00000045948","abundance":2.37,"rank":7913,"name":"Noa1","annotation":"Nitric oxide-associated protein 1; Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP; Belongs to the TRAFAC class YlqF/YawG GTPase family. NOA1 subfamily."},{"id":"ENSMUSP00000026888","abundance":2.37,"rank":7914,"name":"Taf3","annotation":"Transcription initiation factor TFIID subunit 3; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. Belongs to the TAF3 family."},{"id":"ENSMUSP00000023510","abundance":2.37,"rank":7915,"name":"Umps","annotation":"Orotidine 5'-phosphate decarboxylase; In the C-terminal section; belongs to the OMP decarboxylase family."},{"id":"ENSMUSP00000039760","abundance":2.36,"rank":7916,"name":"Ypel1","annotation":"Protein yippee-like 1; May play a role in epithelioid conversion of fibroblasts."},{"id":"ENSMUSP00000018571","abundance":2.36,"rank":7917,"name":"Ypel2","annotation":"Protein yippee-like 2."},{"id":"ENSMUSP00000051990","abundance":2.36,"rank":7918,"name":"Nkx3-2","annotation":"Homeobox protein Nkx-3.2; Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus. Belongs to the NK-3 homeobox family."},{"id":"ENSMUSP00000016664","abundance":2.36,"rank":7919,"name":"Lnx2","annotation":"Ligand of Numb protein X 2."},{"id":"ENSMUSP00000070291","abundance":2.36,"rank":7920,"name":"4933402N03Rik","annotation":"RIKEN cDNA 4933402N03 gene."},{"id":"ENSMUSP00000024705","abundance":2.36,"rank":7921,"name":"Slc25a27","annotation":"Solute carrier family 25, member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000045089","abundance":2.36,"rank":7922,"name":"Mon1b","annotation":"Vacuolar fusion protein MON1 homolog B."},{"id":"ENSMUSP00000031322","abundance":2.36,"rank":7923,"name":"Cxcl15","annotation":"C-X-C motif chemokine 15; Chemotactic for neutrophils. Involved in lung-specific neutrophil trafficking during normal and inflammatory conditions."},{"id":"ENSMUSP00000024470","abundance":2.36,"rank":7924,"name":"Ogfod2","annotation":"2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2; Belongs to the OGFOD2 family."},{"id":"ENSMUSP00000154087","abundance":2.36,"rank":7925,"name":"Ppp6r2","annotation":"Serine/threonine-protein phosphatase 6 regulatory subunit 2; Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha; Belongs to the SAPS family."},{"id":"ENSMUSP00000113319","abundance":2.36,"rank":7926,"name":"Ccsap","annotation":"Centriole, cilia and spindle-associated protein; Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity)."},{"id":"ENSMUSP00000103526","abundance":2.35,"rank":7927,"name":"Dgke","annotation":"Diacylglycerol kinase epsilon; Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition (By similarity); Belongs to the eukaryotic diacylglycerol kinase family."},{"id":"ENSMUSP00000097150","abundance":2.35,"rank":7928,"name":"Mis18a","annotation":"Protein Mis18-alpha; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis."},{"id":"ENSMUSP00000057725","abundance":2.35,"rank":7929,"name":"Rtn4rl2","annotation":"Reticulon-4 receptor-like 2; Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Like other family members, plays a role in re [...] "},{"id":"ENSMUSP00000090277","abundance":2.35,"rank":7930,"name":"Pcgf1","annotation":"Polycomb group RING finger protein 1; Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell p [...] "},{"id":"ENSMUSP00000149988","abundance":2.35,"rank":7931,"name":"Olfr1487","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000075376","abundance":2.35,"rank":7932,"name":"Pdzrn3","annotation":"E3 ubiquitin-protein ligase PDZRN3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation."},{"id":"ENSMUSP00000033827","abundance":2.35,"rank":7933,"name":"Grk1","annotation":"Rhodopsin kinase GRK1; Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor that initiates the phototransduction cascade. This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination. May play a role in the maintenance of the outer nuclear layer in the retina ; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily."},{"id":"ENSMUSP00000145015","abundance":2.35,"rank":7934,"name":"BC049715","annotation":"Uncharacterized protein C12orf60 homolog."},{"id":"ENSMUSP00000146545","abundance":2.35,"rank":7935,"name":"Adam9","annotation":"Disintegrin and metalloproteinase domain-containing protein 9; Cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins."},{"id":"ENSMUSP00000034900","abundance":2.35,"rank":7936,"name":"Ooep","annotation":"Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions."},{"id":"ENSMUSP00000103057","abundance":2.35,"rank":7937,"name":"Gm11568","annotation":"Predicted gene 11568."},{"id":"ENSMUSP00000037354","abundance":2.35,"rank":7938,"name":"Upf3a","annotation":"UPF3 regulator of nonsense transcripts homolog A (Yeast)."},{"id":"ENSMUSP00000055763","abundance":2.35,"rank":7939,"name":"Rfesd","annotation":"Rieske domain-containing protein."},{"id":"ENSMUSP00000060732","abundance":2.35,"rank":7940,"name":"Lxn","annotation":"Latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation. Belongs to the protease inhibitor I47 (latexin) family."},{"id":"ENSMUSP00000063895","abundance":2.35,"rank":7941,"name":"Nanp","annotation":"N-acylneuraminate-9-phosphatase; Belongs to the HAD-like hydrolase superfamily. NANP family."},{"id":"ENSMUSP00000058264","abundance":2.35,"rank":7942,"name":"Myt1l","annotation":"Myelin transcription factor 1-like protein; Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and [...] "},{"id":"ENSMUSP00000045465","abundance":2.35,"rank":7943,"name":"Pnliprp1","annotation":"Inactive pancreatic lipase-related protein 1; May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity)."},{"id":"ENSMUSP00000100769","abundance":2.34,"rank":7944,"name":"H2al1n","annotation":"Histone H2A; Belongs to the histone H2A family."},{"id":"ENSMUSP00000104273","abundance":2.34,"rank":7945,"name":"Plscr3","annotation":"Phospholipid scramblase 3; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Seems to play a role in apoptosis, through translocation of cardiolipin from the inner to the outer mitochondrial membrane which promotes BID recruitment and enhances tBid-induced mit [...] "},{"id":"ENSMUSP00000023762","abundance":2.34,"rank":7946,"name":"Cers5","annotation":"Ceramide synthase 5; Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) as acyl donor. Can use other acyl donors, but with less efficiency."},{"id":"ENSMUSP00000054022","abundance":2.34,"rank":7947,"name":"Fbxo44","annotation":"F-box only protein 44; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000020855","abundance":2.34,"rank":7948,"name":"1700086D15Rik","annotation":"RIKEN cDNA 1700086D15 gene."},{"id":"ENSMUSP00000058572","abundance":2.34,"rank":7949,"name":"Ptprq","annotation":"Phosphatidylinositol phosphatase PTPRQ; Phosphatidylinositol phosphatase required for auditory function. May act by regulating the level of phosphatidylinositol 4,5- bisphosphate (PIP2) level in the basal region of hair bundles. Can dephosphorylate a broad range of phosphatidylinositol phosphates, including phosphatidylinositol 3,4,5-trisphosphate and most phosphatidylinositol monophosphates and diphosphates. Phosphate can be hydrolyzed from the D3 and D5 positions in the inositol ring. Has low tyrosine-protein phosphatase activity; however, the relevance of such activity in vivo is un [...] "},{"id":"ENSMUSP00000032710","abundance":2.34,"rank":7950,"name":"Slc17a6","annotation":"Vesicular glutamate transporter 2; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate."},{"id":"ENSMUSP00000031694","abundance":2.34,"rank":7951,"name":"Lmod2","annotation":"Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function."},{"id":"ENSMUSP00000031109","abundance":2.34,"rank":7952,"name":"Nsun7","annotation":"Putative methyltransferase NSUN7; May have S-adenosyl-L-methionine-dependent methyl-transferase activity."},{"id":"ENSMUSP00000034026","abundance":2.34,"rank":7953,"name":"Hpgd","annotation":"15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity)."},{"id":"ENSMUSP00000113827","abundance":2.34,"rank":7954,"name":"Cngb1","annotation":"Cyclic nucleotide-gated channel beta 1."},{"id":"ENSMUSP00000124710","abundance":2.34,"rank":7955,"name":"Mycbp2","annotation":"E3 ubiquitin-protein ligase MYCBP2; Atypical E3 ubiquitin-protein ligase which specifically mediates ubiquitination of threonine and serine residues on target proteins, instead of ubiquitinating lysine residues (By similarity). Shows esterification activity towards both threonine and serine, with a preference for threonine, and acts via two essential catalytic cysteine residues that relay ubiquitin to its substrate via thioester intermediates (By similarity). Interacts with the E2 enzymes UBE2D1, UBE2D3, UBE2E1 and UBE2L3 (By similarity). Plays a key role in neural development, probabl [...] "},{"id":"ENSMUSP00000105722","abundance":2.34,"rank":7956,"name":"Pde4c","annotation":"cAMP-specific 3',5'-cyclic phosphodiesterase 4C; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes; Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily."},{"id":"ENSMUSP00000116098","abundance":2.34,"rank":7957,"name":"Dhdds","annotation":"Dehydrodolichyl diphosphate synthase complex subunit Dhdds; With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stabilit [...] "},{"id":"ENSMUSP00000104529","abundance":2.33,"rank":7958,"name":"Mtg2","annotation":"Mitochondrial ribosome-associated GTPase 2."},{"id":"ENSMUSP00000034533","abundance":2.33,"rank":7959,"name":"Kcnj5","annotation":"G protein-activated inward rectifier potassium channel 4; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Belongs to the  [...] "},{"id":"ENSMUSP00000044979","abundance":2.33,"rank":7960,"name":"Cavin3","annotation":"Caveolae-associated protein 3; Regulates the traffic and/or budding of caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells (PubMed: 28285351,. Regulates the equilibrium between cell surface- associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expr [...] "},{"id":"ENSMUSP00000018989","abundance":2.33,"rank":7961,"name":"Unc45b","annotation":"Protein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development (By similarity)."},{"id":"ENSMUSP00000150883","abundance":2.33,"rank":7962,"name":"Olfr319","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000113715","abundance":2.33,"rank":7963,"name":"Vezt","annotation":"Vezatin; Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life. Required for morphogenesis of the preimplantation embryo, and for the implantation process."},{"id":"ENSMUSP00000085416","abundance":2.33,"rank":7964,"name":"Ncoa3","annotation":"Nuclear receptor coactivator 3; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Plays a central role in creating a multisubunit coactivator complex, probably via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interac [...] "},{"id":"ENSMUSP00000100779","abundance":2.33,"rank":7965,"name":"Ifna16","annotation":"Interferon alpha 16."},{"id":"ENSMUSP00000150798","abundance":2.33,"rank":7966,"name":"Olfr532","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000083707","abundance":2.33,"rank":7967,"name":"Cntn2","annotation":"Contactin-2; In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region; Belongs to the immunoglobulin superfamily. Contactin family."},{"id":"ENSMUSP00000099917","abundance":2.33,"rank":7968,"name":"Cstad","annotation":"CSA-conditional, T cell activation-dependent protein."},{"id":"ENSMUSP00000070759","abundance":2.33,"rank":7969,"name":"Sugct","annotation":"Succinate--hydroxymethylglutarate CoA-transferase; Catalyzes the succinyl-CoA-dependent conversion of glutarate to glutaryl-CoA. Can use different dicarboxylic acids as CoA acceptors, the preferred ones are glutarate, succinate, adipate, and 3- hydroxymethylglutarate (By similarity)."},{"id":"ENSMUSP00000140815","abundance":2.33,"rank":7970,"name":"Vgf","annotation":"Neuroendocrine regulatory peptide-1; [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain. [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous sy [...] "},{"id":"ENSMUSP00000013299","abundance":2.33,"rank":7971,"name":"Enkd1","annotation":"Enkurin domain-containing protein 1."},{"id":"ENSMUSP00000000939","abundance":2.33,"rank":7972,"name":"Hip1r","annotation":"Huntingtin-interacting protein 1-related protein; Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis."},{"id":"ENSMUSP00000111291","abundance":2.32,"rank":7973,"name":"Tango2","annotation":"Transport and Golgi organization 2 homolog."},{"id":"ENSMUSP00000124923","abundance":2.32,"rank":7974,"name":"Gm20671","annotation":"Predicted gene 20671."},{"id":"ENSMUSP00000078761","abundance":2.32,"rank":7975,"name":"Hsf2","annotation":"Heat shock factor protein 2; DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. HSF2 is expressed in a form that binds DNA constitutively but loses DNA binding by incubation at greater than 41 degrees C."},{"id":"ENSMUSP00000132117","abundance":2.32,"rank":7976,"name":"Wac","annotation":"WW domain-containing adapter protein with coiled-coil; Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription. Regulates the cell-cycle checkpoint activation in response to DNA damage. Positive regulator of amino acid starvation-induced autophagy. Also acts as a negative regulator of basal autophagy. Positively regulates MTOR activity by promot [...] "},{"id":"ENSMUSP00000080361","abundance":2.32,"rank":7977,"name":"Lypd11","annotation":"Ly6/PLAUR domain-containing 11."},{"id":"ENSMUSP00000026541","abundance":2.32,"rank":7978,"name":"Caly","annotation":"Neuron-specific vesicular protein calcyon; Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis."},{"id":"ENSMUSP00000092821","abundance":2.32,"rank":7979,"name":"Pdp2","annotation":"Pyruvate dehyrogenase phosphatase catalytic subunit 2."},{"id":"ENSMUSP00000093393","abundance":2.32,"rank":7980,"name":"Pdss2","annotation":"Decaprenyl-diphosphate synthase subunit 2; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. Belongs to the FPP/GGPP synthase family."},{"id":"ENSMUSP00000041210","abundance":2.32,"rank":7981,"name":"Eda2r","annotation":"Tumor necrosis factor receptor superfamily member 27; Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 (By similarity)."},{"id":"ENSMUSP00000071818","abundance":2.32,"rank":7982,"name":"Nol7","annotation":"Nucleolar protein 7."},{"id":"ENSMUSP00000036936","abundance":2.32,"rank":7983,"name":"Scd1","annotation":"Acyl-CoA desaturase 1; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the Delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation. Plays [...] "},{"id":"ENSMUSP00000121973","abundance":2.32,"rank":7984,"name":"Pgs1","annotation":"CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family."},{"id":"ENSMUSP00000021728","abundance":2.32,"rank":7985,"name":"Siva1","annotation":"Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity)."},{"id":"ENSMUSP00000029034","abundance":2.31,"rank":7986,"name":"Pmp2","annotation":"Myelin P2 protein; May play a role in lipid transport protein in Schwann cells. May bind cholesterol (By similarity)."},{"id":"ENSMUSP00000022460","abundance":2.31,"rank":7987,"name":"Galnt15","annotation":"Polypeptide N-acetylgalactosaminyltransferase 15; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate (By similarity)."},{"id":"ENSMUSP00000021609","abundance":2.31,"rank":7988,"name":"Golga5","annotation":"Golgin subfamily A member 5; Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport (By similarity)."},{"id":"ENSMUSP00000128056","abundance":2.31,"rank":7989,"name":"Ihh","annotation":"Indian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP)."},{"id":"ENSMUSP00000008016","abundance":2.31,"rank":7990,"name":"Id3","annotation":"DNA-binding protein inhibitor ID-3; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the [...] "},{"id":"ENSMUSP00000124039","abundance":2.31,"rank":7991,"name":"Osgep","annotation":"Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity; Belongs to the KAE1 / TsaD family."},{"id":"ENSMUSP00000021796","abundance":2.31,"rank":7992,"name":"Edn1","annotation":"Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family."},{"id":"ENSMUSP00000025847","abundance":2.31,"rank":7993,"name":"Fibp","annotation":"Acidic fibroblast growth factor intracellular-binding protein; May be involved in mitogenic function of FGF1 (By similarity). May mediate with IER2 FGF-signaling in the establishment of laterality in the embryo (By similarity)."},{"id":"ENSMUSP00000019950","abundance":2.31,"rank":7994,"name":"Ltv1","annotation":"Protein LTV1 homolog; Belongs to the LTV1 family."},{"id":"ENSMUSP00000059860","abundance":2.31,"rank":7995,"name":"Scd4","annotation":"Acyl-CoA desaturase 4; Stearyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. Required for the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (By similarity)."},{"id":"ENSMUSP00000150084","abundance":2.3,"rank":7996,"name":"Olfr870","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000092464","abundance":2.3,"rank":7997,"name":"Zfyve28","annotation":"Lateral signaling target protein 2 homolog; Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated (By similarity); Belongs to the lst-2 family."},{"id":"ENSMUSP00000033936","abundance":2.3,"rank":7998,"name":"Dkk4","annotation":"Dickkopf-related protein 4; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity); Belongs to the dickkopf family."},{"id":"ENSMUSP00000060463","abundance":2.3,"rank":7999,"name":"Shisal2a","annotation":"Protein shisa-like-2A."},{"id":"ENSMUSP00000031713","abundance":2.3,"rank":8000,"name":"Slc13a1","annotation":"Solute carrier family 13 member 1; Sodium/sulfate cotransporter that mediates sulfate reabsorption in the kidney; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily."},{"id":"ENSMUSP00000141268","abundance":2.3,"rank":8001,"name":"Mia3","annotation":"Transport and Golgi organization protein 1 homolog; Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein s [...] "},{"id":"ENSMUSP00000106945","abundance":2.3,"rank":8002,"name":"B4galt3","annotation":"Beta-1,4-galactosyltransferase 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the glycosyltransferase 7 family."},{"id":"ENSMUSP00000049342","abundance":2.3,"rank":8003,"name":"Upb1","annotation":"Beta-ureidopropionase; Catalyzes a late step in pyrimidine degradation. Converts N- carbamoyl-beta-alanine (3-ureidopropanoate) into beta-alanine, ammonia and carbon dioxide. Likewise, converts N-carbamoyl-beta- aminoisobutyrate (3-ureidoisobutyrate) into beta-aminoisobutyrate, ammonia and carbon dioxide; Belongs to the carbon-nitrogen hydrolase superfamily. BUP family."},{"id":"ENSMUSP00000075210","abundance":2.3,"rank":8004,"name":"Nsd2","annotation":"Histone-lysine N-methyltransferase NSD2; Histone methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity forming trimethylated 'Lys-27' (H3K27me3)."},{"id":"ENSMUSP00000026665","abundance":2.3,"rank":8005,"name":"Cbx4","annotation":"E3 SUMO-protein ligase CBX4; E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression."},{"id":"ENSMUSP00000129100","abundance":2.3,"rank":8006,"name":"Oplah","annotation":"5-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate."},{"id":"ENSMUSP00000001824","abundance":2.3,"rank":8007,"name":"Folh1","annotation":"Glutamate carboxypeptidase 2; Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate."},{"id":"ENSMUSP00000053913","abundance":2.29,"rank":8008,"name":"Lipk","annotation":"Lipase member K; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity)."},{"id":"ENSMUSP00000124696","abundance":2.29,"rank":8009,"name":"Setdb2","annotation":"Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere- associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity)."},{"id":"ENSMUSP00000113695","abundance":2.29,"rank":8010,"name":"Cbln2","annotation":"Cerebellin-2; Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for long- term maintenance but not establishment of excitatory synapses."},{"id":"ENSMUSP00000049156","abundance":2.29,"rank":8011,"name":"Ska1","annotation":"Spindle and kinetochore-associated protein 1; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a  [...] "},{"id":"ENSMUSP00000109660","abundance":2.29,"rank":8012,"name":"Gm14743","annotation":"Predicted gene 14743; Belongs to the calycin superfamily. Lipocalin family."},{"id":"ENSMUSP00000108634","abundance":2.29,"rank":8013,"name":"Rbm41","annotation":"RNA-binding protein 41; May bind RNA."},{"id":"ENSMUSP00000054837","abundance":2.29,"rank":8014,"name":"Gli2","annotation":"Zinc finger protein GLI2; Functions as transcription regulator in the hedgehog (Hh) pathway. Functions as transcriptional activator. May also function as transcriptional repressor. Requires STK36 for full transcriptional activator activity. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element (By similarity). Is involved in the smoothened (SHH) signaling pathway. Required for normal skeleton development. Belongs to the GLI C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000110662","abundance":2.29,"rank":8015,"name":"Ucma","annotation":"Unique cartilage matrix-associated protein C-terminal fragment; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Belongs to the UCMA family."},{"id":"ENSMUSP00000126243","abundance":2.29,"rank":8016,"name":"Tox2","annotation":"TOX high mobility group box family member 2."},{"id":"ENSMUSP00000020767","abundance":2.29,"rank":8017,"name":"Polm","annotation":"DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination."},{"id":"ENSMUSP00000101515","abundance":2.29,"rank":8018,"name":"LTO1","annotation":"Protein LTO1 homolog; The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. May play a role in the regulation of proline metabolism and ROS production."},{"id":"ENSMUSP00000111990","abundance":2.28,"rank":8019,"name":"Stk40","annotation":"Serine/threonine-protein kinase 40; May be a negative regulator of NF-kappa-B and p53-mediated gene transcription; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family."},{"id":"ENSMUSP00000069466","abundance":2.28,"rank":8020,"name":"Adam11","annotation":"Disintegrin and metalloproteinase domain-containing protein 11; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein."},{"id":"ENSMUSP00000083840","abundance":2.28,"rank":8021,"name":"Alk","annotation":"ALK tyrosine kinase receptor; Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen- activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as o [...] "},{"id":"ENSMUSP00000077067","abundance":2.28,"rank":8022,"name":"St5","annotation":"DENN domain-containing protein 2B; [Isoform 1]: May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane.  [Isoform 3]: May block ERK2 activation stimulated by ABL1. May alter cell morphology and cell growth."},{"id":"ENSMUSP00000022464","abundance":2.28,"rank":8023,"name":"Msmb","annotation":"Beta-microseminoprotein; Belongs to the beta-microseminoprotein family."},{"id":"ENSMUSP00000013338","abundance":2.28,"rank":8024,"name":"Arih2","annotation":"E3 ubiquitin-protein ligase ARIH2; E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (By similarity). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin- protein ligase acti [...] "},{"id":"ENSMUSP00000043816","abundance":2.28,"rank":8025,"name":"Col27a1","annotation":"Collagen alpha-1(XXVII) chain; Plays a role during the calcification of cartilage and the transition of cartilage to bone."},{"id":"ENSMUSP00000050862","abundance":2.28,"rank":8026,"name":"Tmem37","annotation":"Voltage-dependent calcium channel gamma-like subunit; Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). Modulates calcium current when coexpressed with CACNA1G."},{"id":"ENSMUSP00000041013","abundance":2.28,"rank":8027,"name":"Btn1a1","annotation":"Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family."},{"id":"ENSMUSP00000020679","abundance":2.28,"rank":8028,"name":"Nipal4","annotation":"Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (By similarity); Belongs to the NIPA family."},{"id":"ENSMUSP00000139572","abundance":2.28,"rank":8029,"name":"Ldhal6b","annotation":"L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily."},{"id":"ENSMUSP00000053483","abundance":2.28,"rank":8030,"name":"Hic1","annotation":"Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] "},{"id":"ENSMUSP00000010198","abundance":2.28,"rank":8031,"name":"Tusc2","annotation":"Tumor suppressor candidate 2."},{"id":"ENSMUSP00000027299","abundance":2.28,"rank":8032,"name":"Prss39","annotation":"Inactive serine protease 39; May play an important role in the sperm/egg interaction; released during the acrosome reaction; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000091541","abundance":2.28,"rank":8033,"name":"Abhd15","annotation":"Protein ABHD15."},{"id":"ENSMUSP00000112518","abundance":2.28,"rank":8034,"name":"Fbxl21","annotation":"F-box/LRR-repeat protein 21; Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock r [...] "},{"id":"ENSMUSP00000047718","abundance":2.28,"rank":8035,"name":"Ssh3","annotation":"Protein phosphatase Slingshot homolog 3; Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly."},{"id":"ENSMUSP00000033394","abundance":2.28,"rank":8036,"name":"Fadd","annotation":"FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity)."},{"id":"ENSMUSP00000154463","abundance":2.28,"rank":8037,"name":"Vmn1r26","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000066128","abundance":2.28,"rank":8038,"name":"Rnf181","annotation":"E3 ubiquitin-protein ligase RNF181; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Belongs to the RNF181 family."},{"id":"ENSMUSP00000044937","abundance":2.28,"rank":8039,"name":"Nars2","annotation":"Probable asparagine--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000005233","abundance":2.28,"rank":8040,"name":"Eif2ak4","annotation":"eIF-2-alpha kinase GCN2; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability. Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. Converts phosphorylated eIF-2- alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a transl [...] "},{"id":"ENSMUSP00000045803","abundance":2.27,"rank":8041,"name":"Ptpn7","annotation":"Tyrosine-protein phosphatase non-receptor type 7; May play a role in the regulation of T and B-lymphocyte development and signal transduction; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily."},{"id":"ENSMUSP00000113963","abundance":2.27,"rank":8042,"name":"D930020B18Rik","annotation":"Uncharacterized protein C12orf56 homolog."},{"id":"ENSMUSP00000068904","abundance":2.27,"rank":8043,"name":"Mok","annotation":"MAPK/MAK/MRK overlapping kinase; Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner."},{"id":"ENSMUSP00000149299","abundance":2.27,"rank":8044,"name":"Olfr1299","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000021166","abundance":2.27,"rank":8045,"name":"Cygb","annotation":"Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer; Belongs to the globin family."},{"id":"ENSMUSP00000005490","abundance":2.27,"rank":8046,"name":"Slc1a6","annotation":"Excitatory amino acid transporter 4; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synapt [...] "},{"id":"ENSMUSP00000026548","abundance":2.27,"rank":8047,"name":"Adgra1","annotation":"Adhesion G protein-coupled receptor A1; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily."},{"id":"ENSMUSP00000018113","abundance":2.27,"rank":8048,"name":"Ptgis","annotation":"Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000117928","abundance":2.27,"rank":8049,"name":"Pax9","annotation":"Paired box protein Pax-9; Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs."},{"id":"ENSMUSP00000124703","abundance":2.27,"rank":8050,"name":"Pheta2","annotation":"Sesquipedalian-2; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane."},{"id":"ENSMUSP00000062496","abundance":2.27,"rank":8051,"name":"Ccndbp1","annotation":"Cyclin-D1-binding protein 1; May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription (By similarity). May be required for hepatocyte proliferation; Belongs to the CCNDBP1 family."},{"id":"ENSMUSP00000084958","abundance":2.27,"rank":8052,"name":"Hmx1","annotation":"Homeobox protein HMX1; DNA-binding protein that binds to the 5'-CAAG-3' core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear. Belongs to the HMX homeobox family."},{"id":"ENSMUSP00000061634","abundance":2.27,"rank":8053,"name":"Trarg1","annotation":"Trafficking regulator of GLUT4 1; Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. Belongs to the CD225/Dispanin family."},{"id":"ENSMUSP00000041361","abundance":2.27,"rank":8054,"name":"Fhod3","annotation":"FH1/FH2 domain-containing protein 3; May play a role in actin filament polymerization in cardiomyocytes (By similarity). Actin-organizing protein that may cause stress fiber formation together with cell elongation; Belongs to the formin homology family."},{"id":"ENSMUSP00000032969","abundance":2.27,"rank":8055,"name":"Pold3","annotation":"DNA polymerase delta subunit 3; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (By similarity). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhi [...] "},{"id":"ENSMUSP00000092961","abundance":2.27,"rank":8056,"name":"1700029J07Rik","annotation":"UPF0602 protein C4orf47 homolog."},{"id":"ENSMUSP00000022064","abundance":2.26,"rank":8057,"name":"Lrrc14b","annotation":"Leucine-rich repeat-containing protein 14B; Belongs to the PRAME family. LRRC14 subfamily."},{"id":"ENSMUSP00000041944","abundance":2.26,"rank":8058,"name":"Zfp324","annotation":"Zinc finger protein 324."},{"id":"ENSMUSP00000018765","abundance":2.26,"rank":8059,"name":"Mmp8","annotation":"Neutrophil collagenase; Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution."},{"id":"ENSMUSP00000117392","abundance":2.26,"rank":8060,"name":"Zdhhc3","annotation":"Palmitoyltransferase ZDHHC3; Palmitoyltransferase with broad specificity. Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability. Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25."},{"id":"ENSMUSP00000098778","abundance":2.26,"rank":8061,"name":"Ripply1","annotation":"Protein ripply1; Plays a role in somitogenesis. Essential for transcriptional repression of the segmental patterning genes, thus terminating the segmentation program in the presomitic mesoderm, and also required for the maintenance of rostrocaudal polarity in somites (By similarity)."},{"id":"ENSMUSP00000033731","abundance":2.26,"rank":8062,"name":"Zfp275","annotation":"Zinc finger protein 275."},{"id":"ENSMUSP00000030336","abundance":2.26,"rank":8063,"name":"Tnfrsf1b","annotation":"Tumor necrosis factor receptor superfamily member 1B; Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity)."},{"id":"ENSMUSP00000121038","abundance":2.26,"rank":8064,"name":"Dnal1","annotation":"Dynein light chain 1, axonemal; Part of the multisubunit axonemal ATPase complexes that generate the force for cilia motility and govern beat frequency (By similarity). Component of the outer arm dynein (ODA). May be involved in a mechanosensory feedback mechanism controlling ODA activity based on external conformational cues by tethering the outer arm dynein heavy chain (DNAH5) to the microtubule within the axoneme (By similarity). Important for ciliary function in the airways and for the function of the cilia that produce the nodal flow essential for the determination of the left-rig [...] "},{"id":"ENSMUSP00000154996","abundance":2.26,"rank":8065,"name":"Gm49510","annotation":"Predicted gene, 49510."},{"id":"ENSMUSP00000101719","abundance":2.26,"rank":8066,"name":"Foxk2","annotation":"Forkhead box protein K2; Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate  [...] "},{"id":"ENSMUSP00000149536","abundance":2.26,"rank":8067,"name":"Olfr550","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000033139","abundance":2.26,"rank":8068,"name":"Ate1","annotation":"Arginyl-tRNA--protein transferase 1; Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues; Belongs to the R-transferase family."},{"id":"ENSMUSP00000034048","abundance":2.26,"rank":8069,"name":"Cfap97","annotation":"Cilia- and flagella-associated protein 97; Belongs to the CFAP97 family."},{"id":"ENSMUSP00000081044","abundance":2.25,"rank":8070,"name":"Htra4","annotation":"Serine protease HTRA4; Serine protease; Belongs to the peptidase S1C family."},{"id":"ENSMUSP00000102493","abundance":2.25,"rank":8071,"name":"Olfr630","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000025364","abundance":2.25,"rank":8072,"name":"Yipf5","annotation":"Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi; Belongs to the YIP1 family."},{"id":"ENSMUSP00000018005","abundance":2.25,"rank":8073,"name":"Mybl2","annotation":"Myb-related protein B; Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene (By similarity)."},{"id":"ENSMUSP00000004470","abundance":2.25,"rank":8074,"name":"Utp20","annotation":"Small subunit processome component 20 homolog; Involved in 18S pre-rRNA processing. Associates with U3 snoRNA (By similarity)."},{"id":"ENSMUSP00000109267","abundance":2.25,"rank":8075,"name":"Arhgap25","annotation":"Rho GTPase-activating protein 25; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state."},{"id":"ENSMUSP00000003599","abundance":2.25,"rank":8076,"name":"Pcdhgb6","annotation":"Protocadherin gamma subfamily B, 6."},{"id":"ENSMUSP00000090369","abundance":2.25,"rank":8077,"name":"Gm11563","annotation":"Predicted gene 11563."},{"id":"ENSMUSP00000148894","abundance":2.25,"rank":8078,"name":"Olfr907","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000071770","abundance":2.25,"rank":8079,"name":"Ano6","annotation":"Anoctamin-6; Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chlor [...] "},{"id":"ENSMUSP00000027675","abundance":2.25,"rank":8080,"name":"Pigr","annotation":"Polymeric immunoglobulin receptor; This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment (By similarity)."},{"id":"ENSMUSP00000110500","abundance":2.25,"rank":8081,"name":"Cstdc6","annotation":"Cystatin domain-containing 6."},{"id":"ENSMUSP00000105425","abundance":2.25,"rank":8082,"name":"Ccm2l","annotation":"Cerebral cavernous malformations 2 protein-like."},{"id":"ENSMUSP00000028623","abundance":2.25,"rank":8083,"name":"Ext2","annotation":"Exostosin-2; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Appears to be a tumor suppressor. Required for the exosomal release of SDCBP, CD63 and syndecan."},{"id":"ENSMUSP00000104519","abundance":2.25,"rank":8084,"name":"Cables2","annotation":"CDK5 and ABL1 enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition."},{"id":"ENSMUSP00000080030","abundance":2.24,"rank":8085,"name":"Serpinb12","annotation":"Serpin B12; Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator; Belongs to the serpin family. Ov-serpin subfamily."},{"id":"ENSMUSP00000044250","abundance":2.24,"rank":8086,"name":"Stpg4","annotation":"Protein STPG4; Maternal factor that plays a role in epigenetic chromatin reprogramming during early development of the zygote. Involved in the regulation of gametic DNA demethylation by inducing the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC)."},{"id":"ENSMUSP00000153678","abundance":2.24,"rank":8087,"name":"Rnf180","annotation":"E3 ubiquitin-protein ligase RNF180; E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2."},{"id":"ENSMUSP00000034822","abundance":2.24,"rank":8088,"name":"Acsbg1","annotation":"Long-chain-fatty-acid--CoA ligase ACSBG1; Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (By similarity). Can activate diverse saturated, monosaturated and polyunsaturated fatty acids."},{"id":"ENSMUSP00000073720","abundance":2.24,"rank":8089,"name":"Bmp4","annotation":"Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction."},{"id":"ENSMUSP00000079140","abundance":2.24,"rank":8090,"name":"Btnl1","annotation":"Butyrophilin-like protein 1."},{"id":"ENSMUSP00000039737","abundance":2.24,"rank":8091,"name":"Atp6v0a2","annotation":"V-type proton ATPase 116 kDa subunit a isoform 2; Part of the proton channel of V-ATPases (By similarity). Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity); Belongs to the V-ATPase 116 kDa subunit family."},{"id":"ENSMUSP00000107688","abundance":2.24,"rank":8092,"name":"Klrc2","annotation":"Killer cell lectin-like receptor subfamily C, member 2."},{"id":"ENSMUSP00000026461","abundance":2.24,"rank":8093,"name":"Prim1","annotation":"DNA primase small subunit; Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase sub [...] "},{"id":"ENSMUSP00000108629","abundance":2.24,"rank":8094,"name":"Cnot6l","annotation":"CCR4-NOT transcription complex subunit 6-like; Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the c [...] "},{"id":"ENSMUSP00000075825","abundance":2.24,"rank":8095,"name":"Pyroxd2","annotation":"Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2; Probable oxidoreductase."},{"id":"ENSMUSP00000072863","abundance":2.24,"rank":8096,"name":"Ppox","annotation":"Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX."},{"id":"ENSMUSP00000107053","abundance":2.24,"rank":8097,"name":"ENSMUSP00000107053","annotation":"Sp110 nuclear body protein-like."},{"id":"ENSMUSP00000077215","abundance":2.24,"rank":8098,"name":"Ipcef1","annotation":"Interactor protein for cytohesin exchange factors 1; Enhances the promotion of guanine-nucleotide exchange by PSCD2 on ARF6 in a concentration-dependent manner."},{"id":"ENSMUSP00000010038","abundance":2.24,"rank":8099,"name":"Snap47","annotation":"Synaptosomal-associated protein 47; May play a role in intracellular membrane fusion. Belongs to the SVAP1 family."},{"id":"ENSMUSP00000047926","abundance":2.24,"rank":8100,"name":"Srpx","annotation":"Sushi-repeat-containing protein SRPX."},{"id":"ENSMUSP00000074733","abundance":2.24,"rank":8101,"name":"Cyp4f13","annotation":"Cytochrome P450, family 4, subfamily f, polypeptide 13; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000132287","abundance":2.23,"rank":8102,"name":"Gtf2e2","annotation":"General transcription factor IIE subunit 2; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity). Belongs to the TFIIE beta subunit family."},{"id":"ENSMUSP00000095818","abundance":2.23,"rank":8103,"name":"Olfr568","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000064237","abundance":2.23,"rank":8104,"name":"Apol8","annotation":"Apolipoprotein L 8."},{"id":"ENSMUSP00000054909","abundance":2.23,"rank":8105,"name":"Txndc2","annotation":"Thioredoxin domain-containing protein 2; Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase."},{"id":"ENSMUSP00000110513","abundance":2.23,"rank":8106,"name":"Ilrun","annotation":"Protein ILRUN; Negative regulator of innate antiviral response. Blocks IRF3- dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP."},{"id":"ENSMUSP00000054054","abundance":2.23,"rank":8107,"name":"Neurog3","annotation":"Neurogenin-3; Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types."},{"id":"ENSMUSP00000080425","abundance":2.23,"rank":8108,"name":"Eya3","annotation":"Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. The phosphatase activity has been shown in v [...] "},{"id":"ENSMUSP00000028384","abundance":2.23,"rank":8109,"name":"Dusp19","annotation":"Dual specificity protein phosphatase 19; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000035458","abundance":2.23,"rank":8110,"name":"Abca6","annotation":"ATP-binding cassette sub-family A member 6; Probable transporter which may play a role in macrophage lipid homeostasis."},{"id":"ENSMUSP00000101914","abundance":2.23,"rank":8111,"name":"Hivep3","annotation":"Transcription factor HIVEP3; Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation pro [...] "},{"id":"ENSMUSP00000109633","abundance":2.23,"rank":8112,"name":"Dmd","annotation":"Dystrophin; Anchors the extracellular matrix to the cytoskeleton via F- actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission."},{"id":"ENSMUSP00000016231","abundance":2.23,"rank":8113,"name":"Fli1","annotation":"Friend leukemia integration 1 transcription factor; Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'; Belongs to the ETS family."},{"id":"ENSMUSP00000099709","abundance":2.23,"rank":8114,"name":"Trit1","annotation":"tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)."},{"id":"ENSMUSP00000055901","abundance":2.23,"rank":8115,"name":"Stx19","annotation":"Syntaxin-19; Plays a role in endosomal trafficking of the epidermal growth factor receptor (EGFR)."},{"id":"ENSMUSP00000149696","abundance":2.23,"rank":8116,"name":"Olfr1189","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000005829","abundance":2.23,"rank":8117,"name":"Ampd3","annotation":"AMP deaminase 3; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family."},{"id":"ENSMUSP00000119881","abundance":2.22,"rank":8118,"name":"Gm29094","annotation":"Predicted gene 29094."},{"id":"ENSMUSP00000029201","abundance":2.22,"rank":8119,"name":"Pik3ca","annotation":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to v [...] "},{"id":"ENSMUSP00000034230","abundance":2.22,"rank":8120,"name":"Cx3cl1","annotation":"Processed fractalkine; Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (By similarity). The soluble form is chemotactic for T-cells and monocytes, but not for neutrophil [...] "},{"id":"ENSMUSP00000053891","abundance":2.22,"rank":8121,"name":"Itga2","annotation":"Integrin alpha-2; Integrin alpha-2/beta-1 is a collagen receptor, being responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. It is also a receptor for laminins, collagen C-propeptides and E- cadherin. Mice homozygous for a null mutation in the alpha-2 die very early in embryogenesis."},{"id":"ENSMUSP00000126417","abundance":2.22,"rank":8122,"name":"Racgap1","annotation":"Rac GTPase-activating protein 1; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogene [...] "},{"id":"ENSMUSP00000113537","abundance":2.22,"rank":8123,"name":"Fam118b","annotation":"Protein FAM118B; May play a role in Cajal bodies formation."},{"id":"ENSMUSP00000061062","abundance":2.22,"rank":8124,"name":"Gprc5a","annotation":"Retinoic acid-induced protein 3; Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provides evidence for a possible interaction between retinoid and G-protein signaling pathways. Functions as a negative modulator of EGFR signaling. Acts as a lung tumor suppressor."},{"id":"ENSMUSP00000029179","abundance":2.22,"rank":8125,"name":"Tti1","annotation":"TELO2-interacting protein 1 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate [...] "},{"id":"ENSMUSP00000029448","abundance":2.22,"rank":8126,"name":"Sycp1","annotation":"Synaptonemal complex protein 1; Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility."},{"id":"ENSMUSP00000151168","abundance":2.22,"rank":8127,"name":"Olfr1349","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000010286","abundance":2.22,"rank":8128,"name":"Tnfrsf13b","annotation":"Tumor necrosis factor receptor superfamily member 13B; Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin- dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity (By similarity)."},{"id":"ENSMUSP00000149334","abundance":2.22,"rank":8129,"name":"Olfr122","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000029970","abundance":2.22,"rank":8130,"name":"Slc35a1","annotation":"CMP-sialic acid transporter; Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function. Efficient CMP-sialic acid uptake depends on the presence of free CMP inside the vesicles, suggesting the proteins functions as an antiporter. Binds both CMP- sialic acid and free CMP, but has higher affinity for free CMP ; Belongs to the nucleotide-sugar transporter family. SLC35A subfamily."},{"id":"ENSMUSP00000036890","abundance":2.22,"rank":8131,"name":"Pkp2","annotation":"Plakophilin 2."},{"id":"ENSMUSP00000062782","abundance":2.22,"rank":8132,"name":"Vav2","annotation":"Guanine nucleotide exchange factor VAV2; Guanine nucleotide exchange factor for the Rho family of Ras- related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly."},{"id":"ENSMUSP00000021177","abundance":2.21,"rank":8133,"name":"Sec14l1","annotation":"SEC14-like protein 1; May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation. May also regulate the SLC18A3 and SLC5A7 cholinergic transporters."},{"id":"ENSMUSP00000135483","abundance":2.21,"rank":8134,"name":"Tmem70","annotation":"Transmembrane protein 70, mitochondrial; Involved in biogenesis of mitochondrial ATP synthase. Belongs to the TMEM70 family."},{"id":"ENSMUSP00000027697","abundance":2.21,"rank":8135,"name":"Cdk18","annotation":"Cyclin-dependent kinase 18; May play a role in signal transduction cascades in terminally differentiated cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."},{"id":"ENSMUSP00000116327","abundance":2.21,"rank":8136,"name":"Tmub2","annotation":"Transmembrane and ubiquitin-like domain-containing protein 2."},{"id":"ENSMUSP00000153364","abundance":2.21,"rank":8137,"name":"Smc5","annotation":"Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity)."},{"id":"ENSMUSP00000029444","abundance":2.21,"rank":8138,"name":"Trim33","annotation":"E3 ubiquitin-protein ligase TRIM33; Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway (By similarity). May act as a transcriptional repressor (By similarity). Inhibits the transcriptional response to TGF-beta/BMP signaling cascade (By similarity). Plays a role in the control of cell proliferation (By similarity). Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/ [...] "},{"id":"ENSMUSP00000047962","abundance":2.21,"rank":8139,"name":"Alx4","annotation":"Homeobox protein aristaless-like 4; Transcription factor involved in skull and limb development; Belongs to the paired homeobox family."},{"id":"ENSMUSP00000136334","abundance":2.21,"rank":8140,"name":"Aldh3b3","annotation":"Aldehyde dehydrogenase family 3 member B3; Oxidizes medium and long chain aldehydes into non-toxic fatty acids."},{"id":"ENSMUSP00000041700","abundance":2.21,"rank":8141,"name":"Fbxl18","annotation":"F-box and leucine-rich repeat protein 18."},{"id":"ENSMUSP00000120516","abundance":2.21,"rank":8142,"name":"Msi1","annotation":"RNA-binding protein Musashi homolog 1; RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU- 3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system."},{"id":"ENSMUSP00000054412","abundance":2.2,"rank":8143,"name":"Dnd1","annotation":"Dead end protein homolog 1; RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression (By similarity). Relieves miRNA repression in germline cells (By similarity). Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds specifically to U-rich regions (URRs) in the 3' untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Isoform 1 may play a role during primordial germ cell (PGC) survival. Howe [...] "},{"id":"ENSMUSP00000137203","abundance":2.2,"rank":8144,"name":"Sox1","annotation":"Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity)."},{"id":"ENSMUSP00000100503","abundance":2.2,"rank":8145,"name":"Ranbp6","annotation":"Ran-binding protein 6; May function in nuclear protein import as nuclear transport receptor; Belongs to the importin beta family."},{"id":"ENSMUSP00000001497","abundance":2.2,"rank":8146,"name":"Cideb","annotation":"Cell death activator CIDE-B; Activates apoptosis."},{"id":"ENSMUSP00000101978","abundance":2.2,"rank":8147,"name":"Mettl23","annotation":"Methyltransferase-like protein 23; Probable methyltransferase."},{"id":"ENSMUSP00000060791","abundance":2.2,"rank":8148,"name":"Hilpda","annotation":"Hypoxia-inducible lipid droplet-associated protein; Increases intracellular lipid accumulation. Stimulates expression of cytokines including IL6, MIF and VEGFA. Enhances cell growth and proliferation (By similarity)."},{"id":"ENSMUSP00000029071","abundance":2.2,"rank":8149,"name":"Car13","annotation":"Carbonic anhydrase 13; Reversible hydration of carbon dioxide."},{"id":"ENSMUSP00000108191","abundance":2.2,"rank":8150,"name":"Kctd12b","annotation":"Potassium channel tetramerisation domain-containing 12b."},{"id":"ENSMUSP00000108225","abundance":2.2,"rank":8151,"name":"Dpp10","annotation":"Inactive dipeptidyl peptidase 10; Promotes cell surface expression of the potassium channel KCND2. Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity (Probable)."},{"id":"ENSMUSP00000130306","abundance":2.2,"rank":8152,"name":"Spata2l","annotation":"Spermatogenesis-associated protein 2-like protein."},{"id":"ENSMUSP00000156387","abundance":2.2,"rank":8153,"name":"Mapk13","annotation":"Mitogen-activated protein kinase 13; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studie [...] "},{"id":"ENSMUSP00000056586","abundance":2.2,"rank":8154,"name":"Psg23","annotation":"Pregnancy-specific glycoprotein 23."},{"id":"ENSMUSP00000019662","abundance":2.2,"rank":8155,"name":"Ap4m1","annotation":"AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells and [...] "},{"id":"ENSMUSP00000024698","abundance":2.2,"rank":8156,"name":"Tnfrsf12a","annotation":"Tumor necrosis factor receptor superfamily member 12A; Receptor for TNFSF12/TWEAK (By similarity). Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins."},{"id":"ENSMUSP00000087405","abundance":2.2,"rank":8157,"name":"Gch1","annotation":"GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence."},{"id":"ENSMUSP00000092389","abundance":2.2,"rank":8158,"name":"Psg25","annotation":"Pregnancy-specific glycoprotein 25."},{"id":"ENSMUSP00000121803","abundance":2.2,"rank":8159,"name":"Inpp4a","annotation":"Inositol polyphosphate-4-phosphatase type I A; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate. Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current."},{"id":"ENSMUSP00000040575","abundance":2.2,"rank":8160,"name":"Sfmbt2","annotation":"Scm-like with four MBT domains protein 2; Transcriptional repressor of HOXB13 gene."},{"id":"ENSMUSP00000131009","abundance":2.19,"rank":8161,"name":"Vsx2","annotation":"Visual system homeobox 2; Acts as a transcriptional regulator through binding to DNA at the consensus sequence 5'-[TC]TAATT[AG][AG]-3' upstream of gene promoters. Plays a significant role in the specification and morphogenesis of the sensory retina. Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex, such as VSX1. Acts as a positive transcriptional regulator of NXNL1; regulation is significantly increased in synergy with VSX1. Acts as a negative transcr [...] "},{"id":"ENSMUSP00000131010","abundance":2.19,"rank":8162,"name":"Sphk1","annotation":"Sphingosine kinase 1; Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo- dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. In contrast to proapoptotic SPHK2, has a negative effect on intracellular ceramide levels, enhances cell growth and inhibits apoptosis. Involved in the regulation of inflammatory response and neuroinflammation. Via  [...] "},{"id":"ENSMUSP00000036699","abundance":2.19,"rank":8163,"name":"Irgq","annotation":"Immunity-related GTPase family Q protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family."},{"id":"ENSMUSP00000083490","abundance":2.19,"rank":8164,"name":"Sh2b3","annotation":"SH2B adapter protein 3; Links T-cell receptor activation signal to phospholipase C- gamma-1, GRB2 and phosphatidylinositol 3-kinase; Belongs to the SH2B adapter family."},{"id":"ENSMUSP00000033267","abundance":2.19,"rank":8165,"name":"Pdilt","annotation":"Protein disulfide-isomerase-like protein of the testis; Probable redox-inactive chaperone involved in spermatogenesis."},{"id":"ENSMUSP00000048696","abundance":2.19,"rank":8166,"name":"Tbcc","annotation":"Tubulin-specific chaperone C; Tubulin-folding protein; involved in the final step of the tubulin folding pathway."},{"id":"ENSMUSP00000128118","abundance":2.19,"rank":8167,"name":"Pdzk1ip1","annotation":"PDZK1-interacting protein 1."},{"id":"ENSMUSP00000089951","abundance":2.19,"rank":8168,"name":"Zfp750","annotation":"Zinc finger protein 750; Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression (By similarity)."},{"id":"ENSMUSP00000055271","abundance":2.19,"rank":8169,"name":"B230219D22Rik","annotation":"UPF0461 protein C5orf24 homolog; Belongs to the UPF0461 family."},{"id":"ENSMUSP00000106855","abundance":2.19,"rank":8170,"name":"Mptx2","annotation":"Pentaxin."},{"id":"ENSMUSP00000020444","abundance":2.19,"rank":8171,"name":"Llph","annotation":"Protein LLP homolog; In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission."},{"id":"ENSMUSP00000097912","abundance":2.19,"rank":8172,"name":"Commd6","annotation":"COMM domain-containing protein 6; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Inhibits TNF-induced NFKB1 activation."},{"id":"ENSMUSP00000108712","abundance":2.19,"rank":8173,"name":"Cidec","annotation":"Cell death activator CIDE-3; Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a s [...] "},{"id":"ENSMUSP00000018816","abundance":2.18,"rank":8174,"name":"Copz2","annotation":"Coatomer subunit zeta-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properti [...] "},{"id":"ENSMUSP00000058996","abundance":2.18,"rank":8175,"name":"Rimkla","annotation":"N-acetylaspartylglutamate synthase A; Catalyzes the synthesis of N-acetyl-L-aspartyl-L-glutamate (NAAG) and N-acetyl-L-aspartyl-L-glutamyl-L-glutamate."},{"id":"ENSMUSP00000023809","abundance":2.18,"rank":8176,"name":"Amhr2","annotation":"Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone."},{"id":"ENSMUSP00000021242","abundance":2.18,"rank":8177,"name":"Tac4","annotation":"Tachykinin-4; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Hemokinin induces plasma extravasation, mast cell degranulation, muscle contraction, salivary secretion and scratching behavior. Increases sperm motility. Induces potent analgesic effects and may play a role in pain modulation. Promotes survival of bone marrow B lineage cells and of cultured LPS-stimulated pre-B cells and may act as an autocrine factor required for B-cell survival and prolif [...] "},{"id":"ENSMUSP00000009522","abundance":2.18,"rank":8178,"name":"Slc16a12","annotation":"Monocarboxylate transporter 12; Proton-linked monocarboxylate transporter that mediates creatine transport across the plasma membrane."},{"id":"ENSMUSP00000104562","abundance":2.18,"rank":8179,"name":"Zfp972","annotation":"Zinc finger protein 972."},{"id":"ENSMUSP00000051846","abundance":2.18,"rank":8180,"name":"Kcnk13","annotation":"Potassium channel subfamily K member 13; Potassium channel displaying weak inward rectification in symmetrical K(+) solution; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family."},{"id":"ENSMUSP00000082503","abundance":2.18,"rank":8181,"name":"Ralgapa1","annotation":"Ral GTPase-activating protein subunit alpha-1; Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB (By similarity). May interact with the HLH region of TCF3/isoform E12."},{"id":"ENSMUSP00000044098","abundance":2.18,"rank":8182,"name":"Styk1","annotation":"Tyrosine-protein kinase STYK1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways."},{"id":"ENSMUSP00000125114","abundance":2.18,"rank":8183,"name":"Slc14a1","annotation":"Urea transporter 1; Urea channel that facilitates transmembrane urea transport down a concentration gradient. A constriction of the transmembrane channel functions as selectivity filter through which urea is expected to pass in dehydrated form. The rate of urea conduction is increased by hypotonic stress. Plays an important role in the kidney medulla collecting ducts, where it allows rapid equilibration between the lumen of the collecting ducts and the interstitium, and thereby prevents water loss driven by the high concentration of urea in the urine. Facilitates urea transport across  [...] "},{"id":"ENSMUSP00000058286","abundance":2.18,"rank":8184,"name":"C2cd4a","annotation":"C2 calcium-dependent domain-containing 4A."},{"id":"ENSMUSP00000023283","abundance":2.18,"rank":8185,"name":"Lmf2","annotation":"Lipase maturation factor 2; Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity)."},{"id":"ENSMUSP00000037525","abundance":2.18,"rank":8186,"name":"Tbc1d21","annotation":"TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity."},{"id":"ENSMUSP00000024774","abundance":2.18,"rank":8187,"name":"Guca1b","annotation":"Guanylyl cyclase-activating protein 2; Stimulates two retinal guanylyl cyclase (GCs) GUCY2E and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2E and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light."},{"id":"ENSMUSP00000072836","abundance":2.18,"rank":8188,"name":"Miga1","annotation":"Mitoguardin 1; Regulator of mitochondrial fusion. Acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD (By similarity)."},{"id":"ENSMUSP00000021479","abundance":2.18,"rank":8189,"name":"Actr10","annotation":"Actin-related protein 10; Belongs to the actin family."},{"id":"ENSMUSP00000048313","abundance":2.17,"rank":8190,"name":"Sptlc3","annotation":"Serine palmitoyltransferase 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. SPT complexes containing SPTLC3 generate shorter chain sphingoid bases compared to complexes containing SPTLC2. The SPTLC1- SPTLC3-SPTSSA isozyme uses C12-CoA, C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. On the other hand, the SPTLC1- SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent prefe [...] "},{"id":"ENSMUSP00000040245","abundance":2.17,"rank":8191,"name":"Irf8","annotation":"Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor (By similarity). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and act [...] "},{"id":"ENSMUSP00000129001","abundance":2.17,"rank":8192,"name":"Nfatc1","annotation":"Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T- lymphocytes as well as lymphoid and non-lymphoid cells (By similarity). Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function."},{"id":"ENSMUSP00000099633","abundance":2.17,"rank":8193,"name":"Trim44","annotation":"Tripartite motif-containing protein 44; May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity)."},{"id":"ENSMUSP00000030950","abundance":2.17,"rank":8194,"name":"Cptp","annotation":"Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1- phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity [...] "},{"id":"ENSMUSP00000098655","abundance":2.17,"rank":8195,"name":"Otub2","annotation":"Ubiquitin thioesterase OTUB2; Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the peptidase C65 family."},{"id":"ENSMUSP00000040078","abundance":2.17,"rank":8196,"name":"Zswim4","annotation":"Zinc finger SWIM domain-containing protein 4."},{"id":"ENSMUSP00000096136","abundance":2.17,"rank":8197,"name":"Znhit6","annotation":"Box C/D snoRNA protein 1; Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis."},{"id":"ENSMUSP00000105000","abundance":2.17,"rank":8198,"name":"Elmo3","annotation":"Engulfment and cell motility protein 3; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity)."},{"id":"ENSMUSP00000036382","abundance":2.17,"rank":8199,"name":"Fam207a","annotation":"Protein FAM207A; Belongs to the FAM207 family."},{"id":"ENSMUSP00000002011","abundance":2.17,"rank":8200,"name":"Esam","annotation":"Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction."},{"id":"ENSMUSP00000124473","abundance":2.17,"rank":8201,"name":"Sv2c","annotation":"Synaptic vesicle glycoprotein 2C; Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.  (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD). Belongs to the major facilitator superfamily."},{"id":"ENSMUSP00000054276","abundance":2.16,"rank":8202,"name":"Iqcf2","annotation":"IQ domain-containing protein F3."},{"id":"ENSMUSP00000001412","abundance":2.16,"rank":8203,"name":"Vps50","annotation":"Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN); Belongs to the syndetin family."},{"id":"ENSMUSP00000033490","abundance":2.16,"rank":8204,"name":"Ccdc120","annotation":"Coiled-coil domain-containing protein 120; Centriolar protein required for centriole subdistal appendage assembly and microtubule anchoring in interphase cells. Together with CCDC68, cooperate with subdistal appendage components ODF2, NIN and CEP170 for hierarchical subdistal appendage assembly. Recruits NIN and CEP170 to centrosomes. Also required for neurite growth (By similarity). Localizes CYTH2 to vesicles to allow its transport along neurites, and subsequent ARF6 activation and neurite growth (By similarity)."},{"id":"ENSMUSP00000108895","abundance":2.16,"rank":8205,"name":"Alpi","annotation":"Alkaline phosphatase."},{"id":"ENSMUSP00000054056","abundance":2.16,"rank":8206,"name":"Ankar","annotation":"Ankyrin and armadillo repeat-containing protein."},{"id":"ENSMUSP00000149064","abundance":2.16,"rank":8207,"name":"Olfr395","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000050258","abundance":2.16,"rank":8208,"name":"Nags","annotation":"N-acetylglutamate synthase conserved domain form; Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. Belongs to the acetyltransferase family."},{"id":"ENSMUSP00000072704","abundance":2.16,"rank":8209,"name":"Tmem40","annotation":"Transmembrane protein 40."},{"id":"ENSMUSP00000101684","abundance":2.16,"rank":8210,"name":"Adam8","annotation":"Disintegrin and metalloproteinase domain-containing protein 8; Possible involvement in extravasation of leukocytes."},{"id":"ENSMUSP00000027888","abundance":2.16,"rank":8211,"name":"Abl2","annotation":"Tyrosine-protein kinase ABL2; Non-receptor tyrosine-protein kinase that plays an ABL1- overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal [...] "},{"id":"ENSMUSP00000062333","abundance":2.16,"rank":8212,"name":"Tgfbr2","annotation":"TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] "},{"id":"ENSMUSP00000045511","abundance":2.16,"rank":8213,"name":"Rbm46","annotation":"Probable RNA-binding protein 46."},{"id":"ENSMUSP00000053027","abundance":2.16,"rank":8214,"name":"Fut4","annotation":"Alpha-(1,3)-fucosyltransferase 4; May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens."},{"id":"ENSMUSP00000101046","abundance":2.16,"rank":8215,"name":"Adarb1","annotation":"Double-stranded RNA-specific editase 1; Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependen [...] "},{"id":"ENSMUSP00000109299","abundance":2.15,"rank":8216,"name":"Znrd1","annotation":"DNA-directed RNA polymerase I subunit RPA12; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors."},{"id":"ENSMUSP00000137842","abundance":2.15,"rank":8217,"name":"Gm10251","annotation":"Predicted gene 10251."},{"id":"ENSMUSP00000106530","abundance":2.15,"rank":8218,"name":"Zfp68","annotation":"KRAB-containing zinc-finger protein KRAZ2."},{"id":"ENSMUSP00000091468","abundance":2.15,"rank":8219,"name":"Krtap9-1","annotation":"Keratin-associated protein 9-1."},{"id":"ENSMUSP00000103063","abundance":2.15,"rank":8220,"name":"Krtap4-8","annotation":"Keratin associated protein 4-8."},{"id":"ENSMUSP00000097910","abundance":2.15,"rank":8221,"name":"Lmo7","annotation":"LIM domain only 7."},{"id":"ENSMUSP00000024748","abundance":2.15,"rank":8222,"name":"Gtpbp2","annotation":"GTP-binding protein 2."},{"id":"ENSMUSP00000036410","abundance":2.15,"rank":8223,"name":"Prkab2","annotation":"5'-AMP-activated protein kinase subunit beta-2; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] "},{"id":"ENSMUSP00000112815","abundance":2.15,"rank":8224,"name":"Pttg1","annotation":"Securin; Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity a [...] "},{"id":"ENSMUSP00000139859","abundance":2.15,"rank":8225,"name":"Plin4","annotation":"Perilipin-4; May play a role in triacylglycerol packaging into adipocytes. May function as a coat protein involved in the biogenesis of lipid droplets."},{"id":"ENSMUSP00000029084","abundance":2.15,"rank":8226,"name":"Ntsr1","annotation":"Neurotensin receptor type 1; G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis."},{"id":"ENSMUSP00000058028","abundance":2.15,"rank":8227,"name":"Slc25a26","annotation":"S-adenosylmethionine mitochondrial carrier protein; Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria (By similarity)."},{"id":"ENSMUSP00000117713","abundance":2.15,"rank":8228,"name":"Mest","annotation":"Mesoderm-specific transcript protein; Belongs to the AB hydrolase superfamily."},{"id":"ENSMUSP00000012664","abundance":2.15,"rank":8229,"name":"Phox2b","annotation":"Paired mesoderm homeobox protein 2B; Belongs to the paired homeobox family."},{"id":"ENSMUSP00000049663","abundance":2.15,"rank":8230,"name":"Cpne4","annotation":"Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes. Belongs to the copine family."},{"id":"ENSMUSP00000046449","abundance":2.15,"rank":8231,"name":"Cc2d1a","annotation":"Coiled-coil and C2 domain-containing protein 1A; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Belongs to the CC2D1 family."},{"id":"ENSMUSP00000026607","abundance":2.15,"rank":8232,"name":"Chm","annotation":"Rab proteins geranylgeranyltransferase component A 1; Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative  [...] "},{"id":"ENSMUSP00000060398","abundance":2.14,"rank":8233,"name":"Patl1","annotation":"Protein PAT1 homolog 1; RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly (By similarity); Belongs to the PAT1 family."},{"id":"ENSMUSP00000067477","abundance":2.14,"rank":8234,"name":"Arhgap4","annotation":"Rho GTPase-activating protein p115 splice form 1."},{"id":"ENSMUSP00000092387","abundance":2.14,"rank":8235,"name":"Psg21","annotation":"Pregnancy-specific glycoprotein 21."},{"id":"ENSMUSP00000037328","abundance":2.14,"rank":8236,"name":"Gipc2","annotation":"PDZ domain-containing protein GIPC2; Belongs to the GIPC family."},{"id":"ENSMUSP00000029692","abundance":2.14,"rank":8237,"name":"Rit1","annotation":"GTP-binding protein Rit1; Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation (By similarity)."},{"id":"ENSMUSP00000034267","abundance":2.14,"rank":8238,"name":"Slc27a1","annotation":"Long-chain fatty acid transport protein 1; Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or trigly [...] "},{"id":"ENSMUSP00000069669","abundance":2.14,"rank":8239,"name":"Klhdc10","annotation":"Kelch domain-containing protein 10; Participates in the oxidative stress-induced cell death through MAP3K5 activation. Inhibits PPP5C phosphatase activity on MAP3K5."},{"id":"ENSMUSP00000023474","abundance":2.14,"rank":8240,"name":"Wdr53","annotation":"WD repeat-containing protein 53; Belongs to the WD repeat WDR53 family."},{"id":"ENSMUSP00000023959","abundance":2.14,"rank":8241,"name":"Grm2","annotation":"Metabotropic glutamate receptor 2; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization."},{"id":"ENSMUSP00000055562","abundance":2.14,"rank":8242,"name":"Nccrp1","annotation":"F-box only protein 50; Promotes cell proliferation."},{"id":"ENSMUSP00000107874","abundance":2.13,"rank":8243,"name":"Piga","annotation":"N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein; Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily."},{"id":"ENSMUSP00000107080","abundance":2.13,"rank":8244,"name":"Snrnp35","annotation":"U11/U12 small nuclear ribonucleoprotein 35 kDa protein."},{"id":"ENSMUSP00000033100","abundance":2.13,"rank":8245,"name":"Izumo1","annotation":"Izumo sperm-egg fusion protein 1; Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'."},{"id":"ENSMUSP00000082710","abundance":2.13,"rank":8246,"name":"Traf5","annotation":"TNF receptor-associated factor 5; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF- kappa-B by EIF2AK2/PKR."},{"id":"ENSMUSP00000037981","abundance":2.13,"rank":8247,"name":"Hdac3","annotation":"Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activi [...] "},{"id":"ENSMUSP00000045715","abundance":2.13,"rank":8248,"name":"Rgs8","annotation":"Regulator of G-protein signaling 8; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling."},{"id":"ENSMUSP00000126173","abundance":2.13,"rank":8249,"name":"Ube2f","annotation":"NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5."},{"id":"ENSMUSP00000070414","abundance":2.13,"rank":8250,"name":"St3gal5","annotation":"Lactosylceramide alpha-2,3-sialyltransferase; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide), which is a precursor for most of the complex ganglioside species."},{"id":"ENSMUSP00000040436","abundance":2.13,"rank":8251,"name":"Lgi2","annotation":"Leucine-rich repeat LGI family member 2; Required for the development of soma-targeting inhibitory GABAergic synapses made by parvalbumin-positive basket cells."},{"id":"ENSMUSP00000158030","abundance":2.13,"rank":8252,"name":"Gpr22","annotation":"G-protein coupled receptor 22; Orphan G-protein coupled receptor. Seems to act through a G(i)/G(o) mediated pathway (By similarity). May be involved in ciliogenesis (By similarity)."},{"id":"ENSMUSP00000027992","abundance":2.13,"rank":8253,"name":"Enkur","annotation":"Enkurin; Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel."},{"id":"ENSMUSP00000046991","abundance":2.13,"rank":8254,"name":"Wipf2","annotation":"WAS/WASL-interacting protein family member 2; Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system (By similarity)."},{"id":"ENSMUSP00000065664","abundance":2.13,"rank":8255,"name":"Foxi3","annotation":"Forkhead box I3."},{"id":"ENSMUSP00000095200","abundance":2.13,"rank":8256,"name":"Arhgap26","annotation":"Rho GTPase-activating protein 26; GTPase-activating protein for RHOA and CDC42."},{"id":"ENSMUSP00000145975","abundance":2.13,"rank":8257,"name":"Irgc1","annotation":"Interferon-inducible GTPase 5."},{"id":"ENSMUSP00000067682","abundance":2.13,"rank":8258,"name":"Dgcr6","annotation":"Protein DGCR6; May have a role in early embryogenesis; Belongs to the gonadal family."},{"id":"ENSMUSP00000129831","abundance":2.13,"rank":8259,"name":"Ripk1","annotation":"Receptor-interacting serine/threonine-protein kinase 1; Serine-threonine kinase which is a key regulator of both cell death and cell survival. Exhibits kinase activity- dependent functions that trigger cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Initiates ripoptocide which describes cell death that is dependent on RIPK1, be it apoptosis or necroptosis. Upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, [...] "},{"id":"ENSMUSP00000136074","abundance":2.13,"rank":8260,"name":"Zfp872","annotation":"Zinc finger protein 872."},{"id":"ENSMUSP00000128504","abundance":2.12,"rank":8261,"name":"Daxx","annotation":"Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] "},{"id":"ENSMUSP00000019071","abundance":2.12,"rank":8262,"name":"Ccl6","annotation":"C-C motif chemokine 6; CCL6(22-95) and CCL6(23-95) are potent chemoattractants. Belongs to the intercrine beta (chemokine CC) family."},{"id":"ENSMUSP00000042433","abundance":2.12,"rank":8263,"name":"Ddx58","annotation":"Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] "},{"id":"ENSMUSP00000061893","abundance":2.12,"rank":8264,"name":"Abi3","annotation":"ABI gene family member 3; Inhibits ectopic tumor cell metastasis of SRD cells. In vitro, reduces cell motility; Belongs to the ABI family."},{"id":"ENSMUSP00000154478","abundance":2.12,"rank":8265,"name":"Nudcd1","annotation":"NudC domain-containing protein 1."},{"id":"ENSMUSP00000080085","abundance":2.12,"rank":8266,"name":"Rrp1b","annotation":"Ribosomal RNA processing protein 1 homolog B; Positively regulates DNA damage-induced apoptosis by acting as a transcriptional coactivator of proapoptotic target genes of the transcriptional activator E2F1 (By similarity). Likely to play a role in ribosome biogenesis by targeting serine/threonine protein phosphatase PP1 to the nucleolus (By similarity). Involved in regulation of mRNA splicing. Inhibits SIPA1 GTPase activity. Involved in regulating expression of extracellular matrix genes. Associates with chromatin and may play a role in modulating chromatin structure (By similarity). B [...] "},{"id":"ENSMUSP00000112508","abundance":2.12,"rank":8267,"name":"Trp53bp2","annotation":"Apoptosis-stimulating of p53 protein 2; Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53 (By similarity). Regulates p53/TP53 by enhancing the DNA binding and transactivation function of p53/TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis- stimulating activity is inhibited by its interaction with DDX42 (By similarity); Belongs to the ASP [...] "},{"id":"ENSMUSP00000007738","abundance":2.12,"rank":8268,"name":"Hapln4","annotation":"Hyaluronan and proteoglycan link protein 4; Binds to hyaluronic acid and may be involved in formation of the extracellular matrix; Belongs to the HAPLN family."},{"id":"ENSMUSP00000052661","abundance":2.12,"rank":8269,"name":"Adam5","annotation":"Disintegrin and metalloproteinase domain-containing protein 5; This is a non catalytic metalloprotease-like protein. May play a role in sperm-egg fusion (By similarity)."},{"id":"ENSMUSP00000102872","abundance":2.12,"rank":8270,"name":"Pi4kb","annotation":"Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity); Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily."},{"id":"ENSMUSP00000034868","abundance":2.12,"rank":8271,"name":"Clk1","annotation":"Dual specificity protein kinase CLK1; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA."},{"id":"ENSMUSP00000037752","abundance":2.12,"rank":8272,"name":"Tph1","annotation":"Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family."},{"id":"ENSMUSP00000074885","abundance":2.12,"rank":8273,"name":"Cxcl2","annotation":"C-X-C motif chemokine 2; Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst."},{"id":"ENSMUSP00000035053","abundance":2.11,"rank":8274,"name":"Nme6","annotation":"Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family."},{"id":"ENSMUSP00000019101","abundance":2.11,"rank":8275,"name":"Scml2","annotation":"Scm polycomb group protein-like 2."},{"id":"ENSMUSP00000032182","abundance":2.11,"rank":8276,"name":"Xpc","annotation":"DNA repair protein complementing XP-C cells homolog; Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen- bonded bases by forming a transient nucleoprotein intermediate complex which ma [...] "},{"id":"ENSMUSP00000072020","abundance":2.11,"rank":8277,"name":"Tiam2","annotation":"T-lymphoma invasion and metastasis-inducing protein 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates specifically RAC1, but not CDC42 and RHOA. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cort [...] "},{"id":"ENSMUSP00000047359","abundance":2.11,"rank":8278,"name":"Pitx2","annotation":"Pituitary homeobox 2; Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform Ptx2c is involved in left-right asymmetry the developing embryo."},{"id":"ENSMUSP00000053440","abundance":2.11,"rank":8279,"name":"Grpel2","annotation":"GrpE protein homolog 2, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins. Stimulates ATPase activity of mt-HSP70. May also serve to modulate the interconversion of oligomeric (inactive) and monomeric (active) forms of mt-HSP70; Belongs to the GrpE family."},{"id":"ENSMUSP00000064775","abundance":2.11,"rank":8280,"name":"Adarb2","annotation":"Double-stranded RNA-specific editase B2; Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA (By similarity)."},{"id":"ENSMUSP00000031390","abundance":2.11,"rank":8281,"name":"Mmp17","annotation":"Matrix metalloproteinase-17; Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin."},{"id":"ENSMUSP00000113390","abundance":2.11,"rank":8282,"name":"Clk2","annotation":"Dual specificity protein kinase CLK2; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphor [...] "},{"id":"ENSMUSP00000102521","abundance":2.11,"rank":8283,"name":"Pde4b","annotation":"Phosphodiesterase."},{"id":"ENSMUSP00000128621","abundance":2.11,"rank":8284,"name":"Gdf10","annotation":"Growth/differentiation factor 10; Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis."},{"id":"ENSMUSP00000022574","abundance":2.11,"rank":8285,"name":"Lrrc63","annotation":"Leucine-rich repeat-containing protein 63."},{"id":"ENSMUSP00000019859","abundance":2.11,"rank":8286,"name":"Gle1","annotation":"Nucleoporin GLE1; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) (By similarity)."},{"id":"ENSMUSP00000058950","abundance":2.11,"rank":8287,"name":"Ddx28","annotation":"Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (By similarity); Belongs to the DEAD box helicase family."},{"id":"ENSMUSP00000126338","abundance":2.11,"rank":8288,"name":"Zfp148","annotation":"Zinc finger protein 148; Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000104438","abundance":2.11,"rank":8289,"name":"Trim11","annotation":"E3 ubiquitin-protein ligase TRIM11; E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation  [...] "},{"id":"ENSMUSP00000107415","abundance":2.11,"rank":8290,"name":"Itprid2","annotation":"Protein ITPRID2."},{"id":"ENSMUSP00000062930","abundance":2.1,"rank":8291,"name":"Slbp","annotation":"Histone RNA hairpin-binding protein; RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expressio [...] "},{"id":"ENSMUSP00000114404","abundance":2.1,"rank":8292,"name":"Ikzf4","annotation":"Zinc finger protein Eos; DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros- binding sequence. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T- cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T- cells (Treg) via recruitment of corepressor CTBP1."},{"id":"ENSMUSP00000046027","abundance":2.1,"rank":8293,"name":"Itpk1","annotation":"Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate I [...] "},{"id":"ENSMUSP00000049494","abundance":2.1,"rank":8294,"name":"Cyp3a59","annotation":"Cytochrome P450, family 3, subfamily a, polypeptide 59."},{"id":"ENSMUSP00000034766","abundance":2.1,"rank":8295,"name":"Rora","annotation":"Nuclear receptor ROR-alpha; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity [...] "},{"id":"ENSMUSP00000037519","abundance":2.1,"rank":8296,"name":"Sox30","annotation":"Transcription factor SOX-30; Acts as both a transcriptional activator and repressor. Binds to the DNA sequence 5'-ACAAT- 3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity)."},{"id":"ENSMUSP00000108517","abundance":2.1,"rank":8297,"name":"Tmem164","annotation":"Transmembrane protein 164."},{"id":"ENSMUSP00000103324","abundance":2.09,"rank":8298,"name":"Zfp189","annotation":"Zinc finger protein 189."},{"id":"ENSMUSP00000079172","abundance":2.09,"rank":8299,"name":"Cd6","annotation":"T-cell differentiation antigen CD6; Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex. Functions as costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as calcium-dependent pattern receptor that binds and aggregates both Gram- positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and li [...] "},{"id":"ENSMUSP00000136280","abundance":2.09,"rank":8300,"name":"Dpf3","annotation":"Zinc finger protein DPF3; Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development (By similarity). Belongs to the neuron-spec [...] "},{"id":"ENSMUSP00000025374","abundance":2.09,"rank":8301,"name":"Pou4f3","annotation":"POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear ; Belongs to the POU transcription factor family. Class-4 subfamily."},{"id":"ENSMUSP00000036860","abundance":2.09,"rank":8302,"name":"Oxld1","annotation":"Oxidoreductase-like domain-containing protein 1."},{"id":"ENSMUSP00000124855","abundance":2.09,"rank":8303,"name":"Cmtm1","annotation":"CKLF-like MARVEL transmembrane domain-containing 1."},{"id":"ENSMUSP00000047980","abundance":2.09,"rank":8304,"name":"Vps37b","annotation":"Vacuolar protein sorting-associated protein 37B; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity)."},{"id":"ENSMUSP00000091389","abundance":2.09,"rank":8305,"name":"Olfr894","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000065198","abundance":2.09,"rank":8306,"name":"Ddx10","annotation":"Probable ATP-dependent RNA helicase DDX10; Putative ATP-dependent RNA helicase."},{"id":"ENSMUSP00000067647","abundance":2.09,"rank":8307,"name":"Stpg1","annotation":"O(6)-methylguanine-induced apoptosis 2; May positively contribute to the induction of apoptosis triggered by O(6)-methylguanine."},{"id":"ENSMUSP00000046654","abundance":2.09,"rank":8308,"name":"Snrnp25","annotation":"U11/U12 small nuclear ribonucleoprotein 25 kDa protein."},{"id":"ENSMUSP00000030964","abundance":2.09,"rank":8309,"name":"Cd38","annotation":"ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; Synthesizes the second messengers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity (By similarity)."},{"id":"ENSMUSP00000031318","abundance":2.09,"rank":8310,"name":"Cxcl5","annotation":"C-X-C motif chemokine 5; May participate in the recruitment of inflammatory cells by injured or infected tissue. GCP-2(1-78) and, more potent, GCP-2(9-78) attract neutrophils and are involved in neutrophil activation."},{"id":"ENSMUSP00000110652","abundance":2.09,"rank":8311,"name":"Xpnpep2","annotation":"Xaa-Pro aminopeptidase 2; Membrane-bound metalloprotease which catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Arg-Pro-Pro. May play a role in the metabolism of the vasodilator bradykinin; Belongs to the peptidase M24B family."},{"id":"ENSMUSP00000033825","abundance":2.09,"rank":8312,"name":"Adprhl1","annotation":"[Protein ADP-ribosylarginine] hydrolase-like protein 1; Seems not to catalyse the hydrolysis of O-acetyl-ADP-ribose."},{"id":"ENSMUSP00000035208","abundance":2.09,"rank":8313,"name":"Bsn","annotation":"Protein bassoon; Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released. After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Functions also in [...] "},{"id":"ENSMUSP00000134963","abundance":2.09,"rank":8314,"name":"Peg10","annotation":"Retrotransposon-derived protein PEG10; May have a role in cell growth promotion, apoptotic resistance and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1 (By similarity). Involved at the immediate early stage of adipocyte differentiation. May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter."},{"id":"ENSMUSP00000127715","abundance":2.09,"rank":8315,"name":"Tns1","annotation":"Tensin 1."},{"id":"ENSMUSP00000138028","abundance":2.09,"rank":8316,"name":"Gm2916","annotation":"Predicted gene 2916."},{"id":"ENSMUSP00000102699","abundance":2.09,"rank":8317,"name":"Chrdl2","annotation":"Chordin-like protein 2; Implicated in tumor angiogenesis (By similarity). May inhibits BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation. May play a role during myoblast and osteoblast differentiation, and maturation."},{"id":"ENSMUSP00000032520","abundance":2.09,"rank":8318,"name":"Ceacam12","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 12."},{"id":"ENSMUSP00000079651","abundance":2.09,"rank":8319,"name":"Xlr3c","annotation":"X-linked lymphocyte-regulated protein 3C."},{"id":"ENSMUSP00000060147","abundance":2.09,"rank":8320,"name":"Gpa33","annotation":"Cell surface A33 antigen; May play a role in cell-cell recognition and signaling."},{"id":"ENSMUSP00000025264","abundance":2.08,"rank":8321,"name":"Wdr33","annotation":"pre-mRNA 3' end processing protein WDR33; Essential for both cleavage and polyadenylation of pre-mRNA 3' ends; Belongs to the WD repeat WDR33 family."},{"id":"ENSMUSP00000092399","abundance":2.08,"rank":8322,"name":"Ccdc8","annotation":"Coiled-coil domain-containing protein 8 homolog; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Required for localization of CUL7 to the centrosome."},{"id":"ENSMUSP00000024660","abundance":2.08,"rank":8323,"name":"Smoc2","annotation":"SPARC-related modular calcium-binding protein 2; Can stimulate endothelial cell proliferation, migration, as well as angiogenesis (By similarity). Promotes matrix assembly and cell adhesiveness."},{"id":"ENSMUSP00000033910","abundance":2.08,"rank":8324,"name":"Leprotl1","annotation":"Leptin receptor overlapping transcript-like 1; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. Belongs to the OB-RGRP/VPS55 family."},{"id":"ENSMUSP00000029421","abundance":2.08,"rank":8325,"name":"Ptx3","annotation":"Pentraxin-related protein PTX3; Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self- components and female fertility."},{"id":"ENSMUSP00000036138","abundance":2.08,"rank":8326,"name":"Cmtm5","annotation":"CKLF-like MARVEL transmembrane domain-containing protein 5; Belongs to the chemokine-like factor family."},{"id":"ENSMUSP00000130176","abundance":2.08,"rank":8327,"name":"Zfp385a","annotation":"Zinc finger protein 385A; RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'- UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p [...] "},{"id":"ENSMUSP00000093430","abundance":2.08,"rank":8328,"name":"Nat8f4","annotation":"N-acetyltransferase 8 (GCN5-related) family member 4."},{"id":"ENSMUSP00000071194","abundance":2.08,"rank":8329,"name":"Fuz","annotation":"Protein fuzzy homolog; Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia. Belongs to the fuzzy family."},{"id":"ENSMUSP00000023568","abundance":2.08,"rank":8330,"name":"Chodl","annotation":"Chondrolectin; May play a role in the development of the nervous system such as in neurite outgrowth and elongation. May be involved in motor axon growth and guidance (By similarity)."},{"id":"ENSMUSP00000058037","abundance":2.07,"rank":8331,"name":"Zfpm1","annotation":"Zinc finger protein ZFPM1; Transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. May be involved in regulation of som [...] "},{"id":"ENSMUSP00000125352","abundance":2.07,"rank":8332,"name":"Gtpbp8","annotation":"GTP-binding protein 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family."},{"id":"ENSMUSP00000148080","abundance":2.07,"rank":8333,"name":"Il18bp","annotation":"Interleukin-18-binding protein; Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity)."},{"id":"ENSMUSP00000043015","abundance":2.07,"rank":8334,"name":"Tsga8","annotation":"Testis-specific gene A8 protein."},{"id":"ENSMUSP00000048263","abundance":2.07,"rank":8335,"name":"Nutm1","annotation":"NUT family member 1; Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites; Belongs to the NUT family."},{"id":"ENSMUSP00000147656","abundance":2.07,"rank":8336,"name":"Ptpre","annotation":"Receptor-type tyrosine-protein phosphatase epsilon; Isoform 1 acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver (By similarity). Plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function.  Isoform 1 and isoform 2 act as a negative regulator of FceRI- mediated signal transduction leading to cytokine production and degranulation [...] "},{"id":"ENSMUSP00000042792","abundance":2.07,"rank":8337,"name":"Msl1","annotation":"Male-specific lethal 1 homolog; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-16' (H4K16ac) which is implicated in the formation of higher-order chromatin structure. Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub) (By similarity). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity). In the MSL complex, acts as a scaffold to  [...] "},{"id":"ENSMUSP00000101286","abundance":2.07,"rank":8338,"name":"Plekhg5","annotation":"Pleckstrin homology domain-containing family G member 5; Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons. Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity)."},{"id":"ENSMUSP00000142890","abundance":2.07,"rank":8339,"name":"Chd8","annotation":"Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] "},{"id":"ENSMUSP00000029085","abundance":2.07,"rank":8340,"name":"Mrgbp","annotation":"MRG/MORF4L-binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] "},{"id":"ENSMUSP00000102906","abundance":2.07,"rank":8341,"name":"Ezh1","annotation":"Histone-lysine N-methyltransferase EZH1; Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase a [...] "},{"id":"ENSMUSP00000034876","abundance":2.07,"rank":8342,"name":"Tspan3","annotation":"Tetraspanin-3; Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair."},{"id":"ENSMUSP00000023693","abundance":2.07,"rank":8343,"name":"Ifnar2","annotation":"Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN- mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 2 and isoform 3 may be potent inhibitors of type I IFN receptor activity."},{"id":"ENSMUSP00000019135","abundance":2.07,"rank":8344,"name":"Gga3","annotation":"ADP-ribosylation factor-binding protein GGA3; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (By similarity)."},{"id":"ENSMUSP00000102014","abundance":2.07,"rank":8345,"name":"Kdm4a","annotation":"Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys- 4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By s [...] "},{"id":"ENSMUSP00000005015","abundance":2.07,"rank":8346,"name":"Prcc","annotation":"Papillary Renal Cell carcinoma (Translocation-associated)."},{"id":"ENSMUSP00000140036","abundance":2.07,"rank":8347,"name":"Srcap","annotation":"Snf2-related CREBBP activator protein."},{"id":"ENSMUSP00000118729","abundance":2.07,"rank":8348,"name":"March11","annotation":"E3 ubiquitin-protein ligase MARCHF11; E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids."},{"id":"ENSMUSP00000058680","abundance":2.07,"rank":8349,"name":"Slc35f6","annotation":"Solute carrier family 35 member F6; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (By similarity)."},{"id":"ENSMUSP00000112500","abundance":2.07,"rank":8350,"name":"Atg16l2","annotation":"Autophagy-related protein 16-2; May play a role in autophagy."},{"id":"ENSMUSP00000034079","abundance":2.07,"rank":8351,"name":"Heatr3","annotation":"HEAT repeat-containing protein 3."},{"id":"ENSMUSP00000063027","abundance":2.07,"rank":8352,"name":"Zfp459","annotation":"Zinc finger protein 459."},{"id":"ENSMUSP00000060798","abundance":2.07,"rank":8353,"name":"Pou4f1","annotation":"POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Ativates BCL2 expression and protects ne [...] "},{"id":"ENSMUSP00000043286","abundance":2.07,"rank":8354,"name":"Pnpla8","annotation":"Calcium-independent phospholipase A2-gamma; Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Cleaves membrane phospholipids (By similarity)."},{"id":"ENSMUSP00000080979","abundance":2.06,"rank":8355,"name":"Luzp2","annotation":"Leucine zipper protein 2."},{"id":"ENSMUSP00000036571","abundance":2.06,"rank":8356,"name":"Nol4l","annotation":"Nucleolar protein 4-like."},{"id":"ENSMUSP00000137260","abundance":2.06,"rank":8357,"name":"Bcap29","annotation":"B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8- mediated apoptosis (By similarity); Belongs to the BCAP29/BCAP31 family."},{"id":"ENSMUSP00000018748","abundance":2.06,"rank":8358,"name":"Tbx3","annotation":"T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (By similarity)."},{"id":"ENSMUSP00000112630","abundance":2.06,"rank":8359,"name":"Hcrtr1","annotation":"Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000036141","abundance":2.06,"rank":8360,"name":"Amdhd2","annotation":"N-acetylglucosamine-6-phosphate deacetylase; Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6- phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway; Belongs to the metallo-dependent hydrolases superfamily. NagA family."},{"id":"ENSMUSP00000041963","abundance":2.06,"rank":8361,"name":"Muc1","annotation":"Mucin-1 subunit alpha; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack."},{"id":"ENSMUSP00000033464","abundance":2.06,"rank":8362,"name":"Brs3","annotation":"Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system."},{"id":"ENSMUSP00000127653","abundance":2.06,"rank":8363,"name":"Phf8","annotation":"Histone lysine demethylase PHF8; Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys- 20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivato [...] "},{"id":"ENSMUSP00000128446","abundance":2.06,"rank":8364,"name":"Ap3m2","annotation":"AP-3 complex subunit mu-2; Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Ap47 is a subunit of the plasma membrane adaptor (By similarity). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals."},{"id":"ENSMUSP00000085816","abundance":2.06,"rank":8365,"name":"Clec4a3","annotation":"C-type lectin domain family 4, member a3."},{"id":"ENSMUSP00000099484","abundance":2.06,"rank":8366,"name":"Znhit3","annotation":"Zinc finger HIT domain-containing protein 3."},{"id":"ENSMUSP00000103930","abundance":2.05,"rank":8367,"name":"Unc119","annotation":"Protein unc-119 homolog A; Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Proba [...] "},{"id":"ENSMUSP00000143986","abundance":2.05,"rank":8368,"name":"Gm43638","annotation":"Predicted gene 43638; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000112099","abundance":2.05,"rank":8369,"name":"Cfap61","annotation":"Cilia- and flagella-associated protein 61; May regulate cilium motility through its role in the assembly of the axonemal radial spokes."},{"id":"ENSMUSP00000029158","abundance":2.05,"rank":8370,"name":"Aar2","annotation":"Protein AAR2 homolog; Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. Belongs to the AAR2 family."},{"id":"ENSMUSP00000091452","abundance":2.05,"rank":8371,"name":"Cdc27","annotation":"Cell division cycle protein 27 homolog; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC3/CDC27 family."},{"id":"ENSMUSP00000140287","abundance":2.05,"rank":8372,"name":"Ly6a","annotation":"Lymphocyte antigen 6A-2/6E-1; T-cell activation."},{"id":"ENSMUSP00000136259","abundance":2.05,"rank":8373,"name":"Gm49322","annotation":"Predicted gene, 49322."},{"id":"ENSMUSP00000040551","abundance":2.05,"rank":8374,"name":"Adat3","annotation":"Probable inactive tRNA-specific adenosine deaminase-like protein 3."},{"id":"ENSMUSP00000021450","abundance":2.05,"rank":8375,"name":"Sgpp1","annotation":"Sphingosine-1-phosphate phosphatase 1; Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1-phosphate, lysophosphatidic acid or phosphatidic acid. Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger. Involved in efficient ceramide syn [...] "},{"id":"ENSMUSP00000152954","abundance":2.05,"rank":8376,"name":"Ints6","annotation":"Integrator complex subunit 6; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex."},{"id":"ENSMUSP00000099688","abundance":2.05,"rank":8377,"name":"Yrdc","annotation":"YrdC domain-containing protein, mitochondrial; May regulate the activity of some transporters."},{"id":"ENSMUSP00000093758","abundance":2.05,"rank":8378,"name":"Slf2","annotation":"SMC5-SMC6 complex localization factor protein 2; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of the SMC5-SMC6 complex to DNA lesions."},{"id":"ENSMUSP00000139261","abundance":2.05,"rank":8379,"name":"Kctd12","annotation":"BTB/POZ domain-containing protein KCTD12; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization."},{"id":"ENSMUSP00000139601","abundance":2.05,"rank":8380,"name":"Myrf","annotation":"Myelin regulatory factor, C-terminal; [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes.  [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specif [...] "},{"id":"ENSMUSP00000099026","abundance":2.05,"rank":8381,"name":"Xlr3b","annotation":"X-linked lymphocyte-regulated protein 3B; Belongs to the XLR/SYCP3 family."},{"id":"ENSMUSP00000109653","abundance":2.05,"rank":8382,"name":"Rexo4","annotation":"RNA exonuclease 4; May function as an exonuclease."},{"id":"ENSMUSP00000156559","abundance":2.05,"rank":8383,"name":"Cdkn1a","annotation":"Cyclin-dependent kinase inhibitor 1; May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin- dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D- CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3  [...] "},{"id":"ENSMUSP00000041456","abundance":2.05,"rank":8384,"name":"Wdr45","annotation":"WD repeat domain phosphoinositide-interacting protein 4; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes. Probably recruited to membranes through its PtdIns3P activity. Belongs to the WD repeat SVP1 family."},{"id":"ENSMUSP00000035020","abundance":2.05,"rank":8385,"name":"Eomes","annotation":"Eomesodermin homolog; Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes."},{"id":"ENSMUSP00000023886","abundance":2.04,"rank":8386,"name":"Sult1c2","annotation":"Sulfotransferase 1C2; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of drugs, xenobiotic compounds, hormones, and neurotransmitters."},{"id":"ENSMUSP00000079908","abundance":2.04,"rank":8387,"name":"Gm648","annotation":"Gene model 648, (NCBI)."},{"id":"ENSMUSP00000014058","abundance":2.04,"rank":8388,"name":"Klk10","annotation":"Kallikrein-related-peptidase 10; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000065746","abundance":2.04,"rank":8389,"name":"Sp8","annotation":"Transcription factor Sp8; Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos. Belongs to the Sp1 C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000044134","abundance":2.04,"rank":8390,"name":"Abhd4","annotation":"(Lyso)-N-acylphosphatidylethanolamine lipase; Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N- acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatid [...] "},{"id":"ENSMUSP00000005671","abundance":2.04,"rank":8391,"name":"Igf1r","annotation":"Insulin-like growth factor 1 receptor alpha chain; Receptor tyrosine kinase which mediates actions of insulin- like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates ( [...] "},{"id":"ENSMUSP00000029047","abundance":2.04,"rank":8392,"name":"Snx16","annotation":"Sorting nexin-16; May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity); Belongs to the sorting nexin family."},{"id":"ENSMUSP00000136780","abundance":2.04,"rank":8393,"name":"Ccl21a-2","annotation":"C-C motif chemokine 21a."},{"id":"ENSMUSP00000092732","abundance":2.04,"rank":8394,"name":"Ccl21a","annotation":"C-C motif chemokine 21a; Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs; Belongs to the intercrine beta (chemokine CC) family."},{"id":"ENSMUSP00000068067","abundance":2.04,"rank":8395,"name":"Bhlhb9","annotation":"Protein BHLHb9; May play a role in the control of cellular aging and survival; Belongs to the GPRASP family."},{"id":"ENSMUSP00000142694","abundance":2.04,"rank":8396,"name":"Gm43738","annotation":"Predicted gene 43738."},{"id":"ENSMUSP00000003961","abundance":2.04,"rank":8397,"name":"Ppfia3","annotation":"Liprin-alpha-3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. Belongs to the liprin family. Liprin-alpha subfamily."},{"id":"ENSMUSP00000044608","abundance":2.04,"rank":8398,"name":"Enpp6","annotation":"Glycerophosphocholine cholinephosphodiesterase ENPP6; Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids."},{"id":"ENSMUSP00000041175","abundance":2.04,"rank":8399,"name":"Cyp2s1","annotation":"Cytochrome P450 2S1; A cytochrome P450 monooxygenase involved in the metabolism of retinoids and eicosanoids. In epidermis, may contribute to the oxidative metabolism of all-trans-retinoic acid. For this activity, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Additionally, displays peroxidase and isomerase activities toward various oxygenated eicosanoids such as prostaglandin H2 (PGH2) and hydroperoxyeicosatetraenoates (HP [...] "},{"id":"ENSMUSP00000028389","abundance":2.04,"rank":8400,"name":"Frzb","annotation":"Secreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity)."},{"id":"ENSMUSP00000021513","abundance":2.04,"rank":8401,"name":"Gsc","annotation":"Homeobox protein goosecoid; Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis (By similarity). In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Goosecoid-expressing regions of the gastrulating mouse egg cylinder have organizer-like activity when transplanted into Xenopus embryos. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm [...] "},{"id":"ENSMUSP00000119724","abundance":2.04,"rank":8402,"name":"Mtfr1","annotation":"Mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission. Belongs to the MTFR1 family."},{"id":"ENSMUSP00000006662","abundance":2.03,"rank":8403,"name":"Prl8a9","annotation":"Prolactin-8A9."},{"id":"ENSMUSP00000023924","abundance":2.03,"rank":8404,"name":"Rpp14","annotation":"Ribonuclease P protein subunit p14; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family."},{"id":"ENSMUSP00000000388","abundance":2.03,"rank":8405,"name":"Ccm2","annotation":"Cerebral cavernous malformations protein 2 homolog; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock."},{"id":"ENSMUSP00000023478","abundance":2.03,"rank":8406,"name":"Igsf11","annotation":"Immunoglobulin superfamily member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth (By similarity)."},{"id":"ENSMUSP00000147784","abundance":2.03,"rank":8407,"name":"Gab1","annotation":"GRB2-associated-binding protein 1; Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway."},{"id":"ENSMUSP00000020677","abundance":2.03,"rank":8408,"name":"Upp1","annotation":"Uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis; Belongs to the PNP/UDP phosphorylase family."},{"id":"ENSMUSP00000033159","abundance":2.03,"rank":8409,"name":"Ears2","annotation":"Probable glutamate--tRNA ligase, mitochondrial; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)."},{"id":"ENSMUSP00000086314","abundance":2.03,"rank":8410,"name":"Bpifb9a","annotation":"Vomeromodulin."},{"id":"ENSMUSP00000028295","abundance":2.03,"rank":8411,"name":"Dnlz","annotation":"DNL-type zinc finger protein; May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation."},{"id":"ENSMUSP00000055229","abundance":2.03,"rank":8412,"name":"Ubqln3","annotation":"Ubiquilin-3."},{"id":"ENSMUSP00000071147","abundance":2.03,"rank":8413,"name":"Klrc3","annotation":"Killer cell lectin-like receptor subfamily C, member 3."},{"id":"ENSMUSP00000025215","abundance":2.03,"rank":8414,"name":"Sil1","annotation":"Nucleotide exchange factor SIL1; Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5 (By similarity)."},{"id":"ENSMUSP00000085566","abundance":2.03,"rank":8415,"name":"Fmnl3","annotation":"Formin-like protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis. In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement. Belongs to the formin homology family."},{"id":"ENSMUSP00000114904","abundance":2.02,"rank":8416,"name":"Aire","annotation":"Autoimmune regulator; Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue- restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (Probable). Binds to G-doublets in an A/T- rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'L [...] "},{"id":"ENSMUSP00000019791","abundance":2.02,"rank":8417,"name":"Sema6a","annotation":"Semaphorin-6A; Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. Belongs to the semaphorin family."},{"id":"ENSMUSP00000105594","abundance":2.02,"rank":8418,"name":"Pax1","annotation":"Paired box protein Pax-1; This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column."},{"id":"ENSMUSP00000020864","abundance":2.02,"rank":8419,"name":"Pctp","annotation":"Phosphatidylcholine transfer protein; Catalyzes the transfer of phosphatidylcholine between membranes. Binds a single lipid molecule."},{"id":"ENSMUSP00000024200","abundance":2.02,"rank":8420,"name":"Cela3a","annotation":"Chymotrypsin-like elastase family, member 3A; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000034045","abundance":2.02,"rank":8421,"name":"Cenpu","annotation":"Centromere protein U; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in tra [...] "},{"id":"ENSMUSP00000038504","abundance":2.02,"rank":8422,"name":"Jakmip1","annotation":"Janus kinase and microtubule-interacting protein 1; Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. Belongs to the JAKMIP family."},{"id":"ENSMUSP00000070071","abundance":2.02,"rank":8423,"name":"Zbtb26","annotation":"Zinc finger and BTB domain-containing 26."},{"id":"ENSMUSP00000030189","abundance":2.02,"rank":8424,"name":"Gba2","annotation":"Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. Glucosylceramides are membrane glycosphingolipids that have a wide intracellular distribution. They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties. Also involved in the transglucosylation of cholesterol, transferring glucose from glucosylceramides, thereby modifying its water solubility and biological  [...] "},{"id":"ENSMUSP00000079309","abundance":2.02,"rank":8425,"name":"Tbpl2","annotation":"TATA box-binding protein-like protein 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process."},{"id":"ENSMUSP00000029131","abundance":2.02,"rank":8426,"name":"Ggt7","annotation":"Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates."},{"id":"ENSMUSP00000100676","abundance":2.02,"rank":8427,"name":"Gm11564","annotation":"Predicted gene 11564."},{"id":"ENSMUSP00000149264","abundance":2.02,"rank":8428,"name":"Olfr464","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000069851","abundance":2.02,"rank":8429,"name":"Itpkb","annotation":"Kinase; Belongs to the inositol phosphokinase (IPK) family."},{"id":"ENSMUSP00000070203","abundance":2.01,"rank":8430,"name":"Depp1","annotation":"Protein DEPP1; Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS."},{"id":"ENSMUSP00000136988","abundance":2.01,"rank":8431,"name":"Cldn12","annotation":"Claudin-12; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity."},{"id":"ENSMUSP00000031364","abundance":2.01,"rank":8432,"name":"Sdad1","annotation":"Protein SDA1 homolog; Required for 60S pre-ribosomal subunits export to the cytoplasm."},{"id":"ENSMUSP00000011450","abundance":2.01,"rank":8433,"name":"Sugp1","annotation":"SURP and G-patch domain-containing protein 1; Plays a role in pre-mRNA splicing."},{"id":"ENSMUSP00000154020","abundance":2.01,"rank":8434,"name":"Lmbrd2","annotation":"G-protein coupled receptor-associated protein LMBRD2; Recruited to ligand-activated beta-2 adrenergic receptor/ADRB2, it negatively regulates the adrenergic receptor signaling pathway. May also regulate other G-protein coupled receptors including type-1 angiotensin II receptor/AGTR1."},{"id":"ENSMUSP00000041750","abundance":2.01,"rank":8435,"name":"Fbxw17","annotation":"F-box and WD-40 domain protein 17."},{"id":"ENSMUSP00000056461","abundance":2.01,"rank":8436,"name":"Arhgap15","annotation":"Rho GTPase-activating protein 15; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction (By similarity)."},{"id":"ENSMUSP00000086485","abundance":2.01,"rank":8437,"name":"Pde10a","annotation":"cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition."},{"id":"ENSMUSP00000028098","abundance":2.01,"rank":8438,"name":"Orc4","annotation":"Origin recognition complex subunit 4; Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 (By similarity). Component of the origin recognition complex (ORC) that binds origins of replication. DNA- binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication."},{"id":"ENSMUSP00000158987","abundance":2.01,"rank":8439,"name":"Tmem134","annotation":"Transmembrane protein 134; Belongs to the TMEM134/TMEM230 family."},{"id":"ENSMUSP00000049852","abundance":2.01,"rank":8440,"name":"Fzd4","annotation":"Frizzled-4; Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and sti [...] "},{"id":"ENSMUSP00000116200","abundance":2.01,"rank":8441,"name":"Pdlim2","annotation":"PDZ and LIM domain protein 2; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity)."},{"id":"ENSMUSP00000159111","abundance":2.01,"rank":8442,"name":"Foxi2","annotation":"Forkhead box protein I2; Possible transcriptional activator."},{"id":"ENSMUSP00000043957","abundance":2.01,"rank":8443,"name":"Lama1","annotation":"Laminin subunit alpha-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."},{"id":"ENSMUSP00000048768","abundance":2.01,"rank":8444,"name":"Kdf1","annotation":"Keratinocyte differentiation factor 1; Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny."},{"id":"ENSMUSP00000076505","abundance":2.01,"rank":8445,"name":"Ext1","annotation":"Exostosin-1; Glycosyltransferase required for the biosynthesis of heparan- sulfate. The EXT1/EXT2 complex possesses substantially higher glycosyltransferase activity than EXT1 or EXT2 alone. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)."},{"id":"ENSMUSP00000101913","abundance":2.01,"rank":8446,"name":"Itgal","annotation":"Integrin alpha-L; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (By similarity). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-c [...] "},{"id":"ENSMUSP00000150019","abundance":2.01,"rank":8447,"name":"Olfr1484","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000118368","abundance":2.01,"rank":8448,"name":"Selenoi","annotation":"Ethanolaminephosphotransferase 1; Catalyzes phosphatidylethanolamine biosynthesis from CDP- ethanolamine. It thereby plays a central role in the formation and maintenance of vesicular membranes. Involved in the formation of phosphatidylethanolamine via 'Kennedy' pathway (By similarity)."},{"id":"ENSMUSP00000106645","abundance":2,"rank":8449,"name":"Muc15","annotation":"Mucin-15."},{"id":"ENSMUSP00000022172","abundance":2,"rank":8450,"name":"Polk","annotation":"DNA polymerase kappa; DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity (By similarity); Belongs to the DNA polymerase type-Y family."},{"id":"ENSMUSP00000023019","abundance":2,"rank":8451,"name":"Trmu","annotation":"Mitochondrial tRNA-specific 2-thiouridylase 1; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base."},{"id":"ENSMUSP00000051652","abundance":2,"rank":8452,"name":"C1qtnf2","annotation":"Complement C1q tumor necrosis factor-related protein 2; Involved in the regulation of lipid metabolism in adipose tissue and liver."},{"id":"ENSMUSP00000026027","abundance":2,"rank":8453,"name":"Taf5","annotation":"Transcription initiation factor TFIID subunit 5; TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TA [...] "},{"id":"ENSMUSP00000028985","abundance":2,"rank":8454,"name":"Bpifa1","annotation":"BPI fold-containing family A member 1; Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (By similarity). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway s [...] "},{"id":"ENSMUSP00000029459","abundance":2,"rank":8455,"name":"Gdap2","annotation":"Ganglioside-induced differentiation-associated protein 2; Belongs to the GDAP2 family."},{"id":"ENSMUSP00000022099","abundance":2,"rank":8456,"name":"Lpcat1","annotation":"Lysophosphatidylcholine acyltransferase 1; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent. Mediates the conversion of 1-acyl-sn-glycero-3- phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl- CoAs, and 1-myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size (By similarity)."},{"id":"ENSMUSP00000022009","abundance":2,"rank":8457,"name":"Cetn3","annotation":"Centrin-3; Plays a fundamental role in microtubule-organizing center structure and function; Belongs to the centrin family."},{"id":"ENSMUSP00000057893","abundance":2,"rank":8458,"name":"Otulin","annotation":"Ubiquitin thioesterase otulin; Deubiquitinase that specifically removes linear ('Met-1'- linked) polyubiquitin chains to substrates and acts as a regulator of angiogenesis and innate immune response. Required during angiogenesis, craniofacial and neuronal development by regulating the canonical Wnt signaling together with the LUBAC complex. Acts as a negative regulator of NF-kappa-B by regulating the activity of the LUBAC complex (By similarity). OTULIN function is mainly restricted to homeostasis of the LUBAC complex: acts by removing 'Met-1'-linked autoubiquitination of the LUBAC com [...] "},{"id":"ENSMUSP00000080717","abundance":2,"rank":8459,"name":"Chil1","annotation":"Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling  [...] "},{"id":"ENSMUSP00000066705","abundance":2,"rank":8460,"name":"Smim10l2a","annotation":"Protein Smim10l2a."},{"id":"ENSMUSP00000075441","abundance":2,"rank":8461,"name":"Zcrb1","annotation":"Zinc finger CCHC-type and RNA-binding motif-containing protein 1."},{"id":"ENSMUSP00000126854","abundance":2,"rank":8462,"name":"Zfp219","annotation":"Zinc finger protein 219; Transcriptional regulator. Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3'. Binds to the HMGN1 promoter and may repress HMGN1 expression (By similarity). Regulates SNCA expression in primary cortical neurons (By similarity). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9. Plays a role in chondrocyte differentiation ; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000151050","abundance":2,"rank":8463,"name":"Olfr402","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000025965","abundance":2,"rank":8464,"name":"Hells","annotation":"Lymphocyte-specific helicase; Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis."},{"id":"ENSMUSP00000157144","abundance":2,"rank":8465,"name":"Ttc39c","annotation":"Tetratricopeptide repeat protein 39C; Belongs to the TTC39 family."},{"id":"ENSMUSP00000113152","abundance":2,"rank":8466,"name":"Tafa1","annotation":"Chemokine-like protein TAFA-1; Regulatory factor which is ligand for GPR1 and is involved in the modulation of neural stem-cell proliferation and differentiation."},{"id":"ENSMUSP00000009392","abundance":2,"rank":8467,"name":"Ascl2","annotation":"Achaete-scute homolog 2; AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system."},{"id":"ENSMUSP00000098957","abundance":2,"rank":8468,"name":"Gm29609","annotation":"Predicted gene 29609."},{"id":"ENSMUSP00000022176","abundance":2,"rank":8469,"name":"Hmgcr","annotation":"3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family."},{"id":"ENSMUSP00000054526","abundance":2,"rank":8470,"name":"Clca3a1","annotation":"Calcium-activated chloride channel regulator 3A-1; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner."},{"id":"ENSMUSP00000032421","abundance":2,"rank":8471,"name":"St8sia1","annotation":"Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid."},{"id":"ENSMUSP00000044577","abundance":1.99,"rank":8472,"name":"Tbc1d1","annotation":"TBC1 domain family member 1; May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells."},{"id":"ENSMUSP00000061185","abundance":1.99,"rank":8473,"name":"Crh","annotation":"Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile."},{"id":"ENSMUSP00000022586","abundance":1.99,"rank":8474,"name":"Nufip1","annotation":"Nuclear fragile X mental retardation-interacting protein 1; Binds RNA."},{"id":"ENSMUSP00000054330","abundance":1.99,"rank":8475,"name":"Ankrd34b","annotation":"Ankyrin repeat domain-containing protein 34B; Belongs to the ANKRD34 family."},{"id":"ENSMUSP00000033070","abundance":1.99,"rank":8476,"name":"Kat8","annotation":"Histone acetyltransferase KAT8; Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'. Belongs to the MYST (SAS/MOZ) family."},{"id":"ENSMUSP00000040828","abundance":1.99,"rank":8477,"name":"Mospd3","annotation":"Motile sperm domain-containing protein 3."},{"id":"ENSMUSP00000016553","abundance":1.99,"rank":8478,"name":"Nkap","annotation":"NF-kappa-B-activating protein; Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF- kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity)."},{"id":"ENSMUSP00000051216","abundance":1.99,"rank":8479,"name":"Styxl1","annotation":"Serine/threonine/tyrosine-interacting-like 1."},{"id":"ENSMUSP00000050395","abundance":1.99,"rank":8480,"name":"Pus10","annotation":"Putative tRNA pseudouridine synthase Pus10; Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (By similarity)."},{"id":"ENSMUSP00000114921","abundance":1.99,"rank":8481,"name":"Lrrc14","annotation":"Leucine-rich repeat-containing protein 14; Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB."},{"id":"ENSMUSP00000057651","abundance":1.99,"rank":8482,"name":"Zscan22","annotation":"Zinc finger and SCAN domain-containing 22."},{"id":"ENSMUSP00000110093","abundance":1.99,"rank":8483,"name":"Maea","annotation":"E3 ubiquitin-protein transferase MAEA; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast enucleat [...] "},{"id":"ENSMUSP00000021957","abundance":1.99,"rank":8484,"name":"Fam193b","annotation":"Protein FAM193B; Belongs to the FAM193 family."},{"id":"ENSMUSP00000093794","abundance":1.99,"rank":8485,"name":"Cstdc5","annotation":"Cystatin domain-containing 5."},{"id":"ENSMUSP00000021438","abundance":1.99,"rank":8486,"name":"Nova1","annotation":"RNA-binding protein Nova-1; Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion. It binds specifically to the sequence UCAUY. Most likely acts to activate the inclusion of exon E3A in the glycine receptor alpha-2 chain and of exon E9 in gamma-aminobutyric-acid receptor gamma- 2 subunit via a distal downstream UCAU-rich intronic splicing enhancer."},{"id":"ENSMUSP00000066734","abundance":1.99,"rank":8487,"name":"Epha6","annotation":"Ephrin type-A receptor 6; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)."},{"id":"ENSMUSP00000103432","abundance":1.99,"rank":8488,"name":"Trim59","annotation":"Tripartite motif-containing protein 59; May serve as a multifunctional regulator for innate immune signaling pathways; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000021302","abundance":1.99,"rank":8489,"name":"Higd1b","annotation":"HIG1 domain family member 1B."},{"id":"ENSMUSP00000136471","abundance":1.98,"rank":8490,"name":"Phospho2","annotation":"Pyridoxal phosphate phosphatase PHOSPHO2; Phosphatase that has high activity toward pyridoxal 5'- phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate (By similarity)."},{"id":"ENSMUSP00000153831","abundance":1.98,"rank":8491,"name":"Olfr1177-ps","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000039546","abundance":1.98,"rank":8492,"name":"Tasp1","annotation":"Threonine aspartase subunit alpha; Protease involved in KMT2A/MLL1 processing and, consequently, in the correct expression of the early HOXA gene cluster."},{"id":"ENSMUSP00000006762","abundance":1.98,"rank":8493,"name":"Snai3","annotation":"Zinc finger protein SNAI3; Seems to inhibit myoblast differentiation. Transcriptional repressor of E-box-dependent transactivation of downstream myogenic bHLHs genes. Binds preferentially to the canonical E-box sequences 5'- CAGGTG-3' and 5'-CACCTG-3'."},{"id":"ENSMUSP00000095783","abundance":1.98,"rank":8494,"name":"Pm20d2","annotation":"Peptidase M20 domain-containing protein 2."},{"id":"ENSMUSP00000051481","abundance":1.98,"rank":8495,"name":"Neurl1b","annotation":"E3 ubiquitin-protein ligase NEURL1B; E3 ubiquitin-protein ligase involved in regulation of the Notch pathway through influencing the stability and activity of several Notch ligands."},{"id":"ENSMUSP00000131625","abundance":1.98,"rank":8496,"name":"Kcnj1","annotation":"ATP-sensitive inward rectifier potassium channel 1; In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal A [...] "},{"id":"ENSMUSP00000035562","abundance":1.98,"rank":8497,"name":"Slfn2","annotation":"Schlafen family member 2."},{"id":"ENSMUSP00000105136","abundance":1.98,"rank":8498,"name":"Tcf20","annotation":"Transcription factor 20; Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator."},{"id":"ENSMUSP00000038610","abundance":1.98,"rank":8499,"name":"Taf4","annotation":"TATA-box-binding protein-associated factor 4."},{"id":"ENSMUSP00000034227","abundance":1.98,"rank":8500,"name":"Pllp","annotation":"Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity)."},{"id":"ENSMUSP00000024887","abundance":1.97,"rank":8501,"name":"Ndufaf7","annotation":"Protein arginine methyltransferase NDUFAF7, mitochondrial; Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Acts by mediating symmetric dimethylation of 'Arg-118' of NDUFS2 after it assembles into the complex I, stabilizing the early intermediate complex; Belongs to the NDUFAF7 family."},{"id":"ENSMUSP00000034017","abundance":1.97,"rank":8502,"name":"Klhl2","annotation":"Kelch-like protein 2; Promotes growth of cell projections in oligodendrocyte precursors. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Component of a cullin- RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Plays a role in the reorganization of the actin cytoskeleton."},{"id":"ENSMUSP00000028314","abundance":1.97,"rank":8503,"name":"Nmi","annotation":"N-myc-interactor; May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription (By similarity). Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5 (By similarity)."},{"id":"ENSMUSP00000039452","abundance":1.97,"rank":8504,"name":"Tnn","annotation":"Tenascin-N; Extracellular matrix protein that seems to be a ligand for ITGA8:ITGB1, ITGAV:ITGB1 and ITGA4:ITGB1 (By similarity). Involved in neurite outgrowth and cell migration in hippocampal explants. During endochondral bone formation, inhibits proliferation and differentiation of proteoblasts mediated by canonical WNT signaling. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells. Belongs to the tenasc [...] "},{"id":"ENSMUSP00000059033","abundance":1.97,"rank":8505,"name":"Hip1","annotation":"Huntingtin-interacting protein 1; Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)- mediated transcription (By similarity). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (By similarity). Binds 3-phosphoinositides (via ENTH domain) (By similarity). May act through the ENTH domain to promote cell survival by stabilizing receptor  [...] "},{"id":"ENSMUSP00000025601","abundance":1.97,"rank":8506,"name":"Lpxn","annotation":"Leupaxin; Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin- induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling."},{"id":"ENSMUSP00000009777","abundance":1.97,"rank":8507,"name":"G0s2","annotation":"G0/G1 switch protein 2; Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers."},{"id":"ENSMUSP00000030284","abundance":1.97,"rank":8508,"name":"Rnf11","annotation":"RING finger protein 11; Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys- 63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys- 48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, lea [...] "},{"id":"ENSMUSP00000022701","abundance":1.97,"rank":8509,"name":"Rb1","annotation":"Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransfer [...] "},{"id":"ENSMUSP00000040072","abundance":1.97,"rank":8510,"name":"Sobp","annotation":"Sine oculis-binding protein homolog; Implicated in development of the cochlea."},{"id":"ENSMUSP00000039580","abundance":1.97,"rank":8511,"name":"Ptpn23","annotation":"Tyrosine-protein phosphatase non-receptor type 23; Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily."},{"id":"ENSMUSP00000035754","abundance":1.97,"rank":8512,"name":"Zic5","annotation":"Zinc finger protein ZIC 5; Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA. Belongs to the GLI C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000023165","abundance":1.97,"rank":8513,"name":"Crebbp","annotation":"Histone lysine acetyltransferase CREBBP; Acetylates histones, giving a specific tag for transcriptional activation (By similarity). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes (By similarity). Acts as a coactivator of ALX1 (By similarity). Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers (By simila [...] "},{"id":"ENSMUSP00000080851","abundance":1.97,"rank":8514,"name":"Chil4","annotation":"Chitinase-like protein 4; Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily."},{"id":"ENSMUSP00000035961","abundance":1.97,"rank":8515,"name":"Tlk1","annotation":"Serine/threonine-protein kinase tousled-like 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly (By similarity). Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10' (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family."},{"id":"ENSMUSP00000031281","abundance":1.97,"rank":8516,"name":"Antxr2","annotation":"Anthrax toxin receptor 2; Necessary for cellular interactions with laminin and the extracellular matrix; Belongs to the ATR family."},{"id":"ENSMUSP00000046243","abundance":1.97,"rank":8517,"name":"Stx11","annotation":"Syntaxin-11; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network."},{"id":"ENSMUSP00000022511","abundance":1.96,"rank":8518,"name":"Zmym2","annotation":"Zinc finger MYM-type protein 2; May function as a transcription factor."},{"id":"ENSMUSP00000037173","abundance":1.96,"rank":8519,"name":"Tyw1","annotation":"S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)."},{"id":"ENSMUSP00000029754","abundance":1.96,"rank":8520,"name":"Hormad1","annotation":"HORMA domain-containing protein 1; Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process b [...] "},{"id":"ENSMUSP00000106436","abundance":1.96,"rank":8521,"name":"Erich1","annotation":"Glutamate-rich 1."},{"id":"ENSMUSP00000061737","abundance":1.96,"rank":8522,"name":"Fastkd3","annotation":"FAST kinase domain-containing protein 3, mitochondrial; Required for normal mitochondrial respiration. Increases steady-state levels and half-lives of a subset of mature mitochondrial mRNAs MT-ND2, MT-ND3, MT-CYTB, MT-CO2, and MT-ATP8/6. Promotes MT-CO1 mRNA translation and increases mitochondrial complex IV assembly and activity."},{"id":"ENSMUSP00000020949","abundance":1.96,"rank":8523,"name":"Map2k6","annotation":"Dual specificity mitogen-activated protein kinase kinase 6; Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 i [...] "},{"id":"ENSMUSP00000125416","abundance":1.96,"rank":8524,"name":"Zfp316","annotation":"Zinc finger protein 316; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000009679","abundance":1.96,"rank":8525,"name":"Rnmt","annotation":"mRNA cap guanine-N7 methyltransferase; Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'- terminal GpppC."},{"id":"ENSMUSP00000002291","abundance":1.96,"rank":8526,"name":"Paxip1","annotation":"PAX-interacting protein 1; Involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes such as the MLL2/MLL3 complex. Plays a role in early development. In DNA damage response is required for cell survival after ionizing radiation. In vitro shown to be involved in the homologous recombination mechanism for the repair of double-strand breaks (DSBs). Its localization to DNA damage foci requires Rnf8 and Ube2n. Recruits Tp53bp1 to DNA damage foci and, at least in particular repair processes, effective DNA damage response appears to r [...] "},{"id":"ENSMUSP00000030375","abundance":1.96,"rank":8527,"name":"Exo5","annotation":"Exonuclease V; Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'- directionality activity (By similarity)."},{"id":"ENSMUSP00000124476","abundance":1.96,"rank":8528,"name":"Tcerg1l","annotation":"Transcription elongation regulator 1-like protein."},{"id":"ENSMUSP00000060110","abundance":1.96,"rank":8529,"name":"Kcnj9","annotation":"G protein-activated inward rectifier potassium channel 3; This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium."},{"id":"ENSMUSP00000021920","abundance":1.96,"rank":8530,"name":"Sptlc1","annotation":"Serine palmitoyltransferase 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1- SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates. The SPTLC1-SPTLC2-SPTSSB complex displays a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme has the ability to use a broader range of acyl-CoAs (By  [...] "},{"id":"ENSMUSP00000013302","abundance":1.96,"rank":8531,"name":"4933405L10Rik","annotation":"Uncharacterized protein C16orf86 homolog."},{"id":"ENSMUSP00000068690","abundance":1.95,"rank":8532,"name":"Lclat1","annotation":"Lysocardiolipin acyltransferase 1; Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol- 3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn- glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl  [...] "},{"id":"ENSMUSP00000023600","abundance":1.95,"rank":8533,"name":"Robo1","annotation":"Roundabout homolog 1; Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its intera [...] "},{"id":"ENSMUSP00000031288","abundance":1.95,"rank":8534,"name":"Tfip11","annotation":"Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] "},{"id":"ENSMUSP00000149463","abundance":1.95,"rank":8535,"name":"Senp8","annotation":"Sentrin-specific protease 8; Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53."},{"id":"ENSMUSP00000100679","abundance":1.95,"rank":8536,"name":"Gm11596","annotation":"Predicted gene 11596."},{"id":"ENSMUSP00000057865","abundance":1.95,"rank":8537,"name":"Tmem198","annotation":"Transmembrane protein 198; Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity (By similarity)."},{"id":"ENSMUSP00000070131","abundance":1.95,"rank":8538,"name":"Cd8b1","annotation":"T-cell surface glycoprotein CD8 beta chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src [...] "},{"id":"ENSMUSP00000034303","abundance":1.95,"rank":8539,"name":"Mphosph6","annotation":"M-phase phosphoprotein 6; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and plays a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D. Belongs to the MPP6 family."},{"id":"ENSMUSP00000031895","abundance":1.95,"rank":8540,"name":"Casp2","annotation":"Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity)."},{"id":"ENSMUSP00000018842","abundance":1.95,"rank":8541,"name":"Lhx1","annotation":"LIM/homeobox protein Lhx1; Potential transcription factor. May play a role in early mesoderm formation and later in lateral mesoderm differentiation and neurogenesis."},{"id":"ENSMUSP00000099862","abundance":1.95,"rank":8542,"name":"Tek","annotation":"Angiopoietin-1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angi [...] "},{"id":"ENSMUSP00000146183","abundance":1.95,"rank":8543,"name":"Olfr465-ps1","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000033958","abundance":1.95,"rank":8544,"name":"Adam3","annotation":"A disintegrin and metallopeptidase domain 3; Involved in fertilization by controlling sperm migration into oviduct."},{"id":"ENSMUSP00000035826","abundance":1.95,"rank":8545,"name":"Haus1","annotation":"HAUS augmin-like complex subunit 1; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex."},{"id":"ENSMUSP00000095344","abundance":1.95,"rank":8546,"name":"Pusl1","annotation":"tRNA pseudouridine synthase-like 1; Belongs to the tRNA pseudouridine synthase TruA family."},{"id":"ENSMUSP00000110989","abundance":1.95,"rank":8547,"name":"Zfp182","annotation":"Zinc finger protein 182; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000135703","abundance":1.95,"rank":8548,"name":"Prox1","annotation":"Prospero homeobox protein 1; Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of [...] "},{"id":"ENSMUSP00000059391","abundance":1.95,"rank":8549,"name":"Shisa2","annotation":"Protein shisa-2 homolog; Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. Belongs to the shisa family."},{"id":"ENSMUSP00000021968","abundance":1.95,"rank":8550,"name":"Pitx1","annotation":"Pituitary homeobox 1; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Can independently activate and synergize with PIT-1 on pituitary-specific target gene promoters, thus may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs. Can activate pituitary transcription of the proopiomelanocortin gene."},{"id":"ENSMUSP00000021268","abundance":1.94,"rank":8551,"name":"Aloxe3","annotation":"Hydroperoxide isomerase ALOXE3; Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty [...] "},{"id":"ENSMUSP00000081531","abundance":1.94,"rank":8552,"name":"Dock1","annotation":"Dedicator of cytokinesis protein 1; Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1."},{"id":"ENSMUSP00000022806","abundance":1.94,"rank":8553,"name":"Bcl2l2","annotation":"Bcl-2-like protein 2; Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. Belongs to the Bcl-2 family."},{"id":"ENSMUSP00000107741","abundance":1.94,"rank":8554,"name":"Cabp1","annotation":"Calcium-binding protein 1; Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium- dependent facilitation of voltage-dependent P/Q-type calcium channels (By similarity). Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but has an opposite effect on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inh [...] "},{"id":"ENSMUSP00000022338","abundance":1.94,"rank":8555,"name":"Rgr","annotation":"RPE-retinal G protein-coupled receptor; Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism (By similarity)."},{"id":"ENSMUSP00000074902","abundance":1.94,"rank":8556,"name":"Cr1l","annotation":"Complement component receptor 1-like protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay- accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Plays a crucial role in early embryonic development by maintaining fetomaternal tolerance. Also acts as a costimulatory factor for T-cells which favors IL-4 secretion."},{"id":"ENSMUSP00000082754","abundance":1.94,"rank":8557,"name":"Usp12","annotation":"Ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2."},{"id":"ENSMUSP00000108865","abundance":1.94,"rank":8558,"name":"Crbn","annotation":"Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium- activated potassium channels in brain regions involved in memory and learning via its interaction wit [...] "},{"id":"ENSMUSP00000075821","abundance":1.94,"rank":8559,"name":"Speer2","annotation":"Spermatogenesis-associated glutamate (E)-rich protein 2."},{"id":"ENSMUSP00000050469","abundance":1.94,"rank":8560,"name":"C1ql1","annotation":"C1q-related factor; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses."},{"id":"ENSMUSP00000064637","abundance":1.94,"rank":8561,"name":"Zfp24","annotation":"Zinc finger protein 24; Transcription factor required for myelination of differentiated oligodendrocytes. Required for the conversion of oligodendrocytes from the premyelinating to the myelinating state. In the developing central nervous system (CNS), involved in the maintenance in the progenitor stage by promoting the cell cycle. Specifically binds to the 5'-TCAT-3' DNA sequence. Has transcription repressor activity in vitro; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000036915","abundance":1.93,"rank":8562,"name":"Vps18","annotation":"Vacuolar protein sorting-associated protein 18 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late  [...] "},{"id":"ENSMUSP00000127212","abundance":1.93,"rank":8563,"name":"C530008M17Rik","annotation":"Capping protein inhibiting regulator of actin dynamics; Involved in epithelial cell integrity by acting on the dynamics of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin (By similarity)."},{"id":"ENSMUSP00000049715","abundance":1.93,"rank":8564,"name":"Hsfy2","annotation":"Heat shock transcription factor, Y-linked 2."},{"id":"ENSMUSP00000139509","abundance":1.93,"rank":8565,"name":"Cep57l1","annotation":"Centrosomal protein CEP57L1; Centrosomal protein which may be required for microtubule attachment to centrosomes."},{"id":"ENSMUSP00000063108","abundance":1.93,"rank":8566,"name":"Myoz3","annotation":"Myozenin-3; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis."},{"id":"ENSMUSP00000009814","abundance":1.93,"rank":8567,"name":"Tex11","annotation":"Testis-expressed protein 11; Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers; Belongs to the SPO22 family."},{"id":"ENSMUSP00000033506","abundance":1.93,"rank":8568,"name":"Wdr13","annotation":"WD repeat-containing protein 13."},{"id":"ENSMUSP00000085285","abundance":1.93,"rank":8569,"name":"Zfp64","annotation":"Zinc finger protein 64; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000153240","abundance":1.93,"rank":8570,"name":"Trim38","annotation":"Tripartite motif-containing 38."},{"id":"ENSMUSP00000132361","abundance":1.93,"rank":8571,"name":"Zfp710","annotation":"Zinc finger protein 710; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000124204","abundance":1.93,"rank":8572,"name":"Dlx6","annotation":"Homeobox protein DLX-6; Belongs to the distal-less homeobox family."},{"id":"ENSMUSP00000044714","abundance":1.93,"rank":8573,"name":"Cip2a","annotation":"Protein CIP2A; Promotes anchorage-independent cell growth and tumor formation."},{"id":"ENSMUSP00000023291","abundance":1.93,"rank":8574,"name":"Mapk8ip2","annotation":"C-Jun-amino-terminal kinase-interacting protein 2; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells (By similarity)."},{"id":"ENSMUSP00000063201","abundance":1.93,"rank":8575,"name":"Taf8","annotation":"Transcription initiation factor TFIID subunit 8; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo; Bel [...] "},{"id":"ENSMUSP00000131753","abundance":1.93,"rank":8576,"name":"Mmel1","annotation":"Membrane metallo-endopeptidase-like 1, soluble form; Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond. Belongs to the peptidase M13 family."},{"id":"ENSMUSP00000030245","abundance":1.93,"rank":8577,"name":"4921539E11Rik","annotation":"Uncharacterized protein C1orf141 homolog."},{"id":"ENSMUSP00000093969","abundance":1.93,"rank":8578,"name":"Arid2","annotation":"AT-rich interactive domain-containing protein 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Belongs to the RFX family."},{"id":"ENSMUSP00000154442","abundance":1.93,"rank":8579,"name":"Vmn1r42","annotation":"Vomeronasal type-1 receptor 42; Putative pheromone receptor implicated in the regulation of social and reproductive behavior."},{"id":"ENSMUSP00000068402","abundance":1.93,"rank":8580,"name":"C1ql4","annotation":"Complement C1q-like protein 4; May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. May inhibit adipocyte differentiation at an early stage of the process."},{"id":"ENSMUSP00000104932","abundance":1.93,"rank":8581,"name":"Shank3","annotation":"SH3 and multiple ankyrin repeat domains protein 3; Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex  [...] "},{"id":"ENSMUSP00000111103","abundance":1.93,"rank":8582,"name":"Met","annotation":"Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] "},{"id":"ENSMUSP00000083018","abundance":1.93,"rank":8583,"name":"Zfp157","annotation":"Zinc finger protein 157."},{"id":"ENSMUSP00000104128","abundance":1.93,"rank":8584,"name":"Ceacam13","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 13."},{"id":"ENSMUSP00000017821","abundance":1.93,"rank":8585,"name":"Wsb1","annotation":"WD repeat and SOCS box-containing protein 1; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation (By similarity)."},{"id":"ENSMUSP00000070718","abundance":1.92,"rank":8586,"name":"Wfdc15a","annotation":"WAP four-disulfide core domain protein 15A; Antibacterial protein."},{"id":"ENSMUSP00000136647","abundance":1.92,"rank":8587,"name":"Olfr56","annotation":"Olfactory receptor 56; Odorant receptor. Activated by (+) and (-)-limonene."},{"id":"ENSMUSP00000048457","abundance":1.92,"rank":8588,"name":"Surf6","annotation":"Surfeit locus protein 6; Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly. Belongs to the SURF6 family."},{"id":"ENSMUSP00000111405","abundance":1.92,"rank":8589,"name":"Foxp3","annotation":"Forkhead box protein P3, C-terminally processed; Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The s [...] "},{"id":"ENSMUSP00000149663","abundance":1.92,"rank":8590,"name":"Olfr509","annotation":"Olfactory receptor MOR267-14."},{"id":"ENSMUSP00000109886","abundance":1.92,"rank":8591,"name":"Cdk15","annotation":"Cyclin-dependent kinase 15; Serine/threonine-protein kinase that acts like an antiapoptotic protein that counters TRAIL/TNFSF10-induced apoptosis by inducing phosphorylation of BIRC5 at 'Thr-34'."},{"id":"ENSMUSP00000048053","abundance":1.92,"rank":8592,"name":"Wfs1","annotation":"Wolframin; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store."},{"id":"ENSMUSP00000086285","abundance":1.92,"rank":8593,"name":"Tmcc1","annotation":"Transmembrane and coiled-coil domains protein 1; Endoplasmic reticulum membrane protein that promotes endoplasmic reticulum-associated endosome fission. Localizes to contact sites between the endoplasmic reticulum and endosomes and acts by promoting recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Belongs to the TEX28 family."},{"id":"ENSMUSP00000040162","abundance":1.92,"rank":8594,"name":"Reep4","annotation":"Receptor expression-enhancing protein 4; Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity); Belongs to the DP1 family."},{"id":"ENSMUSP00000022239","abundance":1.92,"rank":8595,"name":"Parp8","annotation":"Protein mono-ADP-ribosyltransferase PARP8; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins."},{"id":"ENSMUSP00000070339","abundance":1.92,"rank":8596,"name":"Jmy","annotation":"Junction-mediating and -regulatory protein; Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin poly [...] "},{"id":"ENSMUSP00000118182","abundance":1.92,"rank":8597,"name":"Slx1b","annotation":"Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products."},{"id":"ENSMUSP00000046196","abundance":1.92,"rank":8598,"name":"Srxn1","annotation":"Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family."},{"id":"ENSMUSP00000029879","abundance":1.92,"rank":8599,"name":"Nbn","annotation":"Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] "},{"id":"ENSMUSP00000039263","abundance":1.92,"rank":8600,"name":"Grifin","annotation":"Grifin."},{"id":"ENSMUSP00000148146","abundance":1.92,"rank":8601,"name":"Gm45785","annotation":"Predicted gene 45785."},{"id":"ENSMUSP00000085170","abundance":1.92,"rank":8602,"name":"Uvssa","annotation":"UV-stimulated scaffold protein A; Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to  [...] "},{"id":"ENSMUSP00000040198","abundance":1.91,"rank":8603,"name":"Slc25a23","annotation":"Calcium-binding mitochondrial carrier protein SCaMC-3; Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria. Acts as a regulator of mitochondrial calcium uptake via interaction with MCU and MICU1."},{"id":"ENSMUSP00000158759","abundance":1.91,"rank":8604,"name":"Gm21586","annotation":"Predicted gene, 21586."},{"id":"ENSMUSP00000111571","abundance":1.91,"rank":8605,"name":"LOC100862220","annotation":"Predicted gene, 20878."},{"id":"ENSMUSP00000116356","abundance":1.91,"rank":8606,"name":"Gm20878","annotation":"Predicted gene, 20878."},{"id":"ENSMUSP00000158629","abundance":1.91,"rank":8607,"name":"Gm21953","annotation":"Predicted gene, 21953."},{"id":"ENSMUSP00000126340","abundance":1.91,"rank":8608,"name":"Fignl1","annotation":"Fidgetin-like protein 1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. May regulate osteoblast proliferation and differentiation. May play a role in the control of male meiosis dynamic."},{"id":"ENSMUSP00000144143","abundance":1.91,"rank":8609,"name":"Olfr1118","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000046604","abundance":1.91,"rank":8610,"name":"Dpp9","annotation":"Dipeptidyl peptidase 9; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Belongs to the peptidase S9B family. DPPIV subfamily."},{"id":"ENSMUSP00000106772","abundance":1.91,"rank":8611,"name":"Dtx2","annotation":"Probable E3 ubiquitin-protein ligase DTX2; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity)."},{"id":"ENSMUSP00000044627","abundance":1.91,"rank":8612,"name":"Dtx3","annotation":"Probable E3 ubiquitin-protein ligase DTX3; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity."},{"id":"ENSMUSP00000101412","abundance":1.91,"rank":8613,"name":"Spen","annotation":"Msx2-interacting protein; May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways, such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivat [...] "},{"id":"ENSMUSP00000035490","abundance":1.91,"rank":8614,"name":"Kif15","annotation":"Kinesin-like protein KIF15; Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily."},{"id":"ENSMUSP00000113385","abundance":1.91,"rank":8615,"name":"Cdc7","annotation":"Cell division cycle 7-related protein kinase; Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3."},{"id":"ENSMUSP00000077378","abundance":1.91,"rank":8616,"name":"D130040H23Rik","annotation":"RIKEN cDNA D130040H23 gene."},{"id":"ENSMUSP00000076367","abundance":1.91,"rank":8617,"name":"Gjc3","annotation":"Gap junction gamma-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Gamma-type subfamily."},{"id":"ENSMUSP00000030841","abundance":1.91,"rank":8618,"name":"Klhl7","annotation":"Kelch-like protein 7; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination (By similarity)."},{"id":"ENSMUSP00000019944","abundance":1.91,"rank":8619,"name":"Adat2","annotation":"tRNA-specific adenosine deaminase 2; Probably participates in deamination of adenosine-34 to inosine in many tRNAs."},{"id":"ENSMUSP00000066779","abundance":1.91,"rank":8620,"name":"Slc6a13","annotation":"Sodium- and chloride-dependent GABA transporter 2; Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. In the liver, may be the major contributor for GABA uptake. Also involved in beta-alanine transport; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily."},{"id":"ENSMUSP00000025482","abundance":1.91,"rank":8621,"name":"Atp8b1","annotation":"Phospholipid-transporting ATPase IC; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in asymmetric distribution of phospholipids in the canicular membrane. Plays a role in bile salt homeostasis. In cooperation with ABCB4 may be involved  [...] "},{"id":"ENSMUSP00000015449","abundance":1.91,"rank":8622,"name":"Sash1","annotation":"SAM and SH3 domain-containing protein 1; Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis."},{"id":"ENSMUSP00000080641","abundance":1.91,"rank":8623,"name":"Med9","annotation":"Mediator of RNA polymerase II transcription subunit 9; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000112965","abundance":1.91,"rank":8624,"name":"Asb15","annotation":"Ankyrin repeat and SOCS box protein 15; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins."},{"id":"ENSMUSP00000015587","abundance":1.91,"rank":8625,"name":"Gzmn","annotation":"Granzyme N; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000047128","abundance":1.91,"rank":8626,"name":"Glb1l2","annotation":"Beta-galactosidase-1-like protein 2; Belongs to the glycosyl hydrolase 35 family."},{"id":"ENSMUSP00000092138","abundance":1.9,"rank":8627,"name":"Arhgap24","annotation":"Rho GTPase-activating protein 24; Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamel [...] "},{"id":"ENSMUSP00000098752","abundance":1.9,"rank":8628,"name":"Klhl5","annotation":"Klhl5 protein."},{"id":"ENSMUSP00000021016","abundance":1.9,"rank":8629,"name":"Hnf1b","annotation":"Hepatocyte nuclear factor 1-beta; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'; Belongs to the HNF1 homeobox family."},{"id":"ENSMUSP00000102750","abundance":1.9,"rank":8630,"name":"Atxn7l3","annotation":"Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] "},{"id":"ENSMUSP00000072389","abundance":1.9,"rank":8631,"name":"Gps2","annotation":"G protein pathway suppressor 2; Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'- linked ubiquitination. In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context. Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histo [...] "},{"id":"ENSMUSP00000058990","abundance":1.9,"rank":8632,"name":"Cog7","annotation":"Conserved oligomeric Golgi complex subunit 7; Required for normal Golgi function."},{"id":"ENSMUSP00000076393","abundance":1.9,"rank":8633,"name":"Dsg1a","annotation":"Desmoglein-1-alpha; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion."},{"id":"ENSMUSP00000101907","abundance":1.9,"rank":8634,"name":"Zfp688","annotation":"Zinc finger protein 688."},{"id":"ENSMUSP00000087997","abundance":1.9,"rank":8635,"name":"Gcc1","annotation":"GRIP and coiled-coil domain-containing protein 1; Probably involved in maintaining Golgi structure."},{"id":"ENSMUSP00000032477","abundance":1.9,"rank":8636,"name":"Necap1","annotation":"Adaptin ear-binding coat-associated protein 1; Involved in endocytosis."},{"id":"ENSMUSP00000111022","abundance":1.9,"rank":8637,"name":"Tmem243","annotation":"Transmembrane protein 243, mitochondrial."},{"id":"ENSMUSP00000055297","abundance":1.9,"rank":8638,"name":"P4ha3","annotation":"Prolyl 4-hydroxylase subunit alpha-3; Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins; Belongs to the P4HA family."},{"id":"ENSMUSP00000010267","abundance":1.9,"rank":8639,"name":"Slc47a1","annotation":"Multidrug and toxin extrusion protein 1; Solute transporter for tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin. Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent). Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid. Responsible for the secretion of cationic drugs across the brush border membran [...] "},{"id":"ENSMUSP00000077219","abundance":1.9,"rank":8640,"name":"Tank","annotation":"TRAF family member-associated NF-kappa-B activator; Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1- mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation  [...] "},{"id":"ENSMUSP00000023225","abundance":1.9,"rank":8641,"name":"Grina","annotation":"Protein lifeguard 1; Potential apoptotic regulator; Belongs to the BI1 family. LFG subfamily."},{"id":"ENSMUSP00000131938","abundance":1.9,"rank":8642,"name":"Fcgr3","annotation":"Low affinity immunoglobulin gamma Fc region receptor III; Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor which binds to IgG1, IgG2a and IgG2b. Mediates neutrophil activation by IgG complexes redundantly with Fcgr4."},{"id":"ENSMUSP00000033282","abundance":1.9,"rank":8643,"name":"Bccip","annotation":"BRCA2 and CDKN1A-interacting protein; During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity)."},{"id":"ENSMUSP00000030944","abundance":1.9,"rank":8644,"name":"Ccnl2","annotation":"Cyclin-L2; Involved in pre-mRNA splicing. May induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors."},{"id":"ENSMUSP00000020023","abundance":1.9,"rank":8645,"name":"Reep3","annotation":"Receptor expression-enhancing protein 3; Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes (By similarity); Belongs to the DP1 family."},{"id":"ENSMUSP00000050646","abundance":1.9,"rank":8646,"name":"4930539E08Rik","annotation":"Protein BNIP5."},{"id":"ENSMUSP00000005507","abundance":1.9,"rank":8647,"name":"Mlxipl","annotation":"Carbohydrate-responsive element-binding protein; Transcriptional repressor. Binds to the canonical and non- canonical E box sequences 5'-CACGTG-3'."},{"id":"ENSMUSP00000058354","abundance":1.9,"rank":8648,"name":"Msx1","annotation":"Homeobox protein MSX-1; Acts as a transcriptional repressor. May play a role in limb- pattern formation. Acts in cranofacial development and specifically in odontogenesis; Belongs to the Msh homeobox family."},{"id":"ENSMUSP00000109855","abundance":1.89,"rank":8649,"name":"Ajm1","annotation":"Apical junction component 1 homolog; May be involved in the control of adherens junction integrity."},{"id":"ENSMUSP00000058020","abundance":1.89,"rank":8650,"name":"Onecut1","annotation":"Hepatocyte nuclear factor 6; Transcriptional activator. Binds the consensus sequence 5'- DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Stimulates the expression of Onecut3 in the developing endoderm."},{"id":"ENSMUSP00000033419","abundance":1.89,"rank":8651,"name":"Dock11","annotation":"Dedicator of cytokinesis protein 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology. Facilitates filopodia formation through the activation of CDC42. Belongs to the DOCK family."},{"id":"ENSMUSP00000023750","abundance":1.89,"rank":8652,"name":"Faim2","annotation":"Protein lifeguard 2; Antiapoptotic protein which protects cells uniquely from Fas- induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. Plays a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development. Belongs to the BI1 family. LFG subfamily."},{"id":"ENSMUSP00000011623","abundance":1.89,"rank":8653,"name":"Dennd1c","annotation":"DENN domain-containing protein 1C; Guanine nucleotide exchange factor (GEF) which may activate RAB8A, RAB13 and RAB35. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form."},{"id":"ENSMUSP00000011895","abundance":1.89,"rank":8654,"name":"Sptbn4","annotation":"Spectrin beta chain; Belongs to the spectrin family."},{"id":"ENSMUSP00000113998","abundance":1.89,"rank":8655,"name":"Hipk1","annotation":"Homeodomain-interacting protein kinase 1; Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by  [...] "},{"id":"ENSMUSP00000106489","abundance":1.89,"rank":8656,"name":"Adap1","annotation":"ArfGAP with dual PH domains 1."},{"id":"ENSMUSP00000094115","abundance":1.89,"rank":8657,"name":"Mroh1","annotation":"Maestro heat-like repeat family member 1."},{"id":"ENSMUSP00000058969","abundance":1.89,"rank":8658,"name":"2310079G19Rik","annotation":"RIKEN cDNA 2310079G19 gene."},{"id":"ENSMUSP00000010434","abundance":1.89,"rank":8659,"name":"AI597479","annotation":"Ashwin."},{"id":"ENSMUSP00000058762","abundance":1.89,"rank":8660,"name":"Gpr135","annotation":"G-protein coupled receptor 135; Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity)."},{"id":"ENSMUSP00000151666","abundance":1.89,"rank":8661,"name":"Olfr1344","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000015157","abundance":1.89,"rank":8662,"name":"Trappc2l","annotation":"Trafficking protein particle complex subunit 2-like protein; May play a role in vesicular transport from endoplasmic reticulum to Golgi."},{"id":"ENSMUSP00000042173","abundance":1.89,"rank":8663,"name":"Ppp1r26","annotation":"Protein phosphatase 1 regulatory subunit 26; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes. May positively regulate cell proliferation."},{"id":"ENSMUSP00000071899","abundance":1.89,"rank":8664,"name":"Adtrp","annotation":"Androgen-dependent TFPI-regulating protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (By similarity). Shows a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (By similarity). Regulates the expression and the cell-associated anticoagulant activity of the inhibitor TFPI in endothelial cells (in vitro) (By similarity). Belongs to the AIG1 family."},{"id":"ENSMUSP00000143626","abundance":1.89,"rank":8665,"name":"Adgrl2","annotation":"Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis."},{"id":"ENSMUSP00000136545","abundance":1.89,"rank":8666,"name":"March1","annotation":"E3 ubiquitin-protein ligase MARCHF1; E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system."},{"id":"ENSMUSP00000043742","abundance":1.89,"rank":8667,"name":"Tmed8","annotation":"Protein TMED8."},{"id":"ENSMUSP00000074771","abundance":1.89,"rank":8668,"name":"Ppargc1b","annotation":"Peroxisome proliferator-activated receptor gamma coactivator 1-beta; Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty  [...] "},{"id":"ENSMUSP00000011302","abundance":1.89,"rank":8669,"name":"Brf1","annotation":"Transcription factor IIIB 90 kDa subunit; General activator of RNA polymerase which utilizes different TFIIIB complexes at structurally distinct promoters."},{"id":"ENSMUSP00000115860","abundance":1.88,"rank":8670,"name":"Knstrn","annotation":"Small kinetochore-associated protein; Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments. Required for kinetochore oscillations and dynamics of microtubule plus- ends during live cell mitosis, possibly by forming a link between spindle microtubule [...] "},{"id":"ENSMUSP00000086411","abundance":1.88,"rank":8671,"name":"Fndc3a","annotation":"Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis."},{"id":"ENSMUSP00000075773","abundance":1.88,"rank":8672,"name":"Ggt6","annotation":"Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family."},{"id":"ENSMUSP00000102512","abundance":1.88,"rank":8673,"name":"Cxcr2","annotation":"C-X-C chemokine receptor type 2; Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2."},{"id":"ENSMUSP00000129613","abundance":1.88,"rank":8674,"name":"Trnp1","annotation":"TMF-regulated nuclear protein 1; DNA-binding factor that regulates the expression of a subset of genes and plays a key role in tangential, radial, and lateral expansion of the brain neocortex. Regulates neural stem cells proliferation and the production of intermediate neural progenitors and basal radial glial cells affecting the process of cerebral cortex gyrification. May control the proliferation rate of cells by regulating their progression through key cell-cycle transition points."},{"id":"ENSMUSP00000046517","abundance":1.88,"rank":8675,"name":"Cdo1","annotation":"Cysteine dioxygenase type 1; Belongs to the cysteine dioxygenase family."},{"id":"ENSMUSP00000078808","abundance":1.88,"rank":8676,"name":"Scamp4","annotation":"Secretory carrier-associated membrane protein 4; Probably involved in membrane protein trafficking. Belongs to the SCAMP family."},{"id":"ENSMUSP00000133054","abundance":1.88,"rank":8677,"name":"Spats2l","annotation":"SPATS2-like protein; Belongs to the SPATS2 family."},{"id":"ENSMUSP00000150243","abundance":1.88,"rank":8678,"name":"Olfr1450","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000114624","abundance":1.88,"rank":8679,"name":"Tex30","annotation":"Testis-expressed protein 30."},{"id":"ENSMUSP00000059574","abundance":1.88,"rank":8680,"name":"Clec4g","annotation":"C-type lectin domain family 4 member G; Binds mannose, N-acetylglucosamine (GlcNAc) and fucose, but not galactose, in a Ca(2+)-dependent manner."},{"id":"ENSMUSP00000020316","abundance":1.88,"rank":8681,"name":"Tbk1","annotation":"Serine/threonine-protein kinase TBK1; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X (By similarity). This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB (By similarity). In order to establish such [...] "},{"id":"ENSMUSP00000090293","abundance":1.88,"rank":8682,"name":"Soga3","annotation":"Protein SOGA3."},{"id":"ENSMUSP00000103048","abundance":1.87,"rank":8683,"name":"Aen","annotation":"Apoptosis-enhancing nuclease; Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single- stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity)."},{"id":"ENSMUSP00000149215","abundance":1.87,"rank":8684,"name":"Olfr1305","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000000327","abundance":1.87,"rank":8685,"name":"Clec10a","annotation":"C-type lectin domain family 10 member A; Recognizes terminal galactose and N-acetylgalactosamine units. May participate in the interaction between tumoricidal macrophages and tumor cells. Plays a role in the recruitment of inflammatory monocytes to adipose tissue in diet-induced obesity."},{"id":"ENSMUSP00000085633","abundance":1.87,"rank":8686,"name":"Chpf2","annotation":"Hexosyltransferase."},{"id":"ENSMUSP00000001812","abundance":1.87,"rank":8687,"name":"Smo","annotation":"Smoothened homolog; G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia. Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation."},{"id":"ENSMUSP00000108157","abundance":1.87,"rank":8688,"name":"Zranb3","annotation":"DNA annealing helicase and endonuclease ZRANB3; DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D- loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. [...] "},{"id":"ENSMUSP00000056001","abundance":1.87,"rank":8689,"name":"Irgm2","annotation":"Immunity-related GTPase family M member 2."},{"id":"ENSMUSP00000057263","abundance":1.87,"rank":8690,"name":"Bri3","annotation":"Brain protein I3; Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver (By similarity)."},{"id":"ENSMUSP00000050465","abundance":1.87,"rank":8691,"name":"4933430I17Rik","annotation":"RIKEN cDNA 4933430I17 gene."},{"id":"ENSMUSP00000123698","abundance":1.87,"rank":8692,"name":"Eapp","annotation":"E2F-associated phosphoprotein; May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression (By similarity)."},{"id":"ENSMUSP00000133474","abundance":1.87,"rank":8693,"name":"Pear1","annotation":"Platelet endothelial aggregation receptor 1; When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells; Belongs to the MEGF family."},{"id":"ENSMUSP00000030384","abundance":1.87,"rank":8694,"name":"Edn2","annotation":"Endothelin-2; Vasoconstrictor; Belongs to the endothelin/sarafotoxin family."},{"id":"ENSMUSP00000020543","abundance":1.87,"rank":8695,"name":"Cpeb4","annotation":"Cytoplasmic polyadenylation element-binding protein 4; Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism (By similarity). Regulates activation of unfolded protein response (UPR) in the process of adaptation to ER stress in liver, by maintaining translation of CPE- regulated mRNAs in conditions in which global protein synthesis is inhibited. Required for  [...] "},{"id":"ENSMUSP00000096806","abundance":1.86,"rank":8696,"name":"Foxs1","annotation":"Forkhead box protein S1; Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature."},{"id":"ENSMUSP00000120525","abundance":1.86,"rank":8697,"name":"Irf9","annotation":"Interferon regulatory factor 9; Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state."},{"id":"ENSMUSP00000026045","abundance":1.86,"rank":8698,"name":"Col17a1","annotation":"120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane."},{"id":"ENSMUSP00000026357","abundance":1.86,"rank":8699,"name":"Jph3","annotation":"Junctophilin-3; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory."},{"id":"ENSMUSP00000124293","abundance":1.86,"rank":8700,"name":"Rnf6","annotation":"E3 ubiquitin-protein ligase RNF6; E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys- 27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator."},{"id":"ENSMUSP00000095901","abundance":1.86,"rank":8701,"name":"Alg8","annotation":"Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol before it is transferred to the nascent peptide (By similarity). Required for PKD1/Polycystin-1 maturation and localization to the plasma membrane of the primary cilia ; Belongs to the ALG6/ALG8 glucosyltransferase family."},{"id":"ENSMUSP00000034961","abundance":1.86,"rank":8702,"name":"Igdcc3","annotation":"Immunoglobulin superfamily DCC subclass member 3; Belongs to the immunoglobulin superfamily. DCC family."},{"id":"ENSMUSP00000077650","abundance":1.86,"rank":8703,"name":"Xlr5a","annotation":"X-linked lymphocyte-regulated 5A."},{"id":"ENSMUSP00000110164","abundance":1.86,"rank":8704,"name":"Xlr5b","annotation":"X-linked lymphocyte-regulated 5B."},{"id":"ENSMUSP00000106934","abundance":1.86,"rank":8705,"name":"Dgkz","annotation":"Diacylglycerol kinase zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes. Activates PIP5K1A activity via generation of phosphatidic acid."},{"id":"ENSMUSP00000135437","abundance":1.86,"rank":8706,"name":"Mrgpra3","annotation":"Mas-related G-protein coupled receptor member A3; Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity). Activated by the antimalarial drug chloroquine. Mediates chloroquine-induced itch, in a histamine-independent manner."},{"id":"ENSMUSP00000079231","abundance":1.86,"rank":8707,"name":"Rest","annotation":"RE1-silencing transcription factor; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Trans [...] "},{"id":"ENSMUSP00000064819","abundance":1.86,"rank":8708,"name":"Slfn5","annotation":"Schlafen family member 5; May have a role in hematopoietic cell differentiation."},{"id":"ENSMUSP00000022857","abundance":1.86,"rank":8709,"name":"Ttc23l","annotation":"Tetratricopeptide repeat protein 23-like."},{"id":"ENSMUSP00000023260","abundance":1.86,"rank":8710,"name":"Lypd2","annotation":"Ly6/PLAUR domain-containing protein 2."},{"id":"ENSMUSP00000018012","abundance":1.86,"rank":8711,"name":"Sgk2","annotation":"Serine/threonine-protein kinase Sgk2; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase."},{"id":"ENSMUSP00000096204","abundance":1.86,"rank":8712,"name":"Spint2","annotation":"Kunitz-type protease inhibitor 2; Inhibitor of HGF activator."},{"id":"ENSMUSP00000041599","abundance":1.86,"rank":8713,"name":"Helq","annotation":"Helicase POLQ-like; Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links; Belongs to the helicase family. SKI2 subfamily."},{"id":"ENSMUSP00000022985","abundance":1.86,"rank":8714,"name":"Klhl38","annotation":"Kelch-like protein 38."},{"id":"ENSMUSP00000010940","abundance":1.86,"rank":8715,"name":"Asz1","annotation":"Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the p [...] "},{"id":"ENSMUSP00000020513","abundance":1.86,"rank":8716,"name":"Papolg","annotation":"Poly(A) polymerase gamma; Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA; Belongs to the poly(A) polymerase family."},{"id":"ENSMUSP00000052639","abundance":1.86,"rank":8717,"name":"Stxbp6","annotation":"Syntaxin-binding protein 6; Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis."},{"id":"ENSMUSP00000143044","abundance":1.85,"rank":8718,"name":"Ankle2","annotation":"Ankyrin repeat and LEM domain-containing protein 2; Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex (By similarity). Belongs to the ANKLE2 family."},{"id":"ENSMUSP00000046686","abundance":1.85,"rank":8719,"name":"Hhat","annotation":"Protein-cysteine N-palmitoyltransferase HHAT; Catalyzes N-terminal palmitoylation of SHH; which is required for SHH signaling during limb development. May bind GTP."},{"id":"ENSMUSP00000097770","abundance":1.85,"rank":8720,"name":"Alg1","annotation":"Chitobiosyldiphosphodolichol beta-mannosyltransferase; Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity)."},{"id":"ENSMUSP00000101636","abundance":1.85,"rank":8721,"name":"Adgrb2","annotation":"Adhesion G protein-coupled receptor B2; Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ. Involved in angiogenesis inhibition."},{"id":"ENSMUSP00000054389","abundance":1.85,"rank":8722,"name":"Ccn3","annotation":"CCN family member 3; Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival. Acts by binding to integrins or membrane receptors such as NOTCH1. Essential regulator of hematopoietic stem and progenitor cell function. Inhibits myogenic differentiation through the activation of Notch-signaling pathway. Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling. Ligand of integrins ITGAV:ITGB3 and ITGA5 [...] "},{"id":"ENSMUSP00000143789","abundance":1.85,"rank":8723,"name":"Ints1","annotation":"Integrator complex subunit 1; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex."},{"id":"ENSMUSP00000157710","abundance":1.85,"rank":8724,"name":"Gramd3","annotation":"GRAM domain-containing protein 2B."},{"id":"ENSMUSP00000005114","abundance":1.85,"rank":8725,"name":"Fxyd4","annotation":"FXYD domain-containing ion transport regulator 4."},{"id":"ENSMUSP00000015124","abundance":1.85,"rank":8726,"name":"Tsen15","annotation":"tRNA-splicing endonuclease subunit Sen15; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA bo [...] "},{"id":"ENSMUSP00000047655","abundance":1.85,"rank":8727,"name":"Pof1b","annotation":"Protein POF1B; Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development (By similarity)."},{"id":"ENSMUSP00000036524","abundance":1.85,"rank":8728,"name":"Fam91a1","annotation":"Protein FAM91A1; As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1."},{"id":"ENSMUSP00000070991","abundance":1.85,"rank":8729,"name":"Dbr1","annotation":"Lariat debranching enzyme; Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity)."},{"id":"ENSMUSP00000088196","abundance":1.85,"rank":8730,"name":"Syt6","annotation":"Synaptotagmin-6; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm ; Belongs to the synaptotagmin family."},{"id":"ENSMUSP00000105581","abundance":1.85,"rank":8731,"name":"Cstl1","annotation":"Cystatin-like 1; Belongs to the cystatin family."},{"id":"ENSMUSP00000037929","abundance":1.85,"rank":8732,"name":"Mpv17l2","annotation":"Mpv17-like protein 2; Required for the assembly and stability of the mitochondrial ribosome (By similarity). Is a positive regulator of mitochondrial protein synthesis (By similarity)."},{"id":"ENSMUSP00000041622","abundance":1.85,"rank":8733,"name":"Cercam","annotation":"Inactive glycosyltransferase 25 family member 3; Probable cell adhesion protein involved in leukocyte transmigration across the blood-brain barrier. Does not express any beta-galactosyltransferase activity in vitro. Belongs to the glycosyltransferase 25 family."},{"id":"ENSMUSP00000107651","abundance":1.85,"rank":8734,"name":"Klra10","annotation":"Killer cell lectin-like receptor subfamily A, member 10."},{"id":"ENSMUSP00000047672","abundance":1.85,"rank":8735,"name":"Setd1a","annotation":"Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression; Belongs to the class V-like SAM-binding methyltransferase superfamily."},{"id":"ENSMUSP00000151689","abundance":1.85,"rank":8736,"name":"Hbs1l","annotation":"HBS1-like protein."},{"id":"ENSMUSP00000099928","abundance":1.84,"rank":8737,"name":"Rel","annotation":"Proto-oncogene c-Rel; Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferen [...] "},{"id":"ENSMUSP00000108429","abundance":1.84,"rank":8738,"name":"Gtdc1","annotation":"Glycosyltransferase-like domain-containing protein 1."},{"id":"ENSMUSP00000034654","abundance":1.84,"rank":8739,"name":"Mfrp","annotation":"Membrane frizzled-related protein; May play a role in eye development."},{"id":"ENSMUSP00000029344","abundance":1.84,"rank":8740,"name":"Mfsd1","annotation":"Major facilitator superfamily domain-containing protein 1."},{"id":"ENSMUSP00000027449","abundance":1.84,"rank":8741,"name":"Nppc","annotation":"C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3."},{"id":"ENSMUSP00000113185","abundance":1.84,"rank":8742,"name":"Slc26a1","annotation":"Sulfate anion transporter 1; Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate (By similarity). Belongs to the SLC26A/SulP transporter (TC 2.A.53) family."},{"id":"ENSMUSP00000023214","abundance":1.84,"rank":8743,"name":"Dgat1","annotation":"Diacylglycerol O-acyltransferase 1; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders."},{"id":"ENSMUSP00000109609","abundance":1.84,"rank":8744,"name":"5430427O19Rik","annotation":"Protein CXorf21 homolog; Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes. May be involved in endolysosomal-dependent immune responses."},{"id":"ENSMUSP00000126958","abundance":1.84,"rank":8745,"name":"Cnmd","annotation":"Leukocyte cell-derived chemotaxin 1; Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development (By similarity). Inhibits in vitro tube formation and mobilization of endothelial cells (By similarity). Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization."},{"id":"ENSMUSP00000051085","abundance":1.84,"rank":8746,"name":"Sstr5","annotation":"Somatostatin receptor type 5; Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization."},{"id":"ENSMUSP00000032749","abundance":1.84,"rank":8747,"name":"Vps33b","annotation":"Vacuolar protein sorting-associated protein 33B; May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Mediates phagolysosomal fusion in macrophages. Proposed to be involved in endosomal maturation implicating in part VIPAS39 (By similarity). In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependentrecycling pathway and in the maintenance of the apical-basolateral polarity. Seems to be involved in the sorting of specific cargos from the trans-Golgi netw [...] "},{"id":"ENSMUSP00000071188","abundance":1.83,"rank":8748,"name":"Arl9","annotation":"ADP-ribosylation factor-like 9."},{"id":"ENSMUSP00000026390","abundance":1.83,"rank":8749,"name":"Rabgef1","annotation":"Rab5 GDP/GTP exchange factor; Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A (By similarity). Can act as a ubiquitin ligase (By similarity)."},{"id":"ENSMUSP00000106382","abundance":1.83,"rank":8750,"name":"Defa41","annotation":"Defensin, alpha, 41."},{"id":"ENSMUSP00000093655","abundance":1.83,"rank":8751,"name":"Vmn1r212","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000056401","abundance":1.83,"rank":8752,"name":"Sall2","annotation":"Sal-like protein 2; Probable transcription factor that plays a role in eye development before, during, and after optic fissure closure. Belongs to the sal C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000056977","abundance":1.83,"rank":8753,"name":"Ajuba","annotation":"LIM domain-containing protein ajuba; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an importa [...] "},{"id":"ENSMUSP00000001854","abundance":1.83,"rank":8754,"name":"Slc7a10","annotation":"Asc-type amino acid transporter 1; Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse; Belongs to the amino acid-polyamine-organocation (APC) superfamily."},{"id":"ENSMUSP00000038757","abundance":1.83,"rank":8755,"name":"Esyt3","annotation":"Extended synaptotagmin-3; Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Belongs to the extended synaptotagmin family."},{"id":"ENSMUSP00000042204","abundance":1.83,"rank":8756,"name":"Med30","annotation":"Mediator of RNA polymerase II transcription subunit 30; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000081954","abundance":1.83,"rank":8757,"name":"Dpy19l4","annotation":"Probable C-mannosyltransferase DPY19L4; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins."},{"id":"ENSMUSP00000157132","abundance":1.83,"rank":8758,"name":"Colec12","annotation":"Collectin-12; Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells (By similarity). Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifica [...] "},{"id":"ENSMUSP00000085528","abundance":1.83,"rank":8759,"name":"Obp1b","annotation":"Odorant-binding protein 1b; Binds the chemical odorant 2-isobutyl-3-methoxypyrazine."},{"id":"ENSMUSP00000026558","abundance":1.83,"rank":8760,"name":"Ric8a","annotation":"Synembryn-A; Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)- alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity); Belongs to the synemb [...] "},{"id":"ENSMUSP00000091882","abundance":1.83,"rank":8761,"name":"Cdc25a","annotation":"M-phase inducer phosphatase 1; Tyrosine protein phosphatase which functions as a dosage- dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro (By similarity). Phosphorylation by PIM1 leads to an increase in phosphatase activity (By similarity)."},{"id":"ENSMUSP00000154703","abundance":1.83,"rank":8762,"name":"Olfr680-ps1","annotation":"Olfactory receptor 680, pseudogene 1."},{"id":"ENSMUSP00000122199","abundance":1.82,"rank":8763,"name":"Usp3","annotation":"Ubiquitin carboxyl-terminal hydrolase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (By similarity)."},{"id":"ENSMUSP00000084400","abundance":1.82,"rank":8764,"name":"Trim40","annotation":"Tripartite motif-containing protein 40; May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity (By similarity); Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000022228","abundance":1.82,"rank":8765,"name":"Cwc27","annotation":"Spliceosome-associated protein CWC27 homolog; As part of the spliceosome, plays a role in pre-mRNA splicing. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity; Belongs to the cyclophilin-type PPIase family."},{"id":"ENSMUSP00000143769","abundance":1.82,"rank":8766,"name":"Usp29","annotation":"Ubiquitin carboxyl-terminal hydrolase 29; Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000116865","abundance":1.82,"rank":8767,"name":"Dnajc21","annotation":"DnaJ homolog subfamily C member 21; May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA."},{"id":"ENSMUSP00000023525","abundance":1.82,"rank":8768,"name":"Gtf2e1","annotation":"General transcription factor IIE subunit 1; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase."},{"id":"ENSMUSP00000066325","abundance":1.82,"rank":8769,"name":"Rab3gap2","annotation":"Rab3 GTPase-activating protein non-catalytic subunit; Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters [...] "},{"id":"ENSMUSP00000048042","abundance":1.82,"rank":8770,"name":"Lrrc20","annotation":"Leucine-rich repeat-containing protein 20."},{"id":"ENSMUSP00000048340","abundance":1.82,"rank":8771,"name":"Ythdc2","annotation":"3'-5' RNA helicase YTHDC2; 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNA [...] "},{"id":"ENSMUSP00000035043","abundance":1.82,"rank":8772,"name":"Armc8","annotation":"Armadillo repeat-containing protein 8; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1."},{"id":"ENSMUSP00000041800","abundance":1.82,"rank":8773,"name":"E130309D02Rik","annotation":"Uncharacterized protein C7orf26 homolog."},{"id":"ENSMUSP00000083393","abundance":1.82,"rank":8774,"name":"Anapc5","annotation":"Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC5 family."},{"id":"ENSMUSP00000097667","abundance":1.82,"rank":8775,"name":"Rprm","annotation":"Protein reprimo; May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex. Belongs to the reprimo family."},{"id":"ENSMUSP00000028859","abundance":1.82,"rank":8776,"name":"Acoxl","annotation":"Acyl-coenzyme A oxidase-like protein; Belongs to the acyl-CoA oxidase family."},{"id":"ENSMUSP00000150439","abundance":1.82,"rank":8777,"name":"Olfr497","annotation":"Olfactory receptor 497; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000020485","abundance":1.82,"rank":8778,"name":"Glt8d2","annotation":"Glycosyltransferase 8 domain-containing protein 2."},{"id":"ENSMUSP00000048450","abundance":1.82,"rank":8779,"name":"Rbm34","annotation":"RNA-binding protein 34."},{"id":"ENSMUSP00000036923","abundance":1.82,"rank":8780,"name":"Nostrin","annotation":"Nostrin; Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane."},{"id":"ENSMUSP00000030730","abundance":1.82,"rank":8781,"name":"Trnau1ap","annotation":"tRNA selenocysteine 1-associated protein 1; Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis."},{"id":"ENSMUSP00000005820","abundance":1.82,"rank":8782,"name":"Nr1i3","annotation":"Nuclear receptor subfamily 1 group I member 3; Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity); Belongs to the nuclear hormone receptor family. NR1 subfamily."},{"id":"ENSMUSP00000029573","abundance":1.81,"rank":8783,"name":"Lrrc39","annotation":"Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart."},{"id":"ENSMUSP00000100062","abundance":1.81,"rank":8784,"name":"Ccnc","annotation":"Cyclin-C; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin- dependent kinase CDK8 that phosphoryla [...] "},{"id":"ENSMUSP00000154261","abundance":1.81,"rank":8785,"name":"Ndor1-3","annotation":"NADPH-dependent diflavin oxidoreductase 1."},{"id":"ENSMUSP00000083680","abundance":1.81,"rank":8786,"name":"Olfr834","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000107884","abundance":1.81,"rank":8787,"name":"Bmx","annotation":"Cytoplasmic tyrosine-protein kinase BMX; Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of in [...] "},{"id":"ENSMUSP00000062171","abundance":1.81,"rank":8788,"name":"Flrt2","annotation":"Leucine-rich repeat transmembrane protein FLRT2; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signal [...] "},{"id":"ENSMUSP00000070109","abundance":1.81,"rank":8789,"name":"Ggcx","annotation":"Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide."},{"id":"ENSMUSP00000022212","abundance":1.81,"rank":8790,"name":"Plk2","annotation":"Serine/threonine-protein kinase PLK2; Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 an [...] "},{"id":"ENSMUSP00000037255","abundance":1.81,"rank":8791,"name":"Grm1","annotation":"Metabotropic glutamate receptor 1; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina."},{"id":"ENSMUSP00000147037","abundance":1.81,"rank":8792,"name":"Samd4b","annotation":"Protein Smaug homolog 2; Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A (By similarity); Belongs to the SMAUG family."},{"id":"ENSMUSP00000125729","abundance":1.81,"rank":8793,"name":"Usf1","annotation":"Upstream stimulatory factor 1; Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters."},{"id":"ENSMUSP00000041742","abundance":1.81,"rank":8794,"name":"3110001I22Rik","annotation":"RIKEN cDNA 3110001I22 gene."},{"id":"ENSMUSP00000096209","abundance":1.81,"rank":8795,"name":"Ggn","annotation":"Gametogenetin; May be involved in spermatogenesis."},{"id":"ENSMUSP00000048721","abundance":1.81,"rank":8796,"name":"Spaca5","annotation":"Sperm acrosome-associated protein 5; Belongs to the glycosyl hydrolase 22 family."},{"id":"ENSMUSP00000030127","abundance":1.81,"rank":8797,"name":"Tmem38b","annotation":"Trimeric intracellular cation channel type B; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores."},{"id":"ENSMUSP00000003035","abundance":1.81,"rank":8798,"name":"Disp1","annotation":"Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion. Belongs to the dispatched family."},{"id":"ENSMUSP00000100680","abundance":1.81,"rank":8799,"name":"Krtap4-9","annotation":"Keratin associated protein 4-9."},{"id":"ENSMUSP00000100777","abundance":1.81,"rank":8800,"name":"Ifna6","annotation":"Interferon alpha-6; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase."},{"id":"ENSMUSP00000030852","abundance":1.8,"rank":8801,"name":"Rint1","annotation":"RAD50-interacting protein 1; Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control (By similarity). Belongs to the RINT1 family."},{"id":"ENSMUSP00000024829","abundance":1.8,"rank":8802,"name":"Abcg1","annotation":"ATP-binding cassette sub-family G member 1; Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta- hydroxycholesterol and this transport is coupled to hydrlysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (By similarity)."},{"id":"ENSMUSP00000021187","abundance":1.8,"rank":8803,"name":"Dhrs13","annotation":"Dehydrogenase/reductase SDR family member 13; Putative oxidoreductase."},{"id":"ENSMUSP00000152730","abundance":1.8,"rank":8804,"name":"Trim27","annotation":"Zinc finger protein RFP; E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'- linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity indepen [...] "},{"id":"ENSMUSP00000084464","abundance":1.8,"rank":8805,"name":"Cnga1","annotation":"cGMP-gated cation channel alpha-1; Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential."},{"id":"ENSMUSP00000135946","abundance":1.8,"rank":8806,"name":"Rpl36-ps4","annotation":"Ribosomal protein L36, pseudogene 4."},{"id":"ENSMUSP00000077438","abundance":1.8,"rank":8807,"name":"Cacnb4","annotation":"Voltage-dependent L-type calcium channel subunit beta-4; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting."},{"id":"ENSMUSP00000062593","abundance":1.8,"rank":8808,"name":"Ing1","annotation":"Inhibitor of growth protein 1; Isoform 1 inhibits p53-dependent transcriptional activation and may function as an oncoprotein. Isoform 2 acts as a negative growth regulator by cooperating with p53 in transcriptional activation of p53- responsive genes and may act as a tumor suppressor. Belongs to the ING family."},{"id":"ENSMUSP00000028554","abundance":1.8,"rank":8809,"name":"Lpcat4","annotation":"Lysophospholipid acyltransferase LPCAT4; Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, 1-alkenyl- lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoA [...] "},{"id":"ENSMUSP00000048643","abundance":1.8,"rank":8810,"name":"Tigar","annotation":"Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell [...] "},{"id":"ENSMUSP00000023363","abundance":1.8,"rank":8811,"name":"Rrn3","annotation":"RNA polymerase I-specific transcription initiation factor RRN3; Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction; Belongs to the RRN3 family."},{"id":"ENSMUSP00000067611","abundance":1.8,"rank":8812,"name":"Slc25a40","annotation":"Solute carrier family 25 member 40; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000039029","abundance":1.8,"rank":8813,"name":"Slc7a6os","annotation":"Probable RNA polymerase II nuclear localization protein SLC7A6OS; Directs RNA polymerase II nuclear import; Belongs to the IWR1/SLC7A6OS family."},{"id":"ENSMUSP00000064211","abundance":1.8,"rank":8814,"name":"1700024B05Rik","annotation":"RIKEN cDNA 1700024B05 gene."},{"id":"ENSMUSP00000097795","abundance":1.8,"rank":8815,"name":"Mefv","annotation":"Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation. However, it [...] "},{"id":"ENSMUSP00000098707","abundance":1.8,"rank":8816,"name":"Nlrp3","annotation":"NACHT, LRR and PYD domains-containing protein 3; As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion. The active cytokines a [...] "},{"id":"ENSMUSP00000036945","abundance":1.79,"rank":8817,"name":"Themis2","annotation":"Protein THEMIS2; May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Belongs to the themis family."},{"id":"ENSMUSP00000104077","abundance":1.79,"rank":8818,"name":"Zfp93","annotation":"Zinc finger protein 235; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000105249","abundance":1.79,"rank":8819,"name":"Apobec3","annotation":"DNA dC->dU-editing enzyme APOBEC-3; DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons."},{"id":"ENSMUSP00000109833","abundance":1.79,"rank":8820,"name":"Jam2","annotation":"Junctional adhesion molecule B; Junctional adhesion protein that mediates heterotypic cell- cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Teth [...] "},{"id":"ENSMUSP00000128848","abundance":1.79,"rank":8821,"name":"Utf1","annotation":"Undifferentiated embryonic cell transcription factor 1; Acts as a transcriptional coactivator of ATF2."},{"id":"ENSMUSP00000061153","abundance":1.79,"rank":8822,"name":"Ghsr","annotation":"Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine) (By similarity)."},{"id":"ENSMUSP00000029106","abundance":1.79,"rank":8823,"name":"Zbtb46","annotation":"Zinc finger and BTB domain-containing protein 46; Functions as a transcriptional repressor for PRDM1."},{"id":"ENSMUSP00000115871","abundance":1.79,"rank":8824,"name":"Slain2","annotation":"SLAIN motif-containing protein 2; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Required for normal structure of the microtubule cytoskeleton during interphase. Belongs to the SLAIN motif-containing family."},{"id":"ENSMUSP00000016907","abundance":1.79,"rank":8825,"name":"Scube1","annotation":"Signal peptide, CUB and EGF-like domain-containing protein 1; Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology."},{"id":"ENSMUSP00000024832","abundance":1.79,"rank":8826,"name":"Rsph1","annotation":"Radial spoke head 1 homolog; The specific expression during male germ cell development and its characteristic localization suggest that it may play an important role in male meiosis. It is necessary for proper building of the axonemal central pair and radial spokes (By similarity)."},{"id":"ENSMUSP00000063510","abundance":1.79,"rank":8827,"name":"Dram2","annotation":"DNA damage-regulated autophagy modulator protein 2; Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1."},{"id":"ENSMUSP00000014321","abundance":1.79,"rank":8828,"name":"Tvp23b","annotation":"Golgi apparatus membrane protein TVP23 homolog B."},{"id":"ENSMUSP00000074707","abundance":1.79,"rank":8829,"name":"Cdyl","annotation":"Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing  [...] "},{"id":"ENSMUSP00000053056","abundance":1.79,"rank":8830,"name":"Ormdl3","annotation":"ORM1-like protein 3; Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity)."},{"id":"ENSMUSP00000046539","abundance":1.79,"rank":8831,"name":"Camk4","annotation":"Calcium/calmodulin-dependent protein kinase type IV; Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the productio [...] "},{"id":"ENSMUSP00000061997","abundance":1.79,"rank":8832,"name":"Mfsd5","annotation":"Molybdate-anion transporter; Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum; Belongs to the major facilitator superfamily."},{"id":"ENSMUSP00000045998","abundance":1.79,"rank":8833,"name":"Ube3c","annotation":"Ubiquitin-protein ligase E3C; E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys- 48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo."},{"id":"ENSMUSP00000112170","abundance":1.79,"rank":8834,"name":"Mphosph8","annotation":"M-phase phosphoprotein 8; Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites;  [...] "},{"id":"ENSMUSP00000139026","abundance":1.79,"rank":8835,"name":"Tex9","annotation":"Testis-expressed protein 9."},{"id":"ENSMUSP00000034731","abundance":1.79,"rank":8836,"name":"Lipc","annotation":"Hepatic triacylglycerol lipase; Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin."},{"id":"ENSMUSP00000036265","abundance":1.79,"rank":8837,"name":"Skiv2l","annotation":"Superkiller viralicidic activity 2-like (S. cerevisiae)."},{"id":"ENSMUSP00000055787","abundance":1.79,"rank":8838,"name":"1700056E22Rik","annotation":"RIKEN cDNA 1700056E22 gene."},{"id":"ENSMUSP00000093622","abundance":1.79,"rank":8839,"name":"Ccnb1ip1","annotation":"E3 ubiquitin-protein ligase CCNB1IP1; Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non- crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels  [...] "},{"id":"ENSMUSP00000130636","abundance":1.78,"rank":8840,"name":"Ranbp9","annotation":"Ran-binding protein 9; May act as scaffolding protein, and as adapter protein to couple membrane receptors to intracellular signaling pathways. Acts as a mediator of cell spreading and actin cytoskeleton rearrangement. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotesto [...] "},{"id":"ENSMUSP00000087947","abundance":1.78,"rank":8841,"name":"Fyb","annotation":"FYN-binding protein 1; Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity). Modulates the expression of IL2. Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2 (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells."},{"id":"ENSMUSP00000102176","abundance":1.78,"rank":8842,"name":"Skint4","annotation":"Selection and upkeep of intraepithelial T-cells protein 4; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus."},{"id":"ENSMUSP00000099334","abundance":1.78,"rank":8843,"name":"Stmn3","annotation":"Stathmin-3; Exhibits microtubule-destabilizing activity, which is antagonized by STAT3."},{"id":"ENSMUSP00000080443","abundance":1.78,"rank":8844,"name":"0610040J01Rik","annotation":"Uncharacterized protein C4orf19 homolog."},{"id":"ENSMUSP00000028814","abundance":1.78,"rank":8845,"name":"Rassf2","annotation":"Ras association domain-containing protein 2; Potential tumor suppressor. Acts as a KRAS-specific effector protein. May promote apoptosis and cell cycle arrest. Stabilizes STK3/MST2 by protecting it from proteasomal degradation (By similarity)."},{"id":"ENSMUSP00000075973","abundance":1.78,"rank":8846,"name":"Psg20","annotation":"Pregnancy-specific glycoprotein 20."},{"id":"ENSMUSP00000099858","abundance":1.78,"rank":8847,"name":"Ggta1","annotation":"N-acetyllactosaminide alpha-1,3-galactosyltransferase; Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid. Preferentially glycosylates proteins, can synthesize galactose-alpha(1,3)-galactose on glycoproteins but cannot synthesize the glycolipid called isoglobotrihexosylceramide or isogloboside 3 (iGb3)."},{"id":"ENSMUSP00000025779","abundance":1.78,"rank":8848,"name":"Cdk2ap2","annotation":"Cyclin-dependent kinase 2-associated protein 2; Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A (By similarity)."},{"id":"ENSMUSP00000148225","abundance":1.78,"rank":8849,"name":"Gm45717","annotation":"Predicted gene 45717."},{"id":"ENSMUSP00000128888","abundance":1.78,"rank":8850,"name":"Tpx2","annotation":"Targeting protein for Xklp2; Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin- alpha, allowing TPX2 to activate [...] "},{"id":"ENSMUSP00000145402","abundance":1.78,"rank":8851,"name":"Rab11fip5","annotation":"Rab11 family-interacting protein 5; Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis."},{"id":"ENSMUSP00000085872","abundance":1.78,"rank":8852,"name":"Magi2","annotation":"Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation (By similarity); Belongs to the MAGUK family."},{"id":"ENSMUSP00000034064","abundance":1.78,"rank":8853,"name":"F11","annotation":"Coagulation factor XIa heavy chain; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX."},{"id":"ENSMUSP00000041883","abundance":1.77,"rank":8854,"name":"Tspan10","annotation":"Tetraspanin-10; Regulates maturation of the transmembrane metalloprotease ADAM10."},{"id":"ENSMUSP00000126674","abundance":1.77,"rank":8855,"name":"Zfp692","annotation":"Zinc finger protein 692; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000126874","abundance":1.77,"rank":8856,"name":"Ccnt1","annotation":"Cyclin-T1; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C- terminal domain) of the large subunit of RNA polymerase II (RNA Pol II)."},{"id":"ENSMUSP00000038739","abundance":1.77,"rank":8857,"name":"Lipt1","annotation":"Lipoyltransferase 1, mitochondrial; Catalyzes the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes; Belongs to the LplA family."},{"id":"ENSMUSP00000102244","abundance":1.77,"rank":8858,"name":"Slc39a11","annotation":"Zinc transporter ZIP11; Functions as a cellular zinc transporter."},{"id":"ENSMUSP00000081880","abundance":1.77,"rank":8859,"name":"Golga4","annotation":"Golgin subfamily A member 4; Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking."},{"id":"ENSMUSP00000056805","abundance":1.77,"rank":8860,"name":"Tmem104","annotation":"Transmembrane protein 104."},{"id":"ENSMUSP00000095253","abundance":1.77,"rank":8861,"name":"Ramp1","annotation":"Receptor activity-modifying protein 1; Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. Belongs to the RAMP family."},{"id":"ENSMUSP00000121023","abundance":1.77,"rank":8862,"name":"Raph1","annotation":"Ras association (RalGDS/AF-6) and pleckstrin homology domains 1."},{"id":"ENSMUSP00000047356","abundance":1.77,"rank":8863,"name":"Igtp","annotation":"Interferon gamma-induced GTPase."},{"id":"ENSMUSP00000032459","abundance":1.77,"rank":8864,"name":"Vgll4","annotation":"Transcription cofactor vestigial-like protein 4; May act as a specific coactivator for the mammalian TEFs. Belongs to the vestigial family."},{"id":"ENSMUSP00000048057","abundance":1.77,"rank":8865,"name":"Inppl1","annotation":"Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling [...] "},{"id":"ENSMUSP00000101496","abundance":1.77,"rank":8866,"name":"Pafah2","annotation":"Platelet-activating factor acetylhydrolase 2, cytoplasmic; Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme (By similarity). Belongs to the serine esterase family."},{"id":"ENSMUSP00000049095","abundance":1.77,"rank":8867,"name":"Ins1","annotation":"Insulin-1 A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver."},{"id":"ENSMUSP00000109804","abundance":1.77,"rank":8868,"name":"Camsap1","annotation":"Calmodulin-regulated spectrin-associated protein 1; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and stabilizes microtubules. Acts on free microtubule minus- ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization. In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymeri [...] "},{"id":"ENSMUSP00000093988","abundance":1.77,"rank":8869,"name":"Slc22a30","annotation":"Solute carrier family 22, member 30."},{"id":"ENSMUSP00000113628","abundance":1.77,"rank":8870,"name":"Tmc8","annotation":"Transmembrane channel-like protein 8; Probable ion channel."},{"id":"ENSMUSP00000015138","abundance":1.77,"rank":8871,"name":"Eln","annotation":"Elastin; Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle."},{"id":"ENSMUSP00000062039","abundance":1.77,"rank":8872,"name":"Ndufaf6","annotation":"NADH dehydrogenase (ubiquinone) complex I, assembly factor 6; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1 (By similarity); Belongs to the NDUFAF6 family."},{"id":"ENSMUSP00000031591","abundance":1.76,"rank":8873,"name":"Lhx5","annotation":"LIM/homeobox protein Lhx5; Plays an essential role in the regulation of neuronal differentiation and migration during development of the central nervous system."},{"id":"ENSMUSP00000138312","abundance":1.76,"rank":8874,"name":"Ppfia1","annotation":"Ppfia1 protein."},{"id":"ENSMUSP00000135676","abundance":1.76,"rank":8875,"name":"Vmn1r23","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000117082","abundance":1.76,"rank":8876,"name":"Dcaf10","annotation":"DDB1- and CUL4-associated factor 10; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF10 family."},{"id":"ENSMUSP00000093605","abundance":1.76,"rank":8877,"name":"Gm5800","annotation":"Predicted gene, EG545047."},{"id":"ENSMUSP00000066969","abundance":1.76,"rank":8878,"name":"Klk15","annotation":"Kallikrein-related-peptidase 15; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000096813","abundance":1.76,"rank":8879,"name":"Zcchc3","annotation":"Zinc finger CCHC domain-containing protein 3; Nucleic acid-binding protein involved in innate immune response to DNA and RNA viruses. Binds DNA and RNA in the cytoplasm and acts by promoting recognition of viral nucleic acids by virus sensors, such as DDX58/RIG-I, IFIH1/MDA5 and CGAS. Acts as a co-sensor for recognition of double-stranded DNA (dsDNA) by cGAS in the cytoplasm, thereby playing a role in innate immune response to cytosolic dsDNA and DNA virus (By similarity). Binds dsDNA and probably acts by promoting sensing of dsDNA by CGAS, leading to enhance CGAS oligomerization and a [...] "},{"id":"ENSMUSP00000081670","abundance":1.76,"rank":8880,"name":"Tbc1d2","annotation":"TBC1 domain family member 2A; Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity)."},{"id":"ENSMUSP00000025562","abundance":1.76,"rank":8881,"name":"Incenp","annotation":"Inner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within th [...] "},{"id":"ENSMUSP00000041199","abundance":1.76,"rank":8882,"name":"Lrrc18","annotation":"Leucine-rich repeat-containing protein 18; May be involved in the regulation of spermatogenesis and sperm maturation."},{"id":"ENSMUSP00000067811","abundance":1.76,"rank":8883,"name":"Lysmd1","annotation":"LysM and putative peptidoglycan-binding domain-containing protein 1."},{"id":"ENSMUSP00000107787","abundance":1.76,"rank":8884,"name":"Tlr7","annotation":"Toll-like receptor 7; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response."},{"id":"ENSMUSP00000014747","abundance":1.76,"rank":8885,"name":"Alx3","annotation":"Homeobox protein aristaless-like 3; Transcriptional regulator with a possible role in patterning of mesoderm during development; Belongs to the paired homeobox family."},{"id":"ENSMUSP00000122080","abundance":1.76,"rank":8886,"name":"Ptgir","annotation":"Prostacyclin receptor; Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000157476","abundance":1.76,"rank":8887,"name":"Scyl1","annotation":"N-terminal kinase-like protein; Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro."},{"id":"ENSMUSP00000030723","abundance":1.76,"rank":8888,"name":"Mtf1","annotation":"Metal regulatory transcription factor 1; Activates the metallothionein I promoter. Binds to the metal responsive element (MRE)."},{"id":"ENSMUSP00000151105","abundance":1.75,"rank":8889,"name":"Olfr1387","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000034644","abundance":1.75,"rank":8890,"name":"Vps11","annotation":"Vacuolar protein sorting-associated protein 11 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late  [...] "},{"id":"ENSMUSP00000054337","abundance":1.75,"rank":8891,"name":"Plpp7","annotation":"Inactive phospholipid phosphatase 7; Plays a role as negative regulator of myoblast differentiation, in part through effects on MTOR signaling. Has no detectable enzymatic activity. Knockdown in myoblasts strongly promotes differentiation, whereas overexpression represses myogenesis."},{"id":"ENSMUSP00000028759","abundance":1.75,"rank":8892,"name":"Ltk","annotation":"Leukocyte tyrosine kinase receptor; Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (By similarity)."},{"id":"ENSMUSP00000050103","abundance":1.75,"rank":8893,"name":"Rnf152","annotation":"E3 ubiquitin-protein ligase RNF152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (By similarity)."},{"id":"ENSMUSP00000055261","abundance":1.75,"rank":8894,"name":"H2bfm","annotation":"H2B histone family, member M; Belongs to the histone H2B family."},{"id":"ENSMUSP00000052170","abundance":1.75,"rank":8895,"name":"Terf2ip","annotation":"Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)- mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology- directed repair ( [...] "},{"id":"ENSMUSP00000088046","abundance":1.75,"rank":8896,"name":"Celsr2","annotation":"Cadherin EGF LAG seven-pass G-type receptor 2; Receptor that may have an important role in cell/cell signaling during nervous system formation."},{"id":"ENSMUSP00000022916","abundance":1.75,"rank":8897,"name":"Lrp12","annotation":"Low-density lipoprotein receptor-related protein 12; Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor (By similarity); Belongs to the LDLR family."},{"id":"ENSMUSP00000045297","abundance":1.75,"rank":8898,"name":"Uvrag","annotation":"UV radiation resistance-associated protein; Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3- phosphate (PtdIns(3)P). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation  [...] "},{"id":"ENSMUSP00000049676","abundance":1.75,"rank":8899,"name":"Slc22a17","annotation":"Solute carrier family 22 member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo- 24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] "},{"id":"ENSMUSP00000082490","abundance":1.75,"rank":8900,"name":"Pih1d1","annotation":"PIH1 domain-containing protein 1; Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (By similarity). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (By similarity). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (By similarity). Positively regulates the assembly and activity of the mTORC1 complex (By similarity)."},{"id":"ENSMUSP00000099580","abundance":1.75,"rank":8901,"name":"Rap1gap2","annotation":"Rap1 GTPase-activating protein 2; GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP- bound state."},{"id":"ENSMUSP00000034464","abundance":1.75,"rank":8902,"name":"2310022B05Rik","annotation":"Uncharacterized protein C1orf198 homolog."},{"id":"ENSMUSP00000039420","abundance":1.75,"rank":8903,"name":"Gtf3c3","annotation":"General transcription factor IIIC, polypeptide 3."},{"id":"ENSMUSP00000066426","abundance":1.75,"rank":8904,"name":"Pfkfb2","annotation":"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; Synthesis and degradation of fructose 2,6-bisphosphate."},{"id":"ENSMUSP00000125315","abundance":1.75,"rank":8905,"name":"Galnt4","annotation":"Polypeptide N-acetylgalactosaminyltransferase 4; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward EA2 peptide substrate and a much lower activity with EPO-T, Muc2, Muc1a, Muc1b."},{"id":"ENSMUSP00000067434","abundance":1.75,"rank":8906,"name":"Ang","annotation":"Angiogenin; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (By similarity)."},{"id":"ENSMUSP00000029665","abundance":1.75,"rank":8907,"name":"Dkk2","annotation":"Dickkopf-related protein 2; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease; Belongs to the dickkopf family."},{"id":"ENSMUSP00000125297","abundance":1.75,"rank":8908,"name":"Riox2","annotation":"Ribosomal oxygenase 2; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39' (By similarity). May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles."},{"id":"ENSMUSP00000031419","abundance":1.75,"rank":8909,"name":"Fam216a","annotation":"Protein FAM216A; Belongs to the FAM216 family."},{"id":"ENSMUSP00000041806","abundance":1.75,"rank":8910,"name":"Neurl2","annotation":"Neuralized-like protein 2; Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma."},{"id":"ENSMUSP00000043370","abundance":1.75,"rank":8911,"name":"Slc25a16","annotation":"Graves disease carrier protein homolog; Required for the accumulation of coenzyme A in the mitochondrial matrix."},{"id":"ENSMUSP00000047541","abundance":1.75,"rank":8912,"name":"Fbxo38","annotation":"F-box only protein 38; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity. Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival. May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without [...] "},{"id":"ENSMUSP00000039600","abundance":1.75,"rank":8913,"name":"Ccl5","annotation":"C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family."},{"id":"ENSMUSP00000129420","abundance":1.75,"rank":8914,"name":"Diaph3","annotation":"Protein diaphanous homolog 3; Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nuc [...] "},{"id":"ENSMUSP00000099559","abundance":1.74,"rank":8915,"name":"Vps39","annotation":"Vam6/Vps39-like protein; May play a role in clustering and fusion of late endosomes and lysosomes (By similarity). Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2- dependent transcription (By similarity). Belongs to the VAM6/VPS39 family."},{"id":"ENSMUSP00000033161","abundance":1.74,"rank":8916,"name":"Scnn1b","annotation":"Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception."},{"id":"ENSMUSP00000102782","abundance":1.74,"rank":8917,"name":"Cd300lg","annotation":"CMRF35-like molecule 9; Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte. Belongs to the CD300 family."},{"id":"ENSMUSP00000030662","abundance":1.74,"rank":8918,"name":"Gpatch3","annotation":"G patch domain-containing protein 3; Involved in transcriptional regulation. It is able to activate transcription from CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6."},{"id":"ENSMUSP00000023813","abundance":1.74,"rank":8919,"name":"Tarbp2","annotation":"RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] "},{"id":"ENSMUSP00000112703","abundance":1.74,"rank":8920,"name":"Dnajb3","annotation":"DnaJ homolog subfamily B member 3; May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins."},{"id":"ENSMUSP00000140761","abundance":1.74,"rank":8921,"name":"Thap4","annotation":"THAP domain-containing protein 4."},{"id":"ENSMUSP00000034443","abundance":1.74,"rank":8922,"name":"Cdh15","annotation":"Cadherin-15; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation."},{"id":"ENSMUSP00000096057","abundance":1.74,"rank":8923,"name":"Il20rb","annotation":"Interleukin 20 receptor beta."},{"id":"ENSMUSP00000141646","abundance":1.74,"rank":8924,"name":"Pigc","annotation":"Phosphatidylinositol N-acetylglucosaminyltransferase subunit C; Involved in GPI anchor biosynthesis. Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N- acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis."},{"id":"ENSMUSP00000028243","abundance":1.74,"rank":8925,"name":"4930568D16Rik","annotation":"N-acetyllactosaminide alpha-1,3-galactosyltransferase-like 1; Synthesizes the galactose-alpha(1,3)-galactose group by catalyzing the transfer of a galactose residue, with an alpha-1,3 linkage, on terminal lactosaminide (Gal-beta-1,4-GlcNAc-R) disaccharide borne by a glycoprotein or a glycolipid."},{"id":"ENSMUSP00000034570","abundance":1.74,"rank":8926,"name":"Pts","annotation":"6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin."},{"id":"ENSMUSP00000094882","abundance":1.74,"rank":8927,"name":"Heatr5b","annotation":"HEAT repeat-containing protein 5B."},{"id":"ENSMUSP00000131373","abundance":1.74,"rank":8928,"name":"Rnf19b","annotation":"E3 ubiquitin-protein ligase RNF19B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells. Protects against staurosporin-induced cell death (By similarity)."},{"id":"ENSMUSP00000040360","abundance":1.74,"rank":8929,"name":"Zcchc14","annotation":"Zinc finger CCHC domain-containing protein 14."},{"id":"ENSMUSP00000061906","abundance":1.74,"rank":8930,"name":"Lrrc24","annotation":"Leucine-rich repeat-containing protein 24."},{"id":"ENSMUSP00000043730","abundance":1.73,"rank":8931,"name":"Dph5","annotation":"Diphthine methyl ester synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis."},{"id":"ENSMUSP00000047042","abundance":1.73,"rank":8932,"name":"Ankrd54","annotation":"Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation."},{"id":"ENSMUSP00000030531","abundance":1.73,"rank":8933,"name":"Pla2g2e","annotation":"Group IIE secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides."},{"id":"ENSMUSP00000128634","abundance":1.73,"rank":8934,"name":"Nabp2","annotation":"SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] "},{"id":"ENSMUSP00000149492","abundance":1.73,"rank":8935,"name":"Olfr510","annotation":"Olfactory receptor 510; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000048636","abundance":1.73,"rank":8936,"name":"Mettl18","annotation":"Histidine protein methyltransferase 1 homolog; Probable histidine methyltransferase; Belongs to the methyltransferase superfamily. METTL18 family."},{"id":"ENSMUSP00000015622","abundance":1.73,"rank":8937,"name":"Rnf5","annotation":"E3 ubiquitin-protein ligase RNF5; Has E2-dependent E3 ubiquitin-protein ligase activity. May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4. Mediates ubiquitination of PXN/paxillin. May be involved in regulation of cell motility and localization of PXN/paxillin. Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N. Mediates the 'Lys-48'- linked polyubiquitination [...] "},{"id":"ENSMUSP00000028336","abundance":1.73,"rank":8938,"name":"Arl6ip6","annotation":"ADP-ribosylation factor-like protein 6-interacting protein 6."},{"id":"ENSMUSP00000045911","abundance":1.73,"rank":8939,"name":"Gpsm3","annotation":"G-protein-signaling modulator 3; Interacts with subunit of G(i) alpha proteins and regulates the activation of G(i) alpha proteins."},{"id":"ENSMUSP00000047735","abundance":1.73,"rank":8940,"name":"Rab42","annotation":"Ras-related protein Rab-42."},{"id":"ENSMUSP00000110914","abundance":1.73,"rank":8941,"name":"Tmem60","annotation":"Transmembrane protein 60."},{"id":"ENSMUSP00000029568","abundance":1.73,"rank":8942,"name":"Tmem144","annotation":"Transmembrane protein 144."},{"id":"ENSMUSP00000139389","abundance":1.73,"rank":8943,"name":"Htr1b","annotation":"5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] "},{"id":"ENSMUSP00000027856","abundance":1.73,"rank":8944,"name":"Dcaf6","annotation":"DDB1- and CUL4-associated factor 6; Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity)."},{"id":"ENSMUSP00000030872","abundance":1.73,"rank":8945,"name":"Orc5","annotation":"Origin recognition complex subunit 5; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication; Belongs to the ORC5 family."},{"id":"ENSMUSP00000041907","abundance":1.73,"rank":8946,"name":"F11r","annotation":"Junctional adhesion molecule A; Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (By similarity). Involved in platelet activation (By similarity); Belongs to the immunoglobulin superfamily."},{"id":"ENSMUSP00000030181","abundance":1.73,"rank":8947,"name":"Ccdc107","annotation":"Coiled-coil domain-containing protein 107."},{"id":"ENSMUSP00000094083","abundance":1.73,"rank":8948,"name":"Csf2rb2","annotation":"Interleukin-3 receptor class 2 subunit beta; In mouse, there are two classes of high-affinity IL3 receptors. One contains this IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors."},{"id":"ENSMUSP00000093968","abundance":1.73,"rank":8949,"name":"Ints5","annotation":"Integrator complex subunit 5; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex."},{"id":"ENSMUSP00000055823","abundance":1.73,"rank":8950,"name":"Pstpip1","annotation":"Proline-serine-threonine phosphatase-interacting protein 1; Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T- cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates  [...] "},{"id":"ENSMUSP00000102563","abundance":1.73,"rank":8951,"name":"Xndc1","annotation":"Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough."},{"id":"ENSMUSP00000034537","abundance":1.73,"rank":8952,"name":"St3gal4","annotation":"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4- GlcNAc-, and NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids."},{"id":"ENSMUSP00000151211","abundance":1.72,"rank":8953,"name":"Olfr988","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000125797","abundance":1.72,"rank":8954,"name":"Mocs2","annotation":"Molybdopterin synthase catalytic subunit; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group."},{"id":"ENSMUSP00000137525","abundance":1.72,"rank":8955,"name":"5730507C01Rik","annotation":"RIKEN cDNA 5730507C01 gene."},{"id":"ENSMUSP00000033383","abundance":1.72,"rank":8956,"name":"Usp11","annotation":"Ubiquitin carboxyl-terminal hydrolase 11; Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys- 63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys- 33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA brea [...] "},{"id":"ENSMUSP00000120534","abundance":1.72,"rank":8957,"name":"Gm12830","annotation":"Predicted gene 12830."},{"id":"ENSMUSP00000031549","abundance":1.72,"rank":8958,"name":"Gm4951","annotation":"Interferon-gamma-inducible GTPase Ifgga2 protein."},{"id":"ENSMUSP00000105181","abundance":1.72,"rank":8959,"name":"Zc3h7b","annotation":"Zinc finger CCCH type-containing 7B."},{"id":"ENSMUSP00000026154","abundance":1.72,"rank":8960,"name":"Zdhhc16","annotation":"Palmitoyltransferase ZDHHC16; Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6. Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization. Also required for eye development. Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response. May be involved in apoptosis regulation. Involved in the proliferation of neural stem cells by re [...] "},{"id":"ENSMUSP00000061337","abundance":1.72,"rank":8961,"name":"Lca5l","annotation":"Lebercilin-like protein."},{"id":"ENSMUSP00000127619","abundance":1.72,"rank":8962,"name":"Serpinb6c","annotation":"Serine (or cysteine) peptidase inhibitor, clade B, member 6c; Belongs to the serpin family."},{"id":"ENSMUSP00000080650","abundance":1.72,"rank":8963,"name":"Rnf217","annotation":"Probable E3 ubiquitin-protein ligase RNF217; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates."},{"id":"ENSMUSP00000020399","abundance":1.72,"rank":8964,"name":"Cpm","annotation":"Carboxypeptidase M; Specifically removes C-terminal basic residues (Arg or Lys) from peptides and proteins. It is believed to play important roles in the control of peptide hormone and growth factor activity at the cell surface, and in the membrane-localized degradation of extracellular proteins (By similarity)."},{"id":"ENSMUSP00000042317","abundance":1.72,"rank":8965,"name":"Nfkbid","annotation":"NF-kappa-B inhibitor delta; Regulates the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR). According to it may also regulate TCR-induced negative selection of thymocytes."},{"id":"ENSMUSP00000102801","abundance":1.72,"rank":8966,"name":"Anxa9","annotation":"Annexin A9; May act as a low affinity receptor for acetylcholine. Belongs to the annexin family."},{"id":"ENSMUSP00000092006","abundance":1.72,"rank":8967,"name":"Hes3","annotation":"Transcription factor HES-3; Transcriptional repressor of genes that require a bHLH protein for their transcription."},{"id":"ENSMUSP00000155083","abundance":1.72,"rank":8968,"name":"Bik","annotation":"Bcl-2-interacting killer; Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity."},{"id":"ENSMUSP00000075226","abundance":1.72,"rank":8969,"name":"Mrpl42","annotation":"39S ribosomal protein L42, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mL42 family."},{"id":"ENSMUSP00000017839","abundance":1.72,"rank":8970,"name":"Rnf135","annotation":"E3 ubiquitin-protein ligase RNF135; E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIG-I/DDX58 filaments forming on longer viral RNAs, further activates th [...] "},{"id":"ENSMUSP00000081319","abundance":1.72,"rank":8971,"name":"Cdca8","annotation":"Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment (By similarity); Belongs to the borealin family."},{"id":"ENSMUSP00000133459","abundance":1.72,"rank":8972,"name":"Moap1","annotation":"Modulator of apoptosis 1; Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation (By similarity)."},{"id":"ENSMUSP00000002080","abundance":1.72,"rank":8973,"name":"Pdzd4","annotation":"PDZ domain-containing protein 4."},{"id":"ENSMUSP00000035434","abundance":1.71,"rank":8974,"name":"Tmem127","annotation":"Transmembrane protein 127; Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor; Belongs to the TMEM127 family."},{"id":"ENSMUSP00000139040","abundance":1.71,"rank":8975,"name":"Ssxb8","annotation":"Synovial sarcoma, X member B8."},{"id":"ENSMUSP00000039750","abundance":1.71,"rank":8976,"name":"Cylc2","annotation":"Cylicin, basic protein of sperm head cytoskeleton 2."},{"id":"ENSMUSP00000039301","abundance":1.71,"rank":8977,"name":"Mios","annotation":"GATOR complex protein MIOS; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1."},{"id":"ENSMUSP00000005952","abundance":1.71,"rank":8978,"name":"Slc30a4","annotation":"Zinc transporter 4; Probably involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment."},{"id":"ENSMUSP00000057623","abundance":1.71,"rank":8979,"name":"Lix1l","annotation":"LIX1-like protein; Belongs to the LIX1 family."},{"id":"ENSMUSP00000151545","abundance":1.71,"rank":8980,"name":"Ppfia2","annotation":"Liprin-alpha-2; Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines; Belongs to the liprin family. Liprin-alpha subfamily."},{"id":"ENSMUSP00000031280","abundance":1.71,"rank":8981,"name":"Fgf5","annotation":"Fibroblast growth factor 5; Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity)."},{"id":"ENSMUSP00000149081","abundance":1.71,"rank":8982,"name":"Olfr747","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000049851","abundance":1.71,"rank":8983,"name":"Ino80e","annotation":"INO80 complex subunit E."},{"id":"ENSMUSP00000109599","abundance":1.71,"rank":8984,"name":"Il1rapl1","annotation":"Interleukin-1 receptor accessory protein-like 1; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK (By similarity). Plays a role in neurite outgrowth (By similarity). During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD. ECO:0000250|UniProtKB:Q9NZN1."},{"id":"ENSMUSP00000152852","abundance":1.71,"rank":8985,"name":"Snapc1l","annotation":"Small nuclear RNA-activating complex, polypeptide 1-like."},{"id":"ENSMUSP00000008297","abundance":1.71,"rank":8986,"name":"Clstn3","annotation":"Calsyntenin-3; May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation."},{"id":"ENSMUSP00000113799","abundance":1.71,"rank":8987,"name":"Gm49340","annotation":"Predicted gene, 49340."},{"id":"ENSMUSP00000039641","abundance":1.71,"rank":8988,"name":"Il25","annotation":"Interleukin 25."},{"id":"ENSMUSP00000031651","abundance":1.71,"rank":8989,"name":"Pan3","annotation":"PAN2-PAN3 deadenylation complex subunit Pan3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] "},{"id":"ENSMUSP00000002412","abundance":1.71,"rank":8990,"name":"Ncan","annotation":"Neurocan core protein; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N- CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid."},{"id":"ENSMUSP00000042551","abundance":1.71,"rank":8991,"name":"Kif16b","annotation":"Kinesin-like protein KIF16B; Plus end-directed microtubule-dependent motor protein involved in endosome transport and receptor recycling and degradation. Regulates the plus end motility of early endosomes and the balance between recycling and degradation of receptors such as EGF receptor (EGFR) and FGF receptor (FGFR). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development."},{"id":"ENSMUSP00000041774","abundance":1.71,"rank":8992,"name":"Gata6","annotation":"Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection (By similarity). Involved in gene regulation specifically in the gastric epithelium (By similarity). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions."},{"id":"ENSMUSP00000038801","abundance":1.71,"rank":8993,"name":"Mcoln3","annotation":"Mucolipin-3; Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)- permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during [...] "},{"id":"ENSMUSP00000020439","abundance":1.71,"rank":8994,"name":"Wif1","annotation":"Wnt inhibitory factor 1; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation."},{"id":"ENSMUSP00000063016","abundance":1.71,"rank":8995,"name":"AI467606","annotation":"Transmembrane protein C16orf54 homolog."},{"id":"ENSMUSP00000023884","abundance":1.71,"rank":8996,"name":"Ldc1","annotation":"Leucine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family."},{"id":"ENSMUSP00000020821","abundance":1.71,"rank":8997,"name":"Tubd1","annotation":"Tubulin delta chain; Acts as a positive regulator of hedgehog signaling and regulates ciliary function. Belongs to the tubulin family."},{"id":"ENSMUSP00000091053","abundance":1.71,"rank":8998,"name":"Urgcp","annotation":"Up-regulator of cell proliferation; May be involved in cell cycle progression through the regulation of cyclin D1 expression."},{"id":"ENSMUSP00000056529","abundance":1.71,"rank":8999,"name":"Btbd8","annotation":"BTB/POZ domain-containing protein 8."},{"id":"ENSMUSP00000056752","abundance":1.71,"rank":9000,"name":"Fgf4","annotation":"Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis; Belongs to the heparin-binding growth factors family."},{"id":"ENSMUSP00000061345","abundance":1.7,"rank":9001,"name":"Brox","annotation":"BRO1 domain-containing protein BROX."},{"id":"ENSMUSP00000122623","abundance":1.7,"rank":9002,"name":"Mri1","annotation":"Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily."},{"id":"ENSMUSP00000150627","abundance":1.7,"rank":9003,"name":"Olfr749","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000078337","abundance":1.7,"rank":9004,"name":"Apc","annotation":"Adenomatous polyposis coli protein; Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)- induced cell migration (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane a [...] "},{"id":"ENSMUSP00000067580","abundance":1.7,"rank":9005,"name":"A330070K13Rik","annotation":"RIKEN cDNA A330070K13 gene."},{"id":"ENSMUSP00000111062","abundance":1.7,"rank":9006,"name":"Slco5a1","annotation":"Solute carrier organic anion transporter family member."},{"id":"ENSMUSP00000067964","abundance":1.7,"rank":9007,"name":"Gpsm1","annotation":"G-protein-signaling modulator 1; Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein- coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. Belongs to the GPSM family."},{"id":"ENSMUSP00000029188","abundance":1.7,"rank":9008,"name":"Ccn5","annotation":"CCN family member 5; May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production (By similarity); Belongs to the CCN family."},{"id":"ENSMUSP00000025711","abundance":1.7,"rank":9009,"name":"Vps51","annotation":"Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome- derived carriers to the TGN. Acts as component of the EARP complex [...] "},{"id":"ENSMUSP00000034597","abundance":1.7,"rank":9010,"name":"Tmprss13","annotation":"Transmembrane protease serine 13."},{"id":"ENSMUSP00000046856","abundance":1.7,"rank":9011,"name":"Lss","annotation":"Lanosterol synthase; Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency."},{"id":"ENSMUSP00000023562","abundance":1.7,"rank":9012,"name":"Tmem41a","annotation":"Transmembrane protein 41A; Belongs to the TMEM41 family."},{"id":"ENSMUSP00000106801","abundance":1.7,"rank":9013,"name":"Pom121","annotation":"Nuclear envelope pore membrane protein POM 121; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) (By similarity). Belongs to the POM121 family."},{"id":"ENSMUSP00000022119","abundance":1.7,"rank":9014,"name":"Atg10","annotation":"Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Plays a role in adenovirus-mediated cell lysis."},{"id":"ENSMUSP00000149840","abundance":1.7,"rank":9015,"name":"Olfr49","annotation":"Olfactory receptor 49; Odorant receptor. Activated by (-)-citronellal and to a lesser extent by (+)-citronellal. Not activated by carvone or limonene. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000052306","abundance":1.7,"rank":9016,"name":"Plppr4","annotation":"Phospholipid phosphatase-related protein type 4; Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid- induced axon collapse in neurons and facilitates outgrowth in the hippocampus (By similarity)."},{"id":"ENSMUSP00000005504","abundance":1.7,"rank":9017,"name":"Fbxo11","annotation":"F-box only protein 11; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cel [...] "},{"id":"ENSMUSP00000113231","abundance":1.7,"rank":9018,"name":"Mmp27","annotation":"Matrix metallopeptidase 27."},{"id":"ENSMUSP00000020500","abundance":1.7,"rank":9019,"name":"Appl2","annotation":"DCC-interacting protein 13-beta; Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interactio [...] "},{"id":"ENSMUSP00000032094","abundance":1.7,"rank":9020,"name":"Fbxl14","annotation":"F-box/LRR-repeat protein 14; Substrate-recognition component of some (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1 (By similarity)."},{"id":"ENSMUSP00000054428","abundance":1.7,"rank":9021,"name":"Mib1","annotation":"E3 ubiquitin-protein ligase MIB1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation (By similarity). Probably mediates  [...] "},{"id":"ENSMUSP00000019290","abundance":1.7,"rank":9022,"name":"Cacng2","annotation":"Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity)."},{"id":"ENSMUSP00000140347","abundance":1.7,"rank":9023,"name":"1700088E04Rik","annotation":"UPF0193 protein EVG1 homolog; Belongs to the UPF0193 (EVG1) family."},{"id":"ENSMUSP00000006854","abundance":1.7,"rank":9024,"name":"Usp19","annotation":"Ubiquitin carboxyl-terminal hydrolase 19; Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin-dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic-reticulum-associated degradation (ERAD) substrates (By similarity). Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preve [...] "},{"id":"ENSMUSP00000041247","abundance":1.7,"rank":9025,"name":"Ubr7","annotation":"Putative E3 ubiquitin-protein ligase UBR7; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation."},{"id":"ENSMUSP00000050745","abundance":1.7,"rank":9026,"name":"Apol7c","annotation":"Apolipoprotein L 7c."},{"id":"ENSMUSP00000069077","abundance":1.7,"rank":9027,"name":"Klhl26","annotation":"Kelch-like protein 26."},{"id":"ENSMUSP00000101708","abundance":1.7,"rank":9028,"name":"Zmym1","annotation":"Zinc finger, MYM domain-containing 1."},{"id":"ENSMUSP00000121862","abundance":1.7,"rank":9029,"name":"Tmem141","annotation":"Transmembrane protein 141."},{"id":"ENSMUSP00000146705","abundance":1.7,"rank":9030,"name":"Gm9999","annotation":"Predicted gene 9999."},{"id":"ENSMUSP00000099983","abundance":1.7,"rank":9031,"name":"Abca2","annotation":"ATP-binding cassette sub-family A member 2; Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development; Belongs to the ABC transporter superfamily. ABCA family."},{"id":"ENSMUSP00000092198","abundance":1.7,"rank":9032,"name":"Albfm1","annotation":"Albumin superfamily member 1."},{"id":"ENSMUSP00000054748","abundance":1.7,"rank":9033,"name":"Amer3","annotation":"APC membrane recruitment protein 3; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane (By similarity). Belongs to the Amer family."},{"id":"ENSMUSP00000085260","abundance":1.69,"rank":9034,"name":"Med12","annotation":"Mediator of RNA polymerase II transcription subunit 12; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifi [...] "},{"id":"ENSMUSP00000091375","abundance":1.69,"rank":9035,"name":"Nxpe4","annotation":"NXPE family member 4; Belongs to the NXPE family."},{"id":"ENSMUSP00000055689","abundance":1.69,"rank":9036,"name":"Pdss1","annotation":"Decaprenyl-diphosphate synthase subunit 1; Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. Belongs to the FPP/GGPP synthase family."},{"id":"ENSMUSP00000088453","abundance":1.69,"rank":9037,"name":"Acvr1","annotation":"Activin receptor type-1; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily."},{"id":"ENSMUSP00000048204","abundance":1.69,"rank":9038,"name":"Utp15","annotation":"U3 small nucleolar RNA-associated protein 15 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I."},{"id":"ENSMUSP00000032272","abundance":1.69,"rank":9039,"name":"Adipor2","annotation":"Adiponectin receptor protein 2; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels."},{"id":"ENSMUSP00000075283","abundance":1.69,"rank":9040,"name":"Zic2","annotation":"Zinc finger protein ZIC 2; Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye- specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5' [...] "},{"id":"ENSMUSP00000049834","abundance":1.69,"rank":9041,"name":"Cir1","annotation":"Corepressor interacting with RBPJ 1; Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). May modulate splice site selection during alternative splicing of pre- mRNAs."},{"id":"ENSMUSP00000042825","abundance":1.69,"rank":9042,"name":"Tmem98","annotation":"Transmembrane protein 98; Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1)."},{"id":"ENSMUSP00000100944","abundance":1.69,"rank":9043,"name":"Btbd11","annotation":"Ankyrin repeat and BTB/POZ domain-containing protein BTBD11."},{"id":"ENSMUSP00000099407","abundance":1.69,"rank":9044,"name":"Kat2a","annotation":"Histone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context. Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinyl [...] "},{"id":"ENSMUSP00000055035","abundance":1.69,"rank":9045,"name":"Krtap31-2","annotation":"Keratin-associated protein 31-2."},{"id":"ENSMUSP00000091467","abundance":1.69,"rank":9046,"name":"Krtap31-1","annotation":"Keratin-associated protein 31-1."},{"id":"ENSMUSP00000149542","abundance":1.69,"rank":9047,"name":"Olfr401","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000081872","abundance":1.69,"rank":9048,"name":"Olfr586","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000043222","abundance":1.69,"rank":9049,"name":"Chst7","annotation":"Carbohydrate sulfotransferase 7; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4 [...] "},{"id":"ENSMUSP00000023806","abundance":1.69,"rank":9050,"name":"Soat2","annotation":"Sterol O-acyltransferase 2; Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa; Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily."},{"id":"ENSMUSP00000030372","abundance":1.69,"rank":9051,"name":"Col9a2","annotation":"Collagen alpha-2(IX) chain; Structural component of hyaline cartilage and vitreous of the eye."},{"id":"ENSMUSP00000098106","abundance":1.69,"rank":9052,"name":"Zc3h3","annotation":"Zinc finger CCCH domain-containing protein 3; Required for the export of polyadenylated mRNAs from the nucleus (By similarity). Enhances ACVR1B-induced SMAD-dependent transcription. Binds to single-stranded DNA but not to double-stranded DNA in vitro. Involved in RNA cleavage."},{"id":"ENSMUSP00000107546","abundance":1.69,"rank":9053,"name":"Fam234b","annotation":"Protein FAM234B; Belongs to the FAM234 family."},{"id":"ENSMUSP00000022881","abundance":1.69,"rank":9054,"name":"Retreg1","annotation":"Reticulophagy regulator 1; Endoplasmic reticulum-anchored autophagy receptor that mediates ER delivery into lysosomes through sequestration into autophagosomes. Promotes membrane remodeling and ER scission via its membrane bending capacity and targets the fragments into autophagosomes via interaction with ATG8 family proteins. Required for long-term survival of nociceptive and autonomic ganglion neurons."},{"id":"ENSMUSP00000151576","abundance":1.69,"rank":9055,"name":"Zfp781","annotation":"Zinc finger protein 781."},{"id":"ENSMUSP00000151912","abundance":1.69,"rank":9056,"name":"Gm3055","annotation":"Predicted gene 3055."},{"id":"ENSMUSP00000072961","abundance":1.68,"rank":9057,"name":"Slc52a3","annotation":"Solute carrier family 52, riboflavin transporter, member 3; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism."},{"id":"ENSMUSP00000095030","abundance":1.68,"rank":9058,"name":"Fgfr1op","annotation":"FGFR1 oncogene partner; Required for anchoring microtubules to the centrosomes. Required for ciliation; Belongs to the FGFR1OP family."},{"id":"ENSMUSP00000098680","abundance":1.68,"rank":9059,"name":"Gpr27","annotation":"Probable G-protein coupled receptor 27; Orphan receptor. Possible candidate for amine-like G-protein coupled receptor (By similarity)."},{"id":"ENSMUSP00000026547","abundance":1.68,"rank":9060,"name":"Tubgcp2","annotation":"Gamma-tubulin complex component 2; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome."},{"id":"ENSMUSP00000136476","abundance":1.68,"rank":9061,"name":"ENSMUSP00000136476","annotation":"annotation not available"},{"id":"ENSMUSP00000111591","abundance":1.68,"rank":9062,"name":"ENSMUSP00000111591","annotation":"annotation not available"},{"id":"ENSMUSP00000027380","abundance":1.68,"rank":9063,"name":"Tmem169","annotation":"Transmembrane protein 169."},{"id":"ENSMUSP00000129728","abundance":1.68,"rank":9064,"name":"Nup37","annotation":"Nucleoporin Nup37; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation (By similarity)."},{"id":"ENSMUSP00000127413","abundance":1.68,"rank":9065,"name":"Borcs5","annotation":"BLOC-1-related complex subunit 5; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. Thereby, it may indirectly play a role in cell spreading and motility. Belongs to the BORCS5 family."},{"id":"ENSMUSP00000031331","abundance":1.68,"rank":9066,"name":"Ccng2","annotation":"Cyclin-G2; May play a role in growth regulation and in negative regulation of cell cycle progression."},{"id":"ENSMUSP00000136372","abundance":1.68,"rank":9067,"name":"Foxg1","annotation":"Forkhead box protein G1; Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon."},{"id":"ENSMUSP00000107062","abundance":1.68,"rank":9068,"name":"Mpzl1","annotation":"Myelin protein zero-like protein 1; Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 2 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2, may be involved in regulation of integrin-mediated cell motility (By similarity); Belongs  [...] "},{"id":"ENSMUSP00000151985","abundance":1.68,"rank":9069,"name":"Apba3","annotation":"Amyloid-beta A4 precursor protein-binding family A member 3; May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN (By similarity)."},{"id":"ENSMUSP00000042572","abundance":1.68,"rank":9070,"name":"Spata20","annotation":"Spermatogenesis-associated protein 20; May play a role in fertility regulation."},{"id":"ENSMUSP00000095597","abundance":1.68,"rank":9071,"name":"Nps","annotation":"Neuropeptide S; May play an important anorexigenic role. Modulates arousal and anxiety as well as increases locomotor activity. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations."},{"id":"ENSMUSP00000080467","abundance":1.67,"rank":9072,"name":"Nfe2l1","annotation":"Endoplasmic reticulum membrane sensor NFE2L1; [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor. Constitutes a precursor of the transcription factor NRF1. Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition. In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF [...] "},{"id":"ENSMUSP00000112790","abundance":1.67,"rank":9073,"name":"Zwilch","annotation":"Protein zwilch homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity)."},{"id":"ENSMUSP00000082489","abundance":1.67,"rank":9074,"name":"Slc17a7","annotation":"Vesicular glutamate transporter 1; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate."},{"id":"ENSMUSP00000148717","abundance":1.67,"rank":9075,"name":"Zfp612","annotation":"Zinc finger protein 612."},{"id":"ENSMUSP00000107198","abundance":1.67,"rank":9076,"name":"Pramel6","annotation":"Preferentially-expressed antigen in melanoma-like 6."},{"id":"ENSMUSP00000025468","abundance":1.67,"rank":9077,"name":"Pde6a","annotation":"Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; This protein participates in processes of transmission and amplification of the visual signal."},{"id":"ENSMUSP00000076188","abundance":1.67,"rank":9078,"name":"Arl16","annotation":"ADP-ribosylation factor-like 16."},{"id":"ENSMUSP00000049161","abundance":1.67,"rank":9079,"name":"Ctf1","annotation":"Cardiotrophin-1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor."},{"id":"ENSMUSP00000021959","abundance":1.67,"rank":9080,"name":"Txndc15","annotation":"Thioredoxin domain-containing protein 15; Acts as a positive regulator of ciliary hedgehog signaling. Required for cilia biogenesis."},{"id":"ENSMUSP00000109606","abundance":1.67,"rank":9081,"name":"Kmt5b","annotation":"Histone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] "},{"id":"ENSMUSP00000108205","abundance":1.67,"rank":9082,"name":"Apobec1","annotation":"C->U-editing enzyme APOBEC-1; Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation; Belongs to the cytidine and deoxycytidylate deaminase family."},{"id":"ENSMUSP00000013693","abundance":1.67,"rank":9083,"name":"Commd8","annotation":"COMM domain-containing protein 8; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B."},{"id":"ENSMUSP00000087102","abundance":1.67,"rank":9084,"name":"Astl","annotation":"Astacin-like metalloendopeptidase; Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding."},{"id":"ENSMUSP00000157447","abundance":1.67,"rank":9085,"name":"Cyp4f17","annotation":"Cytochrome P450, family 4, subfamily f, polypeptide 17; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000115750","abundance":1.67,"rank":9086,"name":"Dna2","annotation":"DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavag [...] "},{"id":"ENSMUSP00000051800","abundance":1.67,"rank":9087,"name":"Ggnbp1","annotation":"Gametogenetin-binding protein 1; Induces mitochondrial fragmentation, possibly by promoting DNM1L-dependent fission and may play a role in mitochondrial morphogenesis during spermatogenesis."},{"id":"ENSMUSP00000094886","abundance":1.67,"rank":9088,"name":"Togaram2","annotation":"TOG array regulator of axonemal microtubules protein 2."},{"id":"ENSMUSP00000022609","abundance":1.67,"rank":9089,"name":"Elp3","annotation":"Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at pos [...] "},{"id":"ENSMUSP00000035879","abundance":1.67,"rank":9090,"name":"Alg5","annotation":"Dolichyl-phosphate beta-glucosyltransferase."},{"id":"ENSMUSP00000032427","abundance":1.67,"rank":9091,"name":"Ints13","annotation":"Integrator complex subunit 13; Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing."},{"id":"ENSMUSP00000088217","abundance":1.67,"rank":9092,"name":"Ampd1","annotation":"AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism."},{"id":"ENSMUSP00000141769","abundance":1.66,"rank":9093,"name":"Cep170","annotation":"Centrosomal protein of 170 kDa; Plays a role in microtubule organization. Required for centriole subdistal appendage assembly."},{"id":"ENSMUSP00000025271","abundance":1.66,"rank":9094,"name":"Pou5f1","annotation":"POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily."},{"id":"ENSMUSP00000042828","abundance":1.66,"rank":9095,"name":"1700017N19Rik","annotation":"RIKEN cDNA 1700017N19 gene."},{"id":"ENSMUSP00000065308","abundance":1.66,"rank":9096,"name":"Klk13","annotation":"Kallikrein-related-peptidase 13; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000112871","abundance":1.66,"rank":9097,"name":"Ncapg","annotation":"Non-SMC condensin I complex, subunit G."},{"id":"ENSMUSP00000159188","abundance":1.66,"rank":9098,"name":"Amer2","annotation":"APC membrane recruitment protein 2; Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity); Belongs to the Amer family."},{"id":"ENSMUSP00000031446","abundance":1.66,"rank":9099,"name":"Tmem132b","annotation":"Transmembrane protein 132B."},{"id":"ENSMUSP00000061578","abundance":1.66,"rank":9100,"name":"Lypd6","annotation":"Ly6/PLAUR domain-containing protein 6; Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Enhances nicotine-induced Ca(2+) influx through nAChRs. Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity)."},{"id":"ENSMUSP00000020681","abundance":1.66,"rank":9101,"name":"Slu7","annotation":"Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. Belongs to the SLU7 family."},{"id":"ENSMUSP00000076071","abundance":1.66,"rank":9102,"name":"4632433K11Rik","annotation":"RIKEN cDNA 4632433K11 gene."},{"id":"ENSMUSP00000054883","abundance":1.66,"rank":9103,"name":"Cd300e","annotation":"CMRF35-like molecule 2; Probably acts as an activating receptor."},{"id":"ENSMUSP00000047881","abundance":1.66,"rank":9104,"name":"Dock9","annotation":"Dedicator of cytokinesis protein 9; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP. Overexpression induces filopodia formation (By similarity)."},{"id":"ENSMUSP00000158647","abundance":1.66,"rank":9105,"name":"Lsmem2","annotation":"Leucine-rich single-pass membrane protein 2."},{"id":"ENSMUSP00000046766","abundance":1.66,"rank":9106,"name":"Hectd1","annotation":"E3 ubiquitin-protein ligase HECTD1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates 'Lys-63'-linked polyubiquitination of HSP90AA1 which leads to its intracellular localization and reduced secretion. Negatively regulating HSP90AA1 secretion in cranial mesenchyme cells impairs their emigration and is consequently essential for the correct development of the cranial neural folds and neural tube closure ; Belongs to the UPL family. K-HECT subfamily."},{"id":"ENSMUSP00000025704","abundance":1.66,"rank":9107,"name":"Cdca5","annotation":"Sororin; Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair."},{"id":"ENSMUSP00000108985","abundance":1.66,"rank":9108,"name":"Pcdh11x","annotation":"Protocadherin 11 X-linked."},{"id":"ENSMUSP00000004657","abundance":1.66,"rank":9109,"name":"Psg19","annotation":"Pregnancy-specific glycoprotein 19."},{"id":"ENSMUSP00000000641","abundance":1.66,"rank":9110,"name":"Sema4f","annotation":"Semaphorin-4F; Probable cell surface receptor that regulates oligodendroglial precursor cell migration. Might also regulate differentiation of oligodendroglial precursor cells (By similarity). Has growth cone collapse activity against retinal ganglion-cell axons (By similarity)."},{"id":"ENSMUSP00000091647","abundance":1.65,"rank":9111,"name":"Hs3st3b1","annotation":"Heparan sulfate glucosamine 3-O-sulfotransferase 3B1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. Unlike 3-OST-1, does not convert non- anticoagulant heparan sulfate to anticoagulant heparan sulfate (By similarity)."},{"id":"ENSMUSP00000053389","abundance":1.65,"rank":9112,"name":"Rasl11b","annotation":"Ras-like protein family member 11B."},{"id":"ENSMUSP00000038924","abundance":1.65,"rank":9113,"name":"Foxred1","annotation":"FAD-dependent oxidoreductase domain-containing protein 1; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly."},{"id":"ENSMUSP00000074872","abundance":1.65,"rank":9114,"name":"Stard5","annotation":"StAR-related lipid transfer protein 5; May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols."},{"id":"ENSMUSP00000028866","abundance":1.65,"rank":9115,"name":"Zc3h8","annotation":"Zinc finger CCCH domain-containing protein 8; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Acts as a transcriptional repressor of the GATA3 promoter. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis (By similarity). Sequence-specific DNA-binding factor that binds to the 5'- AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene."},{"id":"ENSMUSP00000018623","abundance":1.65,"rank":9116,"name":"1700125H20Rik","annotation":"Uncharacterized protein C17orf64 homolog."},{"id":"ENSMUSP00000037978","abundance":1.65,"rank":9117,"name":"Trim36","annotation":"E3 ubiquitin-protein ligase Trim36; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization ; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000082501","abundance":1.65,"rank":9118,"name":"Scaf1","annotation":"Splicing factor, arginine/serine-rich 19; May function in pre-mRNA splicing; Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000098429","abundance":1.65,"rank":9119,"name":"Ccdc92b","annotation":"Coiled-coil domain-containing 92B."},{"id":"ENSMUSP00000019068","abundance":1.65,"rank":9120,"name":"Alox15","annotation":"Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] "},{"id":"ENSMUSP00000114053","abundance":1.65,"rank":9121,"name":"Cep164","annotation":"Centrosomal protein of 164 kDa; Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1  [...] "},{"id":"ENSMUSP00000092186","abundance":1.65,"rank":9122,"name":"Galk2","annotation":"N-acetylgalactosamine kinase; Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations (By similarity)."},{"id":"ENSMUSP00000149420","abundance":1.65,"rank":9123,"name":"Scn11a","annotation":"Sodium channel protein type 11 subunit alpha; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization (By similarity); Belongs to the sodium channel ( [...] "},{"id":"ENSMUSP00000079548","abundance":1.65,"rank":9124,"name":"Tax1bp1","annotation":"Tax1-binding protein 1 homolog; Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti- apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade (By similarity)."},{"id":"ENSMUSP00000045344","abundance":1.65,"rank":9125,"name":"Clspn","annotation":"Claspin; Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks (By similarity); Belongs [...] "},{"id":"ENSMUSP00000064195","abundance":1.65,"rank":9126,"name":"Rbm12b1","annotation":"RNA-binding protein 12B-A."},{"id":"ENSMUSP00000039065","abundance":1.65,"rank":9127,"name":"Ramac","annotation":"RNA guanine-N7 methyltransferase activating subunit; Regulatory subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Promotes the recruitment of the methyl donor, S-adenosyl-L-methionine, to RNMT. Regulates RNMT expression by a post-transcriptional stabilizing mechanism. Binds RNA."},{"id":"ENSMUSP00000096884","abundance":1.64,"rank":9128,"name":"Kiz","annotation":"Centrosomal protein kizuna; Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. Belongs to the kizuna family."},{"id":"ENSMUSP00000099721","abundance":1.64,"rank":9129,"name":"Sestd1","annotation":"SEC14 domain and spectrin repeat-containing protein 1; May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1 (By similarity); Belongs to the SOLO family."},{"id":"ENSMUSP00000024123","abundance":1.64,"rank":9130,"name":"Agap3","annotation":"Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway."},{"id":"ENSMUSP00000113773","abundance":1.64,"rank":9131,"name":"Nod2","annotation":"Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] "},{"id":"ENSMUSP00000033044","abundance":1.64,"rank":9132,"name":"BC017158","annotation":"RUS1 family protein C16orf58 homolog; Belongs to the RUS1 family."},{"id":"ENSMUSP00000085346","abundance":1.64,"rank":9133,"name":"Nms","annotation":"Neuromedin-S; Implicated in the regulation of circadian rhythms through autocrine and/or paracrine actions; Belongs to the NmU family."},{"id":"ENSMUSP00000108686","abundance":1.64,"rank":9134,"name":"Il1rapl2","annotation":"X-linked interleukin-1 receptor accessory protein-like 2; Belongs to the interleukin-1 receptor family."},{"id":"ENSMUSP00000033737","abundance":1.64,"rank":9135,"name":"Haus7","annotation":"HAUS augmin-like complex subunit 7; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex; Belongs to the HAUS7 family."},{"id":"ENSMUSP00000153090","abundance":1.64,"rank":9136,"name":"Fezf2","annotation":"Fez family zinc finger protein 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation."},{"id":"ENSMUSP00000044265","abundance":1.64,"rank":9137,"name":"0610010F05Rik","annotation":"Uncharacterized protein KIAA1841."},{"id":"ENSMUSP00000129887","abundance":1.64,"rank":9138,"name":"Caps2","annotation":"Calcyphosin-2."},{"id":"ENSMUSP00000034802","abundance":1.64,"rank":9139,"name":"Tent5a","annotation":"Terminal nucleotidyltransferase 5A."},{"id":"ENSMUSP00000144369","abundance":1.64,"rank":9140,"name":"Morc3","annotation":"MORC family CW-type zinc finger protein 3; Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (By similarity). Sumoylated MORC3-NBs can also associate with PML-NBs (By similarity). Recruits TP53 and SP100 to PML- NBs, thus regulating TP53 activity. Binds RNA in vitro (By similarity)."},{"id":"ENSMUSP00000081322","abundance":1.64,"rank":9141,"name":"Akirin2","annotation":"Akirin-2; Forms a complex with YWHAB that acts to repress transcription of DUSP1 (By similarity). Required for embryonic development and the innate immune response. Downstream effector of the Toll-like receptor (TLR), TNF and IL-1 beta signaling pathways leading to the production of IL-6; Belongs to the akirin family."},{"id":"ENSMUSP00000118956","abundance":1.64,"rank":9142,"name":"2700049A03Rik","annotation":"Protein TALPID3; Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (By similarity). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles. Belongs to the TALPID3 family."},{"id":"ENSMUSP00000137143","abundance":1.64,"rank":9143,"name":"Rlbp1","annotation":"Retinaldehyde-binding protein 1; Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11- trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'."},{"id":"ENSMUSP00000132788","abundance":1.64,"rank":9144,"name":"Baalc","annotation":"Brain and acute leukemia cytoplasmic protein; May play a synaptic role at the postsynaptic lipid rafts possibly through interaction with CAMK2A."},{"id":"ENSMUSP00000061234","abundance":1.64,"rank":9145,"name":"Irf2bp1","annotation":"Interferon regulatory factor 2-binding protein 1; Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation."},{"id":"ENSMUSP00000051282","abundance":1.64,"rank":9146,"name":"Pip5kl1","annotation":"Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3."},{"id":"ENSMUSP00000061843","abundance":1.64,"rank":9147,"name":"Ubn1","annotation":"Ubinuclein-1; Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly (By similarity)."},{"id":"ENSMUSP00000068607","abundance":1.64,"rank":9148,"name":"Tmem175","annotation":"Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. Belongs to the TMEM175 family."},{"id":"ENSMUSP00000067581","abundance":1.64,"rank":9149,"name":"Sh3bp4","annotation":"SH3 domain-binding protein 4; May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity)."},{"id":"ENSMUSP00000153359","abundance":1.64,"rank":9150,"name":"Adamts6","annotation":"A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6."},{"id":"ENSMUSP00000018743","abundance":1.64,"rank":9151,"name":"Mief2","annotation":"Mitochondrial dynamics protein MID49; Mitochondrial outer membrane protein which regulates mitochondrial organization. It is required for mitochondrial fission and promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity."},{"id":"ENSMUSP00000046906","abundance":1.63,"rank":9152,"name":"Ppp1r9a","annotation":"Neural tissue-specific F-actin binding protein."},{"id":"ENSMUSP00000135516","abundance":1.63,"rank":9153,"name":"Pbx1","annotation":"Pre-B-cell leukemia transcription factor 1; Plays a role in the cAMP-dependent regulation of CYP17 gene expression via its cAMP-regulatory sequence (CRS1) 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound  [...] "},{"id":"ENSMUSP00000030811","abundance":1.63,"rank":9154,"name":"Errfi1","annotation":"ERBB receptor feedback inhibitor 1; Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus [...] "},{"id":"ENSMUSP00000021900","abundance":1.63,"rank":9155,"name":"Sema4d","annotation":"Semaphorin-4D; Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). Promotes the migration of cerebellar granule cells. Plays a role in the immune system; induces B- cells to aggregate and improves their viability (in vitro) (By si [...] "},{"id":"ENSMUSP00000153904","abundance":1.63,"rank":9156,"name":"Vmn1r208","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000026081","abundance":1.63,"rank":9157,"name":"Pnliprp2","annotation":"Pancreatic lipase-related protein 2; Lipase with broad substrate specificity. Can hydrolyze both phospholipids and galactolipids. Acts preferentially on monoglycerides, phospholipids and galactolipids. Contributes to milk fat hydrolysis (By similarity); Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000043555","abundance":1.63,"rank":9158,"name":"Smg6","annotation":"Telomerase-binding protein EST1A; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER)."},{"id":"ENSMUSP00000071265","abundance":1.63,"rank":9159,"name":"2410002F23Rik","annotation":"RIKEN cDNA 2410002F23 gene."},{"id":"ENSMUSP00000064410","abundance":1.63,"rank":9160,"name":"Kcmf1","annotation":"E3 ubiquitin-protein ligase KCMF1; Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination; Belongs to the KCMF1 family."},{"id":"ENSMUSP00000159083","abundance":1.63,"rank":9161,"name":"Gm11100","annotation":"Predicted gene 11100."},{"id":"ENSMUSP00000104500","abundance":1.63,"rank":9162,"name":"Slc36a1","annotation":"Proton-coupled amino acid transporter 1; Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognizes their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid."},{"id":"ENSMUSP00000027952","abundance":1.63,"rank":9163,"name":"Plxna2","annotation":"Plexin-A2; Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm."},{"id":"ENSMUSP00000046898","abundance":1.63,"rank":9164,"name":"Map11","annotation":"Microtubule-associated protein 11; Microtubule associated protein wich seems to play a role in spindle dynamics and cell division."},{"id":"ENSMUSP00000032130","abundance":1.63,"rank":9165,"name":"Aplf","annotation":"Aprataxin and PNK-like factor; Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. Together with PARP3, promotes the retention of the LIG4-XRCC4 complex on chromatin an [...] "},{"id":"ENSMUSP00000093972","abundance":1.63,"rank":9166,"name":"Uqcc3","annotation":"Ubiquinol-cytochrome-c reductase complex assembly factor 3; Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology; Belongs to the UQCC3 family."},{"id":"ENSMUSP00000049319","abundance":1.63,"rank":9167,"name":"Nubp2","annotation":"Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure ; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily."},{"id":"ENSMUSP00000105716","abundance":1.63,"rank":9168,"name":"Mkks","annotation":"McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis (By similarity). Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. May play a role in protein processing in limb, cardiac and reproductive system development. May play a role in cytokinesis (By similarity)."},{"id":"ENSMUSP00000026411","abundance":1.63,"rank":9169,"name":"Mmp19","annotation":"Matrix metalloproteinase-19; Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis (By similarity). Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin (By similarity)."},{"id":"ENSMUSP00000068380","abundance":1.63,"rank":9170,"name":"Fto","annotation":"Alpha-ketoglutarate-dependent dioxygenase FTO; RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability (By similarity). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (By similarity). Mediates demethylation of N(6),2'- O-dimethyladenosine  [...] "},{"id":"ENSMUSP00000020683","abundance":1.63,"rank":9171,"name":"Hus1","annotation":"Checkpoint protein HUS1; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity  [...] "},{"id":"ENSMUSP00000049967","abundance":1.63,"rank":9172,"name":"Tbc1d8","annotation":"TBC1 domain family member 8; May act as a GTPase-activating protein for Rab family protein(s)."},{"id":"ENSMUSP00000066777","abundance":1.63,"rank":9173,"name":"Lrrc15","annotation":"Leucine-rich repeat-containing protein 15."},{"id":"ENSMUSP00000053434","abundance":1.63,"rank":9174,"name":"Fam186a","annotation":"Protein FAM186A."},{"id":"ENSMUSP00000090820","abundance":1.63,"rank":9175,"name":"Clk4","annotation":"Dual specificity protein kinase CLK4; Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine- rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. La [...] "},{"id":"ENSMUSP00000028955","abundance":1.63,"rank":9176,"name":"Angpt4","annotation":"Angiopoietin-4; Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis."},{"id":"ENSMUSP00000055557","abundance":1.63,"rank":9177,"name":"Gpr61","annotation":"G-protein coupled receptor 61; Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). May be involved in the regulation of food intake and body weight."},{"id":"ENSMUSP00000103250","abundance":1.63,"rank":9178,"name":"Sp2","annotation":"Transcription factor Sp2; Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Belongs to the Sp1 C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000059019","abundance":1.63,"rank":9179,"name":"Itgbl1","annotation":"Integrin beta-like protein 1."},{"id":"ENSMUSP00000151354","abundance":1.63,"rank":9180,"name":"Prf1","annotation":"Perforin-1; Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes."},{"id":"ENSMUSP00000094989","abundance":1.63,"rank":9181,"name":"Tbc1d24","annotation":"TBC1 domain family member 24; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function."},{"id":"ENSMUSP00000053616","abundance":1.63,"rank":9182,"name":"Tk2","annotation":"Thymidine kinase 2, mitochondrial; Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents."},{"id":"ENSMUSP00000092964","abundance":1.63,"rank":9183,"name":"Ccdc110","annotation":"Coiled-coil domain-containing protein 110."},{"id":"ENSMUSP00000058359","abundance":1.62,"rank":9184,"name":"Cts3","annotation":"Cts3 protein; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000104040","abundance":1.62,"rank":9185,"name":"B9d2","annotation":"B9 domain-containing protein 2; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes; Belongs to the B9D family."},{"id":"ENSMUSP00000082758","abundance":1.62,"rank":9186,"name":"Scgb1b27","annotation":"Secretoglobin, family 1B, member 27."},{"id":"ENSMUSP00000080341","abundance":1.62,"rank":9187,"name":"St7","annotation":"Suppressor of tumorigenicity 7 protein; Belongs to the ST7 family."},{"id":"ENSMUSP00000131573","abundance":1.62,"rank":9188,"name":"Herc2","annotation":"E3 ubiquitin-protein ligase HERC2; E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage- induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscil [...] "},{"id":"ENSMUSP00000018805","abundance":1.62,"rank":9189,"name":"Cog1","annotation":"Conserved oligomeric Golgi complex subunit 1; Required for normal Golgi function."},{"id":"ENSMUSP00000027603","abundance":1.62,"rank":9190,"name":"Rgs18","annotation":"Regulator of G-protein signaling 18; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha."},{"id":"ENSMUSP00000125055","abundance":1.62,"rank":9191,"name":"Adck5","annotation":"Uncharacterized aarF domain-containing protein kinase 5; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr)."},{"id":"ENSMUSP00000112404","abundance":1.62,"rank":9192,"name":"Lins1","annotation":"Protein Lines homolog 1."},{"id":"ENSMUSP00000087815","abundance":1.62,"rank":9193,"name":"Rai14","annotation":"Ankycorbin; Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood- testis barrier."},{"id":"ENSMUSP00000110342","abundance":1.62,"rank":9194,"name":"Zbtb20","annotation":"Zinc finger and BTB domain-containing protein 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal."},{"id":"ENSMUSP00000023737","abundance":1.62,"rank":9195,"name":"Dhh","annotation":"Desert hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development."},{"id":"ENSMUSP00000063795","abundance":1.62,"rank":9196,"name":"Irs1","annotation":"Insulin receptor substrate 1; May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity)."},{"id":"ENSMUSP00000106329","abundance":1.62,"rank":9197,"name":"Cdan1","annotation":"Codanin-1; May act as a negative regulator of ASF1 in chromatin assembly."},{"id":"ENSMUSP00000110749","abundance":1.62,"rank":9198,"name":"Oacyl","annotation":"O-acyltransferase like protein; Belongs to the acyltransferase 3 family."},{"id":"ENSMUSP00000061539","abundance":1.62,"rank":9199,"name":"Kdm6a","annotation":"Lysine-specific demethylase 6A; Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity). Plays a demethylase-independent role in chromatin remodeli [...] "},{"id":"ENSMUSP00000094154","abundance":1.62,"rank":9200,"name":"4933412E24Rik","annotation":"Uncharacterized protein CXorf49 homolog."},{"id":"ENSMUSP00000092053","abundance":1.62,"rank":9201,"name":"Rin2","annotation":"Ras and Rab interactor 2; Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP (By similarity); Belongs to the RIN (Ras interaction/interference) family."},{"id":"ENSMUSP00000002809","abundance":1.62,"rank":9202,"name":"Fkbp7","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP7; PPIases accelerate the folding of proteins during protein synthesis."},{"id":"ENSMUSP00000080813","abundance":1.62,"rank":9203,"name":"Trim68","annotation":"E3 ubiquitin-protein ligase TRIM68; Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity."},{"id":"ENSMUSP00000149570","abundance":1.61,"rank":9204,"name":"Olfr427","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000104478","abundance":1.61,"rank":9205,"name":"Fam114a2","annotation":"Protein FAM114A2."},{"id":"ENSMUSP00000003717","abundance":1.61,"rank":9206,"name":"Abcb4","annotation":"Phosphatidylcholine translocator ABCB4; Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi between hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts. Plays a role in the recruitment o [...] "},{"id":"ENSMUSP00000032451","abundance":1.61,"rank":9207,"name":"Slc6a11","annotation":"Sodium- and chloride-dependent GABA transporter 3; Terminates the action of GABA by its high affinity sodium- dependent reuptake into presynaptic terminals. Can also transport beta- alanine and taurine; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A11 subfamily."},{"id":"ENSMUSP00000045828","abundance":1.61,"rank":9208,"name":"Mael","annotation":"Protein maelstrom homolog; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic n [...] "},{"id":"ENSMUSP00000022595","abundance":1.61,"rank":9209,"name":"Rgcc","annotation":"Regulator of cell cycle RGCC; Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation."},{"id":"ENSMUSP00000076682","abundance":1.61,"rank":9210,"name":"Chst15","annotation":"Carbohydrate sulfotransferase 15; Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation t [...] "},{"id":"ENSMUSP00000141620","abundance":1.61,"rank":9211,"name":"Fndc3b","annotation":"Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family."},{"id":"ENSMUSP00000150882","abundance":1.61,"rank":9212,"name":"Olfr239","annotation":"Olfactory receptor 239."},{"id":"ENSMUSP00000150511","abundance":1.61,"rank":9213,"name":"Olfr55","annotation":"Olfactory receptor 55."},{"id":"ENSMUSP00000109608","abundance":1.61,"rank":9214,"name":"Slc5a3","annotation":"Sodium/myo-inositol cotransporter; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function."},{"id":"ENSMUSP00000157661","abundance":1.61,"rank":9215,"name":"Otud6b","annotation":"Deubiquitinase OTUD6B; Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (By similarity). May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (By similarity). May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (By similarity). May also play a role in proteasome assembly and function (By similarity)."},{"id":"ENSMUSP00000126484","abundance":1.61,"rank":9216,"name":"Rnf168","annotation":"E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] "},{"id":"ENSMUSP00000017339","abundance":1.61,"rank":9217,"name":"Zpbp2","annotation":"Zona pellucida-binding protein 2; Is implicated in sperm-oocyte interaction during fertilization."},{"id":"ENSMUSP00000118322","abundance":1.61,"rank":9218,"name":"St18","annotation":"Suppression of tumorigenicity 18 protein; Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5'-AAAGTTT-3' separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity); Belongs to the MYT1 family."},{"id":"ENSMUSP00000128874","abundance":1.61,"rank":9219,"name":"Dlec1","annotation":"Deleted in lung and esophageal cancer protein 1 homolog; May act as a tumor suppressor by inhibiting cell proliferation."},{"id":"ENSMUSP00000041009","abundance":1.61,"rank":9220,"name":"Tesk2","annotation":"Dual specificity testis-specific protein kinase 2; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser- 3'. May play an important role in spermatogenesis (By similarity). Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family."},{"id":"ENSMUSP00000071457","abundance":1.61,"rank":9221,"name":"Ctsj","annotation":"Cathepsin J; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000134057","abundance":1.61,"rank":9222,"name":"Zmym5","annotation":"Zinc finger MYM-type protein 5; Functions as a transcriptional regulator."},{"id":"ENSMUSP00000128152","abundance":1.61,"rank":9223,"name":"Jade1","annotation":"Protein Jade-1; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator, it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (By similarity). Belongs to the JADE family."},{"id":"ENSMUSP00000102400","abundance":1.61,"rank":9224,"name":"Lexm","annotation":"Lymphocyte expansion molecule."},{"id":"ENSMUSP00000038061","abundance":1.61,"rank":9225,"name":"Fn3krp","annotation":"Ketosamine-3-kinase; Ketosamine-3-kinase involved in protein deglycation by mediating phosphorylation of ribuloselysine and psicoselysine on glycated proteins, to generate ribuloselysine-3 phosphate and psicoselysine-3 phosphate, respectively. Ribuloselysine-3 phosphate and psicoselysine-3 phosphate adducts are unstable and decompose under physiological conditions. Not able to phosphorylate fructoselysine ; Belongs to the fructosamine kinase family."},{"id":"ENSMUSP00000000314","abundance":1.61,"rank":9226,"name":"Cdh4","annotation":"Cadherin-4; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development."},{"id":"ENSMUSP00000056039","abundance":1.61,"rank":9227,"name":"Yipf6","annotation":"Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression."},{"id":"ENSMUSP00000030451","abundance":1.61,"rank":9228,"name":"Toe1","annotation":"Target of EGR1 protein 1; Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1. Involved in the maturation of snRNAs and snRNA 3'-tail processing; Belongs to the CAF1 family."},{"id":"ENSMUSP00000054718","abundance":1.61,"rank":9229,"name":"Fbxo28","annotation":"F-box only protein 28; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation."},{"id":"ENSMUSP00000079860","abundance":1.61,"rank":9230,"name":"4932411N23Rik","annotation":"RIKEN cDNA 4932411N23 gene."},{"id":"ENSMUSP00000058651","abundance":1.61,"rank":9231,"name":"Foxi1","annotation":"Forkhead box protein I1; Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules."},{"id":"ENSMUSP00000070037","abundance":1.61,"rank":9232,"name":"Alkal2","annotation":"ALK and LTK ligand 2; Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation; Belongs to the FAM150 family."},{"id":"ENSMUSP00000056475","abundance":1.61,"rank":9233,"name":"Ftdc","annotation":"Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation."},{"id":"ENSMUSP00000033570","abundance":1.61,"rank":9234,"name":"Igbp1","annotation":"Immunoglobulin-binding protein 1; Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits; Belongs to the IGBP1/TAP42 family."},{"id":"ENSMUSP00000035808","abundance":1.61,"rank":9235,"name":"Ubd","annotation":"Ubiquitin D; Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated- I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelia [...] "},{"id":"ENSMUSP00000125251","abundance":1.61,"rank":9236,"name":"Nos1ap","annotation":"Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity)."},{"id":"ENSMUSP00000105045","abundance":1.6,"rank":9237,"name":"Fitm2","annotation":"Fat storage-inducing transmembrane protein 2; Plays an important role in lipid droplet accumulation. Plays a role in the regulation of cell morphology and cytoskeletal organization."},{"id":"ENSMUSP00000137732","abundance":1.6,"rank":9238,"name":"Foxl1","annotation":"Forkhead box protein L1; Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors."},{"id":"ENSMUSP00000026989","abundance":1.6,"rank":9239,"name":"4833439L19Rik","annotation":"Putative monooxygenase p33MONOX; Potential NADPH-dependent oxidoreductase. May be involved in the regulation of neuronal survival, differentiation and axonal outgrowth (By similarity)."},{"id":"ENSMUSP00000026555","abundance":1.6,"rank":9240,"name":"Odf3","annotation":"Outer dense fiber protein 3; Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail; Belongs to the ODF3 family."},{"id":"ENSMUSP00000110748","abundance":1.6,"rank":9241,"name":"Plxna4","annotation":"Plexin-A4; Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm."},{"id":"ENSMUSP00000072847","abundance":1.6,"rank":9242,"name":"Olfr675","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000010736","abundance":1.6,"rank":9243,"name":"Dazl","annotation":"Deleted in azoospermia-like; RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts."},{"id":"ENSMUSP00000103403","abundance":1.6,"rank":9244,"name":"Kcna7","annotation":"Potassium voltage-gated channel subfamily A member 7; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Channels formed by isoform 1 inactivate faster than channels formed by isoform 2. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.7/KCNA7 sub-subfamily."},{"id":"ENSMUSP00000034910","abundance":1.6,"rank":9245,"name":"Mlip","annotation":"Muscular LMNA-interacting protein; Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD."},{"id":"ENSMUSP00000153101","abundance":1.6,"rank":9246,"name":"Ctsm","annotation":"Cathepsin M."},{"id":"ENSMUSP00000054283","abundance":1.6,"rank":9247,"name":"Ccdc187","annotation":"Coiled-coil domain-containing protein 187."},{"id":"ENSMUSP00000096148","abundance":1.6,"rank":9248,"name":"Scn1b","annotation":"Sodium channel subunit beta-1; Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain, heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits, such as SCN1A, SCN2A, SCN3A, SCN4A, SCN5A and SCN10A; Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family."},{"id":"ENSMUSP00000040001","abundance":1.6,"rank":9249,"name":"Traip","annotation":"E3 ubiquitin-protein ligase TRAIP; E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (By similarity). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV- ind [...] "},{"id":"ENSMUSP00000142498","abundance":1.6,"rank":9250,"name":"Lrrc7","annotation":"Leucine-rich repeat-containing protein 7; Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression."},{"id":"ENSMUSP00000087544","abundance":1.6,"rank":9251,"name":"Gnb1l","annotation":"Guanine nucleotide-binding protein subunit beta-like protein 1."},{"id":"ENSMUSP00000065715","abundance":1.6,"rank":9252,"name":"Fate1","annotation":"Fetal and adult testis-expressed transcript protein homolog; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling."},{"id":"ENSMUSP00000018685","abundance":1.6,"rank":9253,"name":"Cwc25","annotation":"Pre-mRNA-splicing factor CWC25 homolog; Involved in pre-mRNA splicing as component of the spliceosome; Belongs to the CWC25 family."},{"id":"ENSMUSP00000014694","abundance":1.6,"rank":9254,"name":"Rbsn","annotation":"Rabenosyn-5; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane (By similarity)."},{"id":"ENSMUSP00000044075","abundance":1.59,"rank":9255,"name":"Pus7l","annotation":"Pseudouridylate synthase 7 homolog-like protein; Pseudouridylate synthase that catalyzes pseudouridylation of RNAs; Belongs to the pseudouridine synthase TruD family."},{"id":"ENSMUSP00000048730","abundance":1.59,"rank":9256,"name":"Zcwpw1","annotation":"Zinc finger CW-type PWWP domain protein 1."},{"id":"ENSMUSP00000080966","abundance":1.59,"rank":9257,"name":"Samt2b","annotation":"Spermatogenesis-associated multipass transmembrane protein 2b."},{"id":"ENSMUSP00000121266","abundance":1.59,"rank":9258,"name":"Tab2","annotation":"TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187' (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus. Involved in heart development (By similarity)."},{"id":"ENSMUSP00000075621","abundance":1.59,"rank":9259,"name":"Abca15","annotation":"ATP-binding cassette transporter sub-family A member 15."},{"id":"ENSMUSP00000037055","abundance":1.59,"rank":9260,"name":"Trim41","annotation":"E3 ubiquitin-protein ligase TRIM41; Functions as an E3 ligase that catalyzes the ubiquitin- mediated degradation of protein kinase C. Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000147989","abundance":1.59,"rank":9261,"name":"Arntl","annotation":"Aryl hydrocarbon receptor nuclear translocator-like protein 1; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...] "},{"id":"ENSMUSP00000066554","abundance":1.59,"rank":9262,"name":"Epha3","annotation":"Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] "},{"id":"ENSMUSP00000037168","abundance":1.59,"rank":9263,"name":"Cuzd1","annotation":"CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes (By similarity). May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells."},{"id":"ENSMUSP00000093878","abundance":1.59,"rank":9264,"name":"Fam189a2","annotation":"Protein FAM189A2; Belongs to the FAM189 family."},{"id":"ENSMUSP00000131058","abundance":1.59,"rank":9265,"name":"Cyp4f16","annotation":"Cytochrome P450, family 4, subfamily f, polypeptide 16; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000058522","abundance":1.59,"rank":9266,"name":"Spesp1","annotation":"Sperm equatorial segment protein 1; Involved in fertilization ability of sperm."},{"id":"ENSMUSP00000087656","abundance":1.59,"rank":9267,"name":"Hic2","annotation":"Hypermethylated in cancer 2 protein; Transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily."},{"id":"ENSMUSP00000073221","abundance":1.59,"rank":9268,"name":"Zar1","annotation":"Zygote arrest protein 1; Essential for female fertility. May play a role in the oocyte-to-embryo transition; Belongs to the ZAR1 family."},{"id":"ENSMUSP00000158756","abundance":1.59,"rank":9269,"name":"Cldn34a","annotation":"Claudin 34A."},{"id":"ENSMUSP00000043120","abundance":1.59,"rank":9270,"name":"Rbm24","annotation":"RNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] "},{"id":"ENSMUSP00000041663","abundance":1.59,"rank":9271,"name":"Chst12","annotation":"Carbohydrate sulfotransferase 12; Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of chondroitin and desulfated dermatan sulfate. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Activity toward partially desulfated dermatan sulfate is however lower. Does not form 4, 6-di-O- sulfated GalNAc when chondroitin sulfate C is used as an acceptor (By similarity)."},{"id":"ENSMUSP00000037120","abundance":1.59,"rank":9272,"name":"Nexn","annotation":"Nexilin; Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity."},{"id":"ENSMUSP00000114588","abundance":1.59,"rank":9273,"name":"Pus7","annotation":"Pseudouridylate synthase 7 homolog; Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudour [...] "},{"id":"ENSMUSP00000029105","abundance":1.59,"rank":9274,"name":"Zgpat","annotation":"Zinc finger CCCH-type with G patch domain-containing protein; Transcription repressor that specifically binds the 5'- GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity)."},{"id":"ENSMUSP00000102034","abundance":1.59,"rank":9275,"name":"Synpo2","annotation":"Synaptopodin-2; Has an actin-binding and actin-bundling activity. Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing a [...] "},{"id":"ENSMUSP00000041378","abundance":1.59,"rank":9276,"name":"Shtn1","annotation":"Shootin-1; Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Pla [...] "},{"id":"ENSMUSP00000020576","abundance":1.59,"rank":9277,"name":"Ccng1","annotation":"Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation. Belongs to the cyclin family. Cyclin G subfamily."},{"id":"ENSMUSP00000149748","abundance":1.59,"rank":9278,"name":"Ubl7","annotation":"Ubiquitin-like protein 7."},{"id":"ENSMUSP00000123494","abundance":1.59,"rank":9279,"name":"Tmem44","annotation":"Transmembrane protein 44."},{"id":"ENSMUSP00000111349","abundance":1.59,"rank":9280,"name":"Aifm3","annotation":"Apoptosis-inducing factor 3; Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential (By similarity)."},{"id":"ENSMUSP00000040935","abundance":1.59,"rank":9281,"name":"Sdhaf3","annotation":"Succinate dehydrogenase assembly factor 3, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit Sdhb of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1."},{"id":"ENSMUSP00000046229","abundance":1.58,"rank":9282,"name":"Btnl9","annotation":"Butyrophilin-like protein 9; Belongs to the immunoglobulin superfamily. BTN/MOG family."},{"id":"ENSMUSP00000080571","abundance":1.58,"rank":9283,"name":"4930512M02Rik","annotation":"RIKEN cDNA 4930512M02 gene."},{"id":"ENSMUSP00000021991","abundance":1.58,"rank":9284,"name":"Mterf3","annotation":"Transcription termination factor 3, mitochondrial; Binds promoter DNA and regulates initiation of transcription (By similarity). Required for normal mitochondrial transcription and translation, and for normal assembly of mitochondrial respiratory complexes. Required for normal mitochondrial function. Maintains 16S rRNA levels and functions in mitochondrial ribosome assembly by regulating the biogenesis of the 39S ribosomal subunit ; Belongs to the mTERF family."},{"id":"ENSMUSP00000099752","abundance":1.58,"rank":9285,"name":"Cdca7","annotation":"Cell division cycle-associated protein 7; Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity)."},{"id":"ENSMUSP00000047639","abundance":1.58,"rank":9286,"name":"Mical2","annotation":"[F-actin]-monooxygenase MICAL2; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promo [...] "},{"id":"ENSMUSP00000101713","abundance":1.58,"rank":9287,"name":"Rab40b","annotation":"Ras-related protein Rab-40B; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000059180","abundance":1.58,"rank":9288,"name":"Pcdhb3","annotation":"Protocadherin beta 3."},{"id":"ENSMUSP00000033057","abundance":1.58,"rank":9289,"name":"Dkkl1","annotation":"Dickkopf-like protein 1; Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promote spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduce testosterone synthesis in Leydig cells. Is not essential either for development or fertility."},{"id":"ENSMUSP00000061308","abundance":1.58,"rank":9290,"name":"Tpcn2","annotation":"Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. Involved in smooth muscle contraction; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily."},{"id":"ENSMUSP00000128029","abundance":1.58,"rank":9291,"name":"Sugp2","annotation":"SURP and G-patch domain-containing protein 2; May play a role in mRNA splicing."},{"id":"ENSMUSP00000030782","abundance":1.58,"rank":9292,"name":"Hes2","annotation":"Transcription factor HES-2; Transcriptional repressor of genes that require a bHLH protein for their transcription."},{"id":"ENSMUSP00000023295","abundance":1.58,"rank":9293,"name":"Acr","annotation":"Acrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000045241","abundance":1.58,"rank":9294,"name":"Oscp1","annotation":"Protein OSCP1; May be involved in drug clearance in the placenta."},{"id":"ENSMUSP00000153261","abundance":1.58,"rank":9295,"name":"Dsc3","annotation":"Desmocollin-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms."},{"id":"ENSMUSP00000052559","abundance":1.58,"rank":9296,"name":"Dlx5","annotation":"Homeobox protein DLX-5; Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL an [...] "},{"id":"ENSMUSP00000034776","abundance":1.58,"rank":9297,"name":"Cln6","annotation":"Ceroid-lipofuscinosis, neuronal 6."},{"id":"ENSMUSP00000103571","abundance":1.58,"rank":9298,"name":"Shank1","annotation":"SH3 and multiple ankyrin repeat domains protein 1; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Overexpression promotes maturation of dendritic spines and the enlargement of spine heads via its ability to recruit Homer to postsynaptic sites, and enhances presynaptic function (By similarity); B [...] "},{"id":"ENSMUSP00000022153","abundance":1.58,"rank":9299,"name":"Ptcd2","annotation":"Pentatricopeptide repeat-containing protein 2, mitochondrial; Involved in mitochondrial RNA maturation and mitochondrial respiratory chain function; Belongs to the PTCD2 family."},{"id":"ENSMUSP00000047562","abundance":1.58,"rank":9300,"name":"Trappc11","annotation":"Trafficking protein particle complex subunit 11; Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage; Belongs to the TRAPPC11 family."},{"id":"ENSMUSP00000039429","abundance":1.58,"rank":9301,"name":"Dpyd","annotation":"Dihydropyrimidine dehydrogenase [NADP(+)]; Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity)."},{"id":"ENSMUSP00000001700","abundance":1.57,"rank":9302,"name":"Hoxc13","annotation":"Homeobox protein Hox-C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair- specific genes."},{"id":"ENSMUSP00000032796","abundance":1.57,"rank":9303,"name":"Zfp790","annotation":"Zinc finger protein 790."},{"id":"ENSMUSP00000034787","abundance":1.57,"rank":9304,"name":"Phip","annotation":"PH-interacting protein; Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization."},{"id":"ENSMUSP00000077423","abundance":1.57,"rank":9305,"name":"Rasal2","annotation":"RAS protein activator-like 2."},{"id":"ENSMUSP00000103064","abundance":1.57,"rank":9306,"name":"Gm11595","annotation":"Predicted gene 11595."},{"id":"ENSMUSP00000107656","abundance":1.57,"rank":9307,"name":"2310009B15Rik","annotation":"RIKEN cDNA 2310009B15 gene."},{"id":"ENSMUSP00000111086","abundance":1.57,"rank":9308,"name":"Steap2","annotation":"Metalloreductase STEAP2; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family."},{"id":"ENSMUSP00000048810","abundance":1.57,"rank":9309,"name":"Hspb11","annotation":"Intraflagellar transport protein 25 homolog; Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male ferti [...] "},{"id":"ENSMUSP00000038909","abundance":1.57,"rank":9310,"name":"Cspg4","annotation":"Chondroitin sulfate proteoglycan 4; Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma ce [...] "},{"id":"ENSMUSP00000051080","abundance":1.57,"rank":9311,"name":"Eml6","annotation":"Echinoderm microtubule-associated protein-like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family."},{"id":"ENSMUSP00000150163","abundance":1.57,"rank":9312,"name":"Gm49337","annotation":"Predicted gene, 49337."},{"id":"ENSMUSP00000056353","abundance":1.57,"rank":9313,"name":"Tmtc1","annotation":"Protein O-mannosyl-transferase TMTC1; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3."},{"id":"ENSMUSP00000140127","abundance":1.57,"rank":9314,"name":"Neu4","annotation":"Sialidase-4; May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4- MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids (By similarity)."},{"id":"ENSMUSP00000095979","abundance":1.57,"rank":9315,"name":"Slc26a6","annotation":"Solute carrier family 26 member 6; Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS- sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate- sulfate and chloride- [...] "},{"id":"ENSMUSP00000022217","abundance":1.57,"rank":9316,"name":"Zfyve16","annotation":"Zinc finger FYVE domain-containing protein 16; May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes (By similarity)."},{"id":"ENSMUSP00000056705","abundance":1.57,"rank":9317,"name":"Galnt6","annotation":"Polypeptide N-acetylgalactosaminyltransferase 6; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. May participate in synthesis of oncofetal fibronectin. Has activity toward Muc1a, Muc2, EA2 and fibronectin peptides (By similarity); Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily."},{"id":"ENSMUSP00000090327","abundance":1.57,"rank":9318,"name":"Taar7d","annotation":"Trace amine-associated receptor 7d; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000027830","abundance":1.57,"rank":9319,"name":"Slamf9","annotation":"SLAM family member 9; May play a role in the immune response."},{"id":"ENSMUSP00000140784","abundance":1.57,"rank":9320,"name":"Krtap5-2","annotation":"Keratin-associated protein 5-2; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family."},{"id":"ENSMUSP00000134759","abundance":1.57,"rank":9321,"name":"Traf7","annotation":"E3 ubiquitin-protein ligase TRAF7; E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3."},{"id":"ENSMUSP00000016088","abundance":1.56,"rank":9322,"name":"Castor2","annotation":"Cytosolic arginine sensor for mTORC1 subunit 2; Functions as a negative regulator of the TORC1 signaling pathway through the GATOR complex. As part of homodimers or heterodimers with CASTOR1, directly binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Does not directly bind arginine, but binding of arginine to CASTOR1 disrupts the interaction of CASTOR2- containing heterodimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway."},{"id":"ENSMUSP00000097108","abundance":1.56,"rank":9323,"name":"Kcnj6","annotation":"G protein-activated inward rectifier potassium channel 2; This potassium channel is controlled by G proteins. It plays a role in granule cell differentiation, possibly via membrane hyperpolarization. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of [...] "},{"id":"ENSMUSP00000125322","abundance":1.56,"rank":9324,"name":"Cdk5r2","annotation":"Cyclin-dependent kinase 5 activator 2; Activator of CDK5/TPKII; Belongs to the cyclin-dependent kinase 5 activator family."},{"id":"ENSMUSP00000072983","abundance":1.56,"rank":9325,"name":"Chrnd","annotation":"Acetylcholine receptor subunit delta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane."},{"id":"ENSMUSP00000147863","abundance":1.56,"rank":9326,"name":"Gm4553","annotation":"Predicted gene 4553."},{"id":"ENSMUSP00000056552","abundance":1.56,"rank":9327,"name":"Kcng4","annotation":"Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily."},{"id":"ENSMUSP00000143657","abundance":1.56,"rank":9328,"name":"Nub1","annotation":"NEDD8 ultimate buster 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation (By similarity)."},{"id":"ENSMUSP00000106420","abundance":1.56,"rank":9329,"name":"Rpap1","annotation":"RNA polymerase II-associated protein 1; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Required for interaction of the RNA polymerase II complex with acetylated histone H3 (By similarity); Belongs to the RPAP1 family."},{"id":"ENSMUSP00000034408","abundance":1.56,"rank":9330,"name":"Gpr83","annotation":"Probable G-protein coupled receptor 83; Orphan receptor. Could be a neuropeptide Y receptor."},{"id":"ENSMUSP00000151069","abundance":1.56,"rank":9331,"name":"Olfr134","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000028403","abundance":1.56,"rank":9332,"name":"Cybrd1","annotation":"Cytochrome b reductase 1; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+). Present at the brush border of duodenal enterocytes where it probably reduces dietary Fe(3+) thereby facilitating its transport into the mucosal cells. Uses ascorbate as electron donor. May be involved in extracellular ascorbate recycling in erythrocyte membranes. May also act as a ferrireductase in airway epithelial cells."},{"id":"ENSMUSP00000046137","abundance":1.56,"rank":9333,"name":"Tcaf1","annotation":"TRPM8 channel-associated factor 1; Positively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration inhibition in a TRPM8-dependent manner."},{"id":"ENSMUSP00000127247","abundance":1.56,"rank":9334,"name":"Olfr1564","annotation":"Olfactory receptor 1564."},{"id":"ENSMUSP00000027559","abundance":1.56,"rank":9335,"name":"Tnfrsf11a","annotation":"Tumor necrosis factor receptor superfamily member 11A; Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL- mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells."},{"id":"ENSMUSP00000124462","abundance":1.56,"rank":9336,"name":"Kif26b","annotation":"Kinesin-like protein KIF26B; Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. K [...] "},{"id":"ENSMUSP00000068792","abundance":1.56,"rank":9337,"name":"Khdc1c","annotation":"KH homology domain-containing protein 1C; Belongs to the KHDC1 family."},{"id":"ENSMUSP00000085749","abundance":1.56,"rank":9338,"name":"Khdc1a","annotation":"KH homology domain-containing protein 1A; Has pro-apoptotic activity."},{"id":"ENSMUSP00000072527","abundance":1.56,"rank":9339,"name":"Vipas39","annotation":"Spermatogenesis-defective protein 39 homolog; Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (By similarity). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in [...] "},{"id":"ENSMUSP00000054864","abundance":1.56,"rank":9340,"name":"Olfr866","annotation":"Olfactory receptor MOR145-5."},{"id":"ENSMUSP00000085862","abundance":1.56,"rank":9341,"name":"Dnase1l2","annotation":"Deoxyribonuclease-1-like 2; Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells (By similarity)."},{"id":"ENSMUSP00000027521","abundance":1.56,"rank":9342,"name":"Agap1","annotation":"Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1; GTPase-activating protein for ARF1 and, to a lesser extent, ARF5. Directly and specifically regulates the adapter protein 3 (AP-3)- dependent trafficking of proteins in the endosomal-lysosomal system (By similarity); Belongs to the centaurin gamma-like family."},{"id":"ENSMUSP00000097538","abundance":1.56,"rank":9343,"name":"Fam89b","annotation":"Leucine repeat adapter protein 25; Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. Belongs to the FAM89 family."},{"id":"ENSMUSP00000073855","abundance":1.56,"rank":9344,"name":"Synm","annotation":"Synemin; Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells (By similarity)."},{"id":"ENSMUSP00000025645","abundance":1.56,"rank":9345,"name":"Tmem132a","annotation":"Transmembrane protein 132A; May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity)."},{"id":"ENSMUSP00000109078","abundance":1.56,"rank":9346,"name":"Slc22a12","annotation":"Solute carrier family 22 member 12; Required for efficient urate re-absorption in the kidney. Regulates blood urate levels. Mediates saturable urate uptake by facilitating the exchange of urate against organic anions or chloride ions."},{"id":"ENSMUSP00000124369","abundance":1.55,"rank":9347,"name":"Ttc26","annotation":"Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI2 and GLI3 at the ciliary tips and their dissociation from the negative regulator SUFU. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT compl [...] "},{"id":"ENSMUSP00000053551","abundance":1.55,"rank":9348,"name":"Fzd9","annotation":"Frizzled-9; Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway. May play a role in neural progenitor cells (NPCs) viability through the beta- catenin canonical signaling pathway by negatively regulating cell  [...] "},{"id":"ENSMUSP00000064986","abundance":1.55,"rank":9349,"name":"Synpr","annotation":"Synaptoporin; Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity)."},{"id":"ENSMUSP00000027226","abundance":1.55,"rank":9350,"name":"Khdrbs2","annotation":"KH domain-containing, RNA-binding, signal transduction-associated protein 2; RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion (By similarity). Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Induces an increased concentration-dependent incorporation of exon in CD44 pre- mRNA by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the ev [...] "},{"id":"ENSMUSP00000081545","abundance":1.55,"rank":9351,"name":"Pappa","annotation":"Pappalysin-1; Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Isoform 2 cleaves IGFBP-4 very slowly compared to PAPP-A, but its ability to cleave IGFBP-5 is unaffected."},{"id":"ENSMUSP00000087479","abundance":1.55,"rank":9352,"name":"Aard","annotation":"Alanine and arginine-rich domain-containing protein."},{"id":"ENSMUSP00000112946","abundance":1.55,"rank":9353,"name":"Rtkn2","annotation":"Rhotekin-2; May play an important role in lymphopoiesis."},{"id":"ENSMUSP00000079095","abundance":1.55,"rank":9354,"name":"Sp140","annotation":"Sp140 nuclear body protein."},{"id":"ENSMUSP00000137526","abundance":1.55,"rank":9355,"name":"Rhox5","annotation":"Homeobox protein Rhox5; Transcription factor required for differentiation of embryonic stem cells (ESCs) into primordial germ cells."},{"id":"ENSMUSP00000150698","abundance":1.55,"rank":9356,"name":"Olfr877","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000064467","abundance":1.55,"rank":9357,"name":"Rimklb","annotation":"Beta-citrylglutamate synthase B; Catalyzes the synthesis of beta-citryl-L-glutamate and N- acetyl-L-aspartyl-L-glutamate. Beta-citryl-L-glutamate is synthesized more efficiently than N-acetyl-L-aspartyl-L-glutamate. Belongs to the RimK family."},{"id":"ENSMUSP00000139949","abundance":1.55,"rank":9358,"name":"Glce","annotation":"D-glucuronyl C5-epimerase; Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins. Belongs to the D-glucuronyl C5-epimerase family."},{"id":"ENSMUSP00000096415","abundance":1.55,"rank":9359,"name":"Vps37a","annotation":"Vacuolar protein sorting-associated protein 37A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity); Belongs to the VPS37 family."},{"id":"ENSMUSP00000131423","abundance":1.55,"rank":9360,"name":"Snx24","annotation":"Sorting nexin-24; May be involved in several stages of intracellular trafficking."},{"id":"ENSMUSP00000066662","abundance":1.55,"rank":9361,"name":"Trim50","annotation":"E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction."},{"id":"ENSMUSP00000004943","abundance":1.55,"rank":9362,"name":"Tmed11","annotation":"Transmembrane emp24 domain-containing protein 11; Part of a complex whose function is to bind Ca(2+) to the ER membrane and thereby regulate the retention of ER resident proteins. Belongs to the EMP24/GP25L family."},{"id":"ENSMUSP00000158437","abundance":1.55,"rank":9363,"name":"Tbc1d10c","annotation":"Carabin; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras (By similarity)."},{"id":"ENSMUSP00000114397","abundance":1.55,"rank":9364,"name":"Fam83e","annotation":"Protein FAM83E; May play a role in MAPK signaling. Belongs to the FAM83 family."},{"id":"ENSMUSP00000030568","abundance":1.55,"rank":9365,"name":"Sema3c","annotation":"Semaphorin-3C; Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance."},{"id":"ENSMUSP00000000834","abundance":1.55,"rank":9366,"name":"Fasl","annotation":"Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarit [...] "},{"id":"ENSMUSP00000009340","abundance":1.55,"rank":9367,"name":"Ifi211","annotation":"Interferon-activable protein 205-B; May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways; Belongs to the HIN-200 family."},{"id":"ENSMUSP00000109881","abundance":1.55,"rank":9368,"name":"Gm973","annotation":"Predicted gene 973."},{"id":"ENSMUSP00000029671","abundance":1.54,"rank":9369,"name":"Ifi44","annotation":"Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family."},{"id":"ENSMUSP00000113457","abundance":1.54,"rank":9370,"name":"Ccdc186","annotation":"Coiled-coil domain-containing protein 186."},{"id":"ENSMUSP00000067114","abundance":1.54,"rank":9371,"name":"Slc22a28","annotation":"Solute carrier family 22, member 28."},{"id":"ENSMUSP00000009713","abundance":1.54,"rank":9372,"name":"Mrtfb","annotation":"Myocardin-related transcription factor B; Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation."},{"id":"ENSMUSP00000040380","abundance":1.54,"rank":9373,"name":"Gm5617","annotation":"Uncharacterized protein C11orf71 homolog."},{"id":"ENSMUSP00000127192","abundance":1.54,"rank":9374,"name":"Rfx7","annotation":"Regulatory factor X, 7."},{"id":"ENSMUSP00000035802","abundance":1.54,"rank":9375,"name":"Col16a1","annotation":"Collagen alpha-1(XVI) chain; Involved in mediating cell attachment and inducing integrin- mediated cellular reactions, such as cell spreading and alterations in cell morphology."},{"id":"ENSMUSP00000096950","abundance":1.54,"rank":9376,"name":"Hspa12b","annotation":"Heat shock 70 kDa protein 12B."},{"id":"ENSMUSP00000023673","abundance":1.54,"rank":9377,"name":"Runx1","annotation":"Runt-related transcription factor 1; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T [...] "},{"id":"ENSMUSP00000106380","abundance":1.54,"rank":9378,"name":"Defa42","annotation":"Defensin, alpha, 42."},{"id":"ENSMUSP00000106377","abundance":1.54,"rank":9379,"name":"Defa43","annotation":"Defensin, alpha, 42."},{"id":"ENSMUSP00000146286","abundance":1.54,"rank":9380,"name":"Zfp626","annotation":"Zinc finger protein 626."},{"id":"ENSMUSP00000043616","abundance":1.54,"rank":9381,"name":"Lmx1b","annotation":"LIM homeobox transcription factor 1-beta; Essential for the specification of dorsal limb fate at both the zeugopodal and autopodal levels."},{"id":"ENSMUSP00000149879","abundance":1.54,"rank":9382,"name":"Hinfp","annotation":"Histone H4 transcription factor; Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter."},{"id":"ENSMUSP00000021738","abundance":1.54,"rank":9383,"name":"Gpr137b","annotation":"Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] "},{"id":"ENSMUSP00000082691","abundance":1.54,"rank":9384,"name":"Utp25","annotation":"Digestive organ expansion factor homolog; Regulates the p53 pathway to control the expansion growth of digestive organs; Belongs to the def family."},{"id":"ENSMUSP00000029911","abundance":1.54,"rank":9385,"name":"Pnisr","annotation":"Arginine/serine-rich protein PNISR; Belongs to the splicing factor SR family."},{"id":"ENSMUSP00000059780","abundance":1.54,"rank":9386,"name":"Ivl","annotation":"Involucrin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia."},{"id":"ENSMUSP00000113810","abundance":1.54,"rank":9387,"name":"Pld1","annotation":"Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic."},{"id":"ENSMUSP00000113353","abundance":1.54,"rank":9388,"name":"Cox18","annotation":"Cytochrome c oxidase assembly protein COX18, mitochondrial; Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT- CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT- CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase)."},{"id":"ENSMUSP00000026562","abundance":1.54,"rank":9389,"name":"Ifitm5","annotation":"Interferon-induced transmembrane protein 5; Required for normal bone mineralization."},{"id":"ENSMUSP00000110975","abundance":1.54,"rank":9390,"name":"Zfp800","annotation":"Zinc finger protein 800; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000029213","abundance":1.54,"rank":9391,"name":"Ocstamp","annotation":"Osteoclast stimulatory transmembrane protein; Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation."},{"id":"ENSMUSP00000057157","abundance":1.54,"rank":9392,"name":"Mageh1","annotation":"Melanoma-associated antigen H1."},{"id":"ENSMUSP00000112988","abundance":1.54,"rank":9393,"name":"Abhd17c","annotation":"Alpha/beta hydrolase domain-containing protein 17C; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards DLG4/PSD95. Belongs to the AB hydrolase superfamily. ABHD17 family."},{"id":"ENSMUSP00000128473","abundance":1.54,"rank":9394,"name":"Clnk","annotation":"Cytokine-dependent hematopoietic cell linker; An adapter protein which plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Together with FGR, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production. Acts as a positive regulator of both T-cell receptor and natural killer T (NKT) cell receptor signaling in CD4-positive NKT cells. Together with MAP4K1, it enhances CD3-triggered activation of T-cells an [...] "},{"id":"ENSMUSP00000099601","abundance":1.54,"rank":9395,"name":"Dph6","annotation":"Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor 2 (EEF2) to diphthamide (By similarity). Belongs to the Diphthine--ammonia ligase family."},{"id":"ENSMUSP00000033752","abundance":1.54,"rank":9396,"name":"Slc6a8","annotation":"Sodium- and chloride-dependent creatine transporter 1; Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier."},{"id":"ENSMUSP00000043659","abundance":1.54,"rank":9397,"name":"Tmem59l","annotation":"Transmembrane protein 59-like; Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of APP. Inhibits APP transport to the cell surface and further shedding (By similarity). Belongs to the TMEM59 family."},{"id":"ENSMUSP00000035009","abundance":1.53,"rank":9398,"name":"Cmtm7","annotation":"CKLF-like MARVEL transmembrane domain-containing protein 7; Belongs to the chemokine-like factor family."},{"id":"ENSMUSP00000132491","abundance":1.53,"rank":9399,"name":"Gm3095","annotation":"Predicted gene 3095."},{"id":"ENSMUSP00000036996","abundance":1.53,"rank":9400,"name":"Man1b1","annotation":"Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity); Belongs to the glycosyl hydrolase 47 family."},{"id":"ENSMUSP00000031256","abundance":1.53,"rank":9401,"name":"Aff1","annotation":"AF4/FMR2 family member 1; Belongs to the AF4 family."},{"id":"ENSMUSP00000078572","abundance":1.53,"rank":9402,"name":"Tor3a","annotation":"Torsin-3A."},{"id":"ENSMUSP00000103839","abundance":1.53,"rank":9403,"name":"Fhl5","annotation":"Four and a half LIM domains protein 5; May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation- independent manner (By similarity)."},{"id":"ENSMUSP00000044231","abundance":1.53,"rank":9404,"name":"Naaladl1","annotation":"Aminopeptidase NAALADL1; Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position. Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity."},{"id":"ENSMUSP00000048427","abundance":1.53,"rank":9405,"name":"Mustn1","annotation":"Musculoskeletal embryonic nuclear protein 1; May be involved in the development and regeneration of the musculoskeletal system; Belongs to the MUSTANG family."},{"id":"ENSMUSP00000031680","abundance":1.53,"rank":9406,"name":"Ing3","annotation":"Inhibitor of growth protein 3; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicat [...] "},{"id":"ENSMUSP00000031654","abundance":1.53,"rank":9407,"name":"Pomp","annotation":"Proteasome maturation protein; Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation (By similarity). Mediates the association of 20S preproteasome with the endoplasmic reticulum (By similarity)."},{"id":"ENSMUSP00000058732","abundance":1.53,"rank":9408,"name":"Rxfp4","annotation":"Relaxin-3 receptor 2; High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity)."},{"id":"ENSMUSP00000022476","abundance":1.53,"rank":9409,"name":"Glt8d1","annotation":"Glycosyltransferase 8 domain-containing protein 1; Belongs to the glycosyltransferase 8 family."},{"id":"ENSMUSP00000075599","abundance":1.53,"rank":9410,"name":"Ifit3b","annotation":"Interferon-induced protein with tetratricopeptide repeats 3B."},{"id":"ENSMUSP00000132436","abundance":1.53,"rank":9411,"name":"Zfp488","annotation":"Zinc finger protein 488; Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury."},{"id":"ENSMUSP00000023133","abundance":1.53,"rank":9412,"name":"Ppp1r1a","annotation":"Protein phosphatase 1 regulatory subunit 1A; Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases."},{"id":"ENSMUSP00000060941","abundance":1.53,"rank":9413,"name":"Rnf214","annotation":"RING finger protein 214."},{"id":"ENSMUSP00000153157","abundance":1.53,"rank":9414,"name":"Atp9b","annotation":"Probable phospholipid-transporting ATPase IIB; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily."},{"id":"ENSMUSP00000021891","abundance":1.53,"rank":9415,"name":"Cts8","annotation":"Cathepsin 8; Probable protease (By similarity). In placenta, plays a role in promoting giant cell differentiation. Also plays a role in placental spiral artery remodeling by direct degradation of smooth muscle alpha-actin. Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000110809","abundance":1.53,"rank":9416,"name":"Rhox7b","annotation":"Reproductive homeobox 7B."},{"id":"ENSMUSP00000101536","abundance":1.53,"rank":9417,"name":"Ahdc1","annotation":"AT-hook DNA-binding motif-containing protein 1."},{"id":"ENSMUSP00000049694","abundance":1.53,"rank":9418,"name":"Fam243","annotation":"Protein FAM243A; Belongs to the FAM243 family."},{"id":"ENSMUSP00000123525","abundance":1.53,"rank":9419,"name":"Ablim2","annotation":"Actin-binding LIM protein 2; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity."},{"id":"ENSMUSP00000036772","abundance":1.52,"rank":9420,"name":"Gdpd4","annotation":"Glycerophosphodiester phosphodiesterase domain-containing protein 4; Belongs to the glycerophosphoryl diester phosphodiesterase family."},{"id":"ENSMUSP00000081696","abundance":1.52,"rank":9421,"name":"Spag8","annotation":"Sperm-associated antigen 8; Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5- regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity)."},{"id":"ENSMUSP00000063335","abundance":1.52,"rank":9422,"name":"Rcor2","annotation":"REST corepressor 2; May act as a component of a corepressor complex that represses transcription."},{"id":"ENSMUSP00000099628","abundance":1.52,"rank":9423,"name":"Phactr4","annotation":"Phosphatase and actin regulator 4; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to  [...] "},{"id":"ENSMUSP00000029936","abundance":1.52,"rank":9424,"name":"Gbp2b","annotation":"Guanylate-binding protein 1; Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus (By similarity). Promotes oxidative killing and delivers antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily."},{"id":"ENSMUSP00000158312","abundance":1.52,"rank":9425,"name":"Ndst1","annotation":"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate [...] "},{"id":"ENSMUSP00000022535","abundance":1.52,"rank":9426,"name":"Dcp1a","annotation":"mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1 (By similarity)."},{"id":"ENSMUSP00000151138","abundance":1.52,"rank":9427,"name":"Olfr670","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000027139","abundance":1.52,"rank":9428,"name":"Wdr75","annotation":"WD repeat-containing protein 75; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I."},{"id":"ENSMUSP00000091898","abundance":1.52,"rank":9429,"name":"Mkrn3","annotation":"Probable E3 ubiquitin-protein ligase makorin-3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins."},{"id":"ENSMUSP00000032396","abundance":1.52,"rank":9430,"name":"Lrmp","annotation":"Processed lymphoid-restricted membrane protein; Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Belongs to the LRMP family."},{"id":"ENSMUSP00000086311","abundance":1.52,"rank":9431,"name":"Bpifb9b","annotation":"BPI fold-containing family B, member 9B."},{"id":"ENSMUSP00000099667","abundance":1.52,"rank":9432,"name":"AU040320","annotation":"Dyslexia-associated protein KIAA0319-like protein; Possible role in axon guidance through interaction with RTN4R."},{"id":"ENSMUSP00000034469","abundance":1.52,"rank":9433,"name":"Egln1","annotation":"Egl nine homolog 1; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is  [...] "},{"id":"ENSMUSP00000022787","abundance":1.52,"rank":9434,"name":"Slc7a8","annotation":"Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administe [...] "},{"id":"ENSMUSP00000039566","abundance":1.52,"rank":9435,"name":"Pkn2","annotation":"Serine/threonine-protein kinase N2; PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the re [...] "},{"id":"ENSMUSP00000086938","abundance":1.52,"rank":9436,"name":"Cenpb","annotation":"Major centromere autoantigen B; Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes."},{"id":"ENSMUSP00000002444","abundance":1.52,"rank":9437,"name":"Rfx2","annotation":"DNA-binding protein RFX2; Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene HIST1H1T. Belongs to the RFX family."},{"id":"ENSMUSP00000030464","abundance":1.52,"rank":9438,"name":"Pik3r3","annotation":"Phosphatidylinositol 3-kinase regulatory subunit gamma; Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1."},{"id":"ENSMUSP00000027529","abundance":1.52,"rank":9439,"name":"Rab17","annotation":"Ras-related protein Rab-17; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in [...] "},{"id":"ENSMUSP00000035746","abundance":1.52,"rank":9440,"name":"Foxj3","annotation":"Forkhead box protein J3; Transcriptional activator of MEF2C involved in the regulation of adult muscle fiber type identity and skeletal muscle regeneration."},{"id":"ENSMUSP00000028466","abundance":1.52,"rank":9441,"name":"Prg3","annotation":"Proteoglycan 3; Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP."},{"id":"ENSMUSP00000112595","abundance":1.52,"rank":9442,"name":"Sirt1","annotation":"NAD-dependent protein deacetylase sirtuin-1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression (By similarity). Deacetylates a broad range of transcription factors and coregulators, thereby regulating ta [...] "},{"id":"ENSMUSP00000093533","abundance":1.52,"rank":9443,"name":"Prdm15","annotation":"PR domain zinc finger protein 15; Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in th [...] "},{"id":"ENSMUSP00000092414","abundance":1.51,"rank":9444,"name":"Zmynd12","annotation":"Zinc finger, MYND domain-containing 12."},{"id":"ENSMUSP00000052863","abundance":1.51,"rank":9445,"name":"Nfib","annotation":"Nuclear factor 1 B-type; Transcriptional activator of GFAP, essential for proper brain development. Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication."},{"id":"ENSMUSP00000058000","abundance":1.51,"rank":9446,"name":"Mrgpre","annotation":"Mas-related G-protein coupled receptor member E; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily."},{"id":"ENSMUSP00000138388","abundance":1.51,"rank":9447,"name":"Tktl2","annotation":"Transketolase-like protein 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (By similarity)."},{"id":"ENSMUSP00000097328","abundance":1.51,"rank":9448,"name":"Tbc1d32","annotation":"Protein broad-minded; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling."},{"id":"ENSMUSP00000158357","abundance":1.51,"rank":9449,"name":"Msln","annotation":"Megakaryocyte-potentiating factor; Membrane-anchored forms may play a role in cellular adhesion. Belongs to the mesothelin family."},{"id":"ENSMUSP00000149559","abundance":1.51,"rank":9450,"name":"Olfr957","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000033866","abundance":1.51,"rank":9451,"name":"Vps36","annotation":"Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may a [...] "},{"id":"ENSMUSP00000041696","abundance":1.51,"rank":9452,"name":"Kcnj12","annotation":"ATP-sensitive inward rectifier potassium channel 12; Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potas [...] "},{"id":"ENSMUSP00000035584","abundance":1.51,"rank":9453,"name":"Pdia2","annotation":"Protein disulfide-isomerase A2; Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins (By similarity)."},{"id":"ENSMUSP00000084794","abundance":1.51,"rank":9454,"name":"Dido1","annotation":"Death-inducer obliterator 1; Required for early embryonic stem cell development (By similarity). Putative transcription factor, weakly pro-apoptotic when overexpressed."},{"id":"ENSMUSP00000045474","abundance":1.51,"rank":9455,"name":"Atg101","annotation":"Autophagy-related protein 101; Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation."},{"id":"ENSMUSP00000091342","abundance":1.51,"rank":9456,"name":"Myzap","annotation":"Myocardial zonula adherens protein; Plays a role in cellular signaling via Rho-related GTP- binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity). In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1 (By similarity)."},{"id":"ENSMUSP00000114272","abundance":1.51,"rank":9457,"name":"Etnk2","annotation":"Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity."},{"id":"ENSMUSP00000031607","abundance":1.51,"rank":9458,"name":"Dtx1","annotation":"E3 ubiquitin-protein ligase DTX1; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development  [...] "},{"id":"ENSMUSP00000039376","abundance":1.51,"rank":9459,"name":"Exo1","annotation":"Exonuclease 1; 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Es [...] "},{"id":"ENSMUSP00000114765","abundance":1.51,"rank":9460,"name":"Taf1","annotation":"Transcription initiation factor TFIID subunit 1; Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle. Exhibits histone acetyltransferase activity towards histones H3 and H4. Belongs to the TAF1 family."},{"id":"ENSMUSP00000061180","abundance":1.51,"rank":9461,"name":"Lamp5","annotation":"Lysosome-associated membrane glycoprotein 5; Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain; Belongs to the LAMP family."},{"id":"ENSMUSP00000026029","abundance":1.51,"rank":9462,"name":"Samt4","annotation":"Spermatogenesis-associated multipass transmembrane protein 4."},{"id":"ENSMUSP00000004326","abundance":1.51,"rank":9463,"name":"Plxna3","annotation":"Plexin-A3; Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for s [...] "},{"id":"ENSMUSP00000066786","abundance":1.51,"rank":9464,"name":"Tex37","annotation":"Testis-expressed sequence 37 protein."},{"id":"ENSMUSP00000049336","abundance":1.51,"rank":9465,"name":"Spire1","annotation":"Protein spire homolog 1; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis ; Belongs to the spire family."},{"id":"ENSMUSP00000021495","abundance":1.51,"rank":9466,"name":"Serpina5","annotation":"Plasma serine protease inhibitor; Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coa [...] "},{"id":"ENSMUSP00000154314","abundance":1.51,"rank":9467,"name":"Vmn1r202","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000059039","abundance":1.51,"rank":9468,"name":"Ssbp4","annotation":"Single stranded DNA-binding protein 4."},{"id":"ENSMUSP00000102267","abundance":1.5,"rank":9469,"name":"Amigo1","annotation":"Amphoterin-induced protein 1; Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity). Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1."},{"id":"ENSMUSP00000027455","abundance":1.5,"rank":9470,"name":"Alppl2","annotation":"Alkaline phosphatase, germ cell type."},{"id":"ENSMUSP00000109203","abundance":1.5,"rank":9471,"name":"Atrx","annotation":"Transcriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] "},{"id":"ENSMUSP00000139342","abundance":1.5,"rank":9472,"name":"Calm5","annotation":"Skin calmodulin-related protein 2."},{"id":"ENSMUSP00000088803","abundance":1.5,"rank":9473,"name":"Slc7a14","annotation":"Probable cationic amino acid transporter; May be involved in arginine transport."},{"id":"ENSMUSP00000091620","abundance":1.5,"rank":9474,"name":"Kdm6b","annotation":"Lysine-specific demethylase 6B; Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expressio [...] "},{"id":"ENSMUSP00000132514","abundance":1.5,"rank":9475,"name":"Katna1","annotation":"Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of  [...] "},{"id":"ENSMUSP00000033180","abundance":1.5,"rank":9476,"name":"Vwa3a","annotation":"Von Willebrand factor A domain-containing protein 3A."},{"id":"ENSMUSP00000099913","abundance":1.5,"rank":9477,"name":"Usp20","annotation":"Ubiquitin carboxyl-terminal hydrolase 20; Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins de [...] "},{"id":"ENSMUSP00000142319","abundance":1.5,"rank":9478,"name":"Pcdh7","annotation":"Protocadherin 7."},{"id":"ENSMUSP00000028595","abundance":1.5,"rank":9479,"name":"Depdc7","annotation":"DEP domain-containing protein 7."},{"id":"ENSMUSP00000054637","abundance":1.5,"rank":9480,"name":"Il27","annotation":"Interleukin-27 subunit alpha; Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal ex [...] "},{"id":"ENSMUSP00000154540","abundance":1.5,"rank":9481,"name":"Vmn1r75","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000108715","abundance":1.5,"rank":9482,"name":"Rpusd3","annotation":"Mitochondrial mRNA pseudouridine synthase Rpusd3; Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs), a post- transcriptional modification necessary for their translation. Acts at position 390 in COXI mt-mRNA and at position 697-699 in mitochondrial COXIII mt-mRNA. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and may play a role in mitochondrial ribosome biogenesis."},{"id":"ENSMUSP00000105350","abundance":1.5,"rank":9483,"name":"Snta1","annotation":"Alpha-1-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the extracellular matrix via the dystrophin glycoprotein complex. Plays an important role in synapse formation and in the organization of UTRN and acetylcholine receptors at the neuromuscular synapse. Binds to phosphatidylinositol 4,5-bisphosphate."},{"id":"ENSMUSP00000130423","abundance":1.5,"rank":9484,"name":"Lingo2","annotation":"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2."},{"id":"ENSMUSP00000126352","abundance":1.5,"rank":9485,"name":"Chd2","annotation":"Chromodomain-helicase-DNA-binding protein 2; DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression."},{"id":"ENSMUSP00000068652","abundance":1.5,"rank":9486,"name":"Osbp2","annotation":"Oxysterol-binding protein 2; Binds 7-ketocholesterol; Belongs to the OSBP family."},{"id":"ENSMUSP00000150141","abundance":1.5,"rank":9487,"name":"Olfr623","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000126914","abundance":1.5,"rank":9488,"name":"Gpr35","annotation":"G-protein coupled receptor 35; Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins."},{"id":"ENSMUSP00000032874","abundance":1.5,"rank":9489,"name":"Sh3gl3","annotation":"Endophilin-A3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity); Belongs to the endophilin family."},{"id":"ENSMUSP00000098000","abundance":1.5,"rank":9490,"name":"Urad","annotation":"2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; Catalyzes the stereoselective decarboxylation of 2-oxo-4- hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin."},{"id":"ENSMUSP00000027931","abundance":1.5,"rank":9491,"name":"Nek2","annotation":"Serine/threonine-protein kinase Nek2; Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint  [...] "},{"id":"ENSMUSP00000116756","abundance":1.5,"rank":9492,"name":"Sypl2","annotation":"Synaptophysin-like protein 2; Involved in communication between the T-tubular and junctional sarcoplasmic reticulum (SR) membranes."},{"id":"ENSMUSP00000037113","abundance":1.5,"rank":9493,"name":"Cdh6","annotation":"Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."},{"id":"ENSMUSP00000087208","abundance":1.5,"rank":9494,"name":"Cep152","annotation":"Centrosomal protein of 152 kDa; Necessary for centrosome duplication; the function seems also to involve CEP63, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ, 2 molecules involved in centriole formation (By similarity). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (By similarity). Also pla [...] "},{"id":"ENSMUSP00000029545","abundance":1.5,"rank":9495,"name":"Crtc2","annotation":"CREB-regulated transcription coactivator 2; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated. Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitoch [...] "},{"id":"ENSMUSP00000097620","abundance":1.5,"rank":9496,"name":"Sp5","annotation":"Transcription factor Sp5; Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo."},{"id":"ENSMUSP00000062747","abundance":1.49,"rank":9497,"name":"Hnmt","annotation":"Histamine N-methyltransferase; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine."},{"id":"ENSMUSP00000077879","abundance":1.49,"rank":9498,"name":"Klk1b1","annotation":"Kallikrein 1-related peptidase b1; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000125253","abundance":1.49,"rank":9499,"name":"Zbtb37","annotation":"Zinc finger and BTB domain-containing 37."},{"id":"ENSMUSP00000032512","abundance":1.49,"rank":9500,"name":"Klrb1a","annotation":"Killer cell lectin-like receptor subfamily B member 1A; Plays a stimulatory role on natural killer (NK) cell cytotoxicity."},{"id":"ENSMUSP00000104335","abundance":1.49,"rank":9501,"name":"Myocd","annotation":"Myocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters."},{"id":"ENSMUSP00000034803","abundance":1.49,"rank":9502,"name":"Zw10","annotation":"Centromere/kinetochore protein zw10 homolog; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assemb [...] "},{"id":"ENSMUSP00000099889","abundance":1.49,"rank":9503,"name":"Ifit3","annotation":"Interferon-induced protein with tetratricopeptide repeats 3; IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B [...] "},{"id":"ENSMUSP00000136377","abundance":1.49,"rank":9504,"name":"Nim1k","annotation":"Serine/threonine-protein kinase NIM1; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family."},{"id":"ENSMUSP00000009705","abundance":1.49,"rank":9505,"name":"Eng","annotation":"Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a role in the binding of endothelial cells to integrins. Acts as TGF-beta corecep [...] "},{"id":"ENSMUSP00000129375","abundance":1.49,"rank":9506,"name":"Med16","annotation":"Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000058746","abundance":1.49,"rank":9507,"name":"Rabl6","annotation":"Rab-like protein 6; May enhance cellular proliferation. May reduce growth inhibitory activity of CDKN2A (By similarity); Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000001327","abundance":1.49,"rank":9508,"name":"Itgb7","annotation":"Integrin beta-7; Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is involved in adhesive interactions of leukocytes. It is a receptor for fibronectin and recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1 and VCAM1. It recognizes the sequence L-D-T in MADCAM1. Integrin alpha-E/beta-7 is a receptor for E- cadherin."},{"id":"ENSMUSP00000121249","abundance":1.49,"rank":9509,"name":"Uggt2","annotation":"UDP-glucose glycoprotein glucosyltransferase 2."},{"id":"ENSMUSP00000035027","abundance":1.49,"rank":9510,"name":"Clstn2","annotation":"Calsyntenin-2; May modulate calcium-mediated postsynaptic signals."},{"id":"ENSMUSP00000043329","abundance":1.49,"rank":9511,"name":"Msantd2","annotation":"Myb/SANT-like DNA-binding domain-containing protein 2."},{"id":"ENSMUSP00000022618","abundance":1.49,"rank":9512,"name":"Adam2","annotation":"Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity)."},{"id":"ENSMUSP00000146552","abundance":1.49,"rank":9513,"name":"Olfr1424","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000108863","abundance":1.49,"rank":9514,"name":"Trem2","annotation":"Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro- inflammatory cytokines, such as IL6R and CCL3, and the anti- inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as  [...] "},{"id":"ENSMUSP00000048568","abundance":1.49,"rank":9515,"name":"Mgl2","annotation":"Macrophage galactose N-acetyl-galactosamine-specific lectin 2."},{"id":"ENSMUSP00000003284","abundance":1.49,"rank":9516,"name":"Irf3","annotation":"Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN- beta) and IFN-stimulated genes (ISG) by binding to an interferon- stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inacti [...] "},{"id":"ENSMUSP00000025472","abundance":1.49,"rank":9517,"name":"Pcyox1l","annotation":"Prenylcysteine oxidase-like; Probable oxidoreductase."},{"id":"ENSMUSP00000067614","abundance":1.48,"rank":9518,"name":"Ptpn4","annotation":"Tyrosine-protein phosphatase non-receptor type 4; Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis. Regulates neuronal cell homeostasis by protecting neurons against apoptosis (By similarity). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction. Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway. May act at junctions between the membran [...] "},{"id":"ENSMUSP00000008052","abundance":1.48,"rank":9519,"name":"Hmgcll1","annotation":"3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic; Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3- methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues."},{"id":"ENSMUSP00000126108","abundance":1.48,"rank":9520,"name":"Acvr2b","annotation":"Activin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to  [...] "},{"id":"ENSMUSP00000073972","abundance":1.48,"rank":9521,"name":"Slc35f4","annotation":"Solute carrier family 35 member F4; Putative solute transporter."},{"id":"ENSMUSP00000079265","abundance":1.48,"rank":9522,"name":"Magel2","annotation":"MAGE-like protein 2; Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly (By similarity). Regulates the circadian clock by repressing the trans [...] "},{"id":"ENSMUSP00000021828","abundance":1.48,"rank":9523,"name":"Nxnl2","annotation":"Nucleoredoxin-like protein 2; May be involved in the maintenance of both the function and the viability of sensory neurons, including photoreceptors and olfactory neurons. In the retina, isoform 1 may be required for rod function and isoform 2 for cone viability and function. Belongs to the nucleoredoxin family."},{"id":"ENSMUSP00000063913","abundance":1.48,"rank":9524,"name":"Fam204a","annotation":"Protein FAM204A."},{"id":"ENSMUSP00000015611","abundance":1.48,"rank":9525,"name":"Egfl8","annotation":"Epidermal growth factor-like protein 8."},{"id":"ENSMUSP00000041727","abundance":1.48,"rank":9526,"name":"Zdhhc2","annotation":"Palmitoyltransferase ZDHHC2; Palmitoyltransferase specific for GAP43 and DLG4/PSD95."},{"id":"ENSMUSP00000035110","abundance":1.48,"rank":9527,"name":"Hhatl","annotation":"Protein-cysteine N-palmitoyltransferase HHAT-like protein; Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN."},{"id":"ENSMUSP00000066803","abundance":1.48,"rank":9528,"name":"2310022A10Rik","annotation":"Uncharacterized protein C19orf47 homolog."},{"id":"ENSMUSP00000049020","abundance":1.48,"rank":9529,"name":"Mslnl","annotation":"Mesothelin-like protein; May play a role in cellular adhesion; Belongs to the mesothelin family."},{"id":"ENSMUSP00000029194","abundance":1.48,"rank":9530,"name":"Skil","annotation":"Ski-like protein; May have regulatory role in cell division or differentiation in response to extracellular signals; Belongs to the SKI family."},{"id":"ENSMUSP00000049175","abundance":1.48,"rank":9531,"name":"Gna15","annotation":"Guanine nucleotide-binding protein subunit alpha-15; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems."},{"id":"ENSMUSP00000023524","abundance":1.48,"rank":9532,"name":"Rabl3","annotation":"Rab-like protein 3."},{"id":"ENSMUSP00000028821","abundance":1.48,"rank":9533,"name":"Fsip1","annotation":"Fibrous sheath-interacting protein 1; Belongs to the FSIP1 family."},{"id":"ENSMUSP00000124052","abundance":1.48,"rank":9534,"name":"Reln","annotation":"Reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation; Belongs to the reelin family."},{"id":"ENSMUSP00000022368","abundance":1.48,"rank":9535,"name":"Plau","annotation":"Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000015605","abundance":1.48,"rank":9536,"name":"Atf6b","annotation":"Processed cyclic AMP-dependent transcription factor ATF-6 beta; Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (By similarity); Belongs to the bZIP family. ATF subfamily."},{"id":"ENSMUSP00000002848","abundance":1.48,"rank":9537,"name":"Grin2d","annotation":"Glutamate receptor ionotropic, NMDA 2D; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable); Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D sub [...] "},{"id":"ENSMUSP00000055656","abundance":1.48,"rank":9538,"name":"6030458C11Rik","annotation":"UPF0489 protein C5orf22 homolog."},{"id":"ENSMUSP00000093130","abundance":1.48,"rank":9539,"name":"Lig4","annotation":"DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends."},{"id":"ENSMUSP00000127751","abundance":1.48,"rank":9540,"name":"Endod1","annotation":"Endonuclease domain-containing 1 protein; May act as a DNase and a RNase; Belongs to the DNA/RNA non-specific endonuclease family."},{"id":"ENSMUSP00000005954","abundance":1.48,"rank":9541,"name":"Bloc1s6","annotation":"Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] "},{"id":"ENSMUSP00000077833","abundance":1.48,"rank":9542,"name":"Lilrb4a","annotation":"Leukocyte immunoglobulin-like receptor subfamily B member 4; Receptor for class I MHC antigens. Involved in the down- regulation of the immune response and the development of tolerance. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (By similarity)."},{"id":"ENSMUSP00000151486","abundance":1.48,"rank":9543,"name":"Gm49339","annotation":"Predicted gene, 49339."},{"id":"ENSMUSP00000041744","abundance":1.48,"rank":9544,"name":"Ofd1","annotation":"Oral-facial-digital syndrome 1 protein homolog; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the  [...] "},{"id":"ENSMUSP00000064443","abundance":1.48,"rank":9545,"name":"Slitrk4","annotation":"SLIT and NTRK-like protein 4; It is involved in synaptogenesis and promotes synapse differentiation (By similarity). Suppresses neurite outgrowth."},{"id":"ENSMUSP00000040802","abundance":1.48,"rank":9546,"name":"Haus8","annotation":"HAUS augmin-like complex subunit 8; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex; Belongs to the HAUS8 family."},{"id":"ENSMUSP00000021130","abundance":1.48,"rank":9547,"name":"Ten1","annotation":"CST complex subunit TEN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] "},{"id":"ENSMUSP00000062758","abundance":1.48,"rank":9548,"name":"Bmerb1","annotation":"bMERB domain-containing protein 1."},{"id":"ENSMUSP00000098099","abundance":1.47,"rank":9549,"name":"Gal3st4","annotation":"Galactose-3-O-sulfotransferase 4."},{"id":"ENSMUSP00000142200","abundance":1.47,"rank":9550,"name":"Nlgn1","annotation":"Neuroligin-1; Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Required to maintain wakefulness quality and normal synchrony of cerebral cortex activity during wakefulness and  [...] "},{"id":"ENSMUSP00000104747","abundance":1.47,"rank":9551,"name":"Zfp354a","annotation":"Zinc finger protein 354A; It may play a role in renal development and may also be involved in the repair of the kidney after ischemia-reperfusion or folic acid administration."},{"id":"ENSMUSP00000041904","abundance":1.47,"rank":9552,"name":"C130074G19Rik","annotation":"Uncharacterized protein C1orf115 homolog."},{"id":"ENSMUSP00000056457","abundance":1.47,"rank":9553,"name":"Olfr324","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000088563","abundance":1.47,"rank":9554,"name":"Ralgps1","annotation":"Ras-specific guanine nucleotide-releasing factor RalGPS1; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeleton organization."},{"id":"ENSMUSP00000101830","abundance":1.47,"rank":9555,"name":"Ndufaf8","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8; Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1). Required to stabilize NDUFAF5."},{"id":"ENSMUSP00000021240","abundance":1.47,"rank":9556,"name":"Cdc34b","annotation":"Cell division cycle 34B; Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000092637","abundance":1.47,"rank":9557,"name":"Aff3","annotation":"AF4/FMR2 family member 3; Putative transcription activator that may function in lymphoid development and oncogenesis."},{"id":"ENSMUSP00000043437","abundance":1.47,"rank":9558,"name":"Ric1","annotation":"RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1."},{"id":"ENSMUSP00000043874","abundance":1.47,"rank":9559,"name":"Kmt2c","annotation":"Histone-lysine N-methyltransferase 2C; Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex (By similarity)."},{"id":"ENSMUSP00000048519","abundance":1.47,"rank":9560,"name":"Degs1","annotation":"Sphingolipid delta(4)-desaturase DES1; Has sphingolipid-delta-4-desaturase activity. Converts D- erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine)."},{"id":"ENSMUSP00000031695","abundance":1.47,"rank":9561,"name":"Wasl","annotation":"Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] "},{"id":"ENSMUSP00000031894","abundance":1.47,"rank":9562,"name":"Clcn1","annotation":"Chloride channel protein 1; Voltage-gated chloride channel (By similarity). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction (Probable)."},{"id":"ENSMUSP00000029971","abundance":1.47,"rank":9563,"name":"Cfap206","annotation":"Cilia- and flagella-associated protein 206; May regulate cilium motility through its role in the assembly of the axonemal radial spokes."},{"id":"ENSMUSP00000032728","abundance":1.47,"rank":9564,"name":"Tarsl2","annotation":"Threonine--tRNA ligase 2, cytoplasmic; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post- transfer stage."},{"id":"ENSMUSP00000043554","abundance":1.47,"rank":9565,"name":"Dok4","annotation":"Docking protein 4; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells (By similarity)."},{"id":"ENSMUSP00000150315","abundance":1.47,"rank":9566,"name":"Olfr1361","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000136885","abundance":1.47,"rank":9567,"name":"LOC671917","annotation":"Component of Sp100-rs-like."},{"id":"ENSMUSP00000137243","abundance":1.47,"rank":9568,"name":"LOC102636558","annotation":"Component of Sp100-rs-like."},{"id":"ENSMUSP00000078372","abundance":1.47,"rank":9569,"name":"Pgghg","annotation":"Protein-glucosylgalactosylhydroxylysine glucosidase; Catalyzes the hydrolysis of glucose from the disaccharide unit linked to hydroxylysine residues of collagen and collagen-like proteins."},{"id":"ENSMUSP00000003655","abundance":1.47,"rank":9570,"name":"As3mt","annotation":"Arsenite methyltransferase; Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Belongs to the methyltransferase superfamily. Arsenite methyltransferase family."},{"id":"ENSMUSP00000084541","abundance":1.47,"rank":9571,"name":"Foxd3","annotation":"Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis."},{"id":"ENSMUSP00000049056","abundance":1.47,"rank":9572,"name":"Nek9","annotation":"Serine/threonine-protein kinase Nek9; Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr- 97 respectively (By similarity); Belongs to the protein kinase superfamily. NEK S [...] "},{"id":"ENSMUSP00000146782","abundance":1.47,"rank":9573,"name":"Olfr1480","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000099385","abundance":1.46,"rank":9574,"name":"Wfdc3","annotation":"WAP four-disulfide core domain protein 3."},{"id":"ENSMUSP00000156253","abundance":1.46,"rank":9575,"name":"Zdhhc23","annotation":"Palmitoyltransferase ZDHHC23; Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane (By similarity)."},{"id":"ENSMUSP00000050123","abundance":1.46,"rank":9576,"name":"Pnpla1","annotation":"Patatin-like phospholipase domain-containing protein 1; Lipid hydrolase."},{"id":"ENSMUSP00000083193","abundance":1.46,"rank":9577,"name":"Caln1","annotation":"Calcium-binding protein 8; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning."},{"id":"ENSMUSP00000048742","abundance":1.46,"rank":9578,"name":"Bsdc1","annotation":"BSD domain-containing protein 1."},{"id":"ENSMUSP00000150496","abundance":1.46,"rank":9579,"name":"Olfr980","annotation":"Olfactory receptor MOR223-2."},{"id":"ENSMUSP00000067691","abundance":1.46,"rank":9580,"name":"Obox1","annotation":"Oocyte-specific homeobox 1."},{"id":"ENSMUSP00000149370","abundance":1.46,"rank":9581,"name":"Olfr1506","annotation":"Olfactory receptor 1506."},{"id":"ENSMUSP00000148849","abundance":1.46,"rank":9582,"name":"Olfr1274","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000148860","abundance":1.46,"rank":9583,"name":"Olfr1565","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000153206","abundance":1.46,"rank":9584,"name":"Pcgf5","annotation":"Polycomb group RING finger protein 5; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF3 as part of a PRC1-like complex th [...] "},{"id":"ENSMUSP00000049997","abundance":1.46,"rank":9585,"name":"Mettl24","annotation":"Methyltransferase-like protein 24."},{"id":"ENSMUSP00000050554","abundance":1.46,"rank":9586,"name":"Ccer1","annotation":"Coiled-coil domain-containing glutamate-rich protein 1."},{"id":"ENSMUSP00000129125","abundance":1.46,"rank":9587,"name":"Zfp454","annotation":"Zinc finger protein 454."},{"id":"ENSMUSP00000113708","abundance":1.46,"rank":9588,"name":"Xkr6","annotation":"XK-related protein 6; Belongs to the XK family."},{"id":"ENSMUSP00000033950","abundance":1.46,"rank":9589,"name":"Gins4","annotation":"DNA replication complex GINS protein SLD5, N-terminally processed; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS4 is important for GINS complex assembly. GINS complex seems to bind preferentially to single-stranded DNA (By similarity); Belongs to the GINS4/SLD5 family."},{"id":"ENSMUSP00000103566","abundance":1.46,"rank":9590,"name":"1700008O03Rik","annotation":"Putative uncharacterized protein C19orf81 homolog."},{"id":"ENSMUSP00000057905","abundance":1.46,"rank":9591,"name":"Mgat2","annotation":"Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. Belongs to the glycosyltransferase 16 (GT16) protein family."},{"id":"ENSMUSP00000054462","abundance":1.46,"rank":9592,"name":"Pqlc3","annotation":"Solute carrier family 66 member 3."},{"id":"ENSMUSP00000048971","abundance":1.46,"rank":9593,"name":"Sirt6","annotation":"NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. On DNA damage, promotes DNA end res [...] "},{"id":"ENSMUSP00000086730","abundance":1.46,"rank":9594,"name":"Magi1","annotation":"Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1; May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface."},{"id":"ENSMUSP00000118743","abundance":1.46,"rank":9595,"name":"Sfxn4","annotation":"Sideroflexin-4; Mitochondrial amino-acid transporter (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity)."},{"id":"ENSMUSP00000028950","abundance":1.46,"rank":9596,"name":"Sdcbp2","annotation":"Syntenin-2; Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival."},{"id":"ENSMUSP00000030585","abundance":1.46,"rank":9597,"name":"A3galt2","annotation":"Alpha-1,3-galactosyltransferase 2; Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures. Synthesis of iGb3 is the initial step in the formation of the isoglobo- series glycolipid pathway and is the precursor to isogloboside 4 (iGb4) and isoForssman glycolipids. Can glycosylate only lipids and not proteins and i [...] "},{"id":"ENSMUSP00000016143","abundance":1.46,"rank":9598,"name":"Wasf3","annotation":"Wiskott-Aldrich syndrome protein family member 3; Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity)."},{"id":"ENSMUSP00000080556","abundance":1.45,"rank":9599,"name":"Lamp3","annotation":"Lysosome-associated membrane glycoprotein 3; May play a role in dendritic cell function and in adaptive immunity."},{"id":"ENSMUSP00000082183","abundance":1.45,"rank":9600,"name":"Cish","annotation":"Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...] "},{"id":"ENSMUSP00000027271","abundance":1.45,"rank":9601,"name":"Inpp1","annotation":"Inositol polyphosphate 1-phosphatase."},{"id":"ENSMUSP00000095331","abundance":1.45,"rank":9602,"name":"Fam126b","annotation":"Protein FAM126B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane."},{"id":"ENSMUSP00000120276","abundance":1.45,"rank":9603,"name":"Hoxa10","annotation":"Homeobox protein Hox-A10; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to the DNA sequence 5'-AA[AT]TTTTATTAC-3'; Belongs to the Abd-B homeobox family."},{"id":"ENSMUSP00000111186","abundance":1.45,"rank":9604,"name":"Mid1ip1","annotation":"Mid1-interacting protein 1; Plays a role in the regulation of lipogenesis in liver. Up- regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules. Belongs to the SPOT14 family."},{"id":"ENSMUSP00000101968","abundance":1.45,"rank":9605,"name":"Olfr1330","annotation":"Olfactory receptor MOR259-8."},{"id":"ENSMUSP00000098127","abundance":1.45,"rank":9606,"name":"Cacna1g","annotation":"Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the \"low-voltage activated (LVA)\" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] "},{"id":"ENSMUSP00000065456","abundance":1.45,"rank":9607,"name":"Rab7b","annotation":"Ras-related protein Rab-7b; Controls vesicular trafficking from endosomes to the trans- Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation [...] "},{"id":"ENSMUSP00000020149","abundance":1.45,"rank":9608,"name":"Ikbip","annotation":"Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function."},{"id":"ENSMUSP00000020215","abundance":1.45,"rank":9609,"name":"Socs2","annotation":"Suppressor of cytokine signaling 2; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity)."},{"id":"ENSMUSP00000130759","abundance":1.45,"rank":9610,"name":"Traf1","annotation":"TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin- protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity)."},{"id":"ENSMUSP00000098200","abundance":1.45,"rank":9611,"name":"Lratd2","annotation":"LRAT domain-containing 1."},{"id":"ENSMUSP00000068932","abundance":1.45,"rank":9612,"name":"D630039A03Rik","annotation":"RIKEN cDNA D630039A03 gene."},{"id":"ENSMUSP00000024596","abundance":1.45,"rank":9613,"name":"Slc22a1","annotation":"Solute carrier family 22 member 1; Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1- methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1- methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N- methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA recepto [...] "},{"id":"ENSMUSP00000122852","abundance":1.45,"rank":9614,"name":"Myo9a","annotation":"Unconventional myosin-IXa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons. Required for the regulation of neurite branching and motor neuron axon guidance."},{"id":"ENSMUSP00000023357","abundance":1.45,"rank":9615,"name":"Fopnl","annotation":"LisH domain-containing protein FOPNL; Involved in the biogenesis of cilia (By similarity). Required for the recruitment of PLK1 to centrosomes and S phase progression (By similarity)."},{"id":"ENSMUSP00000085497","abundance":1.45,"rank":9616,"name":"Hs6st2","annotation":"Heparan-sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate."},{"id":"ENSMUSP00000018549","abundance":1.45,"rank":9617,"name":"Mrm1","annotation":"rRNA methyltransferase 1, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA."},{"id":"ENSMUSP00000102538","abundance":1.45,"rank":9618,"name":"Ngf","annotation":"Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast [...] "},{"id":"ENSMUSP00000090602","abundance":1.45,"rank":9619,"name":"Spata22","annotation":"Spermatogenesis-associated protein 22; Meiosis-specific protein required for homologous recombination in meiosis I."},{"id":"ENSMUSP00000027032","abundance":1.45,"rank":9620,"name":"Rp1","annotation":"Oxygen-regulated protein 1; Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher-order stacking of outer segment disks along the photoreceptor axoneme."},{"id":"ENSMUSP00000066789","abundance":1.44,"rank":9621,"name":"Ep300","annotation":"Histone acetyltransferase p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (By similarity). Acetylates all four core histones in nucleosomes (By similarity). Histone acetylation gives an epigenetic tag for transcriptional activation (By similarity). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability (By  [...] "},{"id":"ENSMUSP00000151908","abundance":1.44,"rank":9622,"name":"Olfr450","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000029842","abundance":1.44,"rank":9623,"name":"Bcl10","annotation":"B-cell lymphoma/leukemia 10; Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1."},{"id":"ENSMUSP00000006969","abundance":1.44,"rank":9624,"name":"Krt23","annotation":"Keratin, type I cytoskeletal 23; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000130967","abundance":1.44,"rank":9625,"name":"Prepl","annotation":"Prolyl endopeptidase-like; Serine peptidase whose precise substrate specificity remains unclear. Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex. May play a role in the regulation of synaptic vesicle exocytosis (By similarity)."},{"id":"ENSMUSP00000051414","abundance":1.44,"rank":9626,"name":"Tmem17","annotation":"Transmembrane protein 17; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling."},{"id":"ENSMUSP00000037340","abundance":1.44,"rank":9627,"name":"Wdr70","annotation":"WD repeat-containing protein 70; Belongs to the WD repeat GAD-1 family."},{"id":"ENSMUSP00000076472","abundance":1.44,"rank":9628,"name":"Dhrsx","annotation":"Dehydrogenase/reductase SDR family member on chromosome X homolog; Involved in the positive regulation of starvation-induced autophagy."},{"id":"ENSMUSP00000040060","abundance":1.44,"rank":9629,"name":"Slfn8","annotation":"Schlafen family member 8; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. May be involved in immune system via regulation of inflammation."},{"id":"ENSMUSP00000131288","abundance":1.44,"rank":9630,"name":"Trim30b","annotation":"Tripartite motif-containing 30B."},{"id":"ENSMUSP00000151198","abundance":1.44,"rank":9631,"name":"Zfp445","annotation":"Zinc finger protein 445; Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZFP57, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, ZNF445 seems to be the major factor in human early embryonic imprintin [...] "},{"id":"ENSMUSP00000045413","abundance":1.44,"rank":9632,"name":"Tbc1d2b","annotation":"TBC1 domain family member 2B; May act as a GTPase-activating protein."},{"id":"ENSMUSP00000031640","abundance":1.44,"rank":9633,"name":"Cdk8","annotation":"Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) of the l [...] "},{"id":"ENSMUSP00000127396","abundance":1.44,"rank":9634,"name":"Sox21","annotation":"Transcription factor SOX-21; May play a role as an activator of transcription of OPRM1. Overexpression of SOX21 can up-regulate the OPRM1 distal promoter activity in mor-expressing neuronal cells."},{"id":"ENSMUSP00000125149","abundance":1.44,"rank":9635,"name":"Lypd1","annotation":"Ly6/PLAUR domain-containing protein 1; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2- containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety."},{"id":"ENSMUSP00000037884","abundance":1.44,"rank":9636,"name":"Tbc1d12","annotation":"TBC1 domain family member 12; RAB11A-binding protein that plays a role in neurite outgrowth."},{"id":"ENSMUSP00000140836","abundance":1.44,"rank":9637,"name":"Prmt6","annotation":"Protein arginine N-methyltransferase 6; Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (By similarity). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (By similarity). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutuall [...] "},{"id":"ENSMUSP00000133939","abundance":1.44,"rank":9638,"name":"Otud4","annotation":"OTU domain-containing protein 4; Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'- polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic a [...] "},{"id":"ENSMUSP00000045043","abundance":1.44,"rank":9639,"name":"Dnttip2","annotation":"Deoxynucleotidyltransferase terminal-interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein (By similarity)."},{"id":"ENSMUSP00000133356","abundance":1.44,"rank":9640,"name":"Hap1","annotation":"Huntingtin-associated protein 1; Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via associati [...] "},{"id":"ENSMUSP00000104890","abundance":1.44,"rank":9641,"name":"Map3k1","annotation":"Mitogen-activated protein kinase kinase kinase 1; Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway."},{"id":"ENSMUSP00000109398","abundance":1.44,"rank":9642,"name":"Arr3","annotation":"Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins."},{"id":"ENSMUSP00000107733","abundance":1.44,"rank":9643,"name":"Mid1","annotation":"E3 ubiquitin-protein ligase Midline-1; Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination."},{"id":"ENSMUSP00000099494","abundance":1.44,"rank":9644,"name":"Polr1b","annotation":"DNA-directed RNA polymerase I subunit RPA2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity)."},{"id":"ENSMUSP00000034190","abundance":1.44,"rank":9645,"name":"Vac14","annotation":"Protein VAC14 homolog; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts as a positive activator of PIKfyve kinase activity. Also required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P). Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes."},{"id":"ENSMUSP00000104093","abundance":1.44,"rank":9646,"name":"Zfp296","annotation":"Zinc finger protein 296; May be a transcriptional corepressor with KLF4."},{"id":"ENSMUSP00000095965","abundance":1.44,"rank":9647,"name":"Mbtps1","annotation":"Membrane-bound transcription factor site-1 protease; Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysos [...] "},{"id":"ENSMUSP00000085499","abundance":1.44,"rank":9648,"name":"Hs6st1","annotation":"Heparan-sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development. May prefer iduronic acid."},{"id":"ENSMUSP00000154125","abundance":1.44,"rank":9649,"name":"Rnase6","annotation":"Ribonuclease K6; Ribonuclease which shows a preference for the pyrimidines uridine and cytosine. Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli. Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility. Bactericidal activity is independent of RNase activity (By similarity)."},{"id":"ENSMUSP00000031017","abundance":1.43,"rank":9650,"name":"Fosl2","annotation":"Fos-related antigen 2; Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2- activated osteoblasts (By similarity)."},{"id":"ENSMUSP00000098312","abundance":1.43,"rank":9651,"name":"Hvcn1","annotation":"Voltage-gated hydrogen channel 1; Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis."},{"id":"ENSMUSP00000107804","abundance":1.43,"rank":9652,"name":"Mettl8","annotation":"mRNA N(3)-methylcytidine methyltransferase METTL8; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of mRNAs.  [Isoform 4]: Stimulates adipogenesis. Belongs to the methyltransferase superfamily. METL family."},{"id":"ENSMUSP00000040757","abundance":1.43,"rank":9653,"name":"Tent4a","annotation":"Terminal nucleotidyltransferase 4A; Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (By similarity). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post- transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA sub [...] "},{"id":"ENSMUSP00000054033","abundance":1.43,"rank":9654,"name":"Gcc2","annotation":"GRIP and coiled-coil domain-containing protein 2; Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi- associated microtubules through recruitment of CLASP1 and CLASP2 (By similarity)."},{"id":"ENSMUSP00000149743","abundance":1.43,"rank":9655,"name":"Olfr639","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000071615","abundance":1.43,"rank":9656,"name":"Tas2r123","annotation":"Taste receptor type 2 member 123; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)."},{"id":"ENSMUSP00000043325","abundance":1.43,"rank":9657,"name":"Scgb3a1","annotation":"Secretoglobin family 3A member 1; Secreted cytokine-like protein. Inhibits cell growth in vitro."},{"id":"ENSMUSP00000132812","abundance":1.43,"rank":9658,"name":"Dlc1","annotation":"Rho GTPase-activating protein 7; Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity)."},{"id":"ENSMUSP00000015987","abundance":1.43,"rank":9659,"name":"Rxrg","annotation":"Retinoic acid receptor RXR-gamma; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)."},{"id":"ENSMUSP00000077459","abundance":1.43,"rank":9660,"name":"Csgalnact1","annotation":"Chondroitin sulfate N-acetylgalactosaminyltransferase 1; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation, and subsequent endochondral ossification. Moreover, is involved in the metabolism of aggrecan."},{"id":"ENSMUSP00000101373","abundance":1.43,"rank":9661,"name":"Aadacl4fm4","annotation":"AADACL4 family member 4."},{"id":"ENSMUSP00000054263","abundance":1.43,"rank":9662,"name":"Hjurp","annotation":"Holliday junction recognition protein; Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions."},{"id":"ENSMUSP00000047327","abundance":1.43,"rank":9663,"name":"Plekhm1","annotation":"Pleckstrin homology domain-containing family M member 1; Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion. Positively regulates lysosome peripheral distributi [...] "},{"id":"ENSMUSP00000041373","abundance":1.43,"rank":9664,"name":"Neurod2","annotation":"Neurogenic differentiation factor 2; Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down- regulating REST expression. Plays a role in the establishment and maturation of thalamocor [...] "},{"id":"ENSMUSP00000125840","abundance":1.43,"rank":9665,"name":"Eps8l1","annotation":"Epidermal growth factor receptor kinase substrate 8-like protein 1; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity); Belongs to the EPS8 family."},{"id":"ENSMUSP00000027906","abundance":1.43,"rank":9666,"name":"Esrrg","annotation":"Estrogen-related receptor gamma; Orphan receptor that acts as transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements. Induces the expression of PERM1 in the skeletal muscle."},{"id":"ENSMUSP00000053146","abundance":1.43,"rank":9667,"name":"Phf11a","annotation":"PHD finger protein 11A."},{"id":"ENSMUSP00000031325","abundance":1.43,"rank":9668,"name":"Areg","annotation":"Amphiregulin; Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts; Belongs to the amphiregulin family."},{"id":"ENSMUSP00000157839","abundance":1.43,"rank":9669,"name":"Kif20a","annotation":"Kinesin-like protein KIF20A; Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle (By similarity). Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family."},{"id":"ENSMUSP00000025198","abundance":1.43,"rank":9670,"name":"Btnl2","annotation":"Butyrophilin-like protein 2; Negative regulator of T-cell proliferation. Belongs to the immunoglobulin superfamily. BTN/MOG family."},{"id":"ENSMUSP00000099806","abundance":1.43,"rank":9671,"name":"Tnfaip2","annotation":"Tumor necrosis factor alpha-induced protein 2; May play a role as a mediator of inflammation and angiogenesis; Belongs to the SEC6 family."},{"id":"ENSMUSP00000024766","abundance":1.43,"rank":9672,"name":"Rrp36","annotation":"Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA; Belongs to the RRP36 family."},{"id":"ENSMUSP00000060591","abundance":1.42,"rank":9673,"name":"Gpr119","annotation":"Glucose-dependent insulinotropic receptor; Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000137650","abundance":1.42,"rank":9674,"name":"Ascl4","annotation":"Achaete-scute family bHLH transcription factor 4."},{"id":"ENSMUSP00000139610","abundance":1.42,"rank":9675,"name":"Phf3","annotation":"PHD finger protein 3."},{"id":"ENSMUSP00000154640","abundance":1.42,"rank":9676,"name":"Gprin2","annotation":"G protein-regulated inducer of neurite outgrowth 2."},{"id":"ENSMUSP00000119369","abundance":1.42,"rank":9677,"name":"Becn1","annotation":"Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K comp [...] "},{"id":"ENSMUSP00000028068","abundance":1.42,"rank":9678,"name":"Ptf1a","annotation":"Pancreas transcription factor 1 subunit alpha; Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an impor [...] "},{"id":"ENSMUSP00000148966","abundance":1.42,"rank":9679,"name":"Ackr2","annotation":"Atypical chemokine receptor 2; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/M [...] "},{"id":"ENSMUSP00000019862","abundance":1.42,"rank":9680,"name":"L3hypdh","annotation":"Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C)."},{"id":"ENSMUSP00000093771","abundance":1.42,"rank":9681,"name":"Cpa2","annotation":"Carboxypeptidase A2."},{"id":"ENSMUSP00000066864","abundance":1.42,"rank":9682,"name":"Cdh22","annotation":"Cadherin-22; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues."},{"id":"ENSMUSP00000078536","abundance":1.42,"rank":9683,"name":"Vmn1r32","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000034094","abundance":1.42,"rank":9684,"name":"Gins3","annotation":"DNA replication complex GINS protein PSF3; The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA (By similarity)."},{"id":"ENSMUSP00000119729","abundance":1.42,"rank":9685,"name":"Sox13","annotation":"Transcription factor SOX-13; Binds to the sequence 5'-AACAAT-3'."},{"id":"ENSMUSP00000113307","abundance":1.42,"rank":9686,"name":"Tbc1d10b","annotation":"TBC1 domain family member 10B; Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A (By similarity)."},{"id":"ENSMUSP00000029635","abundance":1.42,"rank":9687,"name":"Gucy1b1","annotation":"Guanylate cyclase soluble subunit beta-1; Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP."},{"id":"ENSMUSP00000060622","abundance":1.42,"rank":9688,"name":"Aqp12","annotation":"Aquaporin-12; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily."},{"id":"ENSMUSP00000129116","abundance":1.42,"rank":9689,"name":"Sis","annotation":"Sucrase isomaltase (alpha-glucosidase)."},{"id":"ENSMUSP00000105191","abundance":1.42,"rank":9690,"name":"Ehbp1","annotation":"EH domain-binding protein 1; May play a role in actin reorganization. Links clathrin- mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes."},{"id":"ENSMUSP00000104471","abundance":1.42,"rank":9691,"name":"Cnot8","annotation":"CCR4-NOT transcription complex subunit 8; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a [...] "},{"id":"ENSMUSP00000049124","abundance":1.42,"rank":9692,"name":"Acbd6","annotation":"Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids (By similarity)."},{"id":"ENSMUSP00000155574","abundance":1.42,"rank":9693,"name":"Sox10","annotation":"Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity)."},{"id":"ENSMUSP00000156255","abundance":1.42,"rank":9694,"name":"Gm49711","annotation":"Predicted gene, 49711."},{"id":"ENSMUSP00000087371","abundance":1.42,"rank":9695,"name":"Dgkg","annotation":"Diacylglycerol kinase gamma."},{"id":"ENSMUSP00000022890","abundance":1.42,"rank":9696,"name":"Rnf19a","annotation":"E3 ubiquitin-protein ligase RNF19A; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR; Belongs to the RBR family. RNF19 subfamily."},{"id":"ENSMUSP00000130504","abundance":1.42,"rank":9697,"name":"Tmem255b","annotation":"Transmembrane protein 255B."},{"id":"ENSMUSP00000058599","abundance":1.42,"rank":9698,"name":"Tmem199","annotation":"Transmembrane protein 199; Accessory component of the proton-transporting vacuolar (V)- ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation (By similarity). May be involved in Golgi homeostasis (By similarity)."},{"id":"ENSMUSP00000103716","abundance":1.42,"rank":9699,"name":"Ggnbp2","annotation":"Gametogenetin-binding protein 2; May be involved in spermatogenesis."},{"id":"ENSMUSP00000068834","abundance":1.41,"rank":9700,"name":"Trib1","annotation":"Tribbles homolog 1; Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. Promotes CEBPA degradation and inhibits its function. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily."},{"id":"ENSMUSP00000078723","abundance":1.41,"rank":9701,"name":"Pth","annotation":"Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family."},{"id":"ENSMUSP00000153871","abundance":1.41,"rank":9702,"name":"Col20a1","annotation":"Collagen alpha-1(XX) chain; Probable collagen protein."},{"id":"ENSMUSP00000084411","abundance":1.41,"rank":9703,"name":"H2-M9","annotation":"Histocompatibility 2, M region locus 9; Belongs to the MHC class I family."},{"id":"ENSMUSP00000023426","abundance":1.41,"rank":9704,"name":"Cldnd1","annotation":"Claudin domain-containing protein 1."},{"id":"ENSMUSP00000069699","abundance":1.41,"rank":9705,"name":"Cndp1","annotation":"Beta-Ala-His dipeptidase; Belongs to the peptidase M20A family."},{"id":"ENSMUSP00000028369","abundance":1.41,"rank":9706,"name":"Dapl1","annotation":"Death-associated protein-like 1; May play a role in the early stages of epithelial differentiation or in apoptosis."},{"id":"ENSMUSP00000022705","abundance":1.41,"rank":9707,"name":"Med4","annotation":"Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000052303","abundance":1.41,"rank":9708,"name":"Bptf","annotation":"Bromodomain PHD finger transcription factor."},{"id":"ENSMUSP00000087686","abundance":1.41,"rank":9709,"name":"Bmf","annotation":"Bcl-2-modifying factor; May play a role in apoptosis; Belongs to the Bcl-2 family."},{"id":"ENSMUSP00000063719","abundance":1.41,"rank":9710,"name":"Fut2","annotation":"Galactoside 2-alpha-L-fucosyltransferase 2; Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids. The resulting epitope plays a role in cell-cell interaction including host-microbe interaction. Mediates interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen, which is an essential substrate for the final step in the blood group antigen synthesis pathway."},{"id":"ENSMUSP00000046905","abundance":1.41,"rank":9711,"name":"Leo1","annotation":"RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox  [...] "},{"id":"ENSMUSP00000068487","abundance":1.41,"rank":9712,"name":"Tgoln1","annotation":"Trans-Golgi network integral membrane protein 1; May be involved in regulating membrane traffic to and from trans-Golgi network."},{"id":"ENSMUSP00000065825","abundance":1.41,"rank":9713,"name":"Rgs17","annotation":"Regulator of G-protein signaling 17; Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins."},{"id":"ENSMUSP00000103922","abundance":1.41,"rank":9714,"name":"Sarm1","annotation":"NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism. Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site. Wallerian degeneration is triggered by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADPR (cADPR) and nicotinamide; NAD(+ [...] "},{"id":"ENSMUSP00000022945","abundance":1.41,"rank":9715,"name":"Shcbp1","annotation":"SHC SH2 domain-binding protein 1; May play a role in signaling pathways governing cellular proliferation, cell growth and differentiation. May be a component of a novel signaling pathway downstream of Shc. Acts as a positive regulator of FGF signaling in neural progenitor cells."},{"id":"ENSMUSP00000114578","abundance":1.41,"rank":9716,"name":"Mrvi1","annotation":"Protein MRVI1; Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO- dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation."},{"id":"ENSMUSP00000127838","abundance":1.4,"rank":9717,"name":"Vmn2r16","annotation":"Vomeronasal 2, receptor 16."},{"id":"ENSMUSP00000070137","abundance":1.4,"rank":9718,"name":"Tmem45a2","annotation":"Transmembrane protein 45A2."},{"id":"ENSMUSP00000148081","abundance":1.4,"rank":9719,"name":"Vmn1r72","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000021631","abundance":1.4,"rank":9720,"name":"Ppp4r4","annotation":"Serine/threonine-protein phosphatase 4 regulatory subunit 4; Putative regulatory subunit of serine/threonine-protein phosphatase 4."},{"id":"ENSMUSP00000059330","abundance":1.4,"rank":9721,"name":"Rbm15b","annotation":"Putative RNA-binding protein 15B; RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex. Involved in random X inactiva [...] "},{"id":"ENSMUSP00000090328","abundance":1.4,"rank":9722,"name":"Taar7b","annotation":"Trace amine-associated receptor 7b; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000139427","abundance":1.4,"rank":9723,"name":"Pik3r4","annotation":"Phosphoinositide 3-kinase regulatory subunit 4; Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity)."},{"id":"ENSMUSP00000058109","abundance":1.4,"rank":9724,"name":"Trim56","annotation":"E3 ubiquitin-protein ligase TRIM56; E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity. In response to pathogen- and host-derived double- stranded DNA (dsDNA), targets STING1 to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta. Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RAN [...] "},{"id":"ENSMUSP00000112616","abundance":1.4,"rank":9725,"name":"Ano1","annotation":"Anoctamin-1; Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Belongs to the anoctamin family."},{"id":"ENSMUSP00000131717","abundance":1.4,"rank":9726,"name":"BC030500","annotation":"cDNA sequence BC030500."},{"id":"ENSMUSP00000022032","abundance":1.4,"rank":9727,"name":"2210016F16Rik","annotation":"Queuosine salvage protein; Involved in salvaging queuosine."},{"id":"ENSMUSP00000010049","abundance":1.4,"rank":9728,"name":"Kdsr","annotation":"3-ketodihydrosphingosine reductase; Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS); Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000019878","abundance":1.4,"rank":9729,"name":"Leng1","annotation":"Leukocyte receptor cluster member 1 homolog."},{"id":"ENSMUSP00000029900","abundance":1.4,"rank":9730,"name":"Atp6v0d2","annotation":"V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). May play a role in coupling of proton transport and ATP hydrolysis. Regulator of osteoclast fusion and bone formation. Belongs to the V-ATPase V0D/AC39 subunit family."},{"id":"ENSMUSP00000043682","abundance":1.4,"rank":9731,"name":"Fbrs","annotation":"Probable fibrosin-1."},{"id":"ENSMUSP00000100553","abundance":1.4,"rank":9732,"name":"Capns2","annotation":"Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity)."},{"id":"ENSMUSP00000069947","abundance":1.4,"rank":9733,"name":"Rtl6","annotation":"Retrotransposon Gag-like protein 6."},{"id":"ENSMUSP00000139641","abundance":1.4,"rank":9734,"name":"Atg9a","annotation":"Autophagy-related protein 9A; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between a juxta-nuclear trans-Golgi network compartment and late endosomes. Nutrient starvation induces accumulation on autophagosomes. Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H (By similarity). Required for carbonyl cyanide m-chlorophenylhydrazone (CCCP)-induced ATG8 family protei [...] "},{"id":"ENSMUSP00000094193","abundance":1.4,"rank":9735,"name":"Rhox7a","annotation":"Reproductive homeobox 7A."},{"id":"ENSMUSP00000104311","abundance":1.4,"rank":9736,"name":"Arhgef15","annotation":"Rho guanine nucleotide exchange factor 15; Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse- promoting activity of EPHB2."},{"id":"ENSMUSP00000036487","abundance":1.4,"rank":9737,"name":"Ctnnal1","annotation":"Alpha-catulin; May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1)."},{"id":"ENSMUSP00000069083","abundance":1.4,"rank":9738,"name":"Mill1","annotation":"MHC I-like leukocyte 1; Belongs to the MHC class I family."},{"id":"ENSMUSP00000073188","abundance":1.4,"rank":9739,"name":"Nr1h2","annotation":"Oxysterols receptor LXR-beta; Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acut [...] "},{"id":"ENSMUSP00000067662","abundance":1.4,"rank":9740,"name":"Rdh8","annotation":"Retinol dehydrogenase 8; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000140416","abundance":1.4,"rank":9741,"name":"Cysrt1","annotation":"Cysteine-rich tail protein 1; Belongs to the CYSRT1 family."},{"id":"ENSMUSP00000091799","abundance":1.4,"rank":9742,"name":"Cldn3","annotation":"Claudin-3; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family."},{"id":"ENSMUSP00000034431","abundance":1.39,"rank":9743,"name":"Tmem170","annotation":"Transmembrane protein 170A; Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins."},{"id":"ENSMUSP00000094076","abundance":1.39,"rank":9744,"name":"Maff","annotation":"Transcription factor MafF; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition."},{"id":"ENSMUSP00000020375","abundance":1.39,"rank":9745,"name":"Rab3ip","annotation":"Rab-3A-interacting protein; Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface forma [...] "},{"id":"ENSMUSP00000124647","abundance":1.39,"rank":9746,"name":"Abcg4","annotation":"ATP-binding cassette transporter sub-family G member 4."},{"id":"ENSMUSP00000027425","abundance":1.39,"rank":9747,"name":"Itm2c","annotation":"Integral membrane protein 2C; Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation."},{"id":"ENSMUSP00000096578","abundance":1.39,"rank":9748,"name":"Cep295","annotation":"Centrosomal protein of 295 kDa; Centriole-enriched microtubule-binding protein involved in centriole biogenesis. Essential for the generation of the distal portion of new-born centrioles in a CENPJ- and CEP120-mediated elongation dependent manner during the cell cycle S/G2 phase after formation of the initiating cartwheel structure. Required for the recruitment of centriolar proteins, such as POC1B, POC5 and CEP135, into the distal portion of centrioles. Also required for centriole-to- centrosome conversion during mitotic progression, but is dispensable for cartwheel removal or centrio [...] "},{"id":"ENSMUSP00000020965","abundance":1.39,"rank":9749,"name":"Allc","annotation":"Probable allantoicase; The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals."},{"id":"ENSMUSP00000111418","abundance":1.39,"rank":9750,"name":"Ccnb3","annotation":"G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I (By similarity)."},{"id":"ENSMUSP00000064330","abundance":1.39,"rank":9751,"name":"Pank4","annotation":"4'-phosphopantetheine phosphatase; May play a role in the physiological regulation of coenzyme A (CoA) intracellular levels. The phosphatase activity shows preference for normal or oxidatively damaged intermediates of 4'- phosphopantetheine, which provides strong indirect evidence that the phosphatase activity pre-empts damage in the CoA pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their co [...] "},{"id":"ENSMUSP00000095137","abundance":1.39,"rank":9752,"name":"Mbd1","annotation":"Methyl-CpG-binding domain protein 1; Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylat [...] "},{"id":"ENSMUSP00000097153","abundance":1.39,"rank":9753,"name":"Pak6","annotation":"Serine/threonine-protein kinase PAK 6; Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR- mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD (By similarity); Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase fam [...] "},{"id":"ENSMUSP00000096751","abundance":1.39,"rank":9754,"name":"Tmem267","annotation":"Transmembrane protein 267."},{"id":"ENSMUSP00000136222","abundance":1.39,"rank":9755,"name":"Mdn1","annotation":"Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family."},{"id":"ENSMUSP00000083971","abundance":1.39,"rank":9756,"name":"Adgre1","annotation":"Adhesion G protein-coupled receptor E1; Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development."},{"id":"ENSMUSP00000084095","abundance":1.39,"rank":9757,"name":"Asb18","annotation":"Ankyrin repeat and SOCS box protein 18; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family."},{"id":"ENSMUSP00000016638","abundance":1.39,"rank":9758,"name":"Cd34","annotation":"Hematopoietic progenitor cell antigen CD34; Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins (By similarity). Belongs to the CD34 family."},{"id":"ENSMUSP00000148014","abundance":1.39,"rank":9759,"name":"Prrg2","annotation":"Transmembrane gamma-carboxyglutamic acid protein 2."},{"id":"ENSMUSP00000099660","abundance":1.39,"rank":9760,"name":"Fndc5","annotation":"Fibronectin type III domain-containing protein 5; [Irisin]: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA."},{"id":"ENSMUSP00000149072","abundance":1.39,"rank":9761,"name":"Olfr1249","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000034717","abundance":1.39,"rank":9762,"name":"Kank2","annotation":"KN motif and ankyrin repeat domain-containing protein 2; Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3 (By similarity). Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria (By similarity). Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis (By similarity). Involved in the negative control of vitamin D receptor signaling pathway (By similarity). Involved in a [...] "},{"id":"ENSMUSP00000157872","abundance":1.39,"rank":9763,"name":"Vmn1r232","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000030741","abundance":1.39,"rank":9764,"name":"Ptpru","annotation":"Receptor-type tyrosine-protein phosphatase U; Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily."},{"id":"ENSMUSP00000110219","abundance":1.39,"rank":9765,"name":"Krba1","annotation":"Protein KRBA1."},{"id":"ENSMUSP00000021453","abundance":1.38,"rank":9766,"name":"Tex21","annotation":"Testis-expressed gene 21."},{"id":"ENSMUSP00000109339","abundance":1.38,"rank":9767,"name":"Slc7a3","annotation":"Cationic amino acid transporter 3; Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner."},{"id":"ENSMUSP00000067786","abundance":1.38,"rank":9768,"name":"Sos1","annotation":"Son of sevenless homolog 1; Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF (By similarity). Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity."},{"id":"ENSMUSP00000052258","abundance":1.38,"rank":9769,"name":"Amfr","annotation":"E3 ubiquitin-protein ligase AMFR; E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum- associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into t [...] "},{"id":"ENSMUSP00000030360","abundance":1.38,"rank":9770,"name":"Lrrc42","annotation":"Leucine-rich repeat-containing protein 42; Belongs to the LRRC42 family."},{"id":"ENSMUSP00000107890","abundance":1.38,"rank":9771,"name":"Ace2","annotation":"Processed angiotensin-converting enzyme 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator (By similarity). Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency (By similarity). By cleavage of angiotensin II, may be an important regulator of heart function. By cleavage of angiotensin II, may also have a protective role in acute lung injury. Plays an important role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19, regulating its tr [...] "},{"id":"ENSMUSP00000124406","abundance":1.38,"rank":9772,"name":"Fancc","annotation":"Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1 (By similarity)."},{"id":"ENSMUSP00000029927","abundance":1.38,"rank":9773,"name":"Spaca1","annotation":"Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility."},{"id":"ENSMUSP00000053157","abundance":1.38,"rank":9774,"name":"Scml4","annotation":"Sex comb on midleg-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity)."},{"id":"ENSMUSP00000057362","abundance":1.38,"rank":9775,"name":"Msantd1","annotation":"Myb/SANT-like DNA-binding domain-containing protein 1."},{"id":"ENSMUSP00000074340","abundance":1.38,"rank":9776,"name":"Hmcn1","annotation":"Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration."},{"id":"ENSMUSP00000056313","abundance":1.38,"rank":9777,"name":"Nyx","annotation":"Nyctalopin; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily."},{"id":"ENSMUSP00000028593","abundance":1.38,"rank":9778,"name":"Prrg4","annotation":"Transmembrane gamma-carboxyglutamic acid protein 4; May control axon guidance across the CNS (By similarity). Prevents the delivery of ROBO1 at the cell surface and downregulates its expression (By similarity)."},{"id":"ENSMUSP00000054852","abundance":1.38,"rank":9779,"name":"Xbp1","annotation":"X-box-binding protein 1, cytoplasmic form; Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility  [...] "},{"id":"ENSMUSP00000019977","abundance":1.38,"rank":9780,"name":"Ddo","annotation":"D-aspartate oxidase; Selectively catalyzes the oxidative deamination of D- aspartate and its N-methylated derivative, N-methyl D-aspartate. Belongs to the DAMOX/DASOX family."},{"id":"ENSMUSP00000027414","abundance":1.38,"rank":9781,"name":"Stk11ip","annotation":"Serine/threonine-protein kinase 11-interacting protein; May regulate STK11/LKB1 function by controlling its subcellular localization."},{"id":"ENSMUSP00000084663","abundance":1.38,"rank":9782,"name":"Morc4","annotation":"MORC family CW-type zinc finger protein 4."},{"id":"ENSMUSP00000003444","abundance":1.38,"rank":9783,"name":"Ccdc65","annotation":"Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N- DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules; Belongs to the DRC2 family."},{"id":"ENSMUSP00000076578","abundance":1.38,"rank":9784,"name":"Cyp2b23","annotation":"Cytochrome P450, family 2, subfamily b, polypeptide 23; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000041236","abundance":1.38,"rank":9785,"name":"Zc4h2","annotation":"Zinc finger C4H2 domain-containing protein; Plays a role in interneurons differentiation. Involved in neuronal development and in neuromuscular junction formation."},{"id":"ENSMUSP00000021941","abundance":1.37,"rank":9786,"name":"Mxd3","annotation":"Max dimerization protein 3; Transcriptional repressor. Binds with MAX to form a sequence- specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation."},{"id":"ENSMUSP00000052208","abundance":1.37,"rank":9787,"name":"Fam124b","annotation":"Protein FAM124B; Belongs to the FAM124 family."},{"id":"ENSMUSP00000031434","abundance":1.37,"rank":9788,"name":"Rnf34","annotation":"E3 ubiquitin-protein ligase RNF34; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway. Negatively regulates p5 [...] "},{"id":"ENSMUSP00000000003","abundance":1.37,"rank":9789,"name":"Pbsn","annotation":"Probasin."},{"id":"ENSMUSP00000028983","abundance":1.37,"rank":9790,"name":"Bpifb2","annotation":"BPI fold-containing family B member 2."},{"id":"ENSMUSP00000095823","abundance":1.37,"rank":9791,"name":"Olfr555","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000143172","abundance":1.37,"rank":9792,"name":"Olfr576","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000039915","abundance":1.37,"rank":9793,"name":"Dcbld2","annotation":"Discoidin, CUB and LCCL domain-containing protein 2."},{"id":"ENSMUSP00000074594","abundance":1.37,"rank":9794,"name":"Trim58","annotation":"E3 ubiquitin-protein ligase TRIM58; E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization."},{"id":"ENSMUSP00000109154","abundance":1.37,"rank":9795,"name":"Gpha2","annotation":"Glycoprotein hormone alpha-2; Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production. Plays a central role in controlling thyroid cell metabolism."},{"id":"ENSMUSP00000122192","abundance":1.37,"rank":9796,"name":"Megf8","annotation":"Multiple epidermal growth factor-like domains protein 8; Acts as a negative regulator of hedgehog signaling."},{"id":"ENSMUSP00000024894","abundance":1.37,"rank":9797,"name":"Cyp1b1","annotation":"Cytochrome P450 1B1; A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (By similarity). Exhibits catalytic activity for the formation of hydroxyestrogens from 17beta-estradiol (E2), namely 2- and 4-hydroxy E2. Metabolizes testosterone and progesterone [...] "},{"id":"ENSMUSP00000050451","abundance":1.37,"rank":9798,"name":"Tmem198b","annotation":"Transmembrane protein 198b."},{"id":"ENSMUSP00000050818","abundance":1.37,"rank":9799,"name":"Igbp1b","annotation":"Immunoglobulin-binding protein 1b; Associated to surface IgM-receptor; may be involved in signal transduction (By similarity). May be involved in regulation of the catalytic activity of type 2A-related serine/threonine phosphatases. Belongs to the IGBP1/TAP42 family."},{"id":"ENSMUSP00000062790","abundance":1.37,"rank":9800,"name":"Phxr2","annotation":"Putative per-hexamer repeat protein 2."},{"id":"ENSMUSP00000113895","abundance":1.37,"rank":9801,"name":"N4bp2l2","annotation":"NEDD4-binding protein 2-like 2."},{"id":"ENSMUSP00000102703","abundance":1.37,"rank":9802,"name":"Slco2b1","annotation":"Solute carrier organic anion transporter family member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost; Belongs to the organo anion transporter (TC 2.A.60) family."},{"id":"ENSMUSP00000076026","abundance":1.37,"rank":9803,"name":"Dsg1b","annotation":"Desmoglein-1-beta; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion."},{"id":"ENSMUSP00000039568","abundance":1.37,"rank":9804,"name":"Sec22a","annotation":"Vesicle-trafficking protein SEC22a; May be involved in vesicle transport between the ER and the Golgi complex; Belongs to the synaptobrevin family."},{"id":"ENSMUSP00000050836","abundance":1.37,"rank":9805,"name":"Wfdc12","annotation":"WAP four-disulfide core domain protein 12; Antibacterial protein which inhibits the growth of E.coli and S.aureus. Putative acid-stable proteinase inhibitor."},{"id":"ENSMUSP00000097185","abundance":1.37,"rank":9806,"name":"Chrm5","annotation":"Muscarinic acetylcholine receptor M5; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity); Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily."},{"id":"ENSMUSP00000139357","abundance":1.37,"rank":9807,"name":"Nlrp6","annotation":"NACHT, LRR and PYD domains-containing protein 6; As the sensor component of the NLRP6 inflammasome, plays a crucial role in innate immunity and inflammation. In response to yet unidentified signals, initiates the formation of the inflammasome polymeric complex, made of NLRP6, PYCARD and CASP1 (or possibly CASP4/CASP11). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. The precise NLRP6 activation stimulus has not been identified yet (By similarity). Essential for gut mucosal self- [...] "},{"id":"ENSMUSP00000095501","abundance":1.37,"rank":9808,"name":"Sh3d21","annotation":"SH3 domain-containing protein 21."},{"id":"ENSMUSP00000051335","abundance":1.37,"rank":9809,"name":"Zfpm2","annotation":"Zinc finger protein ZFPM2; Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2."},{"id":"ENSMUSP00000021056","abundance":1.37,"rank":9810,"name":"Scn4a","annotation":"Sodium channel protein type 4 subunit alpha; Pore-forming subunit of a voltage-gated sodium channel complex through which Na(+) ions pass in accordance with their electrochemical gradient. Alternates between resting, activated and inactivated states. Required for normal muscle fiber excitability, normal muscle contraction and relaxation cycles, and constant muscle strength in the presence of fluctuating K(+) levels."},{"id":"ENSMUSP00000002655","abundance":1.37,"rank":9811,"name":"Mien1","annotation":"Migration and invasion enhancer 1; Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process (By similarity)."},{"id":"ENSMUSP00000048508","abundance":1.37,"rank":9812,"name":"Gbx2","annotation":"Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo."},{"id":"ENSMUSP00000002305","abundance":1.37,"rank":9813,"name":"Kdm7a","annotation":"Lysine-specific demethylase 7A; Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4 [...] "},{"id":"ENSMUSP00000097897","abundance":1.37,"rank":9814,"name":"Slitrk1","annotation":"SLIT and NTRK-like protein 1; It is involved in synaptogenesis and promotes excitatory synapse differentiation (By similarity). Enhances neuronal dendrite outgrowth ; Belongs to the SLITRK family."},{"id":"ENSMUSP00000117017","abundance":1.37,"rank":9815,"name":"Igsf9b","annotation":"Protein turtle homolog B; Transmembrane protein which is abundantly expressed in interneurons, where it may regulate inhibitory synapse development (By similarity). May mediate homophilic cell adhesion."},{"id":"ENSMUSP00000079692","abundance":1.36,"rank":9816,"name":"Pfkfb1","annotation":"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1; Synthesis and degradation of fructose 2,6-bisphosphate."},{"id":"ENSMUSP00000098112","abundance":1.36,"rank":9817,"name":"Agfg2","annotation":"Arf-GAP domain and FG repeat-containing protein 2."},{"id":"ENSMUSP00000050199","abundance":1.36,"rank":9818,"name":"Tafa2","annotation":"Chemokine-like protein TAFA-2; Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions."},{"id":"ENSMUSP00000125427","abundance":1.36,"rank":9819,"name":"Tyw5","annotation":"tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes (By similarity); Belongs to the TYW5 family."},{"id":"ENSMUSP00000159063","abundance":1.36,"rank":9820,"name":"Amz2","annotation":"Archaemetzincin-2; Zinc metalloprotease. Exhibits activity against angiotensin-3 in vitro. Does not hydrolyze neurogranin nor angiotensin-2 (By similarity); Belongs to the peptidase M54 family."},{"id":"ENSMUSP00000050267","abundance":1.36,"rank":9821,"name":"Triml1","annotation":"Probable E3 ubiquitin-protein ligase TRIML1; Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development. Involved in progression of blastocyst stage and subsequent embryo development."},{"id":"ENSMUSP00000020112","abundance":1.36,"rank":9822,"name":"Uhrf1bp1l","annotation":"UHRF1-binding protein 1-like."},{"id":"ENSMUSP00000062632","abundance":1.36,"rank":9823,"name":"Exph5","annotation":"Exophilin-5; May act as Rab effector protein and play a role in vesicle trafficking."},{"id":"ENSMUSP00000026557","abundance":1.36,"rank":9824,"name":"Bet1l","annotation":"BET1-like protein; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity)."},{"id":"ENSMUSP00000040403","abundance":1.36,"rank":9825,"name":"Alkbh4","annotation":"Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4; Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (By similarity). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing ; Belongs to  [...] "},{"id":"ENSMUSP00000026295","abundance":1.36,"rank":9826,"name":"Tsr2","annotation":"Pre-rRNA-processing protein TSR2 homolog; May be involved in 20S pre-rRNA processing."},{"id":"ENSMUSP00000047953","abundance":1.36,"rank":9827,"name":"Iqch","annotation":"IQ domain-containing protein H; May play a regulatory role in spermatogenesis."},{"id":"ENSMUSP00000032551","abundance":1.36,"rank":9828,"name":"Zik1","annotation":"Zinc finger protein interacting with ribonucleoprotein K; May be a transcriptional repressor. Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000062395","abundance":1.36,"rank":9829,"name":"C77080","annotation":"Uncharacterized protein KIAA1522."},{"id":"ENSMUSP00000112597","abundance":1.36,"rank":9830,"name":"Slc5a2","annotation":"Sodium/glucose cotransporter 2; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family."},{"id":"ENSMUSP00000066679","abundance":1.36,"rank":9831,"name":"Chek2","annotation":"Serine/threonine-protein kinase Chk2; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads  [...] "},{"id":"ENSMUSP00000062719","abundance":1.36,"rank":9832,"name":"Taar8a","annotation":"Trace amine-associated receptor 8a; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000103406","abundance":1.36,"rank":9833,"name":"Tdrd7","annotation":"Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis; Belongs to the TDRD7 family."},{"id":"ENSMUSP00000045668","abundance":1.36,"rank":9834,"name":"Ushbp1","annotation":"Usher syndrome type-1C protein-binding protein 1."},{"id":"ENSMUSP00000110414","abundance":1.36,"rank":9835,"name":"Map7d3","annotation":"MAP7 domain-containing protein 3; Promotes the assembly and stability of microtubules. Belongs to the MAP7 family."},{"id":"ENSMUSP00000095677","abundance":1.36,"rank":9836,"name":"Zfp462","annotation":"Zinc finger protein 462; Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation."},{"id":"ENSMUSP00000109899","abundance":1.36,"rank":9837,"name":"Paxx","annotation":"Protein PAXX; Involved in non-homologous end joining (NHEJ), a major pathway to repair double-strand breaks in DNA. May act as a scaffold required to stabilize the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at DNA ends and thus promote assembly and/or stability of the NHEJ machinery at double-strand break sites."},{"id":"ENSMUSP00000019998","abundance":1.36,"rank":9838,"name":"Perp","annotation":"P53 apoptosis effector related to PMP-22; Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway."},{"id":"ENSMUSP00000075074","abundance":1.36,"rank":9839,"name":"Rnase2b","annotation":"Ribonuclease 2B; This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities."},{"id":"ENSMUSP00000027564","abundance":1.36,"rank":9840,"name":"Serpinb13","annotation":"Serpin B13; May play a role in the proliferation or differentiation of keratinocytes."},{"id":"ENSMUSP00000091511","abundance":1.36,"rank":9841,"name":"Arsj","annotation":"Arylsulfatase J."},{"id":"ENSMUSP00000064336","abundance":1.36,"rank":9842,"name":"Tnrc6b","annotation":"Trinucleotide repeat-containing gene 6B protein; Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA- dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (By similarity); Belongs to the GW182 family."},{"id":"ENSMUSP00000064422","abundance":1.36,"rank":9843,"name":"Zfp395","annotation":"Zinc finger protein 395."},{"id":"ENSMUSP00000102320","abundance":1.36,"rank":9844,"name":"Podn","annotation":"Podocan; Negatively regulates cell proliferation and cell migration, especially in smooth muscle cells."},{"id":"ENSMUSP00000062780","abundance":1.36,"rank":9845,"name":"Nap1l5","annotation":"Nucleosome assembly protein 1-like 5."},{"id":"ENSMUSP00000097442","abundance":1.36,"rank":9846,"name":"Mtr","annotation":"Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity)."},{"id":"ENSMUSP00000102481","abundance":1.36,"rank":9847,"name":"Wdr78","annotation":"WD repeat-containing protein 78."},{"id":"ENSMUSP00000131665","abundance":1.36,"rank":9848,"name":"Nell2","annotation":"Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity)."},{"id":"ENSMUSP00000062864","abundance":1.36,"rank":9849,"name":"Pik3cg","annotation":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates [...] "},{"id":"ENSMUSP00000105923","abundance":1.35,"rank":9850,"name":"Elmsan1","annotation":"ELM2 and Myb/SANT-like domain-containing 1."},{"id":"ENSMUSP00000104223","abundance":1.35,"rank":9851,"name":"Kmt5c","annotation":"Histone-lysine N-methyltransferase KMT5C; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] "},{"id":"ENSMUSP00000151115","abundance":1.35,"rank":9852,"name":"Olfr978","annotation":"Olfactory receptor 978."},{"id":"ENSMUSP00000105493","abundance":1.35,"rank":9853,"name":"Znrf3","annotation":"E3 ubiquitin-protein ligase ZNRF3; E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone. Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification (By similarity)."},{"id":"ENSMUSP00000041306","abundance":1.35,"rank":9854,"name":"Oscar","annotation":"Osteoclast-associated immunoglobulin-like receptor; Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation. Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family."},{"id":"ENSMUSP00000076115","abundance":1.35,"rank":9855,"name":"Efna5","annotation":"Ephrin-A5; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like memb [...] "},{"id":"ENSMUSP00000033211","abundance":1.35,"rank":9856,"name":"Trim30d","annotation":"Tripartite motif-containing 30D."},{"id":"ENSMUSP00000148042","abundance":1.35,"rank":9857,"name":"Grtp1","annotation":"Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s)."},{"id":"ENSMUSP00000070119","abundance":1.35,"rank":9858,"name":"Doc2a","annotation":"Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells."},{"id":"ENSMUSP00000094078","abundance":1.35,"rank":9859,"name":"Magee1","annotation":"Melanoma-associated antigen E1; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (By similarity)."},{"id":"ENSMUSP00000006786","abundance":1.35,"rank":9860,"name":"Slc17a2","annotation":"Sodium-dependent phosphate transport protein 3; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (By similarity). Belongs to the major facilitator superfamily. Sodium/anion cotransporter family."},{"id":"ENSMUSP00000049039","abundance":1.35,"rank":9861,"name":"Arx","annotation":"Homeobox protein ARX; Transcription factor required for normal brain development. May be important for maintenance of specific neuronal subtypes in the cerebral cortex and axonal guidance in the floor plate (By similarity). Belongs to the paired homeobox family. Bicoid subfamily."},{"id":"ENSMUSP00000111479","abundance":1.35,"rank":9862,"name":"Pik3c3","annotation":"Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] "},{"id":"ENSMUSP00000131062","abundance":1.35,"rank":9863,"name":"Sept12","annotation":"Septin 12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family."},{"id":"ENSMUSP00000019266","abundance":1.35,"rank":9864,"name":"Ccl9","annotation":"C-C motif chemokine 9; Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors; Belongs to the intercrine beta (chemokine CC) family."},{"id":"ENSMUSP00000077139","abundance":1.35,"rank":9865,"name":"Tmc2","annotation":"Transmembrane channel-like protein 2; Probable ion channel required for the normal function of cochlear hair cells (By similarity). Component of the hair cell's mechanotransduction (MET) machinery. Involved in mechanosensitive responses of the hair cells (By similarity)."},{"id":"ENSMUSP00000147568","abundance":1.35,"rank":9866,"name":"Gm10153","annotation":"Predicted gene 10153."},{"id":"ENSMUSP00000062843","abundance":1.35,"rank":9867,"name":"Mcmbp","annotation":"Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity)."},{"id":"ENSMUSP00000101500","abundance":1.35,"rank":9868,"name":"Slc30a2","annotation":"Zinc transporter 2; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily."},{"id":"ENSMUSP00000029625","abundance":1.35,"rank":9869,"name":"Sfrp2","annotation":"Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis."},{"id":"ENSMUSP00000075526","abundance":1.35,"rank":9870,"name":"Mtx3","annotation":"Metaxin."},{"id":"ENSMUSP00000053013","abundance":1.35,"rank":9871,"name":"Zfp691","annotation":"Zinc finger protein 691; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000018431","abundance":1.35,"rank":9872,"name":"Spag7","annotation":"Sperm-associated antigen 7."},{"id":"ENSMUSP00000034163","abundance":1.35,"rank":9873,"name":"Zfp821","annotation":"Zinc finger protein 821; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000053181","abundance":1.35,"rank":9874,"name":"Slc30a10","annotation":"Zinc transporter 10; Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death. Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recyc [...] "},{"id":"ENSMUSP00000035642","abundance":1.35,"rank":9875,"name":"Ppp1r14a","annotation":"Protein phosphatase 1 regulatory subunit 14A; Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity)."},{"id":"ENSMUSP00000101256","abundance":1.35,"rank":9876,"name":"Plch2","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain."},{"id":"ENSMUSP00000076700","abundance":1.35,"rank":9877,"name":"Zfp953","annotation":"Zinc finger protein 953."},{"id":"ENSMUSP00000026988","abundance":1.35,"rank":9878,"name":"Arl10","annotation":"ADP-ribosylation factor-like protein 10; Belongs to the small GTPase superfamily. Arf family."},{"id":"ENSMUSP00000023113","abundance":1.34,"rank":9879,"name":"Polr3h","annotation":"DNA-directed RNA polymerase III subunit RPC8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNA. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type  [...] "},{"id":"ENSMUSP00000031985","abundance":1.34,"rank":9880,"name":"Mkrn1","annotation":"E3 ubiquitin-protein ligase makorin-1; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase (By similarity). Has negative and positive effects on RNA polymerase II-dependent transcription."},{"id":"ENSMUSP00000107572","abundance":1.34,"rank":9881,"name":"Rgs13","annotation":"Regulator of G-protein signaling 13; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha."},{"id":"ENSMUSP00000016094","abundance":1.34,"rank":9882,"name":"Ncf1","annotation":"Neutrophil cytosol factor 1; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)."},{"id":"ENSMUSP00000053979","abundance":1.34,"rank":9883,"name":"Zfp959","annotation":"Zinc finger protein 959."},{"id":"ENSMUSP00000070592","abundance":1.34,"rank":9884,"name":"Slain1","annotation":"SLAIN motif-containing protein 1; Microtubule plus-end tracking protein that might be involved in the regulation of cytoplasmic microtubule dynamics, microtubule organization and microtubule elongation; Belongs to the SLAIN motif-containing family."},{"id":"ENSMUSP00000062759","abundance":1.34,"rank":9885,"name":"Sox18","annotation":"Transcription factor SOX-18; Transcriptional activator that binds to the consensus sequence 5'-AACAAAG-3' in the promoter of target genes and plays an essential role in embryonic cardiovascular development and lymphangiogenesis. Activates transcription of PROX1 and other genes coding for lymphatic endothelial markers. Plays an essential role in triggering the differentiation of lymph vessels, but is not required for the maintenance of differentiated lymphatic endothelial cells. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX17. Interaction [...] "},{"id":"ENSMUSP00000047782","abundance":1.34,"rank":9886,"name":"Slfn1","annotation":"Schlafen family member 1."},{"id":"ENSMUSP00000103742","abundance":1.34,"rank":9887,"name":"Spry1","annotation":"Protein sprouty homolog 1; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Belongs to the sprouty family."},{"id":"ENSMUSP00000111189","abundance":1.34,"rank":9888,"name":"Fam133b","annotation":"Protein FAM133B; Belongs to the FAM133 family."},{"id":"ENSMUSP00000007747","abundance":1.34,"rank":9889,"name":"Dus3l","annotation":"tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs."},{"id":"ENSMUSP00000040568","abundance":1.34,"rank":9890,"name":"Armc5","annotation":"Armadillo repeat-containing protein 5; Involved in fetal development, T-cell function and adrenal gland growth homeostasis. Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (By similarity)."},{"id":"ENSMUSP00000022952","abundance":1.34,"rank":9891,"name":"Osr2","annotation":"Protein odd-skipped-related 2."},{"id":"ENSMUSP00000093908","abundance":1.34,"rank":9892,"name":"Cemip2","annotation":"Cell surface hyaluronidase; Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan of approximately 5 kDa fragments (By similarity). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (By similarity). Belongs to the CEMIP family."},{"id":"ENSMUSP00000110999","abundance":1.34,"rank":9893,"name":"Timp1","annotation":"Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (By similarity). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling; Belongs to the protease inhibitor I35  [...] "},{"id":"ENSMUSP00000109151","abundance":1.34,"rank":9894,"name":"Tmem63b","annotation":"CSC1-like protein 2; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family."},{"id":"ENSMUSP00000119875","abundance":1.34,"rank":9895,"name":"Pms2","annotation":"Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing th [...] "},{"id":"ENSMUSP00000104503","abundance":1.34,"rank":9896,"name":"Birc7","annotation":"Baculoviral IAP repeat-containing protein 7 30 kDa subunit; Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of caspase-3, -7, and -9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibit [...] "},{"id":"ENSMUSP00000101796","abundance":1.34,"rank":9897,"name":"1110065P20Rik","annotation":"Uncharacterized protein C1orf122 homolog."},{"id":"ENSMUSP00000026476","abundance":1.34,"rank":9898,"name":"Mbd6","annotation":"Methyl-CpG-binding domain protein 6; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro) (By similarity)."},{"id":"ENSMUSP00000020566","abundance":1.34,"rank":9899,"name":"Theg","annotation":"Testicular haploid expressed gene protein; May be involved (but not essential) in spermatogenesis."},{"id":"ENSMUSP00000101233","abundance":1.34,"rank":9900,"name":"Slc35e2","annotation":"Solute carrier family 35 member E2A; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily."},{"id":"ENSMUSP00000046776","abundance":1.34,"rank":9901,"name":"Prr7","annotation":"Proline-rich protein 7; Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (By similarity). Might play a redundant role in the regulation of T cell receptor signaling. Might promote apoptosis in T cells (By similarity)."},{"id":"ENSMUSP00000105613","abundance":1.34,"rank":9902,"name":"Ralgapa2","annotation":"Ral GTPase-activating protein subunit alpha-2; Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB."},{"id":"ENSMUSP00000086615","abundance":1.34,"rank":9903,"name":"Zfp120","annotation":"Zinc finger protein 120; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000020252","abundance":1.33,"rank":9904,"name":"Sycp3","annotation":"Synaptonemal complex protein 3; Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells. Required for normal meiosis during spermatogenesis and male fertility. Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2."},{"id":"ENSMUSP00000126838","abundance":1.33,"rank":9905,"name":"Slc43a2","annotation":"Large neutral amino acids transporter small subunit 4; Sodium-, chloride-, and pH-independent, high affinity transport of large neutral amino acids; Belongs to the SLC43A transporter (TC 2.A.1.44) family."},{"id":"ENSMUSP00000061402","abundance":1.33,"rank":9906,"name":"Ppp1r3d","annotation":"Protein phosphatase 1, regulatory subunit 3D."},{"id":"ENSMUSP00000001279","abundance":1.33,"rank":9907,"name":"Lsr","annotation":"Lipolysis-stimulated lipoprotein receptor; Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity)."},{"id":"ENSMUSP00000030170","abundance":1.33,"rank":9908,"name":"Unc13a","annotation":"Protein unc-13 homolog A; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA- mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. Also involved in  [...] "},{"id":"ENSMUSP00000005188","abundance":1.33,"rank":9909,"name":"Sh2b2","annotation":"SH2B adapter protein 2; Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity)."},{"id":"ENSMUSP00000078050","abundance":1.33,"rank":9910,"name":"Slc35e3","annotation":"Solute carrier family 35 member E3; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily."},{"id":"ENSMUSP00000014476","abundance":1.33,"rank":9911,"name":"Klra8","annotation":"Killer cell lectin-like receptor 8; Receptor on natural killer (NK) cells for class I MHC."},{"id":"ENSMUSP00000051809","abundance":1.33,"rank":9912,"name":"Rictor","annotation":"Rapamycin-insensitive companion of mTOR; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activa [...] "},{"id":"ENSMUSP00000150135","abundance":1.33,"rank":9913,"name":"Olfr1107","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000022600","abundance":1.33,"rank":9914,"name":"Mtrf1","annotation":"Peptide chain release factor 1, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-cognate termination stop codons AGG and AGA."},{"id":"ENSMUSP00000031224","abundance":1.33,"rank":9915,"name":"Tgfbr3","annotation":"Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors (By similarity)."},{"id":"ENSMUSP00000124709","abundance":1.33,"rank":9916,"name":"Grip2","annotation":"Glutamate receptor-interacting protein 2."},{"id":"ENSMUSP00000119518","abundance":1.33,"rank":9917,"name":"Fam111a","annotation":"Protein FAM111A; Chromatin-associated protein required for PCNA loading on replication sites. Promotes S-phase entry and DNA synthesis (By similarity); Belongs to the FAM111 family."},{"id":"ENSMUSP00000033160","abundance":1.33,"rank":9918,"name":"Gga2","annotation":"ADP-ribosylation factor-binding protein GGA2; Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network."},{"id":"ENSMUSP00000043087","abundance":1.33,"rank":9919,"name":"Cbfa2t2","annotation":"Protein CBFA2T2; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in re [...] "},{"id":"ENSMUSP00000125451","abundance":1.33,"rank":9920,"name":"Ciapin1","annotation":"Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] "},{"id":"ENSMUSP00000081745","abundance":1.33,"rank":9921,"name":"Galt","annotation":"Galactose-1-phosphate uridylyltransferase; Plays an important role in galactose metabolism."},{"id":"ENSMUSP00000127021","abundance":1.33,"rank":9922,"name":"Irf5","annotation":"Interferon regulatory factor 5; Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling (By similarity)."},{"id":"ENSMUSP00000004201","abundance":1.33,"rank":9923,"name":"Col5a3","annotation":"Collagen type V alpha 3 chain."},{"id":"ENSMUSP00000053123","abundance":1.33,"rank":9924,"name":"Lrrc4b","annotation":"Leucine-rich repeat-containing protein 4B; Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity)."},{"id":"ENSMUSP00000063314","abundance":1.33,"rank":9925,"name":"Gm13199","annotation":"Predicted gene 13199."},{"id":"ENSMUSP00000028795","abundance":1.33,"rank":9926,"name":"Rad51","annotation":"DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR  [...] "},{"id":"ENSMUSP00000151590","abundance":1.33,"rank":9927,"name":"Sbno2","annotation":"Protein strawberry notch homolog 2; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC- STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL- mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a  [...] "},{"id":"ENSMUSP00000011298","abundance":1.33,"rank":9928,"name":"Cfap161","annotation":"Cilia- and flagella-associated protein 161; May play a role in motile cilia function, possibly by acting on dynein arm assembly."},{"id":"ENSMUSP00000100675","abundance":1.33,"rank":9929,"name":"2300003K06Rik","annotation":"RIKEN cDNA 2300003K06 gene."},{"id":"ENSMUSP00000071836","abundance":1.33,"rank":9930,"name":"Tec","annotation":"Tyrosine-protein kinase Tec; Non-receptor tyrosine kinase that contributes to signaling from many receptors and participates as a signal transducer in multiple downstream pathways, including regulation of the actin cytoskeleton. Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR- dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate  [...] "},{"id":"ENSMUSP00000032080","abundance":1.32,"rank":9931,"name":"Pradc1","annotation":"Protease-associated domain-containing protein 1."},{"id":"ENSMUSP00000059320","abundance":1.32,"rank":9932,"name":"Tmco4","annotation":"Transmembrane and coiled-coil domain-containing protein 4; Belongs to the TMCO4 family."},{"id":"ENSMUSP00000117263","abundance":1.32,"rank":9933,"name":"Lrrtm4","annotation":"Leucine-rich repeat transmembrane neuronal protein 4; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity)."},{"id":"ENSMUSP00000096113","abundance":1.32,"rank":9934,"name":"Plekhf1","annotation":"Pleckstrin homology domain-containing family F member 1; May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity)."},{"id":"ENSMUSP00000045988","abundance":1.32,"rank":9935,"name":"Nemp1","annotation":"Nuclear envelope integral membrane protein 1."},{"id":"ENSMUSP00000054158","abundance":1.32,"rank":9936,"name":"Mycs","annotation":"Protein S-Myc; Has apoptosis-inducing activity."},{"id":"ENSMUSP00000149214","abundance":1.32,"rank":9937,"name":"Csrnp1","annotation":"Cysteine/serine-rich nuclear protein 1; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. May have a tumor-suppressor function. May play a role in apoptosis."},{"id":"ENSMUSP00000029143","abundance":1.32,"rank":9938,"name":"Fam83c","annotation":"Protein FAM83C; May play a role in MAPK signaling. Belongs to the FAM83 family."},{"id":"ENSMUSP00000045550","abundance":1.32,"rank":9939,"name":"Zfp410","annotation":"Zinc finger protein 410; Transcription factor that activates transcription of matrix- remodeling genes such as MMP1 during fibroblast senescence."},{"id":"ENSMUSP00000037476","abundance":1.32,"rank":9940,"name":"Tmem30b","annotation":"Cell cycle control protein 50B; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to th [...] "},{"id":"ENSMUSP00000112338","abundance":1.32,"rank":9941,"name":"Prr16","annotation":"Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration (Probable)."},{"id":"ENSMUSP00000065935","abundance":1.32,"rank":9942,"name":"Slc20a2","annotation":"Sodium-dependent phosphate transporter 2; Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retrovi [...] "},{"id":"ENSMUSP00000092904","abundance":1.32,"rank":9943,"name":"Slc26a10","annotation":"Solute carrier family 26 member 10; Chloride/bicarbonate exchanger; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family."},{"id":"ENSMUSP00000105096","abundance":1.32,"rank":9944,"name":"Mpped1","annotation":"Metallophosphoesterase domain-containing protein 1; May have metallophosphoesterase activity (in vitro)."},{"id":"ENSMUSP00000071626","abundance":1.32,"rank":9945,"name":"Tas2r120","annotation":"Taste receptor type 2 member 120; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000118474","abundance":1.32,"rank":9946,"name":"Rnf44","annotation":"RING finger protein 44."},{"id":"ENSMUSP00000067217","abundance":1.32,"rank":9947,"name":"Cdc42ep3","annotation":"Cdc42 effector protein 3; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts (By similarity)."},{"id":"ENSMUSP00000059978","abundance":1.32,"rank":9948,"name":"Rab11fip2","annotation":"Rab11 family-interacting protein 2; A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator  [...] "},{"id":"ENSMUSP00000152821","abundance":1.32,"rank":9949,"name":"Adck1","annotation":"AarF domain-containing protein kinase 1; Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase- independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (By similarity). The action of this enzyme is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable)."},{"id":"ENSMUSP00000026121","abundance":1.32,"rank":9950,"name":"Ppp1r27","annotation":"Protein phosphatase 1 regulatory subunit 27; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes."},{"id":"ENSMUSP00000024944","abundance":1.32,"rank":9951,"name":"Slc3a1","annotation":"Neutral and basic amino acid transport protein rBAT; Involved in the high-affinity sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney proximal tubule."},{"id":"ENSMUSP00000033839","abundance":1.32,"rank":9952,"name":"Coprs","annotation":"Coordinator of PRMT5 and differentiation stimulator; Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modula [...] "},{"id":"ENSMUSP00000132382","abundance":1.32,"rank":9953,"name":"Gm3239","annotation":"Predicted gene 3239."},{"id":"ENSMUSP00000027769","abundance":1.32,"rank":9954,"name":"Tfb2m","annotation":"Dimethyladenosine transferase 2, mitochondrial; S-adenosyl-L-methionine-dependent rRNA methyltransferase which may methylate two specific adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 12S mitochondrial rRNA (By similarity). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-t [...] "},{"id":"ENSMUSP00000082763","abundance":1.32,"rank":9955,"name":"Scgb2b26","annotation":"Salivary androgen-binding protein gamma subunit."},{"id":"ENSMUSP00000128672","abundance":1.32,"rank":9956,"name":"Megf11","annotation":"Multiple epidermal growth factor-like domains protein 11; May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements; Belongs to the MEGF family."},{"id":"ENSMUSP00000091352","abundance":1.32,"rank":9957,"name":"Lman1l","annotation":"Protein ERGIC-53-like."},{"id":"ENSMUSP00000151504","abundance":1.32,"rank":9958,"name":"Pomc","annotation":"Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate."},{"id":"ENSMUSP00000031020","abundance":1.32,"rank":9959,"name":"4930548H24Rik","annotation":"RIKEN cDNA 4930548H24 gene."},{"id":"ENSMUSP00000157706","abundance":1.32,"rank":9960,"name":"Prelid2","annotation":"PRELI domain-containing protein 2."},{"id":"ENSMUSP00000086321","abundance":1.32,"rank":9961,"name":"Gramd4","annotation":"GRAM domain-containing protein 4; Plays a role as a mediator of E2F1-induced apoptosis in the absence of p53/TP53 (By similarity). Inhibits TLR9 response to nucelic acids and regulates TLR9-mediated innate immune response."},{"id":"ENSMUSP00000099446","abundance":1.32,"rank":9962,"name":"Gip","annotation":"Gastric inhibitory polypeptide; Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion; Belongs to the glucagon family."},{"id":"ENSMUSP00000062025","abundance":1.32,"rank":9963,"name":"Zrsr1","annotation":"U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1; Plays a role in splicing of the U12-type introns. Implicated also in removal of U2 introns positioned adjacent to a U12 intron."},{"id":"ENSMUSP00000144979","abundance":1.32,"rank":9964,"name":"Creb5","annotation":"Cyclic AMP-responsive element-binding protein 5; Binds to the cAMP response element and activates transcription; Belongs to the bZIP family."},{"id":"ENSMUSP00000033553","abundance":1.32,"rank":9965,"name":"Heph","annotation":"Hephaestin; May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1."},{"id":"ENSMUSP00000018985","abundance":1.32,"rank":9966,"name":"Rad51d","annotation":"DNA repair protein RAD51 homolog 4; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication fo [...] "},{"id":"ENSMUSP00000051441","abundance":1.31,"rank":9967,"name":"Agmo","annotation":"Alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids. Ether lipids are essential components of brain membranes (By similarity)."},{"id":"ENSMUSP00000145844","abundance":1.31,"rank":9968,"name":"Zfp108","annotation":"Zinc finger protein 108."},{"id":"ENSMUSP00000048214","abundance":1.31,"rank":9969,"name":"Plekha6","annotation":"Pleckstrin homology domain-containing family A member 6."},{"id":"ENSMUSP00000132687","abundance":1.31,"rank":9970,"name":"Rsph10b","annotation":"Radial spoke head 10 homolog B (Chlamydomonas)."},{"id":"ENSMUSP00000077694","abundance":1.31,"rank":9971,"name":"Gadl1","annotation":"Acidic amino acid decarboxylase GADL1; Catalyzes the decarboxylation of L-aspartate, 3-sulfino-L- alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. The preferred substrate is L- aspartate. Does not exhibit any decarboxylation activity toward glutamate."},{"id":"ENSMUSP00000097792","abundance":1.31,"rank":9972,"name":"Dolk","annotation":"Dolichol kinase; Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors."},{"id":"ENSMUSP00000041227","abundance":1.31,"rank":9973,"name":"Mtmr12","annotation":"Myotubularin-related protein 12; Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis ; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily."},{"id":"ENSMUSP00000107856","abundance":1.31,"rank":9974,"name":"Adipor1","annotation":"Adiponectin receptor protein 1; Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin."},{"id":"ENSMUSP00000030581","abundance":1.31,"rank":9975,"name":"Azin2","annotation":"Antizyme inhibitor 2; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the t [...] "},{"id":"ENSMUSP00000059385","abundance":1.31,"rank":9976,"name":"Nipbl","annotation":"Nipped-B-like protein; Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin. Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (By similarity). Along with ZNF609, promotes cortical neur [...] "},{"id":"ENSMUSP00000148856","abundance":1.31,"rank":9977,"name":"Olfr8","annotation":"Olfactory receptor 8; Odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000033532","abundance":1.31,"rank":9978,"name":"Aff2","annotation":"AF4/FMR2 family member 2; RNA-binding protein. Might be involved in alternative splicing regulation through an interaction with G-quartet RNA structure; Belongs to the AF4 family."},{"id":"ENSMUSP00000018630","abundance":1.31,"rank":9979,"name":"Wnt9b","annotation":"Protein Wnt-9b; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal embryonic kidney development, and for normal development of the urogenital tract, including uterus and part of the oviduct and the upper vagina in females, and epididymis and vas deferens in males. Activates a signaling cascade in the metanephric mesenchyme that induces tubulogenesis. Acts upstream of WNT4 in the signaling pathways that mediate development of kidney tubules and the Muellerian ducts. Pla [...] "},{"id":"ENSMUSP00000034774","abundance":1.31,"rank":9980,"name":"Itga11","annotation":"Integrin alpha-11; Integrin alpha-11/beta-1 is a receptor for collagen. Belongs to the integrin alpha chain family."},{"id":"ENSMUSP00000106999","abundance":1.31,"rank":9981,"name":"Nuf2","annotation":"Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules."},{"id":"ENSMUSP00000125174","abundance":1.31,"rank":9982,"name":"Fgd4","annotation":"FYVE, RhoGEF and PH domain-containing protein 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates MAPK8 (By similarity). Plays a role in regulating the actin cytoskeleton and cell shape. Promotes the formation of lamellipodia."},{"id":"ENSMUSP00000071687","abundance":1.31,"rank":9983,"name":"Nptx2","annotation":"Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity)."},{"id":"ENSMUSP00000125137","abundance":1.31,"rank":9984,"name":"Rasgrp4","annotation":"RAS guanyl-releasing protein 4; Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation. Belongs to the RASGRP family."},{"id":"ENSMUSP00000032127","abundance":1.31,"rank":9985,"name":"Gkn3","annotation":"Gastrokine-3; Inhibits gastric epithelial cell proliferation."},{"id":"ENSMUSP00000066468","abundance":1.31,"rank":9986,"name":"Lce3a","annotation":"Late cornified envelope 3A."},{"id":"ENSMUSP00000130993","abundance":1.31,"rank":9987,"name":"Lce3d","annotation":"Late cornified envelope 3D."},{"id":"ENSMUSP00000044801","abundance":1.31,"rank":9988,"name":"Herc1","annotation":"HECT and RLD domain-containing E3 ubiquitin protein ligase family member 1."},{"id":"ENSMUSP00000092761","abundance":1.31,"rank":9989,"name":"Prdm13","annotation":"PR domain zinc finger protein 13; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000148915","abundance":1.31,"rank":9990,"name":"Olfr811","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000115406","abundance":1.31,"rank":9991,"name":"Adcy3","annotation":"Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet."},{"id":"ENSMUSP00000022120","abundance":1.31,"rank":9992,"name":"Acot12","annotation":"Acetyl-coenzyme A thioesterase; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A thioesterase 12/ACOT12 preferentially hydrolyzes acetyl-CoA."},{"id":"ENSMUSP00000098687","abundance":1.31,"rank":9993,"name":"Fryl","annotation":"FRY-like transcription coactivator."},{"id":"ENSMUSP00000097812","abundance":1.31,"rank":9994,"name":"Ralgds","annotation":"Ral guanine nucleotide dissociation stimulator; Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap."},{"id":"ENSMUSP00000080468","abundance":1.31,"rank":9995,"name":"Apol9a","annotation":"Apolipoprotein L 9a."},{"id":"ENSMUSP00000129154","abundance":1.31,"rank":9996,"name":"Zfp511","annotation":"Zinc finger protein 511; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000092393","abundance":1.31,"rank":9997,"name":"Ceacam11","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 11."},{"id":"ENSMUSP00000103401","abundance":1.31,"rank":9998,"name":"Tstd2","annotation":"Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2."},{"id":"ENSMUSP00000151939","abundance":1.31,"rank":9999,"name":"Nova2","annotation":"NOVA alternative-splicing regulator 2."},{"id":"ENSMUSP00000027009","abundance":1.31,"rank":10000,"name":"Casp12","annotation":"Caspase-12; Involved in the activation cascade of caspases responsible for apoptosis execution; Belongs to the peptidase C14A family."},{"id":"ENSMUSP00000074494","abundance":1.31,"rank":10001,"name":"Bbs5","annotation":"Bardet-Biedl syndrome 5 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the gua [...] "},{"id":"ENSMUSP00000024817","abundance":1.3,"rank":10002,"name":"Rnf8","annotation":"E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] "},{"id":"ENSMUSP00000000544","abundance":1.3,"rank":10003,"name":"Acvr1b","annotation":"Activin receptor type-1B; Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine  [...] "},{"id":"ENSMUSP00000157424","abundance":1.3,"rank":10004,"name":"Asah2","annotation":"Neutral ceramidase soluble form; Plasma membrane ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at neutral pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine. Together with sphingomyelinase, participates in the production of sphingosine and sphingosine-1 [...] "},{"id":"ENSMUSP00000055899","abundance":1.3,"rank":10005,"name":"Cracr2b","annotation":"EF-hand calcium-binding domain-containing protein 4A; Plays a role in store-operated Ca(2+) entry (SOCE)."},{"id":"ENSMUSP00000047083","abundance":1.3,"rank":10006,"name":"Eepd1","annotation":"Endonuclease/exonuclease/phosphatase family domain-containing protein 1."},{"id":"ENSMUSP00000107364","abundance":1.3,"rank":10007,"name":"Tmem260","annotation":"Transmembrane protein 260; Belongs to the TMEM260 family."},{"id":"ENSMUSP00000072043","abundance":1.3,"rank":10008,"name":"Sim2","annotation":"Single-minded homolog 2; Transcription factor that may be a master gene of CNS development in cooperation with Arnt. It may have pleiotropic effects in the tissues expressed during development."},{"id":"ENSMUSP00000092508","abundance":1.3,"rank":10009,"name":"Cdc42ep5","annotation":"Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42."},{"id":"ENSMUSP00000108538","abundance":1.3,"rank":10010,"name":"Nxt2","annotation":"NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export (By similarity)."},{"id":"ENSMUSP00000112662","abundance":1.3,"rank":10011,"name":"Reep1","annotation":"Receptor expression-enhancing protein 1; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling; it links ER tubules to the cytoskeleton. May also enhance the cell surface expression of odorant receptors (By similarity); Belongs to the DP1 family."},{"id":"ENSMUSP00000097619","abundance":1.3,"rank":10012,"name":"Erich2","annotation":"Glutamate-rich 2."},{"id":"ENSMUSP00000109613","abundance":1.3,"rank":10013,"name":"M1ap","annotation":"Meiosis 1 arrest protein; Required for meiosis I progression during spermatogenesis."},{"id":"ENSMUSP00000149779","abundance":1.3,"rank":10014,"name":"Olfr307","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000035180","abundance":1.3,"rank":10015,"name":"Nudt16l2","annotation":"Nudix (nucleoside diphosphate-linked moiety X)-type motif 16-like 2."},{"id":"ENSMUSP00000011445","abundance":1.3,"rank":10016,"name":"Cd209d","annotation":"CD209 antigen-like protein D; Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens."},{"id":"ENSMUSP00000146787","abundance":1.3,"rank":10017,"name":"Homer2","annotation":"Homer protein homolog 2; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing. Negatively regula [...] "},{"id":"ENSMUSP00000085030","abundance":1.3,"rank":10018,"name":"Tnip2","annotation":"TNFAIP3-interacting protein 2; Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May ac [...] "},{"id":"ENSMUSP00000003468","abundance":1.3,"rank":10019,"name":"Grik5","annotation":"Glutamate receptor ionotropic, kainate 5; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate = glutamate >> AMPA."},{"id":"ENSMUSP00000082577","abundance":1.3,"rank":10020,"name":"Klk1b3","annotation":"Kallikrein 1-related peptidase b3; 7S NGF alpha chain stabilizes the 7S complex. The beta dimer promotes neurite growth. The gamma chain is an arginine-specific protease; it may also have plasminogen activator activity, as well as mitogenic activity for chick embryo fibroblasts."},{"id":"ENSMUSP00000061877","abundance":1.3,"rank":10021,"name":"Insig1","annotation":"Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin- mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May pla [...] "},{"id":"ENSMUSP00000066311","abundance":1.3,"rank":10022,"name":"Rbm12b2","annotation":"RNA-binding protein 12B-B."},{"id":"ENSMUSP00000044603","abundance":1.3,"rank":10023,"name":"Pim3","annotation":"Serine/threonine-protein kinase pim-3; Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2) [...] "},{"id":"ENSMUSP00000137781","abundance":1.3,"rank":10024,"name":"Gm10267","annotation":"Predicted gene 10267."},{"id":"ENSMUSP00000084039","abundance":1.3,"rank":10025,"name":"Bicd1","annotation":"Protein bicaudal D homolog 1; Regulates coat complex coatomer protein I (COPI)-independent Golgi-endoplasmic reticulum transport by recruiting the dynein-dynactin motor complex; Belongs to the BicD family."},{"id":"ENSMUSP00000055806","abundance":1.3,"rank":10026,"name":"Haspin","annotation":"Serine/threonine-protein kinase haspin; Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle."},{"id":"ENSMUSP00000151147","abundance":1.3,"rank":10027,"name":"Olfr618","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000079733","abundance":1.3,"rank":10028,"name":"Fes","annotation":"Tyrosine-protein kinase Fes/Fps; Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF  [...] "},{"id":"ENSMUSP00000022641","abundance":1.3,"rank":10029,"name":"Adamdec1","annotation":"ADAM DEC1; May play an important role in the control of the immune response and during pregnancy."},{"id":"ENSMUSP00000027507","abundance":1.29,"rank":10030,"name":"Pdcd1","annotation":"Programmed cell death protein 1; Inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. Delivers inhibitory signals upon binding to ligands, such as CD274/PDCD1L1 and CD273/PDCD1LG2. Following T-cell receptor (TCR) engagement, PDCD1 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. Suppresses T-cell activation through the recruitment of PTPN11/SHP-2: following ligand-binding, PDCD1 is phosphorylated within the ITSM motif, leading to the recruitment of the protein t [...] "},{"id":"ENSMUSP00000006478","abundance":1.29,"rank":10031,"name":"Tmem147","annotation":"Transmembrane protein 147; Acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane (By similarity). Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity (By similarity)."},{"id":"ENSMUSP00000038775","abundance":1.29,"rank":10032,"name":"Ltn1","annotation":"E3 ubiquitin-protein ligase listerin; E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). Ubiquitination leads to Vcp/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). Belongs to the LTN1 family."},{"id":"ENSMUSP00000114643","abundance":1.29,"rank":10033,"name":"Ino80c","annotation":"INO80 complex subunit C; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair."},{"id":"ENSMUSP00000048376","abundance":1.29,"rank":10034,"name":"Malt1","annotation":"Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog; Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity (By similarity). MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their coope [...] "},{"id":"ENSMUSP00000042063","abundance":1.29,"rank":10035,"name":"Tekt3","annotation":"Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility; Belongs to the tektin family."},{"id":"ENSMUSP00000073462","abundance":1.29,"rank":10036,"name":"Mon2","annotation":"Protein MON2 homolog; May be required for traffic between late Golgi and early endosomes; Belongs to the MON2 family."},{"id":"ENSMUSP00000036065","abundance":1.29,"rank":10037,"name":"Reep2","annotation":"Receptor expression-enhancing protein 2; Required for endoplasmic reticulum (ER) network formation, shaping and remodeling. May enhance the cell surface expression of odorant receptors (By similarity)."},{"id":"ENSMUSP00000084041","abundance":1.29,"rank":10038,"name":"Pkd2","annotation":"Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel. Functions as a cation channel involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Functions as outward-rectifying K(+) channel, but is also permeable to Ca(2+), and to a much lesser degree also to Na(+). May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By similarity). Together with T [...] "},{"id":"ENSMUSP00000105693","abundance":1.29,"rank":10039,"name":"Gpr68","annotation":"Ovarian cancer G-protein coupled receptor 1; Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Also functions as a metastasis suppressor gene in prostate cancer; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000052096","abundance":1.29,"rank":10040,"name":"Cdr2l","annotation":"Cerebellar degeneration-related protein 2-like; Belongs to the CDR2 family."},{"id":"ENSMUSP00000131459","abundance":1.29,"rank":10041,"name":"2810459M11Rik","annotation":"Uncharacterized protein C2orf72 homolog."},{"id":"ENSMUSP00000059783","abundance":1.29,"rank":10042,"name":"Isg20l2","annotation":"Interferon-stimulated 20 kDa exonuclease-like 2; 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group."},{"id":"ENSMUSP00000065786","abundance":1.29,"rank":10043,"name":"Astn2","annotation":"Astrotactin-2; Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1. Selectively binds inositol-4,5- bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5- tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (By similarity)."},{"id":"ENSMUSP00000051638","abundance":1.29,"rank":10044,"name":"Dact2","annotation":"Dapper homolog 2; Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling."},{"id":"ENSMUSP00000030385","abundance":1.29,"rank":10045,"name":"Ppcs","annotation":"Phosphopantothenate--cysteine ligase; Catalyzes the second step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Has a preference for ATP over CTP as a cosubstrate."},{"id":"ENSMUSP00000057751","abundance":1.29,"rank":10046,"name":"Tspan31","annotation":"Tetraspanin-31."},{"id":"ENSMUSP00000067109","abundance":1.29,"rank":10047,"name":"Usp45","annotation":"Ubiquitin carboxyl-terminal hydrolase 45; May be involved in the maintenance of photoreceptor function. Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000086890","abundance":1.29,"rank":10048,"name":"Apol10b","annotation":"Apolipoprotein L 10B."},{"id":"ENSMUSP00000088074","abundance":1.29,"rank":10049,"name":"Phf21a","annotation":"PHD finger protein 21A; Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation (By similarity)."},{"id":"ENSMUSP00000027885","abundance":1.29,"rank":10050,"name":"Angptl1","annotation":"Angiopoietin-related protein 1."},{"id":"ENSMUSP00000101667","abundance":1.29,"rank":10051,"name":"Zfp941","annotation":"Zinc finger protein 941."},{"id":"ENSMUSP00000141871","abundance":1.29,"rank":10052,"name":"Slamf7","annotation":"SLAM family member 7; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Mediates natural killer (NK) cell activation through a SH2D1A-independent extracellular signal-regulated [...] "},{"id":"ENSMUSP00000080164","abundance":1.28,"rank":10053,"name":"Scnn1a","annotation":"Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. Belongs to the amilori [...] "},{"id":"ENSMUSP00000033433","abundance":1.28,"rank":10054,"name":"Rbmx2","annotation":"RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome."},{"id":"ENSMUSP00000046216","abundance":1.28,"rank":10055,"name":"Spred3","annotation":"Sprouty-related, EVH1 domain-containing protein 3; Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase."},{"id":"ENSMUSP00000027650","abundance":1.28,"rank":10056,"name":"Cd55","annotation":"Complement decay-accelerating factor, GPI-anchored; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the format [...] "},{"id":"ENSMUSP00000157331","abundance":1.28,"rank":10057,"name":"Dcpp2","annotation":"Demilune cell and parotid protein 2."},{"id":"ENSMUSP00000020109","abundance":1.28,"rank":10058,"name":"Actr6","annotation":"Actin-related protein 6; Belongs to the actin family. ARP6 subfamily."},{"id":"ENSMUSP00000100040","abundance":1.28,"rank":10059,"name":"Mob3b","annotation":"MOB kinase activator 3B; Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis."},{"id":"ENSMUSP00000133360","abundance":1.28,"rank":10060,"name":"Sra1","annotation":"Steroid receptor RNA activator 1; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N- terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis (By similarity). Belongs to the SRA1 family."},{"id":"ENSMUSP00000109754","abundance":1.28,"rank":10061,"name":"Gm5640","annotation":"Predicted gene 5640."},{"id":"ENSMUSP00000059143","abundance":1.28,"rank":10062,"name":"Borcs6","annotation":"BLOC-1-related complex subunit 6; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor."},{"id":"ENSMUSP00000031574","abundance":1.28,"rank":10063,"name":"Spdye4b","annotation":"Speedy/RINGO cell cycle regulator family, member E4B."},{"id":"ENSMUSP00000156985","abundance":1.28,"rank":10064,"name":"Dcpp3","annotation":"Demilune cell and parotid protein 3."},{"id":"ENSMUSP00000005014","abundance":1.28,"rank":10065,"name":"Hapln2","annotation":"Hyaluronan and proteoglycan link protein 2; Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid; Belongs to the HAPLN family."},{"id":"ENSMUSP00000028910","abundance":1.28,"rank":10066,"name":"Mgme1","annotation":"Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair (By similarity). Specifi [...] "},{"id":"ENSMUSP00000101887","abundance":1.28,"rank":10067,"name":"Zfp69","annotation":"Zinc finger protein 69; Putative transcription factor that appears to regulate lipid metabolism."},{"id":"ENSMUSP00000032356","abundance":1.28,"rank":10068,"name":"Plcz1","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is t [...] "},{"id":"ENSMUSP00000092410","abundance":1.28,"rank":10069,"name":"Dhx34","annotation":"Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily."},{"id":"ENSMUSP00000061734","abundance":1.28,"rank":10070,"name":"Kctd4","annotation":"BTB/POZ domain-containing protein KCTD4."},{"id":"ENSMUSP00000082194","abundance":1.28,"rank":10071,"name":"Iqcf5","annotation":"IQ domain-containing protein F5."},{"id":"ENSMUSP00000027263","abundance":1.28,"rank":10072,"name":"Stk17b","annotation":"Serine/threonine-protein kinase 17B; Acts as a positive regulator of apoptosis. Phosphorylates myosin light chains (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily."},{"id":"ENSMUSP00000028076","abundance":1.28,"rank":10073,"name":"Mllt10","annotation":"Protein AF-10; Probably involved in transcriptional regulation. Binds to cruciform DNA (By similarity). In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (By similarity)."},{"id":"ENSMUSP00000008094","abundance":1.28,"rank":10074,"name":"Abhd8","annotation":"Protein ABHD8; Belongs to the AB hydrolase superfamily."},{"id":"ENSMUSP00000037869","abundance":1.28,"rank":10075,"name":"Rasa4","annotation":"Ras GTPase-activating protein 4; Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. Isoform 2 activates the Ras pathway and promotes RANKL shedding by modulating the expression of MMP14."},{"id":"ENSMUSP00000006151","abundance":1.28,"rank":10076,"name":"Tyrp1","annotation":"5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. Belongs to the tyrosinase family."},{"id":"ENSMUSP00000110258","abundance":1.28,"rank":10077,"name":"Cd200r3","annotation":"Cell surface glycoprotein CD200 receptor 3; According to isoform 4 is a receptor for the CD200 cell surface glycoprotein. According to isoform 4 is not a receptor for the CD200/OX2 cell surface glycoprotein. Isoform 1, isoform 2 and isoform 3 are involved in the recruitment or surface expression of the TYROBP receptor. Isoform 6, isoform 7 and isoform 8 are not involved in the recruitment or surface expression of the TYROBP receptor; Belongs to the CD200R family."},{"id":"ENSMUSP00000060305","abundance":1.28,"rank":10078,"name":"A930002H24Rik","annotation":"RIKEN cDNA A930002H24 gene."},{"id":"ENSMUSP00000027800","abundance":1.28,"rank":10079,"name":"Tmem63a","annotation":"CSC1-like protein 1; Acts as an osmosensitive calcium-permeable cation channel. Mechanosensitive ion channel that converts mechanical stimuli into a flow of ion. Belongs to the CSC1 (TC 1.A.17) family."},{"id":"ENSMUSP00000064663","abundance":1.28,"rank":10080,"name":"Dcpp1","annotation":"Demilune cell and parotid protein 1."},{"id":"ENSMUSP00000036150","abundance":1.28,"rank":10081,"name":"Six4","annotation":"Homeobox protein SIX4; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a DNA sequence on these target genes and is involved in processes like cell differentiation, cell migration and cell survival. Transactivates gene expression by binding a 5'-[CAT]A[CT][CT][CTG]GA[GAT]-3' motif present in the Trex site and from a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 site of the muscle-specific genes enhancer. Acts cooperatively with EYA proteins to transactivate their target genes through interaction and nuclear translocation of EYA prot [...] "},{"id":"ENSMUSP00000038359","abundance":1.28,"rank":10082,"name":"Mgat5","annotation":"Secreted alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A; Catalyzes the addition of N-acetylglucosamine (GlcNAc) in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. Catalyzes an important step in the biosynthesis of branched, complex- type N-glycans, such as those found on EGFR, TGFR (TGF-beta receptor) and CDH2. Via its role in the biosynthesis of complex N-glycans, plays an important role in the activation of cellular signaling pathways, reorganization of the actin cytoskeleton, cell-cell adhesion and cell migration. MGAT5 [...] "},{"id":"ENSMUSP00000052469","abundance":1.28,"rank":10083,"name":"Upk1b","annotation":"Uroplakin-1b; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)."},{"id":"ENSMUSP00000067324","abundance":1.28,"rank":10084,"name":"Terb1","annotation":"Telomere repeats-binding bouquet formation protein 1; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN- TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures an [...] "},{"id":"ENSMUSP00000053871","abundance":1.28,"rank":10085,"name":"Nipa1","annotation":"Magnesium transporter NIPA1; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+); Belongs to the NIPA family."},{"id":"ENSMUSP00000095346","abundance":1.28,"rank":10086,"name":"Pgap1","annotation":"GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi (By similarity)."},{"id":"ENSMUSP00000153547","abundance":1.28,"rank":10087,"name":"Extl3","annotation":"Exostosin-like 3; Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (By similarity)."},{"id":"ENSMUSP00000051248","abundance":1.28,"rank":10088,"name":"Vcpip1","annotation":"Deubiquitinating protein VCIP135; Acts as a deubiquitinating enzyme. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains (By similarity)."},{"id":"ENSMUSP00000146052","abundance":1.28,"rank":10089,"name":"Dedd2","annotation":"DNA-binding death effector domain-containing protein 2; May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3."},{"id":"ENSMUSP00000110781","abundance":1.27,"rank":10090,"name":"Kmt2e","annotation":"Inactive histone-lysine N-methyltransferase 2E; Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription (By similarity). Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3) (By similarity). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle regulatory ne [...] "},{"id":"ENSMUSP00000062231","abundance":1.27,"rank":10091,"name":"Samd14","annotation":"Sterile alpha motif domain-containing protein 14."},{"id":"ENSMUSP00000108433","abundance":1.27,"rank":10092,"name":"Gm15128","annotation":"Predicted gene 15128."},{"id":"ENSMUSP00000040168","abundance":1.27,"rank":10093,"name":"Fbxo45","annotation":"F-box/SPRY domain-containing protein 1; Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration. Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway. Specifically recognizes TP73, promoting its ubiquitination and degradation (By similarity); Belongs to the FBXO45/Fsn family."},{"id":"ENSMUSP00000113305","abundance":1.27,"rank":10094,"name":"Dusp13","annotation":"Dual specificity protein phosphatase 13 isoform B; Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro (By similarity). Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000029950","abundance":1.27,"rank":10095,"name":"Casp8ap2","annotation":"CASP8-associated protein 2; Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation (By similarity). Required for histone gene transcription and progression through S phase (By similarity). Required for histone gene transcription and S phase progression (By similarity). Involved in TNF- alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8 [...] "},{"id":"ENSMUSP00000068053","abundance":1.27,"rank":10096,"name":"Dmp1","annotation":"Dentin matrix acidic phosphoprotein 1; May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast- specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite (By similarity)."},{"id":"ENSMUSP00000034132","abundance":1.27,"rank":10097,"name":"Orc6","annotation":"Origin recognition complex subunit 6; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity)."},{"id":"ENSMUSP00000023840","abundance":1.27,"rank":10098,"name":"Cxcl13","annotation":"C-X-C motif chemokine 13; Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B- lymphocytes to follicles in secondary lymphoid organs."},{"id":"ENSMUSP00000032146","abundance":1.27,"rank":10099,"name":"Frmd4b","annotation":"FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization."},{"id":"ENSMUSP00000149281","abundance":1.27,"rank":10100,"name":"Olfr599","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000079929","abundance":1.27,"rank":10101,"name":"Homez","annotation":"Homeobox and leucine zipper protein Homez; May function as a transcriptional regulator."},{"id":"ENSMUSP00000138255","abundance":1.27,"rank":10102,"name":"Xcr1","annotation":"Chemokine XC receptor 1; Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin (Probable)."},{"id":"ENSMUSP00000048557","abundance":1.27,"rank":10103,"name":"Lin37","annotation":"Protein lin-37 homolog."},{"id":"ENSMUSP00000025728","abundance":1.27,"rank":10104,"name":"Frmd8","annotation":"FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17- mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity)."},{"id":"ENSMUSP00000158914","abundance":1.27,"rank":10105,"name":"Chrna3","annotation":"Neuronal acetylcholine receptor subunit alpha-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane."},{"id":"ENSMUSP00000153521","abundance":1.27,"rank":10106,"name":"Ttc37","annotation":"Tetratricopeptide repeat domain 37."},{"id":"ENSMUSP00000105353","abundance":1.27,"rank":10107,"name":"Cdk5rap1","annotation":"CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity)."},{"id":"ENSMUSP00000053394","abundance":1.27,"rank":10108,"name":"S1pr2","annotation":"Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (By similarity). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (By similarity). Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity)."},{"id":"ENSMUSP00000024104","abundance":1.27,"rank":10109,"name":"Gcm1","annotation":"Chorion-specific transcription factor GCMa; Transcription factor that is necessary for placental development. Involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (By similarity)."},{"id":"ENSMUSP00000054829","abundance":1.27,"rank":10110,"name":"Henmt1","annotation":"Small RNA 2'-O-methyltransferase; Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. Belongs to the methyltransferase superfamily. HEN1 family."},{"id":"ENSMUSP00000130440","abundance":1.27,"rank":10111,"name":"Ddx11","annotation":"ATP-dependent DNA helicase DDX11; DNA-dependent ATPase and ATP-dependent DNA helicase that participates in various functions in genomic stability, including DNA replication, DNA repair and heterochromatin organization as well as in ribosomal RNA synthesis. Its double-stranded DNA helicase activity requires either a minimal 5'-single-stranded tail length of approximately 15 nt (flap substrates) or 10 nt length single-stranded gapped DNA substrates of a partial duplex DNA structure for helicase loading and translocation along DNA in a 5' to 3' direction. The helicase activity is capable  [...] "},{"id":"ENSMUSP00000039395","abundance":1.27,"rank":10112,"name":"Kirrel2","annotation":"Kin of IRRE-like protein 2; May regulate basal insulin secretion."},{"id":"ENSMUSP00000046097","abundance":1.27,"rank":10113,"name":"Adgrb1","annotation":"Adhesion G protein-coupled receptor B1; Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion. Activates the Rho pathway in a G-protein-dependent manner (By similarity). Inhibits MDM [...] "},{"id":"ENSMUSP00000045016","abundance":1.27,"rank":10114,"name":"Cog3","annotation":"Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport."},{"id":"ENSMUSP00000108871","abundance":1.27,"rank":10115,"name":"Irak1bp1","annotation":"Interleukin-1 receptor-associated kinase 1-binding protein 1; Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity."},{"id":"ENSMUSP00000048148","abundance":1.27,"rank":10116,"name":"Stac3","annotation":"SH3 and cysteine-rich domain-containing protein 3; Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membran [...] "},{"id":"ENSMUSP00000056820","abundance":1.27,"rank":10117,"name":"Gimap5","annotation":"GTPase IMAP family member 5; Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes. Inhibitor of GSK3A. May act by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of bone marrow hematopoietic stem cells, as well as of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver functio [...] "},{"id":"ENSMUSP00000055956","abundance":1.27,"rank":10118,"name":"Zfp518a","annotation":"Zinc finger protein 518A; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000029598","abundance":1.27,"rank":10119,"name":"1700006A11Rik","annotation":"RIKEN cDNA 1700006A11 gene."},{"id":"ENSMUSP00000033035","abundance":1.27,"rank":10120,"name":"Slc5a11","annotation":"Sodium/myo-inositol cotransporter 2; Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D- chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney (By similarity)."},{"id":"ENSMUSP00000042343","abundance":1.26,"rank":10121,"name":"Efhc1","annotation":"EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death. Overexpression of EFHC1 in hippocampal primary culture neurons induced apoptosis."},{"id":"ENSMUSP00000048903","abundance":1.26,"rank":10122,"name":"Fam160b1","annotation":"Protein FAM160B1."},{"id":"ENSMUSP00000152623","abundance":1.26,"rank":10123,"name":"Syt16","annotation":"Synaptotagmin-16; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent."},{"id":"ENSMUSP00000151353","abundance":1.26,"rank":10124,"name":"Thap2","annotation":"THAP domain-containing protein 2."},{"id":"ENSMUSP00000033326","abundance":1.26,"rank":10125,"name":"Wee1","annotation":"Wee1-like protein kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase wh [...] "},{"id":"ENSMUSP00000028166","abundance":1.26,"rank":10126,"name":"Nr4a2","annotation":"Nuclear receptor subfamily 4 group A member 2; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons; Belongs to the nuclear hormone receptor family. NR4 subfamily."},{"id":"ENSMUSP00000050897","abundance":1.26,"rank":10127,"name":"S1pr1","annotation":"Sphingosine 1-phosphate receptor 1; G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal emb [...] "},{"id":"ENSMUSP00000124943","abundance":1.26,"rank":10128,"name":"Ciart","annotation":"Circadian-associated transcriptional repressor; Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK- ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes.  [...] "},{"id":"ENSMUSP00000027357","abundance":1.26,"rank":10129,"name":"Rnf25","annotation":"E3 ubiquitin-protein ligase RNF25; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2. Stimulates transcription mediated by NF-kappa-B (By similarity)."},{"id":"ENSMUSP00000012847","abundance":1.26,"rank":10130,"name":"Cd209a","annotation":"CD209 antigen-like protein A; Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens."},{"id":"ENSMUSP00000018311","abundance":1.26,"rank":10131,"name":"Stard3","annotation":"StAR-related lipid transfer protein 3; Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (By similarity). Creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (By similarity). Acts as a lipid transfer protein that redirects sterol to the endosome at the expense of the cell membrane and favors membrane formation inside endosomes (By similarity). May also mediate cholesterol transport between other membra [...] "},{"id":"ENSMUSP00000003017","abundance":1.26,"rank":10132,"name":"Tbxas1","annotation":"Thromboxane-A synthase; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000138932","abundance":1.26,"rank":10133,"name":"Obox7","annotation":"Oocyte-specific homeobox 7."},{"id":"ENSMUSP00000099302","abundance":1.26,"rank":10134,"name":"Tbcd","annotation":"Tubulin-specific chaperone D; Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP- bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes ep [...] "},{"id":"ENSMUSP00000127678","abundance":1.26,"rank":10135,"name":"Arid3c","annotation":"AT-rich interactive domain-containing protein 3C."},{"id":"ENSMUSP00000149873","abundance":1.26,"rank":10136,"name":"Olfr1251","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000151024","abundance":1.26,"rank":10137,"name":"Olfr1253","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000086158","abundance":1.26,"rank":10138,"name":"Rtl8a","annotation":"Retrotransposon Gag like 8A."},{"id":"ENSMUSP00000086157","abundance":1.26,"rank":10139,"name":"Rtl8b","annotation":"CAAX box 1 homolog A (Human)."},{"id":"ENSMUSP00000123155","abundance":1.26,"rank":10140,"name":"Naa38","annotation":"N-alpha-acetyltransferase 38, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues; Belongs to the snRNP Sm proteins family."},{"id":"ENSMUSP00000100920","abundance":1.26,"rank":10141,"name":"Kitl","annotation":"Soluble KIT ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or M [...] "},{"id":"ENSMUSP00000132696","abundance":1.26,"rank":10142,"name":"Rasl10b","annotation":"Ras-like protein family member 10B; May facilitate the release of atrial natriuretic peptide by cardiomyocytes and hence play a role in the regulation of arterial pressure; Belongs to the small GTPase superfamily. Ras family."},{"id":"ENSMUSP00000045888","abundance":1.26,"rank":10143,"name":"Abt1","annotation":"Activator of basal transcription 1; Could be a novel TATA-binding protein (TBP) which can function as a basal transcription activator. Can act as a regulator of basal transcription for class II genes; Belongs to the ESF2/ABP1 family."},{"id":"ENSMUSP00000133107","abundance":1.26,"rank":10144,"name":"Gm3667","annotation":"Predicted gene 3667."},{"id":"ENSMUSP00000111175","abundance":1.26,"rank":10145,"name":"Bcor","annotation":"BCL-6 corepressor; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA- binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' ( [...] "},{"id":"ENSMUSP00000119238","abundance":1.26,"rank":10146,"name":"Bbx","annotation":"HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase."},{"id":"ENSMUSP00000150228","abundance":1.26,"rank":10147,"name":"Olfr298","annotation":"Olfactory receptor Olfr298."},{"id":"ENSMUSP00000042883","abundance":1.26,"rank":10148,"name":"C1rl","annotation":"Complement C1r subcomponent-like protein; Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum."},{"id":"ENSMUSP00000037735","abundance":1.26,"rank":10149,"name":"Golga1","annotation":"Golgin subfamily A member 1; Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking."},{"id":"ENSMUSP00000059315","abundance":1.26,"rank":10150,"name":"Adam6a","annotation":"A disintegrin and metallopeptidase domain 6A."},{"id":"ENSMUSP00000077676","abundance":1.26,"rank":10151,"name":"Tcp11x2","annotation":"T-complex 11 family, X-linked 2."},{"id":"ENSMUSP00000102045","abundance":1.26,"rank":10152,"name":"Hs3st4","annotation":"Sulfotransferase; Belongs to the sulfotransferase 1 family."},{"id":"ENSMUSP00000057482","abundance":1.26,"rank":10153,"name":"Wdr47","annotation":"WD repeat-containing protein 47."},{"id":"ENSMUSP00000095915","abundance":1.26,"rank":10154,"name":"Exoc8","annotation":"Exocyst complex component 8; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane."},{"id":"ENSMUSP00000039338","abundance":1.25,"rank":10155,"name":"Tmem247","annotation":"Transmembrane protein 247."},{"id":"ENSMUSP00000149656","abundance":1.25,"rank":10156,"name":"Olfr91","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000079974","abundance":1.25,"rank":10157,"name":"Wdr91","annotation":"WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (By similarity). May play a role in meiosis."},{"id":"ENSMUSP00000039018","abundance":1.25,"rank":10158,"name":"Hmx3","annotation":"Homeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS; Belongs to the HMX homeobox family."},{"id":"ENSMUSP00000034611","abundance":1.25,"rank":10159,"name":"Phldb1","annotation":"Pleckstrin homology-like domain family B member 1."},{"id":"ENSMUSP00000034133","abundance":1.25,"rank":10160,"name":"Mylk3","annotation":"Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro. Has been proposed to be calmodulin-dependent , although MYL2 phosphorylation has also been observed in the presence or absence of calmodulin. Promotes sarcomere formation in cardiomyocytes and increases cardiomyocyte contractility. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family."},{"id":"ENSMUSP00000023132","abundance":1.25,"rank":10161,"name":"Pde1b","annotation":"Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate (By similarity)."},{"id":"ENSMUSP00000030332","abundance":1.25,"rank":10162,"name":"Gpx7","annotation":"Glutathione peroxidase 7; It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (By similarity)."},{"id":"ENSMUSP00000137360","abundance":1.25,"rank":10163,"name":"Ott","annotation":"Ovary testis transcribed."},{"id":"ENSMUSP00000137569","abundance":1.25,"rank":10164,"name":"Gm15085","annotation":"Predicted gene 15085."},{"id":"ENSMUSP00000136661","abundance":1.25,"rank":10165,"name":"Gm15093","annotation":"Predicted gene 15093."},{"id":"ENSMUSP00000082895","abundance":1.25,"rank":10166,"name":"Wdr35","annotation":"WD repeat-containing protein 35; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking. May promote CASP3 activation and TNF-stimulated apoptosis (By similarity)."},{"id":"ENSMUSP00000068629","abundance":1.25,"rank":10167,"name":"Ccdc88c","annotation":"Protein Daple; Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G-protein complex, triggering non-canonical Wnt responses such  [...] "},{"id":"ENSMUSP00000037616","abundance":1.25,"rank":10168,"name":"Lrfn3","annotation":"Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons."},{"id":"ENSMUSP00000134504","abundance":1.25,"rank":10169,"name":"Klrb1c","annotation":"Killer cell lectin-like receptor subfamily B member 1C; Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production."},{"id":"ENSMUSP00000046371","abundance":1.25,"rank":10170,"name":"Gde1","annotation":"Glycerophosphodiester phosphodiesterase 1; Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity)."},{"id":"ENSMUSP00000037358","abundance":1.25,"rank":10171,"name":"Rpgr","annotation":"X-linked retinitis pigmentosa GTPase regulator; Could be a guanine-nucleotide releasing factor (By similarity). Plays a role in ciliogenesis (By similarity). Probably regulates cilia formation by regulating actin stress filaments and cell contractility (By similarity). May be involved in microtubule organization and regulation of transport in primary cilia (By similarity). Plays an important role in photoreceptor integrity. Isoform 5 may play a critical role in spermatogenesis and in intraflagellar transport processes."},{"id":"ENSMUSP00000129675","abundance":1.25,"rank":10172,"name":"Prc1","annotation":"Protein regulator of cytokinesis 1; Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Belongs to the MAP65/ASE1  [...] "},{"id":"ENSMUSP00000046612","abundance":1.25,"rank":10173,"name":"Cchcr1","annotation":"Coiled-coil alpha-helical rod protein 1; May be a regulator of keratinocyte proliferation or differentiation."},{"id":"ENSMUSP00000062637","abundance":1.25,"rank":10174,"name":"C2cd3","annotation":"C2 domain-containing protein 3; Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3."},{"id":"ENSMUSP00000082500","abundance":1.25,"rank":10175,"name":"Brms1l","annotation":"Breast cancer metastasis-suppressor 1-like protein; Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth (By similarity); Belongs to the BRMS1 family."},{"id":"ENSMUSP00000149305","abundance":1.25,"rank":10176,"name":"Olfr698","annotation":"Olfactory receptor Olfr698."},{"id":"ENSMUSP00000025319","abundance":1.25,"rank":10177,"name":"Rpp21","annotation":"Ribonuclease P protein subunit p21; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 4 family."},{"id":"ENSMUSP00000047783","abundance":1.25,"rank":10178,"name":"Dnali1","annotation":"Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility; Belongs to the inner dynein arm light chain family."},{"id":"ENSMUSP00000108423","abundance":1.25,"rank":10179,"name":"Gm15080","annotation":"Predicted gene 15080."},{"id":"ENSMUSP00000042070","abundance":1.25,"rank":10180,"name":"Rab3gap1","annotation":"Rab3 GTPase-activating protein catalytic subunit; Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity)."},{"id":"ENSMUSP00000105473","abundance":1.25,"rank":10181,"name":"Rbck1","annotation":"RanBP-type and C3HC4-type zinc finger-containing protein 1; E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammat [...] "},{"id":"ENSMUSP00000022531","abundance":1.25,"rank":10182,"name":"Lats2","annotation":"Serine/threonine-protein kinase LATS2; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus  [...] "},{"id":"ENSMUSP00000157194","abundance":1.25,"rank":10183,"name":"Osbpl7","annotation":"Oxysterol-binding protein; Belongs to the OSBP family."},{"id":"ENSMUSP00000113088","abundance":1.25,"rank":10184,"name":"Iffo1","annotation":"Intermediate filament family orphan 1."},{"id":"ENSMUSP00000040048","abundance":1.25,"rank":10185,"name":"Acer2","annotation":"Alkaline ceramidase 2; Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (By similarity). Saturated long-chain ceramides and unsaturated very long- [...] "},{"id":"ENSMUSP00000038351","abundance":1.25,"rank":10186,"name":"Foxj1","annotation":"Forkhead box protein J1; Transcription factor specifically required for the formation of motile cilia. Acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. Binds the DNA consensus sequences 5'- HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). Activates the transcription of a variety of ciliary proteins in the developing brain and lung."},{"id":"ENSMUSP00000108416","abundance":1.25,"rank":10187,"name":"Gm15107","annotation":"Predicted gene 15107."},{"id":"ENSMUSP00000082458","abundance":1.24,"rank":10188,"name":"Ccpg1","annotation":"Cell cycle progression protein 1; Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation. Belongs to the CCPG1 family."},{"id":"ENSMUSP00000107765","abundance":1.24,"rank":10189,"name":"Msl3","annotation":"Male-specific lethal 3 homolog; Has a role in chromatin remodeling and transcriptional regulation. Has a role in X inactivation. Component of the MSL complex which is responsible for the majority of histone H4 acetylation at 'Lys-16' which is implicated in the formation of higher-order chromatin structure. Specifically recognizes histone H4 monomethylated at 'Lys- 20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex."},{"id":"ENSMUSP00000080512","abundance":1.24,"rank":10190,"name":"Bbof1","annotation":"Basal body-orientation factor 1; Basal body protein required in multiciliate cells to align and maintain cilia orientation in response to flow. May act by mediating a maturation step that stabilizes and aligns cilia orientation. Not required to respond to planar cell polarity (PCP) or flow-based orientation cues (By similarity); Belongs to the BBOF1 family."},{"id":"ENSMUSP00000029419","abundance":1.24,"rank":10191,"name":"Veph1","annotation":"Ventricular zone-expressed PH domain-containing protein 1; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling; Belongs to the MELT/VEPH family."},{"id":"ENSMUSP00000023104","abundance":1.24,"rank":10192,"name":"Rpap3","annotation":"RNA polymerase II-associated protein 3; Forms an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, suggesting that it is required to connect RNA polymerase II to regulators of protein complex formation. Belongs to the RPAP3 family."},{"id":"ENSMUSP00000051921","abundance":1.24,"rank":10193,"name":"Bst2","annotation":"Bone marrow stromal antigen 2; IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: h [...] "},{"id":"ENSMUSP00000112410","abundance":1.24,"rank":10194,"name":"Disc1","annotation":"Disrupted in schizophrenia 1 homolog; Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt- mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, includ [...] "},{"id":"ENSMUSP00000029546","abundance":1.24,"rank":10195,"name":"Jtb","annotation":"Protein JTB; Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity (By similarity). Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane  [...] "},{"id":"ENSMUSP00000032622","abundance":1.24,"rank":10196,"name":"Zfp773","annotation":"Zinc finger protein 773."},{"id":"ENSMUSP00000125295","abundance":1.24,"rank":10197,"name":"Zfp677","annotation":"Zinc finger protein 677."},{"id":"ENSMUSP00000048978","abundance":1.24,"rank":10198,"name":"Ccdc88a","annotation":"Girdin; Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (By similarity). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (By similarity). Essential for cell migration (By similarity). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting E [...] "},{"id":"ENSMUSP00000071611","abundance":1.24,"rank":10199,"name":"Taar7f","annotation":"Trace amine-associated receptor 7f; Olfactory receptor activated by trace amine N- methylpiperidine. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase."},{"id":"ENSMUSP00000090326","abundance":1.24,"rank":10200,"name":"Taar7e","annotation":"Trace amine-associated receptor 7e; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000048118","abundance":1.24,"rank":10201,"name":"Ceacam2","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 2; Controls energy balance and peripheral insulin action. Involved in the regulation of feeding behavior particularly in the ventromedial nucleus of hypothalamus (VMH) regulation of food intake. Has a role in the regulation of metabolic rate and insulin sensitivity or resistance via effects on brown adipogenesis, sympathetic nervous outflow to brown adipose tissue, spontaneous activity and energy expenditure in skeletal muscle. In case of murine coronavirus (MHV) infection, does probably not serve as functional receptor for the vi [...] "},{"id":"ENSMUSP00000003313","abundance":1.24,"rank":10202,"name":"Grk5","annotation":"G protein-coupled receptor kinase 5; Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-inte [...] "},{"id":"ENSMUSP00000026445","abundance":1.24,"rank":10203,"name":"Fscn2","annotation":"Fascin-2; Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundless in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links."},{"id":"ENSMUSP00000126916","abundance":1.24,"rank":10204,"name":"Abhd14a","annotation":"Protein ABHD14A; Possible role in granule neuron development. Belongs to the AB hydrolase superfamily. ABHD14 family."},{"id":"ENSMUSP00000022226","abundance":1.24,"rank":10205,"name":"Ppwd1","annotation":"Peptidylprolyl isomerase domain and WD repeat-containing protein 1; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be involved in pre-mRNA splicing."},{"id":"ENSMUSP00000149022","abundance":1.24,"rank":10206,"name":"Olfr703","annotation":"Olfactory receptor MOR283-7."},{"id":"ENSMUSP00000007245","abundance":1.24,"rank":10207,"name":"Vwa7","annotation":"Von Willebrand factor A domain-containing protein 7."},{"id":"ENSMUSP00000015620","abundance":1.24,"rank":10208,"name":"Prrt1","annotation":"Proline-rich transmembrane protein 1."},{"id":"ENSMUSP00000031621","abundance":1.24,"rank":10209,"name":"Ccz1","annotation":"Vacuolar fusion protein CCZ1 homolog; Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form."},{"id":"ENSMUSP00000089269","abundance":1.24,"rank":10210,"name":"Prl6a1","annotation":"Prolactin-6A1."},{"id":"ENSMUSP00000023610","abundance":1.24,"rank":10211,"name":"Adamts1","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 1; Cleaves aggrecan, a cartilage proteoglycan, at the '1691- Glu-|-Leu-1692' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity (By similarity). Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture (By similarity)."},{"id":"ENSMUSP00000034074","abundance":1.24,"rank":10212,"name":"N4bp1","annotation":"NEDD4-binding protein 1; Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates. Belongs to the N4BP1 family."},{"id":"ENSMUSP00000044376","abundance":1.24,"rank":10213,"name":"Pacrg","annotation":"Parkin coregulated gene protein homolog; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (By similarity)."},{"id":"ENSMUSP00000024778","abundance":1.24,"rank":10214,"name":"Med20","annotation":"Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000000573","abundance":1.23,"rank":10215,"name":"Ovgp1","annotation":"Oviduct-specific glycoprotein; Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development."},{"id":"ENSMUSP00000028368","abundance":1.23,"rank":10216,"name":"Wdsub1","annotation":"WD repeat, SAM and U-box domain-containing protein 1."},{"id":"ENSMUSP00000126080","abundance":1.23,"rank":10217,"name":"Tusc3","annotation":"Tumor suppressor candidate 3; Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with MAGT1. In its oxidized form proposed to form transient mixed disulfide [...] "},{"id":"ENSMUSP00000086041","abundance":1.23,"rank":10218,"name":"Vxn","annotation":"Vexin; Required for neurogenesis in the neural plate and retina. Strongly cooperates with neural bHLH factors to promote neurogenesis ; Belongs to the vexin family."},{"id":"ENSMUSP00000110911","abundance":1.23,"rank":10219,"name":"Zcchc12","annotation":"Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic- neuron-specific gene expression."},{"id":"ENSMUSP00000048426","abundance":1.23,"rank":10220,"name":"Tbc1d13","annotation":"TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes."},{"id":"ENSMUSP00000078454","abundance":1.23,"rank":10221,"name":"Sez6l","annotation":"Seizure 6-like protein; Candidate tumor suppressor gene. May contribute to specialized endoplasmic reticulum functions in neurons."},{"id":"ENSMUSP00000072662","abundance":1.23,"rank":10222,"name":"Carmil1","annotation":"F-actin-uncapping protein LRRC16A; Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization, however, seems unable to nucleate filaments. Plays a role in lamellipodial protrusion formations and cell migration ; Belongs to the CARMIL family."},{"id":"ENSMUSP00000000095","abundance":1.23,"rank":10223,"name":"Tbx2","annotation":"T-box transcription factor TBX2; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation (By similarity)."},{"id":"ENSMUSP00000031093","abundance":1.23,"rank":10224,"name":"Cckar","annotation":"Cholecystokinin receptor type A; Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity)."},{"id":"ENSMUSP00000064241","abundance":1.23,"rank":10225,"name":"Cd48","annotation":"CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation."},{"id":"ENSMUSP00000104411","abundance":1.23,"rank":10226,"name":"Wnt9a","annotation":"Protein Wnt-9a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity."},{"id":"ENSMUSP00000106988","abundance":1.23,"rank":10227,"name":"Nr1h3","annotation":"Oxysterols receptor LXR-alpha; Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand- binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ub [...] "},{"id":"ENSMUSP00000131540","abundance":1.23,"rank":10228,"name":"Timd2","annotation":"T-cell immunoglobulin and mucin domain-containing protein 2; Probable receptor for SEMA4A involved in the regulation of T- cell function. The interaction with SEMA4A enhances T-cell activation. Belongs to the immunoglobulin superfamily. TIM family."},{"id":"ENSMUSP00000027528","abundance":1.23,"rank":10229,"name":"Mlph","annotation":"Melanophilin; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A."},{"id":"ENSMUSP00000148286","abundance":1.23,"rank":10230,"name":"Tmem269","annotation":"Transmembrane protein 269."},{"id":"ENSMUSP00000020927","abundance":1.23,"rank":10231,"name":"Hs1bp3","annotation":"HCLS1-binding protein 3; May be a modulator of IL-2 signaling."},{"id":"ENSMUSP00000135479","abundance":1.23,"rank":10232,"name":"Evi5l","annotation":"Ecotropic viral integration site 5-like."},{"id":"ENSMUSP00000108138","abundance":1.23,"rank":10233,"name":"Chfr","annotation":"E3 ubiquitin-protein ligase CHFR; E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys- 48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURK [...] "},{"id":"ENSMUSP00000148481","abundance":1.23,"rank":10234,"name":"Ces5a","annotation":"Carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs; Belongs to the type-B carboxylesterase/lipase family."},{"id":"ENSMUSP00000106743","abundance":1.23,"rank":10235,"name":"Ccdc73","annotation":"Coiled-coil domain-containing protein 73."},{"id":"ENSMUSP00000044276","abundance":1.23,"rank":10236,"name":"Sh3pxd2b","annotation":"SH3 and PX domain-containing protein 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation. Belongs to the SH3PXD2 family."},{"id":"ENSMUSP00000030033","abundance":1.23,"rank":10237,"name":"Cavin4","annotation":"Caveolae-associated protein 4; Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes. Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway. Belongs to the CAVIN family."},{"id":"ENSMUSP00000026169","abundance":1.23,"rank":10238,"name":"Ogfod3","annotation":"2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3."},{"id":"ENSMUSP00000108464","abundance":1.23,"rank":10239,"name":"Gin1","annotation":"Gypsy retrotransposon integrase-like protein 1."},{"id":"ENSMUSP00000123803","abundance":1.23,"rank":10240,"name":"2010300C02Rik","annotation":"RIKEN cDNA 2010300C02 gene."},{"id":"ENSMUSP00000031787","abundance":1.23,"rank":10241,"name":"Evx1","annotation":"Homeobox even-skipped homolog protein 1; May play a role in the specification of neuronal cell types. May play a role in the dorsoventral specification of mesodermal cell fate."},{"id":"ENSMUSP00000034487","abundance":1.23,"rank":10242,"name":"Mmp20","annotation":"Matrix metalloproteinase-20; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site."},{"id":"ENSMUSP00000150009","abundance":1.23,"rank":10243,"name":"Olfr27","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000066561","abundance":1.23,"rank":10244,"name":"Ppm1h","annotation":"Protein phosphatase 1H; Dephosphorylates CDKN1B at 'Thr-187', thus removing a signal for proteasomal degradation."},{"id":"ENSMUSP00000127329","abundance":1.23,"rank":10245,"name":"Vldlr","annotation":"Very low-density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation."},{"id":"ENSMUSP00000032997","abundance":1.23,"rank":10246,"name":"Lat","annotation":"Linker for activation of T-cells family member 1; Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeleta [...] "},{"id":"ENSMUSP00000118666","abundance":1.23,"rank":10247,"name":"Gm14419","annotation":"Predicted gene 14419."},{"id":"ENSMUSP00000104677","abundance":1.23,"rank":10248,"name":"Gm2004","annotation":"Predicted gene 14419."},{"id":"ENSMUSP00000073875","abundance":1.23,"rank":10249,"name":"Calcrl","annotation":"Calcitonin gene-related peptide type 1 receptor; Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity)."},{"id":"ENSMUSP00000006071","abundance":1.22,"rank":10250,"name":"Otx1","annotation":"Homeobox protein OTX1; Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC- 3'; Belongs to the paired homeobox family. Bicoid subfamily."},{"id":"ENSMUSP00000157906","abundance":1.22,"rank":10251,"name":"Gm5244","annotation":"Predicted pseudogene 5244; Belongs to the eukaryotic ribosomal protein P1/P2 family."},{"id":"ENSMUSP00000137670","abundance":1.22,"rank":10252,"name":"Ksr2","annotation":"Kinase suppressor of Ras 2; Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2- mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK [...] "},{"id":"ENSMUSP00000134849","abundance":1.22,"rank":10253,"name":"Zeb2","annotation":"Zinc finger E-box-binding homeobox 2; Transcriptional inhibitor that binds to DNA sequence 5'- CACCT-3' in different promoters. Represses transcription of E-cadherin; Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family."},{"id":"ENSMUSP00000141485","abundance":1.22,"rank":10254,"name":"Olah","annotation":"S-acyl fatty acid synthase thioesterase, medium chain; Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16); Belongs to the thioesterase family."},{"id":"ENSMUSP00000025520","abundance":1.22,"rank":10255,"name":"Slc6a7","annotation":"Sodium-dependent proline transporter; Terminates the action of proline by its high affinity sodium- dependent reuptake into presynaptic terminals; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A7 subfamily."},{"id":"ENSMUSP00000074199","abundance":1.22,"rank":10256,"name":"Xlr3a","annotation":"X-linked lymphocyte-regulated protein 3A."},{"id":"ENSMUSP00000101834","abundance":1.22,"rank":10257,"name":"Cep131","annotation":"Centrosomal protein of 131 kDa; Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation. In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation. In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner [...] "},{"id":"ENSMUSP00000085806","abundance":1.22,"rank":10258,"name":"Gm14685","annotation":"Predicted gene 14685."},{"id":"ENSMUSP00000079200","abundance":1.22,"rank":10259,"name":"DXBay18","annotation":"Predicted gene, OTTMUSG00000017677."},{"id":"ENSMUSP00000113778","abundance":1.22,"rank":10260,"name":"Rapgef2","annotation":"Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...] "},{"id":"ENSMUSP00000103317","abundance":1.22,"rank":10261,"name":"Fhdc1","annotation":"FH2 domain-containing protein 1; Microtubule-associated formin which regulates both actin and microtubule dynamics. Induces microtubule acetylation and stabilization and actin stress fiber formation. Regulates Golgi ribbon formation. Required for normal cilia assembly. Early in cilia assembly, may assist in the maturation and positioning of the centrosome/basal body, and once cilia assembly has initiated, may also promote cilia elongation by inhibiting disassembly."},{"id":"ENSMUSP00000021262","abundance":1.22,"rank":10262,"name":"Alox8","annotation":"Arachidonate 8S-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Catalyzes the peroxidation of arachidonate and linoleate into (8S)- HPETE and (9S)-HPODE respectively. From arachidonate mainly produces (8S)-HPETE and in addition, minor products derived from (8S)-HPETE itself that may include leukotriene A4 and 8,15-diHPETE. With arachidonate as substrate, has no detectable 15S-lipoxygenase activity and only displays a 8S-lipoxygenase a [...] "},{"id":"ENSMUSP00000061264","abundance":1.22,"rank":10263,"name":"D17H6S53E","annotation":"Uncharacterized protein C6orf47 homolog."},{"id":"ENSMUSP00000021681","abundance":1.22,"rank":10264,"name":"Vash1","annotation":"Tubulinyl-Tyr carboxypeptidase 1; Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (By similarity); Belongs to the transglutaminase-like superfamily. Vasohibin family."},{"id":"ENSMUSP00000079631","abundance":1.22,"rank":10265,"name":"Rnf169","annotation":"E3 ubiquitin-protein ligase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair."},{"id":"ENSMUSP00000020999","abundance":1.22,"rank":10266,"name":"Kif3c","annotation":"Kinesin-like protein KIF3C; Microtubule-based anterograde translocator for membranous organelles."},{"id":"ENSMUSP00000001326","abundance":1.22,"rank":10267,"name":"Sp1","annotation":"Transcription factor Sp1; Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA da [...] "},{"id":"ENSMUSP00000028533","abundance":1.22,"rank":10268,"name":"Fshb","annotation":"Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs ; Belongs to the glycoprotein hormones subunit beta family."},{"id":"ENSMUSP00000004076","abundance":1.22,"rank":10269,"name":"Grm3","annotation":"Metabotropic glutamate receptor 3; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity."},{"id":"ENSMUSP00000029848","abundance":1.22,"rank":10270,"name":"Col24a1","annotation":"Collagen alpha-1(XXIV) chain; Involved in osteoblast differentiation. Belongs to the fibrillar collagen family."},{"id":"ENSMUSP00000112792","abundance":1.22,"rank":10271,"name":"Synpo2l","annotation":"Synaptopodin 2-like protein; Actin-associated protein that may play a role in modulating actin-based shape; Belongs to the synaptopodin family."},{"id":"ENSMUSP00000042186","abundance":1.22,"rank":10272,"name":"Abcc4","annotation":"ATP-binding cassette, sub-family C (CFTR/MRP), member 4."},{"id":"ENSMUSP00000064667","abundance":1.22,"rank":10273,"name":"Slc39a6","annotation":"Zinc transporter ZIP6; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family."},{"id":"ENSMUSP00000052210","abundance":1.22,"rank":10274,"name":"Bcl2l15","annotation":"Bcl-2-like protein 15."},{"id":"ENSMUSP00000001536","abundance":1.22,"rank":10275,"name":"Nkx2-1","annotation":"Homeobox protein Nkx-2.1; Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptio [...] "},{"id":"ENSMUSP00000032185","abundance":1.22,"rank":10276,"name":"Slc6a6","annotation":"Sodium- and chloride-dependent taurine transporter; Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake."},{"id":"ENSMUSP00000078757","abundance":1.22,"rank":10277,"name":"Ntrk2","annotation":"BDNF/NT-3 growth factors receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, [...] "},{"id":"ENSMUSP00000049983","abundance":1.22,"rank":10278,"name":"Zbtb33","annotation":"Transcriptional regulator Kaiso; Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). May recruit the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Contributes to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the re [...] "},{"id":"ENSMUSP00000144866","abundance":1.22,"rank":10279,"name":"Wdr19","annotation":"WD repeat-containing protein 19; As component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs), it is involved in cilia function and/or assembly (Probable). Essential for functional IFT-A assembly and ciliary entry of GPCRs (By similarity). Associates with the BBSome complex to mediate ciliary transport."},{"id":"ENSMUSP00000081455","abundance":1.22,"rank":10280,"name":"Mob2","annotation":"MOB kinase activator 2; Stimulates the autophosphorylation and kinase activity of STK38 and STK38L."},{"id":"ENSMUSP00000109751","abundance":1.22,"rank":10281,"name":"Gm5936","annotation":"Predicted gene 5936."},{"id":"ENSMUSP00000061597","abundance":1.22,"rank":10282,"name":"Lmod1","annotation":"Leiomodin-1; Mediates nucleation of actin filaments."},{"id":"ENSMUSP00000109602","abundance":1.22,"rank":10283,"name":"Mageb4","annotation":"Melanoma-associated antigen B4."},{"id":"ENSMUSP00000094326","abundance":1.22,"rank":10284,"name":"Map3k2","annotation":"Mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics (By similarity)."},{"id":"ENSMUSP00000072729","abundance":1.21,"rank":10285,"name":"Vps41","annotation":"Vacuolar protein sorting-associated protein 41 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal me [...] "},{"id":"ENSMUSP00000113235","abundance":1.21,"rank":10286,"name":"Fam160a1","annotation":"Protein FAM160A1; Belongs to the UPF0518 family."},{"id":"ENSMUSP00000072871","abundance":1.21,"rank":10287,"name":"Ncapd3","annotation":"Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase- mediated strand exchanges toward chromatid decatenation. Specifically required for decatenation of centromeric ultrafine DNA bridges during anaphase. Early [...] "},{"id":"ENSMUSP00000147467","abundance":1.21,"rank":10288,"name":"Fbxo25","annotation":"F-box only protein 25; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT)."},{"id":"ENSMUSP00000040481","abundance":1.21,"rank":10289,"name":"Upk2","annotation":"Uroplakin-2; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM."},{"id":"ENSMUSP00000040210","abundance":1.21,"rank":10290,"name":"Slc44a3","annotation":"Choline transporter-like protein 3."},{"id":"ENSMUSP00000149130","abundance":1.21,"rank":10291,"name":"Mbd3l2","annotation":"Methyl-CpG-binding domain protein 3-like 2."},{"id":"ENSMUSP00000147135","abundance":1.21,"rank":10292,"name":"Rapgef6","annotation":"Rap guanine nucleotide exchange factor (GEF) 6."},{"id":"ENSMUSP00000036951","abundance":1.21,"rank":10293,"name":"H1f8","annotation":"Histone H1oo; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling."},{"id":"ENSMUSP00000057065","abundance":1.21,"rank":10294,"name":"Pram1","annotation":"PML-RARA-regulated adapter molecule 1; May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P."},{"id":"ENSMUSP00000090710","abundance":1.21,"rank":10295,"name":"Slc47a2","annotation":"Multidrug and toxin extrusion protein 2; Solute transporter for tetraethylammonium (TEA), cimetidine, choline, procainamide, cimetidine, quinidine, guanidine, N- methylnicotinamide (NMN). Responsible for the secretion of cationic drugs across the brush border membranes; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family."},{"id":"ENSMUSP00000033331","abundance":1.21,"rank":10296,"name":"Nrip3","annotation":"Nuclear receptor-interacting protein 3."},{"id":"ENSMUSP00000110412","abundance":1.21,"rank":10297,"name":"Slc26a8","annotation":"Testis anion transporter 1; Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes  [...] "},{"id":"ENSMUSP00000031097","abundance":1.21,"rank":10298,"name":"Tada2b","annotation":"Transcriptional adapter."},{"id":"ENSMUSP00000128223","abundance":1.21,"rank":10299,"name":"Slc37a1","annotation":"Glucose-6-phosphate exchanger SLC37A1; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels."},{"id":"ENSMUSP00000050729","abundance":1.21,"rank":10300,"name":"Tmem18","annotation":"Transmembrane protein 18; Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC) (By similarity)."},{"id":"ENSMUSP00000049826","abundance":1.21,"rank":10301,"name":"1700012B09Rik","annotation":"Uncharacterized protein C11orf97 homolog."},{"id":"ENSMUSP00000150159","abundance":1.21,"rank":10302,"name":"Olfr1109","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000142299","abundance":1.21,"rank":10303,"name":"Camsap2","annotation":"Calmodulin-regulated spectrin-associated protein 2; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (By similarity). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (By similarity). In addition, it also red [...] "},{"id":"ENSMUSP00000020000","abundance":1.21,"rank":10304,"name":"Hebp2","annotation":"Heme-binding protein 2; Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions (By similarity). May have low affinity for heme ; Belongs to the HEBP family."},{"id":"ENSMUSP00000080820","abundance":1.21,"rank":10305,"name":"Zc3h12b","annotation":"Zinc finger CCCH-type-containing 12B."},{"id":"ENSMUSP00000039012","abundance":1.21,"rank":10306,"name":"Hoxa5","annotation":"Homeobox protein Hox-A5; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'."},{"id":"ENSMUSP00000091439","abundance":1.21,"rank":10307,"name":"Myo15b","annotation":"Myosin XVB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000054980","abundance":1.21,"rank":10308,"name":"Exd1","annotation":"piRNA biogenesis protein EXD1; RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 p [...] "},{"id":"ENSMUSP00000033050","abundance":1.21,"rank":10309,"name":"Lyve1","annotation":"Lymphatic vessel endothelial hyaluronic acid receptor 1; Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes."},{"id":"ENSMUSP00000040847","abundance":1.2,"rank":10310,"name":"Adrb1","annotation":"Beta-1 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling (By similarity). Involved in the regulation of sleep/wake behaviors."},{"id":"ENSMUSP00000019426","abundance":1.2,"rank":10311,"name":"Dsg4","annotation":"Desmoglein-4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes."},{"id":"ENSMUSP00000066906","abundance":1.2,"rank":10312,"name":"Rnf133","annotation":"E3 ubiquitin-protein ligase RNF133; Has E3 ubiquitin-protein ligase activity."},{"id":"ENSMUSP00000031326","abundance":1.2,"rank":10313,"name":"Cxcl3","annotation":"C-X-C motif chemokine 3; Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion."},{"id":"ENSMUSP00000036983","abundance":1.2,"rank":10314,"name":"Car14","annotation":"Carbonic anhydrase 14; Reversible hydration of carbon dioxide; Belongs to the alpha-carbonic anhydrase family."},{"id":"ENSMUSP00000031795","abundance":1.2,"rank":10315,"name":"Fkbp9","annotation":"Peptidyl-prolyl cis-trans isomerase FKBP9; PPIases accelerate the folding of proteins during protein synthesis."},{"id":"ENSMUSP00000047431","abundance":1.2,"rank":10316,"name":"Tagap","annotation":"T-cell activation Rho GTPase-activating protein; May function as a GTPase-activating protein. May play a role in transmission ratio distortion (TRD) in mouse, in which heterozygous males for t-locus transmit their t-carrying chromosome to 95% or more of their offspring."},{"id":"ENSMUSP00000092809","abundance":1.2,"rank":10317,"name":"Gm10309","annotation":"Predicted gene 10309."},{"id":"ENSMUSP00000140285","abundance":1.2,"rank":10318,"name":"Zfp709","annotation":"Zinc finger protein 709."},{"id":"ENSMUSP00000048454","abundance":1.2,"rank":10319,"name":"Armh3","annotation":"Armadillo-like helical domain-containing protein 3; Involved in GBF1 recruitment, Golgi maintenance and protein secretion; Belongs to the ARMH3 family."},{"id":"ENSMUSP00000038149","abundance":1.2,"rank":10320,"name":"Hpn","annotation":"Serine protease hepsin non-catalytic chain; Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL. Plays a role in cell growth and maintenance of cell morphology. Plays a role in the proteolytic processing of ACE2 (By similarity). Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization."},{"id":"ENSMUSP00000032248","abundance":1.2,"rank":10321,"name":"Clec4a2","annotation":"C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation."},{"id":"ENSMUSP00000037821","abundance":1.2,"rank":10322,"name":"Ttyh2","annotation":"Protein tweety homolog 2; Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. May be involved in cell proliferation and cell aggregation (By similarity)."},{"id":"ENSMUSP00000105312","abundance":1.2,"rank":10323,"name":"Triobp","annotation":"TRIO and F-actin-binding protein; May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F- actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover."},{"id":"ENSMUSP00000126141","abundance":1.2,"rank":10324,"name":"Ccnd3","annotation":"G1/S-specific cyclin-D3; Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] "},{"id":"ENSMUSP00000084701","abundance":1.2,"rank":10325,"name":"Bmpr2","annotation":"Bone morphogenetic protein receptor type-2; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. Mediates induction of adipogenesis by GDF6."},{"id":"ENSMUSP00000128126","abundance":1.2,"rank":10326,"name":"Pick1","annotation":"PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] "},{"id":"ENSMUSP00000026315","abundance":1.2,"rank":10327,"name":"Dnase1l3","annotation":"Deoxyribonuclease gamma; Has DNA hydrolytic activity. Is capable of both single- and double-stranded DNA cleavage, producing DNA fragments with 3'-OH ends (By similarity). Can cleave chromatin to nucleosomal units and cleaves nucleosomal and liposome-coated DNA. Acts in internucleosomal DNA fragmentation (INDF) during apoptosis and necrosis. The role in apoptosis includes myogenic and neuronal differentiation, and BCR-mediated clonal deletion of self- reactive B cells. Is active on chromatin in apoptotic cell-derived membrane-coated microparticles and thus suppresses anti-DNA autoimmun [...] "},{"id":"ENSMUSP00000039010","abundance":1.2,"rank":10328,"name":"Wdr55","annotation":"WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis."},{"id":"ENSMUSP00000032073","abundance":1.2,"rank":10329,"name":"Nat8","annotation":"N-acetyltransferase 8; Acetylates the free alpha-amino group of cysteine S- conjugates to form mercapturic acids. This is the final step in a major route for detoxification of a wide variety of reactive electrophiles which starts with their incorporation into glutathione S-conjugates. The glutathione S-conjugates are then further processed into cysteine S-conjugates and finally mercapturic acids which are water soluble and can be readily excreted in urine or bile. Alternatively, may have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6- acetylation of various protein [...] "},{"id":"ENSMUSP00000106087","abundance":1.2,"rank":10330,"name":"Myo10","annotation":"Unconventional myosin-X; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments (By similarity). Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. In hippo [...] "},{"id":"ENSMUSP00000091308","abundance":1.2,"rank":10331,"name":"Slc35g2","annotation":"Solute carrier family 35 member G2."},{"id":"ENSMUSP00000034244","abundance":1.2,"rank":10332,"name":"Tmem38a","annotation":"Trimeric intracellular cation channel type A; Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores."},{"id":"ENSMUSP00000115813","abundance":1.2,"rank":10333,"name":"Asb8","annotation":"Ankyrin repeat and SOCS box protein 8; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family."},{"id":"ENSMUSP00000038013","abundance":1.2,"rank":10334,"name":"Osbpl10","annotation":"Oxysterol-binding protein-related protein 10; Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphat [...] "},{"id":"ENSMUSP00000032191","abundance":1.2,"rank":10335,"name":"Sumf1","annotation":"Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family."},{"id":"ENSMUSP00000073463","abundance":1.2,"rank":10336,"name":"Mrgpra6","annotation":"Mas-related G-protein coupled receptor member A6; Orphan receptor. May be a receptor for RFamide-family neuropeptides such as NPFF and NPAF, which are analgesic in vivo. May regulate nociceptor function and/or development, including the sensation or modulation of pain (By similarity)."},{"id":"ENSMUSP00000100050","abundance":1.2,"rank":10337,"name":"Mcm10","annotation":"Protein MCM10 homolog; Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. Key effector of the RBBP6 and ZBTB38-mediated regulation of DNA-replication and common fragile sites stability; acts as a direct target of transcriptional repression by ZBTB38 (By similarity)."},{"id":"ENSMUSP00000051782","abundance":1.2,"rank":10338,"name":"Ttc34","annotation":"Tetratricopeptide repeat protein 34."},{"id":"ENSMUSP00000037128","abundance":1.2,"rank":10339,"name":"Qsox2","annotation":"Sulfhydryl oxidase 2; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins (By similarity)."},{"id":"ENSMUSP00000065529","abundance":1.19,"rank":10340,"name":"Adam6b","annotation":"A disintegrin and metallopeptidase domain 6B."},{"id":"ENSMUSP00000026269","abundance":1.19,"rank":10341,"name":"Limd1","annotation":"LIM domain-containing protein 1; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts [...] "},{"id":"ENSMUSP00000102710","abundance":1.19,"rank":10342,"name":"Txnip","annotation":"Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and co [...] "},{"id":"ENSMUSP00000112836","abundance":1.19,"rank":10343,"name":"Creb3l3","annotation":"Processed cyclic AMP-responsive element-binding protein 3-like protein 3; Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. Binds to the cAMP response element (CRE). Activates transcription through box-B element (By similarity). Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression; Belongs to the bZIP family. ATF  [...] "},{"id":"ENSMUSP00000064761","abundance":1.19,"rank":10344,"name":"Adm2","annotation":"Adrenomedullin-2; [Adrenomedullin-2]: May play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway."},{"id":"ENSMUSP00000077296","abundance":1.19,"rank":10345,"name":"Olfr503","annotation":"Olfactory receptor Olfr503."},{"id":"ENSMUSP00000040356","abundance":1.19,"rank":10346,"name":"Hgsnat","annotation":"Heparan-alpha-glucosaminide N-acetyltransferase; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase."},{"id":"ENSMUSP00000027257","abundance":1.19,"rank":10347,"name":"Mitd1","annotation":"MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex."},{"id":"ENSMUSP00000140131","abundance":1.19,"rank":10348,"name":"Chrm3","annotation":"Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily."},{"id":"ENSMUSP00000026150","abundance":1.19,"rank":10349,"name":"Arhgap19","annotation":"Rho GTPase-activating protein 19; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state."},{"id":"ENSMUSP00000024999","abundance":1.19,"rank":10350,"name":"Tpsg1","annotation":"Tryptase gamma heavy chain; Belongs to the peptidase S1 family. Tryptase subfamily."},{"id":"ENSMUSP00000058468","abundance":1.19,"rank":10351,"name":"Zfp536","annotation":"Zinc finger protein 536; May be involved in transcriptional regulation. Recognizes and binds 2 copies of the core DNA sequence 5'-CCCCCA-3' (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000099640","abundance":1.19,"rank":10352,"name":"2810408A11Rik","annotation":"RIKEN cDNA 2810408A11 gene."},{"id":"ENSMUSP00000122066","abundance":1.19,"rank":10353,"name":"Arfrp1","annotation":"ADP-ribosylation factor-related protein 1; Trans-Golgi-associated GTPase that regulates protein sorting. Controls the targeting of ARL1 and its effector to the trans-Golgi. Required for the lipidation of chylomicrons in the intestine and required for VLDL lipidation in the liver. Belongs to the small GTPase superfamily. Arf family."},{"id":"ENSMUSP00000035237","abundance":1.19,"rank":10354,"name":"Usp4","annotation":"Ubiquitin carboxyl-terminal hydrolase 4; Deubiquitinating enzyme that removes conjugated ubiquitin from target proteins. Deubiquitinates PDPK1. Deubiquitinates TRIM21. Deubiquitinates receptor ADORA2A which increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER."},{"id":"ENSMUSP00000142872","abundance":1.19,"rank":10355,"name":"Dnase2b","annotation":"Deoxyribonuclease-2-beta; Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation."},{"id":"ENSMUSP00000054208","abundance":1.19,"rank":10356,"name":"Garem2","annotation":"GRB2-associated and regulator of MAPK protein 2; Probable adapter protein that provides a critical link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway; Belongs to the GAREM family."},{"id":"ENSMUSP00000145446","abundance":1.19,"rank":10357,"name":"Olfr1415","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000137662","abundance":1.19,"rank":10358,"name":"Foxf1","annotation":"Forkhead box protein F1; Probable transcription activator for a number of lung- specific genes."},{"id":"ENSMUSP00000052085","abundance":1.19,"rank":10359,"name":"Daam2","annotation":"Disheveled-associated activator of morphogenesis 2; Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands and upstream of beta-catenin (CTNNB1). Required for canonical Wnt signaling pathway during patterning in the dorsal spinal cord by promoting the aggregation of Disheveled (Dvl) complexes, thereby clustering and formation of Wnt receptor signalosomes and potentiating Wnt activity. During dorsal  [...] "},{"id":"ENSMUSP00000110288","abundance":1.19,"rank":10360,"name":"Cntnap2","annotation":"Contactin-associated protein-like 2; Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction (Probable)."},{"id":"ENSMUSP00000118180","abundance":1.19,"rank":10361,"name":"Mfsd14b","annotation":"Hippocampus abundant transcript-like protein 1."},{"id":"ENSMUSP00000098453","abundance":1.19,"rank":10362,"name":"Gm8281","annotation":"Predicted gene, 8281."},{"id":"ENSMUSP00000130159","abundance":1.19,"rank":10363,"name":"Gm10340","annotation":"Predicted gene 10340."},{"id":"ENSMUSP00000128655","abundance":1.19,"rank":10364,"name":"Gm3629","annotation":"Predicted gene 3629."},{"id":"ENSMUSP00000129516","abundance":1.19,"rank":10365,"name":"Gm10128","annotation":"Predicted gene 10128."},{"id":"ENSMUSP00000130116","abundance":1.19,"rank":10366,"name":"Snx14","annotation":"Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family."},{"id":"ENSMUSP00000078129","abundance":1.19,"rank":10367,"name":"AY358078","annotation":"cDNA sequence AY358078."},{"id":"ENSMUSP00000125749","abundance":1.19,"rank":10368,"name":"Trmt10a","annotation":"tRNA methyltransferase 10 homolog A; S-adenosyl-L-methionine-dependent guanine N(1)- methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs. Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family."},{"id":"ENSMUSP00000133175","abundance":1.19,"rank":10369,"name":"Klhl25","annotation":"Kelch-like protein 25; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E."},{"id":"ENSMUSP00000106301","abundance":1.19,"rank":10370,"name":"Kpna7","annotation":"Importin subunit alpha-8; Functions in nuclear protein import."},{"id":"ENSMUSP00000099848","abundance":1.19,"rank":10371,"name":"Dennd1a","annotation":"DENN domain-containing protein 1A; Guanine nucleotide exchange factor (GEF) regulating clathrin- mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP- bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes. Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P."},{"id":"ENSMUSP00000061221","abundance":1.19,"rank":10372,"name":"Mindy4","annotation":"Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins."},{"id":"ENSMUSP00000094420","abundance":1.19,"rank":10373,"name":"Adam25","annotation":"Disintegrin and metalloproteinase domain-containing protein 25; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization."},{"id":"ENSMUSP00000043676","abundance":1.19,"rank":10374,"name":"Dicer1","annotation":"Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] "},{"id":"ENSMUSP00000051845","abundance":1.18,"rank":10375,"name":"Ino80","annotation":"Chromatin-remodeling ATPase INO80; ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule as [...] "},{"id":"ENSMUSP00000021990","abundance":1.18,"rank":10376,"name":"Ptdss1","annotation":"Phosphatidylserine synthase 1; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine."},{"id":"ENSMUSP00000108261","abundance":1.18,"rank":10377,"name":"Evi5","annotation":"Ecotropic viral integration site 5 protein; Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis (By similarity)."},{"id":"ENSMUSP00000122345","abundance":1.18,"rank":10378,"name":"Prn","annotation":"Prion protein readthrough transcript."},{"id":"ENSMUSP00000105801","abundance":1.18,"rank":10379,"name":"Prnd","annotation":"Prion-like protein doppel; Required for normal acrosome reaction and for normal male fertility. Can bind Cu(2+) (By similarity)."},{"id":"ENSMUSP00000079965","abundance":1.18,"rank":10380,"name":"Manbal","annotation":"Protein MANBAL."},{"id":"ENSMUSP00000042185","abundance":1.18,"rank":10381,"name":"Ndufa4l2","annotation":"NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2; Belongs to the complex I NDUFA4 subunit family."},{"id":"ENSMUSP00000025109","abundance":1.18,"rank":10382,"name":"Sap130","annotation":"Histone deacetylase complex subunit SAP130; Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity); Belongs to the SAP130 family."},{"id":"ENSMUSP00000109894","abundance":1.18,"rank":10383,"name":"Lingo1","annotation":"Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development."},{"id":"ENSMUSP00000149141","abundance":1.18,"rank":10384,"name":"Olfr1417","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000102152","abundance":1.18,"rank":10385,"name":"Hid1","annotation":"Protein HID1; Belongs to the hid-1 family."},{"id":"ENSMUSP00000088271","abundance":1.18,"rank":10386,"name":"Zfp385b","annotation":"Zinc finger protein 385B; May play a role in p53/TP53-mediated apoptosis."},{"id":"ENSMUSP00000088447","abundance":1.18,"rank":10387,"name":"Rusc1","annotation":"RUN and SH3 domain-containing protein 1; Putative signaling adapter which may play a role in neuronal differentiation. May be involved in regulation of NGF-dependent neurite outgrowth. Proposed to play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins. Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway."},{"id":"ENSMUSP00000019938","abundance":1.18,"rank":10388,"name":"Nr2e1","annotation":"Nuclear receptor subfamily 2 group E member 1; Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Regulates cell cycle progression in neural stem cells of rhe developing brain. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be invol [...] "},{"id":"ENSMUSP00000104167","abundance":1.18,"rank":10389,"name":"Dhx33","annotation":"ATP-dependent RNA helicase DHX33; Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation. Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (By similarity). Requi [...] "},{"id":"ENSMUSP00000082862","abundance":1.18,"rank":10390,"name":"Mark4","annotation":"MAP/microtubule affinity-regulating kinase 4; Serine/threonine-protein kinase (By similarity). Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (By similarity). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (By similarity). Required for the initiation of axoneme extension during cilium assembly (By similarity). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (By similarity). Plays a role in cell cycle progr [...] "},{"id":"ENSMUSP00000125552","abundance":1.18,"rank":10391,"name":"Hint3","annotation":"Histidine triad nucleotide-binding protein 3; Hydrolyzes phosphoramidate and acyl-adenylate substrates."},{"id":"ENSMUSP00000137541","abundance":1.18,"rank":10392,"name":"Faiml","annotation":"Fas apoptotic inhibitory molecule-like."},{"id":"ENSMUSP00000036277","abundance":1.18,"rank":10393,"name":"Ints7","annotation":"Integrator complex subunit 7; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase. May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex."},{"id":"ENSMUSP00000022716","abundance":1.18,"rank":10394,"name":"Rnf219","annotation":"ORC ubiquitin ligase 1; E3 ubiquitin ligase essential for DNA replication origin activation during S phase. Acts as a replication origin selector which selects the origins to be fired and catalyzes the multi-mono- ubiquitination of a subset of chromatin-bound ORC3 and ORC5 during S- phase."},{"id":"ENSMUSP00000112922","abundance":1.18,"rank":10395,"name":"Acp4","annotation":"Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis; Belongs to the histidine acid phosphatase family."},{"id":"ENSMUSP00000150825","abundance":1.18,"rank":10396,"name":"Olfr161","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000099316","abundance":1.18,"rank":10397,"name":"Mgat5b","annotation":"Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; Glycosyltransferase that acts on alpha-linked mannose of N- glycans and O-mannosyl glycans. Catalyzes the transfer of N- acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6- linked mannose arms in the core structure of N-glycan (By similarity). Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adh [...] "},{"id":"ENSMUSP00000145440","abundance":1.18,"rank":10398,"name":"Kcnj8","annotation":"ATP-sensitive inward rectifier potassium channel 8; This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium (By similarity). Belon [...] "},{"id":"ENSMUSP00000028911","abundance":1.18,"rank":10399,"name":"Kat14","annotation":"Cysteine-rich protein 2-binding protein; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle (By similarity)."},{"id":"ENSMUSP00000128789","abundance":1.18,"rank":10400,"name":"Kdm3a","annotation":"Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation  [...] "},{"id":"ENSMUSP00000018593","abundance":1.18,"rank":10401,"name":"Rpain","annotation":"RPA-interacting protein; Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Sumoylation mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism (By similarity)."},{"id":"ENSMUSP00000150541","abundance":1.18,"rank":10402,"name":"Inpp4b","annotation":"Type II inositol 3,4-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (By similarity). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity)."},{"id":"ENSMUSP00000057965","abundance":1.18,"rank":10403,"name":"Trpc6","annotation":"Short transient receptor potential channel 6; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion."},{"id":"ENSMUSP00000033711","abundance":1.18,"rank":10404,"name":"Gabrq","annotation":"Gamma-aminobutyric acid receptor subunit theta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel."},{"id":"ENSMUSP00000006716","abundance":1.18,"rank":10405,"name":"Wnt6","annotation":"Protein Wnt-6; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters."},{"id":"ENSMUSP00000035630","abundance":1.18,"rank":10406,"name":"Gjb6","annotation":"Gap junction beta-6 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell."},{"id":"ENSMUSP00000026162","abundance":1.18,"rank":10407,"name":"Sectm1a","annotation":"Secreted and transmembrane protein 1A."},{"id":"ENSMUSP00000035148","abundance":1.18,"rank":10408,"name":"Slco2a1","annotation":"Solute carrier organic anion transporter family member 2A1; May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A; Belongs to the organo anion transporter (TC 2.A.60) family."},{"id":"ENSMUSP00000004756","abundance":1.18,"rank":10409,"name":"Wwox","annotation":"WW domain-containing oxidoreductase; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm (By similarity). May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development."},{"id":"ENSMUSP00000026073","abundance":1.18,"rank":10410,"name":"Trub1","annotation":"Probable tRNA pseudouridine synthase 1; Pseudouridine synthase that catalyzes pseudouridylation of mRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs; Belongs to the pseudouridine synthase TruB family."},{"id":"ENSMUSP00000147956","abundance":1.18,"rank":10411,"name":"Tti2","annotation":"TELO2-interacting protein 2; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs (By similarity); Belongs to the TTI2 family."},{"id":"ENSMUSP00000150150","abundance":1.18,"rank":10412,"name":"Olfr1034","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000130843","abundance":1.18,"rank":10413,"name":"Olfr1036","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000000940","abundance":1.17,"rank":10414,"name":"Nsun5","annotation":"Probable 28S rRNA (cytosine-C(5))-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of a cytosine in 28S rRNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family."},{"id":"ENSMUSP00000078985","abundance":1.17,"rank":10415,"name":"Krit1","annotation":"Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Promotes AKT phosphorylation in a NOTCH- dependent and independent manner, and inhibits ERK1/2 phosphorylation indirectly through activation of the DELTA-NOTCH cascade. Acts in concert with CDH5 to establish and maintain correct endothelial cell polarity and vascular lumen an [...] "},{"id":"ENSMUSP00000126598","abundance":1.17,"rank":10416,"name":"Arhgef12","annotation":"Rho guanine nucleotide exchange factor 12; May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13 (By similarity)."},{"id":"ENSMUSP00000136775","abundance":1.17,"rank":10417,"name":"Mro","annotation":"Protein maestro."},{"id":"ENSMUSP00000131030","abundance":1.17,"rank":10418,"name":"Sipa1l1","annotation":"Signal-induced proliferation-associated 1-like protein 1; Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis (By similarity)."},{"id":"ENSMUSP00000002740","abundance":1.17,"rank":10419,"name":"Pspn","annotation":"Persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons."},{"id":"ENSMUSP00000026218","abundance":1.17,"rank":10420,"name":"Cwf19l1","annotation":"CWF19-like protein 1."},{"id":"ENSMUSP00000130661","abundance":1.17,"rank":10421,"name":"Gm10406","annotation":"Predicted gene 10406."},{"id":"ENSMUSP00000127555","abundance":1.17,"rank":10422,"name":"Gm8237","annotation":"Predicted gene 8237."},{"id":"ENSMUSP00000130601","abundance":1.17,"rank":10423,"name":"Gm3558","annotation":"Predicted gene, ENSMUSG00000063277."},{"id":"ENSMUSP00000130084","abundance":1.17,"rank":10424,"name":"Gm2974","annotation":"Predicted gene 2974."},{"id":"ENSMUSP00000131718","abundance":1.17,"rank":10425,"name":"Gm3298","annotation":"Predicted gene 3298."},{"id":"ENSMUSP00000079498","abundance":1.17,"rank":10426,"name":"Gm4559","annotation":"ENSMUSG00000056885 protein."},{"id":"ENSMUSP00000026406","abundance":1.17,"rank":10427,"name":"Rdh5","annotation":"Retinol dehydrogenase 5; Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal (By similarity). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity). ECO:0000250|UniProtKB:Q92781, ; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000113818","abundance":1.17,"rank":10428,"name":"Pigg","annotation":"Phosphatidylinositol glycan anchor biosynthesis, class G."},{"id":"ENSMUSP00000030140","abundance":1.17,"rank":10429,"name":"Elp1","annotation":"Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in neurogenesis. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. May act as a scaffold protein that may assemble active IKK-MAP3K14 co [...] "},{"id":"ENSMUSP00000084904","abundance":1.17,"rank":10430,"name":"Plekha5","annotation":"Pleckstrin homology domain-containing, family A member 5."},{"id":"ENSMUSP00000106877","abundance":1.17,"rank":10431,"name":"Accs","annotation":"1-aminocyclopropane-1-carboxylate synthase-like protein 1; Does not catalyze the synthesis of 1-aminocyclopropane-1- carboxylate but is capable of catalyzing the deamination of L- vinylglycine; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family."},{"id":"ENSMUSP00000082971","abundance":1.17,"rank":10432,"name":"Ncoa1","annotation":"Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...] "},{"id":"ENSMUSP00000125857","abundance":1.17,"rank":10433,"name":"Cpeb2","annotation":"Cytoplasmic polyadenylation element-binding protein 2; May play a role in translational regulation of stored mRNAs in transcriptionally inactive haploid spermatids. Binds to poly(U) RNA oligomers. Required for cell cycle progression, specifically for the transition from metaphase to anaphase (By similarity)."},{"id":"ENSMUSP00000064246","abundance":1.17,"rank":10434,"name":"Chst1","annotation":"Carbohydrate sulfotransferase 1; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. P [...] "},{"id":"ENSMUSP00000130900","abundance":1.17,"rank":10435,"name":"Mms19","annotation":"MMS19 nucleotide excision repair protein homolog; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target Fe/S proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER), homologous recombination-mediated double-strand break DNA repair, DNA replication  [...] "},{"id":"ENSMUSP00000040762","abundance":1.17,"rank":10436,"name":"Cep104","annotation":"Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip."},{"id":"ENSMUSP00000030320","abundance":1.17,"rank":10437,"name":"Cc2d1b","annotation":"Coiled-coil and C2 domain-containing protein 1B; Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells; Belongs to the CC2D1 family."},{"id":"ENSMUSP00000090355","abundance":1.17,"rank":10438,"name":"Ttc25","annotation":"Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility."},{"id":"ENSMUSP00000092715","abundance":1.17,"rank":10439,"name":"Foxe1","annotation":"Forkhead box protein E1; Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression (By similarity)."},{"id":"ENSMUSP00000036369","abundance":1.17,"rank":10440,"name":"Ccdc122","annotation":"Coiled-coil domain-containing protein 122."},{"id":"ENSMUSP00000109547","abundance":1.17,"rank":10441,"name":"Pigp","annotation":"Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis; Belongs to the PIGP family."},{"id":"ENSMUSP00000020251","abundance":1.17,"rank":10442,"name":"Gnptab","annotation":"N-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment; Belongs to the stealth family."},{"id":"ENSMUSP00000093939","abundance":1.17,"rank":10443,"name":"Adcy6","annotation":"Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta- adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the [...] "},{"id":"ENSMUSP00000104211","abundance":1.17,"rank":10444,"name":"Ccdc106","annotation":"Coiled-coil domain-containing protein 106; Promotes the degradation of p53/TP53 protein and inhibits its transactivity."},{"id":"ENSMUSP00000038165","abundance":1.17,"rank":10445,"name":"Necab1","annotation":"N-terminal EF-hand calcium-binding protein 1."},{"id":"ENSMUSP00000102582","abundance":1.17,"rank":10446,"name":"Tomt","annotation":"Transmembrane O-methyltransferase homolog; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Required for auditory function. Component of the cochlear hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity ; Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-de [...] "},{"id":"ENSMUSP00000070554","abundance":1.17,"rank":10447,"name":"Usp46","annotation":"Ubiquitin carboxyl-terminal hydrolase 46; Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 (By similarity)."},{"id":"ENSMUSP00000074898","abundance":1.17,"rank":10448,"name":"Nectin2","annotation":"Nectin-2; Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein."},{"id":"ENSMUSP00000049430","abundance":1.17,"rank":10449,"name":"Zmat4","annotation":"Zinc finger matrin-type protein 4."},{"id":"ENSMUSP00000020549","abundance":1.17,"rank":10450,"name":"Gzmm","annotation":"Granzyme M (Lymphocyte Met-ase 1); Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000034265","abundance":1.17,"rank":10451,"name":"1700018B08Rik","annotation":"RIKEN cDNA 1700018B08 gene."},{"id":"ENSMUSP00000127368","abundance":1.17,"rank":10452,"name":"C2cd2","annotation":"C2 domain-containing protein 2."},{"id":"ENSMUSP00000098741","abundance":1.16,"rank":10453,"name":"Gm10439","annotation":"Predicted gene 10439."},{"id":"ENSMUSP00000040596","abundance":1.16,"rank":10454,"name":"Palm","annotation":"Paralemmin-1; Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner."},{"id":"ENSMUSP00000054752","abundance":1.16,"rank":10455,"name":"Olfr1414","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149576","abundance":1.16,"rank":10456,"name":"Olfr1416","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000108620","abundance":1.16,"rank":10457,"name":"Tsc22d3","annotation":"TSC22 domain family protein 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 and isoform 4 inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids by binding  [...] "},{"id":"ENSMUSP00000108360","abundance":1.16,"rank":10458,"name":"Gm15091","annotation":"Predicted gene 15091."},{"id":"ENSMUSP00000020877","abundance":1.16,"rank":10459,"name":"Twistnb","annotation":"DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters; Belongs to the eukaryotic RPA43 RNA polymerase subunit family."},{"id":"ENSMUSP00000081043","abundance":1.16,"rank":10460,"name":"Tacc1","annotation":"Transforming acidic coiled-coil-containing protein 1; Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors (By similarity). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. Belongs to the TACC family."},{"id":"ENSMUSP00000031674","abundance":1.16,"rank":10461,"name":"Tfpi2","annotation":"Tissue factor pathway inhibitor 2; May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin (By similarity)."},{"id":"ENSMUSP00000058363","abundance":1.16,"rank":10462,"name":"B3galnt1","annotation":"UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine onto globotriaosylceramide. Plays a critical role in preimplantation stage embryonic development ; Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000067737","abundance":1.16,"rank":10463,"name":"Ldb2","annotation":"LIM domain-binding protein 2; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors."},{"id":"ENSMUSP00000129418","abundance":1.16,"rank":10464,"name":"Cd276","annotation":"CD276 antigen; Modulates T-cell-mediated immune responses and the development of acute and chronic transplant rejection. Plays a positive regulatory role in bone formation and has a dual role in the bone- immune interface. Induces antitumor immunity as it activates both acquired and innate immunity leading to natural killer cell and CD8 T- cell dependent killing of tumor cells. Belongs to the immunoglobulin superfamily. BTN/MOG family."},{"id":"ENSMUSP00000047927","abundance":1.16,"rank":10465,"name":"Abca5","annotation":"ATP-binding cassette sub-family A member 5; May play a role in the processing of autolysosomes."},{"id":"ENSMUSP00000035058","abundance":1.16,"rank":10466,"name":"Cspg5","annotation":"Chondroitin sulfate proteoglycan 5; May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation."},{"id":"ENSMUSP00000002079","abundance":1.16,"rank":10467,"name":"Plxnb3","annotation":"Plexin-B3; Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA- mediated inactivation of RAC1 (By similarity). Seem to be non-essential for normal development and function of the central nervous system."},{"id":"ENSMUSP00000023666","abundance":1.16,"rank":10468,"name":"Chaf1b","annotation":"Chromatin assembly factor 1 subunit B; Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (By similarity)."},{"id":"ENSMUSP00000101481","abundance":1.16,"rank":10469,"name":"Grhl3","annotation":"Grainyhead-like protein 3 homolog; Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. Essential for epidermal differentiation and barrier formation at the end of embryogenesis with TGM3 as critical direct target. Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events such as eyelid fusion and epidermal wound repair. Despite being dispen [...] "},{"id":"ENSMUSP00000128224","abundance":1.16,"rank":10470,"name":"Atp13a3","annotation":"Probable cation-transporting ATPase 13A3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily."},{"id":"ENSMUSP00000030849","abundance":1.16,"rank":10471,"name":"Fam126a","annotation":"Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway."},{"id":"ENSMUSP00000156906","abundance":1.16,"rank":10472,"name":"Cramp1l","annotation":"Protein cramped-like."},{"id":"ENSMUSP00000055237","abundance":1.16,"rank":10473,"name":"Syt12","annotation":"Synaptotagmin-12; Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (By similarity). Essential for mossy-fiber long-term potentiation in the hippocampus."},{"id":"ENSMUSP00000101406","abundance":1.16,"rank":10474,"name":"Fhad1","annotation":"Forkhead-associated domain-containing protein 1."},{"id":"ENSMUSP00000035234","abundance":1.16,"rank":10475,"name":"1700102P08Rik","annotation":"Uncharacterized protein C3orf62 homolog."},{"id":"ENSMUSP00000062588","abundance":1.16,"rank":10476,"name":"Ccr10","annotation":"C-C chemokine receptor type 10; Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level."},{"id":"ENSMUSP00000121239","abundance":1.16,"rank":10477,"name":"Cnot6","annotation":"CCR4-NOT transcription complex subunit 6; Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytopl [...] "},{"id":"ENSMUSP00000115883","abundance":1.16,"rank":10478,"name":"Vegfa","annotation":"Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor  [...] "},{"id":"ENSMUSP00000030490","abundance":1.16,"rank":10479,"name":"Stil","annotation":"SCL-interrupting locus protein homolog; Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long- term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formatio [...] "},{"id":"ENSMUSP00000028252","abundance":1.16,"rank":10480,"name":"Grb14","annotation":"Growth factor receptor-bound protein 14; Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal (By similarity); Belongs to the GRB7/10/14 family."},{"id":"ENSMUSP00000056778","abundance":1.16,"rank":10481,"name":"E2f8","annotation":"Transcription factor E2F8; Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta a [...] "},{"id":"ENSMUSP00000051049","abundance":1.16,"rank":10482,"name":"Bag5","annotation":"BAG family molecular chaperone regulator 5; May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity)."},{"id":"ENSMUSP00000126473","abundance":1.16,"rank":10483,"name":"Luzp4","annotation":"Leucine zipper protein 4."},{"id":"ENSMUSP00000059947","abundance":1.16,"rank":10484,"name":"Ulk3","annotation":"Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as we [...] "},{"id":"ENSMUSP00000042199","abundance":1.16,"rank":10485,"name":"Cdh10","annotation":"Cadherin-10; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."},{"id":"ENSMUSP00000133816","abundance":1.16,"rank":10486,"name":"Rbm38","annotation":"RNA-binding protein 38; RNA-binding protein that specifically bind the 3'-UTR of CDKN1A transcripts, leading to maintain the stability of CDKN1A transcripts, thereby acting as a mediator of the p53/TP53 family to regulate CDKN1A. CDKN1A is a cyclin-dependent kinase inhibitor transcriptionally regulated by the p53/TP53 family to induce cell cycle arrest. Has the ability to induce cell cycle arrest in G1 and maintain the stability of CDKN1A transcripts induced by p53/TP53. Also acts as a mRNA splicing factor. Specifically regulates the expression of FGFR2- IIIb, an epithelial cell-specif [...] "},{"id":"ENSMUSP00000014505","abundance":1.16,"rank":10487,"name":"Mertk","annotation":"Tyrosine-protein kinase Mer; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation [...] "},{"id":"ENSMUSP00000025568","abundance":1.16,"rank":10488,"name":"Tmem138","annotation":"Transmembrane protein 138; Required for ciliogenesis."},{"id":"ENSMUSP00000097428","abundance":1.16,"rank":10489,"name":"Olfr74","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000110563","abundance":1.15,"rank":10490,"name":"Adcy5","annotation":"Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates signaling downstream of ADRB1. Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion."},{"id":"ENSMUSP00000084977","abundance":1.15,"rank":10491,"name":"Prune2","annotation":"Protein prune homolog 2; May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells."},{"id":"ENSMUSP00000106936","abundance":1.15,"rank":10492,"name":"Usp21","annotation":"Ubiquitin carboxyl-terminal hydrolase 21; Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination. Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. Deubiquitinates BAZ2A/TIP5 leading to its stabilization (By similarity). Belongs to the peptidase C19 family. U [...] "},{"id":"ENSMUSP00000109229","abundance":1.15,"rank":10493,"name":"Adgrf5","annotation":"Adhesion G protein-coupled receptor F5; Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function."},{"id":"ENSMUSP00000138082","abundance":1.15,"rank":10494,"name":"Fam193a","annotation":"Protein FAM193A; Belongs to the FAM193 family."},{"id":"ENSMUSP00000070619","abundance":1.15,"rank":10495,"name":"Rad18","annotation":"E3 ubiquitin-protein ligase RAD18; E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA- associated PCNA on 'Lys-164'. Has ssDNA binding activity."},{"id":"ENSMUSP00000086933","abundance":1.15,"rank":10496,"name":"Ap5s1","annotation":"AP-5 complex subunit sigma-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport."},{"id":"ENSMUSP00000081567","abundance":1.15,"rank":10497,"name":"Wdr11","annotation":"WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of GLI3 and cooperates with the transcription factor EMX1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)- derived vesicles. WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1 (By similarity)."},{"id":"ENSMUSP00000107841","abundance":1.15,"rank":10498,"name":"Rad51ap1","annotation":"RAD51-associated protein 1; May participate in a common DNA damage response pathway associated with the activation of homologous recombination and double- strand break repair. Functionally cooperates with PALB2 in promoting of D-loop formation by RAD51. Binds to single and double stranded DNA, and is capable of aggregating DNA. Also binds RNA (By similarity)."},{"id":"ENSMUSP00000107447","abundance":1.15,"rank":10499,"name":"Trim71","annotation":"E3 ubiquitin-protein ligase TRIM71; E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. In addition, participates in post- transcriptional mRNA repression in a miRNA independent mechanism. Required to maintain proliferation and prevent premature differentiatio [...] "},{"id":"ENSMUSP00000017881","abundance":1.15,"rank":10500,"name":"Mmp9","annotation":"Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). Belongs to the peptidase M10A family."},{"id":"ENSMUSP00000048443","abundance":1.15,"rank":10501,"name":"Ppp1r21","annotation":"Protein phosphatase 1 regulatory subunit 21; utative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway."},{"id":"ENSMUSP00000103234","abundance":1.15,"rank":10502,"name":"Tmem245","annotation":"Transmembrane protein 245."},{"id":"ENSMUSP00000036768","abundance":1.15,"rank":10503,"name":"Vash2","annotation":"Tubulinyl-Tyr carboxypeptidase 2; Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis. Plays a role in axon formation."},{"id":"ENSMUSP00000061900","abundance":1.15,"rank":10504,"name":"Ifi209","annotation":"Pyrin and HIN domain-containing protein 1."},{"id":"ENSMUSP00000083742","abundance":1.15,"rank":10505,"name":"Dhx57","annotation":"Putative ATP-dependent RNA helicase DHX57; Probable ATP-binding RNA helicase."},{"id":"ENSMUSP00000099121","abundance":1.15,"rank":10506,"name":"Ccdc160","annotation":"Coiled-coil domain-containing protein 160; Belongs to the CCDC160 family."},{"id":"ENSMUSP00000085113","abundance":1.15,"rank":10507,"name":"Olfr1436","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000113306","abundance":1.15,"rank":10508,"name":"Mterf1a","annotation":"Transcription termination factor 1a, mitochondrial; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand."},{"id":"ENSMUSP00000032441","abundance":1.15,"rank":10509,"name":"Ccdc91","annotation":"Coiled-coil domain-containing protein 91; Involved in the regulation of membrane traffic through the trans-Golgi network (TGN). Functions in close cooperation with the GGAs in the sorting of hydrolases to lysosomes."},{"id":"ENSMUSP00000124611","abundance":1.15,"rank":10510,"name":"Cnih3","annotation":"Protein cornichon homolog 3; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization (By similarity)."},{"id":"ENSMUSP00000024736","abundance":1.15,"rank":10511,"name":"Sgo1","annotation":"Shugoshin 1; Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congressi [...] "},{"id":"ENSMUSP00000126321","abundance":1.15,"rank":10512,"name":"Dnajc1","annotation":"DnaJ homolog subfamily C member 1; May modulate protein synthesis."},{"id":"ENSMUSP00000135408","abundance":1.15,"rank":10513,"name":"Mterf1b","annotation":"Transcription termination factor 1b, mitochondrial; Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand."},{"id":"ENSMUSP00000065168","abundance":1.15,"rank":10514,"name":"Nkapl","annotation":"NKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis; Belongs to the NKAP family."},{"id":"ENSMUSP00000116130","abundance":1.15,"rank":10515,"name":"Abhd13","annotation":"Protein ABHD13."},{"id":"ENSMUSP00000051375","abundance":1.15,"rank":10516,"name":"Fam13c","annotation":"Protein FAM13C; Belongs to the FAM13 family."},{"id":"ENSMUSP00000056145","abundance":1.15,"rank":10517,"name":"Ckap2l","annotation":"Cytoskeleton-associated protein 2-like; Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells."},{"id":"ENSMUSP00000103786","abundance":1.15,"rank":10518,"name":"Zbtb32","annotation":"Zinc finger and BTB domain-containing protein 32; DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor (By similarity). Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T- cells."},{"id":"ENSMUSP00000009707","abundance":1.15,"rank":10519,"name":"Tor2a","annotation":"Torsin-2A; Belongs to the ClpA/ClpB family. Torsin subfamily."},{"id":"ENSMUSP00000044653","abundance":1.15,"rank":10520,"name":"Cd3eap","annotation":"DNA-directed RNA polymerase I subunit RPA34; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Involved in UBTF-activated transcription, presumably at a step following PIC formation; Belongs to the eukaryotic RPA34 RNA polymerase subunit family."},{"id":"ENSMUSP00000100743","abundance":1.14,"rank":10521,"name":"F8a","annotation":"40-kDa huntingtin-associated protein; RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity). The HTT-F8A1/F8A2/F8A3- RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility."},{"id":"ENSMUSP00000051118","abundance":1.14,"rank":10522,"name":"Hes5","annotation":"Transcription factor HES-5; Transcriptional repressor of genes that require a bHLH protein for their transcription. Plays an important role as neurogenesis negative regulator."},{"id":"ENSMUSP00000023285","abundance":1.14,"rank":10523,"name":"Tymp","annotation":"Thymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity); Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family."},{"id":"ENSMUSP00000030817","abundance":1.14,"rank":10524,"name":"Car6","annotation":"Carbonic anhydrase 6; Reversible hydration of carbon dioxide. Its role in saliva is unknown."},{"id":"ENSMUSP00000110827","abundance":1.14,"rank":10525,"name":"Rhox2f","annotation":"Reproductive homeobox 2F."},{"id":"ENSMUSP00000023749","abundance":1.14,"rank":10526,"name":"Tmbim6","annotation":"Bax inhibitor 1; Suppressor of apoptosis (By similarity). Modulates unfolded protein response signaling (By similarity). Modulates ER calcium homeostasis by acting as a calcium-leak channel (By similarity). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation."},{"id":"ENSMUSP00000048453","abundance":1.14,"rank":10527,"name":"Rasl10a","annotation":"Ras-like protein family member 10A; Potent inhibitor of cellular proliferation."},{"id":"ENSMUSP00000042025","abundance":1.14,"rank":10528,"name":"D11Wsu47e","annotation":"Uncharacterized protein C17orf80 homolog."},{"id":"ENSMUSP00000092041","abundance":1.14,"rank":10529,"name":"Selenom","annotation":"Selenoprotein M; May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation."},{"id":"ENSMUSP00000098746","abundance":1.14,"rank":10530,"name":"Gm15127","annotation":"Predicted gene 15127."},{"id":"ENSMUSP00000108649","abundance":1.14,"rank":10531,"name":"Rnf128","annotation":"E3 ubiquitin-protein ligase RNF128; E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down- regulation of these cytoslele [...] "},{"id":"ENSMUSP00000037075","abundance":1.14,"rank":10532,"name":"Gmeb2","annotation":"Glucocorticoid modulatory element-binding protein 2; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity)."},{"id":"ENSMUSP00000070601","abundance":1.14,"rank":10533,"name":"1700030J22Rik","annotation":"Uncharacterized protein C16orf46 homolog."},{"id":"ENSMUSP00000021961","abundance":1.14,"rank":10534,"name":"Catsper3","annotation":"Cation channel sperm-associated protein 3; Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization."},{"id":"ENSMUSP00000029186","abundance":1.14,"rank":10535,"name":"Dhx35","annotation":"DEAH (Asp-Glu-Ala-His) box polypeptide 35."},{"id":"ENSMUSP00000101449","abundance":1.14,"rank":10536,"name":"Sh2d5","annotation":"SH2 domain-containing protein 5; May be involved in synaptic plasticity regulation through the control of Rac-GTP levels."},{"id":"ENSMUSP00000075488","abundance":1.14,"rank":10537,"name":"Srrm4","annotation":"Serine/arginine repetitive matrix protein 4; Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural- specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural- specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce REST isofo [...] "},{"id":"ENSMUSP00000069187","abundance":1.14,"rank":10538,"name":"Gja6","annotation":"Gap junction alpha-6 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell."},{"id":"ENSMUSP00000128127","abundance":1.14,"rank":10539,"name":"Coch","annotation":"Cochlin; Plays a role in the control of cell shape and motility in the trabecular meshwork."},{"id":"ENSMUSP00000027785","abundance":1.14,"rank":10540,"name":"Sdccag8","annotation":"Serologically defined colon cancer antigen 8 homolog; Plays a role in the establishment of cell polarity and epithelial lumen formation. Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis."},{"id":"ENSMUSP00000047667","abundance":1.14,"rank":10541,"name":"Mlc1","annotation":"Membrane protein MLC1; Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx."},{"id":"ENSMUSP00000072808","abundance":1.14,"rank":10542,"name":"Mppe1","annotation":"Metallophosphoesterase 1; Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI- anchor proteins (By similarity)."},{"id":"ENSMUSP00000037000","abundance":1.14,"rank":10543,"name":"Mcph1","annotation":"Microcephalin; Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex (By similarity)."},{"id":"ENSMUSP00000026978","abundance":1.14,"rank":10544,"name":"Xiap","annotation":"E3 ubiquitin-protein ligase XIAP; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligas [...] "},{"id":"ENSMUSP00000085832","abundance":1.14,"rank":10545,"name":"Magea10","annotation":"Melanoma antigen family A, 10."},{"id":"ENSMUSP00000021141","abundance":1.14,"rank":10546,"name":"P2rx1","annotation":"P2X purinoceptor 1; Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity)."},{"id":"ENSMUSP00000036729","abundance":1.14,"rank":10547,"name":"2010003K11Rik","annotation":"Uncharacterized protein C11orf86 homolog."},{"id":"ENSMUSP00000149704","abundance":1.14,"rank":10548,"name":"Olfr672","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000040977","abundance":1.14,"rank":10549,"name":"Traf3ip3","annotation":"TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3- mediated JNK activation."},{"id":"ENSMUSP00000027061","abundance":1.14,"rank":10550,"name":"Il17a","annotation":"Interleukin-17A; Ligand for IL17RA. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (By similarity). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (By similarity)."},{"id":"ENSMUSP00000151909","abundance":1.14,"rank":10551,"name":"Cep85l","annotation":"Centrosomal protein 85-like."},{"id":"ENSMUSP00000033169","abundance":1.14,"rank":10552,"name":"Cdr2","annotation":"Cerebellar degeneration-related protein 2."},{"id":"ENSMUSP00000060505","abundance":1.14,"rank":10553,"name":"Adam30","annotation":"A disintegrin and metallopeptidase domain 30."},{"id":"ENSMUSP00000035216","abundance":1.14,"rank":10554,"name":"Uba7","annotation":"Ubiquitin-like modifier-activating enzyme 7."},{"id":"ENSMUSP00000032931","abundance":1.14,"rank":10555,"name":"Fchsd2","annotation":"F-BAR and double SH3 domains protein 2; Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor. Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling. Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits. Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate  [...] "},{"id":"ENSMUSP00000082855","abundance":1.14,"rank":10556,"name":"Stat2","annotation":"Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] "},{"id":"ENSMUSP00000103791","abundance":1.13,"rank":10557,"name":"Bbs7","annotation":"Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the gua [...] "},{"id":"ENSMUSP00000098740","abundance":1.13,"rank":10558,"name":"Gm15097","annotation":"Predicted gene 15097."},{"id":"ENSMUSP00000121848","abundance":1.13,"rank":10559,"name":"Clec5a","annotation":"C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses."},{"id":"ENSMUSP00000077517","abundance":1.13,"rank":10560,"name":"Olfr1355","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000112930","abundance":1.13,"rank":10561,"name":"Spock3","annotation":"Testican-3; May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion (By similarity)."},{"id":"ENSMUSP00000072382","abundance":1.13,"rank":10562,"name":"Alg11","annotation":"GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain (By similarity); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily."},{"id":"ENSMUSP00000031317","abundance":1.13,"rank":10563,"name":"Rassf6","annotation":"Ras association domain-containing protein 6; Involved in the induction of apoptosis. May act as a Ras effector protein. May suppress the serum-induced basal levels of NF- kappa-B."},{"id":"ENSMUSP00000007559","abundance":1.13,"rank":10564,"name":"Gatad1","annotation":"GATA zinc finger domain-containing protein 1; Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3)."},{"id":"ENSMUSP00000025761","abundance":1.13,"rank":10565,"name":"Cabp4","annotation":"Calcium-binding protein 4; Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release in photoreceptor synaptic terminals and in auditory transmission. Modulator of CACNA1D and CACNA1F, suppressing the calcium-dependent inactivation and shifting the activation range to more hyperpolarized voltages."},{"id":"ENSMUSP00000078705","abundance":1.13,"rank":10566,"name":"Tnfrsf11b","annotation":"Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis."},{"id":"ENSMUSP00000130874","abundance":1.13,"rank":10567,"name":"Chrm2","annotation":"Muscarinic acetylcholine receptor M2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol (By similarity). Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHR [...] "},{"id":"ENSMUSP00000127305","abundance":1.13,"rank":10568,"name":"Armcx2","annotation":"Armadillo repeat-containing X-linked protein 2; May regulate the dynamics and distribution of mitochondria in neural cells."},{"id":"ENSMUSP00000027379","abundance":1.13,"rank":10569,"name":"Xrcc5","annotation":"X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] "},{"id":"ENSMUSP00000076130","abundance":1.13,"rank":10570,"name":"Plk3","annotation":"Serine/threonine-protein kinase PLK3; Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosi [...] "},{"id":"ENSMUSP00000058631","abundance":1.13,"rank":10571,"name":"Tcim","annotation":"Transcriptional and immune response regulator; Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcri [...] "},{"id":"ENSMUSP00000026671","abundance":1.13,"rank":10572,"name":"Rptor","annotation":"Regulatory-associated protein of mTOR; Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1- TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTO [...] "},{"id":"ENSMUSP00000058101","abundance":1.13,"rank":10573,"name":"Olfr829","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000152336","abundance":1.13,"rank":10574,"name":"Rps6kl1","annotation":"Ribosomal protein S6 kinase-like 1."},{"id":"ENSMUSP00000037970","abundance":1.13,"rank":10575,"name":"Bmp2k","annotation":"BMP-2-inducible protein kinase; May be involved in osteoblast differentiation."},{"id":"ENSMUSP00000099606","abundance":1.13,"rank":10576,"name":"Fmn1","annotation":"Formin-1; Plays a role in the formation of adherens junction and the polymerization of linear actin cables."},{"id":"ENSMUSP00000041985","abundance":1.13,"rank":10577,"name":"Tex2","annotation":"Testis-expressed protein 2."},{"id":"ENSMUSP00000033142","abundance":1.13,"rank":10578,"name":"Ptpn5","annotation":"Tyrosine-protein phosphatase non-receptor type 5; May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily."},{"id":"ENSMUSP00000072583","abundance":1.13,"rank":10579,"name":"Sox6","annotation":"Transcription factor SOX-6; Transcriptional activator. Binds specifically to the DNA sequence 5'-AACAAT-3'. Plays a key role in several developmental processes, including neurogenesis and skeleton formation."},{"id":"ENSMUSP00000150070","abundance":1.13,"rank":10580,"name":"Olfr657","annotation":"Olfactory receptor Olfr657."},{"id":"ENSMUSP00000002280","abundance":1.13,"rank":10581,"name":"Smg9","annotation":"Protein SMG9; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8 (By similarity). Plays a role in brain, heart, and eye development."},{"id":"ENSMUSP00000058084","abundance":1.13,"rank":10582,"name":"Kif2b","annotation":"Kinesin-like protein KIF2B; Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement during mitosis. Has microtubule depolymerization activity. Plays a role in chromosome congression."},{"id":"ENSMUSP00000048825","abundance":1.13,"rank":10583,"name":"Klf16","annotation":"Krueppel-like factor 16; Transcription factor that binds GC and GT boxes in the D1A, D2 and D3 dopamine receptor promoters and displaces Sp1 and Sp3 from these sequences. It modulates dopaminergic transmission in the brain by repressing or activating transcription from several different promoters depending on cellular context; Belongs to the Sp1 C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000036656","abundance":1.13,"rank":10584,"name":"Sgpp2","annotation":"Sphingosine-1-phosphate phosphatase 2; Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (Probable). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity). Plays a role in the regulation of pancreatic isl [...] "},{"id":"ENSMUSP00000065533","abundance":1.13,"rank":10585,"name":"Gpr173","annotation":"Probable G-protein coupled receptor 173; Is a receptor for the SMIM20 derived peptides Phoenixin-14 and Phoenixin-20. It mediates the Phoenixin-14 and Phoenixin-20 augmentation of gonadotropin-releasing hormone (GNRH) signaling in the hypothalamus and pituitary gland. In the ovary, it mediates the effects of Phoenixin-14 and Phoenixin-20 induced granulosa cell proliferation during follicular growth."},{"id":"ENSMUSP00000099548","abundance":1.13,"rank":10586,"name":"Epb42","annotation":"Erythrocyte membrane protein band 4.2; Probably plays an important role in the regulation of erythrocyte shape and mechanical properties; Belongs to the transglutaminase superfamily. Transglutaminase family."},{"id":"ENSMUSP00000021929","abundance":1.13,"rank":10587,"name":"Habp4","annotation":"Intracellular hyaluronan-binding protein 4; RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress. Plays a role in pre- mRNA splicing regulation. Binds (via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step. Seems to play a role in PML-nuclear bodies formation (By similarity)."},{"id":"ENSMUSP00000158324","abundance":1.13,"rank":10588,"name":"Cd226","annotation":"CD226 antigen; Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T- lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding."},{"id":"ENSMUSP00000086074","abundance":1.13,"rank":10589,"name":"Zfp945","annotation":"Zinc finger protein 945."},{"id":"ENSMUSP00000021860","abundance":1.13,"rank":10590,"name":"Ly86","annotation":"Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression."},{"id":"ENSMUSP00000021155","abundance":1.13,"rank":10591,"name":"Tekt1","annotation":"Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity)."},{"id":"ENSMUSP00000084578","abundance":1.13,"rank":10592,"name":"Ppp1r3c","annotation":"Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types."},{"id":"ENSMUSP00000105998","abundance":1.13,"rank":10593,"name":"Prl","annotation":"Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation."},{"id":"ENSMUSP00000078863","abundance":1.13,"rank":10594,"name":"Phex","annotation":"Phosphate-regulating neutral endopeptidase PHEX; Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (By similarity). Cleaves ASARM peptides between Ser and Glu or Asp residues (By similarity). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preven [...] "},{"id":"ENSMUSP00000113913","abundance":1.13,"rank":10595,"name":"Zfr2","annotation":"Zinc finger RNA-binding protein 2."},{"id":"ENSMUSP00000126777","abundance":1.13,"rank":10596,"name":"Senp6","annotation":"Sentrin-specific protease 6; Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, [...] "},{"id":"ENSMUSP00000072121","abundance":1.12,"rank":10597,"name":"Etnppl","annotation":"Ethanolamine-phosphate phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of phosphoethanolamine, converting it to ammonia, inorganic phosphate and acetaldehyde."},{"id":"ENSMUSP00000141128","abundance":1.12,"rank":10598,"name":"Muc2","annotation":"Mucin-2; Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer."},{"id":"ENSMUSP00000033900","abundance":1.12,"rank":10599,"name":"Rab20","annotation":"Ras-related protein Rab-20; Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays a role in the fusion of phagosomes with lysosomes (By similarity)."},{"id":"ENSMUSP00000103853","abundance":1.12,"rank":10600,"name":"Klhl32","annotation":"Kelch-like 32."},{"id":"ENSMUSP00000149588","abundance":1.12,"rank":10601,"name":"Olfr33","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000099096","abundance":1.12,"rank":10602,"name":"Zfp449","annotation":"Zinc finger protein 449."},{"id":"ENSMUSP00000132164","abundance":1.12,"rank":10603,"name":"Tmem102","annotation":"Transmembrane protein 102; Selectively involved in CSF2 deprivation-induced apoptosis via a mitochondria-dependent pathway."},{"id":"ENSMUSP00000069019","abundance":1.12,"rank":10604,"name":"Prr18","annotation":"Proline-rich protein 18."},{"id":"ENSMUSP00000073164","abundance":1.12,"rank":10605,"name":"Syt9","annotation":"Synaptotagmin-9; May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis; Belongs to the synaptotagmin family."},{"id":"ENSMUSP00000066338","abundance":1.12,"rank":10606,"name":"Chrna4","annotation":"Neuronal acetylcholine receptor subunit alpha-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub- subfamily."},{"id":"ENSMUSP00000063677","abundance":1.12,"rank":10607,"name":"Plekho2","annotation":"Pleckstrin homology domain-containing family O member 2."},{"id":"ENSMUSP00000017530","abundance":1.12,"rank":10608,"name":"Traf4","annotation":"TNF receptor-associated factor 4; Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions (By similarity). Required for normal skeleton development, and for normal development of the respiratory tract."},{"id":"ENSMUSP00000094176","abundance":1.12,"rank":10609,"name":"Morc2a","annotation":"ATPase MORC2A; Essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down- regulation of host gene expression. During DNA damage response, regula [...] "},{"id":"ENSMUSP00000026239","abundance":1.12,"rank":10610,"name":"Poll","annotation":"DNA polymerase lambda; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity."},{"id":"ENSMUSP00000077779","abundance":1.12,"rank":10611,"name":"Lrrc58","annotation":"Leucine-rich repeat-containing protein 58."},{"id":"ENSMUSP00000035196","abundance":1.12,"rank":10612,"name":"Hemk1","annotation":"MTRF1L release factor glutamine methyltransferase; N5-glutamine methyltransferase responsible for the methylation of the glutamine residue in the universally conserved GGQ motif of the mitochondrial translation release factor MTRF1L."},{"id":"ENSMUSP00000034702","abundance":1.12,"rank":10613,"name":"Lysmd2","annotation":"LysM and putative peptidoglycan-binding domain-containing protein 2."},{"id":"ENSMUSP00000031588","abundance":1.12,"rank":10614,"name":"Usp30","annotation":"Ubiquitin carboxyl-terminal hydrolase 30; Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys- 6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (By similarity). Acts as negative regulato [...] "},{"id":"ENSMUSP00000120421","abundance":1.12,"rank":10615,"name":"Nos1","annotation":"Nitric oxide synthase, brain; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Isoform NNOS Mu may be an effector enzyme for the dystrophin complex."},{"id":"ENSMUSP00000135716","abundance":1.12,"rank":10616,"name":"Pate13","annotation":"Prostate and testis-expressed 13."},{"id":"ENSMUSP00000070606","abundance":1.12,"rank":10617,"name":"Lrrc49","annotation":"Leucine-rich repeat-containing protein 49."},{"id":"ENSMUSP00000081826","abundance":1.12,"rank":10618,"name":"Fut9","annotation":"4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal lactosamine unit of a glycoprotein or a glycolipid-linked polylactosamine chains through an alpha-1,3 glycosidic linkage and participates in particular to the Lewis x (Lex)/CD15 epitope biosynthesis in neurons which allows cell differentiation, cell adhesion, and initiation of neurite outgrowth. Also fucosylates di-, tri- and tetraantennary N-glycans linked to glycoproteins and the inner lacto [...] "},{"id":"ENSMUSP00000061125","abundance":1.12,"rank":10619,"name":"Gm49486","annotation":"Galectin."},{"id":"ENSMUSP00000038485","abundance":1.12,"rank":10620,"name":"Rangrf","annotation":"Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (By similarity). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes."},{"id":"ENSMUSP00000031937","abundance":1.12,"rank":10621,"name":"Moxd2","annotation":"DBH-like monooxygenase protein 2."},{"id":"ENSMUSP00000115599","abundance":1.12,"rank":10622,"name":"Rreb1","annotation":"Ras-responsive element-binding protein 1; Transcription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1 (By similarity). Binds specifically to the allelic variant of the CDKN2A promoter present in Balb/c mice, which leads to a down-regulation of CDKN2A expression in this strain, and, as a consequence, to an eleva [...] "},{"id":"ENSMUSP00000042904","abundance":1.12,"rank":10623,"name":"Cep126","annotation":"Centrosomal protein of 126 kDa; Participate in cytokinesis (By similarity). Necessary for microtubules and mitotic spindle organization (By similarity). Involved in primary cilium formation (By similarity)."},{"id":"ENSMUSP00000084430","abundance":1.12,"rank":10624,"name":"Stk36","annotation":"Serine/threonine-protein kinase 36; Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of c [...] "},{"id":"ENSMUSP00000020015","abundance":1.12,"rank":10625,"name":"Nmbr","annotation":"Neuromedin-B receptor; Receptor for neuromedin-B; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000035321","abundance":1.11,"rank":10626,"name":"Ucn","annotation":"Urocortin; Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (By similarity). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds. Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family."},{"id":"ENSMUSP00000077106","abundance":1.11,"rank":10627,"name":"Sgcg","annotation":"Gamma-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix."},{"id":"ENSMUSP00000111498","abundance":1.11,"rank":10628,"name":"Dtna","annotation":"Dystrobrevin alpha; Involved in synapse maturation and required for normal muscle function."},{"id":"ENSMUSP00000099549","abundance":1.11,"rank":10629,"name":"Crocc","annotation":"Rootletin; Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Furthermore, is required for the correct positioning of the cilium basal body relative to the cell nucleus, to allow for ciliogenesis (By similarity). Contributes to centrosome cohesion before mitosis (By similarity)."},{"id":"ENSMUSP00000075107","abundance":1.11,"rank":10630,"name":"Ado","annotation":"2-aminoethanethiol dioxygenase."},{"id":"ENSMUSP00000150374","abundance":1.11,"rank":10631,"name":"Olfr1354","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000140404","abundance":1.11,"rank":10632,"name":"Ncf2","annotation":"Neutrophil cytosol factor 2; NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production)."},{"id":"ENSMUSP00000025682","abundance":1.11,"rank":10633,"name":"Lipn","annotation":"Lipase member N; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000092034","abundance":1.11,"rank":10634,"name":"Mn1","annotation":"Transcriptional activator MN1; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for normal growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull. May play a role in tumor suppression (By similarity)."},{"id":"ENSMUSP00000007797","abundance":1.11,"rank":10635,"name":"Gabrb2","annotation":"Gamma-aminobutyric acid receptor subunit beta-2; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The al [...] "},{"id":"ENSMUSP00000039011","abundance":1.11,"rank":10636,"name":"Trim7","annotation":"E3 ubiquitin-protein ligase TRIM7; E3 ubiquitin-protein ligase (By similarity). Mediates 'Lys- 63'-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation (By similarity); Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000105149","abundance":1.11,"rank":10637,"name":"Vstm2l","annotation":"V-set and transmembrane domain-containing protein 2-like protein."},{"id":"ENSMUSP00000025142","abundance":1.11,"rank":10638,"name":"Esco1","annotation":"N-acetyltransferase ESCO1; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3."},{"id":"ENSMUSP00000030696","abundance":1.11,"rank":10639,"name":"Fam76a","annotation":"Protein FAM76A."},{"id":"ENSMUSP00000038514","abundance":1.11,"rank":10640,"name":"Irs2","annotation":"Insulin receptor substrate 2; May mediate the control of various cellular processes by insulin."},{"id":"ENSMUSP00000043369","abundance":1.11,"rank":10641,"name":"Il5","annotation":"Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells."},{"id":"ENSMUSP00000042291","abundance":1.11,"rank":10642,"name":"Chd6","annotation":"Chromodomain-helicase-DNA-binding protein 6; DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2."},{"id":"ENSMUSP00000072425","abundance":1.11,"rank":10643,"name":"Nkx2-9","annotation":"Homeobox protein Nkx-2.8; Possible role in the specification of a distinct subset of neurons."},{"id":"ENSMUSP00000063397","abundance":1.11,"rank":10644,"name":"Nrk","annotation":"Nik-related protein kinase; May phosphorylate cofilin-1 and induce actin polymerization through this process, during the late stages of embryogenesis. Involved in the TNF-alpha-induced signaling pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily."},{"id":"ENSMUSP00000033020","abundance":1.11,"rank":10645,"name":"Acer3","annotation":"Alkaline ceramidase 3; Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4- ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1- [...] "},{"id":"ENSMUSP00000110498","abundance":1.11,"rank":10646,"name":"Taf11","annotation":"Transcription initiation factor TFIID subunit 11; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively); Belongs to the TAF11 family."},{"id":"ENSMUSP00000025002","abundance":1.11,"rank":10647,"name":"Tekt4","annotation":"Tektin-4; May be a structural component of the sperm flagellum. Contributes to normal sperm motility."},{"id":"ENSMUSP00000039313","abundance":1.11,"rank":10648,"name":"Poglut3","annotation":"Protein O-glucosyltransferase 3; Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C. Can also catalyze the transfer of xylose from UDP-xylose but less efficiently. Specifically targets extracellular EGF repeats of proteins such as NOTCH1 and NOTCH3. May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway."},{"id":"ENSMUSP00000153076","abundance":1.11,"rank":10649,"name":"Actr8","annotation":"Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Belongs to the actin family. ARP8 subfamily."},{"id":"ENSMUSP00000031211","abundance":1.11,"rank":10650,"name":"Smr3a","annotation":"Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification."},{"id":"ENSMUSP00000128400","abundance":1.11,"rank":10651,"name":"Snrpe","annotation":"Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development."},{"id":"ENSMUSP00000084857","abundance":1.11,"rank":10652,"name":"Trpm3","annotation":"Transient receptor potential cation channel, subfamily M, member 3."},{"id":"ENSMUSP00000100595","abundance":1.11,"rank":10653,"name":"Papolb","annotation":"Poly(A) polymerase beta."},{"id":"ENSMUSP00000139406","abundance":1.11,"rank":10654,"name":"Il19","annotation":"Interleukin-19; May play some important roles in inflammatory responses. Up- regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family."},{"id":"ENSMUSP00000113720","abundance":1.11,"rank":10655,"name":"Syn3","annotation":"Synapsin-3; May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity); Belongs to the synapsin family."},{"id":"ENSMUSP00000013294","abundance":1.11,"rank":10656,"name":"Gfod2","annotation":"Glucose-fructose oxidoreductase domain-containing protein 2; Promotes matrix assembly; Belongs to the Gfo/Idh/MocA family."},{"id":"ENSMUSP00000075487","abundance":1.11,"rank":10657,"name":"Zfp58","annotation":"Zinc finger protein 58; May have a role during differentiation processes. Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000058371","abundance":1.11,"rank":10658,"name":"Tdrp","annotation":"Testis development-related protein; Contributes to normal sperm motility, but not essential for male fertility; Belongs to the TDRP family."},{"id":"ENSMUSP00000099851","abundance":1.11,"rank":10659,"name":"Kank4","annotation":"KN motif and ankyrin repeat domain-containing protein 4; May be involved in the control of cytoskeleton formation by regulating actin polymerization."},{"id":"ENSMUSP00000108438","abundance":1.11,"rank":10660,"name":"Lrch2","annotation":"Leucine-rich repeat and calponin homology domain-containing protein 2; May play a role in the organization of the cytoskeleton."},{"id":"ENSMUSP00000002502","abundance":1.1,"rank":10661,"name":"Hltf","annotation":"Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity. This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'- linked polyubiquitination of chromatin-bound PCNA (By similarity)."},{"id":"ENSMUSP00000061278","abundance":1.1,"rank":10662,"name":"Ppm1e","annotation":"Protein phosphatase 1E; Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2. Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42 (By similarity). Dephosphorylates PRKAA2; Belongs to the PP2C family."},{"id":"ENSMUSP00000024543","abundance":1.1,"rank":10663,"name":"Hes7","annotation":"Transcription factor HES-7; Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation."},{"id":"ENSMUSP00000047291","abundance":1.1,"rank":10664,"name":"Olfml2b","annotation":"Olfactomedin-like protein 2B."},{"id":"ENSMUSP00000104390","abundance":1.1,"rank":10665,"name":"Slc35f3","annotation":"Putative thiamine transporter SLC35F3; May be a thiamine transporter. Belongs to the SLC35F solute transporter family."},{"id":"ENSMUSP00000016673","abundance":1.1,"rank":10666,"name":"Il10","annotation":"Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] "},{"id":"ENSMUSP00000031478","abundance":1.1,"rank":10667,"name":"Ddx51","annotation":"ATP-dependent RNA helicase DDX51; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits; Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily."},{"id":"ENSMUSP00000104931","abundance":1.1,"rank":10668,"name":"Nfatc3","annotation":"Nuclear factor of activated T-cells, cytoplasmic 3; Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Along with NFATC4, involved in embryonic heart development."},{"id":"ENSMUSP00000093914","abundance":1.1,"rank":10669,"name":"Tmprss12","annotation":"Transmembrane protease serine 12."},{"id":"ENSMUSP00000022207","abundance":1.1,"rank":10670,"name":"Elovl7","annotation":"Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] "},{"id":"ENSMUSP00000022344","abundance":1.1,"rank":10671,"name":"Ecd","annotation":"Protein ecdysoneless homolog; Regulator of p53/TP53 stability and function. Inhibits MDM2- mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (By similarity). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated ass [...] "},{"id":"ENSMUSP00000133273","abundance":1.1,"rank":10672,"name":"Pdzd7","annotation":"PDZ domain-containing protein 7; In cochlear developing hair cells, essential in organizing the USH2 complex at stereocilia ankle links. Blocks inhibition of adenylate cyclase activity mediated by ADGRV1."},{"id":"ENSMUSP00000100922","abundance":1.1,"rank":10673,"name":"Epyc","annotation":"Epiphycan; May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization."},{"id":"ENSMUSP00000087857","abundance":1.1,"rank":10674,"name":"Usp53","annotation":"Inactive ubiquitin carboxyl-terminal hydrolase 53; Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions. Has no peptidase activity."},{"id":"ENSMUSP00000134222","abundance":1.1,"rank":10675,"name":"Mex3a","annotation":"Mex3 RNA-binding family member A."},{"id":"ENSMUSP00000047616","abundance":1.1,"rank":10676,"name":"Fermt1","annotation":"Fermitin family homolog 1; Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites (By similarity)."},{"id":"ENSMUSP00000039205","abundance":1.1,"rank":10677,"name":"Pvr","annotation":"Poliovirus receptor."},{"id":"ENSMUSP00000003512","abundance":1.1,"rank":10678,"name":"Fcgrt","annotation":"IgG receptor FcRn large subunit p51; Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, [...] "},{"id":"ENSMUSP00000122219","abundance":1.1,"rank":10679,"name":"Prlr","annotation":"Prolactin receptor; This is a receptor for the anterior pituitary hormone prolactin."},{"id":"ENSMUSP00000105375","abundance":1.1,"rank":10680,"name":"Bpifa6","annotation":"BPI fold-containing family A, member 6."},{"id":"ENSMUSP00000102725","abundance":1.1,"rank":10681,"name":"Izumo3","annotation":"Izumo sperm-egg fusion protein 3."},{"id":"ENSMUSP00000059923","abundance":1.1,"rank":10682,"name":"Ankrd45","annotation":"Ankyrin repeat domain-containing protein 45."},{"id":"ENSMUSP00000111081","abundance":1.1,"rank":10683,"name":"Steap4","annotation":"Metalloreductase STEAP4; Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses. Associated with obesity and insulin-resistance (By similarity). Involved in inflammatory arthri [...] "},{"id":"ENSMUSP00000019503","abundance":1.1,"rank":10684,"name":"Gdpd2","annotation":"Glycerophosphoinositol inositolphosphodiesterase GDPD2; Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton."},{"id":"ENSMUSP00000030674","abundance":1.1,"rank":10685,"name":"Sytl1","annotation":"Synaptotagmin-like protein 1; Binds phosphatidylinositol 3,4,5-trisphosphate (By similarity). May play a role in vesicle trafficking. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes."},{"id":"ENSMUSP00000110608","abundance":1.1,"rank":10686,"name":"Elf4","annotation":"ETS-related transcription factor Elf-4; Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in  [...] "},{"id":"ENSMUSP00000027897","abundance":1.1,"rank":10687,"name":"Smyd2","annotation":"N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily."},{"id":"ENSMUSP00000024711","abundance":1.1,"rank":10688,"name":"Adgrf4","annotation":"Adhesion G protein-coupled receptor F4; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily."},{"id":"ENSMUSP00000032518","abundance":1.1,"rank":10689,"name":"Clec2h","annotation":"C-type lectin domain family 2 member H; Lectin-type cell surface receptor."},{"id":"ENSMUSP00000101508","abundance":1.1,"rank":10690,"name":"Zfp683","annotation":"Tissue-resident T-cell transcription regulator protein ZNF683; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T-cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long- term establishment of adaptive and innate tissue-resident lymphocyte T- cell types in non-lymphoid or [...] "},{"id":"ENSMUSP00000021552","abundance":1.1,"rank":10691,"name":"Zfp36l1","annotation":"mRNA decay activator protein ZFP36L1; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'- untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylating complex and components of the cytoplasmic RNA decay machinery to the bound ARE- containing mRNAs, and hence pr [...] "},{"id":"ENSMUSP00000067008","abundance":1.1,"rank":10692,"name":"Ang5","annotation":"Angiogenin-3; May promote vascularization of normal and malignant tissues (By similarity). Has low ribonuclease activity (in vitro)."},{"id":"ENSMUSP00000002902","abundance":1.1,"rank":10693,"name":"Qtrt1","annotation":"Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] "},{"id":"ENSMUSP00000074764","abundance":1.1,"rank":10694,"name":"St8sia5","annotation":"Alpha-2,8-sialyltransferase 8E; May be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b and GT3 from GD1a, GT1b, GM1b and GD3 respectively."},{"id":"ENSMUSP00000021890","abundance":1.1,"rank":10695,"name":"Cts6","annotation":"Cathepsin-6; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000146333","abundance":1.1,"rank":10696,"name":"Olfr1437","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000102982","abundance":1.1,"rank":10697,"name":"Megf9","annotation":"Multiple epidermal growth factor-like domains protein 9."},{"id":"ENSMUSP00000061764","abundance":1.1,"rank":10698,"name":"Olfr620","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000153712","abundance":1.1,"rank":10699,"name":"Vmn1r5","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000059199","abundance":1.1,"rank":10700,"name":"Ifne","annotation":"Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral, including HSV-2, and bacterial, including Chlamydia muridarum, genital infections; Belongs to the alpha/beta interferon family."},{"id":"ENSMUSP00000028003","abundance":1.1,"rank":10701,"name":"Lmx1a","annotation":"LIM homeobox transcription factor 1-alpha; Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae."},{"id":"ENSMUSP00000005073","abundance":1.1,"rank":10702,"name":"Zp3","annotation":"Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation; Belongs to the ZP domain family. ZPC subfamily."},{"id":"ENSMUSP00000128509","abundance":1.1,"rank":10703,"name":"Trim13","annotation":"E3 ubiquitin-protein ligase TRIM13; Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER- associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress- induced autophagy, and [...] "},{"id":"ENSMUSP00000130710","abundance":1.09,"rank":10704,"name":"Tjap1","annotation":"Tight junction-associated protein 1."},{"id":"ENSMUSP00000139759","abundance":1.09,"rank":10705,"name":"Auts2","annotation":"Autism susceptibility gene 2 protein homolog; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylati [...] "},{"id":"ENSMUSP00000027580","abundance":1.09,"rank":10706,"name":"Slc35f5","annotation":"Solute carrier family 35 member F5; Putative solute transporter; Belongs to the SLC35F solute transporter family."},{"id":"ENSMUSP00000110872","abundance":1.09,"rank":10707,"name":"Napepld","annotation":"N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D; Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of these bioactive fatty acid ethanolamides (FAEs), including anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors. As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting col [...] "},{"id":"ENSMUSP00000151183","abundance":1.09,"rank":10708,"name":"Olfr1156","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000036220","abundance":1.09,"rank":10709,"name":"Armh4","annotation":"Armadillo-like helical domain-containing protein 4."},{"id":"ENSMUSP00000055073","abundance":1.09,"rank":10710,"name":"Irak2","annotation":"Interleukin-1 receptor-associated kinase-like 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization."},{"id":"ENSMUSP00000103103","abundance":1.09,"rank":10711,"name":"Rapgefl1","annotation":"Rap guanine nucleotide exchange factor-like 1; Probable guanine nucleotide exchange factor (GEF)."},{"id":"ENSMUSP00000003451","abundance":1.09,"rank":10712,"name":"Rnd1","annotation":"Rho-related GTP-binding protein Rho6; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (By similarity); Belongs to the small GTPase superfamily. Rho family."},{"id":"ENSMUSP00000150812","abundance":1.09,"rank":10713,"name":"Olfr1220","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000091713","abundance":1.09,"rank":10714,"name":"Tsku","annotation":"Tsukushin."},{"id":"ENSMUSP00000065118","abundance":1.09,"rank":10715,"name":"4930503L19Rik","annotation":"Lung adenoma susceptibility protein 2; Might play a role in cell proliferation."},{"id":"ENSMUSP00000017946","abundance":1.09,"rank":10716,"name":"Retreg3","annotation":"Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth. Belongs to the RETREG family."},{"id":"ENSMUSP00000047016","abundance":1.09,"rank":10717,"name":"Neurod6","annotation":"Neurogenic differentiation factor 6; Activates E box-dependent transcription in collaboration with TCF3/E47. May be a trans-acting factor involved in the development and maintenance of the mammalian nervous system. Transactivates the promoter of its own gene."},{"id":"ENSMUSP00000069212","abundance":1.09,"rank":10718,"name":"Inka2","annotation":"PAK4-inhibitor INKA2; Inhibitor of the serine/threonine-protein kinase PAK4. Acts by binding PAK4 in a substrate-like manner, inhibiting the protein kinase activity."},{"id":"ENSMUSP00000028378","abundance":1.09,"rank":10719,"name":"Galnt3","annotation":"Polypeptide N-acetylgalactosaminyltransferase 3; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Glycosylates FGF23 (By similarity). Probably glycosylates fibronectin in vivo. May be involved in phosphate homeostasis."},{"id":"ENSMUSP00000023601","abundance":1.09,"rank":10720,"name":"St6gal1","annotation":"Beta-galactoside alpha-2,6-sialyltransferase 1; Transfers sialic acid from CMP-sialic acid to galactose- containing acceptor substrates."},{"id":"ENSMUSP00000094045","abundance":1.09,"rank":10721,"name":"Armcx5","annotation":"Armadillo repeat-containing X-linked protein 5."},{"id":"ENSMUSP00000064333","abundance":1.09,"rank":10722,"name":"Wnt11","annotation":"Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters; Belongs to the Wnt family."},{"id":"ENSMUSP00000041263","abundance":1.09,"rank":10723,"name":"Usp22","annotation":"Ubiquitin carboxyl-terminal hydrolase 22; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression (By similarity); Belongs to the peptidase C19 family. UBP8 subfamily."},{"id":"ENSMUSP00000062109","abundance":1.09,"rank":10724,"name":"Otop2","annotation":"Proton channel OTOP2; Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes."},{"id":"ENSMUSP00000044682","abundance":1.09,"rank":10725,"name":"Psenen","annotation":"Gamma-secretase subunit PEN-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). The gamma- secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity."},{"id":"ENSMUSP00000096457","abundance":1.09,"rank":10726,"name":"Kcnu1","annotation":"Potassium channel subfamily U member 1; Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). Represents the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. Belongs to the potassium channel family. Calcium-activ [...] "},{"id":"ENSMUSP00000146925","abundance":1.09,"rank":10727,"name":"Olfr1434","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000084523","abundance":1.09,"rank":10728,"name":"Abca12","annotation":"ATP-binding cassette, sub-family A (ABC1), member 12."},{"id":"ENSMUSP00000111535","abundance":1.09,"rank":10729,"name":"Mpp7","annotation":"MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity); Belongs to the MAGUK family."},{"id":"ENSMUSP00000143344","abundance":1.09,"rank":10730,"name":"Celf3","annotation":"CUGBP Elav-like family member 3; RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA (By similarity)."},{"id":"ENSMUSP00000043792","abundance":1.09,"rank":10731,"name":"Camta2","annotation":"Calmodulin-binding transcription activator 2; Transcription activator. May act as tumor suppressor (By similarity); Belongs to the CAMTA family."},{"id":"ENSMUSP00000093960","abundance":1.09,"rank":10732,"name":"Eml3","annotation":"Echinoderm microtubule-associated protein-like 3; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family."},{"id":"ENSMUSP00000102639","abundance":1.09,"rank":10733,"name":"Arhgap27","annotation":"Rho GTPase-activating protein 27; Rho GTPase-activating protein which may be involved in clathrin-mediated endocytosis. GTPase activators for the Rho-type GTPases act by converting them to an inactive GDP-bound state. Has activity toward CDC42 and RAC1 (By similarity)."},{"id":"ENSMUSP00000016640","abundance":1.09,"rank":10734,"name":"Cd274","annotation":"Programmed cell death 1 ligand 1; Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10) ; Belongs to the immunoglobulin superfamily. BTN/MOG family."},{"id":"ENSMUSP00000095758","abundance":1.09,"rank":10735,"name":"Olfr688","annotation":"Olfactory receptor 688; Odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000108160","abundance":1.09,"rank":10736,"name":"Cd163","annotation":"Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion  [...] "},{"id":"ENSMUSP00000147824","abundance":1.09,"rank":10737,"name":"Gm8773","annotation":"Predicted gene 8773."},{"id":"ENSMUSP00000094931","abundance":1.08,"rank":10738,"name":"Olfr120","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000068178","abundance":1.08,"rank":10739,"name":"Rims3","annotation":"Regulating synaptic membrane exocytosis protein 3; Regulates synaptic membrane exocytosis."},{"id":"ENSMUSP00000032956","abundance":1.08,"rank":10740,"name":"Sgf29","annotation":"SAGA-associated factor 29; Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me. Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival."},{"id":"ENSMUSP00000072330","abundance":1.08,"rank":10741,"name":"Myod1","annotation":"Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins."},{"id":"ENSMUSP00000029865","abundance":1.08,"rank":10742,"name":"Trp53inp1","annotation":"Tumor protein p53-inducible nuclear protein 1; Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxyg [...] "},{"id":"ENSMUSP00000139359","abundance":1.08,"rank":10743,"name":"Kif7","annotation":"Kinesin-like protein KIF7; Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU- dependent and -independent mechanisms. Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional acti [...] "},{"id":"ENSMUSP00000021411","abundance":1.08,"rank":10744,"name":"Prorp","annotation":"Mitochondrial ribonuclease P catalytic subunit; Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP, which cleaves tRNA molecules in their 5'-ends. The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends."},{"id":"ENSMUSP00000127395","abundance":1.08,"rank":10745,"name":"Pogk","annotation":"Pogo transposable element with KRAB domain."},{"id":"ENSMUSP00000085440","abundance":1.08,"rank":10746,"name":"Adgrf3","annotation":"Adhesion G-protein coupled receptor F3; Orphan receptor."},{"id":"ENSMUSP00000096541","abundance":1.08,"rank":10747,"name":"Spc24","annotation":"Kinetochore protein Spc24; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Belongs to the SPC24 family."},{"id":"ENSMUSP00000057020","abundance":1.08,"rank":10748,"name":"Fam187b","annotation":"Protein FAM187B; Belongs to the FAM187 family."},{"id":"ENSMUSP00000081532","abundance":1.08,"rank":10749,"name":"Gm11232","annotation":"Predicted gene 11232."},{"id":"ENSMUSP00000021715","abundance":1.08,"rank":10750,"name":"Xrcc3","annotation":"DNA repair protein XRCC3; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the f [...] "},{"id":"ENSMUSP00000151331","abundance":1.08,"rank":10751,"name":"Olfr1426","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000070012","abundance":1.08,"rank":10752,"name":"Uty","annotation":"Histone demethylase UTY; Male-specific histone demethylase that catalyzes trimethylated 'Lys-27' (H3K27me3) demethylation in histone H3. Has relatively low KDM activity."},{"id":"ENSMUSP00000113582","abundance":1.08,"rank":10753,"name":"Slc5a4b","annotation":"Solute carrier family 5 (neutral amino acid transporters, system A), member 4b; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family."},{"id":"ENSMUSP00000045025","abundance":1.08,"rank":10754,"name":"Tgtp2","annotation":"T-cell-specific guanine nucleotide triphosphate-binding protein 1; Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii. During avirulent type II T. gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol. Not recruited to virulent type I T. gondii PV membrane. May confer an antiviral state for vesicular stomatitis virus."},{"id":"ENSMUSP00000069914","abundance":1.08,"rank":10755,"name":"Tgtp1","annotation":"T cell specific GTPase 1."},{"id":"ENSMUSP00000134672","abundance":1.08,"rank":10756,"name":"Pla2g6","annotation":"85/88 kDa calcium-independent phospholipase A2; Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide- induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose- stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2- induced chemotaxis through regulation of F-actin polymerization at the pseudopods (By [...] "},{"id":"ENSMUSP00000104833","abundance":1.08,"rank":10757,"name":"Gm5431","annotation":"Predicted gene 5431."},{"id":"ENSMUSP00000074347","abundance":1.08,"rank":10758,"name":"Mtfmt","annotation":"Methionyl-tRNA formyltransferase, mitochondrial; Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism (By similarity); Belongs to the Fmt family."},{"id":"ENSMUSP00000096991","abundance":1.08,"rank":10759,"name":"Hps6","annotation":"Hermansky-Pudlak syndrome 6 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules (By similarity). Acts as cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning."},{"id":"ENSMUSP00000001172","abundance":1.08,"rank":10760,"name":"Ankrd39","annotation":"Ankyrin repeat domain-containing protein 39; Belongs to the ANKRD39 family."},{"id":"ENSMUSP00000131120","abundance":1.08,"rank":10761,"name":"4930433I11Rik","annotation":"RIKEN cDNA 4930433I11 gene."},{"id":"ENSMUSP00000060073","abundance":1.08,"rank":10762,"name":"Jak3","annotation":"Tyrosine-protein kinase JAK3; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails o [...] "},{"id":"ENSMUSP00000034843","abundance":1.08,"rank":10763,"name":"Ireb2","annotation":"Iron-responsive element-binding protein 2; RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA."},{"id":"ENSMUSP00000035616","abundance":1.08,"rank":10764,"name":"Slc24a1","annotation":"Solute carrier family 24 (Sodium/potassium/calcium exchanger), member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family."},{"id":"ENSMUSP00000028020","abundance":1.08,"rank":10765,"name":"Myoc","annotation":"Myocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] "},{"id":"ENSMUSP00000108408","abundance":1.08,"rank":10766,"name":"Gm15114","annotation":"Predicted gene 15114."},{"id":"ENSMUSP00000054292","abundance":1.08,"rank":10767,"name":"Adam29","annotation":"Disintegrin and metalloproteinase domain-containing protein 29; May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein (By similarity)."},{"id":"ENSMUSP00000136503","abundance":1.08,"rank":10768,"name":"Slc30a6","annotation":"Zinc transporter 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment."},{"id":"ENSMUSP00000147633","abundance":1.08,"rank":10769,"name":"Ppp1r3b","annotation":"Protein phosphatase 1 regulatory subunit 3B; Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated gl [...] "},{"id":"ENSMUSP00000037557","abundance":1.07,"rank":10770,"name":"Mzt1","annotation":"Mitotic-spindle organizing protein 1; Required for gamma-tubulin complex recruitment to the centrosome."},{"id":"ENSMUSP00000067779","abundance":1.07,"rank":10771,"name":"Afap1","annotation":"Actin filament-associated protein 1; Can cross-link actin filaments into both network and bundle structures. May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton (By similarity)."},{"id":"ENSMUSP00000037596","abundance":1.07,"rank":10772,"name":"Cep78","annotation":"Centrosomal protein of 78 kDa; May be required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles. May play a role in cilium biogenesis."},{"id":"ENSMUSP00000063352","abundance":1.07,"rank":10773,"name":"Slc2a9","annotation":"Solute carrier family 2, facilitated glucose transporter member 9; Urate transporter, which may play a role in the urate reabsorption by proximal tubules. Does not transport glucose, fructose or galactose (By similarity). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family."},{"id":"ENSMUSP00000127995","abundance":1.07,"rank":10774,"name":"Blm","annotation":"Bloom syndrome protein homolog; ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction. Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Belongs to the helica [...] "},{"id":"ENSMUSP00000082928","abundance":1.07,"rank":10775,"name":"Sdk1","annotation":"Protein sidekick-1; Adhesion molecule that promotes lamina-specific synaptic connections in the retina. Expressed in specific subsets of interneurons and retinal ganglion cells (RGCs) and promotes synaptic connectivity via homophilic interactions."},{"id":"ENSMUSP00000113911","abundance":1.07,"rank":10776,"name":"Amz1","annotation":"Archaemetzincin-1; Zinc metalloprotease. Exhibits aminopeptidase activity against neurogranin in vitro. Does not hydrolyze angiotensin-2 (By similarity)."},{"id":"ENSMUSP00000049898","abundance":1.07,"rank":10777,"name":"Nkx2-6","annotation":"Homeobox protein Nkx-2.6; Acts as a transcriptional activator (By similarity). In conjunction with NKX2-5, may play a role in both pharyngeal and cardiac embryonic development."},{"id":"ENSMUSP00000039879","abundance":1.07,"rank":10778,"name":"Ctrc","annotation":"Chymotrypsin-C; Has chymotrypsin-type protease activity and hypocalcemic activity; Belongs to the peptidase S1 family. Elastase subfamily."},{"id":"ENSMUSP00000032815","abundance":1.07,"rank":10779,"name":"Nfkbib","annotation":"NF-kappa-B inhibitor beta; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation."},{"id":"ENSMUSP00000115729","abundance":1.07,"rank":10780,"name":"AU022252","annotation":"Uncharacterized protein C1orf50 homolog."},{"id":"ENSMUSP00000068972","abundance":1.07,"rank":10781,"name":"Ccdc172","annotation":"Coiled-coil domain-containing protein 172."},{"id":"ENSMUSP00000108771","abundance":1.07,"rank":10782,"name":"Mtmr14","annotation":"Myotubularin-related protein 14; Lipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3."},{"id":"ENSMUSP00000139524","abundance":1.07,"rank":10783,"name":"Fam227a","annotation":"Family with sequence similarity 227, member A."},{"id":"ENSMUSP00000144692","abundance":1.07,"rank":10784,"name":"Vsig10l","annotation":"V-set and immunoglobulin domain-containing protein 10-like."},{"id":"ENSMUSP00000046297","abundance":1.07,"rank":10785,"name":"Cdnf","annotation":"Cerebral dopamine neurotrophic factor; Trophic factor for dopamine neurons. Prevents the 6- hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons. When administered after 6-OHDA-lesioning, restores the dopaminergic function and prevents the degeneration of dopaminergic neurons in substantia nigra (By similarity); Belongs to the ARMET family."},{"id":"ENSMUSP00000004156","abundance":1.07,"rank":10786,"name":"Map3k11","annotation":"Mitogen-activated protein kinase kinase kinase 11; Activates the JUN N-terminal pathway. Required for serum- stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen- stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle (By similarity); Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase  [...] "},{"id":"ENSMUSP00000048900","abundance":1.07,"rank":10787,"name":"Igsf3","annotation":"Immunoglobulin superfamily member 3."},{"id":"ENSMUSP00000040262","abundance":1.07,"rank":10788,"name":"Tecta","annotation":"Alpha-tectorin; One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals."},{"id":"ENSMUSP00000035112","abundance":1.07,"rank":10789,"name":"Nktr","annotation":"NK-tumor recognition protein; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumor-recognition complex involved in the function of NK cells."},{"id":"ENSMUSP00000149209","abundance":1.07,"rank":10790,"name":"Olfr578","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000077873","abundance":1.07,"rank":10791,"name":"Fcgr4","annotation":"Low affinity immunoglobulin gamma Fc region receptor IV; Receptor for the Fc region of immunoglobulin gamma. Also acts as a receptor for the Fc region of immunoglobulin epsilon. Binds with intermediate affinity to both IgG2a and IgG2b. Can bind to IgG2a and IgG2b monomers. Does not display binding to IgG1 or IgG3. Mediates neutrophil activation by IgG complexes redundantly with Fcgr3. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to I [...] "},{"id":"ENSMUSP00000127746","abundance":1.07,"rank":10792,"name":"Zbtb3","annotation":"Zinc finger and BTB domain-containing protein 3; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000131331","abundance":1.07,"rank":10793,"name":"Gmeb1","annotation":"Glucocorticoid modulatory element-binding protein 1; Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity)."},{"id":"ENSMUSP00000148664","abundance":1.07,"rank":10794,"name":"Gm9918","annotation":"Predicted gene 9918."},{"id":"ENSMUSP00000150352","abundance":1.07,"rank":10795,"name":"Olfr1014","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000124022","abundance":1.07,"rank":10796,"name":"Pappa2","annotation":"Pappalysin 2."},{"id":"ENSMUSP00000086710","abundance":1.07,"rank":10797,"name":"Tafa4","annotation":"Chemokine-like protein TAFA-4; Modulates injury-induced and chemical pain hypersensitivity. Ligand of FPR1, can chemoattract macrophages, promote phagocytosis and increase ROS release."},{"id":"ENSMUSP00000112157","abundance":1.07,"rank":10798,"name":"Cyth3","annotation":"Cytohesin-3; Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization."},{"id":"ENSMUSP00000062120","abundance":1.07,"rank":10799,"name":"9530077C05Rik","annotation":"Uncharacterized protein KIAA0895."},{"id":"ENSMUSP00000115718","abundance":1.07,"rank":10800,"name":"Als2cl","annotation":"ALS2 C-terminal-like protein; Acts as a guanine nucleotide exchange factor (GEF) for Rab5 GTPase. Regulates the ALS2-mediated endosome dynamics (By similarity)."},{"id":"ENSMUSP00000037034","abundance":1.07,"rank":10801,"name":"Fam53c","annotation":"Protein FAM53C; Belongs to the FAM53 family."},{"id":"ENSMUSP00000099572","abundance":1.07,"rank":10802,"name":"Rtn4rl1","annotation":"Reticulon-4 receptor-like 1; Cell surface receptor that plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in res [...] "},{"id":"ENSMUSP00000103679","abundance":1.07,"rank":10803,"name":"Il18r1","annotation":"Interleukin-18 receptor 1; Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B. Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (By similarity). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3."},{"id":"ENSMUSP00000049380","abundance":1.07,"rank":10804,"name":"Adgrf1","annotation":"Adhesion G-protein coupled receptor F1; Orphan receptor."},{"id":"ENSMUSP00000112498","abundance":1.07,"rank":10805,"name":"Zdhhc13","annotation":"Palmitoyltransferase ZDHHC13; Palmitoyltransferase for HTT and GAD2. May play a role in Mg(2+) transport. Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily."},{"id":"ENSMUSP00000020959","abundance":1.07,"rank":10806,"name":"Rnaseh1","annotation":"Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II; Belongs to the RNase H family."},{"id":"ENSMUSP00000150463","abundance":1.07,"rank":10807,"name":"Cx3cr1","annotation":"CX3C chemokine receptor 1; Receptor for the CX3C chemokine fractalkine (CX3CL1); binds to CX3CL1 and mediates both its adhesive and migratory functions."},{"id":"ENSMUSP00000031534","abundance":1.07,"rank":10808,"name":"Mad1l1","annotation":"Mitotic spindle assembly checkpoint protein MAD1; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding."},{"id":"ENSMUSP00000036916","abundance":1.07,"rank":10809,"name":"Slc26a9","annotation":"Solute carrier family 26 member 9; DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport. Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion. Inhibited by ammonium and thiosulfate."},{"id":"ENSMUSP00000104979","abundance":1.07,"rank":10810,"name":"Lrrc36","annotation":"Leucine-rich repeat-containing protein 36."},{"id":"ENSMUSP00000129230","abundance":1.07,"rank":10811,"name":"Alx1","annotation":"ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival. May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity)."},{"id":"ENSMUSP00000034896","abundance":1.07,"rank":10812,"name":"Mto1","annotation":"Protein MTO1 homolog, mitochondrial; Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. Belongs to the MnmG family."},{"id":"ENSMUSP00000058042","abundance":1.07,"rank":10813,"name":"Rab11fip1","annotation":"Rab11 family-interacting protein 1; A Rab11 effector protein involved in the endosomal recycling process. Also involved in controlling membrane trafficking along the phagocytic pathway and phagocytosis (By similarity)."},{"id":"ENSMUSP00000027185","abundance":1.06,"rank":10814,"name":"Stradb","annotation":"STE20-related kinase adapter protein beta; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity)."},{"id":"ENSMUSP00000022666","abundance":1.06,"rank":10815,"name":"Klhl1","annotation":"Kelch-like protein 1; May play a role in organizing the actin cytoskeleton of the brain cells."},{"id":"ENSMUSP00000143072","abundance":1.06,"rank":10816,"name":"5730480H06Rik","annotation":"PACRG-like protein."},{"id":"ENSMUSP00000077135","abundance":1.06,"rank":10817,"name":"Gpbar1","annotation":"G-protein coupled bile acid receptor 1; Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids (By similarity). Involved in bile acid promoted GLP1R secretion."},{"id":"ENSMUSP00000062006","abundance":1.06,"rank":10818,"name":"Fam3b","annotation":"Protein FAM3B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner; Belongs to the FAM3 family."},{"id":"ENSMUSP00000133510","abundance":1.06,"rank":10819,"name":"Ly6g6c","annotation":"Lymphocyte antigen 6 complex locus protein G6c."},{"id":"ENSMUSP00000020896","abundance":1.06,"rank":10820,"name":"Tspan13","annotation":"Tetraspanin-13."},{"id":"ENSMUSP00000038749","abundance":1.06,"rank":10821,"name":"Pde3a","annotation":"cGMP-inhibited 3',5'-cyclic phosphodiesterase A; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Involved in oocyte maturation."},{"id":"ENSMUSP00000102501","abundance":1.06,"rank":10822,"name":"Olfr613","annotation":"Olfactory receptor 613."},{"id":"ENSMUSP00000081903","abundance":1.06,"rank":10823,"name":"Xntrpc","annotation":"Short transient receptor potential channel 2; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. May also be activated by intracellular calcium store depletion. Plays a role in mediating responsivity to pheromones that elicit aggressive and mating behaviors. Required for response to the Esp1 pheromone which enhances female sexual receptive behavior and to the Esp22 pheromone which inhibits adult male mating behavior."},{"id":"ENSMUSP00000078251","abundance":1.06,"rank":10824,"name":"Cyp3a57","annotation":"Cytochrome P450, family 3, subfamily a, polypeptide 57."},{"id":"ENSMUSP00000049619","abundance":1.06,"rank":10825,"name":"Gpat2","annotation":"Glycerol-3-phosphate acyltransferase 2, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Required for primary processing step during piRNA biosynthesis. Molecular mechanisms by which it promotes piRNA biosynthesis are unclear and do not involve its acyltransferase activity."},{"id":"ENSMUSP00000052599","abundance":1.06,"rank":10826,"name":"Ly6k","annotation":"Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. May play a role in cell growth (By similarity)."},{"id":"ENSMUSP00000070551","abundance":1.06,"rank":10827,"name":"Tmem119","annotation":"Transmembrane protein 119; Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4 which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation."},{"id":"ENSMUSP00000044751","abundance":1.06,"rank":10828,"name":"Tmem258","annotation":"Transmembrane protein 258; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are requ [...] "},{"id":"ENSMUSP00000050014","abundance":1.06,"rank":10829,"name":"Rilpl1","annotation":"RILP-like protein 1; Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus (By similarity). Competes with SIAH1 for binding GAPDH (By similarity). Does not regulate lysosomal morphology and distribution (By similarity). Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (By similarity). Belongs to the RIL [...] "},{"id":"ENSMUSP00000097113","abundance":1.06,"rank":10830,"name":"Hcn2","annotation":"Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current."},{"id":"ENSMUSP00000086342","abundance":1.06,"rank":10831,"name":"Bpifb3","annotation":"BPI fold-containing family B member 3; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity); Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family."},{"id":"ENSMUSP00000019443","abundance":1.06,"rank":10832,"name":"Rnf31","annotation":"E3 ubiquitin-protein ligase RNF31; E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (By similarity). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. Recruited to the TNF-R1 signaling complex (TNF-RSC) fol [...] "},{"id":"ENSMUSP00000076043","abundance":1.06,"rank":10833,"name":"Tas2r106","annotation":"Taste receptor type 2 member 106; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000049973","abundance":1.06,"rank":10834,"name":"Haus3","annotation":"HAUS augmin-like complex subunit 3; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex; Belongs to the HAUS3 family."},{"id":"ENSMUSP00000086816","abundance":1.06,"rank":10835,"name":"Sacs","annotation":"Sacsin; Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins."},{"id":"ENSMUSP00000112052","abundance":1.06,"rank":10836,"name":"Xylt2","annotation":"Xylosyltransferase 2; Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein (By similarity). Belongs to the glycosyltransferase 14 family. XylT subfamily."},{"id":"ENSMUSP00000034385","abundance":1.06,"rank":10837,"name":"Has3","annotation":"Hyaluronan synthase 3; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction; Belongs to the NodC/HAS family."},{"id":"ENSMUSP00000056276","abundance":1.06,"rank":10838,"name":"Aldh3b1","annotation":"Aldehyde dehydrogenase family 3 member B1; Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde (By similarity). Low activity towards acetaldehyde and 3,4- dihydroxyphenylacetaldehyde (By similarity). May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor (By similarity). May have a protective role against the cytotoxicity induced by lipid peroxidation (By similarity)."},{"id":"ENSMUSP00000020102","abundance":1.06,"rank":10839,"name":"Slc17a8","annotation":"Vesicular glutamate transporter 3; Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily."},{"id":"ENSMUSP00000009772","abundance":1.06,"rank":10840,"name":"Tex15","annotation":"Testis-expressed protein 15; Required during spermatogenesis for normal chromosome synapsis and meiotic recombination in germ cells. Necessary for formation of DMC1 and RAD51 foci on meiotic chromosomes, suggesting a specific role in DNA double-stranded break repair."},{"id":"ENSMUSP00000046683","abundance":1.06,"rank":10841,"name":"Bpifb5","annotation":"BPI fold-containing family B, member 5."},{"id":"ENSMUSP00000097811","abundance":1.06,"rank":10842,"name":"Cd300ld4","annotation":"CD300 molecule like family member D4."},{"id":"ENSMUSP00000090116","abundance":1.06,"rank":10843,"name":"Cd300ld3","annotation":"CMRF35-like molecule 3; Acts as an activating receptor inducing cytokine production in mast cells. Can act as a positive regulator of TLR9 signaling in macrophages, leading to enhanced production of proinflammatory cytokines."},{"id":"ENSMUSP00000097810","abundance":1.06,"rank":10844,"name":"Cd300ld5","annotation":"CD300 molecule-like family member D4."},{"id":"ENSMUSP00000102476","abundance":1.06,"rank":10845,"name":"Olfr631","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000012186","abundance":1.06,"rank":10846,"name":"4930579F01Rik","annotation":"RIKEN cDNA 4930579F01 gene."},{"id":"ENSMUSP00000030947","abundance":1.06,"rank":10847,"name":"Mxra8","annotation":"Matrix remodeling-associated protein 8; Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3. Mediates heterophilic cell-cell interactions in vitro. Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38. Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes. Stimulates formation of primary cilia in chondrocytes. Enhances expression of genes involved in the hedge [...] "},{"id":"ENSMUSP00000147605","abundance":1.06,"rank":10848,"name":"Olfr374","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000038569","abundance":1.05,"rank":10849,"name":"Lrrc17","annotation":"Leucine-rich repeat-containing protein 17; Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors."},{"id":"ENSMUSP00000082543","abundance":1.05,"rank":10850,"name":"Izumo2","annotation":"Izumo sperm-egg fusion protein 2."},{"id":"ENSMUSP00000025404","abundance":1.05,"rank":10851,"name":"Cidea","annotation":"Cell death activator CIDE-A; Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IG [...] "},{"id":"ENSMUSP00000138290","abundance":1.05,"rank":10852,"name":"Dclre1a","annotation":"DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons."},{"id":"ENSMUSP00000031805","abundance":1.05,"rank":10853,"name":"Avl9","annotation":"Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family."},{"id":"ENSMUSP00000102164","abundance":1.05,"rank":10854,"name":"Grin2c","annotation":"Glutamate receptor ionotropic, NMDA 2C; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. Plays a role in regulating the balance between excitatory and inhibitory activity of pyrami [...] "},{"id":"ENSMUSP00000038051","abundance":1.05,"rank":10855,"name":"Gabrb3","annotation":"Gamma-aminobutyric acid receptor subunit beta-3; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA- gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The a [...] "},{"id":"ENSMUSP00000074514","abundance":1.05,"rank":10856,"name":"Olfr836","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000126540","abundance":1.05,"rank":10857,"name":"Ubtfl1","annotation":"Upstream-binding factor 1-like protein 1; Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development."},{"id":"ENSMUSP00000101658","abundance":1.05,"rank":10858,"name":"Fam229a","annotation":"Protein FAM229A; Belongs to the FAM229 family."},{"id":"ENSMUSP00000074025","abundance":1.05,"rank":10859,"name":"Efcab14","annotation":"EF-hand calcium-binding domain-containing protein 14."},{"id":"ENSMUSP00000044757","abundance":1.05,"rank":10860,"name":"Tcam1","annotation":"Testicular cell adhesion molecule 1."},{"id":"ENSMUSP00000044020","abundance":1.05,"rank":10861,"name":"2610008E11Rik","annotation":"RIKEN cDNA 2610008E11 gene."},{"id":"ENSMUSP00000035257","abundance":1.05,"rank":10862,"name":"Slc30a8","annotation":"Zinc transporter 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells (By similarity)."},{"id":"ENSMUSP00000027053","abundance":1.05,"rank":10863,"name":"Rdh10","annotation":"Retinol dehydrogenase 10; Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (By similarity). Required for normal embryonic development; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000022528","abundance":1.05,"rank":10864,"name":"Pinx1","annotation":"PIN2/TERF1-interacting telomerase inhibitor 1; Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor (By similarity)."},{"id":"ENSMUSP00000108651","abundance":1.05,"rank":10865,"name":"Dipk2a","annotation":"Divergent protein kinase domain 2A; May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PI3-kinase signaling cascade. Belongs to the DIPK family."},{"id":"ENSMUSP00000056121","abundance":1.05,"rank":10866,"name":"Wwc2","annotation":"Protein WWC2; Belongs to the WWC family."},{"id":"ENSMUSP00000021379","abundance":1.05,"rank":10867,"name":"Gemin2","annotation":"Gem-associated protein 2; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...] "},{"id":"ENSMUSP00000104996","abundance":1.05,"rank":10868,"name":"Ttll8","annotation":"Protein monoglycylase TTLL8; Monoglycylase which modifies both tubulin and non-tubulin proteins, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues of target proteins. Monoglycylates tubulin, with a preference for alpha-tubulin toward beta-tubulin. Has the ability to modify non-tubulin proteins such as ANP32A, ANP32B, SET and NCL. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction."},{"id":"ENSMUSP00000050424","abundance":1.05,"rank":10869,"name":"Mettl21a","annotation":"Protein N-lysine methyltransferase METTL21A; Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8 (By similarity)."},{"id":"ENSMUSP00000041173","abundance":1.05,"rank":10870,"name":"Nfkbiz","annotation":"NF-kappa-B inhibitor zeta; Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promote [...] "},{"id":"ENSMUSP00000072276","abundance":1.05,"rank":10871,"name":"Lhb","annotation":"Lutropin subunit beta; Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids."},{"id":"ENSMUSP00000136329","abundance":1.05,"rank":10872,"name":"Birc6","annotation":"Baculoviral IAP repeat-containing protein 6; Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also [...] "},{"id":"ENSMUSP00000031851","abundance":1.05,"rank":10873,"name":"Tmem213","annotation":"Transmembrane protein 213."},{"id":"ENSMUSP00000053986","abundance":1.05,"rank":10874,"name":"Lpar4","annotation":"Lysophosphatidic acid receptor 4; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1- oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1- alkenyl-LPA (By similarity)."},{"id":"ENSMUSP00000019992","abundance":1.05,"rank":10875,"name":"Lama4","annotation":"Laminin subunit alpha-4; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."},{"id":"ENSMUSP00000092020","abundance":1.05,"rank":10876,"name":"Gpr157","annotation":"G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol-calcium second messenger. Belongs to the G-protein coupled receptor 2 family."},{"id":"ENSMUSP00000029478","abundance":1.05,"rank":10877,"name":"Slc25a54","annotation":"Solute carrier family 25, member 54; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000093315","abundance":1.05,"rank":10878,"name":"Lmod3","annotation":"Leiomodin-3; Essential for the organization of sarcomeric actin thin filaments in skeletal muscle. Increases the rate of actin polymerization (By similarity). Belongs to the tropomodulin family."},{"id":"ENSMUSP00000034411","abundance":1.05,"rank":10879,"name":"Med17","annotation":"Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000110592","abundance":1.05,"rank":10880,"name":"Proser2","annotation":"Proline and serine-rich protein 2."},{"id":"ENSMUSP00000064494","abundance":1.05,"rank":10881,"name":"Slc51b","annotation":"Organic solute transporter subunit beta; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities."},{"id":"ENSMUSP00000072534","abundance":1.05,"rank":10882,"name":"Dohh","annotation":"Deoxyhypusine hydroxylase; Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L- lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF- 5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function."},{"id":"ENSMUSP00000085695","abundance":1.05,"rank":10883,"name":"Atn1","annotation":"Atrophin-1; Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats (By similarity). Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation."},{"id":"ENSMUSP00000149115","abundance":1.04,"rank":10884,"name":"Olfr806","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000079588","abundance":1.04,"rank":10885,"name":"Tpbpb","annotation":"Trophoblast-specific protein beta."},{"id":"ENSMUSP00000026662","abundance":1.04,"rank":10886,"name":"Cbx2","annotation":"Chromobox protein homolog 2; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (By similarity). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Plays a role in the lineage differentiation of the [...] "},{"id":"ENSMUSP00000046536","abundance":1.04,"rank":10887,"name":"Ap5m1","annotation":"AP-5 complex subunit mu-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport."},{"id":"ENSMUSP00000150774","abundance":1.04,"rank":10888,"name":"Olfr484","annotation":"Olfactory receptor 484; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000067364","abundance":1.04,"rank":10889,"name":"Rnf222","annotation":"RING finger protein 222."},{"id":"ENSMUSP00000132050","abundance":1.04,"rank":10890,"name":"Vrtn","annotation":"Vertnin; Belongs to the vertnin family."},{"id":"ENSMUSP00000151154","abundance":1.04,"rank":10891,"name":"Olfr1425","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000124033","abundance":1.04,"rank":10892,"name":"Wdr41","annotation":"WD repeat-containing protein 41; Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity."},{"id":"ENSMUSP00000131438","abundance":1.04,"rank":10893,"name":"Syce2","annotation":"Synaptonemal complex central element protein 2; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination."},{"id":"ENSMUSP00000108306","abundance":1.04,"rank":10894,"name":"Cecr2","annotation":"Cat eye syndrome critical region protein 2 homolog; Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI- type complex (By similarity). It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes. In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (By simi [...] "},{"id":"ENSMUSP00000037651","abundance":1.04,"rank":10895,"name":"BC016579","annotation":"TPA-induced transmembrane protein homolog."},{"id":"ENSMUSP00000038938","abundance":1.04,"rank":10896,"name":"Ctdp1","annotation":"RNA polymerase II subunit A C-terminal domain phosphatase; Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M- phase-promoting factor (MPF)/CDK1 inactivation (By similarity)."},{"id":"ENSMUSP00000046900","abundance":1.04,"rank":10897,"name":"Lat2","annotation":"Linker for activation of T-cells family member 2; Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2."},{"id":"ENSMUSP00000085531","abundance":1.04,"rank":10898,"name":"Obp1a","annotation":"Odorant-binding protein 1a; Binds the chemical odorant 2-isobutyl-3-methoxypyrazine."},{"id":"ENSMUSP00000035516","abundance":1.04,"rank":10899,"name":"Ostm1","annotation":"Osteopetrosis-associated transmembrane protein 1; Required for osteoclast and melanocyte maturation and function."},{"id":"ENSMUSP00000099301","abundance":1.04,"rank":10900,"name":"Selenos","annotation":"Selenoprotein S; Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination (By similarity)."},{"id":"ENSMUSP00000031072","abundance":1.04,"rank":10901,"name":"Anapc4","annotation":"Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)."},{"id":"ENSMUSP00000059757","abundance":1.04,"rank":10902,"name":"Polq","annotation":"DNA polymerase theta; DNA polymerase that promotes microhomology-mediated end- joining (MMEJ), an alternative non-homologous end-joining (NHEJ) machinery triggered in response to double-strand breaks in DNA. MMEJ is an error-prone repair pathway that produces deletions of sequences from the strand being repaired and promotes genomic rearrangements, such as telomere fusions, some of them leading to cellular transformation. POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends. POLQ-mediated MMEJ may be required to promote [...] "},{"id":"ENSMUSP00000052507","abundance":1.04,"rank":10903,"name":"Frrs1l","annotation":"DOMON domain-containing protein FRRS1L; Important modulator of glutamate signaling pathway."},{"id":"ENSMUSP00000097938","abundance":1.04,"rank":10904,"name":"Fam187a","annotation":"Ig-like V-type domain-containing protein FAM187A."},{"id":"ENSMUSP00000093155","abundance":1.04,"rank":10905,"name":"Ccdc78","annotation":"Coiled-coil domain-containing protein 78; Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome (By similarity); Belongs to the CCDC78 family."},{"id":"ENSMUSP00000046129","abundance":1.04,"rank":10906,"name":"Akap9","annotation":"A-kinase anchor protein 9; Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus. Required for microtubule nucleation at the cis-side of the Golgi apparatus. Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase. In complex with PDE4DIP isoform 2/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. In comple [...] "},{"id":"ENSMUSP00000033522","abundance":1.04,"rank":10907,"name":"3830417A13Rik","annotation":"RIKEN cDNA 3830417A13 gene."},{"id":"ENSMUSP00000114652","abundance":1.04,"rank":10908,"name":"Stox1","annotation":"Storkhead-box protein 1; Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (By similarity). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway. Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (By similarity). Induces phosphorylation of MAPT/tau (By similarity)."},{"id":"ENSMUSP00000059389","abundance":1.04,"rank":10909,"name":"Arhgap30","annotation":"Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42."},{"id":"ENSMUSP00000021769","abundance":1.04,"rank":10910,"name":"Slc17a4","annotation":"Probable small intestine urate exporter; Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro) (By similarity). Belongs to the major facilitator superfamily. Sodium/anion cotransporter family."},{"id":"ENSMUSP00000097885","abundance":1.04,"rank":10911,"name":"Bmyc","annotation":"Protein B-Myc; Seems to act as an inhibitor of cellular proliferation."},{"id":"ENSMUSP00000025314","abundance":1.04,"rank":10912,"name":"Dele1","annotation":"DAP3-binding cell death enhancer 1; Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation."},{"id":"ENSMUSP00000106232","abundance":1.04,"rank":10913,"name":"Wdr76","annotation":"WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC."},{"id":"ENSMUSP00000061808","abundance":1.04,"rank":10914,"name":"Gdpgp1","annotation":"GDP-D-glucose phosphorylase 1; Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells."},{"id":"ENSMUSP00000098969","abundance":1.04,"rank":10915,"name":"Tmem176a","annotation":"Transmembrane protein 176A."},{"id":"ENSMUSP00000137355","abundance":1.04,"rank":10916,"name":"Gm3500","annotation":"Predicted gene 3500."},{"id":"ENSMUSP00000135906","abundance":1.04,"rank":10917,"name":"Gm3373","annotation":"Predicted gene 3373."},{"id":"ENSMUSP00000029676","abundance":1.04,"rank":10918,"name":"Adam15","annotation":"Disintegrin and metalloproteinase domain-containing protein 15; Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. [...] "},{"id":"ENSMUSP00000129363","abundance":1.03,"rank":10919,"name":"Klf3","annotation":"Krueppel-like factor 3; Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000110738","abundance":1.03,"rank":10920,"name":"Ei24","annotation":"Etoposide-induced protein 2.4; Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity)."},{"id":"ENSMUSP00000095487","abundance":1.03,"rank":10921,"name":"Zscan20","annotation":"Zinc finger and SCAN domain-containing protein 20; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000088254","abundance":1.03,"rank":10922,"name":"Pde4dip","annotation":"Myomegalin; Functions as an anchor sequestering components of the cAMP- dependent pathway to Golgi and/or centrosomes (By similarity)."},{"id":"ENSMUSP00000113785","abundance":1.03,"rank":10923,"name":"Inava","annotation":"Innate immunity activator protein; Expressed in peripheral macrophages and intestinal myeloid- derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion (By similarity). In the int [...] "},{"id":"ENSMUSP00000041756","abundance":1.03,"rank":10924,"name":"Arl5a","annotation":"ADP-ribosylation factor-like protein 5A; Lacks ADP-ribosylation enhancing activity."},{"id":"ENSMUSP00000155089","abundance":1.03,"rank":10925,"name":"Kansl2","annotation":"KAT8 regulatory NSL complex subunit 2; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription."},{"id":"ENSMUSP00000060363","abundance":1.03,"rank":10926,"name":"2510002D24Rik","annotation":"UPF0545 protein C22orf39 homolog; Belongs to the UPF0545 family."},{"id":"ENSMUSP00000103951","abundance":1.03,"rank":10927,"name":"Dll3","annotation":"Delta-like protein 3; Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm."},{"id":"ENSMUSP00000000808","abundance":1.03,"rank":10928,"name":"Il12rb1","annotation":"Interleukin-12 receptor subunit beta-1; Functions as an interleukin receptor which binds interleukin- 12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade; Belongs to the type I cytokine receptor family. Type 2 subfamily."},{"id":"ENSMUSP00000097972","abundance":1.03,"rank":10929,"name":"B3glct","annotation":"Beta-1,3-glucosyltransferase; O-glucosyltransferase that transfers glucose toward fucose with a beta-1,3 linkage. Specifically glucosylates O-linked fucosylglycan on TSP type-1 domains of proteins, thereby contributing to elongation of O-fucosylglycan (By similarity); Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000096982","abundance":1.03,"rank":10930,"name":"Brd9","annotation":"Bromodomain-containing protein 9; Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner."},{"id":"ENSMUSP00000078674","abundance":1.03,"rank":10931,"name":"Ccdc192","annotation":"Coiled-coil domain-containing 192."},{"id":"ENSMUSP00000087709","abundance":1.03,"rank":10932,"name":"Slc37a3","annotation":"Sugar phosphate exchanger 3."},{"id":"ENSMUSP00000053000","abundance":1.03,"rank":10933,"name":"4930402K13Rik","annotation":"RIKEN cDNA 4930402K13 gene."},{"id":"ENSMUSP00000137472","abundance":1.03,"rank":10934,"name":"Ube2u","annotation":"Ubiquitin-conjugating enzyme E2U (putative)."},{"id":"ENSMUSP00000138328","abundance":1.03,"rank":10935,"name":"Raet1d","annotation":"Retinoic acid early-inducible protein 1-delta; Acts as a ligand for KLRK1."},{"id":"ENSMUSP00000026831","abundance":1.03,"rank":10936,"name":"Rhbdl1","annotation":"Rhomboid-related protein 1; May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors."},{"id":"ENSMUSP00000047385","abundance":1.03,"rank":10937,"name":"Piwil2","annotation":"Piwi-like protein 2; Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells. Its presence in oocytes suggests that it may participate in similar functions during oogenesis in females. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes compos [...] "},{"id":"ENSMUSP00000040121","abundance":1.03,"rank":10938,"name":"Hoxb7","annotation":"Homeobox protein Hox-B7; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family."},{"id":"ENSMUSP00000089708","abundance":1.03,"rank":10939,"name":"Stat6","annotation":"Signal transducer and transcription activator 6; Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling; Belongs to the transcription factor STAT family."},{"id":"ENSMUSP00000076827","abundance":1.03,"rank":10940,"name":"Cyp4f37","annotation":"Cytochrome P450, family 4, subfamily f, polypeptide 37; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000107510","abundance":1.03,"rank":10941,"name":"Dclk3","annotation":"Serine/threonine-protein kinase DCLK3."},{"id":"ENSMUSP00000052017","abundance":1.03,"rank":10942,"name":"Ust","annotation":"Uronyl 2-sulfotransferase; Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues. Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity toward glucuronyl residues of chondroitin sulfate. Has no activity toward desulfated N- resulfated heparin (By similarity)."},{"id":"ENSMUSP00000141924","abundance":1.03,"rank":10943,"name":"Nsun6","annotation":"tRNA (cytosine(72)-C(5))-methyltransferase NSUN6; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in tRNA(Thr)(TGT) and tRNA(Cys)(GCA). In vitro also methylates tRNA(Thr)(AGT). Methylation requires, in the acceptor stem region, the presence of the 3'-CCA terminus, the target site C72, the discriminator base U73, and the second and third base pairs (2:71 and 3:70) in the tRNA substrates."},{"id":"ENSMUSP00000057270","abundance":1.03,"rank":10944,"name":"Champ1","annotation":"Chromosome alignment-maintaining phosphoprotein 1; Required for proper alignment of chromosomes at metaphase and their accurate segregation during mitosis. Involved in the maintenance of spindle microtubules attachment to the kinetochore during sister chromatid biorientation. May recruit CENPE and CENPF to the kinetochore (By similarity)."},{"id":"ENSMUSP00000100577","abundance":1.03,"rank":10945,"name":"Ubl4b","annotation":"Ubiquitin-like protein 4B."},{"id":"ENSMUSP00000103122","abundance":1.03,"rank":10946,"name":"Gon4l","annotation":"GON-4-like protein; Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis."},{"id":"ENSMUSP00000049440","abundance":1.03,"rank":10947,"name":"Arpin","annotation":"Arpin; Regulates actin polymerization by inhibiting the actin- nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity); Belongs to the Arpin family."},{"id":"ENSMUSP00000032414","abundance":1.03,"rank":10948,"name":"Ttll3","annotation":"Tubulin monoglycylase TTLL3; Monoglycylase which modifies alpha- and beta-tubulin, generating side chains of glycine on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin. Involved in the side-chain initiation step of the glycylation reaction by adding a single glycine chain to generate monoglycine side chains. Not involved in elongation step of the polyglycylation reaction."},{"id":"ENSMUSP00000023611","abundance":1.03,"rank":10949,"name":"Adamts5","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 5; Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan. Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle de [...] "},{"id":"ENSMUSP00000096197","abundance":1.03,"rank":10950,"name":"Foxb1","annotation":"Forkhead box protein B1."},{"id":"ENSMUSP00000146694","abundance":1.03,"rank":10951,"name":"Tnfsf13b","annotation":"Tumor necrosis factor ligand superfamily member 13b, membrane form; Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T- cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B- cells and the B-cell response."},{"id":"ENSMUSP00000031080","abundance":1.03,"rank":10952,"name":"Fam114a1","annotation":"Protein Noxp20; May play a role in neuronal cell development; Belongs to the FAM114 family."},{"id":"ENSMUSP00000071859","abundance":1.03,"rank":10953,"name":"Trpv4","annotation":"Transient receptor potential cation channel subfamily V member 4; Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism (By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes (By similarity).  [...] "},{"id":"ENSMUSP00000156411","abundance":1.03,"rank":10954,"name":"Crisp2","annotation":"Cysteine-rich secretory protein 2; May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation. Belongs to the CRISP family."},{"id":"ENSMUSP00000021937","abundance":1.03,"rank":10955,"name":"Zfp346","annotation":"Zinc finger protein 346; Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (By similarity). May bind to specific miRNA hairpins (By similarity)."},{"id":"ENSMUSP00000149493","abundance":1.03,"rank":10956,"name":"Olfr805","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000046544","abundance":1.03,"rank":10957,"name":"Sgsm1","annotation":"Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family."},{"id":"ENSMUSP00000049650","abundance":1.03,"rank":10958,"name":"Zfp759","annotation":"Regulator of sex-limitation candidate 8."},{"id":"ENSMUSP00000158926","abundance":1.03,"rank":10959,"name":"Zswim6","annotation":"Zinc finger SWIM domain-containing protein 6; involved in nervous system development, important for striatal morphology and motor regulation."},{"id":"ENSMUSP00000017544","abundance":1.02,"rank":10960,"name":"Stac2","annotation":"SH3 and cysteine-rich domain-containing protein 2; Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C."},{"id":"ENSMUSP00000002292","abundance":1.02,"rank":10961,"name":"Rmnd5a","annotation":"E3 ubiquitin-protein ligase RMND5A; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1."},{"id":"ENSMUSP00000045637","abundance":1.02,"rank":10962,"name":"Rims4","annotation":"Regulating synaptic membrane exocytosis protein 4; Regulates synaptic membrane exocytosis."},{"id":"ENSMUSP00000041145","abundance":1.02,"rank":10963,"name":"Ibtk","annotation":"Inhibitor of Bruton tyrosine kinase; Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription (By similarity)."},{"id":"ENSMUSP00000107771","abundance":1.02,"rank":10964,"name":"Oasl1","annotation":"2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family."},{"id":"ENSMUSP00000088336","abundance":1.02,"rank":10965,"name":"Rapgef4","annotation":"Rap guanine nucleotide exchange factor 4; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2."},{"id":"ENSMUSP00000035433","abundance":1.02,"rank":10966,"name":"Btbd16","annotation":"BTB/POZ domain-containing protein 16."},{"id":"ENSMUSP00000004051","abundance":1.02,"rank":10967,"name":"Hlf","annotation":"Hepatic leukemia factor; Belongs to the bZIP family. PAR subfamily."},{"id":"ENSMUSP00000068332","abundance":1.02,"rank":10968,"name":"Tas2r102","annotation":"Taste receptor type 2 member 102; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000124091","abundance":1.02,"rank":10969,"name":"Vgll2","annotation":"Transcription cofactor vestigial-like protein 2; May act as a specific coactivator for the mammalian TEFs. May play a role in the development of skeletal muscles."},{"id":"ENSMUSP00000066396","abundance":1.02,"rank":10970,"name":"Prr5","annotation":"Proline-rich protein 5; Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 [...] "},{"id":"ENSMUSP00000038152","abundance":1.02,"rank":10971,"name":"Tex43","annotation":"Testis-expressed protein 43."},{"id":"ENSMUSP00000029355","abundance":1.02,"rank":10972,"name":"Ppm1l","annotation":"Protein phosphatase 1L; Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. Belongs to the PP2C family."},{"id":"ENSMUSP00000104459","abundance":1.02,"rank":10973,"name":"Helz2","annotation":"Helicase with zinc finger domain 2; Helicase that acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA."},{"id":"ENSMUSP00000149577","abundance":1.02,"rank":10974,"name":"Olfr606","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000038041","abundance":1.02,"rank":10975,"name":"Abcc10","annotation":"Multidrug resistance-associated protein 7; ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion."},{"id":"ENSMUSP00000021922","abundance":1.02,"rank":10976,"name":"Msx2","annotation":"Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter; Belongs to the Msh homeobox family."},{"id":"ENSMUSP00000099400","abundance":1.02,"rank":10977,"name":"Zhx3","annotation":"Zinc fingers and homeoboxes protein 3; Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA; Belongs to the ZHX family."},{"id":"ENSMUSP00000084342","abundance":1.02,"rank":10978,"name":"Cdkl5","annotation":"Cyclin-dependent kinase-like 5; Mediates phosphorylation of MECP2. May regulate ciliogenesis."},{"id":"ENSMUSP00000011391","abundance":1.02,"rank":10979,"name":"Prss45","annotation":"Inactive serine protease 45; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000029164","abundance":1.02,"rank":10980,"name":"Sla2","annotation":"Src-like-adapter 2; Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins."},{"id":"ENSMUSP00000116898","abundance":1.02,"rank":10981,"name":"Ganc","annotation":"Neutral alpha-glucosidase C; Has alpha-glucosidase activity; Belongs to the glycosyl hydrolase 31 family."},{"id":"ENSMUSP00000041395","abundance":1.02,"rank":10982,"name":"Ppm1k","annotation":"Protein phosphatase 1K, mitochondrial; Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. Belongs to the PP2C family."},{"id":"ENSMUSP00000080550","abundance":1.02,"rank":10983,"name":"Nell1","annotation":"Protein kinase C-binding protein NELL1; Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization."},{"id":"ENSMUSP00000048862","abundance":1.02,"rank":10984,"name":"Srd5a2","annotation":"3-oxo-5-alpha-steroid 4-dehydrogenase 2; Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology."},{"id":"ENSMUSP00000047949","abundance":1.02,"rank":10985,"name":"Hoxd4","annotation":"Homeobox protein Hox-D4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily."},{"id":"ENSMUSP00000013807","abundance":1.02,"rank":10986,"name":"Pten","annotation":"Phosphatase and tensin homolog; In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (By similarity). Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4- diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5- tetrakisphosphate with order of subst [...] "},{"id":"ENSMUSP00000020478","abundance":1.02,"rank":10987,"name":"Hcfc2","annotation":"Host cell factor 2."},{"id":"ENSMUSP00000141331","abundance":1.02,"rank":10988,"name":"Lin9","annotation":"Protein lin-9 homolog; Acts as a tumor suppressor. Inhibits DNA synthesis. Its ability to inhibit oncogenic transformation is mediated through its association with RB1. Plays a role in the expression of genes required for the G1/S transition (By similarity); Belongs to the lin-9 family."},{"id":"ENSMUSP00000006301","abundance":1.02,"rank":10989,"name":"Lrwd1","annotation":"Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post- replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation (By similarity). Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stabi [...] "},{"id":"ENSMUSP00000026480","abundance":1.02,"rank":10990,"name":"Ttc4","annotation":"Tetratricopeptide repeat protein 4; May act as a co-chaperone for HSP90AB1 (By similarity). Belongs to the TTC4 family."},{"id":"ENSMUSP00000024816","abundance":1.02,"rank":10991,"name":"Cmtr1","annotation":"Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1; S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG- capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway."},{"id":"ENSMUSP00000108788","abundance":1.02,"rank":10992,"name":"Nxf7","annotation":"Nuclear mRNA export factor 7."},{"id":"ENSMUSP00000059871","abundance":1.02,"rank":10993,"name":"Lgsn","annotation":"Lengsin; May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity."},{"id":"ENSMUSP00000100927","abundance":1.02,"rank":10994,"name":"Nr2c1","annotation":"Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental r [...] "},{"id":"ENSMUSP00000047018","abundance":1.02,"rank":10995,"name":"Dxo","annotation":"Decapping and exoribonuclease protein; Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'- pyrophosphohydrolase activity by  [...] "},{"id":"ENSMUSP00000091388","abundance":1.01,"rank":10996,"name":"Olfr143","annotation":"Olfactory receptor 143; Odorant receptor."},{"id":"ENSMUSP00000023846","abundance":1.01,"rank":10997,"name":"Lrrc71","annotation":"Leucine-rich repeat-containing protein 71."},{"id":"ENSMUSP00000055449","abundance":1.01,"rank":10998,"name":"Rp1l1","annotation":"Retinitis pigmentosa 1-like 1 protein; Required for the differentiation of photoreceptor cells. Plays a role in the organization of outer segment of rod and cone photoreceptors."},{"id":"ENSMUSP00000125409","abundance":1.01,"rank":10999,"name":"Gm7247","annotation":"Predicted gene 7247."},{"id":"ENSMUSP00000153662","abundance":1.01,"rank":11000,"name":"Ptprm","annotation":"Receptor-type tyrosine-protein phosphatase mu; Involved in cell-cell adhesion through homophilic interactions. May play a key role in signal transduction and growth control."},{"id":"ENSMUSP00000132190","abundance":1.01,"rank":11001,"name":"Phykpl","annotation":"5-phosphohydroxy-L-lysine phospho-lyase; Catalyzes the pyridoxal-phosphate-dependent breakdown of 5- phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family."},{"id":"ENSMUSP00000103434","abundance":1.01,"rank":11002,"name":"Frmpd1","annotation":"FERM and PDZ domain-containing protein 1; Stabilizes membrane-bound GPSM1, and thereby promotes its interaction with GNAI1."},{"id":"ENSMUSP00000071270","abundance":1.01,"rank":11003,"name":"Prr23a2","annotation":"Proline-rich 23A, member 2."},{"id":"ENSMUSP00000092467","abundance":1.01,"rank":11004,"name":"Gm1673","annotation":"Neuropeptide-like protein C4orf48 homolog."},{"id":"ENSMUSP00000127603","abundance":1.01,"rank":11005,"name":"Zc3h12c","annotation":"Probable ribonuclease ZC3H12C; May function as RNase and regulate the levels of target RNA species."},{"id":"ENSMUSP00000147606","abundance":1.01,"rank":11006,"name":"Zfp42","annotation":"Zinc finger protein 42; Involved in the reprogramming of X-chromosome inactivation during the acquisition of pluripotency. Required for efficient elongation of TSIX, a non-coding RNA antisense to XIST. Binds DXPas34 enhancer within the TSIX promoter. Involved in ES cell self-renewal."},{"id":"ENSMUSP00000023497","abundance":1.01,"rank":11007,"name":"Lmln","annotation":"Leishmanolysin-like peptidase; Metalloprotease."},{"id":"ENSMUSP00000033081","abundance":1.01,"rank":11008,"name":"Fbxl19","annotation":"F-box/LRR-repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (By similarity). Binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (By similarity)."},{"id":"ENSMUSP00000029541","abundance":1.01,"rank":11009,"name":"Slc27a3","annotation":"Solute carrier family 27 member 3; Has acyl-CoA ligase activity for long-chain and very-long- chain fatty acids. Does not exhibit fatty acid transport activity."},{"id":"ENSMUSP00000127811","abundance":1.01,"rank":11010,"name":"Gm3591","annotation":"Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3, pseudogene."},{"id":"ENSMUSP00000003705","abundance":1.01,"rank":11011,"name":"Aven","annotation":"Cell death regulator Aven; Protects against apoptosis mediated by Apaf-1."},{"id":"ENSMUSP00000112266","abundance":1.01,"rank":11012,"name":"Brms1","annotation":"Breast cancer metastasis-suppressor 1 homolog; Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis (By similarity)."},{"id":"ENSMUSP00000026126","abundance":1.01,"rank":11013,"name":"Ints4","annotation":"Integrator complex subunit 4; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex."},{"id":"ENSMUSP00000037137","abundance":1.01,"rank":11014,"name":"Orai2","annotation":"Protein orai-2; Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1."},{"id":"ENSMUSP00000132118","abundance":1.01,"rank":11015,"name":"Gm8108","annotation":"Predicted gene 8108."},{"id":"ENSMUSP00000047358","abundance":1.01,"rank":11016,"name":"Mc3r","annotation":"Melanocortin receptor 3; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain."},{"id":"ENSMUSP00000092853","abundance":1.01,"rank":11017,"name":"Samd1","annotation":"Atherin; May play a role in atherogenesis by immobilizing LDL in the atherial wall."},{"id":"ENSMUSP00000112584","abundance":1.01,"rank":11018,"name":"Oas1c","annotation":"Inactive 2'-5' oligoadenylate synthetase 1C; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA; Belongs to the 2-5A synthase family."},{"id":"ENSMUSP00000068590","abundance":1.01,"rank":11019,"name":"B3gntl1","annotation":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1; Putative glycosyltransferase; Belongs to the glycosyltransferase 2 family."},{"id":"ENSMUSP00000040367","abundance":1.01,"rank":11020,"name":"Trpm4","annotation":"Transient receptor potential cation channel subfamily M member 4; Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating [...] "},{"id":"ENSMUSP00000139911","abundance":1.01,"rank":11021,"name":"Tmem81","annotation":"Transmembrane protein 81."},{"id":"ENSMUSP00000075377","abundance":1.01,"rank":11022,"name":"Cand2","annotation":"Cullin-associated NEDD8-dissociated protein 2; Probable assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes; Belongs to the CAND family."},{"id":"ENSMUSP00000149405","abundance":1.01,"rank":11023,"name":"Olfr168","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000030285","abundance":1.01,"rank":11024,"name":"Calr4","annotation":"Calreticulin."},{"id":"ENSMUSP00000039966","abundance":1.01,"rank":11025,"name":"Ripor1","annotation":"Rho family-interacting cell polarization regulator 1; Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation. Belongs to the RIPOR family."},{"id":"ENSMUSP00000058204","abundance":1.01,"rank":11026,"name":"Clrn2","annotation":"Clrn2 protein."},{"id":"ENSMUSP00000062110","abundance":1,"rank":11027,"name":"Tapt1","annotation":"Transmembrane anterior posterior transformation protein 1; Plays a role in primary cilia formation (By similarity). May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). May be involved in cartilage and bone development (By similarity). May play a role in the differentiation of cranial neural crest cells (By similarity). Belongs to the TAPT1 family."},{"id":"ENSMUSP00000054105","abundance":1,"rank":11028,"name":"Hepacam","annotation":"Hepatocyte cell adhesion molecule; Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (By similarity)."},{"id":"ENSMUSP00000017384","abundance":1,"rank":11029,"name":"Casc3","annotation":"Protein CASC3; Required for pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs th [...] "},{"id":"ENSMUSP00000138618","abundance":1,"rank":11030,"name":"Cacng8","annotation":"Voltage-dependent calcium channel gamma-8 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inac [...] "},{"id":"ENSMUSP00000010188","abundance":1,"rank":11031,"name":"Zmynd10","annotation":"Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins (By similarity); Belongs to the ZMYND10 family."},{"id":"ENSMUSP00000078426","abundance":1,"rank":11032,"name":"Wdr90","annotation":"WD repeat-containing protein 90; Required for efficient primary cilium formation."},{"id":"ENSMUSP00000123953","abundance":1,"rank":11033,"name":"Zfp27","annotation":"Zinc finger protein 27; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000030216","abundance":1,"rank":11034,"name":"Saxo1","annotation":"Stabilizer of axonemal microtubules 1."},{"id":"ENSMUSP00000075966","abundance":1,"rank":11035,"name":"Plppr1","annotation":"Phospholipid phosphatase-related protein type 1; Belongs to the PA-phosphatase related phosphoesterase family."},{"id":"ENSMUSP00000106869","abundance":1,"rank":11036,"name":"Ttc17","annotation":"Tetratricopeptide repeat protein 17; Plays a role in primary ciliogenesis by modulating actin polymerization; Belongs to the TTC17 family."},{"id":"ENSMUSP00000022767","abundance":1,"rank":11037,"name":"Mettl3","annotation":"N6-adenosine-methyltransferase subunit METTL3; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing. In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core (By similarity). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some  [...] "},{"id":"ENSMUSP00000152501","abundance":1,"rank":11038,"name":"Zfyve1","annotation":"Zinc finger FYVE domain-containing protein 1."},{"id":"ENSMUSP00000105354","abundance":1,"rank":11039,"name":"Zfp429","annotation":"Regulator of sex-limitation 2."},{"id":"ENSMUSP00000033201","abundance":1,"rank":11040,"name":"Anks4b","annotation":"Ankyrin repeat and SAM domain-containing protein 4B; As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (By similarity). May play a role in cellular response to endoplasmic reticulum stress."},{"id":"ENSMUSP00000140219","abundance":1,"rank":11041,"name":"Kirrel3","annotation":"Processed kin of IRRE-like protein 3; Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopo [...] "},{"id":"ENSMUSP00000154068","abundance":1,"rank":11042,"name":"Vmn1r38","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000062642","abundance":1,"rank":11043,"name":"Fam76b","annotation":"Protein FAM76B."},{"id":"ENSMUSP00000028017","abundance":1,"rank":11044,"name":"Eef1aknmt","annotation":"eEF1A lysine and N-terminal methyltransferase; Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation. Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N- terminal residue 'Gly-2'. Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55'."},{"id":"ENSMUSP00000072868","abundance":1,"rank":11045,"name":"Zfp746","annotation":"Zinc finger protein 746; Transcription repressor that specifically binds to the 5'- TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000025831","abundance":1,"rank":11046,"name":"Dock8","annotation":"Dedicator of cytokinesis protein 8; Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lyti [...] "},{"id":"ENSMUSP00000022275","abundance":1,"rank":11047,"name":"Ankrd55","annotation":"Ankyrin repeat domain-containing protein 55."},{"id":"ENSMUSP00000032955","abundance":0.999,"rank":11048,"name":"Klk7","annotation":"Kallikrein-7; May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines."},{"id":"ENSMUSP00000113793","abundance":0.999,"rank":11049,"name":"Furin","annotation":"Furin; Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif. Mediates processing of TGFB1, an essential step in TGF-beta-1 activation. Belongs to the peptidase S8 family. Furin subfamily."},{"id":"ENSMUSP00000033927","abundance":0.999,"rank":11050,"name":"Eri1","annotation":"3'-5' exoribonuclease 1; RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Binds with high affinity to the 3' side of the stem-loop structure and to the downstream cleavage product (DCP) of histone pr [...] "},{"id":"ENSMUSP00000004994","abundance":0.998,"rank":11051,"name":"Pax3","annotation":"Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (By similarity); Belongs to the paired homeobox family."},{"id":"ENSMUSP00000150241","abundance":0.998,"rank":11052,"name":"Olfr914","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000030305","abundance":0.998,"rank":11053,"name":"Cyp2j13","annotation":"Cytochrome P450, family 2, subfamily j, polypeptide 13; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000025680","abundance":0.998,"rank":11054,"name":"Lipf","annotation":"Gastric triacylglycerol lipase; Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000129533","abundance":0.997,"rank":11055,"name":"Gm3252","annotation":"Predicted gene 3252."},{"id":"ENSMUSP00000124028","abundance":0.997,"rank":11056,"name":"4933434E20Rik","annotation":"Uncharacterized protein C1orf43 homolog."},{"id":"ENSMUSP00000149866","abundance":0.997,"rank":11057,"name":"Olfr641","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000043710","abundance":0.997,"rank":11058,"name":"Dip2a","annotation":"Disco-interacting protein 2 homolog A; May provide positional cues for axon pathfinding and patterning in the central nervous system; Belongs to the DIP2 family."},{"id":"ENSMUSP00000036347","abundance":0.997,"rank":11059,"name":"Shcbp1l","annotation":"Testicular spindle-associated protein SHCBP1L; Testis-specific spindle-associated factor that plays a role in spermatogenesis. In association with HSPA2, participates in the maintenance of spindle integrity during meiosis in male germ cells."},{"id":"ENSMUSP00000022433","abundance":0.996,"rank":11060,"name":"Dnah12","annotation":"Dynein heavy chain 12, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)."},{"id":"ENSMUSP00000090082","abundance":0.996,"rank":11061,"name":"Ccdc153","annotation":"Coiled-coil domain-containing protein 153; Belongs to the UPF0610 family."},{"id":"ENSMUSP00000102613","abundance":0.996,"rank":11062,"name":"Sppl2c","annotation":"Signal peptide peptidase-like 2C; Intramembrane-cleaving aspartic protease (I-CLiP) that may be able to cleave type II membrane signal peptides in the hydrophobic plane of the membrane."},{"id":"ENSMUSP00000066696","abundance":0.996,"rank":11063,"name":"Nab1","annotation":"NGFI-A-binding protein 1; Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2."},{"id":"ENSMUSP00000108555","abundance":0.995,"rank":11064,"name":"Cntf","annotation":"Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy."},{"id":"ENSMUSP00000151837","abundance":0.995,"rank":11065,"name":"Bcl9l","annotation":"B-cell CLL/lymphoma 9-like protein; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1. Belongs to the BCL9 family."},{"id":"ENSMUSP00000105419","abundance":0.995,"rank":11066,"name":"Plagl2","annotation":"Pleiomorphic adenoma gene-like 2."},{"id":"ENSMUSP00000019117","abundance":0.995,"rank":11067,"name":"Hoxb1","annotation":"Homeobox protein Hox-B1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures."},{"id":"ENSMUSP00000038366","abundance":0.995,"rank":11068,"name":"Scube3","annotation":"Signal peptide, CUB and EGF-like domain-containing protein 3; Binds to TGFBR2 and activates TGFB signaling."},{"id":"ENSMUSP00000138585","abundance":0.994,"rank":11069,"name":"Arhgap12","annotation":"Rho GTPase-activating protein 12; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state."},{"id":"ENSMUSP00000042642","abundance":0.993,"rank":11070,"name":"Il22ra2","annotation":"Interleukin-22 receptor subunit alpha-2; Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses."},{"id":"ENSMUSP00000026259","abundance":0.993,"rank":11071,"name":"Pitx3","annotation":"Pituitary homeobox 3; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep pro [...] "},{"id":"ENSMUSP00000088740","abundance":0.993,"rank":11072,"name":"Arl15","annotation":"ADP-ribosylation factor-like protein 15; Belongs to the small GTPase superfamily. Arf family."},{"id":"ENSMUSP00000060233","abundance":0.993,"rank":11073,"name":"Ppp1r37","annotation":"Protein phosphatase 1 regulatory subunit 37; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes; Belongs to the PPP1R37 family."},{"id":"ENSMUSP00000002850","abundance":0.992,"rank":11074,"name":"Abcc6","annotation":"Multidrug resistance-associated protein 6; May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily."},{"id":"ENSMUSP00000020434","abundance":0.991,"rank":11075,"name":"Glipr1l2","annotation":"GLIPR1-like protein 2; Belongs to the CRISP family."},{"id":"ENSMUSP00000021605","abundance":0.991,"rank":11076,"name":"Trip11","annotation":"Thyroid hormone receptor interactor 11."},{"id":"ENSMUSP00000154007","abundance":0.991,"rank":11077,"name":"Vmn1r193","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000078551","abundance":0.99,"rank":11078,"name":"Etv5","annotation":"ETS translocation variant 5; Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'; Belongs to the ETS family."},{"id":"ENSMUSP00000054938","abundance":0.99,"rank":11079,"name":"Tnfrsf26","annotation":"Tumor necrosis factor receptor superfamily member 26."},{"id":"ENSMUSP00000105797","abundance":0.99,"rank":11080,"name":"Zhx1","annotation":"Zinc fingers and homeoboxes protein 1; Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins (By similarity)."},{"id":"ENSMUSP00000125960","abundance":0.989,"rank":11081,"name":"Mcm3ap","annotation":"Germinal-center associated nuclear protein; As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations ; Belongs to the SAC3 family."},{"id":"ENSMUSP00000092522","abundance":0.989,"rank":11082,"name":"Tmem237","annotation":"Transmembrane protein 237; Component of the transition zone in primary cilia. Required for ciliogenesis; Belongs to the TMEM237 family."},{"id":"ENSMUSP00000091471","abundance":0.989,"rank":11083,"name":"Fbxo47","annotation":"F-box only protein 47; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation."},{"id":"ENSMUSP00000084467","abundance":0.989,"rank":11084,"name":"Nfxl1","annotation":"Nuclear transcription factor, X-box-binding-like 1."},{"id":"ENSMUSP00000140177","abundance":0.989,"rank":11085,"name":"Rhof","annotation":"Rho-related GTP-binding protein RhoF; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology (By similarity)."},{"id":"ENSMUSP00000082941","abundance":0.989,"rank":11086,"name":"Card11","annotation":"Caspase recruitment domain-containing protein 11; Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway (By similarity)."},{"id":"ENSMUSP00000078361","abundance":0.988,"rank":11087,"name":"Lin28b","annotation":"Protein lin-28 homolog B; Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA. Does not act on pri-miR21. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recr [...] "},{"id":"ENSMUSP00000103017","abundance":0.988,"rank":11088,"name":"Mesp2","annotation":"Mesoderm posterior protein 2."},{"id":"ENSMUSP00000092845","abundance":0.988,"rank":11089,"name":"Fbxw9","annotation":"F-box and WD-40 domain protein 9."},{"id":"ENSMUSP00000118984","abundance":0.988,"rank":11090,"name":"Ankrd33b","annotation":"Ankyrin repeat domain-containing protein 33B."},{"id":"ENSMUSP00000112820","abundance":0.987,"rank":11091,"name":"Rlim","annotation":"E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase that acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation [...] "},{"id":"ENSMUSP00000043587","abundance":0.987,"rank":11092,"name":"Meox2","annotation":"Homeobox protein MOX-2; Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle."},{"id":"ENSMUSP00000034437","abundance":0.987,"rank":11093,"name":"Wdr59","annotation":"GATOR complex protein WDR59; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. Belongs to the WD repeat WDR59 family."},{"id":"ENSMUSP00000032125","abundance":0.986,"rank":11094,"name":"Bmp10","annotation":"Bone morphogenetic protein 10; Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines (By similarity). Belongs to the TGF-be [...] "},{"id":"ENSMUSP00000010298","abundance":0.986,"rank":11095,"name":"Spire2","annotation":"Protein spire homolog 2; Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during oocyte meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin  [...] "},{"id":"ENSMUSP00000050275","abundance":0.986,"rank":11096,"name":"Gas2l1","annotation":"GAS2-like protein 1; Seems to be involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity); Belongs to the GAS2 family."},{"id":"ENSMUSP00000149208","abundance":0.986,"rank":11097,"name":"Olfr1420","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000099462","abundance":0.986,"rank":11098,"name":"Tnfrsf18","annotation":"Tumor necrosis factor receptor superfamily member 18; Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity)."},{"id":"ENSMUSP00000126092","abundance":0.985,"rank":11099,"name":"Pik3c2a","annotation":"Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion dow [...] "},{"id":"ENSMUSP00000036285","abundance":0.985,"rank":11100,"name":"Smad6","annotation":"Mothers against decapentaplegic homolog 6; Binds to regulatory elements in target promoter regions (By similarity). May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding (By similarity). Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes."},{"id":"ENSMUSP00000053112","abundance":0.985,"rank":11101,"name":"Odf3b","annotation":"Outer dense fiber protein 3B; Belongs to the ODF3 family."},{"id":"ENSMUSP00000025418","abundance":0.985,"rank":11102,"name":"Psmg2","annotation":"Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization (By similarity)."},{"id":"ENSMUSP00000048540","abundance":0.985,"rank":11103,"name":"Scgb2b2","annotation":"Secretoglobin family 2B member 2; Belongs to the secretoglobin family."},{"id":"ENSMUSP00000030306","abundance":0.985,"rank":11104,"name":"Hook1","annotation":"Protein Hook homolog 1; Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity)."},{"id":"ENSMUSP00000032133","abundance":0.985,"rank":11105,"name":"Gp9","annotation":"Platelet glycoprotein IX; The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib (By similarity)."},{"id":"ENSMUSP00000114467","abundance":0.984,"rank":11106,"name":"Osgin1","annotation":"Oxidative stress-induced growth inhibitor 1; Regulates the differentiation and proliferation through the regulation of cell death."},{"id":"ENSMUSP00000057143","abundance":0.984,"rank":11107,"name":"Gimap7","annotation":"GTPase, IMAP family member 7."},{"id":"ENSMUSP00000110478","abundance":0.984,"rank":11108,"name":"Rnf26","annotation":"E3 ubiquitin-protein ligase RNF26; E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the [...] "},{"id":"ENSMUSP00000140405","abundance":0.984,"rank":11109,"name":"Gm49380","annotation":"Predicted gene, 49380."},{"id":"ENSMUSP00000151011","abundance":0.984,"rank":11110,"name":"Olfr231","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000136622","abundance":0.983,"rank":11111,"name":"Tac2","annotation":"Neurokinin-B; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity); Belongs to the tachykinin family."},{"id":"ENSMUSP00000030469","abundance":0.983,"rank":11112,"name":"Lurap1","annotation":"Leucine rich adaptor protein 1; Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly [...] "},{"id":"ENSMUSP00000158452","abundance":0.983,"rank":11113,"name":"Vmn1r233","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000052107","abundance":0.983,"rank":11114,"name":"Ttc7b","annotation":"Tetratricopeptide repeat protein 7B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions."},{"id":"ENSMUSP00000149847","abundance":0.983,"rank":11115,"name":"Olfr594","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000043718","abundance":0.983,"rank":11116,"name":"Pramel1","annotation":"Preferentially expressed antigen in melanoma-like protein 1; May play a role in acrosome development and also in sperm maturation and motility; Belongs to the PRAME family."},{"id":"ENSMUSP00000022124","abundance":0.983,"rank":11117,"name":"Cd180","annotation":"CD180 antigen; May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B- cells."},{"id":"ENSMUSP00000048695","abundance":0.982,"rank":11118,"name":"Znrd1as","annotation":"Putative uncharacterized protein ZNRD1-AS1; May be involved in male sterility."},{"id":"ENSMUSP00000149174","abundance":0.982,"rank":11119,"name":"Olfr572","annotation":"Olfactory receptor MOR10-2."},{"id":"ENSMUSP00000091769","abundance":0.982,"rank":11120,"name":"Tlnrd1","annotation":"Talin rod domain-containing protein 1; Actin-binding protein which may have an oncogenic function and regulates cell proliferation, migration and invasion in cancer cells."},{"id":"ENSMUSP00000034060","abundance":0.982,"rank":11121,"name":"Sh3rf1","annotation":"E3 ubiquitin-protein ligase SH3RF1; Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing its dynamin- dependent and clathrin-independent endocytosis (By similarity). Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the J [...] "},{"id":"ENSMUSP00000058002","abundance":0.981,"rank":11122,"name":"Spata33","annotation":"Spermatogenesis-associated protein 33."},{"id":"ENSMUSP00000066841","abundance":0.98,"rank":11123,"name":"Nlrp4a","annotation":"NACHT, LRR and PYD domains-containing protein 4A; May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors."},{"id":"ENSMUSP00000125300","abundance":0.98,"rank":11124,"name":"Nsmce4a","annotation":"Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids."},{"id":"ENSMUSP00000082197","abundance":0.98,"rank":11125,"name":"Ptpn21","annotation":"Tyrosine-protein phosphatase non-receptor type 21; May be involved in the regulation of growth and differentiation of liver cells; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily."},{"id":"ENSMUSP00000101036","abundance":0.98,"rank":11126,"name":"Cfap410","annotation":"Cilia- and flagella-associated protein 410; Plays a role in cilia formation and/or maintenance. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Involved in DNA damage repair (By similarity)."},{"id":"ENSMUSP00000132657","abundance":0.979,"rank":11127,"name":"Pate10","annotation":"Secreted TFP/Ly-6/uPAR protein PATE-N."},{"id":"ENSMUSP00000136453","abundance":0.979,"rank":11128,"name":"Tbc1d10a","annotation":"TBC1 domain family member 10A; Acts as GTPase-activating protein for RAB27A."},{"id":"ENSMUSP00000051069","abundance":0.979,"rank":11129,"name":"Zfp473","annotation":"Zinc finger protein 473 homolog; Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000085120","abundance":0.979,"rank":11130,"name":"Olfr262","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000092429","abundance":0.979,"rank":11131,"name":"Zbtb49","annotation":"Zinc finger and BTB domain-containing protein 49; Transcription factor. Inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription."},{"id":"ENSMUSP00000055521","abundance":0.979,"rank":11132,"name":"Mlkl","annotation":"Mixed lineage kinase domain-like protein; Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (By similarity)."},{"id":"ENSMUSP00000017908","abundance":0.979,"rank":11133,"name":"Zswim1","annotation":"Zinc finger SWIM domain-containing protein 1."},{"id":"ENSMUSP00000009411","abundance":0.979,"rank":11134,"name":"Zfp212","annotation":"Zinc finger protein 212."},{"id":"ENSMUSP00000124674","abundance":0.978,"rank":11135,"name":"Kif6","annotation":"Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family."},{"id":"ENSMUSP00000022721","abundance":0.978,"rank":11136,"name":"Cln5","annotation":"Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form; Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane; Belongs to the CLN5 family."},{"id":"ENSMUSP00000145211","abundance":0.977,"rank":11137,"name":"Gimap3","annotation":"GTPase IMAP family member 3; During thymocyte development, may support the positive selection of CD4 and CD8 T cells. May play a role in mitochondrial DNA segregation in hematopoietic tissues. Binds GTP."},{"id":"ENSMUSP00000097144","abundance":0.977,"rank":11138,"name":"Fam8a1","annotation":"Family with sequence similarity 8, member A1."},{"id":"ENSMUSP00000020554","abundance":0.977,"rank":11139,"name":"Madcam1","annotation":"Mucosal addressin cell adhesion molecule 1; Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin- like domain, may be specialized in supporting integrin alpha-4/beta-7- dependent adhesion strengthening, independent of L-selectin binding."},{"id":"ENSMUSP00000014118","abundance":0.976,"rank":11140,"name":"Mcemp1","annotation":"Mast cell-expressed membrane protein 1."},{"id":"ENSMUSP00000107091","abundance":0.976,"rank":11141,"name":"C1qtnf4","annotation":"Complement C1q tumor necrosis factor-related protein 4; May be involved in the regulation of the inflammatory network. The role as pro- or anti-inflammatory seems to be context dependent (By similarity). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post- injection (Probable)."},{"id":"ENSMUSP00000022820","abundance":0.975,"rank":11142,"name":"Dhrs2","annotation":"Dehydrogenase/reductase member 2."},{"id":"ENSMUSP00000029908","abundance":0.975,"rank":11143,"name":"Faxc","annotation":"Failed axon connections homolog; May play a role in axonal development; Belongs to the FAX family."},{"id":"ENSMUSP00000053869","abundance":0.975,"rank":11144,"name":"Elfn1","annotation":"Protein ELFN1; Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and acts as a regulator of presynaptic release probability to direct the formation of highly facilitating pyramidal-OLM synapses. Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes."},{"id":"ENSMUSP00000056043","abundance":0.975,"rank":11145,"name":"Alkbh2","annotation":"DNA oxidative demethylase ALKBH2; Dioxygenase that repairs alkylated DNA and RNA containing 1- methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine. Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron."},{"id":"ENSMUSP00000120287","abundance":0.975,"rank":11146,"name":"Txndc16","annotation":"Thioredoxin domain-containing protein 16."},{"id":"ENSMUSP00000029650","abundance":0.974,"rank":11147,"name":"Ints12","annotation":"Integrator complex subunit 12; Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'- box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex."},{"id":"ENSMUSP00000021870","abundance":0.974,"rank":11148,"name":"Slc35b3","annotation":"Adenosine 3'-phospho 5'-phosphosulfate transporter 2; Mediates the transport of adenosine 3'-phospho 5'- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon (By similarity). Belongs to the nucleotide-sugar transporter family. SLC35B subfamily."},{"id":"ENSMUSP00000044580","abundance":0.973,"rank":11149,"name":"Ttbk1","annotation":"Tau-tubulin kinase 1; Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU (By similarity); Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family."},{"id":"ENSMUSP00000016106","abundance":0.973,"rank":11150,"name":"1700016C15Rik","annotation":"Uncharacterized protein C1orf100 homolog."},{"id":"ENSMUSP00000025078","abundance":0.973,"rank":11151,"name":"Map3k8","annotation":"Mitogen-activated protein kinase kinase kinase 8; Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a [...] "},{"id":"ENSMUSP00000028972","abundance":0.973,"rank":11152,"name":"Pdrg1","annotation":"P53 and DNA damage-regulated protein 1; May play a role in chaperone-mediated protein folding. Belongs to the prefoldin subunit beta family."},{"id":"ENSMUSP00000105783","abundance":0.973,"rank":11153,"name":"Tatdn1","annotation":"Putative deoxyribonuclease TATDN1; Putative deoxyribonuclease; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family."},{"id":"ENSMUSP00000132646","abundance":0.973,"rank":11154,"name":"Shisa9","annotation":"Protein shisa-9; Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses; Belongs to the shisa family. SHISA9 subfamily."},{"id":"ENSMUSP00000059166","abundance":0.973,"rank":11155,"name":"Edrf1","annotation":"Erythroid differentiation-related factor 1; Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene (By similarity)."},{"id":"ENSMUSP00000108554","abundance":0.972,"rank":11156,"name":"Zbtb6","annotation":"Zinc finger and BTB domain-containing protein 6; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000126976","abundance":0.972,"rank":11157,"name":"Gm9008","annotation":"Predicted pseudogene 9008."},{"id":"ENSMUSP00000150390","abundance":0.972,"rank":11158,"name":"Olfr622","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000056156","abundance":0.972,"rank":11159,"name":"Ufsp1","annotation":"Ufm1-specific protease 1; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins; Belongs to the peptidase C78 family."},{"id":"ENSMUSP00000150086","abundance":0.971,"rank":11160,"name":"Olfr328","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000057489","abundance":0.971,"rank":11161,"name":"Nhlh1","annotation":"Helix-loop-helix protein 1; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system."},{"id":"ENSMUSP00000030080","abundance":0.971,"rank":11162,"name":"Snx30","annotation":"Sorting nexin-30; May be involved in several stages of intracellular trafficking."},{"id":"ENSMUSP00000051132","abundance":0.971,"rank":11163,"name":"Oxtr","annotation":"Oxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily."},{"id":"ENSMUSP00000025263","abundance":0.97,"rank":11164,"name":"Tnf","annotation":"Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces  [...] "},{"id":"ENSMUSP00000033828","abundance":0.97,"rank":11165,"name":"Gas6","annotation":"Growth arrest-specific protein 6; Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses."},{"id":"ENSMUSP00000108161","abundance":0.969,"rank":11166,"name":"Gm15155","annotation":"Predicted gene 15155."},{"id":"ENSMUSP00000055486","abundance":0.969,"rank":11167,"name":"Osr1","annotation":"Protein odd-skipped-related 1; Transcription factor that plays a role in the regulation of embryonic heart and urogenital development."},{"id":"ENSMUSP00000149756","abundance":0.969,"rank":11168,"name":"Gm4922","annotation":"Sperm motility kinase Z; May play a role in sperm motility, especially in the regulation of flagellar function."},{"id":"ENSMUSP00000036032","abundance":0.968,"rank":11169,"name":"Ky","annotation":"Kyphoscoliosis peptidase; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC."},{"id":"ENSMUSP00000110751","abundance":0.968,"rank":11170,"name":"Fam171a1","annotation":"Family with sequence similarity 171, member A1."},{"id":"ENSMUSP00000112121","abundance":0.968,"rank":11171,"name":"Trmt5","annotation":"tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding."},{"id":"ENSMUSP00000021606","abundance":0.968,"rank":11172,"name":"Atxn3","annotation":"Ataxin-3; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In [...] "},{"id":"ENSMUSP00000023619","abundance":0.968,"rank":11173,"name":"Stfa2","annotation":"Cystatin-A/B."},{"id":"ENSMUSP00000063140","abundance":0.968,"rank":11174,"name":"Fam25c","annotation":"Protein FAM25C; Belongs to the FAM25 family."},{"id":"ENSMUSP00000098436","abundance":0.968,"rank":11175,"name":"Selplg","annotation":"P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture."},{"id":"ENSMUSP00000069326","abundance":0.966,"rank":11176,"name":"Pld5","annotation":"Inactive phospholipase D5; Belongs to the phospholipase D family."},{"id":"ENSMUSP00000084399","abundance":0.966,"rank":11177,"name":"Klhl34","annotation":"Kelch-like 34."},{"id":"ENSMUSP00000156805","abundance":0.966,"rank":11178,"name":"Vmn2r60","annotation":"Vomeronasal 2, receptor 60."},{"id":"ENSMUSP00000015855","abundance":0.966,"rank":11179,"name":"Prune1","annotation":"Exopolyphosphatase PRUNE1; Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization."},{"id":"ENSMUSP00000132305","abundance":0.966,"rank":11180,"name":"Zfp558","annotation":"Zinc finger protein 558."},{"id":"ENSMUSP00000124930","abundance":0.965,"rank":11181,"name":"Zfp957","annotation":"Zinc finger protein 957."},{"id":"ENSMUSP00000062312","abundance":0.965,"rank":11182,"name":"Upk3b","annotation":"Uroplakin-3b; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity)."},{"id":"ENSMUSP00000052716","abundance":0.964,"rank":11183,"name":"Fbxl13","annotation":"Dynein regulatory complex subunit 6; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the DRC6 family."},{"id":"ENSMUSP00000023213","abundance":0.964,"rank":11184,"name":"Hgh1","annotation":"Protein HGH1 homolog; Belongs to the HGH1 family."},{"id":"ENSMUSP00000104453","abundance":0.964,"rank":11185,"name":"Gm12253","annotation":"Predicted gene 12253."},{"id":"ENSMUSP00000040364","abundance":0.964,"rank":11186,"name":"Neurod1","annotation":"Neurogenic differentiation factor 1; Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or  [...] "},{"id":"ENSMUSP00000003946","abundance":0.963,"rank":11187,"name":"Nob1","annotation":"RNA-binding protein NOB1; May play a role in mRNA degradation (By similarity). Endonuclease required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits (By similarity)."},{"id":"ENSMUSP00000006105","abundance":0.963,"rank":11188,"name":"Shpk","annotation":"Sedoheptulokinase; Acts as a modulator of macrophage activation through control of glucose metabolism."},{"id":"ENSMUSP00000001415","abundance":0.963,"rank":11189,"name":"Apbb3","annotation":"Amyloid-beta A4 precursor protein-binding family B member 3; May modulate the internalization of amyloid-beta precursor protein."},{"id":"ENSMUSP00000022224","abundance":0.963,"rank":11190,"name":"Trappc13","annotation":"Trafficking protein particle complex subunit 13; Belongs to the TRAPPC13 family."},{"id":"ENSMUSP00000118312","abundance":0.963,"rank":11191,"name":"Slf1","annotation":"SMC5-SMC6 complex localization factor protein 1; Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions."},{"id":"ENSMUSP00000131204","abundance":0.963,"rank":11192,"name":"1700093K21Rik","annotation":"Uncharacterized protein C2orf74 homolog."},{"id":"ENSMUSP00000074661","abundance":0.963,"rank":11193,"name":"Kif21b","annotation":"Kinesin-like protein KIF21B; Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface."},{"id":"ENSMUSP00000072688","abundance":0.962,"rank":11194,"name":"Zswim7","annotation":"Zinc finger SWIM domain-containing protein 7; Involved in early stages of the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents."},{"id":"ENSMUSP00000002284","abundance":0.962,"rank":11195,"name":"Plaur","annotation":"Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA."},{"id":"ENSMUSP00000156546","abundance":0.962,"rank":11196,"name":"Vmn1r230","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000053129","abundance":0.962,"rank":11197,"name":"Baiap2l1","annotation":"Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection (By similarity)."},{"id":"ENSMUSP00000061769","abundance":0.962,"rank":11198,"name":"Rps6kc1","annotation":"Ribosomal protein S6 kinase delta-1; May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell. Plays a role in the recruitment of PRDX3 to early endosomes."},{"id":"ENSMUSP00000047900","abundance":0.961,"rank":11199,"name":"Dusp5","annotation":"Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000015394","abundance":0.96,"rank":11200,"name":"Mmp13","annotation":"Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] "},{"id":"ENSMUSP00000005016","abundance":0.96,"rank":11201,"name":"Rrnad1","annotation":"Protein RRNAD1; Belongs to the RRNAD1 family."},{"id":"ENSMUSP00000091026","abundance":0.96,"rank":11202,"name":"2610318N02Rik","annotation":"RIKEN cDNA 2610318N02 gene."},{"id":"ENSMUSP00000112963","abundance":0.96,"rank":11203,"name":"Taok2","annotation":"Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] "},{"id":"ENSMUSP00000046522","abundance":0.959,"rank":11204,"name":"Prl3a1","annotation":"Prolactin family 3, subfamily a, member 1."},{"id":"ENSMUSP00000017799","abundance":0.959,"rank":11205,"name":"Cd40","annotation":"Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion."},{"id":"ENSMUSP00000045973","abundance":0.959,"rank":11206,"name":"Six5","annotation":"Homeobox protein SIX5; Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3."},{"id":"ENSMUSP00000052755","abundance":0.959,"rank":11207,"name":"Dcaf5","annotation":"DDB1- and CUL4-associated factor 5; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex."},{"id":"ENSMUSP00000034602","abundance":0.959,"rank":11208,"name":"Cd3d","annotation":"T-cell surface glycoprotein CD3 delta chain; Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR- mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of  [...] "},{"id":"ENSMUSP00000103540","abundance":0.958,"rank":11209,"name":"Kcnc3","annotation":"Potassium voltage-gated channel subfamily C member 3; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics. It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar  [...] "},{"id":"ENSMUSP00000022613","abundance":0.958,"rank":11210,"name":"Esco2","annotation":"N-acetyltransferase ESCO2; Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3."},{"id":"ENSMUSP00000129823","abundance":0.958,"rank":11211,"name":"Gm50241","annotation":"Decreased expression in renal and prostate cancer protein; Potential tumor suppressor; Belongs to the DERPC family."},{"id":"ENSMUSP00000021135","abundance":0.957,"rank":11212,"name":"Ncbp3","annotation":"Nuclear cap-binding protein subunit 3; Associates with NCBP1/CBP80 to form an alternative cap- binding complex (CBC) which plays a key role in mRNA export. NCBP3 serves as adapter protein linking the capped RNAs (m7GpppG-capped RNA) to NCBP1/CBP80. Unlike the conventional CBC with NCBP2 which binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus, the alternative CBC with NCBP3 does not bind snRNA and associates only with mRNA thereby playing a role in only mRNA export. The alternative CBC is particularly important in cellular stress  [...] "},{"id":"ENSMUSP00000114004","abundance":0.957,"rank":11213,"name":"Klra4","annotation":"Killer cell lectin-like receptor 4; Receptor on natural killer (NK) cells for class I MHC."},{"id":"ENSMUSP00000019482","abundance":0.957,"rank":11214,"name":"Zfp687","annotation":"Zinc finger protein 687; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000106137","abundance":0.957,"rank":11215,"name":"Gli3","annotation":"Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] "},{"id":"ENSMUSP00000034984","abundance":0.956,"rank":11216,"name":"Rasa2","annotation":"Ras GTPase-activating protein 2; Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) and phospholipids."},{"id":"ENSMUSP00000023913","abundance":0.956,"rank":11217,"name":"Wrb","annotation":"Tail-anchored protein insertion receptor WRB; Receptor for ASNA1/TRC40-mediated insertion of tail-anchored (TA) proteins into the ER membrane."},{"id":"ENSMUSP00000024873","abundance":0.956,"rank":11218,"name":"Yipf4","annotation":"Protein YIPF4; Involved in the maintenance of the Golgi structure. Belongs to the YIP1 family."},{"id":"ENSMUSP00000073399","abundance":0.956,"rank":11219,"name":"1700001J03Rik","annotation":"RIKEN cDNA 1700001J03 gene."},{"id":"ENSMUSP00000062386","abundance":0.955,"rank":11220,"name":"Pheta1","annotation":"Sesquipedalian-1; Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane."},{"id":"ENSMUSP00000033189","abundance":0.955,"rank":11221,"name":"Cckbr","annotation":"Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000113634","abundance":0.954,"rank":11222,"name":"Vps9d1","annotation":"VPS9 domain-containing protein 1."},{"id":"ENSMUSP00000038722","abundance":0.953,"rank":11223,"name":"Pomt1","annotation":"Protein O-mannosyl-transferase 1; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins."},{"id":"ENSMUSP00000157960","abundance":0.953,"rank":11224,"name":"Ankrd1","annotation":"Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes."},{"id":"ENSMUSP00000128922","abundance":0.953,"rank":11225,"name":"Ttpal","annotation":"Alpha-tocopherol transfer protein-like; May act as a protein that binds a hydrophobic ligand."},{"id":"ENSMUSP00000108460","abundance":0.953,"rank":11226,"name":"9630041A04Rik","annotation":"RIKEN cDNA 9630041A04 gene."},{"id":"ENSMUSP00000052591","abundance":0.953,"rank":11227,"name":"Tbx20","annotation":"T-box transcription factor TBX20; Acts as a transcriptional activator and repressor required for cardiac development and may have key roles in the maintenance of functional and structural phenotypes in adult heart."},{"id":"ENSMUSP00000102072","abundance":0.953,"rank":11228,"name":"Ccdc163","annotation":"Coiled-coil domain-containing 163."},{"id":"ENSMUSP00000125952","abundance":0.953,"rank":11229,"name":"Minar2","annotation":"Major intrinsically disordered NOTCH2-binding receptor 1-like homolog; Belongs to the MINAR family."},{"id":"ENSMUSP00000000305","abundance":0.953,"rank":11230,"name":"Tpd52l1","annotation":"Tumor protein D53."},{"id":"ENSMUSP00000021666","abundance":0.952,"rank":11231,"name":"Abcd4","annotation":"ATP-binding cassette sub-family D member 4; May be involved in intracellular processing of vitamin B12 (cobalamin). Could play a role in the lysosomal release of vitamin B12 into the cytoplasm (By similarity)."},{"id":"ENSMUSP00000037497","abundance":0.952,"rank":11232,"name":"Akp3","annotation":"Intestinal-type alkaline phosphatase."},{"id":"ENSMUSP00000002044","abundance":0.952,"rank":11233,"name":"Map3k3","annotation":"Mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators."},{"id":"ENSMUSP00000055318","abundance":0.951,"rank":11234,"name":"Yod1","annotation":"Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. A [...] "},{"id":"ENSMUSP00000102194","abundance":0.951,"rank":11235,"name":"Gpr142","annotation":"Probable G-protein coupled receptor 142; Orphan receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000075924","abundance":0.951,"rank":11236,"name":"Arap2","annotation":"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity)."},{"id":"ENSMUSP00000109010","abundance":0.951,"rank":11237,"name":"Flrt1","annotation":"Leucine-rich repeat transmembrane protein FLRT1; Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3."},{"id":"ENSMUSP00000021231","abundance":0.951,"rank":11238,"name":"Abcc3","annotation":"Canalicular multispecific organic anion transporter 2; May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes."},{"id":"ENSMUSP00000152525","abundance":0.951,"rank":11239,"name":"Slc6a18","annotation":"Sodium-dependent neutral amino acid transporter B(0)AT3; Functions as a sodium and chloride-dependent neutral amino acid transporter in kidneys. Required CLTRN for cell surface expression and for its amino acid transporter activity."},{"id":"ENSMUSP00000023501","abundance":0.95,"rank":11240,"name":"Maats1","annotation":"Cilia- and flagella-associated protein 91; May regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity). May play a role in spermatogenesis."},{"id":"ENSMUSP00000093992","abundance":0.95,"rank":11241,"name":"Cpped1","annotation":"Serine/threonine-protein phosphatase CPPED1; Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes (By similarity); Belongs to the metallophosphoesterase superfamily. CPPED1 family."},{"id":"ENSMUSP00000132095","abundance":0.95,"rank":11242,"name":"Banp","annotation":"Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest and inhibits tumor growth."},{"id":"ENSMUSP00000139555","abundance":0.95,"rank":11243,"name":"Cxcr1","annotation":"C-X-C chemokine receptor type 1; Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system (By similarity)."},{"id":"ENSMUSP00000029891","abundance":0.95,"rank":11244,"name":"Tmem68","annotation":"Transmembrane protein 68."},{"id":"ENSMUSP00000020223","abundance":0.95,"rank":11245,"name":"Tcp11l2","annotation":"T-complex protein 11-like protein 2; Belongs to the TCP11 family."},{"id":"ENSMUSP00000028937","abundance":0.95,"rank":11246,"name":"Cstdc2","annotation":"Cystatin domain-containing 2."},{"id":"ENSMUSP00000047275","abundance":0.95,"rank":11247,"name":"Abitram","annotation":"Protein Abitram; Actin-binding protein that regulates actin polymerization, filopodia dynamics and increases the branching of proximal dendrites of developing neurons; Belongs to the ABITRAM family."},{"id":"ENSMUSP00000020523","abundance":0.949,"rank":11248,"name":"Pex13","annotation":"Peroxisomal membrane protein PEX13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins (By similarity)."},{"id":"ENSMUSP00000020413","abundance":0.949,"rank":11249,"name":"Zpbp","annotation":"Zona pellucida-binding protein 1; Plays a role in acrosome compaction and sperm morphogenesis. Is implicated in sperm-oocyte interaction during fertilization. Belongs to the zona pellucida-binding protein Sp38 family."},{"id":"ENSMUSP00000139698","abundance":0.949,"rank":11250,"name":"Kif14","annotation":"Kinesin-like protein KIF14; Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity. Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis (By similarity). During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively (By similarity). Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent pr [...] "},{"id":"ENSMUSP00000055293","abundance":0.949,"rank":11251,"name":"Arhgef39","annotation":"Rho guanine nucleotide exchange factor 39; Promotes cell proliferation."},{"id":"ENSMUSP00000110316","abundance":0.948,"rank":11252,"name":"Slc5a6","annotation":"Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family."},{"id":"ENSMUSP00000113162","abundance":0.948,"rank":11253,"name":"Ankle1","annotation":"Ankyrin repeat and LEM domain-containing protein 1; Endonuclease that probably plays a role in the DNA damage response and DNA repair."},{"id":"ENSMUSP00000055605","abundance":0.948,"rank":11254,"name":"Diras1","annotation":"GTP-binding protein Di-Ras1; Displays low GTPase activity and exists predominantly in the GTP-bound form; Belongs to the small GTPase superfamily. Di-Ras family."},{"id":"ENSMUSP00000058761","abundance":0.947,"rank":11255,"name":"Olfml2a","annotation":"Olfactomedin-like protein 2A."},{"id":"ENSMUSP00000026537","abundance":0.947,"rank":11256,"name":"Paox","annotation":"Peroxisomal N(1)-acetyl-spermine/spermidine oxidase; Flavoenzyme which catalyzes the oxidation of N(1)- acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)- acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs."},{"id":"ENSMUSP00000042701","abundance":0.947,"rank":11257,"name":"Spon2","annotation":"Spondin-2; Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Binds bacterial lipopolysaccharide. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens."},{"id":"ENSMUSP00000137516","abundance":0.947,"rank":11258,"name":"Mfsd4b4","annotation":"Major facilitator superfamily domain-containing 4B4."},{"id":"ENSMUSP00000068187","abundance":0.947,"rank":11259,"name":"Sertad3","annotation":"SERTA domain-containing protein 3; Strong transcriptional coactivator."},{"id":"ENSMUSP00000028836","abundance":0.946,"rank":11260,"name":"Bmp2","annotation":"Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Belongs to the TGF-beta family."},{"id":"ENSMUSP00000104751","abundance":0.945,"rank":11261,"name":"4933414I15Rik","annotation":"RIKEN cDNA 4933414I15 gene."},{"id":"ENSMUSP00000091595","abundance":0.945,"rank":11262,"name":"Tnrc6a","annotation":"Trinucleotide repeat-containing gene 6A protein; Plays a role in RNA-mediated gene silencing by both micro- RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA- dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes (By similarity)."},{"id":"ENSMUSP00000033501","abundance":0.945,"rank":11263,"name":"Hdac6","annotation":"Histone deacetylase 6; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. In addition to histones, deacetylates other proteins: plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. In addition to its protein deacetylase activity, pla [...] "},{"id":"ENSMUSP00000017945","abundance":0.945,"rank":11264,"name":"Mlx","annotation":"Max-like protein X; Transcription regulator. Forms a sequence-specific DNA- binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation."},{"id":"ENSMUSP00000032217","abundance":0.944,"rank":11265,"name":"Lag3","annotation":"Secreted lymphocyte activation gene 3 protein; Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, act [...] "},{"id":"ENSMUSP00000023157","abundance":0.944,"rank":11266,"name":"Anks3","annotation":"Ankyrin repeat and SAM domain-containing protein 3; May be involved in vasopressin signaling in the kidney."},{"id":"ENSMUSP00000021997","abundance":0.944,"rank":11267,"name":"Rsl1","annotation":"Regulator of sex limited protein 1."},{"id":"ENSMUSP00000145077","abundance":0.944,"rank":11268,"name":"Rasgef1a","annotation":"RasGEF domain family, member 1A."},{"id":"ENSMUSP00000050184","abundance":0.944,"rank":11269,"name":"Olfr745","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000026795","abundance":0.943,"rank":11270,"name":"Alox5","annotation":"Arachidonate 5-lipoxygenase; Catalyzes the first step in leukotriene biosynthesis, and thereby plays a role in inflammatory processes. Belongs to the lipoxygenase family."},{"id":"ENSMUSP00000121811","abundance":0.943,"rank":11271,"name":"Maskbp3","annotation":"Multiple ankyrin repeats single KH domain-binding protein 3."},{"id":"ENSMUSP00000036695","abundance":0.943,"rank":11272,"name":"Eva1c","annotation":"Protein eva-1 homolog C; Binds heparin; Belongs to the EVA1 family."},{"id":"ENSMUSP00000039071","abundance":0.943,"rank":11273,"name":"Mxd4","annotation":"Max dimerization protein 4; Transcriptional repressor. Binds with MAX to form a sequence- specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation."},{"id":"ENSMUSP00000045454","abundance":0.942,"rank":11274,"name":"Rad54l2","annotation":"Helicase ARIP4; DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro. Acts as an AR-coregulator in Sertoli cells."},{"id":"ENSMUSP00000093089","abundance":0.942,"rank":11275,"name":"Xkr5","annotation":"XK-related protein 5."},{"id":"ENSMUSP00000022446","abundance":0.942,"rank":11276,"name":"Eaf1","annotation":"ELL-associated factor 1; Acts as a transcriptional transactivator of ELL and ELL2 elongation activities."},{"id":"ENSMUSP00000121032","abundance":0.942,"rank":11277,"name":"Sik3","annotation":"Serine/threonine-protein kinase SIK3; Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor (By similarity). Required for chondrocyte hypertrophy during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (By similarity). Prevents HDAC4 translocation to the nucleus. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily."},{"id":"ENSMUSP00000064961","abundance":0.942,"rank":11278,"name":"Susd6","annotation":"Sushi domain-containing protein 6; May play a role in growth-suppressive activity and cell death. May be involved in the production of chemokine molecules in umbilical vein endothelial cells (HUVECs) cultured in THP1 monocyte LPS-induced medium (By similarity). Plays a role in preventing tumor onset."},{"id":"ENSMUSP00000030868","abundance":0.941,"rank":11279,"name":"Sema3d","annotation":"Semaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity)."},{"id":"ENSMUSP00000074255","abundance":0.941,"rank":11280,"name":"Ubxn11","annotation":"UBX domain-containing protein 11; May be involved in the reorganization of actin cytoskeleton mediated by RND1, RND2 AND RND3. Promotes RHOA activation mediated by GNA12 and GNA13 (By similarity)."},{"id":"ENSMUSP00000036491","abundance":0.941,"rank":11281,"name":"Mtg1","annotation":"Mitochondrial ribosome-associated GTPase 1; Plays a role in the regulation of the mitochondrial ribosome assembly and of translational activity (By similarity). Displays mitochondrial GTPase activity (By similarity)."},{"id":"ENSMUSP00000037860","abundance":0.941,"rank":11282,"name":"Rnf39","annotation":"Ring finger protein 39."},{"id":"ENSMUSP00000027956","abundance":0.941,"rank":11283,"name":"Suv39h2","annotation":"Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] "},{"id":"ENSMUSP00000127795","abundance":0.941,"rank":11284,"name":"Gm3424","annotation":"Predicted gene 3424."},{"id":"ENSMUSP00000138067","abundance":0.941,"rank":11285,"name":"Gm8246","annotation":"Predicted gene 8246."},{"id":"ENSMUSP00000111322","abundance":0.941,"rank":11286,"name":"Pcdha11-2","annotation":"Protocadherin alpha-10; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain."},{"id":"ENSMUSP00000106401","abundance":0.94,"rank":11287,"name":"Mga","annotation":"MAX gene-associated protein; Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'- AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corep [...] "},{"id":"ENSMUSP00000113436","abundance":0.94,"rank":11288,"name":"Kcnd3","annotation":"Potassium voltage-gated channel subfamily D member 3; Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits."},{"id":"ENSMUSP00000052172","abundance":0.94,"rank":11289,"name":"Slc38a9","annotation":"Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] "},{"id":"ENSMUSP00000038043","abundance":0.94,"rank":11290,"name":"2300002M23Rik","annotation":"Uncharacterized protein C6orf15 homolog."},{"id":"ENSMUSP00000073789","abundance":0.94,"rank":11291,"name":"Ak8","annotation":"Adenylate kinase 8; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity."},{"id":"ENSMUSP00000124641","abundance":0.939,"rank":11292,"name":"Gm28374","annotation":"Predicted gene 28374."},{"id":"ENSMUSP00000153959","abundance":0.938,"rank":11293,"name":"Vmn1r35","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000079238","abundance":0.938,"rank":11294,"name":"Atp8a2","annotation":"Phospholipid-transporting ATPase IB; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). [...] "},{"id":"ENSMUSP00000062540","abundance":0.938,"rank":11295,"name":"Ccdc137","annotation":"Coiled-coil domain-containing protein 137."},{"id":"ENSMUSP00000151008","abundance":0.938,"rank":11296,"name":"Olfr906","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000104047","abundance":0.938,"rank":11297,"name":"Prr19","annotation":"Proline-rich 19."},{"id":"ENSMUSP00000028761","abundance":0.938,"rank":11298,"name":"Ubox5","annotation":"RING finger protein 37; May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates."},{"id":"ENSMUSP00000012152","abundance":0.938,"rank":11299,"name":"Dgcr2","annotation":"Integral membrane protein DGCR2/IDD; Probably plays a role in neural crest cell migration. May play a role in delivery of extracellular signals."},{"id":"ENSMUSP00000025101","abundance":0.938,"rank":11300,"name":"Dync2li1","annotation":"Cytoplasmic dynein 2 light intermediate chain 1; Required for correct intraflagellar transport (IFT), the bi- directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Involved in the regulation of ciliary length (By similarity). Belongs to the dynein light intermediate chain family."},{"id":"ENSMUSP00000029742","abundance":0.937,"rank":11301,"name":"Nudt17","annotation":"Nucleoside diphosphate-linked moiety X motif 17; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives."},{"id":"ENSMUSP00000123234","abundance":0.937,"rank":11302,"name":"Grip1","annotation":"Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (By similarity). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity)."},{"id":"ENSMUSP00000158187","abundance":0.937,"rank":11303,"name":"Zfand5","annotation":"AN1-type zinc finger protein 5; Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent [...] "},{"id":"ENSMUSP00000070896","abundance":0.937,"rank":11304,"name":"Rai1","annotation":"Retinoic acid-induced protein 1; Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation."},{"id":"ENSMUSP00000150649","abundance":0.936,"rank":11305,"name":"Olfr1423","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000157102","abundance":0.936,"rank":11306,"name":"Rnf138","annotation":"E3 ubiquitin-protein ligase RNF138; E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex [...] "},{"id":"ENSMUSP00000054774","abundance":0.936,"rank":11307,"name":"Pcdh20","annotation":"Protocadherin-20; Potential calcium-dependent cell-adhesion protein."},{"id":"ENSMUSP00000138773","abundance":0.935,"rank":11308,"name":"Prss56","annotation":"Serine protease 56; Serine protease required during eye development."},{"id":"ENSMUSP00000153015","abundance":0.934,"rank":11309,"name":"Fbxo16","annotation":"F-box only protein 16; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation."},{"id":"ENSMUSP00000056154","abundance":0.933,"rank":11310,"name":"Zfp830","annotation":"Zinc finger protein 830; May play a role in pre-mRNA splicing as component of the spliceosome (By similarity). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During ear [...] "},{"id":"ENSMUSP00000091469","abundance":0.933,"rank":11311,"name":"Cdc6","annotation":"Cell division control protein 6 homolog; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated."},{"id":"ENSMUSP00000030528","abundance":0.933,"rank":11312,"name":"Pla2g2d","annotation":"Group IID secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined."},{"id":"ENSMUSP00000025075","abundance":0.932,"rank":11313,"name":"Bambi","annotation":"BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling."},{"id":"ENSMUSP00000123141","abundance":0.932,"rank":11314,"name":"Rasal3","annotation":"RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway."},{"id":"ENSMUSP00000038075","abundance":0.932,"rank":11315,"name":"Ccdc92","annotation":"Coiled-coil domain-containing protein 92."},{"id":"ENSMUSP00000089358","abundance":0.932,"rank":11316,"name":"Nme8","annotation":"Thioredoxin domain-containing protein 3; Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds (By similarity)."},{"id":"ENSMUSP00000061679","abundance":0.931,"rank":11317,"name":"Map10","annotation":"Microtubule-associated protein 10; Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis."},{"id":"ENSMUSP00000136062","abundance":0.931,"rank":11318,"name":"Dnajc4","annotation":"DnaJ homolog subfamily C member 4."},{"id":"ENSMUSP00000022665","abundance":0.931,"rank":11319,"name":"Rhobtb2","annotation":"Rho-related BTB domain-containing protein 2; Belongs to the small GTPase superfamily. Rho family."},{"id":"ENSMUSP00000155514","abundance":0.93,"rank":11320,"name":"Cacnb3","annotation":"Voltage-dependent L-type calcium channel subunit beta-3; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity)."},{"id":"ENSMUSP00000076085","abundance":0.93,"rank":11321,"name":"Pcdhgc3","annotation":"Protocadherin gamma subfamily C, 3."},{"id":"ENSMUSP00000029547","abundance":0.93,"rank":11322,"name":"Creb3l4","annotation":"Processed cyclic AMP-responsive element-binding protein 3-like protein 4; Transcriptional activator that may play a role in the unfolded protein response of the testis. Proposed to be involved in spermiogenesis. May be involved in regulating the maturation of sperm head nuclei. Alternatively proposed to be a paternally delivered transcription factor that may function in early zygotic gene activation. Increases the binding of CREM isoform Tau with CRE. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange."},{"id":"ENSMUSP00000018094","abundance":0.93,"rank":11323,"name":"Hnf4a","annotation":"Hepatocyte nuclear factor 4-alpha; Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitatating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38. Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells ; Belongs to the nuclear hormone receptor family. NR2 subfamily."},{"id":"ENSMUSP00000107598","abundance":0.929,"rank":11324,"name":"Vsig10","annotation":"V-set and immunoglobulin domain-containing protein 10."},{"id":"ENSMUSP00000059079","abundance":0.929,"rank":11325,"name":"Chd7","annotation":"Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity); Belongs to the SNF2/RAD54 helicase family."},{"id":"ENSMUSP00000105976","abundance":0.929,"rank":11326,"name":"Smoc1","annotation":"SPARC-related modular calcium-binding protein 1; Probable regulator of osteoblast differentiation. Plays essential roles in both eye and limb development."},{"id":"ENSMUSP00000026284","abundance":0.929,"rank":11327,"name":"Zfhx4","annotation":"Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation. May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000131169","abundance":0.929,"rank":11328,"name":"Apopt1","annotation":"Cytochrome c oxidase assembly factor 8; Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain. Belongs to the COA8 family."},{"id":"ENSMUSP00000106722","abundance":0.929,"rank":11329,"name":"Cldn15","annotation":"Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] "},{"id":"ENSMUSP00000075266","abundance":0.928,"rank":11330,"name":"Fbxo40","annotation":"F-box only protein 40; Probable substrate-recognition component of the SCF (SKP1- CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis."},{"id":"ENSMUSP00000070583","abundance":0.928,"rank":11331,"name":"Lpin1","annotation":"Phosphatidate phosphatase LPIN1; Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in m [...] "},{"id":"ENSMUSP00000028363","abundance":0.928,"rank":11332,"name":"Il1f8","annotation":"Interleukin-36 beta; Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL- 36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial [...] "},{"id":"ENSMUSP00000027243","abundance":0.927,"rank":11333,"name":"Il1r2","annotation":"Interleukin-1 receptor type 2, membrane form; Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity)."},{"id":"ENSMUSP00000091330","abundance":0.927,"rank":11334,"name":"Cd109","annotation":"CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes."},{"id":"ENSMUSP00000155515","abundance":0.927,"rank":11335,"name":"Ppp1r16a","annotation":"Protein phosphatase 1 regulatory subunit 16A; Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates."},{"id":"ENSMUSP00000026994","abundance":0.927,"rank":11336,"name":"Unc5a","annotation":"Netrin receptor UNC5A; Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand; Belongs to the unc-5 family."},{"id":"ENSMUSP00000024005","abundance":0.926,"rank":11337,"name":"Scg5","annotation":"Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro; Belongs to the 7B2 family."},{"id":"ENSMUSP00000029116","abundance":0.926,"rank":11338,"name":"Pcmtd2","annotation":"Protein-L-isoaspartate O-methyltransferase domain-containing protein 2."},{"id":"ENSMUSP00000050181","abundance":0.925,"rank":11339,"name":"Prmt9","annotation":"Protein arginine N-methyltransferase 9; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA."},{"id":"ENSMUSP00000081561","abundance":0.925,"rank":11340,"name":"Tacc2","annotation":"Transforming acidic coiled-coil-containing protein 2; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules (By similarity)."},{"id":"ENSMUSP00000113516","abundance":0.925,"rank":11341,"name":"Gjb1","annotation":"Gap junction beta-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Beta-type (group I) subfamily."},{"id":"ENSMUSP00000048817","abundance":0.925,"rank":11342,"name":"Hspa13","annotation":"Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Belongs to the heat shock protein 70 family."},{"id":"ENSMUSP00000049732","abundance":0.924,"rank":11343,"name":"Gltpd2","annotation":"Glycolipid transfer protein domain-containing protein 2; Belongs to the GLTP family."},{"id":"ENSMUSP00000136657","abundance":0.924,"rank":11344,"name":"Gm3383","annotation":"Predicted gene 3194."},{"id":"ENSMUSP00000137641","abundance":0.924,"rank":11345,"name":"Gm3194","annotation":"Predicted gene 3194."},{"id":"ENSMUSP00000101129","abundance":0.923,"rank":11346,"name":"Prdm1","annotation":"PR domain zinc finger protein 1; Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut,  [...] "},{"id":"ENSMUSP00000101614","abundance":0.923,"rank":11347,"name":"Nkain1","annotation":"Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1."},{"id":"ENSMUSP00000035271","abundance":0.923,"rank":11348,"name":"Prss35","annotation":"Inactive serine protease 35; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000025444","abundance":0.923,"rank":11349,"name":"Cxxc1","annotation":"CXXC-type zinc finger protein 1; Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG."},{"id":"ENSMUSP00000134531","abundance":0.923,"rank":11350,"name":"Obox3","annotation":"Oocyte-specific homeobox 3."},{"id":"ENSMUSP00000111001","abundance":0.923,"rank":11351,"name":"Crisp4","annotation":"Cysteine-rich secretory protein 4; Belongs to the CRISP family."},{"id":"ENSMUSP00000026699","abundance":0.922,"rank":11352,"name":"Mkln1","annotation":"Muskelin; Component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Required for internalization of the GABA receptor GABRA1 from the cell membrane via endosomes and subsequent GABRA1 degradation. Acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component THBS1."},{"id":"ENSMUSP00000079362","abundance":0.922,"rank":11353,"name":"Sbsn","annotation":"Suprabasin."},{"id":"ENSMUSP00000027649","abundance":0.922,"rank":11354,"name":"Nr5a2","annotation":"Nuclear receptor subfamily 5 group A member 2; Nuclear receptor that acts as a key metabolic sensor by regulating the expression of genes involved in bile acid synthesis, cholesterol homeostasis and triglyceride synthesis. Together with the oxysterol receptors NR1H3/LXR-alpha and NR1H2/LXR-beta, acts as an essential transcriptional regulator of lipid metabolism. Plays an anti- inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Key regulator of choles [...] "},{"id":"ENSMUSP00000140073","abundance":0.922,"rank":11355,"name":"Dvl2","annotation":"Segment polarity protein dishevelled homolog DVL-2; Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling."},{"id":"ENSMUSP00000040208","abundance":0.921,"rank":11356,"name":"Creb3l2","annotation":"Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...] "},{"id":"ENSMUSP00000132224","abundance":0.921,"rank":11357,"name":"Wwp2","annotation":"NEDD4-like E3 ubiquitin-protein ligase WWP2; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; regulates POU5F1 protein level during differentiation of embryonal carcinoma cells (ECCs) but not in undifferentiated ECCs and embryonic stem cells (ESCs). Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits acti [...] "},{"id":"ENSMUSP00000087054","abundance":0.921,"rank":11358,"name":"Csta3","annotation":"Cystatin A family member 3."},{"id":"ENSMUSP00000063957","abundance":0.92,"rank":11359,"name":"Mbd3l1","annotation":"Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor."},{"id":"ENSMUSP00000153776","abundance":0.92,"rank":11360,"name":"Vmn1r210","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000150921","abundance":0.919,"rank":11361,"name":"Olfr610","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000048680","abundance":0.919,"rank":11362,"name":"1700028P14Rik","annotation":"Protein C9orf135 homolog."},{"id":"ENSMUSP00000063609","abundance":0.919,"rank":11363,"name":"Mocos","annotation":"Molybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form."},{"id":"ENSMUSP00000071811","abundance":0.919,"rank":11364,"name":"Fbxw26","annotation":"F-box and WD-40 domain protein 26."},{"id":"ENSMUSP00000150171","abundance":0.919,"rank":11365,"name":"Olfr616","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000068101","abundance":0.919,"rank":11366,"name":"Gm4792","annotation":"Predicted gene, EG215472."},{"id":"ENSMUSP00000029450","abundance":0.918,"rank":11367,"name":"Tshb","annotation":"Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism."},{"id":"ENSMUSP00000099890","abundance":0.918,"rank":11368,"name":"Ifit2","annotation":"Interferon-induced protein with tetratricopeptide repeats 2; IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylati [...] "},{"id":"ENSMUSP00000092384","abundance":0.918,"rank":11369,"name":"Gipr","annotation":"Gastric inhibitory polypeptide receptor; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity)."},{"id":"ENSMUSP00000092624","abundance":0.917,"rank":11370,"name":"Tgfbrap1","annotation":"Transforming growth factor-beta receptor-associated protein 1; Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity); Belongs to the TRAP1 family."},{"id":"ENSMUSP00000138836","abundance":0.917,"rank":11371,"name":"Il6st","annotation":"Interleukin-6 receptor subunit beta; Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6 (By similarity). Essential for  [...] "},{"id":"ENSMUSP00000101164","abundance":0.917,"rank":11372,"name":"Ahi1","annotation":"Jouberin; Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development."},{"id":"ENSMUSP00000110220","abundance":0.917,"rank":11373,"name":"Sidt2","annotation":"SID1 transmembrane family member 2; Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA and DNA is directly imported into lysosomes in an ATP- dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double- stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than [...] "},{"id":"ENSMUSP00000052788","abundance":0.916,"rank":11374,"name":"Frat2","annotation":"GSK-3-binding protein FRAT2; Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3; Belongs to the GSK-3-binding protein family."},{"id":"ENSMUSP00000142202","abundance":0.916,"rank":11375,"name":"Gm42417","annotation":"Predicted gene, 42417."},{"id":"ENSMUSP00000121288","abundance":0.915,"rank":11376,"name":"Zfp758","annotation":"Zinc finger protein 758."},{"id":"ENSMUSP00000050730","abundance":0.915,"rank":11377,"name":"Svop","annotation":"Synaptic vesicle 2-related protein."},{"id":"ENSMUSP00000035154","abundance":0.915,"rank":11378,"name":"1110059G10Rik","annotation":"Uncharacterized protein KIAA1143 homolog."},{"id":"ENSMUSP00000127280","abundance":0.914,"rank":11379,"name":"Slc7a4","annotation":"Cationic amino acid transporter 4; Involved in the transport of the cationic amino acids (arginine, lysine and ornithine); Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family."},{"id":"ENSMUSP00000109687","abundance":0.914,"rank":11380,"name":"Tcf7l1","annotation":"Transcription factor 7-like 1; Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis."},{"id":"ENSMUSP00000124565","abundance":0.914,"rank":11381,"name":"Alkbh1","annotation":"Nucleic acid dioxygenase ALKBH1; Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. Requires molecular oxygen, alpha-ketoglutarate and iron. A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment (By similarity). Mainly acts as a tRNA demethylase by removing N(1)- methyladenine from various tRNAs, with a preference for N(1)- methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs. Act [...] "},{"id":"ENSMUSP00000106369","abundance":0.914,"rank":11382,"name":"Fam90a1a","annotation":"Family with sequence similarity 90, member A1A."},{"id":"ENSMUSP00000044185","abundance":0.914,"rank":11383,"name":"Slc9a8","annotation":"Sodium/hydrogen exchanger 8; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (By similarity); Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family."},{"id":"ENSMUSP00000034460","abundance":0.913,"rank":11384,"name":"Cog2","annotation":"Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function."},{"id":"ENSMUSP00000023482","abundance":0.913,"rank":11385,"name":"B4galt4","annotation":"Beta-1,4-galactosyltransferase 4; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the glycosyltransferase 7 family."},{"id":"ENSMUSP00000052179","abundance":0.912,"rank":11386,"name":"Bbs12","annotation":"Bardet-Biedl syndrome 12 protein homolog; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation."},{"id":"ENSMUSP00000070504","abundance":0.912,"rank":11387,"name":"Haus6","annotation":"HAUS augmin-like complex, subunit 6."},{"id":"ENSMUSP00000080337","abundance":0.912,"rank":11388,"name":"Mettl15","annotation":"Probable methyltransferase-like protein 15; Probable S-adenosyl-L-methionine-dependent methyltransferase."},{"id":"ENSMUSP00000100973","abundance":0.912,"rank":11389,"name":"Dot1l","annotation":"Histone-lysine N-methyltransferase, H3 lysine-79 specific."},{"id":"ENSMUSP00000044693","abundance":0.912,"rank":11390,"name":"Palmd","annotation":"Palmdelphin; Belongs to the paralemmin family."},{"id":"ENSMUSP00000038142","abundance":0.911,"rank":11391,"name":"Slc9a3","annotation":"Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family."},{"id":"ENSMUSP00000112314","abundance":0.911,"rank":11392,"name":"Barx2","annotation":"Homeobox protein BarH-like 2; Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia; Belongs to the BAR homeobox family."},{"id":"ENSMUSP00000034612","abundance":0.91,"rank":11393,"name":"Ddx25","annotation":"ATP-dependent RNA helicase DDX25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development."},{"id":"ENSMUSP00000025800","abundance":0.91,"rank":11394,"name":"Pip5k1b","annotation":"Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; Participates in the biosynthesis of phosphatidylinositol 4,5- bisphosphate. Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of PLD2. Together with PIP5K1A is required after stimulation of G-protein coupled receptors for stable platelet adhesion."},{"id":"ENSMUSP00000099552","abundance":0.91,"rank":11395,"name":"Nsrp1","annotation":"Nuclear speckle splicing regulatory protein 1; RNA-binding protein that mediates pre-mRNA alternative splicing regulation; Belongs to the NSRP1 family."},{"id":"ENSMUSP00000139768","abundance":0.909,"rank":11396,"name":"Gm13283","annotation":"Predicted gene 13283."},{"id":"ENSMUSP00000027362","abundance":0.909,"rank":11397,"name":"Plcd4","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration [...] "},{"id":"ENSMUSP00000100064","abundance":0.909,"rank":11398,"name":"Cngb3","annotation":"Cyclic nucleotide-gated cation channel beta-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced  [...] "},{"id":"ENSMUSP00000026472","abundance":0.909,"rank":11399,"name":"Inhbc","annotation":"Inhibin beta C chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000107548","abundance":0.909,"rank":11400,"name":"Shld2","annotation":"Shieldin complex subunit 2; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres."},{"id":"ENSMUSP00000086252","abundance":0.909,"rank":11401,"name":"Klra2","annotation":"Killer cell lectin-like receptor 2; Receptor on natural killer (NK) cells for class I MHC."},{"id":"ENSMUSP00000035338","abundance":0.908,"rank":11402,"name":"Tdrd6","annotation":"Tudor domain-containing protein 6; Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and spliceosome maturation  (By similarity). Essential for RNA-dependent helicase UPF1 localization to chromatoid body, for UPF1-UPF2 and UPF1-DDX4 interactions which are required for mRNA degradation, using the extended 3' UTR-triggered nonsense-mediated mRNA decay (NMD) pathway. Involved in spliceosome maturatio [...] "},{"id":"ENSMUSP00000042303","abundance":0.908,"rank":11403,"name":"Dsc1","annotation":"Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues."},{"id":"ENSMUSP00000084823","abundance":0.908,"rank":11404,"name":"B3galt4","annotation":"Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis. Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000059461","abundance":0.908,"rank":11405,"name":"Krtap5-4","annotation":"Keratin-associated protein 5-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins."},{"id":"ENSMUSP00000058455","abundance":0.907,"rank":11406,"name":"St7l","annotation":"Suppressor of tumorigenicity 7 protein-like."},{"id":"ENSMUSP00000069055","abundance":0.907,"rank":11407,"name":"Capn12","annotation":"Calpain-12; Calcium-regulated non-lysosomal thiol-protease."},{"id":"ENSMUSP00000033723","abundance":0.907,"rank":11408,"name":"Syap1","annotation":"Synapse-associated protein 1; Plays a role in adipocyte differentiation by promoting mTORC2-mediated phosphorylation of AKT1 at 'Ser-473' after growth factor stimulation."},{"id":"ENSMUSP00000051316","abundance":0.906,"rank":11409,"name":"Kctd21","annotation":"BTB/POZ domain-containing protein KCTD21; Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB)."},{"id":"ENSMUSP00000137696","abundance":0.906,"rank":11410,"name":"Gm6614","annotation":"Solute carrier organic anion transporter family member."},{"id":"ENSMUSP00000026227","abundance":0.906,"rank":11411,"name":"Twnk","annotation":"Twinkle protein, mitochondrial; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function infered to be critical for lifetime maintenance of mtDNA integrity. May be a key regulator of mtDNA copy number in mammals."},{"id":"ENSMUSP00000080325","abundance":0.906,"rank":11412,"name":"Sh3pxd2a","annotation":"SH3 and PX domain-containing protein 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide (By similarity)."},{"id":"ENSMUSP00000077685","abundance":0.906,"rank":11413,"name":"BC051142","annotation":"Testis specific basic protein."},{"id":"ENSMUSP00000137377","abundance":0.905,"rank":11414,"name":"Fam177a2","annotation":"Family with sequence similarity 177 member A2."},{"id":"ENSMUSP00000137299","abundance":0.905,"rank":11415,"name":"Fam177a","annotation":"Protein FAM177A1; Belongs to the FAM177 family."},{"id":"ENSMUSP00000028328","abundance":0.905,"rank":11416,"name":"Entpd2","annotation":"Ectonucleoside triphosphate diphosphohydrolase 2; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent (By similarity)."},{"id":"ENSMUSP00000054702","abundance":0.905,"rank":11417,"name":"Prr12","annotation":"Proline-rich protein 12."},{"id":"ENSMUSP00000065423","abundance":0.904,"rank":11418,"name":"Clec16a","annotation":"Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health."},{"id":"ENSMUSP00000052856","abundance":0.904,"rank":11419,"name":"Rnf7","annotation":"RING-box protein 2; Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription (By similarity). CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets (By similarity). Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity  [...] "},{"id":"ENSMUSP00000116057","abundance":0.904,"rank":11420,"name":"Rfx6","annotation":"DNA-binding protein RFX6; Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide- producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by [...] "},{"id":"ENSMUSP00000057928","abundance":0.903,"rank":11421,"name":"Trim10","annotation":"Tripartite motif-containing protein 10; Seems to play an important role in erythropoiesis; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000027279","abundance":0.903,"rank":11422,"name":"Nabp1","annotation":"SOSS complex subunit B2; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] "},{"id":"ENSMUSP00000098634","abundance":0.903,"rank":11423,"name":"Tmprss11a","annotation":"Transmembrane protease serine 11A; Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000055746","abundance":0.903,"rank":11424,"name":"Qrfp","annotation":"Orexigenic neuropeptide QRFP; Stimulates feeding and grooming behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland. Belongs to the RFamide neuropeptide family."},{"id":"ENSMUSP00000061610","abundance":0.903,"rank":11425,"name":"Eogt","annotation":"EGF domain-specific O-linked N-acetylglucosamine transferase; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains. Belongs to the glycosyltransferase 61 family."},{"id":"ENSMUSP00000032926","abundance":0.903,"rank":11426,"name":"Tmem219","annotation":"Insulin-like growth factor-binding protein 3 receptor; Cell death receptor specific for IGFBP3, may mediate caspase- 8-dependent apoptosis upon ligand binding."},{"id":"ENSMUSP00000094192","abundance":0.902,"rank":11427,"name":"Btg1c","annotation":"BTG anti-proliferation factor 1C."},{"id":"ENSMUSP00000150722","abundance":0.902,"rank":11428,"name":"Robo4","annotation":"Roundabout homolog 4; Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organization and function (By similarity); Belongs to the immunoglobulin superfamily. ROBO family."},{"id":"ENSMUSP00000004381","abundance":0.902,"rank":11429,"name":"Lpcat3","annotation":"Lysophospholipid acyltransferase 5; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity), and the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidyl [...] "},{"id":"ENSMUSP00000089803","abundance":0.902,"rank":11430,"name":"Gm10271","annotation":"Predicted gene 10271."},{"id":"ENSMUSP00000029270","abundance":0.902,"rank":11431,"name":"Ccna2","annotation":"Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle."},{"id":"ENSMUSP00000027233","abundance":0.902,"rank":11432,"name":"Slc9a4","annotation":"Sodium/hydrogen exchanger 4; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained int [...] "},{"id":"ENSMUSP00000070494","abundance":0.901,"rank":11433,"name":"Cbln3","annotation":"Cerebellin-3; May be involved in synaptic functions in the CNS."},{"id":"ENSMUSP00000099558","abundance":0.901,"rank":11434,"name":"Gemin4","annotation":"Gem (Nuclear organelle) associated protein 4."},{"id":"ENSMUSP00000021942","abundance":0.901,"rank":11435,"name":"Prelid1","annotation":"PRELI domain-containing protein 1, mitochondrial; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4- induc [...] "},{"id":"ENSMUSP00000064366","abundance":0.901,"rank":11436,"name":"Klf1","annotation":"Krueppel-like factor 1; Transcription regulator of erythrocyte development. Binds to the CACCC box in the beta-globin gene promoter and activates transcription. Probably serves as a general switch factor for erythroid development. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation."},{"id":"ENSMUSP00000006856","abundance":0.9,"rank":11437,"name":"Pola1","annotation":"DNA polymerase alpha catalytic subunit; Catalytic subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, a regulatory subunit POLA2 and two primase subunits PRIM1 and PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA p [...] "},{"id":"ENSMUSP00000095070","abundance":0.9,"rank":11438,"name":"Ifi213","annotation":"Interferon-activated gene 213."},{"id":"ENSMUSP00000119781","abundance":0.9,"rank":11439,"name":"Zfp866","annotation":"Zinc finger protein 866."},{"id":"ENSMUSP00000043764","abundance":0.899,"rank":11440,"name":"Ephx4","annotation":"Epoxide hydrolase 4."},{"id":"ENSMUSP00000107539","abundance":0.899,"rank":11441,"name":"Mmrn2","annotation":"Multimerin-2; Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA."},{"id":"ENSMUSP00000015017","abundance":0.899,"rank":11442,"name":"Surf2","annotation":"Surfeit locus protein 2; Belongs to the SURF2 family."},{"id":"ENSMUSP00000139062","abundance":0.899,"rank":11443,"name":"Btg1b","annotation":"BTG anti-proliferation factor 1B."},{"id":"ENSMUSP00000027988","abundance":0.899,"rank":11444,"name":"Ccdc3","annotation":"Coiled-coil domain-containing protein 3; Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells."},{"id":"ENSMUSP00000030427","abundance":0.898,"rank":11445,"name":"Eloa","annotation":"Elongin-A; SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)."},{"id":"ENSMUSP00000141786","abundance":0.898,"rank":11446,"name":"Gpatch4","annotation":"G patch domain-containing protein 4."},{"id":"ENSMUSP00000125662","abundance":0.898,"rank":11447,"name":"Hps1","annotation":"Hermansky-Pudlak syndrome 1 protein homolog; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38."},{"id":"ENSMUSP00000008090","abundance":0.898,"rank":11448,"name":"Phox2a","annotation":"Paired mesoderm homeobox protein 2A; May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype (By similarity); Belongs to the paired homeobox family."},{"id":"ENSMUSP00000027877","abundance":0.898,"rank":11449,"name":"Kifap3","annotation":"Kinesin-associated protein 3; Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex."},{"id":"ENSMUSP00000020931","abundance":0.898,"rank":11450,"name":"Smc6","annotation":"Structural maintenance of chromosomes protein 6; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity)."},{"id":"ENSMUSP00000022682","abundance":0.898,"rank":11451,"name":"Sorbs3","annotation":"Vinexin; Promotes up-regulation of actin stress fiber formation."},{"id":"ENSMUSP00000030971","abundance":0.897,"rank":11452,"name":"Adgra3","annotation":"Adhesion G protein-coupled receptor A3; Orphan receptor that may have a role in planar cell polarity pathway."},{"id":"ENSMUSP00000141564","abundance":0.897,"rank":11453,"name":"Dusp27","annotation":"Inactive dual specificity phosphatase 27; May be required for myofiber maturation. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000047372","abundance":0.896,"rank":11454,"name":"Lonrf2","annotation":"LON peptidase N-terminal domain and ring finger 2."},{"id":"ENSMUSP00000080257","abundance":0.896,"rank":11455,"name":"Kcnd2","annotation":"Potassium voltage-gated channel subfamily D member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in rodent heart. Mediates the major part of the dendritic A-type current I(SA) in brain neurons. This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of a [...] "},{"id":"ENSMUSP00000035486","abundance":0.896,"rank":11456,"name":"Ccs","annotation":"Copper chaperone for superoxide dismutase; Delivers copper to copper zinc superoxide dismutase (SOD1)."},{"id":"ENSMUSP00000133846","abundance":0.895,"rank":11457,"name":"Nat8f6","annotation":"N-acetyltransferase family 8 member 3; Has histone acetyltransferase activity in vitro, with specificity for histone H4."},{"id":"ENSMUSP00000111587","abundance":0.894,"rank":11458,"name":"LOC102638047","annotation":"Sp110 nuclear body protein-like."},{"id":"ENSMUSP00000064524","abundance":0.894,"rank":11459,"name":"Fam216b","annotation":"Protein FAM216B; Belongs to the FAM216 family."},{"id":"ENSMUSP00000074837","abundance":0.894,"rank":11460,"name":"Pard3b","annotation":"Partitioning defective 3 homolog B; Putative adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions (By similarity); Belongs to the PAR3 family."},{"id":"ENSMUSP00000019447","abundance":0.893,"rank":11461,"name":"Psmc3ip","annotation":"Homologous-pairing protein 2 homolog; Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double- strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protei [...] "},{"id":"ENSMUSP00000022059","abundance":0.893,"rank":11462,"name":"Ahrr","annotation":"Aryl hydrocarbon receptor repressor; Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site."},{"id":"ENSMUSP00000006101","abundance":0.893,"rank":11463,"name":"Itgae","annotation":"Integrin alpha-E heavy chain; Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall."},{"id":"ENSMUSP00000121493","abundance":0.893,"rank":11464,"name":"Spryd3","annotation":"SPRY domain-containing 3."},{"id":"ENSMUSP00000150471","abundance":0.893,"rank":11465,"name":"Olfr944","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000115645","abundance":0.892,"rank":11466,"name":"Msto1","annotation":"Protein misato homolog 1; Involved in the regulation of mitochondrial distribution and morphology. Required for mitochondrial fusion and mitochondrial network formation."},{"id":"ENSMUSP00000070394","abundance":0.892,"rank":11467,"name":"Hs6st3","annotation":"Heparan-sulfate 6-O-sulfotransferase 3; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate."},{"id":"ENSMUSP00000042867","abundance":0.891,"rank":11468,"name":"Wnt8b","annotation":"Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus; Belongs to the Wnt family."},{"id":"ENSMUSP00000022331","abundance":0.891,"rank":11469,"name":"Opn4","annotation":"Melanopsin; Photoreceptor required for regulation of circadian rhythm. Contributes to pupillar reflex and other non-image forming responses to light. May be able to isomerize covalently bound all-trans retinal back to 11-cis retinal."},{"id":"ENSMUSP00000023431","abundance":0.891,"rank":11470,"name":"Tbc1d23","annotation":"TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles. Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly t [...] "},{"id":"ENSMUSP00000153300","abundance":0.891,"rank":11471,"name":"Treml1","annotation":"Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response."},{"id":"ENSMUSP00000046967","abundance":0.891,"rank":11472,"name":"Midn","annotation":"Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (By similarity)."},{"id":"ENSMUSP00000045007","abundance":0.891,"rank":11473,"name":"Fthl17a","annotation":"Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation."},{"id":"ENSMUSP00000059686","abundance":0.891,"rank":11474,"name":"Zfp456","annotation":"Zinc finger protein 456."},{"id":"ENSMUSP00000100007","abundance":0.891,"rank":11475,"name":"Hus1b","annotation":"Checkpoint protein HUS1B."},{"id":"ENSMUSP00000108327","abundance":0.891,"rank":11476,"name":"Lrrc8b","annotation":"Volume-regulated anion channel subunit LRRC8B; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition."},{"id":"ENSMUSP00000069161","abundance":0.891,"rank":11477,"name":"Tmem158","annotation":"Transmembrane protein 158; Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide; Belongs to the TMEM158 family."},{"id":"ENSMUSP00000021290","abundance":0.89,"rank":11478,"name":"Rcvrn","annotation":"Recoverin; Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions. In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells. Improves rod photoreceptor sensitivi [...] "},{"id":"ENSMUSP00000103772","abundance":0.89,"rank":11479,"name":"Mmp28","annotation":"Matrix metallopeptidase 28 (epilysin)."},{"id":"ENSMUSP00000001711","abundance":0.89,"rank":11480,"name":"Hoxc6","annotation":"Homeobox protein Hox-C6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis."},{"id":"ENSMUSP00000104906","abundance":0.89,"rank":11481,"name":"Slc2a13","annotation":"Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers."},{"id":"ENSMUSP00000146362","abundance":0.89,"rank":11482,"name":"Sesn3","annotation":"Sestrin-3; May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity); Belongs to the sestrin family."},{"id":"ENSMUSP00000071956","abundance":0.89,"rank":11483,"name":"Lrrc40","annotation":"Leucine-rich repeat-containing protein 40."},{"id":"ENSMUSP00000027643","abundance":0.889,"rank":11484,"name":"Atp6v1g3","annotation":"V-type proton ATPase subunit G 3; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells."},{"id":"ENSMUSP00000142196","abundance":0.889,"rank":11485,"name":"Pex5l","annotation":"PEX5-related protein; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence. Belongs to the peroxisomal targeting signal receptor family."},{"id":"ENSMUSP00000055326","abundance":0.889,"rank":11486,"name":"Kctd8","annotation":"BTB/POZ domain-containing protein KCTD8; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization."},{"id":"ENSMUSP00000112765","abundance":0.889,"rank":11487,"name":"Btc","annotation":"Probetacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells."},{"id":"ENSMUSP00000063879","abundance":0.889,"rank":11488,"name":"Fbrsl1","annotation":"Fibrosin-like 1."},{"id":"ENSMUSP00000097599","abundance":0.889,"rank":11489,"name":"Pitpnm1","annotation":"Membrane-associated phosphatidylinositol transfer protein 1; Regulates RHOA activity, and plays a role in cytoskeleton remodeling. Necessary for normal completion of cytokinesis. Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus. Binds phosphatidyl inositol phosphates (in vitro). May catalyze the transfer of phosphatidylinositol and phosphatidylcholine between membranes (By similarity). Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus. Required for protein export from the endoplasmic reticulum and the Golg [...] "},{"id":"ENSMUSP00000035523","abundance":0.889,"rank":11490,"name":"1700003F12Rik","annotation":"RIKEN cDNA 1700003F12 gene."},{"id":"ENSMUSP00000098220","abundance":0.889,"rank":11491,"name":"9130401M01Rik","annotation":"Uncharacterized protein C8orf76 homolog."},{"id":"ENSMUSP00000034382","abundance":0.889,"rank":11492,"name":"Zfp90","annotation":"Zinc finger protein 90; Inhibits the transcriptional repressor activity of REST by inhibiting its binding to DNA, thereby derepressing transcription of REST target genes."},{"id":"ENSMUSP00000047285","abundance":0.888,"rank":11493,"name":"Pak7","annotation":"Serine/threonine-protein kinase PAK 5; Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphoryla [...] "},{"id":"ENSMUSP00000037980","abundance":0.888,"rank":11494,"name":"Cldnd2","annotation":"Claudin domain-containing protein 2."},{"id":"ENSMUSP00000136918","abundance":0.888,"rank":11495,"name":"Rad21l","annotation":"Double-strand-break repair protein rad21-like protein 1; Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I. Not required for meiosis in females in  [...] "},{"id":"ENSMUSP00000068238","abundance":0.887,"rank":11496,"name":"1700001K19Rik","annotation":"RIKEN cDNA 1700001K19 gene."},{"id":"ENSMUSP00000064120","abundance":0.887,"rank":11497,"name":"Vmac","annotation":"Vimentin-type intermediate filament-associated coiled-coil protein."},{"id":"ENSMUSP00000002765","abundance":0.886,"rank":11498,"name":"Prkd1","annotation":"Serine/threonine-protein kinase D1; Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory res [...] "},{"id":"ENSMUSP00000131932","abundance":0.886,"rank":11499,"name":"Oser1","annotation":"Oxidative stress-responsive serine-rich protein 1."},{"id":"ENSMUSP00000060527","abundance":0.886,"rank":11500,"name":"Olfr683","annotation":"Olfactory receptor MOR40-1."},{"id":"ENSMUSP00000062766","abundance":0.885,"rank":11501,"name":"Nupl2","annotation":"Nucleoporin NUP42; Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm."},{"id":"ENSMUSP00000144272","abundance":0.885,"rank":11502,"name":"Eno4","annotation":"Enolase 4; Required for sperm motility, function and male fertility. May be involved in the normal assembly of the sperm fibrous sheath and provides most of the enolase activity in sperm."},{"id":"ENSMUSP00000141487","abundance":0.884,"rank":11503,"name":"Larp1b","annotation":"La ribonucleoprotein domain family, member 1B."},{"id":"ENSMUSP00000033539","abundance":0.884,"rank":11504,"name":"F8","annotation":"Coagulation factor VIII; Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa."},{"id":"ENSMUSP00000025981","abundance":0.884,"rank":11505,"name":"Tctn3","annotation":"Tectonic-3; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation (By similarity). Necessary for signal transduction through the sonic hedgehog (Shh) signaling pathway."},{"id":"ENSMUSP00000046526","abundance":0.884,"rank":11506,"name":"Rsph6a","annotation":"Radial spoke head protein 6 homolog A."},{"id":"ENSMUSP00000038613","abundance":0.884,"rank":11507,"name":"Jcad","annotation":"Junctional protein associated with coronary artery disease."},{"id":"ENSMUSP00000076594","abundance":0.883,"rank":11508,"name":"2810006K23Rik","annotation":"Probable peptide chain release factor C12orf65 homolog, mitochondrial; May act as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion. May help rescuing stalled mitoribosomes during translation (By similarity)."},{"id":"ENSMUSP00000021866","abundance":0.883,"rank":11509,"name":"Riok1","annotation":"Serine/threonine-protein kinase RIO1; Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (By similarity). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its [...] "},{"id":"ENSMUSP00000047419","abundance":0.883,"rank":11510,"name":"Ly6d","annotation":"Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification."},{"id":"ENSMUSP00000036240","abundance":0.883,"rank":11511,"name":"Galnt11","annotation":"Polypeptide N-acetylgalactosaminyltransferase 11; Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O- glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme a [...] "},{"id":"ENSMUSP00000138022","abundance":0.883,"rank":11512,"name":"Raet1e","annotation":"Retinoic acid early-inducible protein 1-epsilon; Acts as a ligand for KLRK1; Belongs to the NKG2D ligand family."},{"id":"ENSMUSP00000125121","abundance":0.883,"rank":11513,"name":"Sh2d1b2","annotation":"SH2 domain-containing protein 1B2; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family. In SLAM signaling may cooperate with Sh2d1a/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through Cd244/2b4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of Cd244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter found also by triggering Klra4 and Klrk1 ne [...] "},{"id":"ENSMUSP00000075672","abundance":0.883,"rank":11514,"name":"Phldb2","annotation":"Pleckstrin homology-like domain family B member 2; Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane."},{"id":"ENSMUSP00000093173","abundance":0.883,"rank":11515,"name":"Cog8","annotation":"Conserved oligomeric Golgi complex subunit 8; Required for normal Golgi function."},{"id":"ENSMUSP00000042808","abundance":0.882,"rank":11516,"name":"Npepl1","annotation":"Probable aminopeptidase NPEPL1; Probably catalyzes the removal of unsubstituted N-terminal amino acids from various peptides; Belongs to the peptidase M17 family."},{"id":"ENSMUSP00000013497","abundance":0.882,"rank":11517,"name":"4931406B18Rik","annotation":"RIKEN cDNA 4931406B18 gene."},{"id":"ENSMUSP00000057103","abundance":0.882,"rank":11518,"name":"Frmd7","annotation":"FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability."},{"id":"ENSMUSP00000019722","abundance":0.882,"rank":11519,"name":"Ubxn6","annotation":"UBX domain-containing protein 6; May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes."},{"id":"ENSMUSP00000134266","abundance":0.882,"rank":11520,"name":"Wdr81","annotation":"WD repeat-containing protein 81; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic [...] "},{"id":"ENSMUSP00000023754","abundance":0.881,"rank":11521,"name":"Aqp6","annotation":"Aquaporin-6; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism."},{"id":"ENSMUSP00000125096","abundance":0.881,"rank":11522,"name":"Ecel1","annotation":"Endothelin-converting enzyme-like 1; May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides; Belongs to the peptidase M13 family."},{"id":"ENSMUSP00000109914","abundance":0.881,"rank":11523,"name":"Mpp4","annotation":"MAGUK p55 subfamily member 4; May play a role in retinal photoreceptors development. Belongs to the MAGUK family."},{"id":"ENSMUSP00000093255","abundance":0.88,"rank":11524,"name":"Zscan10","annotation":"Zinc finger and SCAN domain-containing protein 10; Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4."},{"id":"ENSMUSP00000109967","abundance":0.88,"rank":11525,"name":"Tex28","annotation":"Testis-expressed 28."},{"id":"ENSMUSP00000071464","abundance":0.88,"rank":11526,"name":"Dach1","annotation":"Dachshund homolog 1; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCO [...] "},{"id":"ENSMUSP00000022185","abundance":0.88,"rank":11527,"name":"F2rl1","annotation":"Proteinase-activated receptor 2; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF- kappaB and Rho. Can also be transactivated by cleaved F2r/Par1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistical [...] "},{"id":"ENSMUSP00000107439","abundance":0.879,"rank":11528,"name":"Neurl1a","annotation":"E3 ubiquitin-protein ligase NEURL1; Plays a role in hippocampal-dependent synaptic plasticity, learning and memory. Involved in the formation of spines and functional synaptic contacts by modulating the translational activity of the cytoplasmic polyadenylation element-binding protein CPEB3. Promotes ubiquitination of CPEB3, and hence induces CPEB3-dependent mRNA translation activation of glutamate receptor GRIA1 and GRIA2. Can function as an E3 ubiquitin-protein ligase to activate monoubiquitination of JAG1 (in vitro), thereby regulating the Notch pathway. Acts as a tumor suppressor; i [...] "},{"id":"ENSMUSP00000020284","abundance":0.879,"rank":11529,"name":"Tysnd1","annotation":"Peroxisomal leader peptide-processing protease, 10 kDa form; Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids (By similarity); Belongs to the peptidase S1B family."},{"id":"ENSMUSP00000055602","abundance":0.879,"rank":11530,"name":"Zfp106","annotation":"Zinc finger protein 106; RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism."},{"id":"ENSMUSP00000059848","abundance":0.878,"rank":11531,"name":"Ccdc17","annotation":"Coiled-coil domain-containing protein 17."},{"id":"ENSMUSP00000028844","abundance":0.878,"rank":11532,"name":"Sppl2a","annotation":"Signal peptide peptidase-like 2A; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). May play a role in the regulation of innate and [...] "},{"id":"ENSMUSP00000014642","abundance":0.877,"rank":11533,"name":"Ankrd52","annotation":"Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates."},{"id":"ENSMUSP00000095675","abundance":0.877,"rank":11534,"name":"Palb2","annotation":"Partner and localizer of BRCA2; Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombinat [...] "},{"id":"ENSMUSP00000018491","abundance":0.877,"rank":11535,"name":"Zkscan6","annotation":"Zinc finger protein 18; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000005103","abundance":0.877,"rank":11536,"name":"Nfe2l3","annotation":"Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Belongs to the bZIP family. CNC subfamily."},{"id":"ENSMUSP00000082051","abundance":0.876,"rank":11537,"name":"Fbxw16","annotation":"F-box and WD-40 domain protein 16."},{"id":"ENSMUSP00000034911","abundance":0.875,"rank":11538,"name":"Tinag","annotation":"Tubulo-interstitial nephritis antigen; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000137082","abundance":0.875,"rank":11539,"name":"Fsbp","annotation":"Fibrinogen silencer-binding protein; Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1."},{"id":"ENSMUSP00000050684","abundance":0.875,"rank":11540,"name":"Patz1","annotation":"POZ (BTB) and AT hook-containing zinc finger 1."},{"id":"ENSMUSP00000106128","abundance":0.875,"rank":11541,"name":"Wdr95","annotation":"WD40 repeat domain 95."},{"id":"ENSMUSP00000080973","abundance":0.874,"rank":11542,"name":"Sult4a1","annotation":"Sulfotransferase 4A1; Atypical sulfotransferase family member with very low affinity for 3'-phospho-5'-adenylyl sulfate (PAPS) and very low catalytic activity towards L-triiodothyronine, thyroxine, estrone, p- nitrophenol, 2-naphthylamine, and 2-beta-naphthol. May have a role in the metabolism of drugs and neurotransmitters in the CNS."},{"id":"ENSMUSP00000102986","abundance":0.874,"rank":11543,"name":"Kcnh4","annotation":"Potassium Voltage-gated channel, subfamily H (Eag-related), member 4."},{"id":"ENSMUSP00000046329","abundance":0.874,"rank":11544,"name":"Myo3a","annotation":"Myosin-IIIa; Probable actin-based motor with a protein kinase activity. Probably plays a role in vision and hearing (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the  [...] "},{"id":"ENSMUSP00000013995","abundance":0.874,"rank":11545,"name":"Abca4","annotation":"Retinal-specific phospholipid-transporting ATPase ABCA4; Catalyzes the translocation of specific phospholipids from the extracellular/lumenal to the cytoplasmic leaflet of membrane coupled to the hydrolysis of ATP. Transports preferentially phosphatidylethanolamine. In the visual cycle, acts as an inward- directed retinoid flipase, retinoid substrates imported by ABCA4 from the extracellular or intradiscal (rod) membrane surfaces to the cytoplasmic membrane surface are all-trans-retinaldehyde (ATR) and N- retinyl-phosphatidyl-ethanolamine (NR-PE). Once transported to the cytoplasmic su [...] "},{"id":"ENSMUSP00000056227","abundance":0.873,"rank":11546,"name":"Jmjd1c","annotation":"Probable JmjC domain-containing histone demethylation protein 2C; Probable histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May be involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes (By similarity)."},{"id":"ENSMUSP00000043724","abundance":0.873,"rank":11547,"name":"Rcsd1","annotation":"CapZ-interacting protein; Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly."},{"id":"ENSMUSP00000045269","abundance":0.873,"rank":11548,"name":"Oma1","annotation":"Metalloendopeptidase OMA1, mitochondrial; Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase [...] "},{"id":"ENSMUSP00000127711","abundance":0.873,"rank":11549,"name":"Prr23a1","annotation":"Proline-rich 23A, member 1."},{"id":"ENSMUSP00000092432","abundance":0.872,"rank":11550,"name":"Stk32b","annotation":"Serine/threonine-protein kinase 32B."},{"id":"ENSMUSP00000025241","abundance":0.871,"rank":11551,"name":"Ercc3","annotation":"General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] "},{"id":"ENSMUSP00000109901","abundance":0.871,"rank":11552,"name":"Peak1","annotation":"Inactive tyrosine-protein kinase PEAK1; Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling."},{"id":"ENSMUSP00000068158","abundance":0.871,"rank":11553,"name":"Gtsf2","annotation":"Gametocyte-specific factor 2."},{"id":"ENSMUSP00000023364","abundance":0.871,"rank":11554,"name":"Pla2g10","annotation":"Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids."},{"id":"ENSMUSP00000091437","abundance":0.871,"rank":11555,"name":"Qrich2","annotation":"Glutamine-rich protein 2; Has an essential role in the formation of sperm flagella and flagellar structure maintainance. It acts as a suppressor of ubiquitination and degradation of proteins involved in flagellar development and motility."},{"id":"ENSMUSP00000015841","abundance":0.871,"rank":11556,"name":"Setdb1","annotation":"Histone-lysine N-methyltransferase SETDB1; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys- 9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9'  [...] "},{"id":"ENSMUSP00000158902","abundance":0.87,"rank":11557,"name":"ENSMUSP00000158902","annotation":"Uncharacterized protein."},{"id":"ENSMUSP00000077091","abundance":0.87,"rank":11558,"name":"Haghl","annotation":"Hydroxyacylglutathione hydrolase-like protein; Hydrolase acting on ester bonds."},{"id":"ENSMUSP00000108039","abundance":0.87,"rank":11559,"name":"Slc38a11","annotation":"Putative sodium-coupled neutral amino acid transporter 11; Putative sodium-dependent amino acid/proton antiporter."},{"id":"ENSMUSP00000147092","abundance":0.87,"rank":11560,"name":"Nkpd1","annotation":"NTPase KAP family P-loop domain-containing protein 1."},{"id":"ENSMUSP00000083106","abundance":0.87,"rank":11561,"name":"Nlrp9c","annotation":"NACHT, LRR and PYD domains-containing protein 9C; May be involved in inflammation; Belongs to the NLRP family."},{"id":"ENSMUSP00000124569","abundance":0.869,"rank":11562,"name":"Slc37a2","annotation":"Glucose-6-phosphate exchanger SLC37A2; Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels. Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family."},{"id":"ENSMUSP00000020804","abundance":0.869,"rank":11563,"name":"Gdpd1","annotation":"Lysophospholipase D GDPD1; Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Shows a preference for 1-O-alkyl- sn-glycero-3-phosphocholine (lyso-PAF), lysophosphatidylethanolamine (lyso-PE) and lysophosphatidylcholine (lyso-PC). May be involved in bioactive N-acylethanolamine biosynthesis. Does not display glycerophosphodiester phosphodiesterase activity, since it cannot hydrolyze either glycerophosphoinositol or glycerophosphocholine."},{"id":"ENSMUSP00000087694","abundance":0.869,"rank":11564,"name":"March6","annotation":"E3 ubiquitin-protein ligase MARCHF6; E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1; Belongs to the DOA10/MARCHF6 family."},{"id":"ENSMUSP00000092645","abundance":0.869,"rank":11565,"name":"Zbtb43","annotation":"Zinc finger and BTB domain-containing protein 43; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000011152","abundance":0.869,"rank":11566,"name":"Mcoln2","annotation":"Mucolipin-2; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity. May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (By similarity). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells. In the innate immune response, may play a role in the regulation of chemokine sec [...] "},{"id":"ENSMUSP00000134273","abundance":0.868,"rank":11567,"name":"Ttc6","annotation":"Tetratricopeptide repeat domain 6."},{"id":"ENSMUSP00000137385","abundance":0.868,"rank":11568,"name":"Fastkd5","annotation":"FAST kinase domain-containing protein 5, mitochondrial; Plays an important role in the processing of non-canonical mitochondrial mRNA precursors; Belongs to the FAST kinase family."},{"id":"ENSMUSP00000131830","abundance":0.868,"rank":11569,"name":"Cnnm1","annotation":"Metal transporter CNNM1; Probable metal transporter; Belongs to the ACDP family."},{"id":"ENSMUSP00000089212","abundance":0.868,"rank":11570,"name":"Wnk2","annotation":"Serine/threonine-protein kinase WNK2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulatio [...] "},{"id":"ENSMUSP00000106076","abundance":0.868,"rank":11571,"name":"Fam227b","annotation":"Protein FAM227B; Belongs to the FAM227 family."},{"id":"ENSMUSP00000123773","abundance":0.868,"rank":11572,"name":"2700081O15Rik","annotation":"Uncharacterized protein C11orf95 homolog."},{"id":"ENSMUSP00000158934","abundance":0.868,"rank":11573,"name":"Arl5b","annotation":"ADP-ribosylation factor-like protein 5B; Binds and exchanges GTP and GDP."},{"id":"ENSMUSP00000028888","abundance":0.868,"rank":11574,"name":"Tgm6","annotation":"Transglutaminase 6."},{"id":"ENSMUSP00000093449","abundance":0.867,"rank":11575,"name":"Cdhr3","annotation":"Cadherin-related family member 3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."},{"id":"ENSMUSP00000052919","abundance":0.867,"rank":11576,"name":"Bend6","annotation":"BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis."},{"id":"ENSMUSP00000055255","abundance":0.866,"rank":11577,"name":"Krt9","annotation":"Keratin, type I cytoskeletal 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly (By similarity). Plays an essential role in the correct development of sperm; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000025430","abundance":0.866,"rank":11578,"name":"Setbp1","annotation":"SET-binding protein."},{"id":"ENSMUSP00000031273","abundance":0.866,"rank":11579,"name":"Cds1","annotation":"Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (By similarity). Belongs to the CDS family."},{"id":"ENSMUSP00000117040","abundance":0.866,"rank":11580,"name":"Ppargc1a","annotation":"Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in  [...] "},{"id":"ENSMUSP00000073618","abundance":0.866,"rank":11581,"name":"Sipa1","annotation":"Signal-induced proliferation-associated protein 1; GTPase activator for the nuclear Ras-related regulatory proteins Rap1, Rsr1 and Ran in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression."},{"id":"ENSMUSP00000071017","abundance":0.865,"rank":11582,"name":"Rnf144b","annotation":"E3 ubiquitin-protein ligase RNF144B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin- dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death; But, it is not an anti-apoptotic protein per se (By s [...] "},{"id":"ENSMUSP00000022013","abundance":0.865,"rank":11583,"name":"Adcy2","annotation":"Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family."},{"id":"ENSMUSP00000122497","abundance":0.865,"rank":11584,"name":"Arhgap21","annotation":"Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity)."},{"id":"ENSMUSP00000089805","abundance":0.865,"rank":11585,"name":"Ptprb","annotation":"Receptor-type tyrosine-protein phosphatase beta; Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growt [...] "},{"id":"ENSMUSP00000156068","abundance":0.865,"rank":11586,"name":"A630089N07Rik","annotation":"RIKEN cDNA A630089N07 gene."},{"id":"ENSMUSP00000039312","abundance":0.864,"rank":11587,"name":"Gpr63","annotation":"Probable G-protein coupled receptor 63; Orphan receptor. May play a role in brain function."},{"id":"ENSMUSP00000052496","abundance":0.864,"rank":11588,"name":"Hoxb8","annotation":"Homeobox protein Hox-B8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis."},{"id":"ENSMUSP00000086900","abundance":0.863,"rank":11589,"name":"Zdhhc20","annotation":"Palmitoyltransferase ZDHHC20; Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains (By similarity)."},{"id":"ENSMUSP00000045910","abundance":0.862,"rank":11590,"name":"Inpp5f","annotation":"Phosphatidylinositide phosphatase SAC2; Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (By similarity). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation [...] "},{"id":"ENSMUSP00000144962","abundance":0.862,"rank":11591,"name":"Klf15","annotation":"Krueppel-like factor 15; Transcriptional regulator that binds to the GA element of the CLCNKA promoter (By similarity). Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart. Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. Is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A, GATA4 and MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation (By similarity). Involved in podocyte differentiation."},{"id":"ENSMUSP00000018993","abundance":0.861,"rank":11592,"name":"Wwc1","annotation":"Protein KIBRA; Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with NF2 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. Acts as a transcriptional coactivator of ESR1 which plays an essential role in DYNLL1-mediated ESR1 transactivation. Regulates collagen-stimulated activation of the ERK/MAPK cascade. Modulates directional migrati [...] "},{"id":"ENSMUSP00000030886","abundance":0.861,"rank":11593,"name":"Miip","annotation":"Migration and invasion-inhibitory protein; Inhibits glioma cells invasion and down-regulates adhesion- and motility-associated genes such as NFKB2 and ICAM1. Exhibits opposing effects to IGFBP2 on cell invasion (By similarity)."},{"id":"ENSMUSP00000123102","abundance":0.861,"rank":11594,"name":"Zfp960","annotation":"Zinc finger protein 960."},{"id":"ENSMUSP00000106664","abundance":0.86,"rank":11595,"name":"Pop7","annotation":"Ribonuclease P protein subunit p20; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the histone-like Alba family."},{"id":"ENSMUSP00000068403","abundance":0.86,"rank":11596,"name":"Alg13","annotation":"Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13; [Isoform 1]: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities."},{"id":"ENSMUSP00000051368","abundance":0.86,"rank":11597,"name":"Ltb4r1","annotation":"Leukotriene B4 receptor 1; Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000041671","abundance":0.86,"rank":11598,"name":"Fam117b","annotation":"Protein FAM117B."},{"id":"ENSMUSP00000010421","abundance":0.86,"rank":11599,"name":"2610507B11Rik","annotation":"Protein KIAA0100; May be involved in membrane trafficking. Belongs to the SABRE family."},{"id":"ENSMUSP00000099758","abundance":0.86,"rank":11600,"name":"Flcn","annotation":"Folliculin; May be a tumor suppressor. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1; Belongs to the folliculin family."},{"id":"ENSMUSP00000000127","abundance":0.859,"rank":11601,"name":"Wnt3","annotation":"Proto-oncogene Wnt-3; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Required for normal gastrulation, formation of the primitive streak, and for the formation of the mesoderm during early embryogenesis. Required for normal formation of the apical ectodermal ridge and for normal embryonic limb development."},{"id":"ENSMUSP00000031650","abundance":0.859,"rank":11602,"name":"Cdx2","annotation":"Homeobox protein CDX-2; Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA; Belongs to the Caudal homeobox family."},{"id":"ENSMUSP00000063660","abundance":0.859,"rank":11603,"name":"Ffar4","annotation":"Free fatty acid receptor 4; Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega- 3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)- coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. Mediates the taste of fatty acids. Mediates FFA [...] "},{"id":"ENSMUSP00000100617","abundance":0.859,"rank":11604,"name":"Otud1","annotation":"OTU domain-containing protein 1; Deubiquitinating enzyme that specifically hydrolyzes 'Lys- 63'-linked polyubiquitin to monoubiquitin."},{"id":"ENSMUSP00000063380","abundance":0.859,"rank":11605,"name":"Kcnq3","annotation":"Potassium voltage-gated channel subfamily KQT member 3; Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability."},{"id":"ENSMUSP00000114909","abundance":0.859,"rank":11606,"name":"Efcab6","annotation":"EF-hand calcium-binding domain-containing protein 6; Negatively regulates the androgen receptor by recruiting histone deacetylase complex, and protein DJ-1 antagonizes this inhibition by abrogation of this complex."},{"id":"ENSMUSP00000108144","abundance":0.858,"rank":11607,"name":"Pla2r1","annotation":"Soluble secretory phospholipase A2 receptor; Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipases sPLA2-IB/PLA2G1B, sPLA2-X/PLA2G10 and, with lower affinity, sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2- IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascad [...] "},{"id":"ENSMUSP00000047015","abundance":0.858,"rank":11608,"name":"Churc1","annotation":"Protein Churchill; Transcriptional activator that mediates FGF signaling during neural development. Plays a role in the regulation of cell movement. Does not bind DNA by itself (By similarity); Belongs to the Churchill family."},{"id":"ENSMUSP00000054611","abundance":0.858,"rank":11609,"name":"Tmem251","annotation":"Transmembrane protein 251."},{"id":"ENSMUSP00000038662","abundance":0.858,"rank":11610,"name":"Ankrd13c","annotation":"Ankyrin repeat domain-containing protein 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER."},{"id":"ENSMUSP00000062320","abundance":0.858,"rank":11611,"name":"Gja4","annotation":"Gap junction alpha-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily."},{"id":"ENSMUSP00000062429","abundance":0.857,"rank":11612,"name":"Rasip1","annotation":"Ras-interacting protein 1; Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS-mediated trans [...] "},{"id":"ENSMUSP00000034742","abundance":0.857,"rank":11613,"name":"Ccnb2","annotation":"G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition."},{"id":"ENSMUSP00000092388","abundance":0.856,"rank":11614,"name":"Psg27","annotation":"Pregnancy-specific glycoprotein 27."},{"id":"ENSMUSP00000062413","abundance":0.856,"rank":11615,"name":"Sfswap","annotation":"Splicing factor, suppressor of white-apricot homolog; Plays a role as an alternative splicing regulator. Regulates its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10 (By similarity)."},{"id":"ENSMUSP00000014917","abundance":0.856,"rank":11616,"name":"Dll1","annotation":"Dll1-derived cell-associated form; Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner. Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signaling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intrace [...] "},{"id":"ENSMUSP00000030902","abundance":0.856,"rank":11617,"name":"Prdm16","annotation":"Histone-lysine N-methyltransferase PRDM16; Binds DNA and functions as a transcriptional regulator. Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with MECOM/PRDM3 that direct cytoplasmic H3K9me1 methylation. Functions  [...] "},{"id":"ENSMUSP00000049103","abundance":0.856,"rank":11618,"name":"Slc2a6","annotation":"Solute carrier family 2, facilitated glucose transporter member 6; Probable sugar transporter that acts as a regulator of glycolysis in macrophages. Does not transport glucose (By similarity)."},{"id":"ENSMUSP00000031778","abundance":0.856,"rank":11619,"name":"1700012A03Rik","annotation":"RIKEN cDNA 1700012A03 gene."},{"id":"ENSMUSP00000108755","abundance":0.856,"rank":11620,"name":"Mroh2a","annotation":"Maestro heat-like repeat-containing protein family member 2A."},{"id":"ENSMUSP00000052056","abundance":0.855,"rank":11621,"name":"Ankrd16","annotation":"Ankyrin repeat domain-containing protein 16; Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides."},{"id":"ENSMUSP00000025739","abundance":0.855,"rank":11622,"name":"Uhrf2","annotation":"E3 ubiquitin-protein ligase UHRF2; E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131 (By similarity). E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells."},{"id":"ENSMUSP00000052765","abundance":0.855,"rank":11623,"name":"1110012L19Rik","annotation":"Uncharacterized protein CXorf40 homolog."},{"id":"ENSMUSP00000039473","abundance":0.855,"rank":11624,"name":"Rcan2","annotation":"Calcipressin-2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development; Belongs to the RCAN family."},{"id":"ENSMUSP00000150701","abundance":0.855,"rank":11625,"name":"Cdkn2d","annotation":"Cyclin-dependent kinase 4 inhibitor D; Interacts strongly with CDK4 and CDK6 and inhibits them."},{"id":"ENSMUSP00000025234","abundance":0.855,"rank":11626,"name":"Epb41l4a","annotation":"Band 4.1-like protein 4A."},{"id":"ENSMUSP00000028881","abundance":0.854,"rank":11627,"name":"Il1b","annotation":"Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family."},{"id":"ENSMUSP00000039440","abundance":0.854,"rank":11628,"name":"Syne1","annotation":"Nesprin-1; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. May be involved in nucleus- centrosome attachment. During interkineti [...] "},{"id":"ENSMUSP00000002924","abundance":0.854,"rank":11629,"name":"Tmem39a","annotation":"Transmembrane protein 39A; Belongs to the TMEM39 family."},{"id":"ENSMUSP00000135597","abundance":0.854,"rank":11630,"name":"Pou5f2","annotation":"POU domain, class 5, transcription factor 2; Transcription factor that binds preferentially to the octamer motif (5'-ATGTTAAT-3'). May exert a regulatory function in meiotic events that are required for terminal differentiation of male germ cell (By similarity); Belongs to the POU transcription factor family. Class-5 subfamily."},{"id":"ENSMUSP00000097876","abundance":0.853,"rank":11631,"name":"Card9","annotation":"Caspase recruitment domain-containing protein 9; Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti- fungal immunity: acts by regulatin [...] "},{"id":"ENSMUSP00000023830","abundance":0.853,"rank":11632,"name":"Nus1","annotation":"Dehydrodolichyl diphosphate synthase complex subunit Nus1; With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stabilit [...] "},{"id":"ENSMUSP00000046658","abundance":0.853,"rank":11633,"name":"Actr5","annotation":"Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair (By similarity). Belongs to the actin family. ARP5 subfamily."},{"id":"ENSMUSP00000084573","abundance":0.853,"rank":11634,"name":"Capn6","annotation":"Calpain-6; Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues."},{"id":"ENSMUSP00000158891","abundance":0.853,"rank":11635,"name":"Fam161a","annotation":"Protein FAM161A; Involved in ciliogenesis."},{"id":"ENSMUSP00000105736","abundance":0.853,"rank":11636,"name":"Plcb4","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes."},{"id":"ENSMUSP00000093469","abundance":0.852,"rank":11637,"name":"Rnf17","annotation":"RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis."},{"id":"ENSMUSP00000078158","abundance":0.851,"rank":11638,"name":"Abcc5","annotation":"Multidrug resistance-associated protein 5; Acts as a multispecific organic anion pump which can transport nucleotide analogs; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily."},{"id":"ENSMUSP00000077995","abundance":0.851,"rank":11639,"name":"G6pc3","annotation":"Glucose-6-phosphatase 3; Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. May form with the glucose-6-phosphate transporter (SLC37A4/G6PT) a ubiquitously expressed complex responsible for glucose production through glycogenolysis and gluconeogenesis. Probably required for normal neutrophil function."},{"id":"ENSMUSP00000094036","abundance":0.851,"rank":11640,"name":"Tbc1d8b","annotation":"TBC1 domain family member 8B; Involved in vesicular recycling, probably as a RAB11B GTPase- activating protein."},{"id":"ENSMUSP00000049414","abundance":0.851,"rank":11641,"name":"Dusp8","annotation":"Dual specificity protein phosphatase 8; Has phosphatase activity with synthetic phosphatase substrates and negatively regulates mitogen-activated protein kinase activity, presumably by catalysing their dephosphorylation. Expected to display protein phosphatase activity toward phosphotyrosine, phosphoserine and phosphothreonine residues (Probable)."},{"id":"ENSMUSP00000091553","abundance":0.851,"rank":11642,"name":"Fam57a","annotation":"TLC domain-containing protein 3A."},{"id":"ENSMUSP00000034543","abundance":0.851,"rank":11643,"name":"Rpusd4","annotation":"Mitochondrial RNA pseudouridine synthase Rpusd4; Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. Acts on position 39 in mitochondrial tRNA(Phe). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt- rRNA, controls 16S mt-rRNA abundance and is required for intra- mitochondrial translation."},{"id":"ENSMUSP00000109734","abundance":0.851,"rank":11644,"name":"Otop1","annotation":"Proton channel OTOP1; Proton-selective channel that specifically transports protons into cells. Proton channel activity is only weakly- sensitive to voltage. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes. In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration. Probably acts by maintaining the pH appropriate for formation of otoconia. Regulates [...] "},{"id":"ENSMUSP00000019064","abundance":0.85,"rank":11645,"name":"Cxcl16","annotation":"C-X-C motif chemokine 16; Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo. Also acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis; Belongs to the intercrine alpha (chemokine CxC) family."},{"id":"ENSMUSP00000123924","abundance":0.849,"rank":11646,"name":"Selp","annotation":"P-selectin; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG."},{"id":"ENSMUSP00000023554","abundance":0.849,"rank":11647,"name":"Slc49a4","annotation":"Solute carrier family 49 member 4; Electrogenic metabolite transporter."},{"id":"ENSMUSP00000025908","abundance":0.849,"rank":11648,"name":"Kcnk4","annotation":"Potassium channel subfamily K member 4; Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the sensory perception of pain caused by pressure. Plays a role i [...] "},{"id":"ENSMUSP00000015509","abundance":0.849,"rank":11649,"name":"Mov10l1","annotation":"RNA helicase Mov10l1; [Isoform 1]: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragm [...] "},{"id":"ENSMUSP00000052777","abundance":0.849,"rank":11650,"name":"Pik3ap1","annotation":"Phosphoinositide 3-kinase adapter protein 1; Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3- kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll- like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival o [...] "},{"id":"ENSMUSP00000076418","abundance":0.849,"rank":11651,"name":"Polr3b","annotation":"DNA-directed RNA polymerase III subunit RPC2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef [...] "},{"id":"ENSMUSP00000109109","abundance":0.848,"rank":11652,"name":"Zfp318","annotation":"Zinc finger protein 318; [Isoform 2]: Acts as a transcriptional corepressor for AR- mediated transactivation function. May act as a transcriptional regulator during spermatogenesis and in particular, during meiotic division."},{"id":"ENSMUSP00000035079","abundance":0.848,"rank":11653,"name":"Mlh1","annotation":"DNA mismatch repair protein Mlh1; Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing t [...] "},{"id":"ENSMUSP00000038761","abundance":0.848,"rank":11654,"name":"Sik2","annotation":"Serine/threonine-protein kinase SIK2; Phosphorylates 'Ser-789' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily."},{"id":"ENSMUSP00000067445","abundance":0.847,"rank":11655,"name":"Stfa3","annotation":"Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family."},{"id":"ENSMUSP00000058810","abundance":0.847,"rank":11656,"name":"Olfr77","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000091502","abundance":0.847,"rank":11657,"name":"Myo19","annotation":"Unconventional myosin-XIX; Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane. Motor protein that moves towards the plus-end of actin filaments. Required for mitochondrial inheritance during mitosis (By similarity). May be involved in mitochondrial transport or positioning (By similarity)."},{"id":"ENSMUSP00000111475","abundance":0.847,"rank":11658,"name":"Ammecr1l","annotation":"AMMECR1-like protein."},{"id":"ENSMUSP00000066637","abundance":0.847,"rank":11659,"name":"Rnase9","annotation":"Inactive ribonuclease-like protein 9; Does not exhibit any ribonuclease activity; Belongs to the pancreatic ribonuclease family."},{"id":"ENSMUSP00000036082","abundance":0.847,"rank":11660,"name":"Nbas","annotation":"Neuroblastoma-amplified sequence."},{"id":"ENSMUSP00000047030","abundance":0.847,"rank":11661,"name":"Erv3","annotation":"Endogenous retroviral sequence 3."},{"id":"ENSMUSP00000038361","abundance":0.847,"rank":11662,"name":"Abhd2","annotation":"Monoacylglycerol lipase ABHD2; Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1- arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2A [...] "},{"id":"ENSMUSP00000099693","abundance":0.846,"rank":11663,"name":"Atxn7l2","annotation":"Ataxin 7-like 2."},{"id":"ENSMUSP00000092779","abundance":0.846,"rank":11664,"name":"Phf11d","annotation":"PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression."},{"id":"ENSMUSP00000060099","abundance":0.846,"rank":11665,"name":"Tacstd2","annotation":"Tumor-associated calcium signal transducer 2; May function as a growth factor receptor."},{"id":"ENSMUSP00000044836","abundance":0.846,"rank":11666,"name":"Tut4","annotation":"Terminal uridylyltransferase 4; Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (By s [...] "},{"id":"ENSMUSP00000124133","abundance":0.846,"rank":11667,"name":"Hipk2","annotation":"Homeodomain-interacting protein kinase 2; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect [...] "},{"id":"ENSMUSP00000034085","abundance":0.845,"rank":11668,"name":"Brd7","annotation":"Bromodomain-containing protein 7; Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down- regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby pro [...] "},{"id":"ENSMUSP00000058412","abundance":0.845,"rank":11669,"name":"Tmem82","annotation":"Transmembrane protein 82."},{"id":"ENSMUSP00000142175","abundance":0.845,"rank":11670,"name":"Cnga3","annotation":"Cyclic nucleotide-gated cation channel alpha-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and e [...] "},{"id":"ENSMUSP00000034280","abundance":0.845,"rank":11671,"name":"Zdhhc7","annotation":"Palmitoyltransferase ZDHHC7; Palmitoyltransferase with broad specificity. Palmitoylates JAM3 (By similarity). Palmitoylates SNAP25 and DLG4/PSD95. Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity)."},{"id":"ENSMUSP00000020911","abundance":0.844,"rank":11672,"name":"Sdc1","annotation":"Syndecan-1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP."},{"id":"ENSMUSP00000093816","abundance":0.844,"rank":11673,"name":"Ifit1bl2","annotation":"Interferon-induced protein with tetratricopeptide repeats 1B-like 2."},{"id":"ENSMUSP00000057106","abundance":0.843,"rank":11674,"name":"Olig3","annotation":"Oligodendrocyte transcription factor 3; May determine the distinct specification program of class A neurons in the dorsal part of the spinal cord and suppress specification of class B neurons."},{"id":"ENSMUSP00000055343","abundance":0.843,"rank":11675,"name":"Il17rc","annotation":"Interleukin-17 receptor C; Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (By similarity). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (By similarity)."},{"id":"ENSMUSP00000127178","abundance":0.843,"rank":11676,"name":"Zfp871","annotation":"Zinc finger protein 871."},{"id":"ENSMUSP00000051246","abundance":0.843,"rank":11677,"name":"Pxdc1","annotation":"PX domain-containing protein 1."},{"id":"ENSMUSP00000101104","abundance":0.843,"rank":11678,"name":"Cdh23","annotation":"Cadherin-23; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing."},{"id":"ENSMUSP00000069495","abundance":0.843,"rank":11679,"name":"Abcg5","annotation":"ATP-binding cassette sub-family G member 5; ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity."},{"id":"ENSMUSP00000155111","abundance":0.843,"rank":11680,"name":"Elfn2","annotation":"Protein phosphatase 1 regulatory subunit 29; Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes."},{"id":"ENSMUSP00000020365","abundance":0.842,"rank":11681,"name":"Pwwp3a","annotation":"PWWP domain-containing DNA repair factor 3A; Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity); Belongs to the PWWP3A family."},{"id":"ENSMUSP00000003870","abundance":0.842,"rank":11682,"name":"Mxi1","annotation":"Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX. Isoform Short, which lacks a segment, has a much stronger suppressive potential and associates with a SIN3 homologous protein."},{"id":"ENSMUSP00000028552","abundance":0.841,"rank":11683,"name":"Katnbl1","annotation":"KATNB1-like protein 1; Regulates microtubule-severing activity of KATNAL1 in a concentration-dependent manner in vitro."},{"id":"ENSMUSP00000148130","abundance":0.841,"rank":11684,"name":"Olfr588-ps1","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000062607","abundance":0.841,"rank":11685,"name":"Pla2g4f","annotation":"Cytosolic phospholipase A2 zeta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine."},{"id":"ENSMUSP00000052619","abundance":0.841,"rank":11686,"name":"Pard6b","annotation":"Partitioning defective 6 homolog beta; Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins; Belongs to the PAR6 family."},{"id":"ENSMUSP00000110281","abundance":0.841,"rank":11687,"name":"Boc","annotation":"Brother of CDO; Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells."},{"id":"ENSMUSP00000031539","abundance":0.84,"rank":11688,"name":"Snx8","annotation":"Sorting nexin-8; May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network (By similarity). Belongs to the sorting nexin family."},{"id":"ENSMUSP00000045598","abundance":0.84,"rank":11689,"name":"Asic4","annotation":"Acid-sensing ion channel 4; Probable cation channel with high affinity for sodium; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC4 subfamily."},{"id":"ENSMUSP00000133215","abundance":0.84,"rank":11690,"name":"Atg7","annotation":"Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] "},{"id":"ENSMUSP00000110593","abundance":0.84,"rank":11691,"name":"Dcc","annotation":"Netrin receptor DCC; Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene."},{"id":"ENSMUSP00000043902","abundance":0.84,"rank":11692,"name":"Lcn8","annotation":"Epididymal-specific lipocalin-8; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis."},{"id":"ENSMUSP00000037459","abundance":0.839,"rank":11693,"name":"Zfand1","annotation":"AN1-type zinc finger protein 1; Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress. Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome. This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during  [...] "},{"id":"ENSMUSP00000020071","abundance":0.839,"rank":11694,"name":"Sim1","annotation":"Single-minded homolog 1; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult."},{"id":"ENSMUSP00000029049","abundance":0.839,"rank":11695,"name":"Chmp4c","annotation":"Charged multivesicular body protein 4c; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential functio [...] "},{"id":"ENSMUSP00000145743","abundance":0.839,"rank":11696,"name":"Bcl7c","annotation":"B-cell CLL/lymphoma 7 protein family member C; May play an anti-apoptotic role. Belongs to the BCL7 family."},{"id":"ENSMUSP00000060331","abundance":0.839,"rank":11697,"name":"Swsap1","annotation":"ATPase SWSAP1; ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity (By similarity)."},{"id":"ENSMUSP00000103857","abundance":0.839,"rank":11698,"name":"Mms22l","annotation":"Protein MMS22-like; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA (By similarity)."},{"id":"ENSMUSP00000110447","abundance":0.838,"rank":11699,"name":"Tead3","annotation":"Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] "},{"id":"ENSMUSP00000079613","abundance":0.838,"rank":11700,"name":"Cdh3","annotation":"Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."},{"id":"ENSMUSP00000030676","abundance":0.838,"rank":11701,"name":"Grik3","annotation":"Glutamate receptor ionotropic, kainate 3; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA (By similarity); Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. G [...] "},{"id":"ENSMUSP00000082800","abundance":0.838,"rank":11702,"name":"Insyn1","annotation":"Inhibitory synaptic factor 1; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code."},{"id":"ENSMUSP00000120840","abundance":0.838,"rank":11703,"name":"Fbxo7","annotation":"F-box only protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity)."},{"id":"ENSMUSP00000097895","abundance":0.838,"rank":11704,"name":"Fut7","annotation":"Alpha-(1,3)-fucosyltransferase 7; Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates to the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization. In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and [...] "},{"id":"ENSMUSP00000021544","abundance":0.837,"rank":11705,"name":"Plek2","annotation":"Pleckstrin-2; May help orchestrate cytoskeletal arrangement. Contribute to lamellipodia formation. Overexpression of pleckstrin 2 causes large lamellipodia and peripheral ruffle formation."},{"id":"ENSMUSP00000150319","abundance":0.837,"rank":11706,"name":"Olfr1037","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000026410","abundance":0.837,"rank":11707,"name":"Dnajc14","annotation":"DnaJ homolog subfamily C member 14; Regulates the export of target proteins, such as DRD1, from the endoplasmic reticulum to the cell surface."},{"id":"ENSMUSP00000065764","abundance":0.836,"rank":11708,"name":"Slc30a5","annotation":"Zinc transporter 5; Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily."},{"id":"ENSMUSP00000041088","abundance":0.836,"rank":11709,"name":"Prss42","annotation":"Serine protease 42; Plays a role in spermatogenesis. Involved in germ cell survival during meiosis; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000021134","abundance":0.835,"rank":11710,"name":"Tsen54","annotation":"tRNA-splicing endonuclease subunit Sen54; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA bo [...] "},{"id":"ENSMUSP00000158133","abundance":0.834,"rank":11711,"name":"1810055G02Rik","annotation":"Uncharacterized protein C11orf24 homolog."},{"id":"ENSMUSP00000047690","abundance":0.834,"rank":11712,"name":"Slc6a20a","annotation":"Sodium- and chloride-dependent transporter XTRP3A; Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids."},{"id":"ENSMUSP00000095260","abundance":0.834,"rank":11713,"name":"Asxl3","annotation":"Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity)."},{"id":"ENSMUSP00000135860","abundance":0.834,"rank":11714,"name":"Vmn1r25","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000054125","abundance":0.834,"rank":11715,"name":"Fbxo43","annotation":"F-box only protein 43; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation."},{"id":"ENSMUSP00000099857","abundance":0.833,"rank":11716,"name":"Ebf1","annotation":"Transcription factor COE1; Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Belongs to the COE family."},{"id":"ENSMUSP00000040896","abundance":0.833,"rank":11717,"name":"Socs7","annotation":"Suppressor of cytokine signaling 7; Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of ta [...] "},{"id":"ENSMUSP00000106063","abundance":0.832,"rank":11718,"name":"Btn2a2","annotation":"Butyrophilin subfamily 2 member A2; Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion."},{"id":"ENSMUSP00000040505","abundance":0.832,"rank":11719,"name":"Hlx","annotation":"H2.0-like homeobox protein; Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis."},{"id":"ENSMUSP00000145491","abundance":0.832,"rank":11720,"name":"Tarm1","annotation":"T-cell-interacting, activating receptor on myeloid cells protein 1; May act as receptor. Negatively regulates TCR-mediated CD4(+) T cell proliferation and activation, possibly by binding an unknown ligand on the T cell surface. Enhances Toll-like receptor-mediated production of pro-inflammatory cytokines by macrophages and neutrophils."},{"id":"ENSMUSP00000110222","abundance":0.831,"rank":11721,"name":"Vma21","annotation":"Vacuolar ATPase assembly integral membrane protein Vma21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum; Belongs to the VMA21 family."},{"id":"ENSMUSP00000117687","abundance":0.831,"rank":11722,"name":"Fbxo30","annotation":"F-box only protein 30; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation."},{"id":"ENSMUSP00000123426","abundance":0.831,"rank":11723,"name":"Ermap","annotation":"Erythroid membrane-associated protein; Possible role as a cell-adhesion or receptor molecule of erythroid cells; Belongs to the immunoglobulin superfamily. BTN/MOG family."},{"id":"ENSMUSP00000031040","abundance":0.831,"rank":11724,"name":"Cwh43","annotation":"PGAP2-interacting protein; Involved in lipid remodeling during GPI-anchor maturation. Belongs to the PGAP2IP family."},{"id":"ENSMUSP00000093431","abundance":0.831,"rank":11725,"name":"Nat8f3","annotation":"N-acetyltransferase family 8 member 3."},{"id":"ENSMUSP00000056287","abundance":0.83,"rank":11726,"name":"Sprr3","annotation":"Small proline-rich protein 3; Cross-linked envelope protein of keratinocytes; Belongs to the cornifin (SPRR) family."},{"id":"ENSMUSP00000019913","abundance":0.83,"rank":11727,"name":"Frk","annotation":"Tyrosine-protein kinase FRK; Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor (By similarity)."},{"id":"ENSMUSP00000024762","abundance":0.83,"rank":11728,"name":"Rsph9","annotation":"Radial spoke head protein 9 homolog; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk, which is attached to a subfiber of the outer doublet microtubule, and a bulbous head, which is attached to the stalk and appears to interact with the projections from the central pair of microtubules."},{"id":"ENSMUSP00000020185","abundance":0.83,"rank":11729,"name":"Il20ra","annotation":"Interleukin-20 receptor subunit alpha; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26 (By similarity)."},{"id":"ENSMUSP00000060103","abundance":0.83,"rank":11730,"name":"Trim26","annotation":"Tripartite motif-containing protein 26; E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000107806","abundance":0.83,"rank":11731,"name":"Tceanc","annotation":"Transcription elongation factor A N-terminal and central domain-containing protein."},{"id":"ENSMUSP00000126560","abundance":0.83,"rank":11732,"name":"Lrrcc1","annotation":"Leucine-rich repeat and coiled-coil domain-containing protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis (By similarity)."},{"id":"ENSMUSP00000051250","abundance":0.829,"rank":11733,"name":"Arxes2","annotation":"Adipocyte-related X-chromosome expressed sequence 1; Plays a role in adipogenesis; Belongs to the SPCS3 family."},{"id":"ENSMUSP00000062660","abundance":0.829,"rank":11734,"name":"Arxes1","annotation":"Adipocyte-related X-chromosome expressed sequence 1."},{"id":"ENSMUSP00000101648","abundance":0.829,"rank":11735,"name":"Phrf1","annotation":"PHD and RING finger domain-containing protein 1."},{"id":"ENSMUSP00000032422","abundance":0.829,"rank":11736,"name":"Creld1","annotation":"Protein disulfide isomerase Creld1; Protein disulfide isomerase (By similarity). Promotes the localization of acetylcholine receptors (AChRs) to the plasma membrane ; Belongs to the CRELD family."},{"id":"ENSMUSP00000023741","abundance":0.829,"rank":11737,"name":"Kmt2d","annotation":"Histone-lysine N-methyltransferase 2D; Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription."},{"id":"ENSMUSP00000022232","abundance":0.829,"rank":11738,"name":"Nt5el","annotation":"5' nucleotidase, ecto-like; Belongs to the 5'-nucleotidase family."},{"id":"ENSMUSP00000022451","abundance":0.829,"rank":11739,"name":"Capn7","annotation":"Calpain-7; Calcium-regulated non-lysosomal thiol-protease."},{"id":"ENSMUSP00000027404","abundance":0.829,"rank":11740,"name":"Ptprn","annotation":"Receptor-type tyrosine-protein phosphatase-like N; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary horm [...] "},{"id":"ENSMUSP00000025924","abundance":0.828,"rank":11741,"name":"Spindoc","annotation":"Spindlin interactor and repressor of chromatin-binding protein; Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability. Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway. Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (By similarity)."},{"id":"ENSMUSP00000100070","abundance":0.828,"rank":11742,"name":"Shroom4","annotation":"Protein Shroom4; Probable regulator of cytoskeletal architecture that plays an important role in development. May regulate cellular and cytoskeletal architecture by modulating the spatial distribution of myosin II. Belongs to the shroom family."},{"id":"ENSMUSP00000152151","abundance":0.828,"rank":11743,"name":"Nlrp4f","annotation":"NACHT, LRR and PYD domains-containing protein 4F; May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors."},{"id":"ENSMUSP00000108098","abundance":0.828,"rank":11744,"name":"Parp3","annotation":"Protein mono-ADP-ribosyltransferase PARP3; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP- ribosylation of glutamate, aspartate or lysine residues on target proteins (By similarity). In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromat [...] "},{"id":"ENSMUSP00000038484","abundance":0.828,"rank":11745,"name":"Ttc13","annotation":"Tetratricopeptide repeat domain 13."},{"id":"ENSMUSP00000001562","abundance":0.827,"rank":11746,"name":"Tulp3","annotation":"Tubby-related protein 3; Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT- A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis; Belongs to the TUB family."},{"id":"ENSMUSP00000025861","abundance":0.827,"rank":11747,"name":"Ovol1","annotation":"Putative transcription factor Ovo-like 1; Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system."},{"id":"ENSMUSP00000036484","abundance":0.827,"rank":11748,"name":"Spag4","annotation":"Sperm-associated antigen 4 protein; Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODF [...] "},{"id":"ENSMUSP00000056084","abundance":0.827,"rank":11749,"name":"Gm11437","annotation":"Uncharacterized protein C17orf78 homolog."},{"id":"ENSMUSP00000067898","abundance":0.827,"rank":11750,"name":"Wls","annotation":"Protein wntless homolog; Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins. Plays also an important role in establishment of the anterior-posterior body axis formation during development."},{"id":"ENSMUSP00000025396","abundance":0.827,"rank":11751,"name":"Rax","annotation":"Retinal homeobox protein Rx; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. Binds to the photoreceptor conserved element-I (PCE- 1/Ret 1) in the photoreceptor cell-specific arrestin promoter (By similarity); Belongs to the paired homeobox family. Bicoid subfamily."},{"id":"ENSMUSP00000054219","abundance":0.826,"rank":11752,"name":"Cldn2","annotation":"Claudin-2; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family."},{"id":"ENSMUSP00000129447","abundance":0.826,"rank":11753,"name":"Rbm20","annotation":"RNA-binding protein 20; RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin)."},{"id":"ENSMUSP00000043127","abundance":0.826,"rank":11754,"name":"Cmtm2b","annotation":"CKLF-like MARVEL transmembrane domain-containing protein 2B; Belongs to the chemokine-like factor family."},{"id":"ENSMUSP00000038166","abundance":0.825,"rank":11755,"name":"Poglut1","annotation":"Protein O-glucosyltransferase 1; Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C- X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2. Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity). Notch glucosylation does not affect Notch ligand binding (By similarity). Required during early development to promote gas [...] "},{"id":"ENSMUSP00000000186","abundance":0.825,"rank":11756,"name":"Fgf23","annotation":"Fibroblast growth factor 23; Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Upregulates EGR1 expression in the presence of KL; Belongs to the heparin-binding growth factors family."},{"id":"ENSMUSP00000031868","abundance":0.825,"rank":11757,"name":"Slc13a4","annotation":"Solute carrier family 13 (sodium/sulfate symporters), member 4."},{"id":"ENSMUSP00000050999","abundance":0.825,"rank":11758,"name":"Slc26a11","annotation":"Sodium-independent sulfate anion transporter; Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC)."},{"id":"ENSMUSP00000041909","abundance":0.824,"rank":11759,"name":"Neil3","annotation":"Endonuclease 8-like 3; DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and G [...] "},{"id":"ENSMUSP00000107238","abundance":0.824,"rank":11760,"name":"Klhl20","annotation":"Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting inte [...] "},{"id":"ENSMUSP00000049541","abundance":0.824,"rank":11761,"name":"Ccdc74a","annotation":"Coiled-coil domain-containing 74A."},{"id":"ENSMUSP00000066448","abundance":0.824,"rank":11762,"name":"Mllt11","annotation":"Protein AF1q; Cofactor for the transcription factor TCF7. Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T-cell fate; Belongs to the MLLT11 family."},{"id":"ENSMUSP00000049938","abundance":0.824,"rank":11763,"name":"Olfr624","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000092794","abundance":0.824,"rank":11764,"name":"Atp2c2","annotation":"Calcium-transporting ATPase type 2C member 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium."},{"id":"ENSMUSP00000148886","abundance":0.824,"rank":11765,"name":"Olfr1313","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000071896","abundance":0.824,"rank":11766,"name":"Sh3rf2","annotation":"E3 ubiquitin-protein ligase SH3RF2; Has E3 ubiquitin-protein ligase activity. Acts as an anti- apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro- apoptotic JNK activation. Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation. Inhibits PPP1CA phosphatase activity (By similarity)."},{"id":"ENSMUSP00000099513","abundance":0.823,"rank":11767,"name":"Trpm7","annotation":"Transient receptor potential cation channel subfamily M member 7; Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A [...] "},{"id":"ENSMUSP00000150928","abundance":0.823,"rank":11768,"name":"Olfr669","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000022585","abundance":0.823,"rank":11769,"name":"Gpalpp1","annotation":"GPALPP motifs-containing protein 1."},{"id":"ENSMUSP00000037239","abundance":0.823,"rank":11770,"name":"B4galnt2","annotation":"Beta-1,4 N-acetylgalactosaminyltransferase 2; Responsible for synthesis of murine T-lymphocyte CT antigen. Can transfer N-acetylgalactosamine moiety from UDP-GalNAc to the low molecular weight acceptor 3'-sialyl-N-acetyllactosamine, to form a non- reducing terminal tetrasaccharide Sda blood group structure."},{"id":"ENSMUSP00000052644","abundance":0.823,"rank":11771,"name":"Tmem67","annotation":"Meckelin; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc)."},{"id":"ENSMUSP00000097656","abundance":0.823,"rank":11772,"name":"Zbtb2","annotation":"Zinc finger and BTB domain-containing 2."},{"id":"ENSMUSP00000045744","abundance":0.822,"rank":11773,"name":"Batf2","annotation":"Basic leucine zipper transcriptional factor ATF-like 2; AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types. Possibly acts by interfering with AP-1 binding to CCN1 promoter (By similarity). Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts [...] "},{"id":"ENSMUSP00000032283","abundance":0.822,"rank":11774,"name":"Ccdc77","annotation":"Coiled-coil domain-containing protein 77."},{"id":"ENSMUSP00000070168","abundance":0.822,"rank":11775,"name":"Gan","annotation":"Gigaxonin; Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival."},{"id":"ENSMUSP00000097258","abundance":0.821,"rank":11776,"name":"Gm7075","annotation":"Predicted gene 7075."},{"id":"ENSMUSP00000022038","abundance":0.821,"rank":11777,"name":"Naa35","annotation":"N-alpha-acetyltransferase 35, NatC auxiliary subunit; Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues. Involved in regulation of apoptosis and proliferation of smooth muscle cells."},{"id":"ENSMUSP00000116934","abundance":0.821,"rank":11778,"name":"Trpc2","annotation":"Transient receptor potential cation channel, subfamily C, member 2."},{"id":"ENSMUSP00000090510","abundance":0.821,"rank":11779,"name":"Synrg","annotation":"Synergin gamma; May play a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN). May act by linking the adapter protein complex AP-1 to other proteins (By similarity)."},{"id":"ENSMUSP00000047914","abundance":0.821,"rank":11780,"name":"Igsf23","annotation":"Immunoglobulin superfamily, member 23."},{"id":"ENSMUSP00000105949","abundance":0.821,"rank":11781,"name":"Zc3h6","annotation":"Zinc finger CCCH domain-containing protein 6."},{"id":"ENSMUSP00000027736","abundance":0.821,"rank":11782,"name":"Zc3h11a","annotation":"Zinc finger CCCH domain-containing protein 11A; Involved in nuclear mRNA export; probably mediated by association with the TREX complex."},{"id":"ENSMUSP00000141255","abundance":0.821,"rank":11783,"name":"Zc3h11a-2","annotation":"Zinc finger CCCH type containing 11A."},{"id":"ENSMUSP00000020884","abundance":0.821,"rank":11784,"name":"Atp6v1c2","annotation":"V-type proton ATPase subunit C 2; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells."},{"id":"ENSMUSP00000035549","abundance":0.82,"rank":11785,"name":"Pnmt","annotation":"Phenylethanolamine N-methyltransferase; Converts noradrenaline to adrenaline; Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family."},{"id":"ENSMUSP00000049228","abundance":0.82,"rank":11786,"name":"Cftr","annotation":"Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. M [...] "},{"id":"ENSMUSP00000058157","abundance":0.82,"rank":11787,"name":"Zbtb8b","annotation":"Zinc finger and BTB domain-containing protein 8B; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000125274","abundance":0.82,"rank":11788,"name":"Nxph1","annotation":"Neurexophilin-1; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins; Belongs to the neurexophilin family."},{"id":"ENSMUSP00000090613","abundance":0.82,"rank":11789,"name":"Camkk1","annotation":"Calcium/calmodulin-dependent protein kinase kinase 1; Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2- antagonist of cell death."},{"id":"ENSMUSP00000023694","abundance":0.819,"rank":11790,"name":"Cfap298","annotation":"Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity."},{"id":"ENSMUSP00000024338","abundance":0.819,"rank":11791,"name":"C1qtnf12","annotation":"Adipolin fC1QTNF12; Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue. [Adipolin gC1QTNF12]: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes."},{"id":"ENSMUSP00000125745","abundance":0.819,"rank":11792,"name":"Rnf123","annotation":"E3 ubiquitin-protein ligase RNF123; Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome- mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS."},{"id":"ENSMUSP00000078383","abundance":0.819,"rank":11793,"name":"Cep89","annotation":"Centrosomal protein of 89 kDa; Required for ciliogenesis. Also plays a role in mitochondrial metabolism where it may modulate complex IV activity (By similarity)."},{"id":"ENSMUSP00000112838","abundance":0.818,"rank":11794,"name":"Scn5a","annotation":"Sodium channel protein type 5 subunit alpha; This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels (By similarity). Belongs to  [...] "},{"id":"ENSMUSP00000108169","abundance":0.818,"rank":11795,"name":"Baz2b","annotation":"Bromodomain adjacent to zinc finger domain, 2B."},{"id":"ENSMUSP00000034869","abundance":0.817,"rank":11796,"name":"Isl2","annotation":"Insulin gene enhancer protein ISL-2; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways."},{"id":"ENSMUSP00000137381","abundance":0.817,"rank":11797,"name":"Zfp518b","annotation":"Zinc finger protein 518B; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000093789","abundance":0.817,"rank":11798,"name":"Ccdc136","annotation":"Coiled-coil domain-containing protein 136; May play a role in acrosome formation in spermatogenesis and in fertilization."},{"id":"ENSMUSP00000111247","abundance":0.817,"rank":11799,"name":"Ssxb9","annotation":"Synovial sarcoma, X member B9."},{"id":"ENSMUSP00000096421","abundance":0.817,"rank":11800,"name":"Zfp606","annotation":"Zinc finger protein 606."},{"id":"ENSMUSP00000025914","abundance":0.816,"rank":11801,"name":"Vegfb","annotation":"Vascular endothelial growth factor B; Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis. VEGF-B seems to be required for normal heart function in adult but is not required for proper development of the cardiovascular system either during development or for angiogenesis in adults."},{"id":"ENSMUSP00000072895","abundance":0.816,"rank":11802,"name":"Nlrp9b","annotation":"NACHT, LRR and PYD domains-containing protein 9B; As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell [...] "},{"id":"ENSMUSP00000107232","abundance":0.815,"rank":11803,"name":"Tnks1bp1","annotation":"182 kDa tankyrase-1-binding protein."},{"id":"ENSMUSP00000101312","abundance":0.815,"rank":11804,"name":"Tmem201","annotation":"Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. May recruit Ran GTPase to the nuclear periphery (By similarity). [Isoform 3]: Proposed to be involved in actin-dependent nuclear movement; via SUN2 associates with transmembrane actin- associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow."},{"id":"ENSMUSP00000149361","abundance":0.815,"rank":11805,"name":"Olfr525","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000105592","abundance":0.815,"rank":11806,"name":"Zfp707","annotation":"Zinc finger protein 707."},{"id":"ENSMUSP00000059883","abundance":0.814,"rank":11807,"name":"Cdc42ep2","annotation":"Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner (By similarity). Belongs to the BORG/CEP family."},{"id":"ENSMUSP00000088051","abundance":0.814,"rank":11808,"name":"Mybphl","annotation":"Myosin-binding protein H-like; Belongs to the immunoglobulin superfamily. MyBP family."},{"id":"ENSMUSP00000148495","abundance":0.813,"rank":11809,"name":"Iqcm","annotation":"IQ motif-containing M."},{"id":"ENSMUSP00000059637","abundance":0.813,"rank":11810,"name":"Nlrc4","annotation":"NLR family CARD domain-containing protein 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. It senses pathogenic proteins of the type III secretion system (T3SS) and type IV secretion system (T4SS) such as flagellin and PrgJ-like rod proteins via the Naip proteins (Naip1, Naip2 or Naip [...] "},{"id":"ENSMUSP00000084590","abundance":0.813,"rank":11811,"name":"Gm16223","annotation":"Predicted gene 16223."},{"id":"ENSMUSP00000137245","abundance":0.813,"rank":11812,"name":"Gm13275","annotation":"Predicted gene 13275."},{"id":"ENSMUSP00000092585","abundance":0.813,"rank":11813,"name":"Gm13288","annotation":"Predicted gene 13277."},{"id":"ENSMUSP00000100775","abundance":0.813,"rank":11814,"name":"Ifnz","annotation":"Interferon zeta."},{"id":"ENSMUSP00000140435","abundance":0.813,"rank":11815,"name":"Gm13276","annotation":"Predicted gene 13276."},{"id":"ENSMUSP00000136624","abundance":0.813,"rank":11816,"name":"Gm13277","annotation":"Predicted gene 13277."},{"id":"ENSMUSP00000136603","abundance":0.813,"rank":11817,"name":"Gm13290","annotation":"Predicted gene 13290."},{"id":"ENSMUSP00000136472","abundance":0.813,"rank":11818,"name":"Gm13279","annotation":"Predicted gene 13279."},{"id":"ENSMUSP00000137618","abundance":0.813,"rank":11819,"name":"Gm13278","annotation":"Predicted gene 13278."},{"id":"ENSMUSP00000136234","abundance":0.813,"rank":11820,"name":"Gm13287","annotation":"Predicted gene 13287."},{"id":"ENSMUSP00000135918","abundance":0.813,"rank":11821,"name":"Gm13272","annotation":"Predicted gene 13272."},{"id":"ENSMUSP00000137222","abundance":0.813,"rank":11822,"name":"Gm13285","annotation":"Predicted gene 13285."},{"id":"ENSMUSP00000135952","abundance":0.813,"rank":11823,"name":"Gm13289","annotation":"Predicted gene 13289."},{"id":"ENSMUSP00000053553","abundance":0.813,"rank":11824,"name":"Plcxd3","annotation":"PI-PLC X domain-containing protein 3."},{"id":"ENSMUSP00000150201","abundance":0.813,"rank":11825,"name":"Olfr1013","annotation":"Olfactory receptor 1013; Odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000063723","abundance":0.812,"rank":11826,"name":"Gm9925","annotation":"Predicted gene 9925."},{"id":"ENSMUSP00000142378","abundance":0.812,"rank":11827,"name":"Pfkfb4","annotation":"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4; Synthesis and degradation of fructose 2,6-bisphosphate. In the C-terminal section; belongs to the phosphoglycerate mutase family."},{"id":"ENSMUSP00000144011","abundance":0.812,"rank":11828,"name":"Hyal5","annotation":"Hyaluronidase-5; Catalyzes the hydrolysis of hyaluronan into smaller oligosaccharide fragments. Does not appear to be essential for fertilization."},{"id":"ENSMUSP00000023330","abundance":0.812,"rank":11829,"name":"Morc1","annotation":"MORC family CW-type zinc finger protein 1; Required for spermatogenesis."},{"id":"ENSMUSP00000086779","abundance":0.812,"rank":11830,"name":"Senp7","annotation":"Sentrin-specific protease 7; Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms; Belongs to the peptidase C48 family."},{"id":"ENSMUSP00000080215","abundance":0.812,"rank":11831,"name":"Pop5","annotation":"Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences. Belongs to the eukaryotic/archaeal RNase P protein component 2 family."},{"id":"ENSMUSP00000119083","abundance":0.811,"rank":11832,"name":"Pqlc1","annotation":"Solute carrier family 66 member 2."},{"id":"ENSMUSP00000157172","abundance":0.811,"rank":11833,"name":"Zfp598","annotation":"E3 ubiquitin-protein ligase ZNF598; E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide. Also acts as a component of the 4EHP-GYF2 complex, a multipr [...] "},{"id":"ENSMUSP00000010673","abundance":0.81,"rank":11834,"name":"Gm266","annotation":"Gene model 266, (NCBI)."},{"id":"ENSMUSP00000075609","abundance":0.81,"rank":11835,"name":"Itgb1bp1","annotation":"Integrin beta-1-binding protein 1; Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling [...] "},{"id":"ENSMUSP00000105574","abundance":0.81,"rank":11836,"name":"Hormad2","annotation":"HORMA domain-containing protein 2; Essential for synapsis surveillance during meiotic prophase via the recruitment of ATR activity. Plays a key role in the male mid- pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. Required for the DNA double-strand break- independent, BRCA1-dependent activation of ATR on the sex chromosomes that is essential for norm [...] "},{"id":"ENSMUSP00000063843","abundance":0.81,"rank":11837,"name":"Kansl1l","annotation":"KAT8 regulatory NSL complex subunit 1-like protein."},{"id":"ENSMUSP00000119745","abundance":0.809,"rank":11838,"name":"Mpnd","annotation":"MPN domain-containing protein; Probable protease (By similarity). Acts as a sensor of N(6)- methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its degradation (By similarity)."},{"id":"ENSMUSP00000043461","abundance":0.809,"rank":11839,"name":"1700013G24Rik","annotation":"RIKEN cDNA 1700013G24 gene."},{"id":"ENSMUSP00000050531","abundance":0.809,"rank":11840,"name":"Fam167b","annotation":"Protein FAM167B; Belongs to the FAM167 (SEC) family."},{"id":"ENSMUSP00000060194","abundance":0.809,"rank":11841,"name":"Fam131a","annotation":"Protein FAM131A; Belongs to the FAM131 family."},{"id":"ENSMUSP00000082588","abundance":0.809,"rank":11842,"name":"Klk8","annotation":"Kallikrein-8; Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte [...] "},{"id":"ENSMUSP00000028842","abundance":0.808,"rank":11843,"name":"Usp50","annotation":"Putative ubiquitin carboxyl-terminal hydrolase 50; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity). Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000064226","abundance":0.808,"rank":11844,"name":"Zfp277","annotation":"Zinc finger protein 277."},{"id":"ENSMUSP00000137903","abundance":0.807,"rank":11845,"name":"Zfp273","annotation":"Regulator of sex-limitation candidate 1."},{"id":"ENSMUSP00000117531","abundance":0.807,"rank":11846,"name":"Lsm11","annotation":"U7 snRNA-associated Sm-like protein LSm11; Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing. Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed. Required for cell cycle progression from G1 to S phases. Binds specifically to the Sm-binding site of U7 snRNA."},{"id":"ENSMUSP00000041578","abundance":0.807,"rank":11847,"name":"Rspo4","annotation":"R-spondin-4; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway."},{"id":"ENSMUSP00000124668","abundance":0.807,"rank":11848,"name":"Il21","annotation":"Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation; Belongs to the IL-1 [...] "},{"id":"ENSMUSP00000064060","abundance":0.807,"rank":11849,"name":"Tcaf3","annotation":"TRPM8 channel-associated factor 3; May play a role in the regulation of the cation channel TRPM8 activity."},{"id":"ENSMUSP00000048267","abundance":0.807,"rank":11850,"name":"Rassf4","annotation":"Ras association domain-containing protein 4; Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest."},{"id":"ENSMUSP00000091897","abundance":0.806,"rank":11851,"name":"Peg12","annotation":"Paternally-expressed 12."},{"id":"ENSMUSP00000076722","abundance":0.806,"rank":11852,"name":"Tmem236","annotation":"Transmembrane protein 236."},{"id":"ENSMUSP00000033975","abundance":0.805,"rank":11853,"name":"Ddhd2","annotation":"Phospholipase DDHD2; Phospholipase that hydrolyzes preferentially phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid, and phosphatidylethanolamine. Specifically binds to phosphatidylinositol 3- phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P), phosphatidylinositol 5-phosphate (PI(5)P) and possibly phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2). May be involved in the maintenance of the endoplasmic reticulum and/or Golgi structures. May regulate the transport between Golgi apparatus and plasma membrane (By similarity)."},{"id":"ENSMUSP00000031727","abundance":0.805,"rank":11854,"name":"Gigyf1","annotation":"GRB10-interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1."},{"id":"ENSMUSP00000042294","abundance":0.805,"rank":11855,"name":"Pcnx2","annotation":"Pecanex-like protein 2; May play a role in tumorigenesis."},{"id":"ENSMUSP00000088089","abundance":0.805,"rank":11856,"name":"Cttnbp2","annotation":"Cortactin-binding protein 2; Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, and thus controls dendritic spinogenesis and dendritic spine maintenance."},{"id":"ENSMUSP00000081664","abundance":0.805,"rank":11857,"name":"Cacng3","annotation":"Voltage-dependent calcium channel gamma-3 subunit; Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit- specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity)."},{"id":"ENSMUSP00000014499","abundance":0.805,"rank":11858,"name":"Anapc1","annotation":"Anaphase-promoting complex subunit 1; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity); Belongs to the APC1 family."},{"id":"ENSMUSP00000151049","abundance":0.804,"rank":11859,"name":"Olfr689","annotation":"Olfactory receptor MOR40-3."},{"id":"ENSMUSP00000041220","abundance":0.804,"rank":11860,"name":"Jmjd7","annotation":"Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7; Bifunctional enzyme that acts both as an endopeptidase and 2- oxoglutarate-dependent monoxygenase  (By similarity). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Additionally, m [...] "},{"id":"ENSMUSP00000074862","abundance":0.804,"rank":11861,"name":"Szt2","annotation":"KICSTOR complex protein SZT2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids (By similarity). In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation o [...] "},{"id":"ENSMUSP00000052109","abundance":0.804,"rank":11862,"name":"Mis18bp1","annotation":"Mis18-binding protein 1; Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis."},{"id":"ENSMUSP00000066721","abundance":0.804,"rank":11863,"name":"Gm11541","annotation":"Predicted gene, OTTMUSG00000002038."},{"id":"ENSMUSP00000014389","abundance":0.804,"rank":11864,"name":"Pigl","annotation":"N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; Involved in the second step of GPI biosynthesis. De-N- acetylation of N-acetylglucosaminyl-phosphatidylinositol (By similarity); Belongs to the PIGL family."},{"id":"ENSMUSP00000038591","abundance":0.804,"rank":11865,"name":"Socs5","annotation":"Suppressor of cytokine signaling 5; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T- helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes diff [...] "},{"id":"ENSMUSP00000096177","abundance":0.804,"rank":11866,"name":"Ccdc130","annotation":"Coiled-coil domain-containing protein 130."},{"id":"ENSMUSP00000030628","abundance":0.803,"rank":11867,"name":"Maco1","annotation":"Macoilin; Plays a role in the regulation of neuronal activity. Belongs to the macoilin family."},{"id":"ENSMUSP00000044730","abundance":0.803,"rank":11868,"name":"P2ry13","annotation":"P2Y purinoceptor 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system (By similarity)."},{"id":"ENSMUSP00000052805","abundance":0.803,"rank":11869,"name":"Klri2","annotation":"Killer cell lectin-like receptor subfamily I member 2; Lectin-like receptor for natural killer (NK) cells. Heterodimer formation with KLRE1 mediates NK cell cytolytic activity."},{"id":"ENSMUSP00000030460","abundance":0.803,"rank":11870,"name":"Gpbp1l1","annotation":"Vasculin-like protein 1; Possible transcription factor; Belongs to the vasculin family."},{"id":"ENSMUSP00000049864","abundance":0.802,"rank":11871,"name":"Ccdc54","annotation":"Coiled-coil domain-containing protein 54."},{"id":"ENSMUSP00000124938","abundance":0.802,"rank":11872,"name":"Kcnc1","annotation":"Potassium voltage-gated channel subfamily C member 1; Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action  [...] "},{"id":"ENSMUSP00000140218","abundance":0.802,"rank":11873,"name":"Gm20890","annotation":"Predicted gene, 20890."},{"id":"ENSMUSP00000140532","abundance":0.802,"rank":11874,"name":"Gm21488","annotation":"Predicted gene, 21488."},{"id":"ENSMUSP00000144620","abundance":0.802,"rank":11875,"name":"Mageb2","annotation":"Melanoma antigen, family B, 2."},{"id":"ENSMUSP00000078966","abundance":0.802,"rank":11876,"name":"Egln2","annotation":"Egl nine homolog 2; Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is  [...] "},{"id":"ENSMUSP00000057378","abundance":0.801,"rank":11877,"name":"Pudp","annotation":"Pseudouridine-5'-phosphatase; Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine."},{"id":"ENSMUSP00000064611","abundance":0.801,"rank":11878,"name":"Zfp180","annotation":"Zinc finger protein 180."},{"id":"ENSMUSP00000065160","abundance":0.801,"rank":11879,"name":"Kif1bp","annotation":"KIF-binding protein; Required for neuronal development and differentiation. Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development."},{"id":"ENSMUSP00000083538","abundance":0.8,"rank":11880,"name":"Milr1","annotation":"Allergin-1; Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction."},{"id":"ENSMUSP00000031709","abundance":0.8,"rank":11881,"name":"Fezf1","annotation":"Fez family zinc finger protein 1; Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000050127","abundance":0.8,"rank":11882,"name":"Aqp9","annotation":"Aquaporin-9; Forms a water channel with a broad specificity. Also permeable glycerol and urea. Mediates passage of a wide variety of small, non-charged solutes including carbamides, polyols, purines, and pyrimidines."},{"id":"ENSMUSP00000044578","abundance":0.8,"rank":11883,"name":"Arrdc4","annotation":"Arrestin domain-containing protein 4; Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (By similarity). Through an ubiquitination-dependent mechanism plays also a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake (By similarity)."},{"id":"ENSMUSP00000027128","abundance":0.799,"rank":11884,"name":"Ccdc150","annotation":"Coiled-coil domain-containing protein 150."},{"id":"ENSMUSP00000134062","abundance":0.799,"rank":11885,"name":"Iffo2","annotation":"Intermediate filament family orphan 2; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000134177","abundance":0.799,"rank":11886,"name":"Ak9","annotation":"Adenylate kinase 9."},{"id":"ENSMUSP00000105915","abundance":0.799,"rank":11887,"name":"Ebf4","annotation":"Transcription factor COE4; Seems to weakly activate transcription. Binds an Olf-1 consensus site in vitro; Belongs to the COE family."},{"id":"ENSMUSP00000101141","abundance":0.799,"rank":11888,"name":"Foxo3","annotation":"Forkhead box protein O3; Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins. Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress [...] "},{"id":"ENSMUSP00000034859","abundance":0.799,"rank":11889,"name":"Fbxo22","annotation":"F-box only protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome- dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function."},{"id":"ENSMUSP00000072687","abundance":0.798,"rank":11890,"name":"Foxb2","annotation":"Forkhead box protein B2; Transcription factor."},{"id":"ENSMUSP00000158945","abundance":0.798,"rank":11891,"name":"Arhgap39","annotation":"Rho GTPase-activating protein 39."},{"id":"ENSMUSP00000025956","abundance":0.798,"rank":11892,"name":"Pde6c","annotation":"Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. Belongs to the cyclic nucleotide phosphodiesterase family."},{"id":"ENSMUSP00000095602","abundance":0.798,"rank":11893,"name":"Focad","annotation":"Focadhesin; Potential tumor suppressor in gliomas."},{"id":"ENSMUSP00000076624","abundance":0.798,"rank":11894,"name":"Bloc1s3","annotation":"Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. Belongs to th [...] "},{"id":"ENSMUSP00000030047","abundance":0.798,"rank":11895,"name":"Tnfsf8","annotation":"Tumor necrosis factor ligand superfamily member 8; Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells."},{"id":"ENSMUSP00000106247","abundance":0.798,"rank":11896,"name":"Cplane1","annotation":"Ciliogenesis and planar polarity effector 1; Involved in ciliogenesis. Involved in the establishment of cell polarity required for directional cell migration. Proposed to act in association with the CPLANE (ciliogenesis and planar polarity effectors) complex. Involved in recruitment of peripheral IFT-A proteins to basal bodies."},{"id":"ENSMUSP00000028794","abundance":0.797,"rank":11897,"name":"Siglec1","annotation":"Sialoadhesin; Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells (By similarity). Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hematopoiesis. May act as a counter-receptor for CLEC10A in lymph node."},{"id":"ENSMUSP00000140783","abundance":0.797,"rank":11898,"name":"Lmbrd1","annotation":"Probable lysosomal cobalamin transporter; Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity); Belongs to the LIMR family. LMBRD1 subfamily."},{"id":"ENSMUSP00000059721","abundance":0.796,"rank":11899,"name":"Olfr722","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000104030","abundance":0.796,"rank":11900,"name":"Hnf4g","annotation":"Hepatocyte nuclear factor 4-gamma; Transcription factor. Has a lower transcription activation potential than HNF4-alpha (By similarity); Belongs to the nuclear hormone receptor family. NR2 subfamily."},{"id":"ENSMUSP00000044898","abundance":0.796,"rank":11901,"name":"Scaf11","annotation":"SR-related CTD-associated factor 11."},{"id":"ENSMUSP00000036003","abundance":0.795,"rank":11902,"name":"Tanc1","annotation":"Protein TANC1; May be a scaffold component in the postsynaptic density."},{"id":"ENSMUSP00000031817","abundance":0.795,"rank":11903,"name":"Herc6","annotation":"E3 ISG15--protein ligase Herc6; Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon."},{"id":"ENSMUSP00000056923","abundance":0.795,"rank":11904,"name":"Zbtb11","annotation":"Zinc finger and BTB domain-containing protein 11; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000027470","abundance":0.795,"rank":11905,"name":"Chrng","annotation":"Acetylcholine receptor subunit gamma; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Gamma/CHRNG sub- subfamily."},{"id":"ENSMUSP00000024657","abundance":0.794,"rank":11906,"name":"Phf10","annotation":"PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes.  [...] "},{"id":"ENSMUSP00000032902","abundance":0.794,"rank":11907,"name":"Calcb","annotation":"Calcitonin gene-related peptide 2; CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (By similarity)."},{"id":"ENSMUSP00000038915","abundance":0.794,"rank":11908,"name":"Rhou","annotation":"Rho-related GTP-binding protein RhoU; Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity)."},{"id":"ENSMUSP00000044108","abundance":0.793,"rank":11909,"name":"Mettl22","annotation":"Methyltransferase-like protein 22; Protein N-lysine methyltransferase. In vitro methylates KIN (By similarity)."},{"id":"ENSMUSP00000084062","abundance":0.793,"rank":11910,"name":"Hes6","annotation":"Transcription cofactor HES-6; Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up- regulate transcription in its presence. Promotes cell differentiation."},{"id":"ENSMUSP00000120967","abundance":0.793,"rank":11911,"name":"Ucp2","annotation":"Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000077123","abundance":0.793,"rank":11912,"name":"Osbpl6","annotation":"Oxysterol-binding protein-related protein 6; Regulates cellular transport and efflux of cholesterol (By similarity). Plays a role in phosphatidylinositol-4-phophate (PI4P) turnover at the neuronal membrane. Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid. Weakly binds 25-hydroxycholesterol (By similarity)."},{"id":"ENSMUSP00000112903","abundance":0.793,"rank":11913,"name":"Rnft2","annotation":"RING finger and transmembrane domain-containing protein 2."},{"id":"ENSMUSP00000031005","abundance":0.792,"rank":11914,"name":"Evc","annotation":"Ellis-van Creveld syndrome protein homolog; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development."},{"id":"ENSMUSP00000059678","abundance":0.792,"rank":11915,"name":"Zfp622","annotation":"Zinc finger protein 622; May behave as an activator of the bound transcription factor, MYBL2, and be involved in embryonic development."},{"id":"ENSMUSP00000156751","abundance":0.792,"rank":11916,"name":"Zfp53","annotation":"KRAB-containing zinc-finger protein KRAZ1."},{"id":"ENSMUSP00000021243","abundance":0.792,"rank":11917,"name":"Slc35b1","annotation":"Solute carrier family 35 member B1; Probable sugar transporter; Belongs to the nucleotide-sugar transporter family. SLC35B subfamily."},{"id":"ENSMUSP00000106567","abundance":0.791,"rank":11918,"name":"Mboat2","annotation":"Lysophospholipid acyltransferase 2; Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). To a lesser extent, also catalyzes the acylation of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3- phosphoethanolamine or PE) (LPEAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the  [...] "},{"id":"ENSMUSP00000033006","abundance":0.791,"rank":11919,"name":"Nsmce1","annotation":"Non-structural maintenance of chromosomes element 1 homolog; RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE [...] "},{"id":"ENSMUSP00000041793","abundance":0.791,"rank":11920,"name":"Elac1","annotation":"Zinc phosphodiesterase ELAC protein 1; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)."},{"id":"ENSMUSP00000158982","abundance":0.791,"rank":11921,"name":"Slc1a7","annotation":"Excitatory amino acid transporter 5; Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing (By similarity)."},{"id":"ENSMUSP00000034832","abundance":0.791,"rank":11922,"name":"Ptpn9","annotation":"Tyrosine-protein phosphatase non-receptor type 9; Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. Belongs to the protein-tyrosine phosphatase family. Non- receptor class 3 subfamily."},{"id":"ENSMUSP00000086606","abundance":0.79,"rank":11923,"name":"Cst7","annotation":"Cystatin-F; Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system."},{"id":"ENSMUSP00000031081","abundance":0.79,"rank":11924,"name":"Pi4k2b","annotation":"Phosphatidylinositol 4-kinase type 2-beta; Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the [...] "},{"id":"ENSMUSP00000018407","abundance":0.79,"rank":11925,"name":"Tbx5","annotation":"T-box transcription factor TBX5; DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter."},{"id":"ENSMUSP00000117533","abundance":0.79,"rank":11926,"name":"Csrnp3","annotation":"Cysteine/serine-rich nuclear protein 3; Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity. Plays a role in apoptosis. Belongs to the AXUD1 family."},{"id":"ENSMUSP00000158201","abundance":0.79,"rank":11927,"name":"Kctd16","annotation":"BTB/POZ domain-containing protein KCTD16; Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization."},{"id":"ENSMUSP00000093021","abundance":0.789,"rank":11928,"name":"Tex24","annotation":"Protein Tex24; Nuclear factor which might have a role in spermatogenesis."},{"id":"ENSMUSP00000112077","abundance":0.789,"rank":11929,"name":"Sh3bp5l","annotation":"SH3 domain-binding protein 5-like; Functions as guanine nucleotide exchange factor (GEF) for RAB11A."},{"id":"ENSMUSP00000077586","abundance":0.789,"rank":11930,"name":"Cacna1h","annotation":"Voltage-dependent T-type calcium channel subunit alpha-1H; Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal  [...] "},{"id":"ENSMUSP00000035980","abundance":0.789,"rank":11931,"name":"Arhgef4","annotation":"Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression."},{"id":"ENSMUSP00000063244","abundance":0.789,"rank":11932,"name":"1700030K09Rik","annotation":"Uncharacterized protein C19orf44 homolog."},{"id":"ENSMUSP00000037543","abundance":0.788,"rank":11933,"name":"Spg11","annotation":"Spatacsin; May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport."},{"id":"ENSMUSP00000071495","abundance":0.788,"rank":11934,"name":"Fbh1","annotation":"F-box DNA helicase 1; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: t [...] "},{"id":"ENSMUSP00000023494","abundance":0.788,"rank":11935,"name":"Popdc2","annotation":"Popeye domain-containing protein 2; Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density."},{"id":"ENSMUSP00000034746","abundance":0.787,"rank":11936,"name":"Mns1","annotation":"Meiosis-specific nuclear structural protein 1; May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis."},{"id":"ENSMUSP00000104865","abundance":0.787,"rank":11937,"name":"Pkd1l3","annotation":"Polycystic kidney disease protein 1-like 3; Component of a calcium channel. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect. Belongs to the polycystin family."},{"id":"ENSMUSP00000055892","abundance":0.787,"rank":11938,"name":"Tmem64","annotation":"Transmembrane protein 64; Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates [...] "},{"id":"ENSMUSP00000025395","abundance":0.787,"rank":11939,"name":"Grp","annotation":"Gastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake. Belongs to the bombesin/neuromedin-B/ranatensin family."},{"id":"ENSMUSP00000025497","abundance":0.787,"rank":11940,"name":"Fbn2","annotation":"Fibrillin-2 C-terminal peptide; [Fibrillin-2]: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively."},{"id":"ENSMUSP00000009358","abundance":0.787,"rank":11941,"name":"Mymk","annotation":"Protein myomaker; Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers. Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX. Acts independently of MYMX. Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers. Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers. Belong [...] "},{"id":"ENSMUSP00000039517","abundance":0.787,"rank":11942,"name":"Brsk1","annotation":"Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-504' and 'Ser-554'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 [...] "},{"id":"ENSMUSP00000045873","abundance":0.787,"rank":11943,"name":"Anln","annotation":"Anillin; Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration."},{"id":"ENSMUSP00000114026","abundance":0.786,"rank":11944,"name":"Lrp3","annotation":"Low density lipoprotein receptor-related protein 3."},{"id":"ENSMUSP00000108413","abundance":0.786,"rank":11945,"name":"Cacna1c","annotation":"Voltage-dependent L-type calcium channel subunit alpha-1C; Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via  [...] "},{"id":"ENSMUSP00000072585","abundance":0.786,"rank":11946,"name":"Zfp954","annotation":"Zinc finger protein 954."},{"id":"ENSMUSP00000154588","abundance":0.785,"rank":11947,"name":"Vmn1r11","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000098943","abundance":0.785,"rank":11948,"name":"Hoxa4","annotation":"Homeobox protein Hox-A4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'; Belongs to the Antp homeobox family. Deformed subfamily."},{"id":"ENSMUSP00000048043","abundance":0.785,"rank":11949,"name":"Rccd1","annotation":"RCC1 domain-containing protein 1; Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta- induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8."},{"id":"ENSMUSP00000048129","abundance":0.785,"rank":11950,"name":"Ifi207","annotation":"Interferon-activated gene 207."},{"id":"ENSMUSP00000056364","abundance":0.784,"rank":11951,"name":"Lhfp","annotation":"LHFPL tetraspan subfamily member 6 protein."},{"id":"ENSMUSP00000126439","abundance":0.783,"rank":11952,"name":"Mfsd4b5","annotation":"Major facilitator superfamily domain-containing 4B5."},{"id":"ENSMUSP00000034465","abundance":0.783,"rank":11953,"name":"2810004N23Rik","annotation":"Uncharacterized protein C1orf131 homolog."},{"id":"ENSMUSP00000048603","abundance":0.783,"rank":11954,"name":"Cog6","annotation":"Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function."},{"id":"ENSMUSP00000099799","abundance":0.783,"rank":11955,"name":"Kti12","annotation":"Protein KTI12 homolog; Belongs to the KTI12 family."},{"id":"ENSMUSP00000048901","abundance":0.782,"rank":11956,"name":"Mvb12b","annotation":"Multivesicular body subunit 12B; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity)."},{"id":"ENSMUSP00000037214","abundance":0.782,"rank":11957,"name":"Arl5c","annotation":"ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP."},{"id":"ENSMUSP00000110077","abundance":0.782,"rank":11958,"name":"Hoxa3","annotation":"Homeobox protein Hox-A3; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds 5' to its own homeobox."},{"id":"ENSMUSP00000026997","abundance":0.781,"rank":11959,"name":"Uimc1","annotation":"BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double- strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin.  [...] "},{"id":"ENSMUSP00000020982","abundance":0.781,"rank":11960,"name":"Klf11","annotation":"Krueppel-like factor 11; Transcription factor. Activates the epsilon- and gamma-globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding sites inhibiting cell growth (By similarity). Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis."},{"id":"ENSMUSP00000073700","abundance":0.781,"rank":11961,"name":"Klra6","annotation":"Killer cell lectin-like receptor 6; Receptor on natural killer (NK) cells for class I MHC."},{"id":"ENSMUSP00000020926","abundance":0.781,"rank":11962,"name":"Lratd1","annotation":"Protein LRATD1; May play a role in cell morphology and motility. Belongs to the LRATD family."},{"id":"ENSMUSP00000134337","abundance":0.781,"rank":11963,"name":"Scnm1","annotation":"Sodium channel modifier 1; Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites."},{"id":"ENSMUSP00000095977","abundance":0.781,"rank":11964,"name":"Pkd1l2","annotation":"Polycystic kidney disease protein 1-like 2; May function as an ion-channel regulator. May function as a G-protein-coupled receptor (By similarity)."},{"id":"ENSMUSP00000080278","abundance":0.781,"rank":11965,"name":"Mtf2","annotation":"Metal-response element-binding transcription factor 2; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated [...] "},{"id":"ENSMUSP00000138735","abundance":0.781,"rank":11966,"name":"Slc8a3","annotation":"Sodium/calcium exchanger 3; Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels r [...] "},{"id":"ENSMUSP00000057095","abundance":0.78,"rank":11967,"name":"Spata2","annotation":"Spermatogenesis-associated protein 2; Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis (By similarity). Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC) (By similarity). Required to activate the 'Met- 1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha- induced necroptosis by promoting 'Met-1 [...] "},{"id":"ENSMUSP00000074471","abundance":0.78,"rank":11968,"name":"Irak4","annotation":"Interleukin-1 receptor-associated kinase 4; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquiti [...] "},{"id":"ENSMUSP00000073228","abundance":0.78,"rank":11969,"name":"Nrap","annotation":"Nebulin-related-anchoring protein; May be involved in anchoring the terminal actin filaments in the myofibril to the membrane and in transmitting tension from the myofibrils to the extracellular matrix."},{"id":"ENSMUSP00000022819","abundance":0.78,"rank":11970,"name":"Jph4","annotation":"Junctophilin-4; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory."},{"id":"ENSMUSP00000024761","abundance":0.78,"rank":11971,"name":"Fbxl17","annotation":"F-box/LRR-repeat protein 17; Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (By similarity). The ability of the SCF(FBXL17) complex to eliminate co [...] "},{"id":"ENSMUSP00000078910","abundance":0.779,"rank":11972,"name":"Zfand2a","annotation":"AN1-type zinc finger protein 2A."},{"id":"ENSMUSP00000112581","abundance":0.779,"rank":11973,"name":"Kbtbd12","annotation":"Kelch repeat and BTB domain-containing protein 12."},{"id":"ENSMUSP00000119711","abundance":0.779,"rank":11974,"name":"Plekhd1","annotation":"Pleckstrin homology domain-containing family D member 1; Belongs to the PLEKHD1 family."},{"id":"ENSMUSP00000143083","abundance":0.778,"rank":11975,"name":"Asic3","annotation":"Acid-sensing ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC3 subfamily."},{"id":"ENSMUSP00000018795","abundance":0.778,"rank":11976,"name":"Tada2a","annotation":"Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (By similarity). May also promote XRCC6  [...] "},{"id":"ENSMUSP00000147873","abundance":0.778,"rank":11977,"name":"Zfp474","annotation":"Zinc finger protein 474."},{"id":"ENSMUSP00000141865","abundance":0.778,"rank":11978,"name":"Sema3f","annotation":"Semaphorin-3F."},{"id":"ENSMUSP00000137973","abundance":0.778,"rank":11979,"name":"Tnfsfm13","annotation":"Tumor necrosis factor (ligand) superfamily, membrane-bound member 13; Belongs to the tumor necrosis factor family."},{"id":"ENSMUSP00000146518","abundance":0.778,"rank":11980,"name":"Zfand6","annotation":"AN1-type zinc finger protein 6; Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1 (By similarity). Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes."},{"id":"ENSMUSP00000149259","abundance":0.778,"rank":11981,"name":"Olfr818","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149053","abundance":0.778,"rank":11982,"name":"Olfr318","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000047839","abundance":0.777,"rank":11983,"name":"Ppp1r13l","annotation":"RelA-associated inhibitor; Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (By similarity)."},{"id":"ENSMUSP00000104449","abundance":0.777,"rank":11984,"name":"2210407C18Rik","annotation":"RIKEN cDNA 2210407C18 gene."},{"id":"ENSMUSP00000156959","abundance":0.777,"rank":11985,"name":"Lhfpl5","annotation":"LHFPL tetraspan subfamily member 5 protein; In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation; Belongs to the LHFP family."},{"id":"ENSMUSP00000026744","abundance":0.777,"rank":11986,"name":"Tmem89","annotation":"Transmembrane protein 89."},{"id":"ENSMUSP00000107444","abundance":0.777,"rank":11987,"name":"Calhm1","annotation":"Calcium homeostasis modulator protein 1; Pore-forming subunit of a voltage-gated ion channel, also permeable to larger molecules including ATP, required for sensory perception of sweet, bitter and umami tastes. Specifically present in type II taste bud cells, where it plays a central role in sweet, bitter and umami taste perception by inducing ATP release from the cell, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Together with CALHM3, forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells (TBCs). Acts both as a voltage- [...] "},{"id":"ENSMUSP00000059658","abundance":0.777,"rank":11988,"name":"She","annotation":"SH2 domain-containing adapter protein E."},{"id":"ENSMUSP00000022469","abundance":0.777,"rank":11989,"name":"Nisch","annotation":"Nischarin; Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell- signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mi [...] "},{"id":"ENSMUSP00000058437","abundance":0.777,"rank":11990,"name":"Teddm1b","annotation":"Transmembrane epididymal protein 1B."},{"id":"ENSMUSP00000045196","abundance":0.776,"rank":11991,"name":"Muc3","annotation":"Mucin 3, intestinal."},{"id":"ENSMUSP00000051297","abundance":0.776,"rank":11992,"name":"Ndnf","annotation":"Protein NDNF; Promotes neuron migration, growth and survival as well as neurite outgrowth (By similarity). Promotes matrix assembly and cell adhesiveness. Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms."},{"id":"ENSMUSP00000009321","abundance":0.776,"rank":11993,"name":"Dgcr8","annotation":"Microprocessor complex subunit DGCR8; Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA- ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs tha [...] "},{"id":"ENSMUSP00000026032","abundance":0.776,"rank":11994,"name":"Pcgf6","annotation":"Polycomb group RING finger protein 6; Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 [...] "},{"id":"ENSMUSP00000130065","abundance":0.775,"rank":11995,"name":"Nat2","annotation":"Arylamine N-acetyltransferase 2; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. 2-aminofluorene and p-aminobenzoic acid (PABA) are preferred substrates for NAT-2. Less activity with anisidine and barely detectable with SMZ."},{"id":"ENSMUSP00000117169","abundance":0.775,"rank":11996,"name":"Dact1","annotation":"Dapper homolog 1; Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane l [...] "},{"id":"ENSMUSP00000109236","abundance":0.775,"rank":11997,"name":"Hmces","annotation":"Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (By similarity). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA (By similarity). The HMCES DNA-protein cross-link is then degraded by the proteasome (By similarity). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from tr [...] "},{"id":"ENSMUSP00000039073","abundance":0.775,"rank":11998,"name":"Zfp446","annotation":"Zinc finger protein 446."},{"id":"ENSMUSP00000023221","abundance":0.774,"rank":11999,"name":"Gpaa1","annotation":"Glycosylphosphatidylinositol anchor attachment 1 protein; Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate."},{"id":"ENSMUSP00000103171","abundance":0.774,"rank":12000,"name":"Shoc1","annotation":"Protein shortage in chiasmata 1 ortholog; ATPase required during meiosis for the formation of crossover recombination intermediates. Binds DNA: preferentially binds to single-stranded DNA and DNA branched structures (By similarity). Does not show nuclease activity in vitro, but shows ATPase activity, which is stimulated by the presence of single-stranded DNA (By similarity)."},{"id":"ENSMUSP00000114173","abundance":0.774,"rank":12001,"name":"Pou6f2","annotation":"POU domain, class 6, transcription factor 2; Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3' (By similarity). Belongs to the POU transcription factor family. Class-6 subfamily."},{"id":"ENSMUSP00000062433","abundance":0.774,"rank":12002,"name":"Cep120","annotation":"Centrosomal protein of 120 kDa; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during e [...] "},{"id":"ENSMUSP00000099604","abundance":0.774,"rank":12003,"name":"Arhgap11a","annotation":"Rho GTPase-activating protein 11A."},{"id":"ENSMUSP00000062047","abundance":0.774,"rank":12004,"name":"Uaca","annotation":"Uveal autoantigen with coiled-coil domains and ankyrin repeats; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1."},{"id":"ENSMUSP00000150247","abundance":0.774,"rank":12005,"name":"Olfr1047","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000036228","abundance":0.774,"rank":12006,"name":"Slc7a13","annotation":"Solute carrier family 7 member 13; Mediates the transport L-aspartate and L-glutamate in a sodium-independent manner."},{"id":"ENSMUSP00000129146","abundance":0.774,"rank":12007,"name":"Tns2","annotation":"Tensin-2; Tyrosine-protein phosphatase which regulates cell motility proliferation and muscle-response to insulin. In muscles and under catabolic conditions, dephosphorylates IRS1 leading to its degradation and muscle atrophy. Negatively regulates PI3K-AKT pathway activation. Belongs to the PTEN phosphatase protein family."},{"id":"ENSMUSP00000009236","abundance":0.773,"rank":12008,"name":"Derl3","annotation":"Derlin-3; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins. May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the e [...] "},{"id":"ENSMUSP00000079208","abundance":0.773,"rank":12009,"name":"Cfap299","annotation":"Cilia- and flagella-associated protein 299; May be involved in spermatogenesis."},{"id":"ENSMUSP00000099964","abundance":0.772,"rank":12010,"name":"Abo","annotation":"Histo-blood group ABO system transferase."},{"id":"ENSMUSP00000031852","abundance":0.772,"rank":12011,"name":"4921507P07Rik","annotation":"Uncharacterized protein C7orf31 homolog."},{"id":"ENSMUSP00000151739","abundance":0.772,"rank":12012,"name":"Olfr589","annotation":"Olfactory receptor MOR32-3."},{"id":"ENSMUSP00000000445","abundance":0.772,"rank":12013,"name":"Myf5","annotation":"Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein."},{"id":"ENSMUSP00000103592","abundance":0.772,"rank":12014,"name":"Fam214b","annotation":"Protein FAM214B; Belongs to the FAM214 family."},{"id":"ENSMUSP00000024179","abundance":0.771,"rank":12015,"name":"Nfatc4","annotation":"Nuclear factor of activated T-cells, cytoplasmic 4; Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4. Along with NFATC3, involved in embryonic heart development. Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function. Transactivates many genes involved in heart physiology. Along with GATA4, binds to and acti [...] "},{"id":"ENSMUSP00000048562","abundance":0.771,"rank":12016,"name":"Fbxl16","annotation":"F-box/LRR-repeat protein 16; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000045281","abundance":0.771,"rank":12017,"name":"Pbx3","annotation":"Pre-B-cell leukemia transcription factor 3; Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'; Belongs to the TALE/PBX homeobox family."},{"id":"ENSMUSP00000103608","abundance":0.771,"rank":12018,"name":"Iglon5","annotation":"IgLON family member 5."},{"id":"ENSMUSP00000024270","abundance":0.771,"rank":12019,"name":"Cdca3","annotation":"Cell division cycle-associated protein 3; F-box-like protein which is required for entry into mitosis. Acts by participating in E3 ligase complexes that mediate the ubiquitination and degradation of WEE1 kinase at G2/M phase (By similarity)."},{"id":"ENSMUSP00000102227","abundance":0.771,"rank":12020,"name":"Cdc42ep4","annotation":"Cdc42 effector protein 4; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts; Belongs to the BORG/CEP family."},{"id":"ENSMUSP00000095608","abundance":0.771,"rank":12021,"name":"Fam53b","annotation":"Protein FAM53B; Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) nuclear localization. Belongs to the FAM53 family."},{"id":"ENSMUSP00000003320","abundance":0.77,"rank":12022,"name":"Eif2b5","annotation":"Translation initiation factor eIF-2B subunit epsilon; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B gamma/epsilon subunits family."},{"id":"ENSMUSP00000031127","abundance":0.77,"rank":12023,"name":"Slc10a4","annotation":"Sodium/bile acid cotransporter 4; Transporter for bile acids; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family."},{"id":"ENSMUSP00000073302","abundance":0.77,"rank":12024,"name":"Glipr1l1","annotation":"GLIPR1-like protein 1; Plays a role in the binding between sperm and oocytes. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region."},{"id":"ENSMUSP00000043828","abundance":0.77,"rank":12025,"name":"Hdac11","annotation":"Histone deacetylase 11; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity)."},{"id":"ENSMUSP00000137484","abundance":0.77,"rank":12026,"name":"Scgb2b20","annotation":"Secretoglobin family 2B member 20; Belongs to the secretoglobin family."},{"id":"ENSMUSP00000052944","abundance":0.77,"rank":12027,"name":"Zfp764","annotation":"Zinc finger protein 764."},{"id":"ENSMUSP00000025749","abundance":0.769,"rank":12028,"name":"Rps6kb2","annotation":"Ribosomal protein S6 kinase beta-2; Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7."},{"id":"ENSMUSP00000141792","abundance":0.769,"rank":12029,"name":"Pcdh15","annotation":"Protocadherin-15; Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function."},{"id":"ENSMUSP00000149687","abundance":0.769,"rank":12030,"name":"Olfr62","annotation":"Olfactory receptor 62."},{"id":"ENSMUSP00000053783","abundance":0.769,"rank":12031,"name":"Ankrd13d","annotation":"Ankyrin repeat domain-containing protein 13D; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity)."},{"id":"ENSMUSP00000053305","abundance":0.769,"rank":12032,"name":"BC024139","annotation":"cDNA sequence BC024139."},{"id":"ENSMUSP00000083229","abundance":0.769,"rank":12033,"name":"Olfr145","annotation":"Olfactory receptor 145; Odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000018990","abundance":0.769,"rank":12034,"name":"Pank3","annotation":"Pantothenate kinase 3; Plays a role in the physiological regulation of coenzyme A (CoA) levels; Belongs to the type II pantothenate kinase family."},{"id":"ENSMUSP00000106518","abundance":0.768,"rank":12035,"name":"Tatdn3","annotation":"Putative deoxyribonuclease TATDN3; Putative deoxyribonuclease; Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family."},{"id":"ENSMUSP00000121202","abundance":0.768,"rank":12036,"name":"Zfp85","annotation":"Zinc finger protein 85, related sequence 1."},{"id":"ENSMUSP00000111256","abundance":0.768,"rank":12037,"name":"Deup1","annotation":"Deuterosome assembly protein 1; Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis."},{"id":"ENSMUSP00000045724","abundance":0.768,"rank":12038,"name":"Fam222a","annotation":"Protein FAM222A; Belongs to the FAM222 family."},{"id":"ENSMUSP00000021750","abundance":0.768,"rank":12039,"name":"Ryr2","annotation":"Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. Belongs to the ryanodine rec [...] "},{"id":"ENSMUSP00000035332","abundance":0.767,"rank":12040,"name":"Mab21l4","annotation":"Protein mab-21-like 4."},{"id":"ENSMUSP00000001599","abundance":0.767,"rank":12041,"name":"Klhl10","annotation":"Kelch-like protein 10; May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis. Required for male fertility."},{"id":"ENSMUSP00000100541","abundance":0.766,"rank":12042,"name":"Mageb3","annotation":"Melanoma antigen, family B, 3."},{"id":"ENSMUSP00000018792","abundance":0.766,"rank":12043,"name":"Dusp14","annotation":"Dual specificity protein phosphatase 14; Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000032570","abundance":0.766,"rank":12044,"name":"Dmwd","annotation":"Dystrophia myotonica WD repeat-containing protein."},{"id":"ENSMUSP00000128661","abundance":0.765,"rank":12045,"name":"Odc1","annotation":"Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis."},{"id":"ENSMUSP00000008032","abundance":0.765,"rank":12046,"name":"Crlf1","annotation":"Cytokine receptor-like factor 1; In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity). Plays a role in the initiation and/or maintenance of suckling in neonatal mice. May also play a regulatory role in the immune system (By similarity)."},{"id":"ENSMUSP00000121000","abundance":0.764,"rank":12047,"name":"Tdg","annotation":"G/T mismatch-specific thymine DNA glycosylase; DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. Cannot remove 5- hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC. Also involved in DNA repair by acting as a thy [...] "},{"id":"ENSMUSP00000098262","abundance":0.764,"rank":12048,"name":"Gm3633","annotation":"Predicted gene 3633."},{"id":"ENSMUSP00000075507","abundance":0.764,"rank":12049,"name":"Ackr4","annotation":"Atypical chemokine receptor 4; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin [...] "},{"id":"ENSMUSP00000039271","abundance":0.764,"rank":12050,"name":"Fcsk","annotation":"L-fucose kinase; Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.  [Isoform 2]: Has very weak fucokinase activity. Belongs to the GHMP kinase family."},{"id":"ENSMUSP00000101714","abundance":0.763,"rank":12051,"name":"Zmym4","annotation":"Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization."},{"id":"ENSMUSP00000059426","abundance":0.763,"rank":12052,"name":"A2ml1","annotation":"Ovostatin homolog; Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism."},{"id":"ENSMUSP00000021271","abundance":0.763,"rank":12053,"name":"Per1","annotation":"Period circadian protein homolog 1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardi [...] "},{"id":"ENSMUSP00000033485","abundance":0.763,"rank":12054,"name":"Prickle3","annotation":"Prickle planar cell polarity protein 3; Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the orga [...] "},{"id":"ENSMUSP00000027846","abundance":0.763,"rank":12055,"name":"Tada1","annotation":"Transcriptional adapter 1; Probably involved in transcriptional regulation."},{"id":"ENSMUSP00000124201","abundance":0.763,"rank":12056,"name":"Herpud1","annotation":"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway."},{"id":"ENSMUSP00000019679","abundance":0.762,"rank":12057,"name":"Armc6","annotation":"Armadillo repeat-containing protein 6."},{"id":"ENSMUSP00000131126","abundance":0.762,"rank":12058,"name":"Lax1","annotation":"Lymphocyte transmembrane adapter 1; Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells."},{"id":"ENSMUSP00000027146","abundance":0.761,"rank":12059,"name":"Ikzf2","annotation":"Zinc finger protein Helios; Associates with Ikaros at centromeric heterochromatin."},{"id":"ENSMUSP00000142708","abundance":0.761,"rank":12060,"name":"Usp33","annotation":"Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the ne [...] "},{"id":"ENSMUSP00000087959","abundance":0.761,"rank":12061,"name":"Gpr88","annotation":"Probable G-protein coupled receptor 88; Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function."},{"id":"ENSMUSP00000105295","abundance":0.76,"rank":12062,"name":"Ncoa6","annotation":"Nuclear receptor coactivator 6; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Coactivates expression in an agonist- and AF2- dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. [...] "},{"id":"ENSMUSP00000067241","abundance":0.76,"rank":12063,"name":"Nav1","annotation":"Neuron navigator 1; May be involved in neuronal migration. Belongs to the Nav/unc-53 family."},{"id":"ENSMUSP00000039889","abundance":0.76,"rank":12064,"name":"Cep85","annotation":"Centrosomal protein of 85 kDa; Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity; Belongs to the CEP85 family."},{"id":"ENSMUSP00000106905","abundance":0.76,"rank":12065,"name":"Prdm11","annotation":"PR domain-containing protein 11; May be involved in transcription regulation. Belongs to the class V-like SAM-binding methyltransferase superfamily."},{"id":"ENSMUSP00000072237","abundance":0.76,"rank":12066,"name":"Tas2r104","annotation":"Taste receptor type 2 member 104; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000034609","abundance":0.759,"rank":12067,"name":"Treh","annotation":"Trehalase; Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose; Belongs to the glycosyl hydrolase 37 family."},{"id":"ENSMUSP00000070550","abundance":0.759,"rank":12068,"name":"9430038I01Rik","annotation":"Uncharacterized protein C10orf143 homolog."},{"id":"ENSMUSP00000093266","abundance":0.759,"rank":12069,"name":"Zfp213","annotation":"Zinc finger protein 213."},{"id":"ENSMUSP00000005488","abundance":0.759,"rank":12070,"name":"Casp14","annotation":"Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family."},{"id":"ENSMUSP00000076178","abundance":0.759,"rank":12071,"name":"Gpkow","annotation":"G-patch domain and KOW motifs-containing protein; RNA-binding protein involved in pre-mRNA splicing. Belongs to the MOS2 family."},{"id":"ENSMUSP00000083665","abundance":0.759,"rank":12072,"name":"Olfr872","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000150810","abundance":0.759,"rank":12073,"name":"Olfr1054","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000062245","abundance":0.758,"rank":12074,"name":"Spata46","annotation":"Spermatogenesis-associated protein 46; Plays a role in spermiogenesis and fertilization."},{"id":"ENSMUSP00000042334","abundance":0.758,"rank":12075,"name":"Plekhj1","annotation":"Pleckstrin homology domain-containing family J member 1."},{"id":"ENSMUSP00000099985","abundance":0.757,"rank":12076,"name":"Myl7","annotation":"Myosin regulatory light chain 2, atrial isoform."},{"id":"ENSMUSP00000151344","abundance":0.757,"rank":12077,"name":"Rnf212b","annotation":"RING finger protein 212B."},{"id":"ENSMUSP00000023129","abundance":0.757,"rank":12078,"name":"Gtsf1","annotation":"Gametocyte-specific factor 1; Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells."},{"id":"ENSMUSP00000109039","abundance":0.756,"rank":12079,"name":"2010106E10Rik","annotation":"RIKEN cDNA 2010106E10 gene."},{"id":"ENSMUSP00000028796","abundance":0.756,"rank":12080,"name":"Rpusd2","annotation":"RNA pseudouridylate synthase domain-containing protein 2; Belongs to the pseudouridine synthase RluA family."},{"id":"ENSMUSP00000086703","abundance":0.755,"rank":12081,"name":"Arl13b","annotation":"ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule- based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic intern [...] "},{"id":"ENSMUSP00000124312","abundance":0.755,"rank":12082,"name":"Ssh1","annotation":"Protein phosphatase Slingshot homolog 1; Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein."},{"id":"ENSMUSP00000129326","abundance":0.755,"rank":12083,"name":"Scgb1b20","annotation":"Secretoglobin, family 1B, member 20."},{"id":"ENSMUSP00000103729","abundance":0.755,"rank":12084,"name":"Scgb1b29","annotation":"Secretoglobin, family 1B, member 29."},{"id":"ENSMUSP00000103732","abundance":0.755,"rank":12085,"name":"Scgb1b7","annotation":"Secretoglobin, family 1B, member 7."},{"id":"ENSMUSP00000126541","abundance":0.755,"rank":12086,"name":"Stk35","annotation":"Serine/threonine-protein kinase 35."},{"id":"ENSMUSP00000075455","abundance":0.755,"rank":12087,"name":"Vmn1r53","annotation":"Vomeronasal type-1 receptor 53; Putative pheromone receptor implicated in the regulation of social and reproductive behavior."},{"id":"ENSMUSP00000104131","abundance":0.755,"rank":12088,"name":"Ceacam3","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 3."},{"id":"ENSMUSP00000112385","abundance":0.755,"rank":12089,"name":"Trip4","annotation":"Activating signal cointegrator 1; Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (By similarity). Also involved in androgen receptor transactivation. Plays a pivotal role in the transactivation of NF-kap [...] "},{"id":"ENSMUSP00000127173","abundance":0.755,"rank":12090,"name":"Pdgfra","annotation":"Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointes [...] "},{"id":"ENSMUSP00000132822","abundance":0.754,"rank":12091,"name":"Xpnpep3","annotation":"Xaa-Pro aminopeptidase 3; Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides, such as Leu-Pro-Ala. Also shows low activity towards peptides with Ala or Ser at the P1 position. Promotes TNFRSF1B- mediated phosphorylation of MAPK8/JNK1 and MAPK9/JNK2, suggesting a function as an adapter protein for TNFRSF1B; the effect is independent of XPNPEP3 peptidase activity. May inhibit apoptotic cell death induced via TNF-TNFRSF1B signaling."},{"id":"ENSMUSP00000059371","abundance":0.754,"rank":12092,"name":"Gimap6","annotation":"GTPase IMAP family member 6; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily."},{"id":"ENSMUSP00000027532","abundance":0.754,"rank":12093,"name":"Scly","annotation":"Selenocysteine lyase; Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family."},{"id":"ENSMUSP00000020530","abundance":0.753,"rank":12094,"name":"Nprl3","annotation":"GATOR complex protein NPRL3; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway."},{"id":"ENSMUSP00000020188","abundance":0.753,"rank":12095,"name":"Ifngr1","annotation":"Interferon gamma receptor 1; Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway (By similarity)."},{"id":"ENSMUSP00000032892","abundance":0.753,"rank":12096,"name":"Xylt1","annotation":"Xylosyltransferase 1; Catalyzes the first step in the biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D- xylose from UDP-D-xylose to specific serine residues of the core protein. Required for normal maturation of chondrocytes during bone development, normal onset of ossification and normal embryonic and postnatal skeleton development, especially of the long bones."},{"id":"ENSMUSP00000036031","abundance":0.753,"rank":12097,"name":"Rhod","annotation":"Rho-related GTP-binding protein RhoD; Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. Belongs to the small GTPase superfamily. Rho family."},{"id":"ENSMUSP00000035281","abundance":0.753,"rank":12098,"name":"Ptov1","annotation":"Prostate tumor-overexpressed gene 1 protein homolog; May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation (By similarity)."},{"id":"ENSMUSP00000099779","abundance":0.753,"rank":12099,"name":"Ttc21b","annotation":"Tetratricopeptide repeat protein 21B; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs). Essential for retrograde trafficking of IFT- 1, IFT-B and GPCRs (By similarity). Negatively modulates the SHH signal transduction ; Belongs to the TTC21 family."},{"id":"ENSMUSP00000028934","abundance":0.753,"rank":12100,"name":"Cst11","annotation":"Cystatin-11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization. Belongs to the cystatin family."},{"id":"ENSMUSP00000077616","abundance":0.752,"rank":12101,"name":"Taar7a","annotation":"Trace amine-associated receptor 7a; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000022458","abundance":0.752,"rank":12102,"name":"Bap1","annotation":"Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chain [...] "},{"id":"ENSMUSP00000090747","abundance":0.752,"rank":12103,"name":"Pabpn1l","annotation":"Embryonic polyadenylate-binding protein 2; Binds the poly(A) tail of mRNA."},{"id":"ENSMUSP00000056040","abundance":0.752,"rank":12104,"name":"Dscam","annotation":"Down syndrome cell adhesion molecule homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self- avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. Might also  [...] "},{"id":"ENSMUSP00000074903","abundance":0.751,"rank":12105,"name":"Chic2","annotation":"Cysteine-rich hydrophobic domain-containing protein 2; Belongs to the CHIC family."},{"id":"ENSMUSP00000022048","abundance":0.751,"rank":12106,"name":"Slc6a19","annotation":"Sodium-dependent neutral amino acid transporter B(0)AT1; Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells. This uptake is sodium-dependent and chloride- independent. Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A19 subfamily."},{"id":"ENSMUSP00000046960","abundance":0.751,"rank":12107,"name":"Il17f","annotation":"Interleukin-17F; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (By similarity). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (By similarity). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.  [...] "},{"id":"ENSMUSP00000078287","abundance":0.751,"rank":12108,"name":"Lypd4","annotation":"Ly6/PLAUR domain-containing protein 4."},{"id":"ENSMUSP00000054488","abundance":0.751,"rank":12109,"name":"Insl6","annotation":"Insulin-like peptide INSL6 A chain; May have a role in sperm development and fertilization; Belongs to the insulin family."},{"id":"ENSMUSP00000032803","abundance":0.751,"rank":12110,"name":"Zfp30","annotation":"Zinc finger protein 30; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000104457","abundance":0.751,"rank":12111,"name":"Zfp672","annotation":"Zinc finger protein 672; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000110357","abundance":0.751,"rank":12112,"name":"Bivm","annotation":"Basic immunoglobulin-like variable motif-containing protein."},{"id":"ENSMUSP00000038721","abundance":0.75,"rank":12113,"name":"Alkbh3","annotation":"Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (By similarity). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal m [...] "},{"id":"ENSMUSP00000041912","abundance":0.75,"rank":12114,"name":"Erf","annotation":"ETS domain-containing transcription factor ERF; Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation (By similarity). Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. May be important for regulating trophoblast stem cell differentiation."},{"id":"ENSMUSP00000055692","abundance":0.75,"rank":12115,"name":"Fbxo46","annotation":"F-box only protein 46; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000154404","abundance":0.75,"rank":12116,"name":"Vmn1r1","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000043918","abundance":0.75,"rank":12117,"name":"Bace2","annotation":"Beta-secretase 2; Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 (By similarity). Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (By similarity)."},{"id":"ENSMUSP00000115078","abundance":0.749,"rank":12118,"name":"Svil","annotation":"Supervillin; [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function."},{"id":"ENSMUSP00000113755","abundance":0.749,"rank":12119,"name":"Klhl14","annotation":"Kelch-like protein 14."},{"id":"ENSMUSP00000129183","abundance":0.749,"rank":12120,"name":"Insyn2b","annotation":"INSYN2B protein; Belongs to the INSYN2 family."},{"id":"ENSMUSP00000034041","abundance":0.749,"rank":12121,"name":"Irf2","annotation":"Interferon regulatory factor 2; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation."},{"id":"ENSMUSP00000059709","abundance":0.749,"rank":12122,"name":"Cyb5d1","annotation":"Cytochrome b5 domain-containing protein 1."},{"id":"ENSMUSP00000145803","abundance":0.748,"rank":12123,"name":"Cd19","annotation":"B-lymphocyte antigen CD19; Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (By similarity). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in  [...] "},{"id":"ENSMUSP00000103825","abundance":0.748,"rank":12124,"name":"Wdr62","annotation":"WD repeat-containing protein 62; Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (By similarity). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity)."},{"id":"ENSMUSP00000137520","abundance":0.747,"rank":12125,"name":"Adgrg1","annotation":"Adhesion G-protein coupled receptor G1; Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity). Plays a role in the maintenance of hematopoie [...] "},{"id":"ENSMUSP00000037385","abundance":0.747,"rank":12126,"name":"Lepr","annotation":"Leptin receptor; Receptor for hormone LEP/leptin (Probable). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite- regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive fu [...] "},{"id":"ENSMUSP00000073453","abundance":0.747,"rank":12127,"name":"E2f7","annotation":"Transcription factor E2F7; Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in po [...] "},{"id":"ENSMUSP00000113898","abundance":0.747,"rank":12128,"name":"R3hcc1","annotation":"R3H and coiled-coil domain-containing protein 1."},{"id":"ENSMUSP00000038476","abundance":0.747,"rank":12129,"name":"AW549877","annotation":"UPF0600 protein C5orf51 homolog."},{"id":"ENSMUSP00000126114","abundance":0.746,"rank":12130,"name":"Gabra6","annotation":"Gamma-aminobutyric acid receptor subunit alpha-6; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel."},{"id":"ENSMUSP00000107869","abundance":0.746,"rank":12131,"name":"Cacna1d","annotation":"Voltage-dependent L-type calcium channel subunit alpha-1D; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines."},{"id":"ENSMUSP00000020938","abundance":0.746,"rank":12132,"name":"Fam20a","annotation":"Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals."},{"id":"ENSMUSP00000039072","abundance":0.746,"rank":12133,"name":"Jph1","annotation":"Junctophilin-1; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes."},{"id":"ENSMUSP00000088209","abundance":0.746,"rank":12134,"name":"Olfr1145","annotation":"Olfactory receptor 1145."},{"id":"ENSMUSP00000097740","abundance":0.746,"rank":12135,"name":"Hoxc4","annotation":"Homeobox protein Hox-C4; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Deformed subfamily."},{"id":"ENSMUSP00000045740","abundance":0.745,"rank":12136,"name":"Secisbp2","annotation":"SECIS-binding protein 2."},{"id":"ENSMUSP00000073502","abundance":0.745,"rank":12137,"name":"Lrrc10","annotation":"Leucine-rich repeat-containing protein 10; May play important roles in cardiac development and/or cardiac function."},{"id":"ENSMUSP00000103518","abundance":0.744,"rank":12138,"name":"Rgp1","annotation":"RAB6A-GEF complex partner protein 2; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors."},{"id":"ENSMUSP00000076189","abundance":0.744,"rank":12139,"name":"Trim30a","annotation":"Tripartite motif-containing protein 30A; Trans-acting factor that regulates gene expression of interleukin 2 receptor alpha chain. May affect IL2R-alpha expression through cis-acting negative regulatory elements or through competition with proteins that bind to enhancer or activator sequences. Negatively regulates Toll-like receptor (TLR)-mediated activation of NFKB by promoting degradation of TAB2 and TAB3 and preventing TRAF6 autoubiquitination. Negatively regulates production of reactive oxygen species (ROS) which inhibits activation of the NLRP3 inflammasome complex. This, in turn, [...] "},{"id":"ENSMUSP00000057891","abundance":0.744,"rank":12140,"name":"Ccdc71","annotation":"Coiled-coil domain-containing protein 71."},{"id":"ENSMUSP00000083752","abundance":0.744,"rank":12141,"name":"Trmo","annotation":"tRNA (adenine(37)-N6)-methyltransferase; S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA."},{"id":"ENSMUSP00000108824","abundance":0.744,"rank":12142,"name":"Armcx1","annotation":"Armadillo repeat-containing X-linked protein 1; Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with Miro1."},{"id":"ENSMUSP00000080582","abundance":0.743,"rank":12143,"name":"Ceacam5","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 5; Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells."},{"id":"ENSMUSP00000034960","abundance":0.743,"rank":12144,"name":"Dpp8","annotation":"Dipeptidyl peptidase 8; Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2."},{"id":"ENSMUSP00000130950","abundance":0.743,"rank":12145,"name":"Nol4","annotation":"Nucleolar protein 4."},{"id":"ENSMUSP00000037079","abundance":0.743,"rank":12146,"name":"Lmo1","annotation":"Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors."},{"id":"ENSMUSP00000067085","abundance":0.743,"rank":12147,"name":"Irs4","annotation":"Insulin receptor substrate 4; Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin- stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kin [...] "},{"id":"ENSMUSP00000118033","abundance":0.742,"rank":12148,"name":"Fam47e","annotation":"Family with sequence similarity 47, member E."},{"id":"ENSMUSP00000101828","abundance":0.742,"rank":12149,"name":"Gbp3","annotation":"Guanylate-binding protein 4; Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation."},{"id":"ENSMUSP00000032568","abundance":0.742,"rank":12150,"name":"Dmpk","annotation":"Myotonin-protein kinase; Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeo [...] "},{"id":"ENSMUSP00000048719","abundance":0.742,"rank":12151,"name":"Rims2","annotation":"Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (By similarity)."},{"id":"ENSMUSP00000031122","abundance":0.742,"rank":12152,"name":"Gabrb1","annotation":"Gamma-aminobutyric acid receptor subunit beta-1; Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel."},{"id":"ENSMUSP00000060769","abundance":0.742,"rank":12153,"name":"Crb1","annotation":"Protein crumbs homolog 1; Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion. Isoform 3 could play a role in epidermal tissue morphogenesis. May function in cell attachment for stratified epithelial organization; Belongs to the Crumbs protein family."},{"id":"ENSMUSP00000113651","abundance":0.742,"rank":12154,"name":"4930432K21Rik","annotation":"Uncharacterized protein C19orf57 homolog."},{"id":"ENSMUSP00000045650","abundance":0.742,"rank":12155,"name":"Tm7sf3","annotation":"Transmembrane 7 superfamily member 3; Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR)."},{"id":"ENSMUSP00000000449","abundance":0.741,"rank":12156,"name":"Mkrn2","annotation":"Probable E3 ubiquitin-protein ligase makorin-2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins."},{"id":"ENSMUSP00000100476","abundance":0.741,"rank":12157,"name":"Olfr585","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000074381","abundance":0.741,"rank":12158,"name":"Tlr12","annotation":"Toll-like receptor 12; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in preventing infection of internal organs of the urogenital system."},{"id":"ENSMUSP00000032719","abundance":0.741,"rank":12159,"name":"Nav3","annotation":"Neuron navigator 3; May regulate IL2 production by T-cells. May be involved in neuron regeneration."},{"id":"ENSMUSP00000029311","abundance":0.741,"rank":12160,"name":"Trpc4","annotation":"Short transient receptor potential channel 4; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Has also been shown to be calcium- selective (By similarity). May also be activated by intracellular calcium store depletion. Trpc4 deficient mice lack a store-operated calcium entry in endothelial cells."},{"id":"ENSMUSP00000021527","abundance":0.741,"rank":12161,"name":"Prkch","annotation":"Protein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] "},{"id":"ENSMUSP00000104417","abundance":0.74,"rank":12162,"name":"Zfp512b","annotation":"Zinc finger protein 512B."},{"id":"ENSMUSP00000041557","abundance":0.74,"rank":12163,"name":"Slc7a5","annotation":"Large neutral amino acids transporter small subunit 1; The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. Functions as an amino acid exchanger (By similarity). May play a role in the transport of L-DOPA across the blood-brain barrier (Probable). May act as the major transporter of tyrosine in fibroblasts (By similarity). May mediate blood-to-retina L-leucine transport across the inner blood- retinal barrier (By sim [...] "},{"id":"ENSMUSP00000043733","abundance":0.74,"rank":12164,"name":"Taf2","annotation":"Transcription initiation factor TFIID subunit 2; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter (By similarity)."},{"id":"ENSMUSP00000026156","abundance":0.739,"rank":12165,"name":"Rfng","annotation":"Beta-1,3-N-acetylglucosaminyltransferase radical fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis (By similarity)."},{"id":"ENSMUSP00000102647","abundance":0.739,"rank":12166,"name":"Arhgef17","annotation":"Rho guanine nucleotide exchange factor 17; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases."},{"id":"ENSMUSP00000021368","abundance":0.739,"rank":12167,"name":"Nemf","annotation":"Nuclear export mediator factor Nemf; Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. NEMF is responsible for selective recognition of stalled 60S subunits by recognizing an exposed, nascent chain-conjugated tRNA moiety. Nemf is important for the stable association of Ltn1 to the complex. May indirectly play a role in nuclear export."},{"id":"ENSMUSP00000125324","abundance":0.739,"rank":12168,"name":"4933417A18Rik","annotation":"Uncharacterized protein C6orf201 homolog."},{"id":"ENSMUSP00000042702","abundance":0.739,"rank":12169,"name":"Rpgrip1l","annotation":"Protein fantom; Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (By similarity). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis. Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of dis [...] "},{"id":"ENSMUSP00000092600","abundance":0.738,"rank":12170,"name":"Gm13271","annotation":"Predicted gene 13271."},{"id":"ENSMUSP00000100053","abundance":0.738,"rank":12171,"name":"Dclre1c","annotation":"Protein artemis; Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and  [...] "},{"id":"ENSMUSP00000109090","abundance":0.738,"rank":12172,"name":"Nr2c2","annotation":"Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA- mediated transactivation (By similarity). Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex t [...] "},{"id":"ENSMUSP00000090987","abundance":0.738,"rank":12173,"name":"Spred2","annotation":"Sprouty-related, EVH1 domain-containing protein 2; Negatively regulates Ras signaling pathways and downstream activation of MAP kinases."},{"id":"ENSMUSP00000106302","abundance":0.738,"rank":12174,"name":"Lcmt2","annotation":"tRNA wybutosine-synthesizing protein 4; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family."},{"id":"ENSMUSP00000133122","abundance":0.738,"rank":12175,"name":"P2ry10b","annotation":"Purinergic receptor P2Y, G-protein-coupled 10B."},{"id":"ENSMUSP00000067752","abundance":0.738,"rank":12176,"name":"Hook2","annotation":"Protein Hook homolog 2; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones."},{"id":"ENSMUSP00000150378","abundance":0.738,"rank":12177,"name":"Olfr867","annotation":"Olfactory receptor 867; Possible olfactory or taste receptor. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000037456","abundance":0.737,"rank":12178,"name":"BC034090","annotation":"cDNA sequence BC034090."},{"id":"ENSMUSP00000024884","abundance":0.737,"rank":12179,"name":"Eif2ak2","annotation":"Interferon-induced, double-stranded RNA-activated protein kinase; IFN-induced dsRNA-dependent serine/threonine-protein kinase which plays a key role in the innate immune response to viral infection and is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation. Exerts its antiviral activity on a wide range of DNA and RNA viruses including west nile virus (WNV), sindbis virus (SV), foot-and-mouth virus (FMDV), semliki Forest virus (SFV) and lymphocytic choriomeningitis virus (LCMV). Inhibits viral replication via phosphorylation of the a [...] "},{"id":"ENSMUSP00000087633","abundance":0.737,"rank":12180,"name":"Adh7","annotation":"All-trans-retinol dehydrogenase [NAD(+)] ADH7; Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency [...] "},{"id":"ENSMUSP00000005064","abundance":0.736,"rank":12181,"name":"Pias4","annotation":"E3 SUMO-protein ligase PIAS4; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylati [...] "},{"id":"ENSMUSP00000004494","abundance":0.736,"rank":12182,"name":"Sin3b","annotation":"Paired amphipathic helix protein Sin3b; Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression."},{"id":"ENSMUSP00000039689","abundance":0.736,"rank":12183,"name":"Dzip1","annotation":"Zinc finger protein DZIP1; May participate in spermatogenesis via its interaction with DAZL. Has a role in primary cilium formation. Belongs to the DZIP C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000134031","abundance":0.735,"rank":12184,"name":"Znhit2","annotation":"Zinc finger HIT domain-containing protein 2; May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (By similarity). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (By similarity). May play a role in regulating the composition of the U5 snRNP complex (By similarity)."},{"id":"ENSMUSP00000043142","abundance":0.735,"rank":12185,"name":"Raver2","annotation":"Ribonucleoprotein PTB-binding 2; May bind single-stranded nucleic acids."},{"id":"ENSMUSP00000017868","abundance":0.735,"rank":12186,"name":"Etv4","annotation":"ETS translocation variant 4; Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'. May play a regulatory role during embryogenesis; Belongs to the ETS family."},{"id":"ENSMUSP00000006914","abundance":0.735,"rank":12187,"name":"B4galnt1","annotation":"Beta-1,4 N-acetylgalactosaminyltransferase 1; Involved in the biosynthesis of gangliosides GM2, GD2 and GA2; Belongs to the glycosyltransferase 2 family."},{"id":"ENSMUSP00000031810","abundance":0.735,"rank":12188,"name":"Cep41","annotation":"Centrosomal protein of 41 kDa; Required during ciliogenesis for tubulin glutamylation in cilium. Probably acts by participating in the transport of TTLL6, a tubulin polyglutamylase, between the basal body and the cilium."},{"id":"ENSMUSP00000032074","abundance":0.734,"rank":12189,"name":"Nat8f5","annotation":"Probable N-acetyltransferase CML5; May play a role in regulation of gastrulation. Belongs to the camello family."},{"id":"ENSMUSP00000025350","abundance":0.734,"rank":12190,"name":"Dcp2","annotation":"m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (By similarity). Plays a role in replication-dependent histone mRNA degradation (By similarity). Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety."},{"id":"ENSMUSP00000028815","abundance":0.734,"rank":12191,"name":"Slc23a2","annotation":"Solute carrier family 23 member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity)."},{"id":"ENSMUSP00000059435","abundance":0.733,"rank":12192,"name":"Gm527","annotation":"Uncharacterized protein C14orf28 homolog."},{"id":"ENSMUSP00000048358","abundance":0.733,"rank":12193,"name":"Ltb4r2","annotation":"Leukotriene B4 receptor 2; Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity)."},{"id":"ENSMUSP00000079222","abundance":0.733,"rank":12194,"name":"Zfp551","annotation":"Zinc finger protein 551; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000139523","abundance":0.733,"rank":12195,"name":"Gm29276","annotation":"Predicted gene 29276."},{"id":"ENSMUSP00000141173","abundance":0.733,"rank":12196,"name":"Gm21996","annotation":"Predicted gene 21996."},{"id":"ENSMUSP00000086711","abundance":0.733,"rank":12197,"name":"Olfr658","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000108692","abundance":0.732,"rank":12198,"name":"Slc25a53","annotation":"Solute carrier family 25, member 53; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000071641","abundance":0.732,"rank":12199,"name":"Olfr39","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000031426","abundance":0.732,"rank":12200,"name":"Ift81","annotation":"Intraflagellar transport protein 81 homolog; Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. [Isoform CDV-1R]: May play a role in development of the testis and spermatogenesis."},{"id":"ENSMUSP00000095574","abundance":0.732,"rank":12201,"name":"Alg6","annotation":"Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase; Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol (By similarity); Belongs to the ALG6/ALG8 glucosyltransferase family."},{"id":"ENSMUSP00000037088","abundance":0.732,"rank":12202,"name":"H2-DMa","annotation":"Class II histocompatibility antigen, M alpha chain; Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides."},{"id":"ENSMUSP00000042151","abundance":0.731,"rank":12203,"name":"Rundc1","annotation":"RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity."},{"id":"ENSMUSP00000052055","abundance":0.731,"rank":12204,"name":"Lrrc8e","annotation":"Volume-regulated anion channel subunit LRRC8E; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Mediates efflux of amino acids, such as aspartate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depen [...] "},{"id":"ENSMUSP00000116747","abundance":0.731,"rank":12205,"name":"Slc4a3","annotation":"Anion exchange protein 3; Plasma membrane anion exchange protein; Belongs to the anion exchanger (TC 2.A.31) family."},{"id":"ENSMUSP00000031982","abundance":0.731,"rank":12206,"name":"Hpgds","annotation":"Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity."},{"id":"ENSMUSP00000016344","abundance":0.731,"rank":12207,"name":"Syt14","annotation":"Synaptotagmin-14; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent; Belongs to the synaptotagmin family."},{"id":"ENSMUSP00000110006","abundance":0.731,"rank":12208,"name":"Aox2","annotation":"Aldehyde oxidase 2; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. Cannot use hypoxanthine as substrate."},{"id":"ENSMUSP00000023441","abundance":0.73,"rank":12209,"name":"P2rx6","annotation":"P2X purinoceptor 6; Receptor for ATP that acts as a ligand-gated ion channel."},{"id":"ENSMUSP00000120649","abundance":0.73,"rank":12210,"name":"Gpatch8","annotation":"G patch domain-containing protein 8."},{"id":"ENSMUSP00000029919","abundance":0.73,"rank":12211,"name":"Clca1","annotation":"Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. Belongs to the CLCR family."},{"id":"ENSMUSP00000036326","abundance":0.729,"rank":12212,"name":"Crlf2","annotation":"Cytokine receptor-like factor 2; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system."},{"id":"ENSMUSP00000073504","abundance":0.729,"rank":12213,"name":"Pou6f1","annotation":"POU domain, class 6, transcription factor 1; Transcription factor that binds preferentially to a variant of the octamer motif (5'-ATGATAAT-3')."},{"id":"ENSMUSP00000025290","abundance":0.729,"rank":12214,"name":"Impact","annotation":"Protein IMPACT; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 ac [...] "},{"id":"ENSMUSP00000000369","abundance":0.729,"rank":12215,"name":"Rem1","annotation":"GTP-binding protein REM 1; Promotes endothelial cell sprouting and actin cytoskeletal reorganization (By similarity). May be involved in angiogenesis. May function in Ca(2+) signaling; Belongs to the small GTPase superfamily. RGK family."},{"id":"ENSMUSP00000029123","abundance":0.729,"rank":12216,"name":"a","annotation":"Agouti-signaling protein; Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). Causes hair follicle melanocytes to synthesize phaeomelanin instead of black or brown pigment eumelanin and produces hairs with a subapical yellow band on an otherwise black or brown background when expressed during the mid-portion of hair growth."},{"id":"ENSMUSP00000092380","abundance":0.728,"rank":12217,"name":"Slc34a2","annotation":"Sodium-dependent phosphate transport protein 2B; May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli; Belongs to the SLC34A transporter family."},{"id":"ENSMUSP00000038473","abundance":0.728,"rank":12218,"name":"Ccr8","annotation":"C-C chemokine receptor type 8; Receptor for the CCL1/SCY1/TCA-3 chemokine."},{"id":"ENSMUSP00000140214","abundance":0.728,"rank":12219,"name":"Scgb1b11","annotation":"Secretoglobin, family 1B, member 11."},{"id":"ENSMUSP00000140824","abundance":0.728,"rank":12220,"name":"Scgb1b18","annotation":"Secretoglobin, family 1B, member 18."},{"id":"ENSMUSP00000088118","abundance":0.728,"rank":12221,"name":"Kcna10","annotation":"Potassium voltage-gated channel subfamily A member 10; Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP; Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily."},{"id":"ENSMUSP00000050854","abundance":0.728,"rank":12222,"name":"Zfp367","annotation":"Zinc finger protein 367; Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes (By similarity)."},{"id":"ENSMUSP00000068551","abundance":0.728,"rank":12223,"name":"Tmem120b","annotation":"Transmembrane protein 120B; Necessary for efficient adipogenesis. Belongs to the TMEM120 family."},{"id":"ENSMUSP00000101094","abundance":0.728,"rank":12224,"name":"Col13a1","annotation":"Collagen alpha-1(XIII) chain; Involved in cell-matrix and cell-cell adhesion interactions that are required for normal development. May participate in the linkage between muscle fiber and basement membrane. May play a role in endochondral ossification of bone and branching morphogenesis of lung. Binds heparin. At neuromuscular junctions, may play a role in acetylcholine receptor clustering."},{"id":"ENSMUSP00000042177","abundance":0.727,"rank":12225,"name":"Kank1","annotation":"KN motif and ankyrin repeat domains 1."},{"id":"ENSMUSP00000133885","abundance":0.727,"rank":12226,"name":"Fam71e2","annotation":"Family with sequence similarity 71, member E2."},{"id":"ENSMUSP00000045639","abundance":0.727,"rank":12227,"name":"Klf9","annotation":"Krueppel-like factor 9; Transcription factor that binds to GC box promoter elements. Selectively activates mRNA synthesis from genes containing tandem repeats of GC boxes but represses genes with a single GC box. Acts as an epidermal circadian transcription factor regulating keratinocyte proliferation; Belongs to the Sp1 C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000125303","abundance":0.726,"rank":12228,"name":"Ano2","annotation":"Anoctamin-2; Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor- sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina. Belongs to the anoctamin family."},{"id":"ENSMUSP00000086112","abundance":0.726,"rank":12229,"name":"Olfm4","annotation":"Olfactomedin-4; May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin (By similarity)."},{"id":"ENSMUSP00000066005","abundance":0.726,"rank":12230,"name":"Cdh24","annotation":"Cadherin-24; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Cadherin-24 mediate strong cell-cell adhesion (By similarity)."},{"id":"ENSMUSP00000130987","abundance":0.726,"rank":12231,"name":"Gm9573","annotation":"Predicted gene 9573."},{"id":"ENSMUSP00000154456","abundance":0.726,"rank":12232,"name":"Vmn1r49","annotation":"Vomeronasal type-1 receptor 49; Putative pheromone receptor implicated in the regulation of social and reproductive behavior; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000055246","abundance":0.726,"rank":12233,"name":"Gjd3","annotation":"Gap junction delta-3 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell."},{"id":"ENSMUSP00000023362","abundance":0.726,"rank":12234,"name":"Ntan1","annotation":"Protein N-terminal asparagine amidohydrolase; N-terminal asparagine deamidase that mediates deamidation of N-terminal asparagine residues to aspartate. Required for the ubiquitin-dependent turnover of intracellular proteins that initiate with Met-Asn. These proteins are acetylated on the retained initiator methionine and can subsequently be modified by the removal of N-acetyl methionine by acylaminoacid hydrolase (AAH). Conversion of the resulting N-terminal asparagine to aspartate by NTAN1/PNAD renders the protein susceptible to arginylation, polyubiquitination and degradation as spec [...] "},{"id":"ENSMUSP00000140670","abundance":0.725,"rank":12235,"name":"Usp37","annotation":"Ubiquitin carboxyl-terminal hydrolase 37; Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 an [...] "},{"id":"ENSMUSP00000095496","abundance":0.725,"rank":12236,"name":"5730409E04Rik","annotation":"UPF0500 protein C1orf216 homolog; Belongs to the UPF0500 family."},{"id":"ENSMUSP00000017751","abundance":0.724,"rank":12237,"name":"Tns4","annotation":"Tensin-4; May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton May promote apoptosis, via its cleavage by caspase-3. Cytoplasm, cytoskeleton."},{"id":"ENSMUSP00000059708","abundance":0.724,"rank":12238,"name":"Ppp1r17","annotation":"Protein phosphatase 1 regulatory subunit 17; Inhibits phosphatase activities of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) complexes."},{"id":"ENSMUSP00000093406","abundance":0.724,"rank":12239,"name":"Akap6","annotation":"A kinase (PRKA) anchor protein 6."},{"id":"ENSMUSP00000110238","abundance":0.724,"rank":12240,"name":"Zfp513","annotation":"Zinc finger protein 513; Transcriptional regulator that plays a role in retinal development and maintenance."},{"id":"ENSMUSP00000112252","abundance":0.723,"rank":12241,"name":"Tmprss11f","annotation":"Transmembrane protease serine 11F; Probable serine protease; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000119850","abundance":0.723,"rank":12242,"name":"Gm45902","annotation":"Predicted gene 45902."},{"id":"ENSMUSP00000006742","abundance":0.723,"rank":12243,"name":"Atp7b","annotation":"Copper-transporting ATPase 2; Copper ion transmembrane transporter involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile."},{"id":"ENSMUSP00000056026","abundance":0.722,"rank":12244,"name":"Thtpa","annotation":"Thiamine-triphosphatase; Hydrolase highly specific for thiamine triphosphate (ThTP). Belongs to the ThTPase family."},{"id":"ENSMUSP00000117710","abundance":0.722,"rank":12245,"name":"Wdr17","annotation":"WD repeat domain 17."},{"id":"ENSMUSP00000066449","abundance":0.721,"rank":12246,"name":"Gpr21","annotation":"Probable G-protein coupled receptor 21; Orphan receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000061913","abundance":0.721,"rank":12247,"name":"Lsm10","annotation":"U7 snRNA-associated Sm-like protein LSm10; Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing (By similarity). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (By similarity). Required for cell cycle progression from G1 to S phases (By similarity). Binds specifically to U7 snRNA (By similarity). Binds specifically to U7 snRNA (By similarity). Binds to the downstream cleavage product (DCP) of histone pre-mRNA; Belongs to the snRNP Sm proteins family."},{"id":"ENSMUSP00000153718","abundance":0.721,"rank":12248,"name":"Atg14","annotation":"Beclin 1-associated autophagy-related key regulator; Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (By similarity). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine. Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (By similarity). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (By similarity). Stimulates the phosphorylation of BECN1, but suppresses the phosph [...] "},{"id":"ENSMUSP00000017851","abundance":0.72,"rank":12249,"name":"Serinc3","annotation":"Serine incorporator 3; Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm; Belongs to the TDE1 family."},{"id":"ENSMUSP00000078343","abundance":0.72,"rank":12250,"name":"Adam1b","annotation":"Disintegrin and metalloproteinase domain-containing protein 1b; May play a role in spermatogenesis and sperm maturation."},{"id":"ENSMUSP00000103431","abundance":0.72,"rank":12251,"name":"Tead2","annotation":"Transcriptional enhancer factor TEF-4; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] "},{"id":"ENSMUSP00000127571","abundance":0.72,"rank":12252,"name":"Cdca2","annotation":"Cell division cycle-associated protein 2; Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates (By similarity)."},{"id":"ENSMUSP00000056485","abundance":0.72,"rank":12253,"name":"Tcf25","annotation":"Transcription factor 25; May play a role in cell death control. Acts as a transcriptional repressor. Has been shown to repress transcription of SRF in vitro and so may play a role in heart development (By similarity); Belongs to the TCF25 family."},{"id":"ENSMUSP00000034197","abundance":0.72,"rank":12254,"name":"St3gal2","annotation":"CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2; Responsible for the synthesis of the sequence NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides and glycolipids. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values."},{"id":"ENSMUSP00000100028","abundance":0.72,"rank":12255,"name":"Dnaic1","annotation":"Dynein intermediate chain 1, axonemal; Part of the dynein complex of respiratory cilia."},{"id":"ENSMUSP00000061401","abundance":0.719,"rank":12256,"name":"Cdcp2","annotation":"CUB domain-containing protein 2."},{"id":"ENSMUSP00000045613","abundance":0.719,"rank":12257,"name":"Slc36a2","annotation":"Proton-coupled amino acid transporter 2; Involved in a pH-dependent electrogenic neuronal transport and sequestration of small amino acids amino acids such as glycine, alanine and proline. Inhibited by sarcosine."},{"id":"ENSMUSP00000049057","abundance":0.719,"rank":12258,"name":"Trim37","annotation":"E3 ubiquitin-protein ligase TRIM37; E3 ubiquitin-protein ligase required to prevent centriole reduplication (By similarity). Probably acts by ubiquitinating positive regulators of centriole reduplication (By similarity). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes."},{"id":"ENSMUSP00000031853","abundance":0.719,"rank":12259,"name":"Npvf","annotation":"Pro-FMRFamide-related neuropeptide VF; Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP. Neuropeptide NPVF blocks morphine-induced analgesia (By similarity)."},{"id":"ENSMUSP00000111042","abundance":0.719,"rank":12260,"name":"Jade3","annotation":"Protein Jade-3; Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Belongs to the JADE family."},{"id":"ENSMUSP00000102813","abundance":0.719,"rank":12261,"name":"Bnipl","annotation":"Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein; May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death."},{"id":"ENSMUSP00000097015","abundance":0.718,"rank":12262,"name":"Gm10770","annotation":"Predicted gene 10770."},{"id":"ENSMUSP00000019224","abundance":0.718,"rank":12263,"name":"Mfsd3","annotation":"Major facilitator superfamily domain-containing protein 3."},{"id":"ENSMUSP00000112063","abundance":0.717,"rank":12264,"name":"Ctc1","annotation":"CST complex subunit CTC1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. The CST comp [...] "},{"id":"ENSMUSP00000141443","abundance":0.717,"rank":12265,"name":"Ddr2","annotation":"Discoidin domain-containing receptor 2; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up- regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migra [...] "},{"id":"ENSMUSP00000100987","abundance":0.717,"rank":12266,"name":"Mex3d","annotation":"RNA-binding protein MEX3D; RNA binding protein, may be involved in post-transcriptional regulatory mechanisms."},{"id":"ENSMUSP00000026093","abundance":0.716,"rank":12267,"name":"Btbd1","annotation":"BTB/POZ domain-containing protein 1; Probable substrate-specific adapter of an E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Seems to regulate expression levels and/or subnuclear distribution of TOP1, via an unknown mechanism. May play a role in mesenchymal differentiation where it promotes myogenic differentiation and suppresses adipogenesis."},{"id":"ENSMUSP00000114323","abundance":0.716,"rank":12268,"name":"Rit2","annotation":"GTP-binding protein Rit2; Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. Belongs to the small GTPase superfamily. Ras family."},{"id":"ENSMUSP00000151862","abundance":0.716,"rank":12269,"name":"Olfr702","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000058502","abundance":0.716,"rank":12270,"name":"Ubiad1","annotation":"UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzym [...] "},{"id":"ENSMUSP00000045437","abundance":0.716,"rank":12271,"name":"Acp7","annotation":"Acid phosphatase type 7; Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family."},{"id":"ENSMUSP00000092392","abundance":0.716,"rank":12272,"name":"Psg26","annotation":"Pregnancy-specific glycoprotein 26."},{"id":"ENSMUSP00000031378","abundance":0.715,"rank":12273,"name":"Stx2","annotation":"Syntaxin-2; Essential for epithelial morphogenesis. May mediate Ca(2+)- regulation of exocytosis acrosomal reaction in sperm."},{"id":"ENSMUSP00000032781","abundance":0.715,"rank":12274,"name":"Nox4","annotation":"NADPH oxidase 4; Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB."},{"id":"ENSMUSP00000047763","abundance":0.715,"rank":12275,"name":"Neb","annotation":"Nebulin."},{"id":"ENSMUSP00000045304","abundance":0.715,"rank":12276,"name":"Prkx","annotation":"cAMP-dependent protein kinase catalytic subunit PRKX; Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular- like stru [...] "},{"id":"ENSMUSP00000059154","abundance":0.714,"rank":12277,"name":"Mplkip","annotation":"M-phase-specific PLK1-interacting protein; May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis."},{"id":"ENSMUSP00000101307","abundance":0.714,"rank":12278,"name":"Rere","annotation":"Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival."},{"id":"ENSMUSP00000063542","abundance":0.714,"rank":12279,"name":"Opn5","annotation":"Opsin-5; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily."},{"id":"ENSMUSP00000101783","abundance":0.714,"rank":12280,"name":"Notum","annotation":"Palmitoleoyl-protein carboxylesterase NOTUM; Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors."},{"id":"ENSMUSP00000080069","abundance":0.714,"rank":12281,"name":"Poteg","annotation":"POTE ankyrin domain family, member G."},{"id":"ENSMUSP00000038633","abundance":0.714,"rank":12282,"name":"Galnt9","annotation":"Polypeptide N-acetylgalactosaminyltransferase."},{"id":"ENSMUSP00000075164","abundance":0.713,"rank":12283,"name":"Olfr212","annotation":"Olfactory receptor Olfr212."},{"id":"ENSMUSP00000128881","abundance":0.713,"rank":12284,"name":"Whamm","annotation":"WASP homolog-associated protein with actin, membranes and microtubules; Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Involved as a regulator of Golgi positioning and morphology. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin- nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevente [...] "},{"id":"ENSMUSP00000029632","abundance":0.713,"rank":12285,"name":"Lrat","annotation":"Lecithin retinol acyltransferase; Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (By similarity). Retinyl esters are storage forms of vitamin A (By similarity). LRAT plays a critical role in vision (By similarity). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis- retinaldehyde which is the chrom [...] "},{"id":"ENSMUSP00000041113","abundance":0.712,"rank":12286,"name":"Txndc11","annotation":"Thioredoxin domain-containing protein 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (By similarity)."},{"id":"ENSMUSP00000106358","abundance":0.712,"rank":12287,"name":"Nek3","annotation":"Serine/threonine-protein kinase Nek3; Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2."},{"id":"ENSMUSP00000046465","abundance":0.712,"rank":12288,"name":"Leng8","annotation":"Leukocyte receptor cluster member 8 homolog."},{"id":"ENSMUSP00000060247","abundance":0.712,"rank":12289,"name":"B3gnt2","annotation":"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Probably constitutes the main polylactosamine synthase ; Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000069422","abundance":0.712,"rank":12290,"name":"Nt5c1a","annotation":"Cytosolic 5'-nucleotidase 1A; Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (By similarity)."},{"id":"ENSMUSP00000131462","abundance":0.711,"rank":12291,"name":"Cpvl","annotation":"Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family."},{"id":"ENSMUSP00000034396","abundance":0.711,"rank":12292,"name":"Mtmr2","annotation":"Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards pho sphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate. Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5- trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily."},{"id":"ENSMUSP00000059026","abundance":0.711,"rank":12293,"name":"Six1","annotation":"Homeobox protein SIX1; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter. Regulates the expression of nume [...] "},{"id":"ENSMUSP00000132104","abundance":0.71,"rank":12294,"name":"Gm42421","annotation":"Predicted gene, 42421."},{"id":"ENSMUSP00000105140","abundance":0.71,"rank":12295,"name":"Bcl11a","annotation":"B-cell lymphoma/leukemia 11A; May play a role in hematopoiesis. Essential factor in lymphopoiesis, required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1."},{"id":"ENSMUSP00000056853","abundance":0.71,"rank":12296,"name":"Olfr1326-ps1","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000034206","abundance":0.71,"rank":12297,"name":"Bbs2","annotation":"Bardet-Biedl syndrome 2 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the gua [...] "},{"id":"ENSMUSP00000025752","abundance":0.71,"rank":12298,"name":"Pola2","annotation":"DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (By similarity). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymer [...] "},{"id":"ENSMUSP00000149440","abundance":0.709,"rank":12299,"name":"Olfr513","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000022727","abundance":0.709,"rank":12300,"name":"Tgds","annotation":"dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily."},{"id":"ENSMUSP00000137353","abundance":0.708,"rank":12301,"name":"Ccl19-2","annotation":"Predicted 2023."},{"id":"ENSMUSP00000100022","abundance":0.708,"rank":12302,"name":"Ccl19","annotation":"C-C motif chemokine 19; Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4."},{"id":"ENSMUSP00000141121","abundance":0.708,"rank":12303,"name":"Cys1","annotation":"Cystin-1."},{"id":"ENSMUSP00000095665","abundance":0.708,"rank":12304,"name":"Musk","annotation":"Muscle, skeletal receptor tyrosine-protein kinase; Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskel [...] "},{"id":"ENSMUSP00000035662","abundance":0.708,"rank":12305,"name":"Arap3","annotation":"Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase- activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts preferentially on ARF5 and on RHOA."},{"id":"ENSMUSP00000016125","abundance":0.708,"rank":12306,"name":"Stk32c","annotation":"Serine/threonine-protein kinase 32C."},{"id":"ENSMUSP00000030198","abundance":0.708,"rank":12307,"name":"Reck","annotation":"Reversion-inducing cysteine-rich protein with Kazal motifs; Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Acts as a Wnt7- specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (By similarity). ADGRA2 is then required to deliver RECK-bound [...] "},{"id":"ENSMUSP00000149191","abundance":0.708,"rank":12308,"name":"Olfr1448","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000047825","abundance":0.708,"rank":12309,"name":"Wrap53","annotation":"Telomerase Cajal body protein 1; RNA chaperone that plays a key role in telomere maintenance and RNA localization to Cajal bodies. Specifically recognizes and binds the Cajal body box (CAB box) present in both small Cajal body RNAs (scaRNAs) and telomerase RNA template component (TERC). Essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex essential for the replication of chromosome termini that elongates telomeres in most eukaryotes (By similarity). In the telomerase holoenzyme complex, required to stimulate the catalytic activity of the complex. Acts b [...] "},{"id":"ENSMUSP00000031734","abundance":0.708,"rank":12310,"name":"Lrch4","annotation":"Leucine-rich repeat and calponin homology domain-containing protein 4."},{"id":"ENSMUSP00000006178","abundance":0.708,"rank":12311,"name":"Kptn","annotation":"KICSTOR complex protein kaptin; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose."},{"id":"ENSMUSP00000090730","abundance":0.707,"rank":12312,"name":"Gas8","annotation":"Dynein regulatory complex subunit 4; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh [...] "},{"id":"ENSMUSP00000027768","abundance":0.707,"rank":12313,"name":"Ahctf1","annotation":"Protein ELYS; Required for the assembly of a functional nuclear pore complex (NPC) on the surface of chromosomes as nuclei form at the end of mitosis. May initiate NPC assembly by binding to chromatin and recruiting the Nup107-160 subcomplex of the NPC. Also required for the localization of the Nup107-160 subcomplex of the NPC to the kinetochore during mitosis and for the completion of cytokinesis (By similarity). Has also been proposed to function as a transcription factor which may play a specific role in hematopoietic tissues."},{"id":"ENSMUSP00000124043","abundance":0.707,"rank":12314,"name":"Ubn2","annotation":"Ubinuclein-2."},{"id":"ENSMUSP00000153232","abundance":0.707,"rank":12315,"name":"Gm49391","annotation":"Predicted gene, 49391."},{"id":"ENSMUSP00000022577","abundance":0.707,"rank":12316,"name":"Zc3h13","annotation":"Zinc finger CCCH domain-containing protein 13; Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR. Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation. In the WMM complex, anchors component of the MACOM subcomplex in the nucleus. Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B)."},{"id":"ENSMUSP00000058348","abundance":0.707,"rank":12317,"name":"Gal3st1","annotation":"Galactosylceramide sulfotransferase; Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of HSO3-3- galactosylceramide (sulfatide), a major lipid component of the myelin sheath and of HSO3-3-monogalactosylalkylacylglycerol (seminolipid), present in spermatocytes. Also acts on lactosylceramide, galactosyl 1- alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro)."},{"id":"ENSMUSP00000060893","abundance":0.707,"rank":12318,"name":"Gpr149","annotation":"Probable G-protein coupled receptor 149; Orphan receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000051079","abundance":0.707,"rank":12319,"name":"Adgrg3","annotation":"Adhesion G protein-coupled receptor G3; Orphan receptor that regulates migration of lymphatic endothelial cells via the small GTPases RhoA and CDC42 (By similarity). Regulates B-cell development. Seems to signal through G-alpha(q)-proteins (By similarity); Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily."},{"id":"ENSMUSP00000064394","abundance":0.706,"rank":12320,"name":"Jak2","annotation":"Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] "},{"id":"ENSMUSP00000114495","abundance":0.706,"rank":12321,"name":"Akap5","annotation":"A-kinase anchor protein 5; May anchor the PKA kinase to cytoskeletal and/or organelle- associated proteins, targeting the signal carried by cAMP to specific intracellular effectors."},{"id":"ENSMUSP00000021729","abundance":0.706,"rank":12322,"name":"Gpr132","annotation":"Probable G-protein coupled receptor 132; May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensin [...] "},{"id":"ENSMUSP00000092344","abundance":0.706,"rank":12323,"name":"Ceacam20","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 20; Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response. Belongs to the immunoglobulin superfamily. CEA family."},{"id":"ENSMUSP00000099122","abundance":0.706,"rank":12324,"name":"Klf14","annotation":"Krueppel-like factor 14."},{"id":"ENSMUSP00000056196","abundance":0.706,"rank":12325,"name":"D630023F18Rik","annotation":"Uncharacterized protein C2orf80 homolog."},{"id":"ENSMUSP00000092305","abundance":0.706,"rank":12326,"name":"Grxcr1","annotation":"Glutaredoxin domain-containing cysteine-rich protein 1; May play a role in actin filament architecture in developing stereocilia of sensory cells; Belongs to the GRXCR1 family."},{"id":"ENSMUSP00000150381","abundance":0.705,"rank":12327,"name":"Olfr655","annotation":"Olfactory receptor 655."},{"id":"ENSMUSP00000030816","abundance":0.705,"rank":12328,"name":"Dffa","annotation":"DNA fragmentation factor subunit alpha; Inhibitor of the caspase-activated DNase (DFF40)."},{"id":"ENSMUSP00000105223","abundance":0.705,"rank":12329,"name":"Slc1a4","annotation":"Neutral amino acid transporter A; Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence (By similarity); Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A4 subfamily."},{"id":"ENSMUSP00000108717","abundance":0.705,"rank":12330,"name":"Iqca","annotation":"Dynein regulatory complex protein 11; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the AAA ATPase family. DRC11 subfamily."},{"id":"ENSMUSP00000113717","abundance":0.705,"rank":12331,"name":"Pcf11","annotation":"PCF11 cleavage and polyadenylation factor subunit."},{"id":"ENSMUSP00000034203","abundance":0.705,"rank":12332,"name":"Cog4","annotation":"Conserved oligomeric Golgi complex subunit 4; Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1."},{"id":"ENSMUSP00000029639","abundance":0.704,"rank":12333,"name":"Snx7","annotation":"Sorting nexin-7; May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family."},{"id":"ENSMUSP00000084577","abundance":0.704,"rank":12334,"name":"Ddhd1","annotation":"Phospholipase DDHD1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity (By similarity). Required for the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER) (By similarity). Belongs to the PA-PLA1 family."},{"id":"ENSMUSP00000113843","abundance":0.703,"rank":12335,"name":"S1pr5","annotation":"Sphingosine 1-phosphate receptor 5; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). S1P activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival. S1P activation on O4-positive pre-oligodendrocytes induces process retraction via a Rho kinase/collapsin response-mediated protein signaling p [...] "},{"id":"ENSMUSP00000033756","abundance":0.703,"rank":12336,"name":"Asb9","annotation":"Ankyrin repeat and SOCS box protein 9; Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A (By similarity); Belongs to the ankyrin SOCS box (ASB) family."},{"id":"ENSMUSP00000142903","abundance":0.703,"rank":12337,"name":"Med12l","annotation":"Mediator of RNA polymerase II transcription subunit 12-like protein; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By  [...] "},{"id":"ENSMUSP00000039598","abundance":0.703,"rank":12338,"name":"Fig4","annotation":"Polyphosphoinositide phosphatase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes."},{"id":"ENSMUSP00000081889","abundance":0.702,"rank":12339,"name":"Ncapg2","annotation":"Condensin-2 complex subunit G2; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. Is required for early embryonic development and is essential for viability and expansion of the inner cell mass (ICM) of the implanting blastocyst."},{"id":"ENSMUSP00000067305","abundance":0.702,"rank":12340,"name":"Acvr2a","annotation":"Activin receptor type-2A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily."},{"id":"ENSMUSP00000099782","abundance":0.702,"rank":12341,"name":"Slc5a9","annotation":"Sodium/glucose cotransporter 4; Involved in sodium-dependent transport of D-mannose, D- glucose and D-fructose; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family."},{"id":"ENSMUSP00000045827","abundance":0.702,"rank":12342,"name":"Spata7","annotation":"Spermatogenesis-associated protein 7 homolog; Involved in the maintenance of both rod and cone photoreceptor cells. Required for photoreceptor-specific localization of proximal connecting cilium (CC) proteins RPGR, AHI1, NPHP1, NPHP4, and RPGRIP1 at the distal CC, a photoreceptor-specific extension of the primary cilium transition zone. Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration."},{"id":"ENSMUSP00000046524","abundance":0.702,"rank":12343,"name":"Rftn1","annotation":"Raftlin; Involved in protein trafficking via association with clathrin and AP2 complex (By similarity). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3- positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. [...] "},{"id":"ENSMUSP00000079093","abundance":0.701,"rank":12344,"name":"Sirt7","annotation":"NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase and deglutarylase), depending on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac) (By similarity). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression (By similarity). H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone [...] "},{"id":"ENSMUSP00000148903","abundance":0.701,"rank":12345,"name":"Olfr979","annotation":"Olfactory receptor MOR223-1."},{"id":"ENSMUSP00000097314","abundance":0.701,"rank":12346,"name":"Gm4981","annotation":"Predicted gene, EG245263."},{"id":"ENSMUSP00000103560","abundance":0.701,"rank":12347,"name":"Fam71e1","annotation":"Protein FAM71E1."},{"id":"ENSMUSP00000048171","abundance":0.7,"rank":12348,"name":"Ror1","annotation":"Inactive tyrosine-protein kinase transmembrane receptor ROR1; Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (By similarity). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (By similarity). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells."},{"id":"ENSMUSP00000121775","abundance":0.7,"rank":12349,"name":"Slc45a4","annotation":"Solute carrier family 45 member 4; Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family."},{"id":"ENSMUSP00000058840","abundance":0.7,"rank":12350,"name":"Atp7a","annotation":"Copper-transporting ATPase 1; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily."},{"id":"ENSMUSP00000041636","abundance":0.7,"rank":12351,"name":"Calm4","annotation":"Calmodulin-4; Implicated in the early stage of ectopic ossification."},{"id":"ENSMUSP00000022386","abundance":0.7,"rank":12352,"name":"Samd4","annotation":"Protein Smaug homolog 1; Acts as a translational repressor of SRE-containing messengers; Belongs to the SMAUG family."},{"id":"ENSMUSP00000001254","abundance":0.7,"rank":12353,"name":"Slc26a3","annotation":"Chloride anion exchanger; Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family."},{"id":"ENSMUSP00000151090","abundance":0.7,"rank":12354,"name":"Olfr1018","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000039888","abundance":0.7,"rank":12355,"name":"Pcdhac2","annotation":"Protocadherin alpha subfamily C, 2."},{"id":"ENSMUSP00000140888","abundance":0.7,"rank":12356,"name":"Krtap15","annotation":"Keratin-associated protein 15-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the PMG family."},{"id":"ENSMUSP00000030709","abundance":0.699,"rank":12357,"name":"Smpdl3b","annotation":"Acid sphingomyelinase-like phosphodiesterase 3b; Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) ; Belongs to the acid sphingomyelinase family."},{"id":"ENSMUSP00000106303","abundance":0.699,"rank":12358,"name":"Tgm7","annotation":"Transglutaminase 7."},{"id":"ENSMUSP00000136731","abundance":0.699,"rank":12359,"name":"Scgb2b7","annotation":"Secretoglobin, family 2B, member 7."},{"id":"ENSMUSP00000026135","abundance":0.699,"rank":12360,"name":"Aspscr1","annotation":"Tether containing UBX domain for GLUT4; Enhances VCP methylation catalyzed by VCPKMT (By similarity). Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface."},{"id":"ENSMUSP00000027778","abundance":0.699,"rank":12361,"name":"Mixl1","annotation":"Homeobox protein MIXL1; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression."},{"id":"ENSMUSP00000154601","abundance":0.699,"rank":12362,"name":"Olfr286","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000159251","abundance":0.698,"rank":12363,"name":"ENSMUSP00000159251","annotation":"Novel protein."},{"id":"ENSMUSP00000044368","abundance":0.698,"rank":12364,"name":"Pygo1","annotation":"Pygopus homolog 1; Involved in signal transduction through the Wnt pathway."},{"id":"ENSMUSP00000035037","abundance":0.697,"rank":12365,"name":"Pik3cb","annotation":"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation  [...] "},{"id":"ENSMUSP00000045366","abundance":0.697,"rank":12366,"name":"Zmym6","annotation":"Zinc finger, MYM-type 6."},{"id":"ENSMUSP00000036477","abundance":0.697,"rank":12367,"name":"Strip2","annotation":"Striatin-interacting proteins 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity); Belongs to the STRIP family."},{"id":"ENSMUSP00000078503","abundance":0.697,"rank":12368,"name":"Fbxw20","annotation":"F-box and WD-40 domain protein 12."},{"id":"ENSMUSP00000050586","abundance":0.697,"rank":12369,"name":"Kndc1","annotation":"Kinase non-catalytic C-lobe domain-containing protein 1; RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2. May be involved in cellular senescence (By similarity)."},{"id":"ENSMUSP00000082318","abundance":0.697,"rank":12370,"name":"Trpm1","annotation":"Transient receptor potential cation channel subfamily M member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel; Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily."},{"id":"ENSMUSP00000058484","abundance":0.696,"rank":12371,"name":"Ccdc125","annotation":"Coiled-coil domain-containing protein 125; May be involved in the regulation of cell migration."},{"id":"ENSMUSP00000078632","abundance":0.696,"rank":12372,"name":"Gpatch1","annotation":"G patch domain-containing protein 1; Belongs to the GPATCH1 family."},{"id":"ENSMUSP00000046044","abundance":0.696,"rank":12373,"name":"Plekhh3","annotation":"Pleckstrin homology domain-containing family H member 3."},{"id":"ENSMUSP00000059056","abundance":0.696,"rank":12374,"name":"Spo11","annotation":"Meiotic recombination protein SPO11; [Isoform 1]: Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2."},{"id":"ENSMUSP00000024858","abundance":0.695,"rank":12375,"name":"Galnt14","annotation":"Polypeptide N-acetylgalactosaminyltransferase 14; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney (By similarity)."},{"id":"ENSMUSP00000034430","abundance":0.695,"rank":12376,"name":"Chst5","annotation":"Carbohydrate sulfotransferase 5; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues of keratan. Mediates sulfation of keratan in cornea. Keratan sulfate plays a central role in maintaining corneal transparency. Acts on the non- reducing terminal GlcNAc of short and long carbohydrate substrates that have poly-N-acetyllactosamine structures. May also have activity toward O-linked sugars of mucin-type acceptors; Belongs to the sulfotransferase 1 fami [...] "},{"id":"ENSMUSP00000042569","abundance":0.695,"rank":12377,"name":"Rnf113a1","annotation":"Ring finger protein 113A1."},{"id":"ENSMUSP00000038833","abundance":0.695,"rank":12378,"name":"Ripk2","annotation":"Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Once recruited, autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequ [...] "},{"id":"ENSMUSP00000127199","abundance":0.695,"rank":12379,"name":"Rem2","annotation":"GTP-binding protein REM 2; Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis."},{"id":"ENSMUSP00000059038","abundance":0.695,"rank":12380,"name":"Myorg","annotation":"Myogenesis-regulating glycosidase; Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2."},{"id":"ENSMUSP00000057910","abundance":0.694,"rank":12381,"name":"Tas2r143","annotation":"Taste receptor type 2 member 143; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000103916","abundance":0.694,"rank":12382,"name":"Fbxo27","annotation":"F-box only protein 27; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind complex-type oligosaccharides."},{"id":"ENSMUSP00000142680","abundance":0.694,"rank":12383,"name":"Stard3nl","annotation":"STARD3 N-terminal-like protein; Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB."},{"id":"ENSMUSP00000037867","abundance":0.694,"rank":12384,"name":"Colec10","annotation":"Collectin-10; Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine. Acts as a chemoattractant, probably involved in the regulation of cell migration. Belongs to the COLEC10/COLEC11 family."},{"id":"ENSMUSP00000037423","abundance":0.694,"rank":12385,"name":"Noxa1","annotation":"NADPH oxidase activator 1; Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3."},{"id":"ENSMUSP00000046538","abundance":0.693,"rank":12386,"name":"Osbpl2","annotation":"Oxysterol-binding protein-related protein 2; Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5- bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro); Belongs to the [...] "},{"id":"ENSMUSP00000011776","abundance":0.693,"rank":12387,"name":"Pinlyp","annotation":"Phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein."},{"id":"ENSMUSP00000027027","abundance":0.693,"rank":12388,"name":"Cwf19l2","annotation":"CWF19-like protein 2."},{"id":"ENSMUSP00000026975","abundance":0.693,"rank":12389,"name":"Dnaaf5","annotation":"Dynein assembly factor 5, axonemal; Cytoplasmic protein involved in the delivery of the dynein machinery to the motile cilium. It is required for the assembly of the axonemal dynein inner and outer arms, two structures attached to the peripheral outer doublet A microtubule of the axoneme, that play a crucial role in cilium motility."},{"id":"ENSMUSP00000068550","abundance":0.692,"rank":12390,"name":"Ccser2","annotation":"Serine-rich coiled-coil domain-containing protein 2; Microtubule-binding protein which might play a role in microtubule bundling; Belongs to the CCSER family."},{"id":"ENSMUSP00000047474","abundance":0.691,"rank":12391,"name":"Tceal9","annotation":"Transcription elongation factor A protein-like 9; May be involved in transcriptional regulation; Belongs to the TFS-II family. TFA subfamily."},{"id":"ENSMUSP00000048092","abundance":0.691,"rank":12392,"name":"C3ar1","annotation":"C3a anaphylatoxin chemotactic receptor; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000058697","abundance":0.691,"rank":12393,"name":"Med26","annotation":"Mediator of RNA polymerase II transcription subunit 26; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000028129","abundance":0.69,"rank":12394,"name":"Slc2a8","annotation":"Solute carrier family 2, facilitated glucose transporter member 8; Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Also able to mediate the transport of dehydroascorbate."},{"id":"ENSMUSP00000015628","abundance":0.69,"rank":12395,"name":"Fam163a","annotation":"Protein FAM163A."},{"id":"ENSMUSP00000039041","abundance":0.69,"rank":12396,"name":"Flt3","annotation":"Receptor-type tyrosine-protein kinase FLT3; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only m [...] "},{"id":"ENSMUSP00000020692","abundance":0.69,"rank":12397,"name":"Btg2","annotation":"Protein BTG2; Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity); Belongs to the BTG family."},{"id":"ENSMUSP00000121261","abundance":0.689,"rank":12398,"name":"Dnhd1","annotation":"Dynein heavy chain domain 1."},{"id":"ENSMUSP00000018896","abundance":0.689,"rank":12399,"name":"Tnfsf13","annotation":"Tumor necrosis factor ligand superfamily member 13; Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes."},{"id":"ENSMUSP00000120810","abundance":0.688,"rank":12400,"name":"Slc38a6","annotation":"Probable sodium-coupled neutral amino acid transporter 6; Probable sodium-dependent amino acid/proton antiporter, could be a neuronal transporter for glutamate."},{"id":"ENSMUSP00000064041","abundance":0.688,"rank":12401,"name":"Mogat2","annotation":"2-acylglycerol O-acyltransferase 2; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity."},{"id":"ENSMUSP00000055772","abundance":0.688,"rank":12402,"name":"Secisbp2l","annotation":"Selenocysteine insertion sequence-binding protein 2-like; Binds SECIS (Sec insertion sequence) elements present on selenocysteine (Sec) protein mRNAs, but does not promote Sec incorporation into selenoproteins."},{"id":"ENSMUSP00000122032","abundance":0.688,"rank":12403,"name":"Gm42669","annotation":"AP2-interacting clathrin-endocytosis protein; Involved in clathrin-mediated endocytosis at the synapse. Plays a role in neuronal development and in synaptic vesicle recycling in mature neurons, a process required for normal synaptic transmission."},{"id":"ENSMUSP00000151208","abundance":0.688,"rank":12404,"name":"Olfr661","annotation":"Olfactory receptor MOR40-4."},{"id":"ENSMUSP00000036507","abundance":0.687,"rank":12405,"name":"Ccdc18","annotation":"Coiled-coil domain-containing protein 18."},{"id":"ENSMUSP00000133806","abundance":0.687,"rank":12406,"name":"Dip2c","annotation":"Disco-interacting protein 2 homolog C."},{"id":"ENSMUSP00000054719","abundance":0.687,"rank":12407,"name":"Npas2","annotation":"Neuronal PAS domain-containing protein 2; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, [...] "},{"id":"ENSMUSP00000110230","abundance":0.687,"rank":12408,"name":"Zfp777","annotation":"Zinc finger protein 777."},{"id":"ENSMUSP00000009143","abundance":0.687,"rank":12409,"name":"Bmp7","annotation":"Bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis."},{"id":"ENSMUSP00000034282","abundance":0.687,"rank":12410,"name":"Crispld2","annotation":"Cysteine-rich secretory protein LCCL domain-containing 2; Promotes matrix assembly."},{"id":"ENSMUSP00000046105","abundance":0.686,"rank":12411,"name":"H2-Aa","annotation":"H-2 class II histocompatibility antigen, A-B alpha chain."},{"id":"ENSMUSP00000032760","abundance":0.686,"rank":12412,"name":"Mesp1","annotation":"Mesoderm posterior protein 1; Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways."},{"id":"ENSMUSP00000025966","abundance":0.686,"rank":12413,"name":"Cyp2c55","annotation":"Cytochrome P450 2C55; Metabolizes arachidonic acid mainly to 19- hydroxyeicosatetraenoic acid (HETE); Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000148479","abundance":0.686,"rank":12414,"name":"Mau2","annotation":"MAU2 chromatid cohesion factor homolog; Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodim. eric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin Plays a role in sister chromatid cohesion and normal progression through prometaphase."},{"id":"ENSMUSP00000028106","abundance":0.686,"rank":12415,"name":"Itga8","annotation":"Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons."},{"id":"ENSMUSP00000129019","abundance":0.686,"rank":12416,"name":"Tdrd3","annotation":"Tudor domain-containing protein 3; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By simil [...] "},{"id":"ENSMUSP00000021617","abundance":0.685,"rank":12417,"name":"Asb2","annotation":"Ankyrin repeat and SOCS box protein 2; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family."},{"id":"ENSMUSP00000046787","abundance":0.685,"rank":12418,"name":"Tbr1","annotation":"T-box brain protein 1; Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons."},{"id":"ENSMUSP00000108329","abundance":0.685,"rank":12419,"name":"Tro","annotation":"Tro protein."},{"id":"ENSMUSP00000072686","abundance":0.685,"rank":12420,"name":"Olfr508","annotation":"Olfactory receptor 508; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000028341","abundance":0.685,"rank":12421,"name":"Anapc2","annotation":"Anaphase-promoting complex subunit 2; Together with the RING-H2 protein ANAPC11, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The CDC20-APC/C complex positively re [...] "},{"id":"ENSMUSP00000033127","abundance":0.684,"rank":12422,"name":"Sergef","annotation":"Secretion-regulating guanine nucleotide exchange factor; Probable guanine nucleotide exchange factor (GEF), which may be involved in the secretion process."},{"id":"ENSMUSP00000150166","abundance":0.684,"rank":12423,"name":"Olfr615","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000044441","abundance":0.684,"rank":12424,"name":"Csdc2","annotation":"Cold shock domain-containing protein C2; RNA-binding factor which binds specifically to the very 3'- UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity)."},{"id":"ENSMUSP00000028355","abundance":0.684,"rank":12425,"name":"Pax8","annotation":"Paired box protein Pax-8; Thought to encode a transcription factor. It may have a role in kidney cell differentiation. May play a regulatory role in mammalian development."},{"id":"ENSMUSP00000047931","abundance":0.684,"rank":12426,"name":"C1galt1","annotation":"Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily."},{"id":"ENSMUSP00000078137","abundance":0.684,"rank":12427,"name":"Taar2","annotation":"Trace amine-associated receptor 2; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000108083","abundance":0.683,"rank":12428,"name":"Bclaf3","annotation":"BCLAF1 and THRAP3 family member 3; Belongs to the BCLAF1/THRAP3 family."},{"id":"ENSMUSP00000005600","abundance":0.683,"rank":12429,"name":"Rfx1","annotation":"MHC class II regulatory factor RFX1; Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes (By similarity)."},{"id":"ENSMUSP00000032715","abundance":0.683,"rank":12430,"name":"Prmt3","annotation":"Protein arginine N-methyltransferase 3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family."},{"id":"ENSMUSP00000153854","abundance":0.683,"rank":12431,"name":"Styx","annotation":"Serine/threonine/tyrosine interaction protein."},{"id":"ENSMUSP00000094153","abundance":0.683,"rank":12432,"name":"Gm14698","annotation":"Serine/threonine/tyrosine-interacting protein; Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (By similarity). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (By similarity). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (By similarity). Plays a role in spermatogenesis. Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily."},{"id":"ENSMUSP00000112978","abundance":0.683,"rank":12433,"name":"Casz1","annotation":"Zinc finger protein castor homolog 1; Transcription factor involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7."},{"id":"ENSMUSP00000068450","abundance":0.683,"rank":12434,"name":"Atg4d","annotation":"Cysteine protease ATG4D, mitochondrial; [Cysteine protease ATG4D]: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C- terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms."},{"id":"ENSMUSP00000153605","abundance":0.683,"rank":12435,"name":"Shd","annotation":"SH2 domain-containing adapter protein D; May function as an adapter protein."},{"id":"ENSMUSP00000069562","abundance":0.683,"rank":12436,"name":"D930048N14Rik","annotation":"RIKEN cDNA D930048N14 gene."},{"id":"ENSMUSP00000028902","abundance":0.682,"rank":12437,"name":"Otor","annotation":"Otoraplin; Belongs to the MIA/OTOR family."},{"id":"ENSMUSP00000149234","abundance":0.682,"rank":12438,"name":"Olfr361","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000107333","abundance":0.682,"rank":12439,"name":"Rassf8","annotation":"Ras association domain-containing protein 8."},{"id":"ENSMUSP00000068004","abundance":0.682,"rank":12440,"name":"Tmem179","annotation":"Transmembrane protein 179."},{"id":"ENSMUSP00000046927","abundance":0.681,"rank":12441,"name":"Tmc7","annotation":"Transmembrane channel-like protein 7; Probable ion channel; Belongs to the TMC family."},{"id":"ENSMUSP00000025211","abundance":0.681,"rank":12442,"name":"Mzb1","annotation":"Marginal zone B- and B1-cell-specific protein; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation."},{"id":"ENSMUSP00000091455","abundance":0.681,"rank":12443,"name":"Crhr1","annotation":"Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to st [...] "},{"id":"ENSMUSP00000045282","abundance":0.68,"rank":12444,"name":"Tspan33","annotation":"Tetraspanin-33; Plays an important role in normal erythropoiesis. It has a role in the differentiation of erythroid progenitors. Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7."},{"id":"ENSMUSP00000064404","abundance":0.68,"rank":12445,"name":"Grm7","annotation":"Metabotropic glutamate receptor 7; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity)."},{"id":"ENSMUSP00000048124","abundance":0.68,"rank":12446,"name":"Tent2","annotation":"Poly(A) RNA polymerase GLD2; Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation (By similarity)."},{"id":"ENSMUSP00000050592","abundance":0.679,"rank":12447,"name":"Ercc6l","annotation":"DNA excision repair protein ERCC-6-like; DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro)."},{"id":"ENSMUSP00000097809","abundance":0.679,"rank":12448,"name":"Ttf1","annotation":"Transcription termination factor 1; Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity."},{"id":"ENSMUSP00000150957","abundance":0.679,"rank":12449,"name":"Olfr1457","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000026014","abundance":0.679,"rank":12450,"name":"Efhc2","annotation":"EF-hand domain-containing family member C2."},{"id":"ENSMUSP00000076708","abundance":0.679,"rank":12451,"name":"Dqx1","annotation":"ATP-dependent RNA helicase DQX1."},{"id":"ENSMUSP00000051003","abundance":0.679,"rank":12452,"name":"Hoxc12","annotation":"Homeobox protein Hox-C12; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family."},{"id":"ENSMUSP00000032774","abundance":0.679,"rank":12453,"name":"Ttc23","annotation":"Tetratricopeptide repeat protein 23; Participates positively in the ciliary Hedgehog (Hh) signaling."},{"id":"ENSMUSP00000026084","abundance":0.679,"rank":12454,"name":"Slc18a2","annotation":"Synaptic vesicular amine transporter; Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis (By similarity)."},{"id":"ENSMUSP00000083477","abundance":0.679,"rank":12455,"name":"Vmn2r28","annotation":"Vomeronasal 2, receptor 28."},{"id":"ENSMUSP00000101404","abundance":0.678,"rank":12456,"name":"Prdm2","annotation":"PR domain-containing 2, with ZNF domain."},{"id":"ENSMUSP00000137581","abundance":0.678,"rank":12457,"name":"ENSMUSP00000137581","annotation":"annotation not available"},{"id":"ENSMUSP00000136818","abundance":0.678,"rank":12458,"name":"ENSMUSP00000136818","annotation":"annotation not available"},{"id":"ENSMUSP00000094625","abundance":0.678,"rank":12459,"name":"ENSMUSP00000094625","annotation":"annotation not available"},{"id":"ENSMUSP00000135922","abundance":0.678,"rank":12460,"name":"ENSMUSP00000135922","annotation":"annotation not available"},{"id":"ENSMUSP00000137125","abundance":0.678,"rank":12461,"name":"ENSMUSP00000137125","annotation":"annotation not available"},{"id":"ENSMUSP00000026414","abundance":0.678,"rank":12462,"name":"Dgka","annotation":"Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity."},{"id":"ENSMUSP00000157499","abundance":0.678,"rank":12463,"name":"Vmn1r222","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000140597","abundance":0.677,"rank":12464,"name":"Kansl3","annotation":"KAT8 regulatory NSL complex subunit 3; As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription."},{"id":"ENSMUSP00000137002","abundance":0.677,"rank":12465,"name":"Shisa8","annotation":"Protein shisa-8; May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses."},{"id":"ENSMUSP00000136147","abundance":0.677,"rank":12466,"name":"Pou3f2","annotation":"POU domain, class 3, transcription factor 2; Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes  [...] "},{"id":"ENSMUSP00000123011","abundance":0.677,"rank":12467,"name":"Xaf1","annotation":"XIAP-associated factor 1; Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 fr [...] "},{"id":"ENSMUSP00000137616","abundance":0.677,"rank":12468,"name":"Ankrd44","annotation":"Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates."},{"id":"ENSMUSP00000060517","abundance":0.677,"rank":12469,"name":"Galr3","annotation":"Galanin receptor type 3; Receptor for the hormone galanin and spexin-1."},{"id":"ENSMUSP00000040707","abundance":0.677,"rank":12470,"name":"Heca","annotation":"Hdc homolog, cell cycle regulator."},{"id":"ENSMUSP00000040578","abundance":0.676,"rank":12471,"name":"Bmt2","annotation":"S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] "},{"id":"ENSMUSP00000132453","abundance":0.676,"rank":12472,"name":"Ccr2","annotation":"C-C chemokine receptor type 2; Key functional receptor for CCL2 but can also bind CCL7 and CCL12 chemokines. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Facilitates the [...] "},{"id":"ENSMUSP00000153038","abundance":0.676,"rank":12473,"name":"Slc34a1","annotation":"Sodium-dependent phosphate transport protein 2A; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx."},{"id":"ENSMUSP00000150831","abundance":0.676,"rank":12474,"name":"Olfr690","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000155594","abundance":0.676,"rank":12475,"name":"Smug1","annotation":"Single-strand selective monofunctional uracil DNA glycosylase; Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5- formy [...] "},{"id":"ENSMUSP00000150467","abundance":0.676,"rank":12476,"name":"Olfr453","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000113498","abundance":0.676,"rank":12477,"name":"Adcy9","annotation":"Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and by beta- adrenergic receptors."},{"id":"ENSMUSP00000017348","abundance":0.676,"rank":12478,"name":"Gsdma","annotation":"Gasdermin-A; May promote pyroptosis. Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family."},{"id":"ENSMUSP00000120085","abundance":0.676,"rank":12479,"name":"Cep350","annotation":"Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation."},{"id":"ENSMUSP00000078199","abundance":0.675,"rank":12480,"name":"Chpf","annotation":"Chondroitin sulfate synthase 2; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress (By similarity)."},{"id":"ENSMUSP00000031535","abundance":0.675,"rank":12481,"name":"Hnf1a","annotation":"Hepatocyte nuclear factor 1-alpha; Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. Binds to the inverted palindrome 5'- GTTAATNATTAAC-3'. Activates the transcription of CYP1A2, CYP2E1 and CYP3A11. Belongs to the HNF1 homeobox family."},{"id":"ENSMUSP00000053391","abundance":0.675,"rank":12482,"name":"Il1f9","annotation":"Interleukin-36 gamma; Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses du [...] "},{"id":"ENSMUSP00000041180","abundance":0.675,"rank":12483,"name":"Resf1","annotation":"Retroelement silencing factor 1; Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells."},{"id":"ENSMUSP00000153598","abundance":0.675,"rank":12484,"name":"Kif27","annotation":"Kinesin-like protein KIF27; Plays an essential role in motile ciliogenesis."},{"id":"ENSMUSP00000041751","abundance":0.674,"rank":12485,"name":"Ankrd27","annotation":"Ankyrin repeat domain-containing protein 27; May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (By similarity). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (By similarity). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite [...] "},{"id":"ENSMUSP00000001027","abundance":0.674,"rank":12486,"name":"Aox1","annotation":"Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imid [...] "},{"id":"ENSMUSP00000093433","abundance":0.674,"rank":12487,"name":"Egr4","annotation":"Early growth response protein 4; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000037779","abundance":0.674,"rank":12488,"name":"Bmp8a","annotation":"Bone morphogenetic protein 8A; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Has only marginal osteoinductive activity in mesenchymal progenitor and osteoprogenior cells but shows activity in committed osteoblastic cells."},{"id":"ENSMUSP00000129589","abundance":0.673,"rank":12489,"name":"Cuedc2","annotation":"CUE domain-containing protein 2; Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation. Belongs to the CUEDC2 family."},{"id":"ENSMUSP00000033466","abundance":0.673,"rank":12490,"name":"Cd40lg","annotation":"CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of  [...] "},{"id":"ENSMUSP00000050314","abundance":0.673,"rank":12491,"name":"Duox2","annotation":"Dual oxidase 2."},{"id":"ENSMUSP00000149020","abundance":0.673,"rank":12492,"name":"Usp44","annotation":"Ubiquitin carboxyl-terminal hydrolase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts [...] "},{"id":"ENSMUSP00000086511","abundance":0.673,"rank":12493,"name":"Tcf15","annotation":"Transcription factor 15; May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm."},{"id":"ENSMUSP00000029761","abundance":0.673,"rank":12494,"name":"Myoz2","annotation":"Myozenin-2; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis."},{"id":"ENSMUSP00000023465","abundance":0.673,"rank":12495,"name":"Top3b","annotation":"DNA topoisomerase 3-beta-1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoil [...] "},{"id":"ENSMUSP00000143842","abundance":0.673,"rank":12496,"name":"Zfp958","annotation":"Zinc finger protein 958."},{"id":"ENSMUSP00000015663","abundance":0.673,"rank":12497,"name":"2310057J18Rik","annotation":"Protein LEG1 homolog; May be involved in early liver development. Belongs to the LEG1 family."},{"id":"ENSMUSP00000091477","abundance":0.673,"rank":12498,"name":"Mycbpap","annotation":"MYCBP-associated protein; May play a role in spermatogenesis. May be involved in synaptic processes (By similarity)."},{"id":"ENSMUSP00000087742","abundance":0.673,"rank":12499,"name":"Gjd2","annotation":"Gap junction delta-2 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Delta-type subfamily."},{"id":"ENSMUSP00000037172","abundance":0.672,"rank":12500,"name":"Zc3h12a","annotation":"Endoribonuclease ZC3H12A; Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of mul [...] "},{"id":"ENSMUSP00000069764","abundance":0.672,"rank":12501,"name":"Tmem106c","annotation":"Transmembrane protein 106C."},{"id":"ENSMUSP00000023849","abundance":0.672,"rank":12502,"name":"Noct","annotation":"Nocturnin; Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control. Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis. Plays an  [...] "},{"id":"ENSMUSP00000090717","abundance":0.672,"rank":12503,"name":"Capn9","annotation":"Calpain-9; Calcium-regulated non-lysosomal thiol-protease."},{"id":"ENSMUSP00000078302","abundance":0.672,"rank":12504,"name":"Mctp2","annotation":"Multiple C2 and transmembrane domain-containing protein 2; Might play a role in the development of cardiac outflow tract; Belongs to the MCTP family."},{"id":"ENSMUSP00000072119","abundance":0.672,"rank":12505,"name":"Mageb1","annotation":"Melanoma antigen, family B, 1."},{"id":"ENSMUSP00000032717","abundance":0.672,"rank":12506,"name":"Dbx1","annotation":"Homeobox protein DBX1; Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons."},{"id":"ENSMUSP00000056869","abundance":0.672,"rank":12507,"name":"Cfap70","annotation":"Cilia and flagella-associated protein 70."},{"id":"ENSMUSP00000137280","abundance":0.671,"rank":12508,"name":"Tbc1d7","annotation":"TBC1 domain family member 7; Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is un [...] "},{"id":"ENSMUSP00000043178","abundance":0.671,"rank":12509,"name":"Usp6nl","annotation":"USP6 N-terminal-like protein; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex (By similarity)."},{"id":"ENSMUSP00000029540","abundance":0.671,"rank":12510,"name":"Npr1","annotation":"Atrial natriuretic peptide receptor 1; Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand."},{"id":"ENSMUSP00000083187","abundance":0.67,"rank":12511,"name":"Galnt17","annotation":"Polypeptide N-acetylgalactosaminyltransferase 17; May catalyze the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor."},{"id":"ENSMUSP00000044797","abundance":0.67,"rank":12512,"name":"Cog5","annotation":"Conserved oligomeric Golgi complex subunit 5; Required for normal Golgi function."},{"id":"ENSMUSP00000127351","abundance":0.67,"rank":12513,"name":"Bend3","annotation":"BEN domain-containing protein 3; Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (By similarity). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites. Stimulates the ERCC6L translocase and ATPase activities (By similarity)."},{"id":"ENSMUSP00000034472","abundance":0.67,"rank":12514,"name":"Jam3","annotation":"Junctional adhesion molecule C; Junctional adhesion protein that mediates heterotypic cell- cell interactions with its cognate receptor JAM2 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium. Plays a role in spermatogenesis where JAM2 and JAM3, whi [...] "},{"id":"ENSMUSP00000096871","abundance":0.67,"rank":12515,"name":"Fndc10","annotation":"Fibronectin type III domain-containing protein 10."},{"id":"ENSMUSP00000129280","abundance":0.67,"rank":12516,"name":"Hcar1","annotation":"Hydroxycarboxylic acid receptor 1; Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway."},{"id":"ENSMUSP00000154529","abundance":0.67,"rank":12517,"name":"Vmn1r81","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000064161","abundance":0.669,"rank":12518,"name":"Btnl4","annotation":"Butyrophilin, subfamily 3, member A3."},{"id":"ENSMUSP00000110986","abundance":0.669,"rank":12519,"name":"Pot1a","annotation":"Protection of telomeres protein 1; Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis- inhibition of telomerase. Also acts as a single-stranded telomeric DNA- binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is [...] "},{"id":"ENSMUSP00000113309","abundance":0.669,"rank":12520,"name":"Wdr66","annotation":"Cilia- and flagella-associated protein 251; Involved in spermatozoa motility (By similarity). May also regulate cilium motility through its role in the assembly of the axonemal radial spokes (By similarity)."},{"id":"ENSMUSP00000092163","abundance":0.669,"rank":12521,"name":"Ffar3","annotation":"Free fatty acid receptor 3; G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin- sensitive, G(i/o)-alpha f [...] "},{"id":"ENSMUSP00000047054","abundance":0.668,"rank":12522,"name":"Dym","annotation":"Dymeclin; Necessary for correct organization of Golgi apparatus. Involved in bone development."},{"id":"ENSMUSP00000023444","abundance":0.668,"rank":12523,"name":"Lztr1","annotation":"Leucine-zipper-like transcriptional regulator 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes."},{"id":"ENSMUSP00000083039","abundance":0.668,"rank":12524,"name":"Ifi208","annotation":"Pyrin domain-containing protein 3; Belongs to the HIN-200 family."},{"id":"ENSMUSP00000032218","abundance":0.668,"rank":12525,"name":"Lrrc23","annotation":"Leucine-rich repeat-containing protein 23."},{"id":"ENSMUSP00000095053","abundance":0.667,"rank":12526,"name":"Ccdc185","annotation":"Coiled-coil domain-containing 185."},{"id":"ENSMUSP00000025477","abundance":0.667,"rank":12527,"name":"St8sia3","annotation":"Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase; Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto the terminal sialic acid of an acceptor through alpha-2,8-linkages. Is active with alpha-2,3-linked, alpha-2,6-linked and alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins and glycolipids. Displays preference for substrates with alpha-2,3-linked terminal sialic acid. It can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid; Belongs to the glycosyltransferase 29 family."},{"id":"ENSMUSP00000114087","abundance":0.667,"rank":12528,"name":"Phtf2","annotation":"Putative homeodomain transcription factor 2; May play a role in transcription regulation."},{"id":"ENSMUSP00000071577","abundance":0.667,"rank":12529,"name":"Idua","annotation":"Alpha-L-iduronidase."},{"id":"ENSMUSP00000029654","abundance":0.667,"rank":12530,"name":"Glrb","annotation":"Glycine receptor subunit beta; Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down- regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents."},{"id":"ENSMUSP00000103652","abundance":0.667,"rank":12531,"name":"Gm5114","annotation":"Predicted gene 5114."},{"id":"ENSMUSP00000023449","abundance":0.667,"rank":12532,"name":"Snap29","annotation":"Synaptosomal-associated protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions."},{"id":"ENSMUSP00000031681","abundance":0.667,"rank":12533,"name":"Wnt16","annotation":"Protein Wnt-16; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity)."},{"id":"ENSMUSP00000013458","abundance":0.666,"rank":12534,"name":"Adh4","annotation":"All-trans-retinol dehydrogenase [NAD(+)] ADH4; Catalyzes the NAD-dependent oxidation of either all-trans- retinol or 9-cis-retinol (By similarity). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Also catalyzes the reduction of benzoquinones (By similarity); Belongs to the zinc-containing alcohol dehydrogenase family. Class-II subfamily."},{"id":"ENSMUSP00000012281","abundance":0.666,"rank":12535,"name":"Bmp5","annotation":"Bone morphogenetic protein 5; Induces cartilage and bone formation; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000004728","abundance":0.666,"rank":12536,"name":"Cd33","annotation":"Myeloid cell surface antigen CD33; Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state (By similarity). Preferentially binds sialic acid to the short O-linked glycans of certain mucins."},{"id":"ENSMUSP00000135368","abundance":0.666,"rank":12537,"name":"Gm20708","annotation":"Predicted gene 20708."},{"id":"ENSMUSP00000036580","abundance":0.666,"rank":12538,"name":"Wnt4","annotation":"Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development. Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down- regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Required for norma [...] "},{"id":"ENSMUSP00000015511","abundance":0.666,"rank":12539,"name":"Plxnd1","annotation":"Plexin-D1; Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature."},{"id":"ENSMUSP00000154686","abundance":0.666,"rank":12540,"name":"Smim41","annotation":"Small integral membrane protein 41."},{"id":"ENSMUSP00000126405","abundance":0.665,"rank":12541,"name":"Panx1","annotation":"Pannexin-1; Structural component of the gap junctions and the hemichannels. May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (By similarity)."},{"id":"ENSMUSP00000074799","abundance":0.665,"rank":12542,"name":"Olfr248","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000007444","abundance":0.665,"rank":12543,"name":"Strada","annotation":"STE20-related kinase adapter protein alpha; Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity)."},{"id":"ENSMUSP00000109431","abundance":0.665,"rank":12544,"name":"B3galt5","annotation":"Beta-1,3-galactosyltransferase 5; Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Also catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside GB4, thereby synthesizing the glycolipid GB5, also known as the stage-specific embryonic antigen-3 (SSEA-3); Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000078281","abundance":0.665,"rank":12545,"name":"Arhgef26","annotation":"Rho guanine nucleotide exchange factor (GEF) 26."},{"id":"ENSMUSP00000032703","abundance":0.664,"rank":12546,"name":"Slc7a9","annotation":"B(0,+)-type amino acid transporter 1; Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney proximal tubule. Belongs to the amino acid-polyamine-organocation (APC) superfamily."},{"id":"ENSMUSP00000123935","abundance":0.664,"rank":12547,"name":"Alg12","annotation":"Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase; Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation; Belongs to the glycosyltransferase 22 family."},{"id":"ENSMUSP00000023154","abundance":0.664,"rank":12548,"name":"Cldn1","annotation":"Claudin-1; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. [...] "},{"id":"ENSMUSP00000135292","abundance":0.664,"rank":12549,"name":"Pyy","annotation":"Peptide YY(3-36); This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility."},{"id":"ENSMUSP00000040746","abundance":0.664,"rank":12550,"name":"Cd207","annotation":"C-type lectin domain family 4 member K; Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells."},{"id":"ENSMUSP00000142062","abundance":0.664,"rank":12551,"name":"Pcdhga1","annotation":"Protocadherin gamma subfamily A, 1."},{"id":"ENSMUSP00000092703","abundance":0.663,"rank":12552,"name":"Rapgef1","annotation":"Rap guanine nucleotide exchange factor (GEF) 1."},{"id":"ENSMUSP00000113137","abundance":0.663,"rank":12553,"name":"Abhd3","annotation":"Phospholipase ABHD3; Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids."},{"id":"ENSMUSP00000027687","abundance":0.663,"rank":12554,"name":"Ube2t","annotation":"Ubiquitin-conjugating enzyme E2 T; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using a [...] "},{"id":"ENSMUSP00000002588","abundance":0.663,"rank":12555,"name":"Tiam1","annotation":"T-lymphoma invasion and metastasis-inducing protein 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration (By similarity). Affects invasiveness of T-lymphoma cells. Belongs to the TIAM family."},{"id":"ENSMUSP00000099493","abundance":0.663,"rank":12556,"name":"Per3","annotation":"Period circadian protein homolog 3; Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and [...] "},{"id":"ENSMUSP00000032891","abundance":0.663,"rank":12557,"name":"Smg1","annotation":"Serine/threonine-protein kinase SMG1; Serine/threonine protein kinase involved in both mRNA surveillance and genotoxic stress response pathways. Recognizes the substrate consensus sequence [ST]-Q. Plays a central role in nonsense- mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating UPF1/RENT1. Recruited by release factors to stalled ribosomes together with SMG8 and SMG9 (forming the SMG1C protein kinase complex), and UPF1 to form the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. In EJC-dependent NMD, the SURF complex associates with the exon junction compl [...] "},{"id":"ENSMUSP00000092810","abundance":0.663,"rank":12558,"name":"Srbd1","annotation":"S1 RNA-binding domain-containing protein 1."},{"id":"ENSMUSP00000022593","abundance":0.663,"rank":12559,"name":"Akap11","annotation":"A kinase (PRKA) anchor protein 11."},{"id":"ENSMUSP00000114686","abundance":0.662,"rank":12560,"name":"Mamstr","annotation":"MEF2-activating motif and SAP domain-containing transcriptional regulator; Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation."},{"id":"ENSMUSP00000105482","abundance":0.662,"rank":12561,"name":"Ankrd36","annotation":"Ankyrin repeat domain 36."},{"id":"ENSMUSP00000023535","abundance":0.662,"rank":12562,"name":"Iqcb1","annotation":"IQ calmodulin-binding motif-containing protein 1; Involved in ciliogenesis. The function in an early step in cilia formation depends on its association with CEP290/NPHP6 (By similarity). Involved in regulation of the BBSome complex integrity, specifically for presence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (By similarity)."},{"id":"ENSMUSP00000073546","abundance":0.662,"rank":12563,"name":"Nrg1","annotation":"Neuregulin-1 type III beta1-a."},{"id":"ENSMUSP00000158607","abundance":0.662,"rank":12564,"name":"Arhgap33os","annotation":"Rho GTPase-activating protein 33, opposite strand."},{"id":"ENSMUSP00000149442","abundance":0.661,"rank":12565,"name":"Olfr1195","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149586","abundance":0.661,"rank":12566,"name":"Olfr1199","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000064823","abundance":0.661,"rank":12567,"name":"Klf2","annotation":"Krueppel-like factor 2; Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000022358","abundance":0.661,"rank":12568,"name":"Zswim8","annotation":"Zinc finger SWIM domain-containing protein 8."},{"id":"ENSMUSP00000071840","abundance":0.661,"rank":12569,"name":"Bloc1s4","annotation":"Biogenesis of lysosome-related organelles complex 1 subunit 4; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking."},{"id":"ENSMUSP00000018569","abundance":0.661,"rank":12570,"name":"Dhx40","annotation":"Probable ATP-dependent RNA helicase DHX40; Probable ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DEAH subfamily."},{"id":"ENSMUSP00000062345","abundance":0.66,"rank":12571,"name":"Eid2","annotation":"EP300-interacting inhibitor of differentiation 2; Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3- dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex (By similarity)."},{"id":"ENSMUSP00000033965","abundance":0.66,"rank":12572,"name":"Tenm3","annotation":"Teneurin-3; Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Promotes homophilic adhesion in a splicing isoform-dependent manner: most isoforms (isoform-type A and type-B) can mediate homophilic interaction. Promotes axon guidance. Required for  [...] "},{"id":"ENSMUSP00000139865","abundance":0.66,"rank":12573,"name":"Sytl2","annotation":"Synaptotagmin-like protein 2; Isoform 11 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. Required for cytotoxic granule docking at the immunologic synapse. Isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology. Isoform 1 acts as a positive mediator of mucus secretion by the surface mucus cells of the stomach. Mediates basal mucus secretion by gastric surface cells by promoting the proper granule biognesis and docking of mu [...] "},{"id":"ENSMUSP00000057828","abundance":0.659,"rank":12574,"name":"Tyw3","annotation":"tRNA wybutosine-synthesizing protein 3 homolog; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity)."},{"id":"ENSMUSP00000144480","abundance":0.659,"rank":12575,"name":"Zfp799","annotation":"Zinc finger protein 799."},{"id":"ENSMUSP00000107089","abundance":0.659,"rank":12576,"name":"Kbtbd4","annotation":"Kelch repeat and BTB domain-containing protein 4."},{"id":"ENSMUSP00000006692","abundance":0.659,"rank":12577,"name":"Mvd","annotation":"Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes; Belongs to the diphosphomevalonate decarboxylase family."},{"id":"ENSMUSP00000023146","abundance":0.659,"rank":12578,"name":"Nubp1","annotation":"Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Implicated in the regulation of centrosome duplication. Negatively regulates cilium formation and structure."},{"id":"ENSMUSP00000077080","abundance":0.658,"rank":12579,"name":"Unc5b","annotation":"Netrin receptor UNC5B; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity). Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin. It also acts as a dependence receptor required for apoptosis induction when not associated with net [...] "},{"id":"ENSMUSP00000058613","abundance":0.658,"rank":12580,"name":"Sorl1","annotation":"Sortilin-related receptor; Sorting receptor that directs several proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting. Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated. May also sort newly produced amyloid-beta peptides to lysosomes for catabolism. Does not affect APP trafficking from the endoplasmic r [...] "},{"id":"ENSMUSP00000095953","abundance":0.658,"rank":12581,"name":"Scap","annotation":"Sterol regulatory element-binding protein cleavage-activating protein; Escort protein required for cholesterol as well as lipid homeostasis. Regulates export of the SCAP/SREBF complex from the ER upon low cholesterol. Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations trigger release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transport to the Golgi complex, prot [...] "},{"id":"ENSMUSP00000120658","abundance":0.658,"rank":12582,"name":"Saal1","annotation":"Protein SAAL1; Plays a role in promoting the proliferation of synovial fibroblasts in response to proinflammatory stimuli. Belongs to the SAAL1 family."},{"id":"ENSMUSP00000002350","abundance":0.658,"rank":12583,"name":"Ciao3","annotation":"Cytosolic iron-sulfur assembly component 3; Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity)."},{"id":"ENSMUSP00000074758","abundance":0.657,"rank":12584,"name":"Unc5c","annotation":"Netrin receptor UNC5C; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon gu [...] "},{"id":"ENSMUSP00000149821","abundance":0.657,"rank":12585,"name":"Olfr222","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000031414","abundance":0.657,"rank":12586,"name":"Brap","annotation":"BRCA1-associated protein; Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport (By similarity)."},{"id":"ENSMUSP00000097221","abundance":0.656,"rank":12587,"name":"Fibin","annotation":"Fin bud initiation factor homolog."},{"id":"ENSMUSP00000069319","abundance":0.656,"rank":12588,"name":"Ly9","annotation":"T-lymphocyte surface antigen Ly-9; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophil [...] "},{"id":"ENSMUSP00000060650","abundance":0.656,"rank":12589,"name":"Apol10a","annotation":"Apolipoprotein L 10A."},{"id":"ENSMUSP00000092832","abundance":0.656,"rank":12590,"name":"Capn13","annotation":"Calpain-13; Probable non-lysosomal thiol-protease."},{"id":"ENSMUSP00000105953","abundance":0.655,"rank":12591,"name":"Fbln7","annotation":"Fibulin-7; An adhesion molecule that interacts with extracellular matrix molecules in developing teeth and may play important roles in differentiation and maintenance of odontoblasts as well as in dentin formation; Belongs to the fibulin family."},{"id":"ENSMUSP00000136621","abundance":0.654,"rank":12592,"name":"Gpr161","annotation":"G-protein coupled receptor 161; Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signalin [...] "},{"id":"ENSMUSP00000022663","abundance":0.654,"rank":12593,"name":"Tnfrsf10b","annotation":"Tumor necrosis factor receptor superfamily member 10B; Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis."},{"id":"ENSMUSP00000153766","abundance":0.654,"rank":12594,"name":"Vmn1r213","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000018516","abundance":0.654,"rank":12595,"name":"Cep95","annotation":"Centrosomal protein of 95 kDa."},{"id":"ENSMUSP00000138049","abundance":0.653,"rank":12596,"name":"Rd3","annotation":"Protein RD3; Plays a critical role in the regulation of enzymes involved in nucleotide cycle in photoreceptors. Inhibits the basal catalytic activity and the GCAP- stimulated activity of GUCY2E and GUCY2F, two retinal guanylyl cyclases involved in the production of cGMP in photoreceptors. Involved in the transport of GUCY2E and GUCY2F to their target sites in the photoreceptor outer segment. Up-regulates the activity of GUK1, a kinase that plays also an essential role for recycling GMP and indirectly, cGMP (By similarity). Plays an important role for the survival of rods and cones in t [...] "},{"id":"ENSMUSP00000032265","abundance":0.653,"rank":12597,"name":"Olr1","annotation":"Oxidized low-density lipoprotein receptor 1, soluble form; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses includin [...] "},{"id":"ENSMUSP00000138188","abundance":0.653,"rank":12598,"name":"Baiap3","annotation":"BAI1-associated protein 3; Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans- Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters [...] "},{"id":"ENSMUSP00000052816","abundance":0.653,"rank":12599,"name":"Antxrl","annotation":"Anthrax toxin receptor-like."},{"id":"ENSMUSP00000138814","abundance":0.653,"rank":12600,"name":"Tlr11","annotation":"Toll-like receptor 11; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family."},{"id":"ENSMUSP00000074988","abundance":0.653,"rank":12601,"name":"Cenph","annotation":"Centromere protein H; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate (By similarity)."},{"id":"ENSMUSP00000010250","abundance":0.652,"rank":12602,"name":"Slc22a6","annotation":"Solute carrier family 22 member 6; Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1- propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2-phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetid [...] "},{"id":"ENSMUSP00000079395","abundance":0.652,"rank":12603,"name":"Deaf1","annotation":"Deformed epidermal autoregulatory factor 1 homolog; Transcription factor that binds to sequence with multiple copies of 5'-TTC[CG]G-3' present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) 5'-AGGGTTCACCGAAAGTTCA-3'. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction (By similarity). Regulates epithelial cell proliferation and side-branching in the mammary gland. Required for neural tube closure and skeletal patterning. Contro [...] "},{"id":"ENSMUSP00000139752","abundance":0.652,"rank":12604,"name":"Krtap5-1","annotation":"Keratin-associated protein 5-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family."},{"id":"ENSMUSP00000113545","abundance":0.652,"rank":12605,"name":"Syt8","annotation":"Synaptotagmin-8; Involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells; Belongs to the synaptotagmin family."},{"id":"ENSMUSP00000019464","abundance":0.652,"rank":12606,"name":"Noxo1","annotation":"NADPH oxidase organizer 1; Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity."},{"id":"ENSMUSP00000149730","abundance":0.652,"rank":12607,"name":"Olfr1275","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000137070","abundance":0.652,"rank":12608,"name":"Ptrhd1","annotation":"Putative peptidyl-tRNA hydrolase PTRHD1."},{"id":"ENSMUSP00000046705","abundance":0.652,"rank":12609,"name":"Lgi3","annotation":"Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis."},{"id":"ENSMUSP00000146700","abundance":0.652,"rank":12610,"name":"Fam169b","annotation":"Protein FAM169B; Belongs to the FAM169 family."},{"id":"ENSMUSP00000104235","abundance":0.651,"rank":12611,"name":"Elp5","annotation":"Elongator complex protein 5; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in cell migration. May be involved in TP53-mediated transcriptional regulation (By similarity)."},{"id":"ENSMUSP00000103245","abundance":0.651,"rank":12612,"name":"Klf4","annotation":"Krueppel-like factor 4; Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also fu [...] "},{"id":"ENSMUSP00000071777","abundance":0.65,"rank":12613,"name":"Myo15","annotation":"Unconventional myosin-XV; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity). Required for the arrangement of stereocilia in mature hair bundles."},{"id":"ENSMUSP00000026360","abundance":0.65,"rank":12614,"name":"Itgb8","annotation":"Integrin beta-8; Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta- 1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs). Required during vasculogenesis."},{"id":"ENSMUSP00000022791","abundance":0.65,"rank":12615,"name":"Fbxo4","annotation":"F-box only protein 4; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (By similarity)."},{"id":"ENSMUSP00000021818","abundance":0.65,"rank":12616,"name":"Cenpp","annotation":"Centromere protein P; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity); Belongs to the CENP-P/CTF19 family."},{"id":"ENSMUSP00000158342","abundance":0.65,"rank":12617,"name":"Nmrk1","annotation":"Nicotinamide riboside kinase 1; Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN)."},{"id":"ENSMUSP00000045024","abundance":0.649,"rank":12618,"name":"Fam151b","annotation":"Family with sequence similarity 151, member B."},{"id":"ENSMUSP00000058860","abundance":0.649,"rank":12619,"name":"AU021092","annotation":"UPF0764 protein C16orf89 homolog."},{"id":"ENSMUSP00000052929","abundance":0.649,"rank":12620,"name":"Rhox11","annotation":"Reproductive homeobox on X chromosome 11."},{"id":"ENSMUSP00000145946","abundance":0.649,"rank":12621,"name":"Olfr173","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000092700","abundance":0.648,"rank":12622,"name":"Olfr275","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000046625","abundance":0.648,"rank":12623,"name":"Inpp5j","annotation":"Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A; Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4- trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles (By similarity)."},{"id":"ENSMUSP00000045103","abundance":0.647,"rank":12624,"name":"E330009J07Rik","annotation":"DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family."},{"id":"ENSMUSP00000039482","abundance":0.647,"rank":12625,"name":"Rsbn1l","annotation":"Round spermatid basic protein 1-like."},{"id":"ENSMUSP00000130708","abundance":0.647,"rank":12626,"name":"Lrch3","annotation":"DISP complex protein LRCH3; As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton."},{"id":"ENSMUSP00000022081","abundance":0.647,"rank":12627,"name":"Spata9","annotation":"Spermatogenesis-associated protein 9; May play at role in testicular development/spermatogenesis and may be an important factor in male infertility."},{"id":"ENSMUSP00000150285","abundance":0.647,"rank":12628,"name":"Olfr1020","annotation":"Olfactory receptor 1020; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000051922","abundance":0.647,"rank":12629,"name":"Hectd3","annotation":"E3 ubiquitin-protein ligase HECTD3; E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP (By similarity). Mediates also ubiquitination of STX8."},{"id":"ENSMUSP00000025823","abundance":0.647,"rank":12630,"name":"Rce1","annotation":"CAAX prenyl protease 2; Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K- Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity)."},{"id":"ENSMUSP00000091310","abundance":0.647,"rank":12631,"name":"Sox14","annotation":"Transcription factor SOX-14; Acts as a negative regulator of transcription."},{"id":"ENSMUSP00000047547","abundance":0.647,"rank":12632,"name":"Serinc5","annotation":"Serine incorporator 5; Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting early step of viral infection and impairing the ability of the viral particle to translocate its content to the cytoplasm (By similarity). Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity); Belongs to the TDE1 family."},{"id":"ENSMUSP00000101527","abundance":0.647,"rank":12633,"name":"Tmem222","annotation":"Transmembrane protein 222."},{"id":"ENSMUSP00000138536","abundance":0.647,"rank":12634,"name":"Rnf113a2","annotation":"Ring finger protein 113A2."},{"id":"ENSMUSP00000050404","abundance":0.646,"rank":12635,"name":"Paip2b","annotation":"Polyadenylate-binding protein-interacting protein 2B; Inhibits translation of capped and polyadenylated mRNAs by displacing PABPC1 from the poly(A) tail. Belongs to the PAIP2 family."},{"id":"ENSMUSP00000148967","abundance":0.646,"rank":12636,"name":"Olfr600","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000030747","abundance":0.646,"rank":12637,"name":"Casp9","annotation":"Caspase-9 subunit p10; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) (By similarity)."},{"id":"ENSMUSP00000137079","abundance":0.646,"rank":12638,"name":"Cpeb1","annotation":"Cytoplasmic polyadenylation element-binding protein 1; Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradat [...] "},{"id":"ENSMUSP00000029673","abundance":0.646,"rank":12639,"name":"Efna3","annotation":"Ephrin-A3; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling."},{"id":"ENSMUSP00000052320","abundance":0.645,"rank":12640,"name":"Tigd4","annotation":"Tigger transposable element-derived protein 4."},{"id":"ENSMUSP00000049640","abundance":0.645,"rank":12641,"name":"Grem2","annotation":"Gremlin-2; Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. Belongs to the DAN family."},{"id":"ENSMUSP00000038589","abundance":0.645,"rank":12642,"name":"Ccdc32","annotation":"Coiled-coil domain-containing protein 32."},{"id":"ENSMUSP00000128586","abundance":0.645,"rank":12643,"name":"Nbeal2","annotation":"Neurobeachin-like protein 2; Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis (By similarity)."},{"id":"ENSMUSP00000075204","abundance":0.645,"rank":12644,"name":"Atp13a5","annotation":"Probable cation-transporting ATPase 13A5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily."},{"id":"ENSMUSP00000141418","abundance":0.644,"rank":12645,"name":"Gm21366","annotation":"Predicted gene, 21366."},{"id":"ENSMUSP00000141784","abundance":0.644,"rank":12646,"name":"Gm31571","annotation":"Predicted gene, 31571."},{"id":"ENSMUSP00000141092","abundance":0.644,"rank":12647,"name":"Gm21650","annotation":"Predicted gene, 21650."},{"id":"ENSMUSP00000140067","abundance":0.644,"rank":12648,"name":"Gm20888","annotation":"Predicted gene, 20888."},{"id":"ENSMUSP00000140500","abundance":0.644,"rank":12649,"name":"Gm20855","annotation":"Predicted gene, 20855."},{"id":"ENSMUSP00000140733","abundance":0.644,"rank":12650,"name":"Gm20908","annotation":"Predicted gene, 20908."},{"id":"ENSMUSP00000140706","abundance":0.644,"rank":12651,"name":"Gm21760","annotation":"Predicted gene, 21760."},{"id":"ENSMUSP00000140850","abundance":0.644,"rank":12652,"name":"Gm21409","annotation":"Predicted gene, 21409."},{"id":"ENSMUSP00000140010","abundance":0.644,"rank":12653,"name":"Gm21858","annotation":"Predicted gene, 21858."},{"id":"ENSMUSP00000141039","abundance":0.644,"rank":12654,"name":"Gm20894","annotation":"Predicted gene, 20894."},{"id":"ENSMUSP00000139400","abundance":0.644,"rank":12655,"name":"Gm21209","annotation":"Predicted gene, 20843."},{"id":"ENSMUSP00000139621","abundance":0.644,"rank":12656,"name":"Gm29564","annotation":"Predicted gene, 21760."},{"id":"ENSMUSP00000139992","abundance":0.644,"rank":12657,"name":"Gm28827","annotation":"Predicted gene 28827."},{"id":"ENSMUSP00000140162","abundance":0.644,"rank":12658,"name":"Gm21317","annotation":"Predicted gene, 21317."},{"id":"ENSMUSP00000141119","abundance":0.644,"rank":12659,"name":"Gm20903","annotation":"Predicted gene, 20903."},{"id":"ENSMUSP00000140088","abundance":0.644,"rank":12660,"name":"Gm29110","annotation":"Predicted gene 29110."},{"id":"ENSMUSP00000140340","abundance":0.644,"rank":12661,"name":"Sly","annotation":"Sycp3 like Y-linked."},{"id":"ENSMUSP00000139807","abundance":0.644,"rank":12662,"name":"Gm21117","annotation":"Predicted gene, 21117."},{"id":"ENSMUSP00000140644","abundance":0.644,"rank":12663,"name":"Gm28897","annotation":"Predicted gene 28897."},{"id":"ENSMUSP00000140565","abundance":0.644,"rank":12664,"name":"Gm20817","annotation":"Predicted gene, 20817."},{"id":"ENSMUSP00000140730","abundance":0.644,"rank":12665,"name":"Gm20905","annotation":"Predicted gene, 20905."},{"id":"ENSMUSP00000140468","abundance":0.644,"rank":12666,"name":"Gm20931","annotation":"Predicted gene, 20931."},{"id":"ENSMUSP00000141004","abundance":0.644,"rank":12667,"name":"Gm20850","annotation":"Predicted gene, 20850."},{"id":"ENSMUSP00000139596","abundance":0.644,"rank":12668,"name":"Gm20896","annotation":"Predicted gene, 20896."},{"id":"ENSMUSP00000140431","abundance":0.644,"rank":12669,"name":"Gm21095","annotation":"Predicted gene, 21095."},{"id":"ENSMUSP00000141356","abundance":0.644,"rank":12670,"name":"Gm30737","annotation":"Predicted gene, 30737."},{"id":"ENSMUSP00000140305","abundance":0.644,"rank":12671,"name":"Gm20906","annotation":"Predicted gene, 20906."},{"id":"ENSMUSP00000141776","abundance":0.644,"rank":12672,"name":"Gm29866","annotation":"Predicted gene, 29866."},{"id":"ENSMUSP00000140794","abundance":0.644,"rank":12673,"name":"Gm21518","annotation":"Predicted gene, 21518."},{"id":"ENSMUSP00000139649","abundance":0.644,"rank":12674,"name":"Gm20929","annotation":"Predicted gene, 20929."},{"id":"ENSMUSP00000140064","abundance":0.644,"rank":12675,"name":"Gm20937","annotation":"Predicted gene, 20937."},{"id":"ENSMUSP00000141239","abundance":0.644,"rank":12676,"name":"Gm35134","annotation":"Predicted gene, 35134."},{"id":"ENSMUSP00000139722","abundance":0.644,"rank":12677,"name":"Gm20870","annotation":"Predicted gene, 20870."},{"id":"ENSMUSP00000140944","abundance":0.644,"rank":12678,"name":"Gm20835","annotation":"Predicted gene, 20835."},{"id":"ENSMUSP00000140668","abundance":0.644,"rank":12679,"name":"Gm21497","annotation":"Predicted gene, 21497."},{"id":"ENSMUSP00000140851","abundance":0.644,"rank":12680,"name":"Gm21627","annotation":"Predicted gene, 21627."},{"id":"ENSMUSP00000140679","abundance":0.644,"rank":12681,"name":"Gm21865","annotation":"Predicted gene, 21865."},{"id":"ENSMUSP00000140238","abundance":0.644,"rank":12682,"name":"Gm21477","annotation":"Predicted gene, 21477."},{"id":"ENSMUSP00000140105","abundance":0.644,"rank":12683,"name":"Gm20843","annotation":"Predicted gene, 20843."},{"id":"ENSMUSP00000140689","abundance":0.644,"rank":12684,"name":"Gm20897","annotation":"Predicted gene, 20897."},{"id":"ENSMUSP00000140666","abundance":0.644,"rank":12685,"name":"Gm20814","annotation":"Predicted gene, 20814."},{"id":"ENSMUSP00000140607","abundance":0.644,"rank":12686,"name":"Gm20916","annotation":"Predicted gene, 20916."},{"id":"ENSMUSP00000140542","abundance":0.644,"rank":12687,"name":"Gm20883","annotation":"Predicted gene, 20883."},{"id":"ENSMUSP00000140720","abundance":0.644,"rank":12688,"name":"Gm28576","annotation":"Predicted gene 28576."},{"id":"ENSMUSP00000139793","abundance":0.644,"rank":12689,"name":"Gm28553","annotation":"Predicted gene, 20817."},{"id":"ENSMUSP00000140933","abundance":0.644,"rank":12690,"name":"Gm21294","annotation":"Predicted gene, 21294."},{"id":"ENSMUSP00000139478","abundance":0.644,"rank":12691,"name":"Gm20869","annotation":"Predicted gene, 20814."},{"id":"ENSMUSP00000139882","abundance":0.644,"rank":12692,"name":"Gm21258","annotation":"Predicted gene, 20736."},{"id":"ENSMUSP00000140653","abundance":0.644,"rank":12693,"name":"Gm28998","annotation":"Predicted gene 28576."},{"id":"ENSMUSP00000140477","abundance":0.644,"rank":12694,"name":"Gm21173","annotation":"Predicted gene, 21173."},{"id":"ENSMUSP00000140677","abundance":0.644,"rank":12695,"name":"Gm20920","annotation":"Predicted gene, 20920."},{"id":"ENSMUSP00000151125","abundance":0.644,"rank":12696,"name":"Olfr605","annotation":"Olfactory receptor 605."},{"id":"ENSMUSP00000021164","abundance":0.644,"rank":12697,"name":"Pimreg","annotation":"Protein PIMREG; During mitosis, may play a role in the metaphase-to-anaphase transition."},{"id":"ENSMUSP00000024049","abundance":0.644,"rank":12698,"name":"Bmp15","annotation":"Bone morphogenetic protein 15; May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth (By similarity); Belongs to the TGF-beta family."},{"id":"ENSMUSP00000039094","abundance":0.644,"rank":12699,"name":"Atpsckmt","annotation":"ATP synthase subunit C lysine N-methyltransferase; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia."},{"id":"ENSMUSP00000076514","abundance":0.644,"rank":12700,"name":"Atrnl1","annotation":"Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis."},{"id":"ENSMUSP00000090568","abundance":0.644,"rank":12701,"name":"Ankrd13b","annotation":"Ankyrin repeat domain-containing protein 13B; Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity)."},{"id":"ENSMUSP00000041328","abundance":0.644,"rank":12702,"name":"Caskin2","annotation":"Caskin-2."},{"id":"ENSMUSP00000114787","abundance":0.644,"rank":12703,"name":"Ccdc13","annotation":"Coiled-coil domain-containing protein 13; Required for primary cilia formation and promotes the localization of the ciliopathy protein BBS4 to both centriolar satellites and cilia."},{"id":"ENSMUSP00000089860","abundance":0.644,"rank":12704,"name":"Ccdc38","annotation":"Coiled-coil domain-containing protein 38."},{"id":"ENSMUSP00000027164","abundance":0.643,"rank":12705,"name":"Ctla4","annotation":"Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28."},{"id":"ENSMUSP00000154665","abundance":0.643,"rank":12706,"name":"Vmn1r34","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000048530","abundance":0.643,"rank":12707,"name":"Btbd10","annotation":"BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and in accelerating the growth of pancreatic beta cells."},{"id":"ENSMUSP00000032317","abundance":0.642,"rank":12708,"name":"Tas2r103","annotation":"Taste receptor type 2 member 103; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5."},{"id":"ENSMUSP00000041951","abundance":0.642,"rank":12709,"name":"Gab3","annotation":"GRB2-associated-binding protein 3."},{"id":"ENSMUSP00000102415","abundance":0.642,"rank":12710,"name":"Fyb2","annotation":"FYN-binding protein 2; Adapter protein that plays a role in T-cell receptor (TCR)- mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation."},{"id":"ENSMUSP00000142130","abundance":0.642,"rank":12711,"name":"Fer1l5","annotation":"Fer-1-like protein 5; Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation."},{"id":"ENSMUSP00000036847","abundance":0.642,"rank":12712,"name":"Mbd5","annotation":"Methyl-CpG-binding domain protein 5; Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro) (By similarity)."},{"id":"ENSMUSP00000128828","abundance":0.642,"rank":12713,"name":"Cdkn1c","annotation":"Cyclin-dependent kinase inhibitor 1C; Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life."},{"id":"ENSMUSP00000035246","abundance":0.642,"rank":12714,"name":"Abcg8","annotation":"ATP-binding cassette sub-family G member 8; ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Plays an important role in preventing the accumulation of dietary plant sterols in the body. Required for normal sterol homeostasis. The heterodimer with ABCG5 has ATPase activity."},{"id":"ENSMUSP00000149565","abundance":0.641,"rank":12715,"name":"Olfr1477","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000080596","abundance":0.641,"rank":12716,"name":"Zfp341","annotation":"Zinc finger protein 341."},{"id":"ENSMUSP00000070685","abundance":0.641,"rank":12717,"name":"Zfp747","annotation":"Zinc finger protein 747."},{"id":"ENSMUSP00000056728","abundance":0.641,"rank":12718,"name":"Rarres1","annotation":"Retinoic acid receptor responder (tazarotene-induced) 1."},{"id":"ENSMUSP00000097336","abundance":0.64,"rank":12719,"name":"B3galnt2","annotation":"UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2; Beta-1,3-N-acetylgalactosaminyltransferase that synthesizes a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- and O- glycans. Has no galactose nor galactosaminyl transferase activity toward any acceptor substrate. Involved in alpha-dystroglycan (DAG1) glycosylation: acts coordinately with GTDC2/POMGnT2 to synthesize a GalNAc-beta3-GlcNAc-beta-terminus at the 4-position of protein O- mannose in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (pho [...] "},{"id":"ENSMUSP00000156690","abundance":0.64,"rank":12720,"name":"Vmn1r228","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000098419","abundance":0.64,"rank":12721,"name":"Dusp16","annotation":"Dual-specificity phosphatase 16."},{"id":"ENSMUSP00000093770","abundance":0.64,"rank":12722,"name":"Tigit","annotation":"T-cell immunoreceptor with Ig and ITIM domains; Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells."},{"id":"ENSMUSP00000048240","abundance":0.64,"rank":12723,"name":"Gpbp1","annotation":"Vasculin; Functions as a GC-rich promoter-specific transactivating transcription factor."},{"id":"ENSMUSP00000096930","abundance":0.639,"rank":12724,"name":"Rasgrf2","annotation":"Ras-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation."},{"id":"ENSMUSP00000062045","abundance":0.639,"rank":12725,"name":"Cldn14","annotation":"Claudin-14; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity."},{"id":"ENSMUSP00000130343","abundance":0.639,"rank":12726,"name":"Trim67","annotation":"Tripartite motif-containing protein 67."},{"id":"ENSMUSP00000032128","abundance":0.639,"rank":12727,"name":"Gkn2","annotation":"Gastrokine-2."},{"id":"ENSMUSP00000106013","abundance":0.637,"rank":12728,"name":"Ripor2","annotation":"Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (By similarity). Involved also in the regulation of neutrophil polarization, chemotaxis an [...] "},{"id":"ENSMUSP00000142051","abundance":0.637,"rank":12729,"name":"Olfr414","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000031333","abundance":0.636,"rank":12730,"name":"Gtf2h3","annotation":"General transcription factor IIH subunit 3; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] "},{"id":"ENSMUSP00000023151","abundance":0.636,"rank":12731,"name":"Bcl6","annotation":"B-cell lymphoma 6 protein homolog; Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, repres [...] "},{"id":"ENSMUSP00000110074","abundance":0.636,"rank":12732,"name":"Btg4","annotation":"Protein BTG4; Shows marked antiproliferative activity, being able to induce G(1) arrest."},{"id":"ENSMUSP00000113395","abundance":0.636,"rank":12733,"name":"Prkd3","annotation":"Serine/threonine-protein kinase D3; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily."},{"id":"ENSMUSP00000026993","abundance":0.636,"rank":12734,"name":"Tspan17","annotation":"Tetraspanin-17; Regulates ADAM10 maturation."},{"id":"ENSMUSP00000137066","abundance":0.636,"rank":12735,"name":"Btbd35f27","annotation":"BTB domain-containing 35, family member 27."},{"id":"ENSMUSP00000140483","abundance":0.636,"rank":12736,"name":"Muc6","annotation":"Mucin-6; May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis."},{"id":"ENSMUSP00000090559","abundance":0.635,"rank":12737,"name":"Gm10277","annotation":"Predicted gene 10277."},{"id":"ENSMUSP00000102160","abundance":0.635,"rank":12738,"name":"Knop1","annotation":"Lysine-rich nucleolar protein 1."},{"id":"ENSMUSP00000149160","abundance":0.635,"rank":12739,"name":"Olfr516","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000156337","abundance":0.635,"rank":12740,"name":"Stfa1","annotation":"Stefin-1; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family."},{"id":"ENSMUSP00000118793","abundance":0.635,"rank":12741,"name":"1700029H14Rik","annotation":"RIKEN cDNA 1700029H14 gene."},{"id":"ENSMUSP00000021884","abundance":0.635,"rank":12742,"name":"Ctla2b","annotation":"Protein CTLA-2-beta; Not known, expressed in activated T-cell."},{"id":"ENSMUSP00000096377","abundance":0.635,"rank":12743,"name":"Ccdc61","annotation":"Coiled-coil domain-containing protein 61."},{"id":"ENSMUSP00000103902","abundance":0.635,"rank":12744,"name":"Lrriq4","annotation":"Leucine-rich repeat and IQ domain-containing protein 4."},{"id":"ENSMUSP00000031967","abundance":0.635,"rank":12745,"name":"Prss37","annotation":"Probable inactive serine protease 37; Plays a role in male fertility. May have a role in sperm migration or binding to zona-intact eggs. Involved in the activation of the proacrosin/acrosin system (By similarity)."},{"id":"ENSMUSP00000030826","abundance":0.634,"rank":12746,"name":"Slc2a5","annotation":"Solute carrier family 2, facilitated glucose transporter member 5; Functions as a fructose transporter that has only low activity with other monosaccharides. Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake."},{"id":"ENSMUSP00000099696","abundance":0.634,"rank":12747,"name":"Akirin1","annotation":"Akirin-1; Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway. Belongs to the akirin family."},{"id":"ENSMUSP00000101022","abundance":0.634,"rank":12748,"name":"Ccdc105","annotation":"Coiled-coil domain-containing protein 105."},{"id":"ENSMUSP00000033335","abundance":0.634,"rank":12749,"name":"Akip1","annotation":"A-kinase-interacting protein 1; Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade (By similarity)."},{"id":"ENSMUSP00000006818","abundance":0.634,"rank":12750,"name":"Tcf23","annotation":"Transcription factor 23; Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. May be involved in the regulation or modulation of smooth muscle contraction of the uterus during pregnancy and particularly around the time of delivery. Seems to play a role in the inhibition of myogenesis."},{"id":"ENSMUSP00000031145","abundance":0.634,"rank":12751,"name":"Pdcl2","annotation":"Phosducin-like protein 2; May play a role in germ cell maturation."},{"id":"ENSMUSP00000127513","abundance":0.633,"rank":12752,"name":"Vmn2r4","annotation":"Vomeronasal 2, receptor 4."},{"id":"ENSMUSP00000037129","abundance":0.633,"rank":12753,"name":"Tie1","annotation":"Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis."},{"id":"ENSMUSP00000133059","abundance":0.633,"rank":12754,"name":"Gm4884","annotation":"Predicted gene 4884."},{"id":"ENSMUSP00000059772","abundance":0.633,"rank":12755,"name":"Pqlc2","annotation":"Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes."},{"id":"ENSMUSP00000029570","abundance":0.633,"rank":12756,"name":"Mfsd14a","annotation":"Hippocampus abundant transcript 1 protein."},{"id":"ENSMUSP00000137736","abundance":0.632,"rank":12757,"name":"Gm26620","annotation":"Predicted gene, 26620."},{"id":"ENSMUSP00000033123","abundance":0.632,"rank":12758,"name":"Abcc8","annotation":"ATP-binding cassette, sub-family C (CFTR/MRP), member 8."},{"id":"ENSMUSP00000045566","abundance":0.632,"rank":12759,"name":"Rubcnl","annotation":"Protein associated with UVRAG as autophagy enhancer; Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (By similarity). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (By similarity). Bin [...] "},{"id":"ENSMUSP00000146006","abundance":0.632,"rank":12760,"name":"Zfp607a","annotation":"Zinc finger protein 607A."},{"id":"ENSMUSP00000026008","abundance":0.632,"rank":12761,"name":"Trim8","annotation":"Probable E3 ubiquitin-protein ligase TRIM8; Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000100013","abundance":0.631,"rank":12762,"name":"Sox4","annotation":"Transcription factor SOX-4; Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif."},{"id":"ENSMUSP00000051907","abundance":0.631,"rank":12763,"name":"Gas2l2","annotation":"GAS2-like protein 2; Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A. Regulates ciliary orientation and performance in cells located in the airway."},{"id":"ENSMUSP00000018066","abundance":0.631,"rank":12764,"name":"Prl3c1","annotation":"Prolactin-3C1; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000026499","abundance":0.631,"rank":12765,"name":"Crisp3","annotation":"Cysteine-rich secretory protein 3; This protein is supposed to help spermatozoa undergo functional maturation while they move from the testis to the ductus deferens; Belongs to the CRISP family."},{"id":"ENSMUSP00000048303","abundance":0.631,"rank":12766,"name":"Fcmr","annotation":"Fas apoptotic inhibitory molecule 3; May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation (By similarity)."},{"id":"ENSMUSP00000047505","abundance":0.631,"rank":12767,"name":"Smyd4","annotation":"SET and MYND domain-containing protein 4."},{"id":"ENSMUSP00000023356","abundance":0.631,"rank":12768,"name":"Snai2","annotation":"Zinc finger protein SNAI2; Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells. Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of [...] "},{"id":"ENSMUSP00000077584","abundance":0.631,"rank":12769,"name":"Rag1","annotation":"V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break  [...] "},{"id":"ENSMUSP00000140937","abundance":0.631,"rank":12770,"name":"Cacna1e","annotation":"Voltage-dependent R-type calcium channel subunit alpha-1E; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels conta [...] "},{"id":"ENSMUSP00000096514","abundance":0.63,"rank":12771,"name":"Dennd4b","annotation":"DENN domain-containing protein 4B; Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP- bound Rab proteins into their active GTP-bound form (By similarity)."},{"id":"ENSMUSP00000025666","abundance":0.63,"rank":12772,"name":"Slc22a19","annotation":"Solute carrier family 22 member 19; Sodium-independent organic anion transporter which shows high specificity for estrone sulfate, dehydroepiandrosterone sulfate, and the mycotoxin ochratoxin A (OTA). Transport of OTA is strongly inhibited by estrone sulfate and probenecid, and to a lesser extent by 2,4-dichlorophenoxyacetic acid (2,4-D) and salicylate. Transport of estrone sulfate is inhibited by various steroid sulfate conjugates including dehydroepiandrosterone sulfate, alpha-naphthyl sulfate, beta-estradiol sulfate, 4-methylumbelliferyl sulfate and p-nitrophenyl sulfate (but not mi [...] "},{"id":"ENSMUSP00000105714","abundance":0.63,"rank":12773,"name":"Fgd3","annotation":"FYVE, RhoGEF and PH domain-containing protein 3; Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape."},{"id":"ENSMUSP00000010248","abundance":0.63,"rank":12774,"name":"Tmem223","annotation":"Transmembrane protein 223."},{"id":"ENSMUSP00000113344","abundance":0.63,"rank":12775,"name":"Dzip3","annotation":"E3 ubiquitin-protein ligase DZIP3; E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA."},{"id":"ENSMUSP00000020362","abundance":0.63,"rank":12776,"name":"Kcnmb1","annotation":"Calcium-activated potassium channel subunit beta-1; Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its prese [...] "},{"id":"ENSMUSP00000137374","abundance":0.629,"rank":12777,"name":"Pou3f1","annotation":"POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis."},{"id":"ENSMUSP00000024650","abundance":0.629,"rank":12778,"name":"1700010I14Rik","annotation":"RIKEN cDNA 1700010I14 gene."},{"id":"ENSMUSP00000049759","abundance":0.629,"rank":12779,"name":"Tcaim","annotation":"T-cell activation inhibitor, mitochondrial; May regulate T-cell apoptosis."},{"id":"ENSMUSP00000074788","abundance":0.629,"rank":12780,"name":"Pdzd2","annotation":"PDZ domain-containing 2."},{"id":"ENSMUSP00000050039","abundance":0.629,"rank":12781,"name":"Lrfn4","annotation":"Leucine-rich repeat and fibronectin type-III domain-containing protein 4; Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery."},{"id":"ENSMUSP00000029469","abundance":0.629,"rank":12782,"name":"Reg4","annotation":"Regenerating islet-derived protein 4; Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium (By similarity)."},{"id":"ENSMUSP00000101518","abundance":0.629,"rank":12783,"name":"Fgf3","annotation":"Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal ear development (By similarity); Belongs to the heparin-binding growth factors family."},{"id":"ENSMUSP00000138387","abundance":0.629,"rank":12784,"name":"Mzf1","annotation":"Myeloid zinc finger 1."},{"id":"ENSMUSP00000091870","abundance":0.629,"rank":12785,"name":"Rgma","annotation":"Repulsive guidance molecule A; Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA- ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG- PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inacti [...] "},{"id":"ENSMUSP00000026902","abundance":0.629,"rank":12786,"name":"Rassf3","annotation":"Ras association domain-containing protein 3."},{"id":"ENSMUSP00000101209","abundance":0.628,"rank":12787,"name":"Acap3","annotation":"ArfGAP with coiled-coil, ankyrin repeat and PH domains 3."},{"id":"ENSMUSP00000133953","abundance":0.628,"rank":12788,"name":"Trim15","annotation":"Tripartite motif-containing 15."},{"id":"ENSMUSP00000034427","abundance":0.628,"rank":12789,"name":"Adat1","annotation":"tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA-Ala. Belongs to the ADAT1 family."},{"id":"ENSMUSP00000124581","abundance":0.628,"rank":12790,"name":"Clca3b","annotation":"Chloride channel accessory 3B."},{"id":"ENSMUSP00000143488","abundance":0.628,"rank":12791,"name":"Ift22","annotation":"Intraflagellar transport protein 22 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B."},{"id":"ENSMUSP00000097118","abundance":0.628,"rank":12792,"name":"Gm8765","annotation":"Predicted gene, EG667693."},{"id":"ENSMUSP00000024032","abundance":0.627,"rank":12793,"name":"9530002B09Rik","annotation":"RIKEN cDNA 9530002B09 gene."},{"id":"ENSMUSP00000073022","abundance":0.627,"rank":12794,"name":"Gsdma3","annotation":"Gasdermin-A3; May play a role in the transition from catagen to telogen at the end of hair follicle morphogenesis. May promote pyroptosis. Upon cleavage in vitro of genetically engineered Gsdma3, the released N-terminal moiety binds to membrane inner leaflet lipids, including bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate, as well as phosphatidylinositol (3,4,5)-bisphosphate, and more weakly to monophosphorylated phosphatidylinositols. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering p [...] "},{"id":"ENSMUSP00000097121","abundance":0.627,"rank":12795,"name":"Gm906","annotation":"Gene model 906, (NCBI)."},{"id":"ENSMUSP00000140002","abundance":0.627,"rank":12796,"name":"Msh3","annotation":"DNA mismatch repair protein Msh3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, a [...] "},{"id":"ENSMUSP00000056282","abundance":0.627,"rank":12797,"name":"Dpagt1","annotation":"UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol. Belongs to the glycosyltransferase 4 family."},{"id":"ENSMUSP00000038681","abundance":0.626,"rank":12798,"name":"Epg5","annotation":"Ectopic P granules protein 5 homolog; Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located."},{"id":"ENSMUSP00000144271","abundance":0.626,"rank":12799,"name":"Olfr519","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000103393","abundance":0.625,"rank":12800,"name":"Hemgn","annotation":"Hemogen; Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity)."},{"id":"ENSMUSP00000031384","abundance":0.625,"rank":12801,"name":"B3gnt4","annotation":"N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4; Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Has activity for type 2 oligosaccharides; Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000035583","abundance":0.625,"rank":12802,"name":"Ikzf5","annotation":"Zinc finger protein Pegasus; DNA-binding protein that binds to the 5'GNNTGTNG-3' core sequence. Transcriptional repressor (By similarity)."},{"id":"ENSMUSP00000109423","abundance":0.625,"rank":12803,"name":"Pja1","annotation":"E3 ubiquitin-protein ligase Praja-1; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome. May be involved in protein sorting."},{"id":"ENSMUSP00000032341","abundance":0.625,"rank":12804,"name":"Art4","annotation":"Ecto-ADP-ribosyltransferase 4; Belongs to the Arg-specific ADP-ribosyltransferase family."},{"id":"ENSMUSP00000112776","abundance":0.625,"rank":12805,"name":"Robo2","annotation":"Roundabout homolog 2; Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development."},{"id":"ENSMUSP00000062005","abundance":0.625,"rank":12806,"name":"Rnf182","annotation":"E3 ubiquitin-protein ligase RNF182; E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA."},{"id":"ENSMUSP00000000707","abundance":0.625,"rank":12807,"name":"Loxl3","annotation":"Lysyl oxidase homolog 3; Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross- links between collagens and elastin. Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ). Acts as a regulator of inflammatory response by inh [...] "},{"id":"ENSMUSP00000139611","abundance":0.624,"rank":12808,"name":"Gm28919","annotation":"Predicted gene 28919."},{"id":"ENSMUSP00000106931","abundance":0.624,"rank":12809,"name":"Dedd","annotation":"Death effector domain-containing protein; A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro."},{"id":"ENSMUSP00000149487","abundance":0.624,"rank":12810,"name":"Olfr1467","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000084599","abundance":0.624,"rank":12811,"name":"Kif20b","annotation":"Kinesin-like protein KIF20B; Plus-end-directed motor enzyme that is required for completion of cytokinesis (By similarity). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to t [...] "},{"id":"ENSMUSP00000021674","abundance":0.624,"rank":12812,"name":"Fos","annotation":"Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex, at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling (By similarity). Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and  [...] "},{"id":"ENSMUSP00000112019","abundance":0.624,"rank":12813,"name":"Tctex1d1","annotation":"Tctex1 domain-containing protein 1."},{"id":"ENSMUSP00000096898","abundance":0.624,"rank":12814,"name":"Poc5","annotation":"Centrosomal protein POC5; Essential for the assembly of the distal half of centrioles, required for centriole elongation."},{"id":"ENSMUSP00000000326","abundance":0.624,"rank":12815,"name":"Bcl6b","annotation":"B-cell CLL/lymphoma 6 member B protein; Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6."},{"id":"ENSMUSP00000105522","abundance":0.624,"rank":12816,"name":"Ninl","annotation":"Ninein-like protein; Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly (By similarity)."},{"id":"ENSMUSP00000024260","abundance":0.623,"rank":12817,"name":"Pcbp4","annotation":"Poly(rC)-binding protein 4; Single-stranded nucleic acid binding protein that binds preferentially to oligo dC."},{"id":"ENSMUSP00000062493","abundance":0.623,"rank":12818,"name":"E130308A19Rik","annotation":"RIKEN cDNA E130308A19 gene."},{"id":"ENSMUSP00000026076","abundance":0.623,"rank":12819,"name":"Gfra1","annotation":"GDNF family receptor alpha-1; Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor (By similarity)."},{"id":"ENSMUSP00000038181","abundance":0.623,"rank":12820,"name":"Kat6a","annotation":"Histone acetyltransferase KAT6A; Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2 (By similarity). Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML (By similarity)."},{"id":"ENSMUSP00000061107","abundance":0.623,"rank":12821,"name":"Synb","annotation":"Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties. Together with Syna, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. Synb is specifically involved in formation of syncytiotrophoblast layer II (SynT-II). Promotes myoblast fusion, and may play a role in regeneration of damaged muscle tissue in males. May have immunosuppressive activity."},{"id":"ENSMUSP00000139267","abundance":0.623,"rank":12822,"name":"Gm27179","annotation":"Predicted gene 27179."},{"id":"ENSMUSP00000107655","abundance":0.622,"rank":12823,"name":"Chn1","annotation":"N-chimaerin; GTPase-activating protein for p21-rac and a phorbol ester receptor. May play an important role in neuronal signal-transduction mechanisms (By similarity). Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance."},{"id":"ENSMUSP00000041789","abundance":0.622,"rank":12824,"name":"Slc26a7","annotation":"Anion exchange transporter; Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment- specific anion exchanger, specifically chloride. Plays a major role in gastric acid secretion. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family."},{"id":"ENSMUSP00000108825","abundance":0.622,"rank":12825,"name":"Lrsam1","annotation":"E3 ubiquitin-protein ligase LRSAM1; E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos (By similarity). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (By similarity). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (By similarity)."},{"id":"ENSMUSP00000045993","abundance":0.622,"rank":12826,"name":"Mycn","annotation":"N-myc proto-oncogene protein; Positively regulates the transcription of MYCNOS in neuroblastoma cells."},{"id":"ENSMUSP00000042816","abundance":0.622,"rank":12827,"name":"Rnf225","annotation":"RING finger protein 225."},{"id":"ENSMUSP00000032211","abundance":0.622,"rank":12828,"name":"Gdf3","annotation":"Growth/differentiation factor 3; Growth factor involved in early embryonic development and adipose-tissue homeostasis. During embryogenesis controls formation of anterior visceral endoderm and mesoderm and the establishment of anterior-posterior identity through a receptor complex comprising the receptor ACVR1B and the coreceptor TDGF1/Cripto. Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto. Belongs to the TGF-beta family."},{"id":"ENSMUSP00000027760","abundance":0.622,"rank":12829,"name":"Rgl1","annotation":"Ral guanine nucleotide dissociation stimulator-like 1; Probable guanine nucleotide exchange factor."},{"id":"ENSMUSP00000137154","abundance":0.622,"rank":12830,"name":"Tpbgl","annotation":"Trophoblast glycoprotein-like."},{"id":"ENSMUSP00000083892","abundance":0.621,"rank":12831,"name":"Plcxd1","annotation":"PI-PLC X domain-containing protein 1."},{"id":"ENSMUSP00000145018","abundance":0.621,"rank":12832,"name":"Smim4","annotation":"Small integral membrane protein 4; Belongs to the SMIM4 family."},{"id":"ENSMUSP00000041186","abundance":0.621,"rank":12833,"name":"Slc22a2","annotation":"Solute carrier family 22 member 2; Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamine, creatinine, amantadine, memantine, acriflavine, 4-[4- (dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4- phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as  [...] "},{"id":"ENSMUSP00000137972","abundance":0.621,"rank":12834,"name":"Tnfsf12","annotation":"Tumor necrosis factor ligand superfamily member 12, membrane form; Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion (By similarity); Belongs to the tumor necrosis factor family."},{"id":"ENSMUSP00000022620","abundance":0.621,"rank":12835,"name":"Chrna2","annotation":"Neuronal acetylcholine receptor subunit alpha-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane."},{"id":"ENSMUSP00000150106","abundance":0.62,"rank":12836,"name":"Olfr1359","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149423","abundance":0.62,"rank":12837,"name":"Olfr1360","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000021288","abundance":0.62,"rank":12838,"name":"Usp43","annotation":"Ubiquitin carboxyl-terminal hydrolase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)."},{"id":"ENSMUSP00000104150","abundance":0.62,"rank":12839,"name":"Wscd1","annotation":"WSC domain-containing protein 1; Belongs to the WSCD family."},{"id":"ENSMUSP00000086459","abundance":0.62,"rank":12840,"name":"Map3k4","annotation":"Mitogen-activated protein kinase kinase kinase 4; Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6."},{"id":"ENSMUSP00000089237","abundance":0.62,"rank":12841,"name":"Gpr31b","annotation":"12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor; High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B (By similarity)."},{"id":"ENSMUSP00000061754","abundance":0.62,"rank":12842,"name":"F2r","annotation":"Proteinase-activated receptor 1; High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis."},{"id":"ENSMUSP00000108655","abundance":0.62,"rank":12843,"name":"Cntrl","annotation":"Centriolin; Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission (By similarity)."},{"id":"ENSMUSP00000026383","abundance":0.62,"rank":12844,"name":"Gpr143","annotation":"G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport."},{"id":"ENSMUSP00000101416","abundance":0.62,"rank":12845,"name":"Clcnka","annotation":"Chloride channel protein ClC-Ka; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells; Belongs to the chloride channel (TC 2.A.49) family. CLCNKA subfamily."},{"id":"ENSMUSP00000154654","abundance":0.619,"rank":12846,"name":"Vmn1r188","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000023732","abundance":0.619,"rank":12847,"name":"Wnt10b","annotation":"Protein Wnt-10b; Member of the Wnt ligand gene family that encodes for secreted proteins, which activate the Wnt signaling cascade. Specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. Involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Acts in the immune system, mammary gland, adipose tissue, bone and skin; Belongs to the Wnt family."},{"id":"ENSMUSP00000159245","abundance":0.618,"rank":12848,"name":"ENSMUSP00000159245","annotation":"Odorant receptor 131-2-like."},{"id":"ENSMUSP00000115575","abundance":0.618,"rank":12849,"name":"Gm4969","annotation":"Predicted gene 4969."},{"id":"ENSMUSP00000086352","abundance":0.618,"rank":12850,"name":"Pkdrej","annotation":"Polycystic kidney disease and receptor for egg jelly-related protein; May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm; Belongs to the polycystin family."},{"id":"ENSMUSP00000019291","abundance":0.618,"rank":12851,"name":"Psg28","annotation":"Pregnancy-specific glycoprotein 28."},{"id":"ENSMUSP00000106809","abundance":0.618,"rank":12852,"name":"Efr3b","annotation":"Protein EFR3 homolog B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G- protein-coupled receptors; it is however unclear whether this role is direct or indirect."},{"id":"ENSMUSP00000134067","abundance":0.618,"rank":12853,"name":"Uncx","annotation":"Homeobox protein unc-4 homolog; Transcription factor involved in somitogenesis and neurogenesis. Required for the maintenance and differentiation of particular elements of the axial skeleton. May act upstream of PAX9. Plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and to deliver hormones for control of peripheral functions."},{"id":"ENSMUSP00000039188","abundance":0.618,"rank":12854,"name":"Slc25a34","annotation":"Solute carrier family 25 member 34; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000074104","abundance":0.617,"rank":12855,"name":"Prdm10","annotation":"PR domain zinc finger protein 10; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000119261","abundance":0.617,"rank":12856,"name":"Utp23","annotation":"rRNA-processing protein UTP23 homolog; Involved in rRNA-processing and ribosome biogenesis. Belongs to the UTP23/FCF1 family. UTP23 subfamily."},{"id":"ENSMUSP00000028689","abundance":0.617,"rank":12857,"name":"Lrp4","annotation":"Low-density lipoprotein receptor-related protein 4; Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the  [...] "},{"id":"ENSMUSP00000146101","abundance":0.617,"rank":12858,"name":"4930590J08Rik","annotation":"Uncharacterized protein C3orf20 homolog."},{"id":"ENSMUSP00000104825","abundance":0.617,"rank":12859,"name":"Ifi47","annotation":"Interferon-gamma-inducible GTPase Ifggc1 protein."},{"id":"ENSMUSP00000091219","abundance":0.616,"rank":12860,"name":"Csprs","annotation":"Component of Sp100-rs."},{"id":"ENSMUSP00000150546","abundance":0.616,"rank":12861,"name":"Olfr1084","annotation":"Olfactory receptor 1084."},{"id":"ENSMUSP00000128877","abundance":0.616,"rank":12862,"name":"Aadacl2fm2","annotation":"AADACL2 family member 2."},{"id":"ENSMUSP00000131904","abundance":0.616,"rank":12863,"name":"Fam102b","annotation":"Protein FAM102B; Belongs to the FAM102 family."},{"id":"ENSMUSP00000113274","abundance":0.616,"rank":12864,"name":"Arsk","annotation":"Arylsulfatase K."},{"id":"ENSMUSP00000024826","abundance":0.616,"rank":12865,"name":"Tff2","annotation":"Trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity)."},{"id":"ENSMUSP00000101938","abundance":0.616,"rank":12866,"name":"6030468B19Rik","annotation":"Protein IL-40; Probable B cell-associated cytokine that plays a role in the regulation of humoral immune responses. Involved in lymphocyte B cell development and immunoglobulin/IgA production."},{"id":"ENSMUSP00000031011","abundance":0.616,"rank":12867,"name":"Rab28","annotation":"Ras-related protein Rab-28."},{"id":"ENSMUSP00000140842","abundance":0.616,"rank":12868,"name":"Fam181a","annotation":"Family with sequence similarity 181, member A."},{"id":"ENSMUSP00000145529","abundance":0.615,"rank":12869,"name":"D6Ertd527e","annotation":"DNA segment, Chr 6, ERATO Doi 527,-expressed."},{"id":"ENSMUSP00000066977","abundance":0.615,"rank":12870,"name":"Rad54b","annotation":"DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group."},{"id":"ENSMUSP00000134205","abundance":0.614,"rank":12871,"name":"Jarid2","annotation":"Protein Jumonji; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, i [...] "},{"id":"ENSMUSP00000046368","abundance":0.614,"rank":12872,"name":"Tmtc4","annotation":"Protein O-mannosyl-transferase TMTC4; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3."},{"id":"ENSMUSP00000156151","abundance":0.614,"rank":12873,"name":"Ttc3","annotation":"E3 ubiquitin-protein ligase TTC3; E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains (By similarity). Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus (By similarity). Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation (By similarity). Positively regulates TGFB1-induced epithelial-mesenchymal  [...] "},{"id":"ENSMUSP00000136163","abundance":0.614,"rank":12874,"name":"Ankzf1","annotation":"Ankyrin repeat and zinc finger domain-containing protein 1; Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity)."},{"id":"ENSMUSP00000071966","abundance":0.614,"rank":12875,"name":"Plxnb1","annotation":"Plexin-B1; Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (By similarity). Plays a role in axon guidance, invasive growth and cell migration (By similarity)."},{"id":"ENSMUSP00000038229","abundance":0.614,"rank":12876,"name":"Kdm2b","annotation":"Lysine-specific demethylase 2B; Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri- methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (By similarity). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type  [...] "},{"id":"ENSMUSP00000099391","abundance":0.614,"rank":12877,"name":"Ptges3l","annotation":"Putative protein PTGES3L."},{"id":"ENSMUSP00000116779","abundance":0.613,"rank":12878,"name":"Fam131b","annotation":"Protein FAM131B."},{"id":"ENSMUSP00000000395","abundance":0.613,"rank":12879,"name":"Tmprss2","annotation":"Transmembrane protease serine 2 non-catalytic chain; Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions. The spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spik [...] "},{"id":"ENSMUSP00000072896","abundance":0.613,"rank":12880,"name":"Fastkd1","annotation":"FAST kinase domain-containing protein 1, mitochondrial; Involved in the down-regulation of mitochondrial MT-ND3 mRNA levels which leads to decreased respiratory complex I abundance and activity."},{"id":"ENSMUSP00000158015","abundance":0.612,"rank":12881,"name":"Vmn1r223","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000121679","abundance":0.612,"rank":12882,"name":"Naa30","annotation":"N-alpha-acetyltransferase 30; Catalytic subunit of the N-terminal acetyltransferase C (NatC) complex. Catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Leu-Ala and Met-Leu-Gly. Necessary for the lysosomal localization and function of ARL8B sugeesting that ARL8B is a NatC substrate."},{"id":"ENSMUSP00000054137","abundance":0.612,"rank":12883,"name":"Snx21","annotation":"Sorting nexin-21; Binds to membranes enriched in phosphatidylinositol 3- phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate. May be involved in several stages of intracellular trafficking; Belongs to the sorting nexin family."},{"id":"ENSMUSP00000018614","abundance":0.612,"rank":12884,"name":"Kcnab3","annotation":"Voltage-gated potassium channel subunit beta-3; Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv2.2 but not Kv2.1; Belongs to the shaker potassium channel beta subunit family."},{"id":"ENSMUSP00000154136","abundance":0.612,"rank":12885,"name":"Vmn1r220","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000152337","abundance":0.611,"rank":12886,"name":"Exoc3l4","annotation":"Exocyst complex component 3-like protein 4; Belongs to the SEC6 family."},{"id":"ENSMUSP00000025830","abundance":0.611,"rank":12887,"name":"Apba1","annotation":"Amyloid-beta A4 precursor protein-binding family A member 1; Putative function in synaptic vesicle exocytosis by binding to Munc18-1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of AAP-beta (By similarity)."},{"id":"ENSMUSP00000142159","abundance":0.611,"rank":12888,"name":"Pcdha8","annotation":"Protocadherin alpha 8."},{"id":"ENSMUSP00000078162","abundance":0.611,"rank":12889,"name":"Vmn2r10","annotation":"Vomeronasal 2, receptor 10."},{"id":"ENSMUSP00000148636","abundance":0.611,"rank":12890,"name":"Cfap54","annotation":"Cilia- and flagella-associated protein 54; Required for assembly and function of cilia and flagella."},{"id":"ENSMUSP00000098343","abundance":0.61,"rank":12891,"name":"Mansc4","annotation":"MANSC domain-containing protein 4."},{"id":"ENSMUSP00000032443","abundance":0.61,"rank":12892,"name":"Far2","annotation":"Fatty acyl-CoA reductase 2; Catalyzes the reduction of saturated but not unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. A lower activity can be observed with shorter fatty acyl-CoA substrates. It may play a role in the production of ether lipids/plasmalogens and wax monoesters which synthesis requires fatty alcohols as substrates (By similarity)."},{"id":"ENSMUSP00000100648","abundance":0.61,"rank":12893,"name":"Klhdc7a","annotation":"Kelch domain-containing protein 7A."},{"id":"ENSMUSP00000048576","abundance":0.61,"rank":12894,"name":"Grin3b","annotation":"Glutamate receptor ionotropic, NMDA 3B; NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3B/GRIN3B subfamily."},{"id":"ENSMUSP00000080548","abundance":0.61,"rank":12895,"name":"Tor4a","annotation":"Torsin-4A."},{"id":"ENSMUSP00000023006","abundance":0.609,"rank":12896,"name":"Lrrc6","annotation":"Protein tilB homolog; May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility; Belongs to the tilB family."},{"id":"ENSMUSP00000152603","abundance":0.609,"rank":12897,"name":"Sp4","annotation":"Transcription factor Sp4; Binds to GT and GC boxes promoters elements. Probable transcriptional activator. Required for normal male reproductive behavior."},{"id":"ENSMUSP00000092228","abundance":0.609,"rank":12898,"name":"Plekhg2","annotation":"Pleckstrin homology domain-containing family G member 2; May be a transforming oncogene with exchange activity for CDC42. May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide-binding protein (G protein) (By similarity). Involved in the regulation of actin polymerization (By similarity)."},{"id":"ENSMUSP00000137253","abundance":0.609,"rank":12899,"name":"Noc2l","annotation":"Nucleolar complex protein 2 homolog; Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis (By similarity)."},{"id":"ENSMUSP00000150607","abundance":0.609,"rank":12900,"name":"Olfr1209","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000153033","abundance":0.609,"rank":12901,"name":"Prl7d1","annotation":"Prolactin-7D1; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000114489","abundance":0.609,"rank":12902,"name":"Kctd9","annotation":"BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome."},{"id":"ENSMUSP00000054943","abundance":0.609,"rank":12903,"name":"Cep68","annotation":"Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase."},{"id":"ENSMUSP00000154549","abundance":0.609,"rank":12904,"name":"Vmn1r86","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000031291","abundance":0.608,"rank":12905,"name":"Asphd2","annotation":"Aspartate beta-hydroxylase domain-containing protein 2; May function as 2-oxoglutarate-dependent dioxygenase."},{"id":"ENSMUSP00000040037","abundance":0.608,"rank":12906,"name":"Usp31","annotation":"Ubiquitin-specific peptidase 31; Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000058941","abundance":0.607,"rank":12907,"name":"Edem3","annotation":"ER degradation-enhancing alpha-mannosidase-like protein 3; Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity. Belongs to the glycosyl hydrolase 47 family."},{"id":"ENSMUSP00000034700","abundance":0.607,"rank":12908,"name":"Yipf2","annotation":"Protein YIPF2; Belongs to the YIP1 family."},{"id":"ENSMUSP00000007296","abundance":0.607,"rank":12909,"name":"Pole","annotation":"DNA polymerase epsilon catalytic subunit A; Catalytic component of the DNA polymerase epsilon complex (By similarity). Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication (By similarity). It is also involved in DNA synthesis during DNA repair (By similarity). Belongs to the DNA polymerase type-B family."},{"id":"ENSMUSP00000149114","abundance":0.607,"rank":12910,"name":"Olfr611","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000104158","abundance":0.607,"rank":12911,"name":"Nlrp1a","annotation":"NACHT, LRR and PYD domains-containing protein 1a; As a potential sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB [...] "},{"id":"ENSMUSP00000052849","abundance":0.607,"rank":12912,"name":"Slc25a2","annotation":"Solute carrier family 25 (Mitochondrial carrier, Ornithine transporter) member 2; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000047730","abundance":0.607,"rank":12913,"name":"Sbspon","annotation":"Somatomedin-B and thrombospondin type-1 domain-containing protein."},{"id":"ENSMUSP00000074702","abundance":0.607,"rank":12914,"name":"Dsc2","annotation":"Desmocollin-2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms."},{"id":"ENSMUSP00000147914","abundance":0.606,"rank":12915,"name":"Olfr65","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000069246","abundance":0.606,"rank":12916,"name":"Rsbn1","annotation":"Lysine-specific demethylase 9; Histone demethylase that specifically demethylates dimethylated 'Lys-20' of histone H4 (H4K20me2), thereby modulating chromosome architecture; Belongs to the round spermatid basic protein 1 family."},{"id":"ENSMUSP00000126878","abundance":0.606,"rank":12917,"name":"Spsb3","annotation":"SPRY domain-containing SOCS box protein 3; May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins."},{"id":"ENSMUSP00000089979","abundance":0.605,"rank":12918,"name":"Plppr3","annotation":"Phospholipid phosphatase-related protein type 3."},{"id":"ENSMUSP00000034811","abundance":0.605,"rank":12919,"name":"Cyp19a1","annotation":"Aromatase; A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19- aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19 [...] "},{"id":"ENSMUSP00000049975","abundance":0.604,"rank":12920,"name":"Chst9","annotation":"Carbohydrate sulfotransferase 9; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Participates in biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures. Has a higher activity toward carbonic anhydrase VI than toward lutropin. Only active against terminal GalNAcbeta1,GalNAcbeta."},{"id":"ENSMUSP00000075327","abundance":0.604,"rank":12921,"name":"Ppp2r3a","annotation":"Protein phosphatase 2, regulatory subunit B'', alpha."},{"id":"ENSMUSP00000034361","abundance":0.604,"rank":12922,"name":"D230025D16Rik","annotation":"UPF0183 protein C16orf70 homolog; Belongs to the UPF0183 family."},{"id":"ENSMUSP00000036438","abundance":0.603,"rank":12923,"name":"Tjp3","annotation":"Tight junction protein ZO-3; Tjp1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PatJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (By simi [...] "},{"id":"ENSMUSP00000109363","abundance":0.603,"rank":12924,"name":"Zbtb21","annotation":"Zinc finger and BTB domain-containing 21."},{"id":"ENSMUSP00000033500","abundance":0.603,"rank":12925,"name":"Eras","annotation":"GTPase ERas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells."},{"id":"ENSMUSP00000099810","abundance":0.603,"rank":12926,"name":"Arnt","annotation":"Aryl hydrocarbon receptor nuclear translocator; Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens (By similarity). The heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters and functions as a transcriptional regulator of the adaptive response to hypoxia. The heterodimer ARNT:AHR binds to core DNA sequ [...] "},{"id":"ENSMUSP00000017590","abundance":0.603,"rank":12927,"name":"C1qtnf1","annotation":"Complement C1q tumor necrosis factor-related protein 1."},{"id":"ENSMUSP00000025003","abundance":0.603,"rank":12928,"name":"Sox8","annotation":"Transcription factor SOX-8; May play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'."},{"id":"ENSMUSP00000139037","abundance":0.602,"rank":12929,"name":"Wnk3","annotation":"Serine/threonine-protein kinase WNK3; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A1, SLC12A2, SLC12A3, SCNN1A, SCNN1B, SCNN1D and SGK1. Inhibits SLC12A4, SLC12A5, SLC12A6 and SLC12A7. Phosphorylates WNK4. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase- dependent pathway. Inhi [...] "},{"id":"ENSMUSP00000027186","abundance":0.602,"rank":12930,"name":"Trak2","annotation":"Trafficking protein, kinesin-binding 2."},{"id":"ENSMUSP00000026377","abundance":0.602,"rank":12931,"name":"Padi3","annotation":"Protein-arginine deiminase type-3; Catalyzes the deimination of arginine residues of proteins. Belongs to the protein arginine deiminase family."},{"id":"ENSMUSP00000112135","abundance":0.601,"rank":12932,"name":"Zkscan3","annotation":"Zinc finger protein with KRAB and SCAN domains 3; Transcriptional factor that binds to the consensus sequence 5'-[GT][AG][AGT]GGGG-3' and acts as a repressor of autophagy. Specifically represses expression of genes involved in autophagy and lysosome biogenesis/function such as MAP1LC3B, ULK1 or WIPI2. Associates with chromatin at the ITGB4 and VEGF promoters (By similarity)."},{"id":"ENSMUSP00000084282","abundance":0.601,"rank":12933,"name":"Col4a4","annotation":"Collagen alpha-4(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen."},{"id":"ENSMUSP00000073041","abundance":0.601,"rank":12934,"name":"Foxm1","annotation":"Forkhead box protein M1; Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response."},{"id":"ENSMUSP00000035726","abundance":0.601,"rank":12935,"name":"Rgl3","annotation":"Ral guanine nucleotide dissociation stimulator-like 3; Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1."},{"id":"ENSMUSP00000034944","abundance":0.601,"rank":12936,"name":"Dapk2","annotation":"Death-associated protein kinase 2; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Capable of regulating both type I apoptotic and type II autophagic cell death signals. The former involves caspase activation, chromatin and mitochondrial condensation while the latter involves caspase-independent cell death in conjunction with accumulation of mature autophagic vesicles, plasma membrane blebs, and nuclear condensation without DNA degradation. Mediator of anoikis and a suppressor of [...] "},{"id":"ENSMUSP00000065278","abundance":0.6,"rank":12937,"name":"P3h4","annotation":"Endoplasmic reticulum protein SC65; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly."},{"id":"ENSMUSP00000045384","abundance":0.6,"rank":12938,"name":"Shfl","annotation":"Shiftless antiviral inhibitor of ribosomal frameshifting protein homolog; Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses and cellular genes. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site. May exhibit antiviral activity; Belongs to the SHFL family."},{"id":"ENSMUSP00000054234","abundance":0.6,"rank":12939,"name":"Brd8dc","annotation":"BRD8 domain-containing."},{"id":"ENSMUSP00000108784","abundance":0.6,"rank":12940,"name":"Prame","annotation":"Preferentially-expressed antigen in melanoma."},{"id":"ENSMUSP00000099865","abundance":0.6,"rank":12941,"name":"Tenm2","annotation":"Ten-2 intracellular domain; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 receptor. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity)."},{"id":"ENSMUSP00000066543","abundance":0.6,"rank":12942,"name":"Gabre","annotation":"Gamma-aminobutyric acid (GABA) A receptor, subunit epsilon; Belongs to the ligand-gated ion channel (TC 1.A.9) family."},{"id":"ENSMUSP00000044660","abundance":0.6,"rank":12943,"name":"Cacna2d4","annotation":"Voltage-dependent calcium channel subunit alpha-2/delta-4; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel."},{"id":"ENSMUSP00000150545","abundance":0.6,"rank":12944,"name":"Olfr984","annotation":"Olfactory receptor MOR239-6."},{"id":"ENSMUSP00000145343","abundance":0.6,"rank":12945,"name":"E330021D16Rik","annotation":"RIKEN cDNA E330021D16 gene."},{"id":"ENSMUSP00000133935","abundance":0.6,"rank":12946,"name":"Gcnt1","annotation":"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O-glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes."},{"id":"ENSMUSP00000147298","abundance":0.6,"rank":12947,"name":"Zbtb45","annotation":"Zinc finger and BTB domain-containing protein 45; May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation."},{"id":"ENSMUSP00000030489","abundance":0.6,"rank":12948,"name":"Tal1","annotation":"T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation."},{"id":"ENSMUSP00000137246","abundance":0.6,"rank":12949,"name":"Tmem200c","annotation":"Transmembrane protein 200C."},{"id":"ENSMUSP00000053700","abundance":0.599,"rank":12950,"name":"Tas2r118","annotation":"Taste receptor type 2 member 16; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)."},{"id":"ENSMUSP00000115260","abundance":0.599,"rank":12951,"name":"Adad1","annotation":"Adenosine deaminase domain-containing protein 1; Plays a role in spermatogenesis. Binds to RNA but not to DNA."},{"id":"ENSMUSP00000049912","abundance":0.599,"rank":12952,"name":"Ccdc60","annotation":"Coiled-coil domain-containing protein 60."},{"id":"ENSMUSP00000050972","abundance":0.599,"rank":12953,"name":"Crebzf","annotation":"CREB/ATF bZIP transcription factor; Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells (By similarity). Belongs to the bZIP family. ATF subfamily."},{"id":"ENSMUSP00000060437","abundance":0.599,"rank":12954,"name":"Upp2","annotation":"Uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)."},{"id":"ENSMUSP00000063650","abundance":0.598,"rank":12955,"name":"Dcdc2a","annotation":"Doublecortin domain-containing protein 2; Protein that plays a role in the inhibition of canonical Wnt signaling pathway (By similarity). May be involved in neuronal migration during development of the cerebral neocortex (By similarity). Involved in the control of ciliogenesis and ciliary length (By similarity)."},{"id":"ENSMUSP00000142274","abundance":0.598,"rank":12956,"name":"Gm37388","annotation":"Predicted gene, 37388."},{"id":"ENSMUSP00000101908","abundance":0.598,"rank":12957,"name":"Scmh1","annotation":"Polycomb protein SCMH1; Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes; Belongs to the SCM family."},{"id":"ENSMUSP00000057223","abundance":0.598,"rank":12958,"name":"Tigd2","annotation":"Tigger transposable element-derived protein 2."},{"id":"ENSMUSP00000020704","abundance":0.598,"rank":12959,"name":"Igfbp1","annotation":"Insulin-like growth factor-binding protein 1; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity)."},{"id":"ENSMUSP00000057005","abundance":0.598,"rank":12960,"name":"Lrrn4","annotation":"Leucine-rich repeat neuronal protein 4; May play an important role in hippocampus-dependent long- lasting memory."},{"id":"ENSMUSP00000079900","abundance":0.598,"rank":12961,"name":"Myt1","annotation":"Myelin transcription factor 1; Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage development by modulating oligodendrocyte progenitor proliferation relative to terminal differentiation and up-regulation of myelin gene transcription (By similarity)."},{"id":"ENSMUSP00000091470","abundance":0.596,"rank":12962,"name":"Gsdma2","annotation":"Gasdermin-A2; May promote pyroptosis. Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity. The physiological relevance of these observations is unknown."},{"id":"ENSMUSP00000047697","abundance":0.596,"rank":12963,"name":"Syne2","annotation":"Nesprin-2; Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane acti [...] "},{"id":"ENSMUSP00000103998","abundance":0.596,"rank":12964,"name":"Gm9733","annotation":"SIRP beta 1 like 2 protein."},{"id":"ENSMUSP00000032151","abundance":0.595,"rank":12965,"name":"Eif4e3","annotation":"Eukaryotic translation initiation factor 4E type 3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis. May act as an inhibitor of EIF4E1 activity."},{"id":"ENSMUSP00000136181","abundance":0.595,"rank":12966,"name":"Plscr5","annotation":"Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family."},{"id":"ENSMUSP00000119891","abundance":0.595,"rank":12967,"name":"Cdk5rap2","annotation":"CDK5 regulatory subunit-associated protein 2; Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis. Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, doe [...] "},{"id":"ENSMUSP00000022830","abundance":0.595,"rank":12968,"name":"Ripk3","annotation":"Receptor-interacting serine/threonine-protein kinase 3; Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production."},{"id":"ENSMUSP00000006221","abundance":0.594,"rank":12969,"name":"Vps54","annotation":"Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling."},{"id":"ENSMUSP00000000171","abundance":0.594,"rank":12970,"name":"Pih1d2","annotation":"PIH1 domain-containing protein 2."},{"id":"ENSMUSP00000159200","abundance":0.593,"rank":12971,"name":"Gm7609","annotation":"Predicted pseudogene 7609."},{"id":"ENSMUSP00000139412","abundance":0.593,"rank":12972,"name":"Dydc1","annotation":"DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis."},{"id":"ENSMUSP00000092735","abundance":0.593,"rank":12973,"name":"Mamdc4","annotation":"Apical endosomal glycoprotein; Probably involved in the sorting and selective transport of receptors and ligands across polarized epithelia."},{"id":"ENSMUSP00000154268","abundance":0.593,"rank":12974,"name":"Mill2","annotation":"MHC I-like leukocyte 2 long form; Belongs to the MHC class I family."},{"id":"ENSMUSP00000079851","abundance":0.593,"rank":12975,"name":"Cenpi","annotation":"Centromere protein I; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle- stimulating hormone (By similarity); Belongs to the CENP-I/CTF3 family."},{"id":"ENSMUSP00000073751","abundance":0.593,"rank":12976,"name":"Prom1","annotation":"Prominin-1; May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner."},{"id":"ENSMUSP00000072286","abundance":0.592,"rank":12977,"name":"Zfp809","annotation":"Zinc finger protein 809; Transcription factor specifically required to repress retrotransposons in embryonic stem cells. Recognizes and binds retroviral DNA sequences from a large subset of mammalian retroviruses and retroelements and repress their expression by recruiting a repressive complex containing TRIM28/KAP1."},{"id":"ENSMUSP00000128314","abundance":0.592,"rank":12978,"name":"Ppfia4","annotation":"Liprin-alpha 4."},{"id":"ENSMUSP00000025237","abundance":0.591,"rank":12979,"name":"Tslp","annotation":"Thymic stromal lymphopoietin; Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c(+) dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity)."},{"id":"ENSMUSP00000041581","abundance":0.591,"rank":12980,"name":"March9","annotation":"E3 ubiquitin-protein ligase MARCHF9; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates."},{"id":"ENSMUSP00000002466","abundance":0.591,"rank":12981,"name":"Nr2f6","annotation":"Nuclear receptor subfamily 2 group F member 6; Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin- choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine- dependent and -independent transcripti [...] "},{"id":"ENSMUSP00000030289","abundance":0.591,"rank":12982,"name":"Usp1","annotation":"Ubiquitin carboxyl-terminal hydrolase 1; Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA- mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000074978","abundance":0.59,"rank":12983,"name":"Mcm9","annotation":"DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross- links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50- NBN/NBS1 (MRN) complex at double-stranded DNA breaks to generate ssDNA by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (By similarity). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs a [...] "},{"id":"ENSMUSP00000107297","abundance":0.589,"rank":12984,"name":"Camkk2","annotation":"Calcium/calmodulin-dependent protein kinase kinase 2; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK4 and CAMK1D (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branchin [...] "},{"id":"ENSMUSP00000107451","abundance":0.589,"rank":12985,"name":"Tmppe","annotation":"Transmembrane protein with metallophosphoesterase domain."},{"id":"ENSMUSP00000099473","abundance":0.589,"rank":12986,"name":"Adra1d","annotation":"Alpha-1D adrenergic receptor; This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium."},{"id":"ENSMUSP00000050727","abundance":0.589,"rank":12987,"name":"Adam24","annotation":"Disintegrin and metalloproteinase domain-containing protein 24; Plasma membrane protease present on mature sperm that may be involved in sperm function during epididymal maturation and/or fertilization."},{"id":"ENSMUSP00000031739","abundance":0.589,"rank":12988,"name":"Ppp1r35","annotation":"Protein phosphatase 1 regulatory subunit 35; Inhibits PPP1CA phosphatase activity; Belongs to the PPP1R35 family."},{"id":"ENSMUSP00000037036","abundance":0.588,"rank":12989,"name":"Ceacam10","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 10; May interact with other CEACAM proteins on the sperm surface. Belongs to the immunoglobulin superfamily. CEA family."},{"id":"ENSMUSP00000094449","abundance":0.588,"rank":12990,"name":"Il22","annotation":"Interleukin-22; Cytokine that contributes to the inflammatory response in vivo; Belongs to the IL-10 family."},{"id":"ENSMUSP00000088837","abundance":0.588,"rank":12991,"name":"Insr","annotation":"Insulin receptor subunit alpha; Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lea [...] "},{"id":"ENSMUSP00000120547","abundance":0.588,"rank":12992,"name":"Eri2","annotation":"ERI1 exoribonuclease 2."},{"id":"ENSMUSP00000154746","abundance":0.588,"rank":12993,"name":"Vmn1r74","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000144040","abundance":0.588,"rank":12994,"name":"Plb1","annotation":"Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids (By similarity). Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily."},{"id":"ENSMUSP00000075876","abundance":0.588,"rank":12995,"name":"Tas2r138","annotation":"Taste receptor type 2 member 38; Putative taste receptor which may play a role in the perception of bitterness; Belongs to the G-protein coupled receptor T2R family."},{"id":"ENSMUSP00000081947","abundance":0.587,"rank":12996,"name":"Gxylt1","annotation":"Glucoside xylosyltransferase 1; Glycosyltransferase which elongates the O-linked glucose attached to EGF-like repeats in the extracellular domain of Notch proteins by catalyzing the addition of xylose."},{"id":"ENSMUSP00000045432","abundance":0.587,"rank":12997,"name":"Mamdc2","annotation":"MAM domain-containing protein 2."},{"id":"ENSMUSP00000030376","abundance":0.587,"rank":12998,"name":"Kcnq4","annotation":"Potassium voltage-gated channel subfamily KQT member 4; Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea; Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily."},{"id":"ENSMUSP00000152323","abundance":0.587,"rank":12999,"name":"Prxl2c","annotation":"Peroxiredoxin-like 2C; May regulate positively ERK1/2 signaling and AKT1 activation leading to HIF1A up-regulation with an increased expression of glycolysis genes and enhanced glycolysis."},{"id":"ENSMUSP00000092021","abundance":0.587,"rank":13000,"name":"Wscd2","annotation":"WSC domain-containing protein 2."},{"id":"ENSMUSP00000136430","abundance":0.586,"rank":13001,"name":"Tex44","annotation":"Testis-expressed protein 44."},{"id":"ENSMUSP00000032732","abundance":0.586,"rank":13002,"name":"Apba2","annotation":"Amyloid-beta A4 precursor protein-binding family A member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence formation of APP-beta."},{"id":"ENSMUSP00000102976","abundance":0.586,"rank":13003,"name":"Zfp592","annotation":"Zinc finger protein 592; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000052185","abundance":0.586,"rank":13004,"name":"Gpr37","annotation":"Prosaposin receptor GPR37; Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity)."},{"id":"ENSMUSP00000149907","abundance":0.586,"rank":13005,"name":"Olfr837","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000028846","abundance":0.586,"rank":13006,"name":"Dusp2","annotation":"Dual specificity protein phosphatase 2; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2."},{"id":"ENSMUSP00000029948","abundance":0.585,"rank":13007,"name":"Bmpr1b","annotation":"Bone morphogenetic protein receptor type-1B; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction."},{"id":"ENSMUSP00000140615","abundance":0.585,"rank":13008,"name":"Slc35a4","annotation":"Probable UDP-sugar transporter protein SLC35A4."},{"id":"ENSMUSP00000002180","abundance":0.585,"rank":13009,"name":"Spi1","annotation":"Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing."},{"id":"ENSMUSP00000153150","abundance":0.585,"rank":13010,"name":"4833420G17Rik","annotation":"Uncharacterized protein C5orf34 homolog."},{"id":"ENSMUSP00000035379","abundance":0.585,"rank":13011,"name":"Ints6l","annotation":"Integrator complex subunit 6-like."},{"id":"ENSMUSP00000117336","abundance":0.584,"rank":13012,"name":"Sgms1","annotation":"Phosphatidylcholine:ceramide cholinephosphotransferase 1; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell  [...] "},{"id":"ENSMUSP00000158585","abundance":0.584,"rank":13013,"name":"Btbd35f1","annotation":"BTB domain containing 35, family member 1."},{"id":"ENSMUSP00000058300","abundance":0.584,"rank":13014,"name":"Zfp119b","annotation":"Zinc finger protein 119b."},{"id":"ENSMUSP00000052174","abundance":0.584,"rank":13015,"name":"Olfm5","annotation":"Olfactomedin 5."},{"id":"ENSMUSP00000060255","abundance":0.584,"rank":13016,"name":"Zfp831","annotation":"Zinc finger protein 831."},{"id":"ENSMUSP00000024155","abundance":0.584,"rank":13017,"name":"Kcnk16","annotation":"Potassium channel, subfamily K, member 16; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family."},{"id":"ENSMUSP00000028905","abundance":0.584,"rank":13018,"name":"Pcsk2","annotation":"Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity)."},{"id":"ENSMUSP00000029482","abundance":0.584,"rank":13019,"name":"Gpsm2","annotation":"G-protein-signaling modulator 2; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity. Belongs to the GPSM family."},{"id":"ENSMUSP00000033804","abundance":0.583,"rank":13020,"name":"Zcchc18","annotation":"Zinc finger CCHC domain-containing protein 18; Belongs to the ZCCHC12 family."},{"id":"ENSMUSP00000038922","abundance":0.583,"rank":13021,"name":"Nipal2","annotation":"NIPA-like protein 2."},{"id":"ENSMUSP00000149035","abundance":0.583,"rank":13022,"name":"Olfr235","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000038015","abundance":0.583,"rank":13023,"name":"Frem3","annotation":"FRAS1-related extracellular matrix protein 3; Extracellular matrix protein which may play a role in cell adhesion."},{"id":"ENSMUSP00000044637","abundance":0.582,"rank":13024,"name":"Asb11","annotation":"Ankyrin repeat and SOCS box protein 11; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family."},{"id":"ENSMUSP00000080643","abundance":0.582,"rank":13025,"name":"Dzank1","annotation":"Double zinc ribbon and ankyrin repeat-containing protein 1."},{"id":"ENSMUSP00000043896","abundance":0.582,"rank":13026,"name":"Chtf18","annotation":"Chromosome transmission fidelity protein 18 homolog; Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP- depen [...] "},{"id":"ENSMUSP00000025224","abundance":0.581,"rank":13027,"name":"Gfra3","annotation":"GDNF family receptor alpha-3; Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase (By similarity)."},{"id":"ENSMUSP00000085175","abundance":0.581,"rank":13028,"name":"Uprt","annotation":"Uracil phosphoribosyltransferase homolog."},{"id":"ENSMUSP00000028337","abundance":0.581,"rank":13029,"name":"Lrrc26","annotation":"Leucine-rich repeat-containing protein 26; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium (By similarity)."},{"id":"ENSMUSP00000067200","abundance":0.581,"rank":13030,"name":"Snupn","annotation":"Snurportin-1; Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs."},{"id":"ENSMUSP00000033418","abundance":0.581,"rank":13031,"name":"Il13ra1","annotation":"Interleukin-13 receptor subunit alpha-1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity (By similarity); Belongs to the type I cytokine receptor family. Type 5 subfamily."},{"id":"ENSMUSP00000130949","abundance":0.581,"rank":13032,"name":"Otog","annotation":"Otogelin; Glycoprotein specific to acellular membranes of the inner ear. May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule. May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea. May play a role in mechanotransduction processes."},{"id":"ENSMUSP00000034534","abundance":0.581,"rank":13033,"name":"Ets1","annotation":"Protein C-ets-1; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity)."},{"id":"ENSMUSP00000033957","abundance":0.58,"rank":13034,"name":"Adam18","annotation":"Disintegrin and metalloproteinase domain-containing protein 18; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein."},{"id":"ENSMUSP00000099969","abundance":0.58,"rank":13035,"name":"Pakap-2","annotation":"Paralemmin-2."},{"id":"ENSMUSP00000067181","abundance":0.58,"rank":13036,"name":"Aatk","annotation":"Serine/threonine-protein kinase LMTK1; May be involved in neuronal differentiation; Belongs to the protein kinase superfamily. Tyr protein kinase family."},{"id":"ENSMUSP00000043410","abundance":0.58,"rank":13037,"name":"2410131K14Rik","annotation":"UPF0454 protein C12orf49 homolog."},{"id":"ENSMUSP00000079038","abundance":0.58,"rank":13038,"name":"Tmem117","annotation":"Transmembrane protein 117; Involved in endoplasmic reticulum (ER) stress-induced cell death pathway; Belongs to the TMEM117 family."},{"id":"ENSMUSP00000106667","abundance":0.579,"rank":13039,"name":"Epo","annotation":"Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3."},{"id":"ENSMUSP00000139602","abundance":0.579,"rank":13040,"name":"Gm28510","annotation":"Predicted gene 28510."},{"id":"ENSMUSP00000031345","abundance":0.579,"rank":13041,"name":"Rchy1","annotation":"RING finger and CHY zinc finger domain-containing protein 1; Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, P73, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Monoubiquitinates the translesion DNA polymerase POLH (By similarity). Contributes to the regulation of the cell cycle progression."},{"id":"ENSMUSP00000039699","abundance":0.579,"rank":13042,"name":"Muc5ac","annotation":"Mucin 5, subtypes A and C, tracheobronchial/gastric."},{"id":"ENSMUSP00000101431","abundance":0.579,"rank":13043,"name":"Gm13030","annotation":"Predicted gene 13030."},{"id":"ENSMUSP00000029696","abundance":0.579,"rank":13044,"name":"Khdc4","annotation":"KH homology domain-containing protein 4; RNA-binding protein involved in pre-mRNA splicing. Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome. Involved in regulating splice site selection. Binds preferentially RNA with A/C rich sequences and poly-C stretches."},{"id":"ENSMUSP00000150151","abundance":0.579,"rank":13045,"name":"Olfr767","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000107978","abundance":0.578,"rank":13046,"name":"Hps4","annotation":"Hermansky-Pudlak syndrome 4 protein homolog; Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38."},{"id":"ENSMUSP00000063051","abundance":0.578,"rank":13047,"name":"Tspyl1","annotation":"Testis-specific Y-encoded-like protein 1."},{"id":"ENSMUSP00000059894","abundance":0.578,"rank":13048,"name":"Mtmr9","annotation":"Myotubularin-related protein 9; Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels (By similarity). Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol  [...] "},{"id":"ENSMUSP00000150725","abundance":0.578,"rank":13049,"name":"Olfr765","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000022242","abundance":0.578,"rank":13050,"name":"Emb","annotation":"Embigin; Plays a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates."},{"id":"ENSMUSP00000044983","abundance":0.578,"rank":13051,"name":"Hand2","annotation":"Heart- and neural crest derivatives-expressed protein 2; Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior- posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the he [...] "},{"id":"ENSMUSP00000076729","abundance":0.577,"rank":13052,"name":"Mab21l2","annotation":"Protein mab-21-like 2; Required for several aspects of embryonic development including normal development of the eye, notochord, neural tube and other organ tissues, and for embryonic turning. Belongs to the mab-21 family."},{"id":"ENSMUSP00000108235","abundance":0.577,"rank":13053,"name":"Galnt5","annotation":"Polypeptide N-acetylgalactosaminyltransferase 5; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2 or Muc1b substrates (By similarity); Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily."},{"id":"ENSMUSP00000002683","abundance":0.577,"rank":13054,"name":"Ccdc97","annotation":"Coiled-coil domain-containing protein 97."},{"id":"ENSMUSP00000089075","abundance":0.577,"rank":13055,"name":"Zdhhc11","annotation":"Probable palmitoyltransferase ZDHHC11."},{"id":"ENSMUSP00000063474","abundance":0.576,"rank":13056,"name":"1700013H16Rik","annotation":"RIKEN cDNA 1700013H16 gene."},{"id":"ENSMUSP00000069636","abundance":0.576,"rank":13057,"name":"Acot11","annotation":"Acyl-coenzyme A thioesterase 11; Has an acyl-CoA thioesterase activity with a preference for the long chain fatty acyl-CoA thioesters hexadecanoyl-CoA/palmitoyl-CoA and tetradecanoyl-CoA/myristoyl-CoA which are the main substrates in the mitochondrial beta-oxidation pathway."},{"id":"ENSMUSP00000069255","abundance":0.576,"rank":13058,"name":"Smpd3","annotation":"Sphingomyelin phosphodiesterase 3; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Acts as a regulator of postnatal development and participates in bone and dentin mineralization. Overexpression enhances cell death, suggesting that it may be involved in apoptosis control. Belongs to the n [...] "},{"id":"ENSMUSP00000143939","abundance":0.575,"rank":13059,"name":"Clock","annotation":"Circadian locomoter output cycles protein kaput; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine,  [...] "},{"id":"ENSMUSP00000159137","abundance":0.575,"rank":13060,"name":"Fgfbp3","annotation":"Fibroblast growth factor-binding protein 3; Heparin-binding protein which binds to FGF2, prevents binding of FGF2 to heparin and probably inhibits immobilization of FGF2 on extracellular matrix glycosaminoglycans, allowing its release and subsequent activation of FGFR signaling which leads to increased vascular permeability; Belongs to the fibroblast growth factor-binding protein family."},{"id":"ENSMUSP00000055208","abundance":0.575,"rank":13061,"name":"Tmem161b","annotation":"Transmembrane protein 161B."},{"id":"ENSMUSP00000100524","abundance":0.575,"rank":13062,"name":"Zxdb","annotation":"Zinc finger X-linked protein ZXDB; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes."},{"id":"ENSMUSP00000026553","abundance":0.575,"rank":13063,"name":"Syce1","annotation":"Synaptonemal complex central element protein 1; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. Belongs to the SYCE family."},{"id":"ENSMUSP00000030145","abundance":0.575,"rank":13064,"name":"Dcaf12","annotation":"DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF12 family."},{"id":"ENSMUSP00000035376","abundance":0.574,"rank":13065,"name":"4930447C04Rik","annotation":"Protein SIX6OS1; Meiotic protein that localizes to the central element of the synaptonemal complex and is required for chromosome synapsis during meiotic recombination. Required for the appropriate processing of intermediate recombination nodules before crossover formation."},{"id":"ENSMUSP00000147447","abundance":0.574,"rank":13066,"name":"Pkhd1l1","annotation":"Fibrocystin-L."},{"id":"ENSMUSP00000032315","abundance":0.574,"rank":13067,"name":"Tas2r116","annotation":"Taste receptor type 2 member 116; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000047164","abundance":0.574,"rank":13068,"name":"Capn8","annotation":"Calpain-8; Calcium-regulated non-lysosomal thiol-protease (By similarity). Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta-subunit of coatomer complex."},{"id":"ENSMUSP00000053361","abundance":0.574,"rank":13069,"name":"Emx2","annotation":"Homeobox protein EMX2; Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system."},{"id":"ENSMUSP00000153013","abundance":0.574,"rank":13070,"name":"Cenpj","annotation":"Centromere protein J; Plays an important role in cell division and centrosome function by participating in centriole duplication. Inhibits microtubule nucleation from the centrosome. Involved in the regulation of slow processive growth of centriolar microtubules. Acts as microtubule plus-end tracking protein that stabilizes centriolar microtubules and inhibits microtubule polymerization and extension from the distal ends of centrioles. Required for centriole elongation and for STIL-mediated centriole amplification. Required for the recruitment of CEP295 to the proximal end of new-born  [...] "},{"id":"ENSMUSP00000123506","abundance":0.574,"rank":13071,"name":"Flt3l","annotation":"Fms-related tyrosine kinase 3 ligand; Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins."},{"id":"ENSMUSP00000023616","abundance":0.574,"rank":13072,"name":"Slc15a2","annotation":"Solute carrier family 15 member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil (By similarity); Belongs to the PTR2/POT transporter (TC 2.A.17) family."},{"id":"ENSMUSP00000149807","abundance":0.573,"rank":13073,"name":"Olfr733","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000041874","abundance":0.573,"rank":13074,"name":"Egln3","annotation":"Egl nine homolog 3; Plays a crucial role in DNA damage response (DDR) by hydroxylating TELO2, promoting its interaction with ATR which is required for activation of the ATR/CHK1/p53 pathway (By similarity). Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both  [...] "},{"id":"ENSMUSP00000132187","abundance":0.573,"rank":13075,"name":"Gm38392","annotation":"Predicted gene, 38392."},{"id":"ENSMUSP00000149170","abundance":0.573,"rank":13076,"name":"Olfr398","annotation":"Olfactory receptor MOR157-1."},{"id":"ENSMUSP00000024572","abundance":0.573,"rank":13077,"name":"Rsph3b","annotation":"Radial spoke head protein 3 homolog B; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity)."},{"id":"ENSMUSP00000101150","abundance":0.572,"rank":13078,"name":"Col10a1","annotation":"Collagen alpha-1(X) chain; Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage."},{"id":"ENSMUSP00000038138","abundance":0.572,"rank":13079,"name":"Kdm5b","annotation":"Lysine-specific demethylase 5B; Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2."},{"id":"ENSMUSP00000059643","abundance":0.572,"rank":13080,"name":"Klhl31","annotation":"Kelch-like protein 31; Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE) (By similarity)."},{"id":"ENSMUSP00000048929","abundance":0.572,"rank":13081,"name":"Aox4","annotation":"Aldehyde oxidase 4; Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all-trans- retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles. Belongs to the xanthine dehydrogenase family."},{"id":"ENSMUSP00000048904","abundance":0.572,"rank":13082,"name":"Hsf4","annotation":"Heat shock factor protein 4; DNA-binding protein that specifically binds heat shock promoter elements (HSE). The HSF4A isoform represses transcription while the HSF4B isoform activates transcription."},{"id":"ENSMUSP00000001179","abundance":0.572,"rank":13083,"name":"Pcnt","annotation":"Pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome."},{"id":"ENSMUSP00000130152","abundance":0.572,"rank":13084,"name":"Prr5l","annotation":"Proline-rich protein 5-like; Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (By similarity). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF-alpha and GM- CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response [...] "},{"id":"ENSMUSP00000135787","abundance":0.572,"rank":13085,"name":"Prss46","annotation":"Serine protease 46; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000047912","abundance":0.571,"rank":13086,"name":"Slc16a9","annotation":"Monocarboxylate transporter 9; Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family."},{"id":"ENSMUSP00000112637","abundance":0.571,"rank":13087,"name":"Maml3","annotation":"Mastermind-like transcriptional coactivator 3."},{"id":"ENSMUSP00000097105","abundance":0.571,"rank":13088,"name":"Htr7","annotation":"5-hydroxytryptamine receptor 7; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000148441","abundance":0.571,"rank":13089,"name":"Cdkn2aip","annotation":"CDKN2A-interacting protein; Regulates DNA damage response and cell proliferation in a dose-dependent manner through a number of signaling pathways involved in cell proliferation, apoptosis and senescence. Belongs to the CARF family."},{"id":"ENSMUSP00000066620","abundance":0.571,"rank":13090,"name":"Per2","annotation":"Period circadian protein homolog 2; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardi [...] "},{"id":"ENSMUSP00000115342","abundance":0.571,"rank":13091,"name":"Uxt","annotation":"Protein UXT; Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain orga [...] "},{"id":"ENSMUSP00000090651","abundance":0.571,"rank":13092,"name":"Cntrob","annotation":"Centrobin; Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis (By similarity)."},{"id":"ENSMUSP00000041664","abundance":0.57,"rank":13093,"name":"Gpr26","annotation":"G-protein coupled receptor 26; Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP (By similarity); Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000022856","abundance":0.57,"rank":13094,"name":"Rad1","annotation":"Cell cycle checkpoint protein RAD1; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavag [...] "},{"id":"ENSMUSP00000044936","abundance":0.57,"rank":13095,"name":"Txlnb","annotation":"Beta-taxilin; Promotes motor nerve regeneration. May be involved in intracellular vesicle traffic (By similarity)."},{"id":"ENSMUSP00000137703","abundance":0.57,"rank":13096,"name":"1810049J17Rik","annotation":"RIKEN cDNA 1810049J17 gene."},{"id":"ENSMUSP00000102393","abundance":0.57,"rank":13097,"name":"Pars2","annotation":"Probable proline--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family."},{"id":"ENSMUSP00000027131","abundance":0.57,"rank":13098,"name":"Slc39a10","annotation":"Zinc transporter ZIP10; May act as a zinc-influx transporter; Belongs to the ZIP transporter (TC 2.A.5) family."},{"id":"ENSMUSP00000030152","abundance":0.569,"rank":13099,"name":"1110017D15Rik","annotation":"Spermatid-specific manchette-related protein 1; May be involved in differentiation or function of ciliated cells (By similarity). May play a role in spermatogenesis. Belongs to the SMRP1 family."},{"id":"ENSMUSP00000028248","abundance":0.569,"rank":13100,"name":"Ttll11","annotation":"Tubulin polyglutamylase TTLL11; Polyglutamase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Required for CCSAP localization to both spindle and cilia microtubules. Generates long side-chains. Belongs to the tubulin--tyrosine ligase family."},{"id":"ENSMUSP00000031235","abundance":0.569,"rank":13101,"name":"Gbp8","annotation":"Guanylate-binding protein 8."},{"id":"ENSMUSP00000028049","abundance":0.569,"rank":13102,"name":"Rabgap1l","annotation":"Rab GTPase-activating protein 1-like; GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables [...] "},{"id":"ENSMUSP00000050783","abundance":0.569,"rank":13103,"name":"Supt3","annotation":"SPT3, SAGA and STAGA complex component."},{"id":"ENSMUSP00000127109","abundance":0.569,"rank":13104,"name":"Runx1t1","annotation":"Protein CBFA2T1; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12 (By similarity). Acts as a negative regulator of adipogenesis."},{"id":"ENSMUSP00000097575","abundance":0.569,"rank":13105,"name":"Ttc30a2","annotation":"Tetratricopeptide repeat protein 30A2; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family."},{"id":"ENSMUSP00000034564","abundance":0.569,"rank":13106,"name":"2310030G06Rik","annotation":"Uncharacterized protein C11orf52 homolog."},{"id":"ENSMUSP00000150016","abundance":0.569,"rank":13107,"name":"Olfr1509","annotation":"Olfactory receptor 1509; Olfactory receptor that is activated by the binding of organosulfur odorants with thioether groups such as (methylthio)methanethiol (MTMT) and bis(methylthiomethyl) disulfide. Also binds odorants cis-cyclooctene and tert-butyl mercaptan. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (Potential)."},{"id":"ENSMUSP00000149943","abundance":0.569,"rank":13108,"name":"Olfr1176","annotation":"Olfactory receptor MOR174-5."},{"id":"ENSMUSP00000025236","abundance":0.568,"rank":13109,"name":"Stard4","annotation":"StAR-related lipid transfer protein 4; Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols."},{"id":"ENSMUSP00000006949","abundance":0.568,"rank":13110,"name":"Tph2","annotation":"Tryptophan 5-hydroxylase 2; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family."},{"id":"ENSMUSP00000076733","abundance":0.568,"rank":13111,"name":"Klk1b22","annotation":"Kallikrein 1-related peptidase b22; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000025081","abundance":0.568,"rank":13112,"name":"Zeb1","annotation":"Zinc finger E-box-binding homeobox 1; Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1 (By similarity). Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'- CANNTG-3'). P [...] "},{"id":"ENSMUSP00000099583","abundance":0.568,"rank":13113,"name":"Plcb2","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli (By similarity)."},{"id":"ENSMUSP00000098303","abundance":0.568,"rank":13114,"name":"P2rx7","annotation":"P2X purinoceptor 7; Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells."},{"id":"ENSMUSP00000045478","abundance":0.568,"rank":13115,"name":"Lzts2","annotation":"Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin."},{"id":"ENSMUSP00000075472","abundance":0.568,"rank":13116,"name":"Rnase11","annotation":"Putative inactive ribonuclease 11."},{"id":"ENSMUSP00000110323","abundance":0.567,"rank":13117,"name":"Gm1140","annotation":"Predicted gene 1140."},{"id":"ENSMUSP00000110320","abundance":0.567,"rank":13118,"name":"Gm14692","annotation":"Predicted gene 14692."},{"id":"ENSMUSP00000044582","abundance":0.566,"rank":13119,"name":"Polr3k","annotation":"DNA-directed RNA polymerase III subunit RPC10; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non- self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and  [...] "},{"id":"ENSMUSP00000086166","abundance":0.566,"rank":13120,"name":"Zfp948","annotation":"Zinc finger protein 948."},{"id":"ENSMUSP00000148767","abundance":0.566,"rank":13121,"name":"Nmur1","annotation":"Neuromedin-U receptor 1; Receptor for the neuromedin-U and neuromedin-S neuropeptides."},{"id":"ENSMUSP00000020706","abundance":0.566,"rank":13122,"name":"Adcy1","annotation":"Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels. May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina."},{"id":"ENSMUSP00000052042","abundance":0.566,"rank":13123,"name":"Akap17b","annotation":"A-kinase anchor protein 17B; Splice factor regulating alternative splice site selection for certain mRNA precursors."},{"id":"ENSMUSP00000083341","abundance":0.565,"rank":13124,"name":"Nfrkb","annotation":"Nuclear factor related to kappa-B-binding protein; Binds to the DNA consensus sequence 5'-GGGGAATCTCC-3'."},{"id":"ENSMUSP00000069768","abundance":0.565,"rank":13125,"name":"Tas2r117","annotation":"Taste receptor type 2 member 117; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000135375","abundance":0.565,"rank":13126,"name":"Bnc2","annotation":"Zinc finger protein basonuclin-2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes."},{"id":"ENSMUSP00000097576","abundance":0.565,"rank":13127,"name":"Ttc30b","annotation":"Tetratricopeptide repeat protein 30B; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family."},{"id":"ENSMUSP00000047573","abundance":0.565,"rank":13128,"name":"Lrfn2","annotation":"Leucine-rich repeat and fibronectin type-III domain-containing protein 2; Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of 2 NMDA receptor subunits GRIN1 and GRIN2A (By similarity). May play a role in redistributing DLG4 to the cell periphery; Belongs to the LRFN family."},{"id":"ENSMUSP00000003469","abundance":0.564,"rank":13129,"name":"Cd79a","annotation":"B-cell antigen receptor complex-associated protein alpha chain; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B- cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts wit [...] "},{"id":"ENSMUSP00000086363","abundance":0.564,"rank":13130,"name":"Lrch1","annotation":"Leucine-rich repeat and calponin homology domain-containing protein 1; Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration in response to chemokine stimulation."},{"id":"ENSMUSP00000002081","abundance":0.564,"rank":13131,"name":"Srpk3","annotation":"SRSF protein kinase 3; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development."},{"id":"ENSMUSP00000031096","abundance":0.564,"rank":13132,"name":"Klb","annotation":"Beta-klotho; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21."},{"id":"ENSMUSP00000021045","abundance":0.564,"rank":13133,"name":"Asic2","annotation":"Acid-sensing ion channel 2; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate."},{"id":"ENSMUSP00000001611","abundance":0.563,"rank":13134,"name":"Nom1","annotation":"Nucleolar MIF4G domain-containing protein 1; Plays a role in targeting PPP1CA to the nucleolus."},{"id":"ENSMUSP00000029651","abundance":0.563,"rank":13135,"name":"Gstcd","annotation":"Glutathione S-transferase C-terminal domain-containing protein; Belongs to the GSTCD family."},{"id":"ENSMUSP00000046891","abundance":0.563,"rank":13136,"name":"Myrip","annotation":"Rab effector MyRIP; Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments. Functions as a protein kinase A-anchoring protein (AKAP). May act as a scaffolding protein that links PKA to components of the exocytosis machinery, thus facilitating exocytosis, including insulin release."},{"id":"ENSMUSP00000127347","abundance":0.562,"rank":13137,"name":"Skint7","annotation":"Selection and upkeep of intraepithelial T-cells protein 7; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus."},{"id":"ENSMUSP00000038106","abundance":0.562,"rank":13138,"name":"Slc12a9","annotation":"Solute carrier family 12 member 9; May be an inhibitor of SLC12A1. Seems to correspond to a subunit of a multimeric transport system and thus, additional subunits may be required for its function (By similarity)."},{"id":"ENSMUSP00000150706","abundance":0.562,"rank":13139,"name":"Olfr1082","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000067882","abundance":0.562,"rank":13140,"name":"Tbcel","annotation":"Tubulin-specific chaperone cofactor E-like protein; Acts as a regulator of tubulin stability."},{"id":"ENSMUSP00000097484","abundance":0.561,"rank":13141,"name":"Olfr1048","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000082694","abundance":0.561,"rank":13142,"name":"Mtus2","annotation":"Microtubule-associated tumor suppressor candidate 2 homolog; Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip (By similarity)."},{"id":"ENSMUSP00000130497","abundance":0.561,"rank":13143,"name":"Mc5r","annotation":"Melanocortin receptor 5; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins."},{"id":"ENSMUSP00000133933","abundance":0.561,"rank":13144,"name":"Setd1b","annotation":"Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression; Belongs to the class V-like SAM-binding methyltransferase superfamily."},{"id":"ENSMUSP00000146943","abundance":0.561,"rank":13145,"name":"Gm4756","annotation":"Predicted gene 4756; Belongs to the short-chain dehydrogenases/reductases (SDR) family."},{"id":"ENSMUSP00000026828","abundance":0.561,"rank":13146,"name":"Mcrip2","annotation":"MAPK regulated corepressor interacting protein 2; Belongs to the MCRIP family."},{"id":"ENSMUSP00000002457","abundance":0.56,"rank":13147,"name":"Bmp8b","annotation":"Bone morphogenetic protein 8B; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Involved in the generation of primordial germ cells; this function involves Bmp4 in a synergistic manner though separate receptor complexes seem to be involved. Required for the initiation and maintenance of spermatogenesis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown a [...] "},{"id":"ENSMUSP00000029504","abundance":0.56,"rank":13148,"name":"Cym","annotation":"Gene model 131, (NCBI); Belongs to the peptidase A1 family."},{"id":"ENSMUSP00000002360","abundance":0.56,"rank":13149,"name":"Angptl4","annotation":"Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stress fibers and fo [...] "},{"id":"ENSMUSP00000037192","abundance":0.56,"rank":13150,"name":"Kcnj2","annotation":"Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] "},{"id":"ENSMUSP00000148582","abundance":0.56,"rank":13151,"name":"Dnmbp","annotation":"Dynamin-binding protein; Plays a critical role as a guanine nucleotide exchange factor (GEF) for CDC42 in several intracellular processes associated with the actin and microtubule cytoskeleton. Regulates the structure of apical junctions in epithelial cells (By similarity). Participates in the normal lumenogenesis of epithelial cell cysts by regulating spindle orientation (By similarity). Plays a role in ciliogenesis (By similarity). May play a role in membrane trafficking between the cell surface and the Golgi."},{"id":"ENSMUSP00000064839","abundance":0.56,"rank":13152,"name":"Ttk","annotation":"Dual specificity protein kinase TTK; Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint (By similarity). Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. May play some role in the control of cell proliferation or differentiation and could be involved in modulating different levels of signal transduction pathways."},{"id":"ENSMUSP00000091226","abundance":0.559,"rank":13153,"name":"Sp110","annotation":"Sp110 nuclear body protein; May act as a transcription factor. Plays a role in the innate immunity against intracellular pathogens. Required for resistance to M.tuberculosis and L.monocytogenes. Promotes apoptosis of infected cells."},{"id":"ENSMUSP00000024851","abundance":0.559,"rank":13154,"name":"Ndc80","annotation":"Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spind [...] "},{"id":"ENSMUSP00000027401","abundance":0.559,"rank":13155,"name":"Stk16","annotation":"Serine/threonine-protein kinase 16; Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates (By similarity). May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins."},{"id":"ENSMUSP00000063648","abundance":0.559,"rank":13156,"name":"Impg2","annotation":"Interphotoreceptor matrix proteoglycan 2; Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin."},{"id":"ENSMUSP00000121576","abundance":0.559,"rank":13157,"name":"Cnbd1","annotation":"Cyclic nucleotide-binding domain-containing 1."},{"id":"ENSMUSP00000104845","abundance":0.559,"rank":13158,"name":"Chst4","annotation":"Carbohydrate sulfotransferase 4; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of SELL ligand sialyl 6-sulfo Lewis X on SELL counter- receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL liga [...] "},{"id":"ENSMUSP00000025276","abundance":0.558,"rank":13159,"name":"Rmc1","annotation":"Regulator of MON1-CCZ1 complex; Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization. Belongs to the RMC1 family."},{"id":"ENSMUSP00000025944","abundance":0.558,"rank":13160,"name":"Hhex","annotation":"Hematopoietically-expressed homeobox protein Hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL."},{"id":"ENSMUSP00000022537","abundance":0.558,"rank":13161,"name":"Prss52","annotation":"Serine protease 52; Probable serine protease; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000089388","abundance":0.558,"rank":13162,"name":"Tshz1","annotation":"Teashirt homolog 1; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential)."},{"id":"ENSMUSP00000136491","abundance":0.557,"rank":13163,"name":"Btbd35f6","annotation":"BTB domain-containing 35, family member 6."},{"id":"ENSMUSP00000013771","abundance":0.557,"rank":13164,"name":"Trim54","annotation":"Tripartite motif-containing protein 54; May bind and stabilize microtubules during myotubes formation."},{"id":"ENSMUSP00000145741","abundance":0.557,"rank":13165,"name":"Olfr403","annotation":"Olfactory receptor Olfr403."},{"id":"ENSMUSP00000104558","abundance":0.557,"rank":13166,"name":"Gm14326","annotation":"Zinc finger protein."},{"id":"ENSMUSP00000123701","abundance":0.557,"rank":13167,"name":"Klhl3","annotation":"Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity). The BCR(KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney."},{"id":"ENSMUSP00000022828","abundance":0.557,"rank":13168,"name":"Emc9","annotation":"ER membrane protein complex subunit 9; Belongs to the EMC8/EMC9 family."},{"id":"ENSMUSP00000150506","abundance":0.556,"rank":13169,"name":"Olfr901","annotation":"Olfactory receptor Olfr901."},{"id":"ENSMUSP00000030179","abundance":0.556,"rank":13170,"name":"Cd72","annotation":"B-cell differentiation antigen CD72; Plays a role in B-cell proliferation and differentiation."},{"id":"ENSMUSP00000158734","abundance":0.556,"rank":13171,"name":"Btbd35f8","annotation":"BTB domain-containing 35, family member 8."},{"id":"ENSMUSP00000067701","abundance":0.556,"rank":13172,"name":"Thsd1","annotation":"Thrombospondin type-1 domain-containing protein 1."},{"id":"ENSMUSP00000057993","abundance":0.555,"rank":13173,"name":"Saxo2","annotation":"Stabilizer of axonemal microtubules 2; Belongs to the FAM154 family."},{"id":"ENSMUSP00000028835","abundance":0.555,"rank":13174,"name":"Crls1","annotation":"Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions."},{"id":"ENSMUSP00000068007","abundance":0.555,"rank":13175,"name":"Hunk","annotation":"Hormonally up-regulated neu tumor-associated kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily."},{"id":"ENSMUSP00000154099","abundance":0.555,"rank":13176,"name":"Kbtbd6","annotation":"Kelch repeat and BTB (POZ) domain-containing 6."},{"id":"ENSMUSP00000027859","abundance":0.555,"rank":13177,"name":"Tbx19","annotation":"T-box transcription factor TBX19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters."},{"id":"ENSMUSP00000037629","abundance":0.555,"rank":13178,"name":"Slc16a2","annotation":"Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family."},{"id":"ENSMUSP00000150524","abundance":0.555,"rank":13179,"name":"Olfr612","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000075497","abundance":0.555,"rank":13180,"name":"Fnip2","annotation":"Folliculin-interacting protein 2; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1 (By similarity). May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions ; Belongs to the FNIP family."},{"id":"ENSMUSP00000069165","abundance":0.555,"rank":13181,"name":"9330182L06Rik","annotation":"UPF0577 protein KIAA1324-like homolog; Belongs to the UPF0577 family."},{"id":"ENSMUSP00000082270","abundance":0.555,"rank":13182,"name":"Msl2","annotation":"E3 ubiquitin-protein ligase MSL2; Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure (By similarity). Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and  [...] "},{"id":"ENSMUSP00000045675","abundance":0.555,"rank":13183,"name":"Pkd2l1","annotation":"Polycystic kidney disease 2-like 1 protein; Pore-forming subunit of a heteromeric, non-selective cation channel that is permeable to Ca(2+). Pore-forming subunit of a calcium-permeant ion channel formed by PKD1L2 and PKD1L1 in primary cilia, where it controls cilium calcium concentration, but does not affect cytoplasmic calcium concentration. The channel formed by PKD1L2 and PKD1L1 in primary cilia regulates sonic hedgehog/SHH signaling and GLI2 transcription. Pore-forming subunit of a channel formed by PKD1L2 and PKD1L3 that contributes to sour taste perception in gustatory cells. The [...] "},{"id":"ENSMUSP00000148012","abundance":0.554,"rank":13184,"name":"Bicra","annotation":"BRD4-interacting chromatin-remodeling complex-associated protein; Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner. May play a role in BRD4-mediated gene transcription (By similarity)."},{"id":"ENSMUSP00000065544","abundance":0.554,"rank":13185,"name":"Azin1","annotation":"Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production."},{"id":"ENSMUSP00000047467","abundance":0.554,"rank":13186,"name":"Usp28","annotation":"Ubiquitin carboxyl-terminal hydrolase 28; Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). In contrast, it does not deubiquitinate PLK1. Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome: acts by specifically intera [...] "},{"id":"ENSMUSP00000073220","abundance":0.554,"rank":13187,"name":"Thsd7b","annotation":"Thrombospondin type-1 domain-containing protein 7B."},{"id":"ENSMUSP00000064929","abundance":0.554,"rank":13188,"name":"Socs6","annotation":"Suppressor of cytokine signaling 6; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5- SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine- phosphorylated receptor (By similarity)."},{"id":"ENSMUSP00000021050","abundance":0.554,"rank":13189,"name":"Adap2","annotation":"Arf-GAP with dual PH domain-containing protein 2; GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity (By similarity)."},{"id":"ENSMUSP00000064893","abundance":0.554,"rank":13190,"name":"Arfgap3","annotation":"ADP-ribosylation factor GTPase-activating protein 3; GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)."},{"id":"ENSMUSP00000104155","abundance":0.553,"rank":13191,"name":"Nlrp1b","annotation":"NACHT, LRR and PYD domains-containing protein 1b allele 2; As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of Nlrp1b, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMG [...] "},{"id":"ENSMUSP00000028648","abundance":0.553,"rank":13192,"name":"Syt13","annotation":"Synaptotagmin-13; May be involved in transport vesicle docking to the plasma membrane."},{"id":"ENSMUSP00000155014","abundance":0.553,"rank":13193,"name":"Wnt7b","annotation":"Protein Wnt-7b; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation."},{"id":"ENSMUSP00000150961","abundance":0.553,"rank":13194,"name":"Olfr1396","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000129784","abundance":0.553,"rank":13195,"name":"Akap13","annotation":"A-kinase anchor protein 13; Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein- coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of  [...] "},{"id":"ENSMUSP00000022699","abundance":0.552,"rank":13196,"name":"Gfra2","annotation":"GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor."},{"id":"ENSMUSP00000076224","abundance":0.552,"rank":13197,"name":"Zdhhc8","annotation":"Probable palmitoyltransferase ZDHHC8; Palmitoyltransferase involved in glutamatergic transmission. Mediates palmitoylation of ABCA1; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily."},{"id":"ENSMUSP00000132378","abundance":0.552,"rank":13198,"name":"Pde7b","annotation":"cAMP-specific 3',5'-cyclic phosphodiesterase 7B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain."},{"id":"ENSMUSP00000044432","abundance":0.552,"rank":13199,"name":"Zgrf1","annotation":"Protein ZGRF1."},{"id":"ENSMUSP00000022536","abundance":0.552,"rank":13200,"name":"Ska3","annotation":"Spindle and kinetochore-associated protein 3; Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the p [...] "},{"id":"ENSMUSP00000119308","abundance":0.552,"rank":13201,"name":"Rxylt1","annotation":"Ribitol-5-phosphate xylosyltransferase 1; UDP-xylosyltransferase involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3- N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Acts as a UDP-D-xylose:ribitol-5- phosphate beta1,4-xylosyltransferase, which catalyzes the transfer of UDP-D-xylose to ribitol 5-phosphate (Rbo5P) to form the Xylbeta1-4Rbo5P linkage  [...] "},{"id":"ENSMUSP00000048345","abundance":0.551,"rank":13202,"name":"Hectd4","annotation":"HECT domain E3 ubiquitin protein ligase 4."},{"id":"ENSMUSP00000026897","abundance":0.551,"rank":13203,"name":"Slco3a1","annotation":"Solute carrier organic anion transporter family member 3A1; Mediates the Na(+)-independent transport of organic anions. Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin."},{"id":"ENSMUSP00000054910","abundance":0.551,"rank":13204,"name":"Kcng3","annotation":"Potassium voltage-gated channel subfamily G member 3; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1."},{"id":"ENSMUSP00000152502","abundance":0.551,"rank":13205,"name":"Zfp72","annotation":"Zinc finger protein 72."},{"id":"ENSMUSP00000050996","abundance":0.55,"rank":13206,"name":"Ccdc57","annotation":"Coiled-coil domain-containing protein 57."},{"id":"ENSMUSP00000026296","abundance":0.55,"rank":13207,"name":"Fgd1","annotation":"FYVE, RhoGEF and PH domain-containing protein 1; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape."},{"id":"ENSMUSP00000088725","abundance":0.55,"rank":13208,"name":"Intu","annotation":"Protein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex [...] "},{"id":"ENSMUSP00000100043","abundance":0.55,"rank":13209,"name":"Zfp184","annotation":"Zinc finger protein 184; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000063665","abundance":0.55,"rank":13210,"name":"Lypd9","annotation":"LY6/PLAUR domain-containing 9."},{"id":"ENSMUSP00000060137","abundance":0.549,"rank":13211,"name":"Fbxl22","annotation":"F-box and leucine-rich protein 22; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes ubiquitination of sarcomeric proteins alpha-actinin-2 (ACTN2) and filamin-C (FLNC) (By similarity)."},{"id":"ENSMUSP00000052149","abundance":0.549,"rank":13212,"name":"Utp14b","annotation":"U3 small nucleolar RNA-associated protein 14 homolog B; Essential for spermatogenesis. May be required specifically for ribosome biogenesis and hence protein synthesis during male meiosis; Belongs to the UTP14 family."},{"id":"ENSMUSP00000099444","abundance":0.549,"rank":13213,"name":"Ttll9","annotation":"Probable tubulin polyglutamylase TTLL9; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Acts when complexed with other proteins (Probable). By mediating tubulin polyglutamylation, plays a role in the establishment of microtubule heterogeneity in sperm flagella."},{"id":"ENSMUSP00000113521","abundance":0.549,"rank":13214,"name":"Rab11fip3","annotation":"Rab11 family-interacting protein 3; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). Also required for the structural integrity of the endosomal recycling compartment during interphase. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facili [...] "},{"id":"ENSMUSP00000048119","abundance":0.549,"rank":13215,"name":"Ptpn13","annotation":"Tyrosine-protein phosphatase non-receptor type 13; Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily."},{"id":"ENSMUSP00000124381","abundance":0.549,"rank":13216,"name":"Nxpe5","annotation":"Neurexophilin and PC-esterase domain family, member 5."},{"id":"ENSMUSP00000111659","abundance":0.548,"rank":13217,"name":"Fads3","annotation":"Fatty acid desaturase 3; Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate) at carbon 13 to generate (11E,13Z)-octadecadienoate, likely participating in the biohydrogenation pathway of linoleic acid (LA) (18:2n-6)."},{"id":"ENSMUSP00000050881","abundance":0.548,"rank":13218,"name":"Fam228b","annotation":"Protein FAM228B."},{"id":"ENSMUSP00000148422","abundance":0.548,"rank":13219,"name":"Carmil2","annotation":"Capping protein, Arp2/3 and myosin-I linker protein 2; Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during woun [...] "},{"id":"ENSMUSP00000022567","abundance":0.548,"rank":13220,"name":"Cacna2d3","annotation":"Voltage-dependent calcium channel subunit alpha-2/delta-3; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G)."},{"id":"ENSMUSP00000124816","abundance":0.548,"rank":13221,"name":"Hr","annotation":"Lysine-specific demethylase hairless; Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle (By similarity)."},{"id":"ENSMUSP00000072039","abundance":0.548,"rank":13222,"name":"Nuak2","annotation":"NUAK family SNF1-like kinase 2; Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1 (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily."},{"id":"ENSMUSP00000030586","abundance":0.548,"rank":13223,"name":"Ccdc28b","annotation":"Coiled-coil domain-containing protein 28B; Involved in ciliogenesis. Regulates cilia length through its interaction with MAPKAP1/SIN1 but independently of mTORC2 complex. Modulates mTORC2 complex assembly and function, possibly enhances AKT1 phosphorylation. Does not seem to modulate assembly and function of mTORC1 complex."},{"id":"ENSMUSP00000081941","abundance":0.548,"rank":13224,"name":"Crtap","annotation":"Cartilage-associated protein; Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues; Belongs to the leprecan family."},{"id":"ENSMUSP00000142477","abundance":0.548,"rank":13225,"name":"Chil5","annotation":"Chitinase-like 5; Belongs to the glycosyl hydrolase 18 family."},{"id":"ENSMUSP00000022612","abundance":0.548,"rank":13226,"name":"Pbk","annotation":"Lymphokine-activated killer T-cell-originated protein kinase; Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization (By similarity)."},{"id":"ENSMUSP00000091357","abundance":0.548,"rank":13227,"name":"Trcg1","annotation":"Taste receptor cell protein 1."},{"id":"ENSMUSP00000104554","abundance":0.548,"rank":13228,"name":"Zfp971","annotation":"Zinc finger protein 971."},{"id":"ENSMUSP00000113091","abundance":0.548,"rank":13229,"name":"Lilra5","annotation":"Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5."},{"id":"ENSMUSP00000151088","abundance":0.547,"rank":13230,"name":"Olfr1100","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000031536","abundance":0.547,"rank":13231,"name":"Mrm2","annotation":"rRNA methyltransferase 2, mitochondrial; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA."},{"id":"ENSMUSP00000022623","abundance":0.547,"rank":13232,"name":"Trim35","annotation":"Tripartite motif-containing protein 35; Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (By similarity). Implicated in the cell death mechanism."},{"id":"ENSMUSP00000009219","abundance":0.546,"rank":13233,"name":"Cabp7","annotation":"Calcium-binding protein 7; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity."},{"id":"ENSMUSP00000151388","abundance":0.546,"rank":13234,"name":"Cep290","annotation":"Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. Its association with CCP110 is required for inhibition of primary cilia formation by CCP110 (By similarity). May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1 (By similarity). Required for the correct localization of ciliary and phototransduction  [...] "},{"id":"ENSMUSP00000040347","abundance":0.546,"rank":13235,"name":"Tmco3","annotation":"Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter."},{"id":"ENSMUSP00000066894","abundance":0.546,"rank":13236,"name":"Ngef","annotation":"Ephexin-1; Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension."},{"id":"ENSMUSP00000087879","abundance":0.546,"rank":13237,"name":"Dlg5","annotation":"Disks large homolog 5; Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT [...] "},{"id":"ENSMUSP00000073866","abundance":0.546,"rank":13238,"name":"Sh2d3c","annotation":"SH2 domain-containing protein 3C; Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration."},{"id":"ENSMUSP00000031653","abundance":0.546,"rank":13239,"name":"Flt1","annotation":"Vascular endothelial growth factor receptor 1; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferati [...] "},{"id":"ENSMUSP00000089265","abundance":0.546,"rank":13240,"name":"Pramel4","annotation":"Preferentially-expressed antigen in melanoma-like 4."},{"id":"ENSMUSP00000101387","abundance":0.546,"rank":13241,"name":"Gm13102","annotation":"Predicted gene 13102."},{"id":"ENSMUSP00000002880","abundance":0.546,"rank":13242,"name":"Btbd6","annotation":"BTB/POZ domain-containing protein 6; Adapter protein for the cul3 E3 ubiquitin-protein ligase complex (By similarity). Involved in late neuronal development and muscle formation (By similarity)."},{"id":"ENSMUSP00000147250","abundance":0.545,"rank":13243,"name":"Ryr3","annotation":"Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers  [...] "},{"id":"ENSMUSP00000018767","abundance":0.545,"rank":13244,"name":"Mmp7","annotation":"Matrilysin; Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase (By similarity)."},{"id":"ENSMUSP00000008445","abundance":0.545,"rank":13245,"name":"Phax","annotation":"Phosphorylated adapter RNA export protein; A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric imp [...] "},{"id":"ENSMUSP00000037850","abundance":0.545,"rank":13246,"name":"Evpl","annotation":"Envoplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments."},{"id":"ENSMUSP00000075174","abundance":0.545,"rank":13247,"name":"Megf10","annotation":"Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment (By similarity). Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte- dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesi [...] "},{"id":"ENSMUSP00000080911","abundance":0.545,"rank":13248,"name":"Slc39a12","annotation":"Zinc transporter ZIP12; Acts as a zinc-influx transporter."},{"id":"ENSMUSP00000105970","abundance":0.545,"rank":13249,"name":"Bcl2l11","annotation":"Bcl-2-like protein 11; Induces apoptosis and anoikis. The isoforms vary in cytotoxicity with isoform BimS being the most potent and isoform BimEL being the least potent; Belongs to the Bcl-2 family."},{"id":"ENSMUSP00000062078","abundance":0.545,"rank":13250,"name":"Dntt","annotation":"DNA nucleotidylexotransferase; [Isoform TDT-S]: Transferase that catalyzes the nontemplated addition of nucleoside triphosphate to coding ends during V(D)J recombination (N addition). Involved in the generation of diversity in the antigen-binding region of immunoglobulin heavy and light chains and T-cell receptors during B- and T-cell development. Does not act on double-stranded DNA with blunt ends. Belongs to the DNA polymerase type-X family."},{"id":"ENSMUSP00000101374","abundance":0.545,"rank":13251,"name":"Aadacl4fm2","annotation":"AADACL4 family member 2."},{"id":"ENSMUSP00000126119","abundance":0.545,"rank":13252,"name":"Cyb5r4","annotation":"Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS)."},{"id":"ENSMUSP00000098235","abundance":0.545,"rank":13253,"name":"Csmd3","annotation":"CUB and sushi domain-containing protein 3; Involved in dendrite development."},{"id":"ENSMUSP00000026617","abundance":0.545,"rank":13254,"name":"Phkg1","annotation":"Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform; Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3 (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family."},{"id":"ENSMUSP00000079647","abundance":0.544,"rank":13255,"name":"Zfp82","annotation":"Zinc finger protein 82; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000126861","abundance":0.544,"rank":13256,"name":"Sgk3","annotation":"Serine/threonine-protein kinase Sgk3; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate [...] "},{"id":"ENSMUSP00000020908","abundance":0.544,"rank":13257,"name":"E2f6","annotation":"Transcription factor E2F6; Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'- TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overex [...] "},{"id":"ENSMUSP00000032194","abundance":0.544,"rank":13258,"name":"Bhlhe40","annotation":"Class E basic helix-loop-helix protein 40; Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2 (By similarity). Represses the activity of the circadian transcriptional activator: CLOCK- ARN [...] "},{"id":"ENSMUSP00000027302","abundance":0.544,"rank":13259,"name":"Ptpn18","annotation":"Tyrosine-protein phosphatase non-receptor type 18; May be involved in growth and differentiation of hematopoietic cells."},{"id":"ENSMUSP00000035435","abundance":0.544,"rank":13260,"name":"Cpa6","annotation":"Carboxypeptidase A6; May be involved in the proteolytic inactivation of enkephalins and neurotensin in some brain areas. May convert inactive angiotensin I into the biologically active angiotensin II. Releases a C-terminal amino acid, with preference for large hydrophobic C-terminal amino acids and shows only very weak activity toward small amino acids and histidine."},{"id":"ENSMUSP00000130349","abundance":0.544,"rank":13261,"name":"Arhgap40","annotation":"Rho GTPase-activating protein 40; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state."},{"id":"ENSMUSP00000095966","abundance":0.544,"rank":13262,"name":"Necab2","annotation":"N-terminal EF-hand calcium-binding protein 2; May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation."},{"id":"ENSMUSP00000032663","abundance":0.543,"rank":13263,"name":"Ceacam18","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 18; Belongs to the immunoglobulin superfamily. CEA family."},{"id":"ENSMUSP00000055253","abundance":0.543,"rank":13264,"name":"Proser1","annotation":"Proline and serine-rich protein 1."},{"id":"ENSMUSP00000099774","abundance":0.543,"rank":13265,"name":"4933409G03Rik","annotation":"RIKEN cDNA 4933409G03 gene."},{"id":"ENSMUSP00000044222","abundance":0.543,"rank":13266,"name":"Pramel5","annotation":"Preferentially-expressed antigen in melanoma-like 5."},{"id":"ENSMUSP00000088535","abundance":0.543,"rank":13267,"name":"Map9","annotation":"Microtubule-associated protein 9; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules (By similarity)."},{"id":"ENSMUSP00000136452","abundance":0.543,"rank":13268,"name":"LOC102633783","annotation":"Sp110 nuclear body protein-like."},{"id":"ENSMUSP00000135921","abundance":0.543,"rank":13269,"name":"ENSMUSP00000135921","annotation":"Sp110 nuclear body protein-like."},{"id":"ENSMUSP00000137208","abundance":0.543,"rank":13270,"name":"ENSMUSP00000137208","annotation":"annotation not available"},{"id":"ENSMUSP00000094130","abundance":0.543,"rank":13271,"name":"Gml2","annotation":"Glycosylphosphatidylinositol-anchored molecule-like 2."},{"id":"ENSMUSP00000032627","abundance":0.542,"rank":13272,"name":"Tubgcp5","annotation":"Gamma-tubulin complex component 5; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family."},{"id":"ENSMUSP00000140465","abundance":0.542,"rank":13273,"name":"Prob1","annotation":"Proline-rich basic protein 1."},{"id":"ENSMUSP00000130767","abundance":0.542,"rank":13274,"name":"Rhbg","annotation":"Ammonium transporter Rh type B; Functions as a specific ammonium transporter. Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily."},{"id":"ENSMUSP00000038835","abundance":0.542,"rank":13275,"name":"Kazn","annotation":"Kazrin; Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known."},{"id":"ENSMUSP00000059798","abundance":0.542,"rank":13276,"name":"Ube2q2","annotation":"Ubiquitin-conjugating enzyme E2 Q2; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'- linked polyubiquitination; Belongs to the ubiquitin-conjugating enzyme family."},{"id":"ENSMUSP00000099465","abundance":0.542,"rank":13277,"name":"Mib2","annotation":"E3 ubiquitin-protein ligase MIB2; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors."},{"id":"ENSMUSP00000139350","abundance":0.541,"rank":13278,"name":"Kcnn2","annotation":"Small conductance calcium-activated potassium channel protein 2; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin; Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily."},{"id":"ENSMUSP00000029822","abundance":0.541,"rank":13279,"name":"Tacr3","annotation":"Neuromedin-K receptor; This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system."},{"id":"ENSMUSP00000120149","abundance":0.541,"rank":13280,"name":"Zscan4f","annotation":"Zinc finger and SCAN domain containing protein 4F; Transcription factor required to regulate early development. Binds telomeres and plays a key role in genomic stability by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation (By similarity)."},{"id":"ENSMUSP00000089014","abundance":0.541,"rank":13281,"name":"Zscan4-ps2","annotation":"Zinc finger and SCAN domain containing 4, pseudogene 2."},{"id":"ENSMUSP00000147776","abundance":0.541,"rank":13282,"name":"Usp17le","annotation":"Ubiquitin carboxyl-terminal hydrolase 17-like protein E; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection; Belongs to the peptidase C19 family. USP17 subfamily."},{"id":"ENSMUSP00000145400","abundance":0.541,"rank":13283,"name":"Olfr803","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000053420","abundance":0.541,"rank":13284,"name":"Cldn4","annotation":"Claudin-4; Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity."},{"id":"ENSMUSP00000018521","abundance":0.541,"rank":13285,"name":"Vezf1","annotation":"Vascular endothelial zinc finger 1."},{"id":"ENSMUSP00000022292","abundance":0.541,"rank":13286,"name":"Samd8","annotation":"Sphingomyelin synthase-related protein 1; sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphatidylethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the ea [...] "},{"id":"ENSMUSP00000128415","abundance":0.541,"rank":13287,"name":"Iltifb","annotation":"Interleukin-22b; Cytokine that contributes to the inflammatory response in vivo; Belongs to the IL-10 family."},{"id":"ENSMUSP00000043953","abundance":0.54,"rank":13288,"name":"Tango6","annotation":"Transport and Golgi organization protein 6 homolog; Belongs to the Tango6 family."},{"id":"ENSMUSP00000133309","abundance":0.54,"rank":13289,"name":"Znrf1","annotation":"E3 ubiquitin-protein ligase ZNRF1; E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes Wallerian degeneration, a neurodegeneration disorder, by mediating 'Lys-48'- linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation  [...] "},{"id":"ENSMUSP00000077741","abundance":0.54,"rank":13290,"name":"Samd12","annotation":"Sterile alpha motif domain-containing protein 12."},{"id":"ENSMUSP00000083583","abundance":0.54,"rank":13291,"name":"Gpr25","annotation":"Probable G-protein coupled receptor 25; Orphan receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000148408","abundance":0.54,"rank":13292,"name":"Crhr2","annotation":"Corticotropin-releasing factor receptor 2; G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels."},{"id":"ENSMUSP00000042413","abundance":0.54,"rank":13293,"name":"Dlx1","annotation":"Homeobox protein DLX-1; Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation (By similarity). Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning a [...] "},{"id":"ENSMUSP00000139630","abundance":0.54,"rank":13294,"name":"Tet3","annotation":"Methylcytosine dioxygenase TET3; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5- carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression  [...] "},{"id":"ENSMUSP00000123752","abundance":0.54,"rank":13295,"name":"Apbb2","annotation":"Amyloid-beta A4 precursor protein-binding family B member 2; May modulate the internalization of amyloid-beta precursor protein."},{"id":"ENSMUSP00000149019","abundance":0.54,"rank":13296,"name":"Olfr31","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000104820","abundance":0.539,"rank":13297,"name":"Zfp62","annotation":"Zinc finger protein 62; May play a role in differentiating skeletal muscle."},{"id":"ENSMUSP00000031078","abundance":0.539,"rank":13298,"name":"1700001C02Rik","annotation":"Protein FAM166C."},{"id":"ENSMUSP00000148239","abundance":0.539,"rank":13299,"name":"Zscan18","annotation":"Zinc finger and SCAN domain-containing 18."},{"id":"ENSMUSP00000077513","abundance":0.539,"rank":13300,"name":"Trim61","annotation":"Tripartite motif-containing 61."},{"id":"ENSMUSP00000021641","abundance":0.539,"rank":13301,"name":"Tshz3","annotation":"Teashirt homolog 3; Transcriptional regulator involved in developmental processes. Functions in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway func [...] "},{"id":"ENSMUSP00000125604","abundance":0.539,"rank":13302,"name":"Gstt4","annotation":"Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family."},{"id":"ENSMUSP00000045156","abundance":0.539,"rank":13303,"name":"Zfhx2","annotation":"Zinc finger homeobox protein 2; Transcriptional regulator that is critical for the regulation of pain perception and processing of noxious stimuli."},{"id":"ENSMUSP00000034630","abundance":0.539,"rank":13304,"name":"Fez1","annotation":"Fasciculation and elongation protein zeta-1; May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. May participate in the transport of mitochondria and other cargos along microtubules (By similarity)."},{"id":"ENSMUSP00000100624","abundance":0.539,"rank":13305,"name":"Btbd35f7","annotation":"BTB domain-containing 35, family member 7."},{"id":"ENSMUSP00000052425","abundance":0.539,"rank":13306,"name":"Olfr215","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000053080","abundance":0.539,"rank":13307,"name":"Spata21","annotation":"Spermatogenesis-associated protein 21; Involved in the differentiation of haploid spermatids."},{"id":"ENSMUSP00000023243","abundance":0.538,"rank":13308,"name":"Gpihbp1","annotation":"Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries. Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. Binds chylomicrons and phospholipid particles that contain APOA5. Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL."},{"id":"ENSMUSP00000092038","abundance":0.538,"rank":13309,"name":"Entpd6","annotation":"Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family."},{"id":"ENSMUSP00000113540","abundance":0.538,"rank":13310,"name":"Crtc3","annotation":"CREB-regulated transcription coactivator 3; Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated. Acts independently of CREB1 'Ser-133' phosphorylation (By similarity). Enhances the interaction of CREB1 with TAF4 (By similarity). Regulates the expression of specific CREB- activated genes such as the steroidogenic gene, StAR (By similarity). Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis  [...] "},{"id":"ENSMUSP00000051041","abundance":0.538,"rank":13311,"name":"Pcdhb7","annotation":"Protocadherin beta 7."},{"id":"ENSMUSP00000044866","abundance":0.537,"rank":13312,"name":"Sos2","annotation":"Son of sevenless homolog 2; Promotes the exchange of Ras-bound GDP by GTP."},{"id":"ENSMUSP00000028536","abundance":0.537,"rank":13313,"name":"Arl14ep","annotation":"ARL14 effector protein; Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells."},{"id":"ENSMUSP00000109144","abundance":0.537,"rank":13314,"name":"Kdr","annotation":"Vascular endothelial growth factor receptor 2; Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as a negative regulator of VE [...] "},{"id":"ENSMUSP00000064718","abundance":0.537,"rank":13315,"name":"Dsg3","annotation":"Desmoglein-3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion."},{"id":"ENSMUSP00000069359","abundance":0.537,"rank":13316,"name":"Nat3","annotation":"Arylamine N-acetyltransferase 3; Participates in the detoxification of a plethora of hydrazine and arylamine drugs."},{"id":"ENSMUSP00000006286","abundance":0.537,"rank":13317,"name":"Inpp5k","annotation":"Inositol polyphosphate 5-phosphatase K; Inositol 5-phosphatase which acts on inositol 1,4,5- trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6- fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (By similarity). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle."},{"id":"ENSMUSP00000010249","abundance":0.537,"rank":13318,"name":"Tmem179b","annotation":"Transmembrane protein 179B."},{"id":"ENSMUSP00000127187","abundance":0.536,"rank":13319,"name":"Dennd2c","annotation":"DENN domain-containing protein 2C; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form."},{"id":"ENSMUSP00000002891","abundance":0.536,"rank":13320,"name":"Top3a","annotation":"DNA topoisomerase 3-alpha; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils [...] "},{"id":"ENSMUSP00000031655","abundance":0.536,"rank":13321,"name":"Slc46a3","annotation":"Solute carrier family 46 member 3."},{"id":"ENSMUSP00000031354","abundance":0.536,"rank":13322,"name":"Abcb9","annotation":"ATP-binding cassette sub-family B member 9; ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C- terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (By similarity). Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) sub [...] "},{"id":"ENSMUSP00000057433","abundance":0.536,"rank":13323,"name":"Ceacam19","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 19."},{"id":"ENSMUSP00000124570","abundance":0.536,"rank":13324,"name":"Adra1a","annotation":"Alpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity)."},{"id":"ENSMUSP00000063410","abundance":0.536,"rank":13325,"name":"Trim65","annotation":"Tripartite motif-containing protein 65."},{"id":"ENSMUSP00000034817","abundance":0.535,"rank":13326,"name":"Paqr5","annotation":"Membrane progestin receptor gamma; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation."},{"id":"ENSMUSP00000023390","abundance":0.535,"rank":13327,"name":"Drd3","annotation":"D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity); Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000159207","abundance":0.535,"rank":13328,"name":"LOC101055758","annotation":"Predicted gene 7592."},{"id":"ENSMUSP00000148147","abundance":0.534,"rank":13329,"name":"Gm29735","annotation":"Predicted gene, 29735."},{"id":"ENSMUSP00000070466","abundance":0.534,"rank":13330,"name":"Tagap1","annotation":"T-cell activation GTPase-activating protein 1."},{"id":"ENSMUSP00000055308","abundance":0.534,"rank":13331,"name":"Foxo1","annotation":"Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] "},{"id":"ENSMUSP00000142156","abundance":0.534,"rank":13332,"name":"Pcdha7","annotation":"Protocadherin alpha-7; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain."},{"id":"ENSMUSP00000043851","abundance":0.534,"rank":13333,"name":"Mtmr7","annotation":"Myotubularin-related protein 7; Phosphatase that specifically dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and inositol 1,3- bisphosphate (Ins(1,3)P2); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily."},{"id":"ENSMUSP00000121212","abundance":0.533,"rank":13334,"name":"Rfx8","annotation":"DNA-binding protein RFX8; May be a transcription factor; Belongs to the RFX family."},{"id":"ENSMUSP00000133841","abundance":0.533,"rank":13335,"name":"Vmn2r34","annotation":"Vomeronasal 2, receptor 34."},{"id":"ENSMUSP00000038203","abundance":0.533,"rank":13336,"name":"Cerk","annotation":"Ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8- dihydroceramide), to a lesser extent on C2-ceramide and C6- dihydroceramide, but not on other lipids, such as various sphingosines. Shows a greater preference for D-erythro isomer of ceramides (By similarity). Binds phosphoinositides (By similarity)."},{"id":"ENSMUSP00000151386","abundance":0.533,"rank":13337,"name":"Olfr1496","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000104688","abundance":0.532,"rank":13338,"name":"Gm14399","annotation":"Predicted gene 14399."},{"id":"ENSMUSP00000069652","abundance":0.532,"rank":13339,"name":"Tusc1","annotation":"Tumor suppressor candidate gene 1 protein homolog."},{"id":"ENSMUSP00000097882","abundance":0.532,"rank":13340,"name":"Alg10b","annotation":"Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase; Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N- linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol (By similarity). When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2 (By similarity). Has a role in maintenance of cochlear outer hair cell function."},{"id":"ENSMUSP00000008957","abundance":0.532,"rank":13341,"name":"Tppp2","annotation":"Tubulin polymerization-promoting protein family member 2; Probable regulator of microtubule dynamics required for sperm motility (Probable). In contrast to other members of the family, has no microtubule bundling activity (By similarity). Belongs to the TPPP family."},{"id":"ENSMUSP00000029795","abundance":0.532,"rank":13342,"name":"Rorc","annotation":"Nuclear receptor ROR-gamma; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respective [...] "},{"id":"ENSMUSP00000140811","abundance":0.531,"rank":13343,"name":"Ovol3","annotation":"Putative transcription factor ovo-like protein 3; May act as a transcription regulator; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000149360","abundance":0.53,"rank":13344,"name":"Olfr1049","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000150061","abundance":0.53,"rank":13345,"name":"Olfr1051","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000047413","abundance":0.53,"rank":13346,"name":"Nthl1","annotation":"Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family."},{"id":"ENSMUSP00000081013","abundance":0.53,"rank":13347,"name":"Dio2","annotation":"Type II iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development."},{"id":"ENSMUSP00000034510","abundance":0.53,"rank":13348,"name":"Nectin1","annotation":"Nectin-1; Involved in cell adhesion and synaptogegesis. Has some neurite outgrowth-promoting activity. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Belongs to the nectin family."},{"id":"ENSMUSP00000074542","abundance":0.53,"rank":13349,"name":"Olfr1185-ps1","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000057320","abundance":0.53,"rank":13350,"name":"Wdr72","annotation":"WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane."},{"id":"ENSMUSP00000129311","abundance":0.53,"rank":13351,"name":"Pex2","annotation":"Peroxisome biogenesis factor 2; Somewhat implicated in the biogenesis of peroxisomes; Belongs to the pex2/pex10/pex12 family."},{"id":"ENSMUSP00000028187","abundance":0.53,"rank":13352,"name":"Lamc3","annotation":"Laminin subunit gamma-3; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components."},{"id":"ENSMUSP00000030539","abundance":0.53,"rank":13353,"name":"Kif17","annotation":"Kinesin-like protein KIF17; Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules."},{"id":"ENSMUSP00000035515","abundance":0.529,"rank":13354,"name":"Pdcd7","annotation":"Programmed cell death protein 7; Promotes apoptosis when overexpressed."},{"id":"ENSMUSP00000068807","abundance":0.529,"rank":13355,"name":"Zfp248","annotation":"Zinc finger protein 248."},{"id":"ENSMUSP00000038616","abundance":0.529,"rank":13356,"name":"Plppr2","annotation":"Phospholipid phosphatase-related protein type 2."},{"id":"ENSMUSP00000053297","abundance":0.529,"rank":13357,"name":"Foxl2","annotation":"Forkhead box protein L2; Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans- differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2. Is a regulator of CYP19 expression. Is a transcriptional [...] "},{"id":"ENSMUSP00000032661","abundance":0.529,"rank":13358,"name":"Zfp819","annotation":"Zinc finger protein 819."},{"id":"ENSMUSP00000066556","abundance":0.529,"rank":13359,"name":"Soga1","annotation":"C-terminal 80 kDa form; Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. Belongs to the SOGA family."},{"id":"ENSMUSP00000057856","abundance":0.528,"rank":13360,"name":"Zbtb7c","annotation":"Zinc finger and BTB domain-containing protein 7C; May be a tumor suppressor gene."},{"id":"ENSMUSP00000008088","abundance":0.528,"rank":13361,"name":"Ttc9b","annotation":"Tetratricopeptide repeat protein 9B; Belongs to the TTC9 family."},{"id":"ENSMUSP00000130225","abundance":0.528,"rank":13362,"name":"Qrfprl","annotation":"Pyroglutamylated RFamide peptide receptor-like; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000050803","abundance":0.528,"rank":13363,"name":"Zfp235","annotation":"Zinc finger protein 235."},{"id":"ENSMUSP00000012426","abundance":0.528,"rank":13364,"name":"Wnt8a","annotation":"Protein Wnt-8a; Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning."},{"id":"ENSMUSP00000146043","abundance":0.528,"rank":13365,"name":"Zfp109","annotation":"Zinc finger protein ZFP109."},{"id":"ENSMUSP00000083810","abundance":0.528,"rank":13366,"name":"Myo18b","annotation":"Myosin XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family."},{"id":"ENSMUSP00000147331","abundance":0.527,"rank":13367,"name":"Gm40460","annotation":"Predicted gene, 39115."},{"id":"ENSMUSP00000035900","abundance":0.527,"rank":13368,"name":"Bmpr1a","annotation":"Bone morphogenetic protein receptor type-1A; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6 ; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily."},{"id":"ENSMUSP00000149648","abundance":0.527,"rank":13369,"name":"Olfr50","annotation":"Olfactory receptor 50; Odorant receptor. Activated by (+) and (-)-carvone. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000043101","abundance":0.526,"rank":13370,"name":"Tlr13","annotation":"Toll-like receptor 13; Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require add [...] "},{"id":"ENSMUSP00000050388","abundance":0.526,"rank":13371,"name":"Rnf149","annotation":"E3 ubiquitin-protein ligase RNF149; E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation."},{"id":"ENSMUSP00000006991","abundance":0.525,"rank":13372,"name":"Hcn1","annotation":"Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli."},{"id":"ENSMUSP00000105397","abundance":0.525,"rank":13373,"name":"Apol9b","annotation":"Apolipoprotein L 9b."},{"id":"ENSMUSP00000014691","abundance":0.525,"rank":13374,"name":"Wdfy2","annotation":"WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (By similarity). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin- stimulated AKT2 phosphorylation and glucose uptake and insulin- stimulated phosphorylation of AKT2  [...] "},{"id":"ENSMUSP00000025641","abundance":0.525,"rank":13375,"name":"Zp1","annotation":"Processed zona pellucida sperm-binding protein 1; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida."},{"id":"ENSMUSP00000013633","abundance":0.525,"rank":13376,"name":"Fgfrl1","annotation":"Fibroblast growth factor receptor-like 1; Has a negative effect on cell proliferation."},{"id":"ENSMUSP00000090697","abundance":0.525,"rank":13377,"name":"Fam83g","annotation":"Protein FAM83G; May regulate the bone morphogenetic proteins (BMP) pathway. Belongs to the FAM83 family."},{"id":"ENSMUSP00000029766","abundance":0.524,"rank":13378,"name":"Bcar3","annotation":"Breast cancer anti-estrogen resistance protein 3 homolog; Acts as an adapter protein downstream of several growth factor receptors to promote cell proliferation, migration, and redistribution of actin fibers. Specifically involved in INS/insulin signaling pathway by mediating MAPK1/ERK2-MAPK3/ERK1 activation and DNA synthesis (By similarity). Promotes insulin-mediated membrane ruffling (By similarity). In response to vasoconstrictor peptide EDN1, involved in the activation of RAP1 downstream of PTK2B via interaction with phosphorylated BCAR1. Inhibits cell migration and invasion via re [...] "},{"id":"ENSMUSP00000137770","abundance":0.524,"rank":13379,"name":"Rhbdd1","annotation":"Rhomboid-related protein 4; Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfe [...] "},{"id":"ENSMUSP00000154090","abundance":0.524,"rank":13380,"name":"Nek4","annotation":"Serine/threonine-protein kinase Nek4; Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage (By similarity). Protein kinase that seems to act exclusively upon threonine residues."},{"id":"ENSMUSP00000115237","abundance":0.523,"rank":13381,"name":"Sox3","annotation":"Transcription factor SOX-3; Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells."},{"id":"ENSMUSP00000096140","abundance":0.523,"rank":13382,"name":"Odf2l","annotation":"Protein BCAP; Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis."},{"id":"ENSMUSP00000035076","abundance":0.523,"rank":13383,"name":"Lrrc2","annotation":"Leucine-rich repeat-containing protein 2."},{"id":"ENSMUSP00000139144","abundance":0.522,"rank":13384,"name":"Efcab12","annotation":"EF-hand calcium-binding domain 12."},{"id":"ENSMUSP00000056993","abundance":0.522,"rank":13385,"name":"Oas1f","annotation":"2'-5' oligoadenylate synthetase 1F."},{"id":"ENSMUSP00000106693","abundance":0.521,"rank":13386,"name":"Ntsr2","annotation":"Neurotensin receptor type 2; Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily."},{"id":"ENSMUSP00000022698","abundance":0.521,"rank":13387,"name":"Dok2","annotation":"Docking protein 2; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation."},{"id":"ENSMUSP00000035240","abundance":0.521,"rank":13388,"name":"Thap3","annotation":"THAP domain-containing protein 3; Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1."},{"id":"ENSMUSP00000069456","abundance":0.521,"rank":13389,"name":"Timd4","annotation":"T-cell immunoglobulin and mucin domain-containing protein 4; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1. Belongs to the immunoglobulin superfamily. TIM family."},{"id":"ENSMUSP00000099579","abundance":0.521,"rank":13390,"name":"Chst14","annotation":"Carbohydrate sulfotransferase 14; Catalyzes the transfer of sulfate to position 4 of the N- acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may [...] "},{"id":"ENSMUSP00000052196","abundance":0.521,"rank":13391,"name":"Foxc1","annotation":"Forkhead box protein C1; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator. Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification. Acts  [...] "},{"id":"ENSMUSP00000131073","abundance":0.521,"rank":13392,"name":"Pcdh10","annotation":"Protocadherin 10."},{"id":"ENSMUSP00000073617","abundance":0.52,"rank":13393,"name":"Fbxw24","annotation":"F-box and WD-40 domain protein 24."},{"id":"ENSMUSP00000111568","abundance":0.52,"rank":13394,"name":"ENSMUSP00000111568","annotation":"annotation not available"},{"id":"ENSMUSP00000137582","abundance":0.52,"rank":13395,"name":"Ccl19-3","annotation":"C-C motif chemokine."},{"id":"ENSMUSP00000082689","abundance":0.52,"rank":13396,"name":"Grhl1","annotation":"Grainyhead-like protein 1 homolog; Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3 no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development. Belongs to the grh/CP2 family. Grainyhead subfamily."},{"id":"ENSMUSP00000135435","abundance":0.52,"rank":13397,"name":"Tirap","annotation":"Toll/interleukin-1 receptor domain-containing adapter protein; Adapter involved in the TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response (By similarity). Positively regulates the production of TNF-alpha and interleukin-6 (By similarity)."},{"id":"ENSMUSP00000025929","abundance":0.52,"rank":13398,"name":"Plaat5","annotation":"Phospholipase A and acyltransferase 5; Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which [...] "},{"id":"ENSMUSP00000098254","abundance":0.52,"rank":13399,"name":"4930503E14Rik","annotation":"RIKEN cDNA 4930503E14 gene."},{"id":"ENSMUSP00000128757","abundance":0.519,"rank":13400,"name":"Zfp703","annotation":"Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development."},{"id":"ENSMUSP00000000187","abundance":0.519,"rank":13401,"name":"Fgf6","annotation":"Fibroblast growth factor 6; Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration; Belongs to the heparin-binding growth factors family."},{"id":"ENSMUSP00000020552","abundance":0.519,"rank":13402,"name":"Tpgs1","annotation":"Tubulin polyglutamylase complex subunit 1; May act in the targeting of the tubulin polyglutamylase complex. Required for the development of the spermatid flagellum."},{"id":"ENSMUSP00000140251","abundance":0.519,"rank":13403,"name":"Ash1l","annotation":"Histone-lysine N-methyltransferase ASH1L; Histone methyltransferase specifically trimethylating 'Lys- 36' of histone H3 forming H3K36me3 (By similarity). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear (Probable)."},{"id":"ENSMUSP00000049346","abundance":0.519,"rank":13404,"name":"Xkr7","annotation":"XK-related protein 7."},{"id":"ENSMUSP00000022871","abundance":0.519,"rank":13405,"name":"Sdc2","annotation":"Syndecan-2; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis."},{"id":"ENSMUSP00000027015","abundance":0.519,"rank":13406,"name":"Casp1","annotation":"Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically  [...] "},{"id":"ENSMUSP00000053711","abundance":0.519,"rank":13407,"name":"Krtap4-7","annotation":"Keratin associated protein 4-7."},{"id":"ENSMUSP00000027214","abundance":0.518,"rank":13408,"name":"Ercc5","annotation":"DNA repair protein complementing XP-G cells homolog; Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription- coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too (By similarity). Belongs to the XPG/RAD2 endonuclease family. XPG subfamily."},{"id":"ENSMUSP00000037467","abundance":0.518,"rank":13409,"name":"Wdr93","annotation":"WD repeat-containing protein 93."},{"id":"ENSMUSP00000144529","abundance":0.518,"rank":13410,"name":"Oas1e","annotation":"2'-5' oligoadenylate synthetase 1E."},{"id":"ENSMUSP00000020909","abundance":0.518,"rank":13411,"name":"Laptm4a","annotation":"Lysosomal-associated transmembrane protein 4A; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment."},{"id":"ENSMUSP00000152353","abundance":0.518,"rank":13412,"name":"Zfhx3","annotation":"Zinc finger homeobox protein 3; Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (By similarity). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain. Regulator of myoblasts differentiation throug [...] "},{"id":"ENSMUSP00000008542","abundance":0.518,"rank":13413,"name":"Elk3","annotation":"ETS domain-containing protein Elk-3; May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element."},{"id":"ENSMUSP00000059654","abundance":0.517,"rank":13414,"name":"Dmrt2","annotation":"Doublesex- and mab-3-related transcription factor 2; Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome. Is not required for sex determination and/or differentiation in embryonic development. Also not involved in [...] "},{"id":"ENSMUSP00000039794","abundance":0.517,"rank":13415,"name":"Zfp40","annotation":"Zinc finger protein 40."},{"id":"ENSMUSP00000030773","abundance":0.517,"rank":13416,"name":"Xrcc2","annotation":"DNA repair protein XRCC2; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the Rad21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single [...] "},{"id":"ENSMUSP00000045684","abundance":0.517,"rank":13417,"name":"Zfp51","annotation":"Zinc finger protein 51."},{"id":"ENSMUSP00000062256","abundance":0.517,"rank":13418,"name":"Adrb2","annotation":"Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30- fold greater affinity than it does norepinephrine."},{"id":"ENSMUSP00000043346","abundance":0.517,"rank":13419,"name":"Mgat4b","annotation":"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis (By sim [...] "},{"id":"ENSMUSP00000044389","abundance":0.517,"rank":13420,"name":"Snx22","annotation":"Sorting nexin 22."},{"id":"ENSMUSP00000023059","abundance":0.517,"rank":13421,"name":"Dscc1","annotation":"Sister chromatid cohesion protein DCC1; Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3 (By similarity)."},{"id":"ENSMUSP00000072566","abundance":0.517,"rank":13422,"name":"Vmn2r37","annotation":"Vomeronasal 2, receptor 37."},{"id":"ENSMUSP00000028612","abundance":0.516,"rank":13423,"name":"Pamr1","annotation":"Inactive serine protease PAMR1; May play a role in regeneration of skeletal muscle; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000070112","abundance":0.516,"rank":13424,"name":"Yy2","annotation":"Transcription factor YY2; Functions as a multifunctional transcription factor that may exhibit positive and negative control on a large number of genes. May antagonize YY1 and function in development and differentiation."},{"id":"ENSMUSP00000118610","abundance":0.516,"rank":13425,"name":"Lpin2","annotation":"Phosphatidate phosphatase LPIN2; Plays important roles in controlling the metabolism of fatty acids at different levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism; Belongs to the lipin family."},{"id":"ENSMUSP00000134377","abundance":0.516,"rank":13426,"name":"Olfr309","annotation":"Olfactory receptor Olfr309."},{"id":"ENSMUSP00000069670","abundance":0.516,"rank":13427,"name":"Plpp2","annotation":"Phospholipid phosphatase 2; Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N- (9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioacti [...] "},{"id":"ENSMUSP00000037656","abundance":0.516,"rank":13428,"name":"Ehbp1l1","annotation":"EH domain-binding protein 1-like protein 1; May act as Rab effector protein and play a role in vesicle trafficking (By similarity). Involved in apical-directed transport in polarized epithelial cells; the functions seems to implicate Rab8, BIN1 and possibly DNM1."},{"id":"ENSMUSP00000099162","abundance":0.515,"rank":13429,"name":"Limk2","annotation":"LIM domain kinase 2; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro."},{"id":"ENSMUSP00000024620","abundance":0.515,"rank":13430,"name":"Riok2","annotation":"Serine/threonine-protein kinase RIO2; Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre- rRNA to the mature 18S rRNA. May regulate the timing of the metaphase- anaphase transition during mitotic progression, and its phosphorylation, may regulate this function."},{"id":"ENSMUSP00000019130","abundance":0.515,"rank":13431,"name":"Slfn3","annotation":"Slfn3 protein."},{"id":"ENSMUSP00000119468","abundance":0.515,"rank":13432,"name":"Tmem56","annotation":"TLC domain-containing protein 4; Belongs to the TLCD4 family."},{"id":"ENSMUSP00000060930","abundance":0.515,"rank":13433,"name":"Cdc42ep1","annotation":"Cdc42 effector protein 1; Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts (By similarity); Belongs to the BORG/CEP family."},{"id":"ENSMUSP00000060026","abundance":0.514,"rank":13434,"name":"Selenon","annotation":"Selenoprotein N; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity. Acts as a modulator of ryanodine receptor (RyR) activi [...] "},{"id":"ENSMUSP00000149901","abundance":0.514,"rank":13435,"name":"Olfr553","annotation":"Olfactory receptor Olfr553."},{"id":"ENSMUSP00000045252","abundance":0.514,"rank":13436,"name":"Tmem120a","annotation":"Transmembrane protein 120A; Necessary for efficient adipogenesis."},{"id":"ENSMUSP00000122915","abundance":0.514,"rank":13437,"name":"Kcnq2","annotation":"Potassium voltage-gated channel subfamily KQT member 2; Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability; Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.2/KCNQ2 sub-subfamily."},{"id":"ENSMUSP00000044400","abundance":0.514,"rank":13438,"name":"Plk5","annotation":"Inactive serine/threonine-protein kinase PLK5; Inactive serine/threonine-protein kinase that plays a role in cell cycle progression and neuronal differentiation."},{"id":"ENSMUSP00000103345","abundance":0.513,"rank":13439,"name":"Zfp652","annotation":"Zinc finger protein 652; Functions as a transcriptional repressor; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000045721","abundance":0.513,"rank":13440,"name":"Galnt12","annotation":"Polypeptide N-acetylgalactosaminyltransferase 12; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynth [...] "},{"id":"ENSMUSP00000148145","abundance":0.512,"rank":13441,"name":"Cebpd","annotation":"CCAAT/enhancer-binding protein delta; Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcription factor regulating the expression of genes involved in immune and inflammatory responses. Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (By similarity)."},{"id":"ENSMUSP00000149568","abundance":0.512,"rank":13442,"name":"Olfr352","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000052521","abundance":0.511,"rank":13443,"name":"Ankrd46","annotation":"Ankyrin repeat domain-containing protein 46."},{"id":"ENSMUSP00000124362","abundance":0.511,"rank":13444,"name":"Mroh8","annotation":"Maestro heat-like repeat family member 8."},{"id":"ENSMUSP00000129052","abundance":0.511,"rank":13445,"name":"Gm5799","annotation":"Predicted gene 5799."},{"id":"ENSMUSP00000087304","abundance":0.511,"rank":13446,"name":"Fam13a","annotation":"Protein FAM13A."},{"id":"ENSMUSP00000130290","abundance":0.511,"rank":13447,"name":"Rpp40","annotation":"Ribonuclease P protein subunit p40; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences."},{"id":"ENSMUSP00000104640","abundance":0.511,"rank":13448,"name":"Gm6710","annotation":"Predicted gene 14391."},{"id":"ENSMUSP00000104686","abundance":0.511,"rank":13449,"name":"Gm14391","annotation":"Predicted gene 14391."},{"id":"ENSMUSP00000071353","abundance":0.511,"rank":13450,"name":"Ccr1l1","annotation":"C-C chemokine receptor 1-like protein 1; Probable receptor for a C-C type chemokine."},{"id":"ENSMUSP00000080674","abundance":0.511,"rank":13451,"name":"Tas2r110","annotation":"Taste receptor type 2 member 110; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)."},{"id":"ENSMUSP00000043962","abundance":0.51,"rank":13452,"name":"Slc2a12","annotation":"Solute carrier family 2, facilitated glucose transporter member 12; Insulin-independent facilitative glucose transporter."},{"id":"ENSMUSP00000056245","abundance":0.51,"rank":13453,"name":"Clrn3","annotation":"Clarin-3."},{"id":"ENSMUSP00000064046","abundance":0.51,"rank":13454,"name":"Ptprn2","annotation":"Receptor-type tyrosine-protein phosphatase N2; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones [...] "},{"id":"ENSMUSP00000059261","abundance":0.51,"rank":13455,"name":"Pcmtd1","annotation":"Protein-L-isoaspartate O-methyltransferase domain-containing protein 1."},{"id":"ENSMUSP00000050971","abundance":0.51,"rank":13456,"name":"Trex1","annotation":"Three-prime repair exonuclease 1; Major cellular 3'-to-5' DNA exonuclease which digests single- stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the pr [...] "},{"id":"ENSMUSP00000021490","abundance":0.51,"rank":13457,"name":"Serpina1f","annotation":"Alpha-1-antitrypsin 1-6; Inhibitor of serine proteases. Belongs to the serpin family."},{"id":"ENSMUSP00000043250","abundance":0.51,"rank":13458,"name":"Fras1","annotation":"Extracellular matrix protein FRAS1; Belongs to the FRAS1 family."},{"id":"ENSMUSP00000093097","abundance":0.509,"rank":13459,"name":"Adamtsl5","annotation":"ADAMTS-like 5."},{"id":"ENSMUSP00000110696","abundance":0.509,"rank":13460,"name":"Muc13","annotation":"Mucin-13; Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling."},{"id":"ENSMUSP00000039484","abundance":0.509,"rank":13461,"name":"Ankmy2","annotation":"Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia."},{"id":"ENSMUSP00000070209","abundance":0.509,"rank":13462,"name":"Rpap2","annotation":"Putative RNA polymerase II subunit B1 CTD phosphatase Rpap2; Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes; Belongs to the RPAP2 family."},{"id":"ENSMUSP00000124179","abundance":0.509,"rank":13463,"name":"Filip1l","annotation":"Filamin A-interacting protein 1-like; Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor-associated vasculature (By similarity)."},{"id":"ENSMUSP00000131300","abundance":0.509,"rank":13464,"name":"Skint3","annotation":"Selection and upkeep of intraepithelial T-cells protein 3; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus."},{"id":"ENSMUSP00000034775","abundance":0.508,"rank":13465,"name":"Fem1b","annotation":"Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity); Belongs to the fem-1 family."},{"id":"ENSMUSP00000053972","abundance":0.508,"rank":13466,"name":"Drc7","annotation":"Dynein regulatory complex subunit 7; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility."},{"id":"ENSMUSP00000101079","abundance":0.508,"rank":13467,"name":"Lrrtm3","annotation":"Leucine-rich repeat transmembrane neuronal protein 3; May play a role in the development and maintenance of the vertebrate nervous system. Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity); Belongs to the LRRTM family."},{"id":"ENSMUSP00000097493","abundance":0.508,"rank":13468,"name":"Olfr1040","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000075467","abundance":0.508,"rank":13469,"name":"Speer4f1","annotation":"Spermatogenesis-associated glutamate (E)-rich protein 4F1."},{"id":"ENSMUSP00000129484","abundance":0.508,"rank":13470,"name":"Zfp111","annotation":"Zinc finger protein ZFP111."},{"id":"ENSMUSP00000025388","abundance":0.507,"rank":13471,"name":"Ftmt","annotation":"Ferritin, mitochondrial; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity); Belongs to the ferritin family."},{"id":"ENSMUSP00000150801","abundance":0.507,"rank":13472,"name":"Olfr341","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000122895","abundance":0.507,"rank":13473,"name":"Aanat","annotation":"Serotonin N-acetyltransferase; Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin."},{"id":"ENSMUSP00000056340","abundance":0.507,"rank":13474,"name":"Zfp280b","annotation":"Zinc finger protein 280B."},{"id":"ENSMUSP00000151882","abundance":0.507,"rank":13475,"name":"Olfr452","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000020381","abundance":0.507,"rank":13476,"name":"Frs2","annotation":"Fibroblast growth factor receptor substrate 2; Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1."},{"id":"ENSMUSP00000150773","abundance":0.507,"rank":13477,"name":"Olfr853","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000088098","abundance":0.506,"rank":13478,"name":"Harbi1","annotation":"Putative nuclease HARBI1; Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity (By similarity). Belongs to the HARBI1 family."},{"id":"ENSMUSP00000078786","abundance":0.506,"rank":13479,"name":"Klk1b27","annotation":"Kallikrein 1-related peptidase b27; Serine protease with chymotrypsin-like cleavage specificity. Shows activity towards casein, gelatin, IGFBP3 and fibronectin but not towards laminin or collagens I and IV. Does not hydrolyze kininogin to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000000208","abundance":0.506,"rank":13480,"name":"Slfn4","annotation":"Schlafen 4."},{"id":"ENSMUSP00000079812","abundance":0.506,"rank":13481,"name":"Zfp28","annotation":"Zinc finger protein 28; May be involved in transcriptional regulation. May have a role in embryonic development."},{"id":"ENSMUSP00000078369","abundance":0.506,"rank":13482,"name":"Aspg","annotation":"1-alkyl-2-acetylglycerophosphocholine esterase; Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero- 3-phosphocholine (1-acyl-GPC) to the sn-1(3) positions of glycerol and 2-acylglycerol (sn-1 to -1(3) transfer), (2) acyl transfer from 1-acyl- GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3- phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 po [...] "},{"id":"ENSMUSP00000113317","abundance":0.506,"rank":13483,"name":"Nrip2","annotation":"Nuclear receptor-interacting protein 2; Down-regulates transcriptional activation by nuclear receptors, such as NR1F2."},{"id":"ENSMUSP00000096399","abundance":0.506,"rank":13484,"name":"Crxos","annotation":"Cone-rod homeobox, opposite strand."},{"id":"ENSMUSP00000075794","abundance":0.506,"rank":13485,"name":"Nlrp4e","annotation":"NACHT, LRR and PYD domains-containing protein 4E; May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors."},{"id":"ENSMUSP00000038139","abundance":0.506,"rank":13486,"name":"Rskr","annotation":"Ribosomal protein S6 kinase-related protein; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family."},{"id":"ENSMUSP00000149592","abundance":0.506,"rank":13487,"name":"Olfr293","annotation":"Olfactory receptor Olfr293."},{"id":"ENSMUSP00000042676","abundance":0.506,"rank":13488,"name":"Rmi2","annotation":"RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM."},{"id":"ENSMUSP00000036628","abundance":0.506,"rank":13489,"name":"Sdr9c7","annotation":"Short-chain dehydrogenase/reductase family 9C member 7; Displays weak conversion of all-trans-retinal to all-trans- retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity (By similarity)."},{"id":"ENSMUSP00000045542","abundance":0.506,"rank":13490,"name":"Tspyl5","annotation":"Testis-specific Y-encoded-like protein 5; Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7 (By similarity); Belongs to the nucleosome assembly protein (NAP) family."},{"id":"ENSMUSP00000116886","abundance":0.505,"rank":13491,"name":"Pcdh19","annotation":"Protocadherin-19; Potential calcium-dependent cell-adhesion protein."},{"id":"ENSMUSP00000120015","abundance":0.505,"rank":13492,"name":"Gpr137c","annotation":"G protein-coupled receptor 137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes."},{"id":"ENSMUSP00000043466","abundance":0.505,"rank":13493,"name":"Agap2","annotation":"Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase (By similarity); Belongs to the centaurin gamma-like family."},{"id":"ENSMUSP00000043844","abundance":0.505,"rank":13494,"name":"Zyg11b","annotation":"Protein zyg-11 homolog B; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZER1 to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation."},{"id":"ENSMUSP00000043477","abundance":0.505,"rank":13495,"name":"St8sia4","annotation":"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase; Catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid (PSA), which is present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells."},{"id":"ENSMUSP00000151738","abundance":0.505,"rank":13496,"name":"Olfr1183","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000001712","abundance":0.505,"rank":13497,"name":"Cabin1","annotation":"Calcineurin-binding protein 1."},{"id":"ENSMUSP00000135642","abundance":0.505,"rank":13498,"name":"Rgsl1","annotation":"Regulator of G-protein-signaling-like 1."},{"id":"ENSMUSP00000149335","abundance":0.505,"rank":13499,"name":"Ncoa7","annotation":"Nuclear receptor coactivator 7; Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA (By similarity)."},{"id":"ENSMUSP00000103575","abundance":0.504,"rank":13500,"name":"Atp8b5","annotation":"Phospholipid-transporting ATPase FetA; P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May play a role in phospholid transport across membranes and in acrosome formation; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily."},{"id":"ENSMUSP00000097721","abundance":0.504,"rank":13501,"name":"Rc3h2","annotation":"Roquin-2; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimul [...] "},{"id":"ENSMUSP00000095461","abundance":0.504,"rank":13502,"name":"Zpld2","annotation":"Zona pellucida-like domain-containing 2."},{"id":"ENSMUSP00000101531","abundance":0.504,"rank":13503,"name":"Gpr3","annotation":"G-protein coupled receptor 3; Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid- beta peptide generation in neurons (By similarity) and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000146544","abundance":0.504,"rank":13504,"name":"Mical3","annotation":"[F-actin]-monooxygenase MICAL3; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for [...] "},{"id":"ENSMUSP00000107337","abundance":0.504,"rank":13505,"name":"Lmntd1","annotation":"Lamin tail domain-containing protein 1; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000018710","abundance":0.504,"rank":13506,"name":"Slc2a4","annotation":"Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell ; Belongs to the major facilitator superfamily. Sugar transporte [...] "},{"id":"ENSMUSP00000153717","abundance":0.504,"rank":13507,"name":"Wdr27","annotation":"WD repeat-containing protein 27."},{"id":"ENSMUSP00000105363","abundance":0.503,"rank":13508,"name":"Mast1","annotation":"Microtubule-associated serine/threonine-protein kinase 1; Microtubule-associated protein essential for correct brain development. Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family."},{"id":"ENSMUSP00000116231","abundance":0.503,"rank":13509,"name":"Adgrb3","annotation":"Adhesion G protein-coupled receptor B3; Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity. Promotes myoblast fusion through ELMO/DOCK1 (By similarity). Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily."},{"id":"ENSMUSP00000129818","abundance":0.503,"rank":13510,"name":"Speer4f2","annotation":"Spermatogenesis-associated glutamate (E)-rich protein 4f2."},{"id":"ENSMUSP00000017151","abundance":0.503,"rank":13511,"name":"Rbpjl","annotation":"Recombining binding protein suppressor of hairless-like protein; Putative transcription factor, which cooperates with EBNA2 to activate transcription; Belongs to the Su(H) family."},{"id":"ENSMUSP00000113283","abundance":0.503,"rank":13512,"name":"Hecw2","annotation":"E3 ubiquitin-protein ligase HECW2; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73. Involved in the regulation of mitotic metaphase/anaphase transition."},{"id":"ENSMUSP00000112688","abundance":0.503,"rank":13513,"name":"Samd9l","annotation":"Sterile alpha motif domain-containing protein 9-like; May be involved in endosome fusion. Mediates down-regulation of growth factor signaling via internalization of growth factor receptors."},{"id":"ENSMUSP00000119049","abundance":0.503,"rank":13514,"name":"D3Ertd751e","annotation":"UPF0462 protein C4orf33 homolog."},{"id":"ENSMUSP00000105705","abundance":0.502,"rank":13515,"name":"Kcnn1","annotation":"Small conductance calcium-activated potassium channel protein 1; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity)."},{"id":"ENSMUSP00000021120","abundance":0.501,"rank":13516,"name":"Trim47","annotation":"E3 ubiquitin-protein ligase TRIM47; E3 ubiquitin-protein ligase that mediates the ubiquitination and proteasomal degradation of CYLD; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000068790","abundance":0.501,"rank":13517,"name":"Zzef1","annotation":"Zinc finger ZZ-type and EF-hand domain-containing protein 1."},{"id":"ENSMUSP00000024928","abundance":0.501,"rank":13518,"name":"Prss21","annotation":"Testisin; Could regulate proteolytic events associated with testicular germ cell maturation; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000032462","abundance":0.501,"rank":13519,"name":"Timp4","annotation":"Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor."},{"id":"ENSMUSP00000138000","abundance":0.501,"rank":13520,"name":"Cxxc4","annotation":"CXXC-type zinc finger protein 4; Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated- hydroxymethyl-CpG (By similarity)."},{"id":"ENSMUSP00000024914","abundance":0.5,"rank":13521,"name":"Themis3","annotation":"Protein THEMIS3."},{"id":"ENSMUSP00000089148","abundance":0.5,"rank":13522,"name":"Aopep","annotation":"Aminopeptidase O; Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart."},{"id":"ENSMUSP00000128464","abundance":0.5,"rank":13523,"name":"Mast4","annotation":"Microtubule-associated serine/threonine-protein kinase 4."},{"id":"ENSMUSP00000032180","abundance":0.5,"rank":13524,"name":"Wnt7a","annotation":"Protein Wnt-7a; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway. Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation i [...] "},{"id":"ENSMUSP00000133212","abundance":0.5,"rank":13525,"name":"Zfp641","annotation":"Zinc finger protein 641; Transcriptional activator. Activates transcriptional activities of SRE and AP-1 (By similarity)."},{"id":"ENSMUSP00000074864","abundance":0.499,"rank":13526,"name":"Btbd3","annotation":"BTB/POZ domain-containing protein 3; Acts as a key regulator of dendritic field orientation during development of sensory cortex. Also directs dendrites toward active axon terminals when ectopically expressed."},{"id":"ENSMUSP00000146241","abundance":0.498,"rank":13527,"name":"Zfp114","annotation":"Zinc finger protein 114."},{"id":"ENSMUSP00000157323","abundance":0.498,"rank":13528,"name":"Ccdc178","annotation":"Coiled-coil domain-containing protein 178."},{"id":"ENSMUSP00000145822","abundance":0.498,"rank":13529,"name":"Olfr43","annotation":"Olfactory receptor Olfr43."},{"id":"ENSMUSP00000118361","abundance":0.498,"rank":13530,"name":"Zfp407","annotation":"Zinc finger protein 407."},{"id":"ENSMUSP00000036110","abundance":0.498,"rank":13531,"name":"Poln","annotation":"DNA polymerase nu; DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity. Error-prone DNA polymerase that preferentially misincorporates dT regardless of templ [...] "},{"id":"ENSMUSP00000000384","abundance":0.498,"rank":13532,"name":"Trappc10","annotation":"Trafficking protein particle complex subunit 10; May play a role in vesicular transport from endoplasmic reticulum to Golgi."},{"id":"ENSMUSP00000028469","abundance":0.498,"rank":13533,"name":"Slc43a1","annotation":"Large neutral amino acids transporter small subunit 3; Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine (By similarity); Belongs to the SLC43A transporter (TC 2.A.1.44) family."},{"id":"ENSMUSP00000150146","abundance":0.497,"rank":13534,"name":"Olfr1418","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000028829","abundance":0.497,"rank":13535,"name":"Spred1","annotation":"Sprouty-related, EVH1 domain-containing protein 1; Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow."},{"id":"ENSMUSP00000104785","abundance":0.497,"rank":13536,"name":"Tshz2","annotation":"Teashirt homolog 2; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential)."},{"id":"ENSMUSP00000102346","abundance":0.497,"rank":13537,"name":"BC051019","annotation":"Uncharacterized protein C11orf16 homolog."},{"id":"ENSMUSP00000019901","abundance":0.497,"rank":13538,"name":"Ccdc170","annotation":"Coiled-coil domain-containing 170."},{"id":"ENSMUSP00000044734","abundance":0.497,"rank":13539,"name":"Zdhhc9","annotation":"Palmitoyltransferase ZDHHC9; The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS."},{"id":"ENSMUSP00000125139","abundance":0.497,"rank":13540,"name":"Mfap3l","annotation":"Microfibrillar-associated protein 3-like; May participate in the nuclear signaling of EGFR and MAPK1/ERK2."},{"id":"ENSMUSP00000062967","abundance":0.497,"rank":13541,"name":"Stkld1","annotation":"Serine/threonine kinase-like domain-containing protein STKLD1."},{"id":"ENSMUSP00000065619","abundance":0.496,"rank":13542,"name":"Rasgef1c","annotation":"Ras-GEF domain-containing family member 1C; Guanine nucleotide exchange factor (GEF)."},{"id":"ENSMUSP00000136714","abundance":0.496,"rank":13543,"name":"Ccdc180","annotation":"Coiled-coil domain-containing 180."},{"id":"ENSMUSP00000025020","abundance":0.496,"rank":13544,"name":"Rgs11","annotation":"Regulator of G-protein signaling 11; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form."},{"id":"ENSMUSP00000054233","abundance":0.496,"rank":13545,"name":"P2rx2","annotation":"P2X purinoceptor 2; Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family."},{"id":"ENSMUSP00000044262","abundance":0.496,"rank":13546,"name":"Ap4b1","annotation":"AP-4 complex subunit beta-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (By similarity). It is also involved in protein sorting to the basolateral membrane in epithelial cells a [...] "},{"id":"ENSMUSP00000059896","abundance":0.495,"rank":13547,"name":"Slc29a4","annotation":"Equilibrative nucleoside transporter 4; Functions as a polyspecific organic cation transporter, efficiently transporting many organic cations such as monoamine neurotransmitters 1-methyl-4-phenylpyridinium and biogenic amines including serotonin, dopamine, norepinephrine and epinephrine. May play a role in regulating central nervous system homeostasis of monoamine neurotransmitters. May be involved in luminal transport of organic cations in the kidney and seems to use luminal proton gradient to drive organic cation reabsorptprev reabsorption. Does not seem to transport nucleoside and n [...] "},{"id":"ENSMUSP00000039660","abundance":0.495,"rank":13548,"name":"Fzd8","annotation":"Frizzled-8; Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes (By similarity). The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can  [...] "},{"id":"ENSMUSP00000015796","abundance":0.495,"rank":13549,"name":"Steap1","annotation":"Metalloreductase STEAP1; Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family."},{"id":"ENSMUSP00000005815","abundance":0.494,"rank":13550,"name":"Kit","annotation":"Mast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] "},{"id":"ENSMUSP00000082995","abundance":0.494,"rank":13551,"name":"Map4k1","annotation":"Mitogen-activated protein kinase kinase kinase kinase 1; Serine/threonine-protein kinase, which may play a role in the response to environmental stress (By similarity). Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily."},{"id":"ENSMUSP00000066607","abundance":0.494,"rank":13552,"name":"Phtf1","annotation":"Putative homeodomain transcription factor 1; May play a role in transcription regulation."},{"id":"ENSMUSP00000033905","abundance":0.494,"rank":13553,"name":"Ankrd10","annotation":"Ankyrin repeat domain-containing protein 10."},{"id":"ENSMUSP00000057521","abundance":0.494,"rank":13554,"name":"B3galt6","annotation":"Beta-1,3-galactosyltransferase 6; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Has a preference for galactose-beta-1,4-xylose that is found in the linker region of glycosaminoglycans, such as heparan sulfate and chondroitin sulfate. Has no activity towards substrates with terminal glucosamine or galactosamine residues (By similarity); Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000100673","abundance":0.493,"rank":13555,"name":"Krtap9-5","annotation":"Keratin-associated protein 9-5."},{"id":"ENSMUSP00000035649","abundance":0.493,"rank":13556,"name":"Clvs1","annotation":"Clavesin-1; Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity)."},{"id":"ENSMUSP00000004294","abundance":0.493,"rank":13557,"name":"Kifc2","annotation":"Kinesin-like protein KIFC2; May play a role in microtubule-dependent retrograde axonal transport. May function as the motor for the transport of multivesicular body (MVB)-like organelles in dendrites; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family."},{"id":"ENSMUSP00000031455","abundance":0.493,"rank":13558,"name":"Mfsd7a","annotation":"Solute carrier family 49 member A3."},{"id":"ENSMUSP00000062615","abundance":0.493,"rank":13559,"name":"Ppp1r16b","annotation":"Protein phosphatase 1 regulatory inhibitor subunit 16B; Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of the PI3K/AKT signaling pathway (By similarity). Involved in the regulation of angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Involved in the regulation of endothelial cell filopodia extension (By sim [...] "},{"id":"ENSMUSP00000094966","abundance":0.493,"rank":13560,"name":"Pknox1","annotation":"Homeobox protein PKNOX1; Activates transcription in the presence of PBX1A and HOXA1. Belongs to the TALE/MEIS homeobox family."},{"id":"ENSMUSP00000091312","abundance":0.493,"rank":13561,"name":"Cep70","annotation":"Centrosomal protein of 70 kDa; Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle (By similarity)."},{"id":"ENSMUSP00000041308","abundance":0.493,"rank":13562,"name":"Zc3h7a","annotation":"Zinc finger CCCH type-containing 7 A."},{"id":"ENSMUSP00000025850","abundance":0.493,"rank":13563,"name":"Fosl1","annotation":"Fos-related antigen 1; Belongs to the bZIP family. Fos subfamily."},{"id":"ENSMUSP00000058405","abundance":0.492,"rank":13564,"name":"Lmbr1","annotation":"Limb region 1 protein; Putative membrane receptor."},{"id":"ENSMUSP00000108397","abundance":0.492,"rank":13565,"name":"Dcp1b","annotation":"mRNA-decapping enzyme 1B; May play a role in the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. May remove the 7- methyl guanine cap structure from mRNA molecules, yielding a 5'- phosphorylated mRNA fragment and 7m-GDP (By similarity); Belongs to the DCP1 family."},{"id":"ENSMUSP00000146983","abundance":0.492,"rank":13566,"name":"Frmpd3","annotation":"FERM and PDZ domain-containing 3."},{"id":"ENSMUSP00000044078","abundance":0.492,"rank":13567,"name":"Pnpla7","annotation":"Patatin-like phospholipase domain-containing protein 7; Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy (By similarity). Isoform 1 and isoform 2 have equal enzyme activity. Isoform 3 has no enzyme activity; Belongs to the NTE family."},{"id":"ENSMUSP00000077232","abundance":0.492,"rank":13568,"name":"Mllt3","annotation":"Protein AF-9; Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acylated histone H3, with a marked preference for histone H3 that is crotonylated. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. Recognizes and binds histone H3 crotonylated at 'Lys-9' (H3K9cr), and with slightly lower affinity histone H3 crotonylate [...] "},{"id":"ENSMUSP00000088670","abundance":0.492,"rank":13569,"name":"Frem2","annotation":"FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs ; Belongs to the FRAS1 family."},{"id":"ENSMUSP00000033163","abundance":0.492,"rank":13570,"name":"Mettl9","annotation":"Methyltransferase-like protein 9."},{"id":"ENSMUSP00000017549","abundance":0.492,"rank":13571,"name":"Nek8","annotation":"Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway."},{"id":"ENSMUSP00000153183","abundance":0.492,"rank":13572,"name":"Trappc8","annotation":"Trafficking protein particle complex 8."},{"id":"ENSMUSP00000073082","abundance":0.492,"rank":13573,"name":"Fam120c","annotation":"Constitutive coactivator of PPAR-gamma-like protein 2."},{"id":"ENSMUSP00000030439","abundance":0.492,"rank":13574,"name":"Rnf220","annotation":"E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity)."},{"id":"ENSMUSP00000074729","abundance":0.491,"rank":13575,"name":"Plekhg3","annotation":"Pleckstrin homology domain-containing family G member 3."},{"id":"ENSMUSP00000054990","abundance":0.491,"rank":13576,"name":"Nhlrc1","annotation":"E3 ubiquitin-protein ligase NHLRC1; E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin- dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen [...] "},{"id":"ENSMUSP00000127700","abundance":0.491,"rank":13577,"name":"Tifa","annotation":"TRAF-interacting protein with FHA domain-containing protein A; Adapter molecule that plays a key role in the activation of proinflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome- independent mechanism (By similarity). TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP- Heptose), a potent PAMP  [...] "},{"id":"ENSMUSP00000067783","abundance":0.491,"rank":13578,"name":"Fzd5","annotation":"Frizzled-5; Receptor for Wnt proteins. Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed. In neurons, activation of WNT7A promotes formation of synapses (By similarity). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium  [...] "},{"id":"ENSMUSP00000064332","abundance":0.491,"rank":13579,"name":"Exoc6","annotation":"Exocyst complex component 6; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis; Belongs to the SEC15 family."},{"id":"ENSMUSP00000132366","abundance":0.491,"rank":13580,"name":"Apold1","annotation":"Apolipoprotein L domain-containing 1."},{"id":"ENSMUSP00000030714","abundance":0.491,"rank":13581,"name":"Sema3a","annotation":"Semaphorin-3A; Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally. Involved in the development of the olfactory system and in neuronal control of puberty (By similarity). Belongs to the semaphorin family."},{"id":"ENSMUSP00000028105","abundance":0.49,"rank":13582,"name":"Mindy3","annotation":"Ubiquitin carboxyl-terminal hydrolase MINDY-3; Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins."},{"id":"ENSMUSP00000114668","abundance":0.49,"rank":13583,"name":"Gm14410","annotation":"Predicted gene 14410."},{"id":"ENSMUSP00000132528","abundance":0.49,"rank":13584,"name":"Adcy7","annotation":"Adenylate cyclase type 7; Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated n [...] "},{"id":"ENSMUSP00000035090","abundance":0.49,"rank":13585,"name":"Fbxl2","annotation":"F-box/LRR-repeat protein 2; Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degrad [...] "},{"id":"ENSMUSP00000092748","abundance":0.49,"rank":13586,"name":"Gm136","annotation":"Uncharacterized protein C6orf163 homolog."},{"id":"ENSMUSP00000113912","abundance":0.49,"rank":13587,"name":"Sgcz","annotation":"Zeta-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. May play a role in the maintenance of striated muscle membrane stability."},{"id":"ENSMUSP00000049248","abundance":0.49,"rank":13588,"name":"Tulp4","annotation":"Tubby-related protein 4; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the TUB family."},{"id":"ENSMUSP00000012580","abundance":0.489,"rank":13589,"name":"Hps3","annotation":"Hermansky-Pudlak syndrome 3 protein homolog; Involved in early stages of melanosome biogenesis and maturation."},{"id":"ENSMUSP00000038430","abundance":0.489,"rank":13590,"name":"Snx13","annotation":"Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family."},{"id":"ENSMUSP00000153189","abundance":0.489,"rank":13591,"name":"Rin1","annotation":"Ras and Rab interactor 1; Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity). Belongs to the RIN (Ras int [...] "},{"id":"ENSMUSP00000093325","abundance":0.488,"rank":13592,"name":"Tmf1","annotation":"TATA element modulatory factor; Potential coactivator of the androgen receptor. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER (By similarity). Mediates STAT3 degradation."},{"id":"ENSMUSP00000043240","abundance":0.488,"rank":13593,"name":"Vps13d","annotation":"Vacuolar protein sorting 13D."},{"id":"ENSMUSP00000031901","abundance":0.488,"rank":13594,"name":"Trpv5","annotation":"Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit [...] "},{"id":"ENSMUSP00000151174","abundance":0.488,"rank":13595,"name":"Olfr1179","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000109975","abundance":0.488,"rank":13596,"name":"Tprn","annotation":"Taperin; Belongs to the taperin family."},{"id":"ENSMUSP00000062995","abundance":0.487,"rank":13597,"name":"Dnah10","annotation":"Dynein, axonemal, heavy chain 10."},{"id":"ENSMUSP00000071870","abundance":0.487,"rank":13598,"name":"Olfr1329","annotation":"Olfactory receptor 1329."},{"id":"ENSMUSP00000102479","abundance":0.487,"rank":13599,"name":"Hbb-bh2","annotation":"Predicted gene, EG436003; Belongs to the globin family."},{"id":"ENSMUSP00000065645","abundance":0.487,"rank":13600,"name":"Taf7","annotation":"Transcription initiation factor TFIID subunit 7; Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively)."},{"id":"ENSMUSP00000033275","abundance":0.487,"rank":13601,"name":"Tex36","annotation":"Testis-expressed 36."},{"id":"ENSMUSP00000001347","abundance":0.487,"rank":13602,"name":"Rnd2","annotation":"Rho-related GTP-binding protein RhoN; May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity); Belongs to the small GTPase superfamily. Rho family."},{"id":"ENSMUSP00000067734","abundance":0.487,"rank":13603,"name":"Tas2r144","annotation":"Taste receptor type 2 member 40; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)."},{"id":"ENSMUSP00000150534","abundance":0.487,"rank":13604,"name":"Olfr796","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000102191","abundance":0.486,"rank":13605,"name":"Cd300lb","annotation":"CMRF35-like molecule 7; Acts as an activating immune receptor in mast cells through its interaction with ITAM-bearing adapter TYROBP."},{"id":"ENSMUSP00000051492","abundance":0.486,"rank":13606,"name":"Setx","annotation":"Probable helicase senataxin; Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription. Contributes to the mRNA splicing efficiency and splice site selection. Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA a [...] "},{"id":"ENSMUSP00000050582","abundance":0.486,"rank":13607,"name":"Ccdc63","annotation":"Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads."},{"id":"ENSMUSP00000021567","abundance":0.486,"rank":13608,"name":"Pcnx","annotation":"Pecanex-like protein 1; Belongs to the pecanex family."},{"id":"ENSMUSP00000142293","abundance":0.486,"rank":13609,"name":"Pcdha5","annotation":"Protocadherin alpha 5."},{"id":"ENSMUSP00000117778","abundance":0.486,"rank":13610,"name":"Nsd3","annotation":"Histone-lysine N-methyltransferase NSD3; Histone methyltransferase. Preferentially dimethylates 'Lys- 4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily."},{"id":"ENSMUSP00000154334","abundance":0.486,"rank":13611,"name":"Vmn1r17","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000076851","abundance":0.486,"rank":13612,"name":"Obp2a","annotation":"Odorant-binding protein 2a; May play a role in male fertility. May act as a retinoid carrier protein within the epididymis."},{"id":"ENSMUSP00000058951","abundance":0.485,"rank":13613,"name":"Angptl8","annotation":"Angiopoietin-like protein 8; Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3. Belongs to the ANGPTL8 family."},{"id":"ENSMUSP00000048063","abundance":0.485,"rank":13614,"name":"Tspoap1","annotation":"Peripheral-type benzodiazepine receptor-associated protein 1; Belongs to the RIMBP family."},{"id":"ENSMUSP00000049128","abundance":0.485,"rank":13615,"name":"Cul7","annotation":"Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] "},{"id":"ENSMUSP00000063264","abundance":0.485,"rank":13616,"name":"Tmcc3","annotation":"Transmembrane and coiled-coil domain protein 3; Belongs to the TEX28 family."},{"id":"ENSMUSP00000077596","abundance":0.485,"rank":13617,"name":"Sp7","annotation":"Transcription factor Sp7; Transcriptional activator essential for osteoblast differentiation. Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences. Belongs to the Sp1 C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000129466","abundance":0.484,"rank":13618,"name":"Vmn2r45","annotation":"Vomeronasal 2, receptor 45."},{"id":"ENSMUSP00000091831","abundance":0.484,"rank":13619,"name":"Zbtb18","annotation":"Zinc finger and BTB domain-containing protein 18; Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. May  [...] "},{"id":"ENSMUSP00000049331","abundance":0.484,"rank":13620,"name":"Rnf13","annotation":"E3 ubiquitin-protein ligase RNF13; E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity)."},{"id":"ENSMUSP00000022720","abundance":0.484,"rank":13621,"name":"Fbxl3","annotation":"F-box/LRR-repeat protein 3; Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex."},{"id":"ENSMUSP00000073984","abundance":0.484,"rank":13622,"name":"Tex33","annotation":"Testis-expressed protein 33."},{"id":"ENSMUSP00000025719","abundance":0.484,"rank":13623,"name":"Mlana","annotation":"Melan-A."},{"id":"ENSMUSP00000082882","abundance":0.483,"rank":13624,"name":"Spdye4a","annotation":"Speedy protein E4A; Promotes progression through the cell cycle via binding and activation of CDK1; Belongs to the Speedy/Ringo family."},{"id":"ENSMUSP00000114074","abundance":0.483,"rank":13625,"name":"Sgk1","annotation":"Serine/threonine-protein kinase Sgk1; Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peri [...] "},{"id":"ENSMUSP00000034325","abundance":0.483,"rank":13626,"name":"Lpar2","annotation":"Lysophosphatidic acid receptor 2; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation (By similarity)."},{"id":"ENSMUSP00000034225","abundance":0.483,"rank":13627,"name":"Cntnap4","annotation":"Contactin-associated protein-like 4; Presynaptic protein involved in both dopaminergic synaptic transmission and GABAergic system, thereby participating in the structural maturation of inhibitory interneuron synapses. Involved in the dopaminergic synaptic transmission by attenuating dopamine release through a presynaptic mechanism. Also participates in the GABAergic system."},{"id":"ENSMUSP00000105984","abundance":0.483,"rank":13628,"name":"Prl8a6","annotation":"Prolactin-8A6; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000014022","abundance":0.483,"rank":13629,"name":"Rnf170","annotation":"E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells."},{"id":"ENSMUSP00000153132","abundance":0.483,"rank":13630,"name":"Syt7","annotation":"Synaptotagmin-7."},{"id":"ENSMUSP00000130160","abundance":0.482,"rank":13631,"name":"Vmn2r47","annotation":"Vomeronasal 2, receptor 47."},{"id":"ENSMUSP00000159160","abundance":0.482,"rank":13632,"name":"Gm10302","annotation":"Predicted gene 10302."},{"id":"ENSMUSP00000070130","abundance":0.482,"rank":13633,"name":"Nepn","annotation":"Nephrocan; May inhibit TGF-beta signaling."},{"id":"ENSMUSP00000023265","abundance":0.482,"rank":13634,"name":"Psca","annotation":"Prostate stem cell antigen; May be involved in the regulation of cell proliferation."},{"id":"ENSMUSP00000022601","abundance":0.482,"rank":13635,"name":"Wbp4","annotation":"WW domain-binding protein 4; Involved in pre-mRNA splicing as a component of the spliceosome. May play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex."},{"id":"ENSMUSP00000060309","abundance":0.481,"rank":13636,"name":"Ccdc89","annotation":"Coiled-coil domain-containing protein 89; Belongs to the CCDC89 family."},{"id":"ENSMUSP00000070018","abundance":0.481,"rank":13637,"name":"Cthrc1","annotation":"Collagen triple helix repeat-containing protein 1; May act as a negative regulator of collagen matrix deposition."},{"id":"ENSMUSP00000077761","abundance":0.481,"rank":13638,"name":"Gm13078","annotation":"Predicted gene 13078."},{"id":"ENSMUSP00000057346","abundance":0.481,"rank":13639,"name":"Dusp18","annotation":"Dual specificity protein phosphatase 18; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP)."},{"id":"ENSMUSP00000049705","abundance":0.481,"rank":13640,"name":"Rexo1","annotation":"RNA exonuclease 1 homolog; Seems to have no detectable effect on transcription elongation in vitro."},{"id":"ENSMUSP00000128907","abundance":0.48,"rank":13641,"name":"Gm5798","annotation":"Predicted gene 5798."},{"id":"ENSMUSP00000098522","abundance":0.48,"rank":13642,"name":"Gbp4","annotation":"Guanylate binding protein 4.1."},{"id":"ENSMUSP00000018877","abundance":0.48,"rank":13643,"name":"Pex12","annotation":"Peroxisome assembly protein 12; Required for protein import into peroxisomes."},{"id":"ENSMUSP00000003434","abundance":0.48,"rank":13644,"name":"Btbd2","annotation":"BTB (POZ) domain-containing 2."},{"id":"ENSMUSP00000080399","abundance":0.48,"rank":13645,"name":"Olfr1193","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000142518","abundance":0.479,"rank":13646,"name":"Gbp6","annotation":"Guanylate-binding protein 6."},{"id":"ENSMUSP00000062528","abundance":0.479,"rank":13647,"name":"Gm43302","annotation":"Predicted gene 43302."},{"id":"ENSMUSP00000152585","abundance":0.479,"rank":13648,"name":"Gm42517","annotation":"Predicted gene 42517."},{"id":"ENSMUSP00000019927","abundance":0.479,"rank":13649,"name":"Trmt11","annotation":"tRNA (guanine(10)-N2)-methyltransferase homolog; Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family."},{"id":"ENSMUSP00000065157","abundance":0.479,"rank":13650,"name":"Npy5r","annotation":"Neuropeptide Y receptor type 5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders (By similarity); Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000123201","abundance":0.479,"rank":13651,"name":"Bicc1","annotation":"Protein bicaudal C homolog 1; Putative RNA-binding protein. May be involved in regulating gene expression during embryonic development; Belongs to the BicC family."},{"id":"ENSMUSP00000148984","abundance":0.479,"rank":13652,"name":"Olfr732","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000011400","abundance":0.478,"rank":13653,"name":"Adam19","annotation":"Disintegrin and metalloproteinase domain-containing protein 19; Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity)."},{"id":"ENSMUSP00000003154","abundance":0.478,"rank":13654,"name":"Efna2","annotation":"Ephrin-A2; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling thro [...] "},{"id":"ENSMUSP00000030269","abundance":0.478,"rank":13655,"name":"Slc6a9","annotation":"Sodium- and chloride-dependent glycine transporter 1; Terminates the action of glycine by its high affinity sodium- dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily."},{"id":"ENSMUSP00000118997","abundance":0.478,"rank":13656,"name":"Cbfa2t3","annotation":"Protein CBFA2T3; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulatin [...] "},{"id":"ENSMUSP00000022518","abundance":0.478,"rank":13657,"name":"Eef1akmt1","annotation":"EEF1A lysine methyltransferase 1; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family."},{"id":"ENSMUSP00000006679","abundance":0.478,"rank":13658,"name":"Prtn3","annotation":"Myeloblastin; Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177; Belongs to the peptidase S1 family. Elastase subfamily."},{"id":"ENSMUSP00000097961","abundance":0.478,"rank":13659,"name":"BC030867","annotation":"Uncharacterized protein C17orf53 homolog."},{"id":"ENSMUSP00000038056","abundance":0.477,"rank":13660,"name":"P3h2","annotation":"Prolyl 3-hydroxylase 2; Prolyl 3-hydroxylase that catalyzes the post-translational formation of 3-hydroxyproline on collagens. Contributes to proline 3-hydroxylation of collagen COL4A1 and COL1A1 in tendons, the eye sclera and in the eye lens capsule. Has high activity with the type IV collagen COL4A1, and lower activity with COL1A1. Catalyzes hydroxylation of the first Pro in Gly-Pro-Hyp sequences where Hyp is 4-hydroxyproline. Has no activity on substrates that have proline instead of 4-hydroxyproline in the third position (By similarity)."},{"id":"ENSMUSP00000076562","abundance":0.477,"rank":13661,"name":"Irx1","annotation":"Iroquois-class homeodomain protein IRX-1."},{"id":"ENSMUSP00000063450","abundance":0.477,"rank":13662,"name":"Cfap300","annotation":"Cilia- and flagella-associated protein 300; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly; Belongs to the CFAP300 family."},{"id":"ENSMUSP00000054771","abundance":0.477,"rank":13663,"name":"Ccdc169","annotation":"Coiled-coil domain-containing protein 169."},{"id":"ENSMUSP00000108321","abundance":0.477,"rank":13664,"name":"Cdh7","annotation":"Cadherin-7; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)."},{"id":"ENSMUSP00000022036","abundance":0.477,"rank":13665,"name":"Slc28a3","annotation":"Solute carrier family 28 member 3; Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'- azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (By similarity); Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family."},{"id":"ENSMUSP00000040062","abundance":0.477,"rank":13666,"name":"Ica1","annotation":"Islet cell autoantigen 1; May play a role in neurotransmitter secretion."},{"id":"ENSMUSP00000041597","abundance":0.476,"rank":13667,"name":"Gm9758","annotation":"Predicted gene, ENSMUSG00000033219."},{"id":"ENSMUSP00000010044","abundance":0.476,"rank":13668,"name":"Wnt3a","annotation":"Protein Wnt-3a; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro)."},{"id":"ENSMUSP00000091488","abundance":0.476,"rank":13669,"name":"Hsf5","annotation":"Heat shock factor protein 5; May act as a transcriptional factor."},{"id":"ENSMUSP00000137333","abundance":0.476,"rank":13670,"name":"Dapk3","annotation":"Death-associated protein kinase 3; Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation; in vitro phosphorylates PAWR (By similarity). Phosphorylates MYL12B in non-muscle cells leading to  [...] "},{"id":"ENSMUSP00000053232","abundance":0.476,"rank":13671,"name":"Stard13","annotation":"StAR-related lipid transfer protein 13; May function as a GTPase-activating protein."},{"id":"ENSMUSP00000125803","abundance":0.476,"rank":13672,"name":"Loxl4","annotation":"Lysyl oxidase homolog 4; May modulate the formation of a collagenous extracellular matrix."},{"id":"ENSMUSP00000072063","abundance":0.475,"rank":13673,"name":"Klk1b8","annotation":"Kallikrein 1-related peptidase b8; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin; Belongs to the peptidase S1 family. Kallikrein subfamily."},{"id":"ENSMUSP00000048816","abundance":0.475,"rank":13674,"name":"Zmynd15","annotation":"Zinc finger MYND domain-containing protein 15; Acts as a transcriptional repressor through interaction with histone deacetylases (HDACs). May regulate haploid genes important for spermiogenesis."},{"id":"ENSMUSP00000157469","abundance":0.475,"rank":13675,"name":"Dnah8","annotation":"Dynein heavy chain 8, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly."},{"id":"ENSMUSP00000137597","abundance":0.475,"rank":13676,"name":"Ccdc191","annotation":"Coiled-coil domain-containing 191."},{"id":"ENSMUSP00000066690","abundance":0.475,"rank":13677,"name":"Nkx2-4","annotation":"Homeobox protein Nkx-2.4; Probable transcription factor; Belongs to the NK-2 homeobox family."},{"id":"ENSMUSP00000029730","abundance":0.475,"rank":13678,"name":"Chd1l","annotation":"Chromodomain-helicase-DNA-binding protein 1-like; DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP- dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding (By similarity); Belongs to the SNF2/RAD54 helicase family."},{"id":"ENSMUSP00000085728","abundance":0.475,"rank":13679,"name":"Slc15a1","annotation":"Solute carrier family 15 member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products (By similarity). Belongs to the PTR2/POT transporter (TC 2.A.17) family."},{"id":"ENSMUSP00000034351","abundance":0.475,"rank":13680,"name":"Rrad","annotation":"GTP-binding protein RAD; May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D; Belongs to the small GTPase superfamily. RGK family."},{"id":"ENSMUSP00000058233","abundance":0.475,"rank":13681,"name":"Fbxo10","annotation":"F-box only protein 10; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2."},{"id":"ENSMUSP00000022450","abundance":0.475,"rank":13682,"name":"Tasor","annotation":"Protein TASOR; Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2. Also represses L1 retrotransposons in collaboration with MORC2 and, probably, SETDB1, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally act [...] "},{"id":"ENSMUSP00000027178","abundance":0.475,"rank":13683,"name":"Als2","annotation":"Alsin; May act as a GTPase regulator. Controls survival and growth of spinal motoneurons."},{"id":"ENSMUSP00000024993","abundance":0.475,"rank":13684,"name":"Prss29","annotation":"Serine protease 29; Involved in embryo hatching and implantation. Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000033979","abundance":0.475,"rank":13685,"name":"Star","annotation":"Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Transporter that binds to and transport cholesterol through the intermembrane space of the mitochondrion."},{"id":"ENSMUSP00000040808","abundance":0.475,"rank":13686,"name":"Chrm4","annotation":"Muscarinic acetylcholine receptor M4; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily."},{"id":"ENSMUSP00000128769","abundance":0.475,"rank":13687,"name":"Gm8011","annotation":"Predicted gene 8011."},{"id":"ENSMUSP00000089157","abundance":0.475,"rank":13688,"name":"4930486L24Rik","annotation":"Testin-1; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000041614","abundance":0.475,"rank":13689,"name":"Akna","annotation":"Microtubule organization protein AKNA; Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization. Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis. Also regulates the epithelial-to-mesenchymal transition in other epithelial cells. Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot. In addition, may also act  [...] "},{"id":"ENSMUSP00000002914","abundance":0.474,"rank":13690,"name":"Chaf1a","annotation":"Chromatin assembly factor 1 subunit A; Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly [...] "},{"id":"ENSMUSP00000098987","abundance":0.474,"rank":13691,"name":"Kcnk3","annotation":"Potassium channel subfamily K member 3; pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward."},{"id":"ENSMUSP00000071623","abundance":0.474,"rank":13692,"name":"Tut7","annotation":"Terminal uridylyltransferase 7; Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay. Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth. Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of miRNA precursors, incl [...] "},{"id":"ENSMUSP00000066427","abundance":0.474,"rank":13693,"name":"Cldn17","annotation":"Claudin-17; Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability; Belongs to the claudin family."},{"id":"ENSMUSP00000016781","abundance":0.474,"rank":13694,"name":"Ift27","annotation":"Intraflagellar transport protein 27 homolog; Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6. Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25 (By similarity). Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella format [...] "},{"id":"ENSMUSP00000061229","abundance":0.474,"rank":13695,"name":"Mettl21c","annotation":"Protein-lysine methyltransferase METTL21C; Protein-lysine methyltransferase."},{"id":"ENSMUSP00000086731","abundance":0.474,"rank":13696,"name":"Gpr15","annotation":"G-protein coupled receptor 15; Probable chemokine receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000069444","abundance":0.474,"rank":13697,"name":"Glcci1","annotation":"Glucocorticoid-induced transcript 1 protein."},{"id":"ENSMUSP00000043439","abundance":0.474,"rank":13698,"name":"Klhdc4","annotation":"Kelch domain-containing protein 4."},{"id":"ENSMUSP00000061095","abundance":0.473,"rank":13699,"name":"Kdm5d","annotation":"Lysine-specific demethylase 5D; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity  [...] "},{"id":"ENSMUSP00000064897","abundance":0.473,"rank":13700,"name":"Chst13","annotation":"Carbohydrate sulfotransferase."},{"id":"ENSMUSP00000004920","abundance":0.473,"rank":13701,"name":"Ulk2","annotation":"Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1 [...] "},{"id":"ENSMUSP00000124089","abundance":0.472,"rank":13702,"name":"Zfp609","annotation":"Zinc finger protein 609; Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others."},{"id":"ENSMUSP00000019994","abundance":0.472,"rank":13703,"name":"Popdc3","annotation":"Popeye domain-containing protein 3; May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding."},{"id":"ENSMUSP00000156344","abundance":0.472,"rank":13704,"name":"Atm","annotation":"Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] "},{"id":"ENSMUSP00000040952","abundance":0.472,"rank":13705,"name":"Rbm48","annotation":"RNA-binding protein 48."},{"id":"ENSMUSP00000091895","abundance":0.472,"rank":13706,"name":"Fcrlb","annotation":"Fc receptor-like B."},{"id":"ENSMUSP00000001402","abundance":0.472,"rank":13707,"name":"Fbxo9","annotation":"F-box only protein 9; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTOR [...] "},{"id":"ENSMUSP00000034245","abundance":0.472,"rank":13708,"name":"Usb1","annotation":"U6 snRNA phosphodiesterase; Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate; Belongs to the 2H phosphoesterase superfamily. USB1 family."},{"id":"ENSMUSP00000126909","abundance":0.471,"rank":13709,"name":"Taf4b","annotation":"Transcription initiation factor TFIID subunit 4B; Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators asond repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in sp [...] "},{"id":"ENSMUSP00000132956","abundance":0.471,"rank":13710,"name":"Gm7995","annotation":"Predicted gene 7995."},{"id":"ENSMUSP00000127886","abundance":0.471,"rank":13711,"name":"Gm10378","annotation":"Predicted gene 10378."},{"id":"ENSMUSP00000002099","abundance":0.471,"rank":13712,"name":"Ift46","annotation":"Intraflagellar transport protein 46 homolog; Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis."},{"id":"ENSMUSP00000151777","abundance":0.471,"rank":13713,"name":"Olfr1555-ps1","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000027569","abundance":0.471,"rank":13714,"name":"Slco6c1","annotation":"Solute carrier organic anion transporter family, member 6c1."},{"id":"ENSMUSP00000097496","abundance":0.471,"rank":13715,"name":"Olfr1024","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000059091","abundance":0.471,"rank":13716,"name":"Fkrp","annotation":"Fukutin-related protein; Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (phosphate-6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1) (By similarity). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta- 1 (By similarity)."},{"id":"ENSMUSP00000126313","abundance":0.471,"rank":13717,"name":"Rfx3","annotation":"Transcription factor RFX3; Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypept [...] "},{"id":"ENSMUSP00000038719","abundance":0.47,"rank":13718,"name":"Trim14","annotation":"Tripartite motif-containing protein 14; Plays a role in the innate immune defense against viruses. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner ; Bel [...] "},{"id":"ENSMUSP00000091532","abundance":0.47,"rank":13719,"name":"Sez6","annotation":"Seizure protein 6; May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity."},{"id":"ENSMUSP00000086462","abundance":0.47,"rank":13720,"name":"Rhox9","annotation":"Reproductive homeobox on X chromosome 9."},{"id":"ENSMUSP00000098765","abundance":0.47,"rank":13721,"name":"Col4a6","annotation":"Collagen, type IV, alpha 6."},{"id":"ENSMUSP00000150619","abundance":0.47,"rank":13722,"name":"Olfr987","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000157197","abundance":0.47,"rank":13723,"name":"Armc4","annotation":"Armadillo repeat-containing protein 4; Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly."},{"id":"ENSMUSP00000030313","abundance":0.47,"rank":13724,"name":"Caap1","annotation":"Caspase activity and apoptosis inhibitor 1; Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop."},{"id":"ENSMUSP00000034988","abundance":0.47,"rank":13725,"name":"Rwdd2a","annotation":"RWD domain-containing protein 2A."},{"id":"ENSMUSP00000126008","abundance":0.47,"rank":13726,"name":"Cst12","annotation":"Cystatin-12; May play a specialized role in spermatogenesis."},{"id":"ENSMUSP00000124258","abundance":0.469,"rank":13727,"name":"Parp4","annotation":"Protein mono-ADP-ribosyltransferase PARP4; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins."},{"id":"ENSMUSP00000015889","abundance":0.469,"rank":13728,"name":"Plekho1","annotation":"Pleckstrin homology domain-containing family O member 1; Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocat [...] "},{"id":"ENSMUSP00000036394","abundance":0.469,"rank":13729,"name":"Pyroxd1","annotation":"Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity (By similarity)."},{"id":"ENSMUSP00000001202","abundance":0.469,"rank":13730,"name":"Ocrl","annotation":"Inositol polyphosphate 5-phosphatase OCRL; Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5- bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a reg [...] "},{"id":"ENSMUSP00000071348","abundance":0.469,"rank":13731,"name":"Psg16","annotation":"Pregnancy-specific glycoprotein 16."},{"id":"ENSMUSP00000044044","abundance":0.469,"rank":13732,"name":"Padi6","annotation":"Protein-arginine deiminase type-6; Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo."},{"id":"ENSMUSP00000040045","abundance":0.468,"rank":13733,"name":"Ranbp10","annotation":"Ran-binding protein 10; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1 (By similarity). Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide [...] "},{"id":"ENSMUSP00000145255","abundance":0.468,"rank":13734,"name":"Gimap8","annotation":"GTPase IMAP family member 8; Exerts an anti-apoptotic effect in the immune system and is involved in responses to infections."},{"id":"ENSMUSP00000031837","abundance":0.468,"rank":13735,"name":"Doxl1","annotation":"Amine oxidase."},{"id":"ENSMUSP00000045023","abundance":0.468,"rank":13736,"name":"Slco4a1","annotation":"Solute carrier organic anion transporter family member 4A1; Mediates the Na(+)-independent transport of organic anions such as the thyroid hormone T3 (triiodo-L-thyronine) and of taurocholate."},{"id":"ENSMUSP00000020255","abundance":0.468,"rank":13737,"name":"Slc5a8","annotation":"Sodium-coupled monocarboxylate transporter 1; Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)- dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D- lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5- aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. M [...] "},{"id":"ENSMUSP00000029711","abundance":0.468,"rank":13738,"name":"Insrr","annotation":"Insulin receptor-related protein alpha chain; Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB."},{"id":"ENSMUSP00000094042","abundance":0.468,"rank":13739,"name":"Ap5b1","annotation":"AP-5 complex subunit beta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport."},{"id":"ENSMUSP00000051433","abundance":0.467,"rank":13740,"name":"Pthlh","annotation":"Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity o [...] "},{"id":"ENSMUSP00000091245","abundance":0.467,"rank":13741,"name":"Fam149a","annotation":"Protein FAM149A; Belongs to the FAM149 family."},{"id":"ENSMUSP00000027066","abundance":0.467,"rank":13742,"name":"Eya1","annotation":"Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulat [...] "},{"id":"ENSMUSP00000034981","abundance":0.467,"rank":13743,"name":"Xrn1","annotation":"5'-3' exoribonuclease 1; Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA. Plays a role in replication-dependent histone mRNA degradation (By similarity)."},{"id":"ENSMUSP00000140828","abundance":0.466,"rank":13744,"name":"Tmem163","annotation":"Transmembrane protein 163; May bind zinc and other divalent cations and recruit them to vesicular organelles."},{"id":"ENSMUSP00000114717","abundance":0.466,"rank":13745,"name":"Urb1","annotation":"Nucleolar pre-ribosomal-associated protein 1."},{"id":"ENSMUSP00000115957","abundance":0.466,"rank":13746,"name":"Rtl1","annotation":"Retrotransposon-like protein 1; Plays an essential role in capillaries endothelial cells for the maintenance of feto-maternal interface and for development of the placenta."},{"id":"ENSMUSP00000136362","abundance":0.466,"rank":13747,"name":"Gm6367","annotation":"Predicted gene 6367."},{"id":"ENSMUSP00000025872","abundance":0.465,"rank":13748,"name":"4430402I18Rik","annotation":"Spermatogenesis associated 6-like protein; Belongs to the SPATA6 family."},{"id":"ENSMUSP00000067539","abundance":0.465,"rank":13749,"name":"Ostn","annotation":"Processed Osteocrin; Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C. May act as an autocrine and paracrine factor linked [...] "},{"id":"ENSMUSP00000112620","abundance":0.465,"rank":13750,"name":"Usf3","annotation":"Upstream transcription factor family member 3."},{"id":"ENSMUSP00000052294","abundance":0.465,"rank":13751,"name":"Ccdc121","annotation":"Coiled-coil domain-containing 121."},{"id":"ENSMUSP00000078560","abundance":0.465,"rank":13752,"name":"Frg2f1","annotation":"FSHD region gene 2 family member 1."},{"id":"ENSMUSP00000147673","abundance":0.465,"rank":13753,"name":"Zfp143","annotation":"Zinc finger protein 143; Transcriptional activator. Activates the gene for selenocysteine tRNA (tRNAsec). Binds to the SPH motif of small nuclear RNA (snRNA) gene promoters. Participates in efficient U6 RNA polymerase III transcription via its interaction with CHD8 (By similarity)."},{"id":"ENSMUSP00000029346","abundance":0.464,"rank":13754,"name":"Schip1","annotation":"Schwannomin-interacting protein 1; Belongs to the SCHIP1 family."},{"id":"ENSMUSP00000060017","abundance":0.464,"rank":13755,"name":"Tmem74b","annotation":"Transmembrane protein 74B."},{"id":"ENSMUSP00000104730","abundance":0.464,"rank":13756,"name":"Cdyl2","annotation":"Chromodomain Y-like protein 2."},{"id":"ENSMUSP00000025311","abundance":0.464,"rank":13757,"name":"Pcdh12","annotation":"Protocadherin-12, secreted form; Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Acts as a regulator of cell migration, probably via increasing cell- cell adhesion (By similarity). Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton."},{"id":"ENSMUSP00000028471","abundance":0.464,"rank":13758,"name":"Smtnl1","annotation":"Smoothelin-like protein 1; Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity."},{"id":"ENSMUSP00000058596","abundance":0.464,"rank":13759,"name":"Mlf1","annotation":"Myeloid leukemia factor 1; Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus."},{"id":"ENSMUSP00000071970","abundance":0.464,"rank":13760,"name":"Hsh2d","annotation":"Hematopoietic SH2 domain-containing protein; Adapter protein involved in tyrosine kinase and CD28 signaling (By similarity). May be a modulator of the apoptotic response through its ability to affect mitochondrial stability."},{"id":"ENSMUSP00000065225","abundance":0.464,"rank":13761,"name":"March2","annotation":"E3 ubiquitin-protein ligase MARCHF2; E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6."},{"id":"ENSMUSP00000065146","abundance":0.464,"rank":13762,"name":"Lrguk","annotation":"Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis."},{"id":"ENSMUSP00000036582","abundance":0.463,"rank":13763,"name":"Zfp532","annotation":"Zinc finger protein 532; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000110877","abundance":0.463,"rank":13764,"name":"Zbtb44","annotation":"Zinc finger and BTB domain-containing protein 44."},{"id":"ENSMUSP00000096400","abundance":0.463,"rank":13765,"name":"Obox5","annotation":"Oocyte-specific homeobox 5."},{"id":"ENSMUSP00000076364","abundance":0.463,"rank":13766,"name":"Ptpro","annotation":"Receptor-type tyrosine-protein phosphatase O; Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily."},{"id":"ENSMUSP00000111398","abundance":0.463,"rank":13767,"name":"Gucy1a2","annotation":"Guanylate cyclase 1, soluble, alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family."},{"id":"ENSMUSP00000031009","abundance":0.463,"rank":13768,"name":"Nsg1","annotation":"Neuronal vesicle trafficking-associated protein 1; Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse. Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early end [...] "},{"id":"ENSMUSP00000029910","abundance":0.462,"rank":13769,"name":"Nsmaf","annotation":"Protein FAN; Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N-smase activation domain of TNF-R55. May regulate ceramide production by N- SMASE."},{"id":"ENSMUSP00000037121","abundance":0.462,"rank":13770,"name":"Zup1","annotation":"Zinc finger-containing ubiquitin peptidase 1; Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains. Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage. Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress."},{"id":"ENSMUSP00000082476","abundance":0.462,"rank":13771,"name":"Slc6a21","annotation":"Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family."},{"id":"ENSMUSP00000105248","abundance":0.462,"rank":13772,"name":"Cep250","annotation":"Centrosome-associated protein CEP250; May be involved in ciliogenesis. Probably plays an important role in centrosome cohesion during interphase."},{"id":"ENSMUSP00000058175","abundance":0.461,"rank":13773,"name":"Fbxw15","annotation":"F-box/WD repeat-containing protein 15; Substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes KAT7 ubiquitination and subsequent degradation in collaboration with MAP2K1 kinase, leading to reduced histone H3K14 acetylation and increased cell proliferation."},{"id":"ENSMUSP00000035437","abundance":0.461,"rank":13774,"name":"Zbed4","annotation":"Zinc finger BED domain-containing protein 4."},{"id":"ENSMUSP00000112778","abundance":0.461,"rank":13775,"name":"Zbtb9","annotation":"Zinc finger and BTB domain-containing protein 9; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000029196","abundance":0.461,"rank":13776,"name":"Slc2a10","annotation":"Solute carrier family 2, facilitated glucose transporter member 10; Facilitative glucose transporter required for the development of the cardiovascular system."},{"id":"ENSMUSP00000128652","abundance":0.461,"rank":13777,"name":"Fbxw25","annotation":"F-box and WD-40 domain protein 25."},{"id":"ENSMUSP00000049206","abundance":0.461,"rank":13778,"name":"Kcnh8","annotation":"Potassium voltage-gated channel subfamily H member 8; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly (By similarity); Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv12.1/KCNH8 sub-subfamily."},{"id":"ENSMUSP00000026568","abundance":0.461,"rank":13779,"name":"Ptdss2","annotation":"Phosphatidylserine synthase 2; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine; Belongs to the phosphatidyl serine synthase family."},{"id":"ENSMUSP00000101425","abundance":0.461,"rank":13780,"name":"Arhgef10l","annotation":"Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC."},{"id":"ENSMUSP00000014927","abundance":0.461,"rank":13781,"name":"Plekhg4","annotation":"Pleckstrin homology domain-containing, family G (with RhoGef domain) member 4."},{"id":"ENSMUSP00000036320","abundance":0.461,"rank":13782,"name":"Trhr","annotation":"Thyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. Activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000098108","abundance":0.46,"rank":13783,"name":"Tsc22d4","annotation":"TSC22 domain family protein 4; Transcriptional repressor; Belongs to the TSC-22/Dip/Bun family."},{"id":"ENSMUSP00000115136","abundance":0.46,"rank":13784,"name":"Frmd5","annotation":"FERM domain-containing protein 5; May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation."},{"id":"ENSMUSP00000045667","abundance":0.46,"rank":13785,"name":"Fancd2","annotation":"Fanconi anemia group D2 protein homolog; Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-ce [...] "},{"id":"ENSMUSP00000139717","abundance":0.46,"rank":13786,"name":"Cyp4a29","annotation":"Cytochrome P450, family 4, subfamily a, polypeptide 29; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000115498","abundance":0.46,"rank":13787,"name":"Gm28042","annotation":"Phospholipase A2."},{"id":"ENSMUSP00000048524","abundance":0.46,"rank":13788,"name":"Sox15","annotation":"Protein SOX-15; Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence. Acts as a transcriptional activator and repressor. Binds synergistically with POU5F1 (OCT3/4) to gene promoters. Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation. Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG. Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional a [...] "},{"id":"ENSMUSP00000017891","abundance":0.46,"rank":13789,"name":"Ghdc","annotation":"GH3 domain-containing protein; Belongs to the GH3 family."},{"id":"ENSMUSP00000049026","abundance":0.46,"rank":13790,"name":"Fnip1","annotation":"Folliculin-interacting protein 1; Acts as a co-chaperone of HSP90AA1. Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. Facilitates the binding of client protein FLCN to HSP90AA1. Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1."},{"id":"ENSMUSP00000049497","abundance":0.46,"rank":13791,"name":"Ccdc113","annotation":"Coiled-coil domain-containing protein 113; Component of centriolar satellites contributing to primary cilium formation."},{"id":"ENSMUSP00000032200","abundance":0.46,"rank":13792,"name":"Slc6a12","annotation":"Sodium- and chloride-dependent betaine transporter; Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (By similarity); Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily."},{"id":"ENSMUSP00000040248","abundance":0.46,"rank":13793,"name":"Zkscan8","annotation":"Zinc finger with KRAB and SCAN domains 8."},{"id":"ENSMUSP00000044926","abundance":0.459,"rank":13794,"name":"Tmem35a","annotation":"Transmembrane protein 35A; A soluble peptide released by shedding may interact with NGFR and modulate neurite outgrowth."},{"id":"ENSMUSP00000125325","abundance":0.459,"rank":13795,"name":"Zfp949","annotation":"Zinc finger protein 949."},{"id":"ENSMUSP00000096670","abundance":0.459,"rank":13796,"name":"Mocs3","annotation":"Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] "},{"id":"ENSMUSP00000156991","abundance":0.459,"rank":13797,"name":"Gm5155","annotation":"Predicted gene 5155."},{"id":"ENSMUSP00000058858","abundance":0.458,"rank":13798,"name":"Adam34l","annotation":"A disintegrin and metallopeptidase domain 34-like."},{"id":"ENSMUSP00000046598","abundance":0.458,"rank":13799,"name":"Senp1","annotation":"Sentrin-specific protease 1; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. Deconjugates SUMO1 from HIPK2 (By similarity). Deconjug [...] "},{"id":"ENSMUSP00000127504","abundance":0.458,"rank":13800,"name":"L1td1","annotation":"LINE-1 type transposase domain-containing protein 1; Belongs to the transposase 22 family."},{"id":"ENSMUSP00000098840","abundance":0.458,"rank":13801,"name":"Cylc1","annotation":"Cylicin, basic protein of sperm head cytoskeleton 1."},{"id":"ENSMUSP00000105904","abundance":0.458,"rank":13802,"name":"Serpinb6e","annotation":"Serine (or cysteine) peptidase inhibitor, clade B, member 6e; Belongs to the serpin family."},{"id":"ENSMUSP00000063554","abundance":0.457,"rank":13803,"name":"Gemin6","annotation":"Gem-associated protein 6; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...] "},{"id":"ENSMUSP00000126103","abundance":0.457,"rank":13804,"name":"Chrm1","annotation":"Muscarinic acetylcholine receptor M1; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover."},{"id":"ENSMUSP00000031587","abundance":0.457,"rank":13805,"name":"Ung","annotation":"Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine."},{"id":"ENSMUSP00000034004","abundance":0.457,"rank":13806,"name":"Pdgfrl","annotation":"Platelet-derived growth factor receptor-like protein."},{"id":"ENSMUSP00000022007","abundance":0.457,"rank":13807,"name":"1700001L19Rik","annotation":"Uncharacterized protein C5orf49 homolog."},{"id":"ENSMUSP00000151883","abundance":0.457,"rank":13808,"name":"Olfr518","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000099135","abundance":0.456,"rank":13809,"name":"Kcp","annotation":"Kielin/chordin-like protein; Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways."},{"id":"ENSMUSP00000000010","abundance":0.456,"rank":13810,"name":"Hoxb9","annotation":"Homeobox protein Hox-B9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family."},{"id":"ENSMUSP00000042958","abundance":0.456,"rank":13811,"name":"Tlcd2","annotation":"TLC domain-containing protein 2; Regulates the composition and fluidity of the plasma membrane (By similarity). Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity (By similarity). Does not appear to have any effect on LCPUFA synthesis (By similarity)."},{"id":"ENSMUSP00000021004","abundance":0.456,"rank":13812,"name":"Sntg2","annotation":"Gamma-2-syntrophin; Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity)."},{"id":"ENSMUSP00000127981","abundance":0.456,"rank":13813,"name":"Vmn2r113","annotation":"Vomeronasal 2, receptor 113."},{"id":"ENSMUSP00000039900","abundance":0.456,"rank":13814,"name":"Arhgef11","annotation":"Rho guanine nucleotide exchange factor (GEF) 11."},{"id":"ENSMUSP00000033173","abundance":0.456,"rank":13815,"name":"Polr3e","annotation":"DNA-directed RNA polymerase III subunit RPC5; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific periphjeric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA t [...] "},{"id":"ENSMUSP00000138377","abundance":0.455,"rank":13816,"name":"Kat6b","annotation":"Histone acetyltransferase KAT6B; Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2- dependent transcriptional activation. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity). Involved in cerebral cortex development; Belongs to the MYST (SAS/MOZ) family."},{"id":"ENSMUSP00000056739","abundance":0.455,"rank":13817,"name":"Gpr107","annotation":"Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity)."},{"id":"ENSMUSP00000044879","abundance":0.455,"rank":13818,"name":"Isl1","annotation":"Insulin gene enhancer protein ISL-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences (By similarity [...] "},{"id":"ENSMUSP00000141197","abundance":0.455,"rank":13819,"name":"Elf2","annotation":"ETS-related transcription factor Elf-2; Probably transcriptionally activates the LYN and BLK promoters and acts synergistically with RUNX1 to transactivate the BLK promoter."},{"id":"ENSMUSP00000048736","abundance":0.455,"rank":13820,"name":"Ptger4","annotation":"Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function."},{"id":"ENSMUSP00000085900","abundance":0.454,"rank":13821,"name":"Xkr9","annotation":"XK-related protein 9."},{"id":"ENSMUSP00000041411","abundance":0.454,"rank":13822,"name":"Rhov","annotation":"Rho-related GTP-binding protein RhoV; Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway; Belongs to the small GTPase superfamily. Rho family."},{"id":"ENSMUSP00000107701","abundance":0.454,"rank":13823,"name":"Col7a1","annotation":"Collagen alpha-1(VII) chain; Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen."},{"id":"ENSMUSP00000033549","abundance":0.454,"rank":13824,"name":"Asb12","annotation":"Ankyrin repeat and SOCS box protein 12; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family."},{"id":"ENSMUSP00000022728","abundance":0.454,"rank":13825,"name":"Gpr180","annotation":"Integral membrane protein GPR180."},{"id":"ENSMUSP00000152536","abundance":0.454,"rank":13826,"name":"Nol8","annotation":"Nucleolar protein 8; Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post- transcriptional level or in ribosome biogenesis in cancer cells (By similarity)."},{"id":"ENSMUSP00000143291","abundance":0.454,"rank":13827,"name":"Atg4a-ps","annotation":"Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family."},{"id":"ENSMUSP00000108595","abundance":0.454,"rank":13828,"name":"Atg4a","annotation":"Cysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity)."},{"id":"ENSMUSP00000054343","abundance":0.454,"rank":13829,"name":"Gjb2","annotation":"Gap junction beta-2 protein; Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore."},{"id":"ENSMUSP00000021596","abundance":0.454,"rank":13830,"name":"Nrde2","annotation":"Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, [...] "},{"id":"ENSMUSP00000059587","abundance":0.454,"rank":13831,"name":"Gja3","annotation":"Gap junction alpha-3 protein; Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore."},{"id":"ENSMUSP00000128052","abundance":0.453,"rank":13832,"name":"Gfi1b","annotation":"Zinc finger protein Gfi-1b; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA [...] "},{"id":"ENSMUSP00000091495","abundance":0.453,"rank":13833,"name":"Ccnd1","annotation":"G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] "},{"id":"ENSMUSP00000076206","abundance":0.453,"rank":13834,"name":"C1qtnf7","annotation":"Complement C1q tumor necrosis factor-related protein 7."},{"id":"ENSMUSP00000058535","abundance":0.453,"rank":13835,"name":"Serpina9","annotation":"Serpin A9."},{"id":"ENSMUSP00000033341","abundance":0.453,"rank":13836,"name":"Tub","annotation":"Tubby protein; Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight. Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages (By similarity)."},{"id":"ENSMUSP00000060441","abundance":0.453,"rank":13837,"name":"Dmrta2","annotation":"Doublesex- and mab-3-related transcription factor A2; May be involved in sexual development; Belongs to the DMRT family."},{"id":"ENSMUSP00000040271","abundance":0.453,"rank":13838,"name":"Tnfsf10","annotation":"Tumor necrosis factor ligand superfamily member 10; Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis."},{"id":"ENSMUSP00000069024","abundance":0.453,"rank":13839,"name":"Sema5a","annotation":"Semaphorin-5A; Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 (By similarity). May promote angiogenesis [...] "},{"id":"ENSMUSP00000072064","abundance":0.452,"rank":13840,"name":"Poc1a","annotation":"POC1 centriolar protein homolog A; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation (By similarity)."},{"id":"ENSMUSP00000131454","abundance":0.452,"rank":13841,"name":"Supt20","annotation":"Transcription factor SPT20 homolog; Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by FGF signaling and Snail. Required for starvation-induced ATG9A trafficking during autophagy."},{"id":"ENSMUSP00000019183","abundance":0.452,"rank":13842,"name":"Dalrd3","annotation":"DALR anticodon-binding domain-containing protein 3."},{"id":"ENSMUSP00000044815","abundance":0.452,"rank":13843,"name":"Suco","annotation":"SUN domain-containing ossification factor; Required for bone modeling during late embryogenesis. Regulates type I collagen synthesis in osteoblasts during their postnatal maturation."},{"id":"ENSMUSP00000018821","abundance":0.452,"rank":13844,"name":"Slc25a39","annotation":"Solute carrier family 25 member 39; Required for normal heme biosynthesis; Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000097784","abundance":0.452,"rank":13845,"name":"4930562C15Rik","annotation":"Uncharacterized protein C16orf96 homolog."},{"id":"ENSMUSP00000077919","abundance":0.451,"rank":13846,"name":"Sorcs3","annotation":"VPS10 domain-containing receptor SorCS3."},{"id":"ENSMUSP00000066493","abundance":0.451,"rank":13847,"name":"Mrpl35","annotation":"39S ribosomal protein L35, mitochondrial."},{"id":"ENSMUSP00000006559","abundance":0.45,"rank":13848,"name":"Tpbg","annotation":"Trophoblast glycoprotein; May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization."},{"id":"ENSMUSP00000109592","abundance":0.45,"rank":13849,"name":"Dcaf8l","annotation":"DDB1 and CUL4-associated factor 8-like."},{"id":"ENSMUSP00000031902","abundance":0.45,"rank":13850,"name":"Trpv6","annotation":"Transient receptor potential cation channel subfamily V member 6; Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both a rapid Ca(2+)- dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly i [...] "},{"id":"ENSMUSP00000123588","abundance":0.45,"rank":13851,"name":"Brwd3","annotation":"Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity)."},{"id":"ENSMUSP00000131220","abundance":0.45,"rank":13852,"name":"Vmn2r7","annotation":"Vomeronasal 2, receptor 7."},{"id":"ENSMUSP00000025089","abundance":0.45,"rank":13853,"name":"Map4k3","annotation":"Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity). Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily."},{"id":"ENSMUSP00000138389","abundance":0.45,"rank":13854,"name":"Olfr67","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000122903","abundance":0.45,"rank":13855,"name":"Ppp1r3f","annotation":"Protein phosphatase 1 regulatory subunit 3F; Glycogen-targeting subunit for protein phosphatase 1 (PP1)."},{"id":"ENSMUSP00000096407","abundance":0.449,"rank":13856,"name":"Sult2a3","annotation":"Sulfotransferase; Belongs to the sulfotransferase 1 family."},{"id":"ENSMUSP00000016323","abundance":0.449,"rank":13857,"name":"Camk1g","annotation":"Calcium/calmodulin-dependent protein kinase type 1G; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates transcription factor CREB1."},{"id":"ENSMUSP00000100532","abundance":0.449,"rank":13858,"name":"Actl10","annotation":"Actin-like protein 10; Belongs to the actin family."},{"id":"ENSMUSP00000020204","abundance":0.449,"rank":13859,"name":"Ntn4","annotation":"Netrin-4; May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants."},{"id":"ENSMUSP00000034279","abundance":0.449,"rank":13860,"name":"Gse1","annotation":"Genetic suppressor element 1."},{"id":"ENSMUSP00000033610","abundance":0.449,"rank":13861,"name":"Nox1","annotation":"NADPH oxidase 1; Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism."},{"id":"ENSMUSP00000017974","abundance":0.449,"rank":13862,"name":"Dhx58","annotation":"Probable ATP-dependent RNA helicase DHX58; Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: compet [...] "},{"id":"ENSMUSP00000034751","abundance":0.449,"rank":13863,"name":"Gcnt3","annotation":"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3; Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I- branching enzyme activity by converting linear into branched poly-N- acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development."},{"id":"ENSMUSP00000022692","abundance":0.449,"rank":13864,"name":"Sftpc","annotation":"Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces."},{"id":"ENSMUSP00000028178","abundance":0.449,"rank":13865,"name":"Acvr1c","annotation":"Activin receptor type-1C; Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis."},{"id":"ENSMUSP00000105542","abundance":0.448,"rank":13866,"name":"Zfp442","annotation":"Zinc-finger protein in podocyte II."},{"id":"ENSMUSP00000080751","abundance":0.448,"rank":13867,"name":"Csmd1","annotation":"CUB and sushi domain-containing protein 1; Belongs to the CSMD family."},{"id":"ENSMUSP00000047771","abundance":0.448,"rank":13868,"name":"Atf5","annotation":"Cyclic AMP-dependent transcription factor ATF-5; Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'- C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and s [...] "},{"id":"ENSMUSP00000082856","abundance":0.448,"rank":13869,"name":"Ppcdc","annotation":"Phosphopantothenoylcysteine decarboxylase; Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'- phosphopantotheine (By similarity)."},{"id":"ENSMUSP00000065096","abundance":0.448,"rank":13870,"name":"Galnt10","annotation":"Polypeptide N-acetylgalactosaminyltransferase 10; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward Muc5Ac and EA2 peptide substrates (By similarity)."},{"id":"ENSMUSP00000127546","abundance":0.448,"rank":13871,"name":"Rab40c","annotation":"Ras-related protein Rab-40C; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins."},{"id":"ENSMUSP00000101967","abundance":0.448,"rank":13872,"name":"Olfr1331","annotation":"Olfactory receptor 1331."},{"id":"ENSMUSP00000040405","abundance":0.447,"rank":13873,"name":"Vwa1","annotation":"Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly."},{"id":"ENSMUSP00000023344","abundance":0.447,"rank":13874,"name":"Slc35a5","annotation":"Probable UDP-sugar transporter protein SLC35A5."},{"id":"ENSMUSP00000038527","abundance":0.447,"rank":13875,"name":"Cib2","annotation":"Calcium and integrin-binding family member 2; Calcium-binding protein critical for proper photoreceptor cell maintenance and function. Plays a role in intracellular calcium homeostasis by decreasing ATP-induced calcium release. May be involved in the mechanotransduction process (By similarity)."},{"id":"ENSMUSP00000110545","abundance":0.447,"rank":13876,"name":"Cfap53","annotation":"Cilia- and flagella-associated protein 53; May play a role in the beating of primary cilia and thereby be involved in the establishment of organ laterality during embryogenesis."},{"id":"ENSMUSP00000107367","abundance":0.447,"rank":13877,"name":"Tctn1","annotation":"Tectonic-1; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to rep [...] "},{"id":"ENSMUSP00000037024","abundance":0.447,"rank":13878,"name":"6820408C15Rik","annotation":"RIKEN cDNA 6820408C15 gene."},{"id":"ENSMUSP00000047652","abundance":0.446,"rank":13879,"name":"Dock3","annotation":"Dedicator of cytokinesis protein 3; Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of amyloid-beta APBA1 protein and lowers the rate of cell- substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion r [...] "},{"id":"ENSMUSP00000132644","abundance":0.446,"rank":13880,"name":"Magea5","annotation":"Melanoma antigen, family A, 5."},{"id":"ENSMUSP00000031347","abundance":0.446,"rank":13881,"name":"Rilpl2","annotation":"RILP-like protein 2; Involved in cell shape and neuronal morphogenesis, positively regulating the establishment and maintenance of dendritic spines (By similarity). Plays a role in cellular protein transport, including protein transport away from primary cilia. May function via activation of RAC1 and PAK1 (By similarity). Belongs to the RILPL family."},{"id":"ENSMUSP00000126498","abundance":0.446,"rank":13882,"name":"Adamts9","annotation":"A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9."},{"id":"ENSMUSP00000032754","abundance":0.446,"rank":13883,"name":"Sema4b","annotation":"Semaphorin-4B; Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons; Belongs to the semaphorin family."},{"id":"ENSMUSP00000066403","abundance":0.446,"rank":13884,"name":"Lonrf1","annotation":"LON peptidase N-terminal domain and RING finger protein 1."},{"id":"ENSMUSP00000114093","abundance":0.446,"rank":13885,"name":"Gask1b","annotation":"Golgi-associated kinase 1B; Belongs to the GASK family."},{"id":"ENSMUSP00000060027","abundance":0.446,"rank":13886,"name":"Guca1a","annotation":"Guanylyl cyclase-activating protein 1; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light."},{"id":"ENSMUSP00000075398","abundance":0.445,"rank":13887,"name":"Olfr1333","annotation":"Olfactory receptor Olfr1333."},{"id":"ENSMUSP00000103240","abundance":0.445,"rank":13888,"name":"Tbkbp1","annotation":"TANK-binding kinase 1-binding protein 1; Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Essential for the efficient induction of IRF-dependent transcription following infection with Sendai virus."},{"id":"ENSMUSP00000111048","abundance":0.445,"rank":13889,"name":"Ccnf","annotation":"Cyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication."},{"id":"ENSMUSP00000143705","abundance":0.445,"rank":13890,"name":"Rnf216","annotation":"E3 ubiquitin-protein ligase RNF216; Acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Promotes TNF and RIP mediated apoptosis."},{"id":"ENSMUSP00000040917","abundance":0.445,"rank":13891,"name":"Rfxap","annotation":"Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters."},{"id":"ENSMUSP00000094238","abundance":0.445,"rank":13892,"name":"Egflam","annotation":"Pikachurin; Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness."},{"id":"ENSMUSP00000002473","abundance":0.445,"rank":13893,"name":"Babam1","annotation":"BRISC and BRCA1-A complex member 1; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'- linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cl [...] "},{"id":"ENSMUSP00000016383","abundance":0.444,"rank":13894,"name":"Lonrf3","annotation":"LON peptidase N-terminal domain and RING finger protein 3."},{"id":"ENSMUSP00000002320","abundance":0.444,"rank":13895,"name":"Ppard","annotation":"Peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand (By similarity). Belongs to the [...] "},{"id":"ENSMUSP00000054638","abundance":0.444,"rank":13896,"name":"A430005L14Rik","annotation":"UPF0688 protein C1orf174 homolog."},{"id":"ENSMUSP00000054963","abundance":0.444,"rank":13897,"name":"Klhl11","annotation":"Kelch-like protein 11; Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation."},{"id":"ENSMUSP00000040083","abundance":0.444,"rank":13898,"name":"Ccno","annotation":"Cyclin-O; Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking (By similarity). May be involved in apoptosis in lymphoid cells; however, this result requires additional evidences in vivo. May be involved in oocyte meiotic resumption in oocytes. Belongs to the cyclin family."},{"id":"ENSMUSP00000062834","abundance":0.444,"rank":13899,"name":"Lao1","annotation":"Amine oxidase."},{"id":"ENSMUSP00000061408","abundance":0.444,"rank":13900,"name":"Olig1","annotation":"Oligodendrocyte transcription factor 1; Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube."},{"id":"ENSMUSP00000095410","abundance":0.444,"rank":13901,"name":"4931408C20Rik","annotation":"RIKEN cDNA 4931408C20 gene."},{"id":"ENSMUSP00000072107","abundance":0.444,"rank":13902,"name":"Grik1","annotation":"Glutamate receptor ionotropic, kainate 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus (B [...] "},{"id":"ENSMUSP00000133114","abundance":0.443,"rank":13903,"name":"Prr36","annotation":"Proline-rich 36."},{"id":"ENSMUSP00000141963","abundance":0.443,"rank":13904,"name":"Nme7","annotation":"Nucleoside diphosphate kinase 7; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family."},{"id":"ENSMUSP00000152486","abundance":0.443,"rank":13905,"name":"Noxred1","annotation":"NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase."},{"id":"ENSMUSP00000064892","abundance":0.443,"rank":13906,"name":"Prrc2b","annotation":"Protein PRRC2B."},{"id":"ENSMUSP00000057999","abundance":0.443,"rank":13907,"name":"A4galt","annotation":"Lactosylceramide 4-alpha-galactosyltransferase; Catalyzes the transfer of galactose from UDP-alpha-D- galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer. Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes; Belongs to the glycosyltransferase 32 family."},{"id":"ENSMUSP00000041701","abundance":0.443,"rank":13908,"name":"Thada","annotation":"Thyroid adenoma-associated protein homolog."},{"id":"ENSMUSP00000133341","abundance":0.443,"rank":13909,"name":"Ndst4","annotation":"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity. Belongs to the sulfotransferase 1 family. NDST subfamily."},{"id":"ENSMUSP00000052078","abundance":0.443,"rank":13910,"name":"Cdh20","annotation":"Cadherin-20; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity)."},{"id":"ENSMUSP00000133193","abundance":0.443,"rank":13911,"name":"Taar8c","annotation":"Trace amine-associated receptor 8c; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000099616","abundance":0.442,"rank":13912,"name":"Chrne","annotation":"Acetylcholine receptor subunit epsilon; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane."},{"id":"ENSMUSP00000003238","abundance":0.442,"rank":13913,"name":"Foxj2","annotation":"Forkhead box protein J2; Transcriptional activator. Able to bind to two different type of DNA binding sites."},{"id":"ENSMUSP00000033300","abundance":0.442,"rank":13914,"name":"Art1","annotation":"GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1; Has ADP-ribosyltransferase activity toward GLP1R. Belongs to the Arg-specific ADP-ribosyltransferase family."},{"id":"ENSMUSP00000045838","abundance":0.442,"rank":13915,"name":"Dusp10","annotation":"Dual specificity protein phosphatase 10; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000069832","abundance":0.441,"rank":13916,"name":"Magea2","annotation":"Melanoma antigen, family A, 2."},{"id":"ENSMUSP00000021532","abundance":0.441,"rank":13917,"name":"Snapc1","annotation":"snRNA-activating protein complex subunit 1; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)."},{"id":"ENSMUSP00000022095","abundance":0.441,"rank":13918,"name":"Irx4","annotation":"Iroquois-class homeodomain protein IRX-4; Likely to be an important mediator of ventricular differentiation during cardiac development; Belongs to the TALE/IRO homeobox family."},{"id":"ENSMUSP00000024916","abundance":0.441,"rank":13919,"name":"Lhcgr","annotation":"Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase."},{"id":"ENSMUSP00000065721","abundance":0.441,"rank":13920,"name":"Tbc1d22a","annotation":"TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s)."},{"id":"ENSMUSP00000115679","abundance":0.44,"rank":13921,"name":"Cep128","annotation":"Centrosomal protein of 128 kDa."},{"id":"ENSMUSP00000004036","abundance":0.44,"rank":13922,"name":"Efnb3","annotation":"Ephrin-B3; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, an [...] "},{"id":"ENSMUSP00000029423","abundance":0.44,"rank":13923,"name":"Serpini1","annotation":"Neuroserpin; Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable)."},{"id":"ENSMUSP00000097060","abundance":0.44,"rank":13924,"name":"Duox1","annotation":"Dual oxidase 1."},{"id":"ENSMUSP00000036035","abundance":0.44,"rank":13925,"name":"Foxn3","annotation":"Forkhead box protein N3; Acts as a transcriptional repressor. May be involved in DNA damage-inducible cell cycle arrests (checkpoints) (By similarity)."},{"id":"ENSMUSP00000034846","abundance":0.44,"rank":13926,"name":"1700017B05Rik","annotation":"Uncharacterized protein C15orf39 homolog."},{"id":"ENSMUSP00000019907","abundance":0.44,"rank":13927,"name":"Fbxo5","annotation":"F-box only protein 5; Regulator of APC activity during mitotic and meiotic cell cycle. During mitotic cell cycle plays a role as both substrate and inhibitor of APC- FZR1 complex. During G1 phase, plays a role as substrate of APC-FZR1 complex E3 ligase. Then switches as an inhibitor of APC-FZR1 complex during S and G2 leading to cell-cycle commitment. As APC inhibitor, prevents the degradation of APC substrates at multiple levels: by interacting with APC and blocking access of APC substrates to the D-box co-receptor, formed by FZR1 and ANAPC10; by suppressing ubiquitin ligation and cha [...] "},{"id":"ENSMUSP00000086745","abundance":0.44,"rank":13928,"name":"Col8a1","annotation":"Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis."},{"id":"ENSMUSP00000033290","abundance":0.44,"rank":13929,"name":"Dhx32","annotation":"Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32."},{"id":"ENSMUSP00000150737","abundance":0.44,"rank":13930,"name":"Olfr214","annotation":"Olfactory receptor MOR119-1."},{"id":"ENSMUSP00000062409","abundance":0.439,"rank":13931,"name":"Ifi205","annotation":"Interferon-activable protein 205-A; May act as a transcriptional regulator in the myeloid lineage. Inhibits cell growth via p53/TP53 and RB1-dependent and independent pathways (By similarity); Belongs to the HIN-200 family."},{"id":"ENSMUSP00000099760","abundance":0.439,"rank":13932,"name":"Mutyh","annotation":"Adenine DNA glycosylase; Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities."},{"id":"ENSMUSP00000065658","abundance":0.439,"rank":13933,"name":"Art2b","annotation":"T-cell ecto-ADP-ribosyltransferase 2; Has both NAD(+) glycohydrolase and ADP-ribosyltransferase activity."},{"id":"ENSMUSP00000145092","abundance":0.439,"rank":13934,"name":"Cyp26b1","annotation":"Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13- cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required  [...] "},{"id":"ENSMUSP00000082814","abundance":0.439,"rank":13935,"name":"Zkscan5","annotation":"Zinc finger protein with KRAB and SCAN domains 5; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000056882","abundance":0.438,"rank":13936,"name":"Fcer1a","annotation":"High affinity immunoglobulin epsilon receptor subunit alpha; Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines."},{"id":"ENSMUSP00000025805","abundance":0.438,"rank":13937,"name":"Cnih2","annotation":"Protein cornichon homolog 2; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by regulating their rates of activation, deactivation and desensitization. Blocks CACNG8-mediated resensitization of AMPA receptors."},{"id":"ENSMUSP00000025685","abundance":0.438,"rank":13938,"name":"Lipm","annotation":"Lipase member M; Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers (By similarity). Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000086921","abundance":0.438,"rank":13939,"name":"Il17d","annotation":"Interleukin 17D."},{"id":"ENSMUSP00000034240","abundance":0.438,"rank":13940,"name":"Kifc3","annotation":"Kinesin-like protein KIFC3; Minus-end microtubule-dependent motor protein. Involved in apically targeted transport. Required for zonula adherens maintenance."},{"id":"ENSMUSP00000128658","abundance":0.438,"rank":13941,"name":"Zfp667","annotation":"Zinc finger protein 667; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000054020","abundance":0.438,"rank":13942,"name":"Zfp3","annotation":"Zinc finger protein 3; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000065502","abundance":0.438,"rank":13943,"name":"Dcst1","annotation":"E3 ubiquitin-protein ligase DCST1; E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteosomal degradation thereby negatively regulating type-I-interferon signaling."},{"id":"ENSMUSP00000022640","abundance":0.438,"rank":13944,"name":"Adam7","annotation":"Disintegrin and metalloproteinase domain-containing protein 7; May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein."},{"id":"ENSMUSP00000115669","abundance":0.438,"rank":13945,"name":"Trim45","annotation":"Tripartite motif-containing protein 45; May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway."},{"id":"ENSMUSP00000023271","abundance":0.438,"rank":13946,"name":"Mroh4","annotation":"Maestro heat-like repeat family member 4."},{"id":"ENSMUSP00000093683","abundance":0.438,"rank":13947,"name":"1700049E17Rik1","annotation":"Tandem duplication of RIKEN cDNA 1700049E17 gene, gene 2."},{"id":"ENSMUSP00000132509","abundance":0.438,"rank":13948,"name":"Gm8104","annotation":"Predicted gene 8104."},{"id":"ENSMUSP00000130091","abundance":0.438,"rank":13949,"name":"1700049E17Rik2","annotation":"Tandem duplication of RIKEN cDNA 1700049E17 gene, gene 2."},{"id":"ENSMUSP00000138193","abundance":0.437,"rank":13950,"name":"Ano4","annotation":"Anoctamin-4; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity."},{"id":"ENSMUSP00000104197","abundance":0.437,"rank":13951,"name":"Pld2","annotation":"Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis."},{"id":"ENSMUSP00000011981","abundance":0.437,"rank":13952,"name":"Snapc2","annotation":"snRNA-activating protein complex subunit 2; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)."},{"id":"ENSMUSP00000033458","abundance":0.437,"rank":13953,"name":"3830403N18Rik","annotation":"RIKEN cDNA 3830403N18 gene."},{"id":"ENSMUSP00000103789","abundance":0.436,"rank":13954,"name":"Kmt2b","annotation":"Histone-lysine N-methyltransferase 2B; Histone methyltransferase that methylates 'Lys-4' of histone H3 (By similarity). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (By similarity). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (By similarity). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), [...] "},{"id":"ENSMUSP00000030627","abundance":0.436,"rank":13955,"name":"Rhd","annotation":"Blood group Rh(D) polypeptide; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane."},{"id":"ENSMUSP00000108573","abundance":0.436,"rank":13956,"name":"Mpeg1","annotation":"Macrophage-expressed gene 1 protein; Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores. By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence. Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogene [...] "},{"id":"ENSMUSP00000128086","abundance":0.436,"rank":13957,"name":"Gm17067","annotation":"Predicted gene 17067."},{"id":"ENSMUSP00000078795","abundance":0.436,"rank":13958,"name":"Znrf2","annotation":"E3 ubiquitin-protein ligase ZNRF2; May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates."},{"id":"ENSMUSP00000112568","abundance":0.435,"rank":13959,"name":"Ipmk","annotation":"Inositol polyphosphate multikinase; Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) first to inositol 1,3,4,5-tetrakisphosphate and then to inositol 1,3,4,5,6- pentakisphosphate (Ins(1,3,4,5,6)P5). Phosphorylates inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4). Phosphorylates glycero-3-phospho-1D-myo-inositol 4,5-bisphosphate to glycero-3- phospho-1D-myo-inositol 3,4,5-trisphosphate (By similarity). Plays an important role in MLKL-mediated necroptosis via its role in the biosynthesis of inositol pentakisphosph [...] "},{"id":"ENSMUSP00000149953","abundance":0.435,"rank":13960,"name":"Atr","annotation":"Serine/threonine-protein kinase ATR; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates Ser-139 of histone variant H2AX at sites of DNA damage, thereby regulating DNA damage response [...] "},{"id":"ENSMUSP00000132078","abundance":0.435,"rank":13961,"name":"Lats1","annotation":"Serine/threonine-protein kinase LATS1; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus  [...] "},{"id":"ENSMUSP00000110648","abundance":0.435,"rank":13962,"name":"Optn","annotation":"Optineurin; Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Plays a role in the activation of innate immune response during viral infection. Mechanistically, recruits TBK1 at the Golgi apparatus, promoting its trans-phosphorylation after RLR or TLR3 stimulation. In turn, activated TBK1 phosphorylates its downstream partner IRF3 to produce IFN-beta. Plays a neuroprotective role in the eye and [...] "},{"id":"ENSMUSP00000028188","abundance":0.434,"rank":13963,"name":"Fibcd1","annotation":"Fibrinogen C domain-containing protein 1; Acetyl group-binding receptor which shows a high-affinity and calcium-dependent binding to acetylated structures such as chitin, some N-acetylated carbohydrates, and amino acids, but not to their non- acetylated counterparts. Can facilitate the endocytosis of acetylated components (By similarity)."},{"id":"ENSMUSP00000023570","abundance":0.434,"rank":13964,"name":"Btg3","annotation":"Protein BTG3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase; Belongs to the BTG family."},{"id":"ENSMUSP00000020301","abundance":0.434,"rank":13965,"name":"Vsir","annotation":"V-type immunoglobulin domain-containing suppressor of T-cell activation; Immunoregulatory receptor which inhibits the T-cell response. May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling. May stimulate MMP14-mediated MMP2 activation (By similarity)."},{"id":"ENSMUSP00000055673","abundance":0.433,"rank":13966,"name":"Kcna5","annotation":"Potassium voltage-gated channel subfamily A member 5; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well [...] "},{"id":"ENSMUSP00000048829","abundance":0.433,"rank":13967,"name":"Cdh26","annotation":"Cadherin-like protein 26; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Ligand for integrins alpha-E/beta-7, ITGAE:ITGAB7, alpha-4/beta-7, ITGA4:ITGAB7 and alpha-4/beta-1, ITGA4:ITGAB1 through which modulates CD4(+) T cells activation."},{"id":"ENSMUSP00000048482","abundance":0.433,"rank":13968,"name":"Acmsd","annotation":"2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway; Belongs to the metallo-dependent [...] "},{"id":"ENSMUSP00000065633","abundance":0.433,"rank":13969,"name":"Arhgap20","annotation":"Rho GTPase-activating protein 20; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state."},{"id":"ENSMUSP00000034986","abundance":0.432,"rank":13970,"name":"Ube2cbp","annotation":"E3 ubiquitin-protein ligase E3D; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome."},{"id":"ENSMUSP00000149726","abundance":0.432,"rank":13971,"name":"Olfr38","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000128732","abundance":0.432,"rank":13972,"name":"Spaca6","annotation":"Sperm acrosome membrane-associated protein 6; Sperm protein potentially involved sperm-egg fusion."},{"id":"ENSMUSP00000050047","abundance":0.432,"rank":13973,"name":"E2f2","annotation":"Transcription factor E2F2; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner."},{"id":"ENSMUSP00000033442","abundance":0.432,"rank":13974,"name":"Igsf1","annotation":"Immunoglobulin superfamily member 1; Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B. Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription (By similarity)."},{"id":"ENSMUSP00000005933","abundance":0.432,"rank":13975,"name":"Klk1b16","annotation":"Kallikrein 1-related peptidase b16."},{"id":"ENSMUSP00000140546","abundance":0.432,"rank":13976,"name":"Casp8","annotation":"Caspase-8 subunit p10; Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CA [...] "},{"id":"ENSMUSP00000136547","abundance":0.431,"rank":13977,"name":"Zfp574","annotation":"Zinc finger protein 574; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000007249","abundance":0.431,"rank":13978,"name":"Slc44a4","annotation":"Choline transporter-like protein 4; Choline transporter that plays a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis. Belongs to the CTL (choline transporter-like) family."},{"id":"ENSMUSP00000080501","abundance":0.431,"rank":13979,"name":"Bpifb1","annotation":"BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS. May be involved in formation of the left-right axis in the node of the developing embryo."},{"id":"ENSMUSP00000124917","abundance":0.431,"rank":13980,"name":"E330034G19Rik","annotation":"RIKEN cDNA E330034G19 gene."},{"id":"ENSMUSP00000039648","abundance":0.431,"rank":13981,"name":"Atp13a2","annotation":"Cation-transporting ATPase 13A2; ATPase that plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Required for a proper lysosomal and mitochondrial maintenance. Regulates the autophagy- lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels."},{"id":"ENSMUSP00000090335","abundance":0.431,"rank":13982,"name":"Eya4","annotation":"Eyes absent homolog 4; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (By similarity); B [...] "},{"id":"ENSMUSP00000103378","abundance":0.431,"rank":13983,"name":"Gabbr2","annotation":"Gamma-aminobutyric acid type B receptor subunit 2; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] "},{"id":"ENSMUSP00000043376","abundance":0.43,"rank":13984,"name":"Rln1","annotation":"Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals."},{"id":"ENSMUSP00000080224","abundance":0.43,"rank":13985,"name":"Mgmt","annotation":"Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated; Belongs to the MGMT family."},{"id":"ENSMUSP00000045084","abundance":0.43,"rank":13986,"name":"Fam160a2","annotation":"FTS and Hook-interacting protein; Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex) (By similarity)."},{"id":"ENSMUSP00000147335","abundance":0.43,"rank":13987,"name":"Zfp791","annotation":"Zinc finger protein 791."},{"id":"ENSMUSP00000096811","abundance":0.43,"rank":13988,"name":"Defb26","annotation":"Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family."},{"id":"ENSMUSP00000046476","abundance":0.43,"rank":13989,"name":"Asb13","annotation":"Ankyrin repeat and SOCS box protein 13; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins."},{"id":"ENSMUSP00000129352","abundance":0.43,"rank":13990,"name":"Vmn2r52","annotation":"Vomeronasal 2, receptor 52."},{"id":"ENSMUSP00000032111","abundance":0.429,"rank":13991,"name":"Wbp1","annotation":"WW domain-binding protein 1."},{"id":"ENSMUSP00000026833","abundance":0.429,"rank":13992,"name":"Wdr24","annotation":"GATOR complex protein WDR24; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux."},{"id":"ENSMUSP00000002087","abundance":0.429,"rank":13993,"name":"Pnck","annotation":"Calcium/calmodulin-dependent protein kinase type 1B; Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. In vitro phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and activates CAMK1 (By similarity)."},{"id":"ENSMUSP00000130326","abundance":0.429,"rank":13994,"name":"Gm7233","annotation":"Predicted gene 7233."},{"id":"ENSMUSP00000132242","abundance":0.429,"rank":13995,"name":"Gm8126","annotation":"Predicted gene 8126."},{"id":"ENSMUSP00000107182","abundance":0.429,"rank":13996,"name":"Dennd5b","annotation":"DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity); Belongs to the RAB6IP1 family."},{"id":"ENSMUSP00000021757","abundance":0.429,"rank":13997,"name":"Aoah","annotation":"Acyloxyacyl hydrolase large subunit; Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (LPS). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses. In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria."},{"id":"ENSMUSP00000044352","abundance":0.428,"rank":13998,"name":"Pmch","annotation":"Neuropeptide-glutamic acid-isoleucine; MCH may act as a neurotransmitter or neuromodulator in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal."},{"id":"ENSMUSP00000034521","abundance":0.428,"rank":13999,"name":"Jhy","annotation":"Jhy protein; Required for the normal development of cilia in brain ependymal cells lining the ventricular surfaces."},{"id":"ENSMUSP00000152284","abundance":0.428,"rank":14000,"name":"Gpatch2l","annotation":"G patch domain-containing protein 2-like."},{"id":"ENSMUSP00000073150","abundance":0.428,"rank":14001,"name":"Pcdhga3","annotation":"Protocadherin gamma subfamily A, 3."},{"id":"ENSMUSP00000149593","abundance":0.428,"rank":14002,"name":"Olfr132","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000022532","abundance":0.428,"rank":14003,"name":"4930578I06Rik","annotation":"Uncharacterized protein C8orf74 homolog."},{"id":"ENSMUSP00000132092","abundance":0.428,"rank":14004,"name":"Dpy19l2","annotation":"Probable C-mannosyltransferase DPY19L2; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. Required during spermatogenesis for sperm head elongation and acrosome formation (By similarity)."},{"id":"ENSMUSP00000109960","abundance":0.428,"rank":14005,"name":"Kbtbd2","annotation":"Kelch repeat and BTB (POZ) domain-containing 2."},{"id":"ENSMUSP00000140610","abundance":0.428,"rank":14006,"name":"Mndal","annotation":"Myeloid cell nuclear differentiation antigen-like protein; Suppresses cell growth when expressed ectopically."},{"id":"ENSMUSP00000066341","abundance":0.427,"rank":14007,"name":"Magea8","annotation":"Melanoma antigen, family A, 8."},{"id":"ENSMUSP00000073107","abundance":0.427,"rank":14008,"name":"Usp17ld","annotation":"Ubiquitin carboxyl-terminal hydrolase 17-like protein D; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection; Belongs to the peptidase C19 family. USP17 subfamily."},{"id":"ENSMUSP00000078323","abundance":0.427,"rank":14009,"name":"Usp17lc","annotation":"Ubiquitin carboxyl-terminal hydrolase 17-like protein C; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Important for preimplantation stage embryonic development ; Belongs to the peptidase C19 family. USP17 subfamily."},{"id":"ENSMUSP00000039378","abundance":0.427,"rank":14010,"name":"Strc","annotation":"Stereocilin; Essential to the formation of horizontal top connectors between outer hair cell stereocilia."},{"id":"ENSMUSP00000109261","abundance":0.427,"rank":14011,"name":"Rtl5","annotation":"Retrotransposon Gag-like protein 5."},{"id":"ENSMUSP00000032322","abundance":0.427,"rank":14012,"name":"Lrp6","annotation":"Low-density lipoprotein receptor-related protein 6; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of  [...] "},{"id":"ENSMUSP00000094893","abundance":0.427,"rank":14013,"name":"Lrrc30","annotation":"Leucine-rich repeat-containing protein 30."},{"id":"ENSMUSP00000022501","abundance":0.427,"rank":14014,"name":"Gucy1b2","annotation":"Guanylate cyclase 1, soluble, beta 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family."},{"id":"ENSMUSP00000043753","abundance":0.427,"rank":14015,"name":"Ttll7","annotation":"Tubulin polyglutamylase TTLL7; Polyglutamylase which preferentially modifies beta-tubulin. Mediates both ATP- dependent initiation and elongation of polyglutamylation of microtubules. Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation ; Belongs to the tubulin--tyrosine ligase family."},{"id":"ENSMUSP00000064416","abundance":0.426,"rank":14016,"name":"Arl13a","annotation":"ADP-ribosylation factor-like protein 13A; Belongs to the small GTPase superfamily."},{"id":"ENSMUSP00000000161","abundance":0.426,"rank":14017,"name":"Itgb2l","annotation":"Integrin beta-2-like protein; During inflammatory stimulation, plays a role in retaining Cxcl13-expressing cells at the site of the inflammatory response."},{"id":"ENSMUSP00000110817","abundance":0.426,"rank":14018,"name":"Nrros","annotation":"Transforming growth factor beta activator LRRC33; Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF- beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF- beta-1 activated from one microglial cell to neighb [...] "},{"id":"ENSMUSP00000066737","abundance":0.426,"rank":14019,"name":"Npr3","annotation":"Atrial natriuretic peptide receptor 3; Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity."},{"id":"ENSMUSP00000047487","abundance":0.426,"rank":14020,"name":"Chsy1","annotation":"Chondroitin sulfate synthase 1; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer."},{"id":"ENSMUSP00000058611","abundance":0.425,"rank":14021,"name":"Naip5","annotation":"Baculoviral IAP repeat-containing protein 1e; Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram- negative bacteria such as L.pneumophila and P.aerugi [...] "},{"id":"ENSMUSP00000051864","abundance":0.425,"rank":14022,"name":"Atg9b","annotation":"Autophagy-related protein 9B; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle."},{"id":"ENSMUSP00000113952","abundance":0.425,"rank":14023,"name":"Zfp868","annotation":"Zinc finger protein 868."},{"id":"ENSMUSP00000128521","abundance":0.425,"rank":14024,"name":"Unc5d","annotation":"Netrin receptor UNC5D; Receptor for the netrin NTN4 that promotes neuronal cell survival. Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration (By similarity). Plays a role in the regulation of neuronal cell migration in the developing brain via its interaction with FLRT2. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when n [...] "},{"id":"ENSMUSP00000148230","abundance":0.425,"rank":14025,"name":"Gm29133","annotation":"Predicted gene 29133."},{"id":"ENSMUSP00000143508","abundance":0.425,"rank":14026,"name":"Mknk2","annotation":"MAP kinase-interacting serine/threonine-protein kinase 2; Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A- inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during sp [...] "},{"id":"ENSMUSP00000136870","abundance":0.425,"rank":14027,"name":"Gm14322","annotation":"Predicted gene 14322."},{"id":"ENSMUSP00000116617","abundance":0.425,"rank":14028,"name":"Gm14418","annotation":"Predicted gene 14322."},{"id":"ENSMUSP00000031222","abundance":0.425,"rank":14029,"name":"Enam","annotation":"Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation."},{"id":"ENSMUSP00000013886","abundance":0.425,"rank":14030,"name":"Ppp1r12c","annotation":"Protein phosphatase 1 regulatory subunit 12C; Regulates myosin phosphatase activity."},{"id":"ENSMUSP00000102167","abundance":0.424,"rank":14031,"name":"Ccp110","annotation":"Centriolar coiled-coil protein of 110 kDa; Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via [...] "},{"id":"ENSMUSP00000125129","abundance":0.424,"rank":14032,"name":"5430401F13Rik","annotation":"RIKEN cDNA 5430401F13 gene."},{"id":"ENSMUSP00000123949","abundance":0.424,"rank":14033,"name":"Gm6619","annotation":"Predicted gene 6619."},{"id":"ENSMUSP00000130518","abundance":0.424,"rank":14034,"name":"Cd200","annotation":"OX-2 membrane glycoprotein; Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity)."},{"id":"ENSMUSP00000067022","abundance":0.424,"rank":14035,"name":"Adamts15","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 15."},{"id":"ENSMUSP00000133637","abundance":0.424,"rank":14036,"name":"Adamtsl3","annotation":"ADAMTS-like 3."},{"id":"ENSMUSP00000047992","abundance":0.423,"rank":14037,"name":"Tram2","annotation":"Translocating chain-associated membrane protein 2; Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT)."},{"id":"ENSMUSP00000011178","abundance":0.423,"rank":14038,"name":"Slc5a1","annotation":"Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules."},{"id":"ENSMUSP00000155166","abundance":0.423,"rank":14039,"name":"Enthd1","annotation":"ENTH domain-containing 1."},{"id":"ENSMUSP00000113676","abundance":0.423,"rank":14040,"name":"Simc1","annotation":"SUMO-interacting motifs-containing 1."},{"id":"ENSMUSP00000144664","abundance":0.423,"rank":14041,"name":"1520401A03Rik","annotation":"RIKEN cDNA 1520401A03 gene."},{"id":"ENSMUSP00000059720","abundance":0.423,"rank":14042,"name":"Nsun3","annotation":"tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial; Mitochondrial tRNA methyltransferase that mediates methylation of cytosine to 5-methylcytosine (m5C) at position 34 of mt- tRNA(Met). mt-tRNA(Met) methylation at cytosine(34) takes place at the wobble position of the anticodon and initiates the formation of 5- formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation; Belongs to the class I-like SAM-bind [...] "},{"id":"ENSMUSP00000152038","abundance":0.423,"rank":14043,"name":"Ttc9","annotation":"Tetratricopeptide repeat protein 9A; Belongs to the TTC9 family."},{"id":"ENSMUSP00000143202","abundance":0.423,"rank":14044,"name":"Fam220a-2","annotation":"Family with sequence similarity 220, member A."},{"id":"ENSMUSP00000126480","abundance":0.423,"rank":14045,"name":"Fam220a","annotation":"Protein FAM220A; May negatively regulate STAT3."},{"id":"ENSMUSP00000144128","abundance":0.423,"rank":14046,"name":"Zfp825","annotation":"Zinc finger protein 825."},{"id":"ENSMUSP00000051979","abundance":0.422,"rank":14047,"name":"Zfp784","annotation":"Zinc finger protein 784; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000022353","abundance":0.422,"rank":14048,"name":"Mss51","annotation":"Putative protein MSS51 homolog, mitochondrial."},{"id":"ENSMUSP00000062915","abundance":0.422,"rank":14049,"name":"Tmprss11c","annotation":"Transmembrane protease serine 11C non-catalytic chain; Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro."},{"id":"ENSMUSP00000074394","abundance":0.422,"rank":14050,"name":"Tacc3","annotation":"Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). May be involved in the control of cell  [...] "},{"id":"ENSMUSP00000154207","abundance":0.422,"rank":14051,"name":"Zfp870","annotation":"Zinc finger protein 870."},{"id":"ENSMUSP00000069616","abundance":0.421,"rank":14052,"name":"Egr1","annotation":"Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'- GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor form [...] "},{"id":"ENSMUSP00000022136","abundance":0.421,"rank":14053,"name":"Rad17","annotation":"Cell cycle checkpoint protein RAD17; Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination (By similarity). Essential for embryonic development. May be involved in homologous recombination; Belongs to the rad17/RAD24 family."},{"id":"ENSMUSP00000023238","abundance":0.421,"rank":14054,"name":"Gsdmd","annotation":"Gasdermin-D, C-terminal; [Gasdermin-D, N-terminal]: Promotes pyroptosis in response to microbial infection and danger signals. Produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids, including monophosphorylated phosphatidylinositols, such as phosphatidylinositol 4-phosphate, bisphosphorylated phosphatidylinositols, such as phosphatidylinositol (4,5)-bisphosphate [...] "},{"id":"ENSMUSP00000151053","abundance":0.421,"rank":14055,"name":"Olfr1042","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000020323","abundance":0.421,"rank":14056,"name":"Avpr1a","annotation":"Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Involved in social memory formation."},{"id":"ENSMUSP00000096214","abundance":0.421,"rank":14057,"name":"Zfp827","annotation":"Zinc finger protein 827; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000045562","abundance":0.421,"rank":14058,"name":"Clcf1","annotation":"Cardiotrophin-like cytokine factor 1; In complex with CRLF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (By similarity). Also stimulates B-cells. Binds to and activates the ILST/gp130 receptor."},{"id":"ENSMUSP00000034316","abundance":0.421,"rank":14059,"name":"Map3k21","annotation":"Mitogen-activated protein kinase kinase kinase 21; Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways (By similarity)."},{"id":"ENSMUSP00000020118","abundance":0.421,"rank":14060,"name":"Dusp6","annotation":"Dual specificity protein phosphatase 6; Inactivates MAP kinases. Has a specificity for the ERK family (By similarity). Plays an important role in alleviating acute postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain ; Belongs to the protein-tyrosine phosphatase family. Non- receptor c [...] "},{"id":"ENSMUSP00000003290","abundance":0.421,"rank":14061,"name":"Bcl2l12","annotation":"BCL2-like 12 (proline-rich)."},{"id":"ENSMUSP00000037401","abundance":0.421,"rank":14062,"name":"Tbx10","annotation":"T-box transcription factor TBX10; Probable transcriptional regulator involved in developmental processes."},{"id":"ENSMUSP00000082168","abundance":0.421,"rank":14063,"name":"Mex3b","annotation":"RNA-binding protein MEX3B; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms (By similarity)."},{"id":"ENSMUSP00000156375","abundance":0.421,"rank":14064,"name":"Fst","annotation":"Follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH)."},{"id":"ENSMUSP00000146529","abundance":0.421,"rank":14065,"name":"Olfr1432","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000054371","abundance":0.42,"rank":14066,"name":"Pcdhb8","annotation":"Protocadherin beta-8; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain."},{"id":"ENSMUSP00000038170","abundance":0.42,"rank":14067,"name":"Hrh2","annotation":"Histamine H2 receptor; The H2 subclass of histamine receptors mediates gastric acid secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000103391","abundance":0.42,"rank":14068,"name":"Tulp2","annotation":"Tubby-related protein 2."},{"id":"ENSMUSP00000047681","abundance":0.42,"rank":14069,"name":"Fam124a","annotation":"Family with sequence similarity 124, member A."},{"id":"ENSMUSP00000143851","abundance":0.42,"rank":14070,"name":"Tex26","annotation":"Testis-expressed protein 26."},{"id":"ENSMUSP00000022826","abundance":0.42,"rank":14071,"name":"Fitm1","annotation":"Fat storage-inducing transmembrane protein 1; Plays an important role in lipid droplet accumulation."},{"id":"ENSMUSP00000086052","abundance":0.419,"rank":14072,"name":"Htr1d","annotation":"5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] "},{"id":"ENSMUSP00000067877","abundance":0.419,"rank":14073,"name":"Btla","annotation":"B- and T-lymphocyte attenuator; Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2. May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14. In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells."},{"id":"ENSMUSP00000075094","abundance":0.419,"rank":14074,"name":"Nfatc2ip","annotation":"NFATC2-interacting protein; In T-helper 2 (Th2) cells, regulates the magnitude of NFAT- driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly- SUMO chains by UBE2I/UBC9."},{"id":"ENSMUSP00000151806","abundance":0.418,"rank":14075,"name":"Olfr170","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000132219","abundance":0.418,"rank":14076,"name":"Adamts3","annotation":"A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3."},{"id":"ENSMUSP00000066520","abundance":0.418,"rank":14077,"name":"Abhd16b","annotation":"Protein ABHD16B; Belongs to the AB hydrolase superfamily. ABHD16 family."},{"id":"ENSMUSP00000067680","abundance":0.418,"rank":14078,"name":"Klf13","annotation":"Krueppel-like factor 13; Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage."},{"id":"ENSMUSP00000095034","abundance":0.418,"rank":14079,"name":"Rsph3a","annotation":"Radial spoke head protein 3 homolog A; Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity)."},{"id":"ENSMUSP00000028148","abundance":0.418,"rank":14080,"name":"Fpgs","annotation":"Folylpolyglutamate synthase, mitochondrial; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Dihydrofolate, tetrahydrofolate, 5,10- methylenetetrahydrofolate, 10-formyltetrahydrofolate and 5- formyltetrahydrofolate are the best substrates. Folic acid and 5- methyltetrahydrofolate can also act [...] "},{"id":"ENSMUSP00000039642","abundance":0.418,"rank":14081,"name":"Ccdc27","annotation":"Coiled-coil domain-containing protein 27."},{"id":"ENSMUSP00000090020","abundance":0.418,"rank":14082,"name":"Tspear","annotation":"Thrombospondin-type laminin G domain and EAR repeat-containing protein; Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system."},{"id":"ENSMUSP00000016279","abundance":0.417,"rank":14083,"name":"N4bp2l1","annotation":"NEDD4-binding protein 2-like 1."},{"id":"ENSMUSP00000040929","abundance":0.417,"rank":14084,"name":"Pnmal1","annotation":"Paraneoplastic antigen-like protein 8A; Belongs to the PNMA family."},{"id":"ENSMUSP00000129503","abundance":0.417,"rank":14085,"name":"Mnx1","annotation":"Motor neuron and pancreas homeobox protein 1; Putative transcription factor involved in pancreas development and function."},{"id":"ENSMUSP00000066515","abundance":0.417,"rank":14086,"name":"B4galt6","annotation":"Beta-1,4-galactosyltransferase 6; Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation."},{"id":"ENSMUSP00000092462","abundance":0.417,"rank":14087,"name":"Vmn2r32","annotation":"Vomeronasal 2, receptor 32."},{"id":"ENSMUSP00000128247","abundance":0.417,"rank":14088,"name":"Tbx22","annotation":"T-box transcription factor TBX22; Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis."},{"id":"ENSMUSP00000095713","abundance":0.417,"rank":14089,"name":"Pigo","annotation":"GPI ethanolamine phosphate transferase 3; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI- anchor to the C-terminus of the proteins by an amide bond. Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily."},{"id":"ENSMUSP00000145042","abundance":0.416,"rank":14090,"name":"Olfr774","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000126205","abundance":0.416,"rank":14091,"name":"Rnf14","annotation":"E3 ubiquitin-protein ligase RNF14; Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (By similarity)."},{"id":"ENSMUSP00000031410","abundance":0.416,"rank":14092,"name":"Mapkapk5","annotation":"MAP kinase-activated protein kinase 5; Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3' [...] "},{"id":"ENSMUSP00000095314","abundance":0.416,"rank":14093,"name":"Pikfyve","annotation":"1-phosphatidylinositol 3-phosphate 5-kinase; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. The product of the reaction it catalyzes functions as an important regulator of vacuole homeostasis perhaps by controlling membrane flux to and/or from the vacuole."},{"id":"ENSMUSP00000140269","abundance":0.416,"rank":14094,"name":"Gsdmc4","annotation":"Gasdermin-C4; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family."},{"id":"ENSMUSP00000093245","abundance":0.416,"rank":14095,"name":"Adgrv1","annotation":"Adhesion G-protein coupled receptor V1; G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing th [...] "},{"id":"ENSMUSP00000128613","abundance":0.416,"rank":14096,"name":"Armh1","annotation":"Armadillo-like helical domain-containing 1."},{"id":"ENSMUSP00000042004","abundance":0.416,"rank":14097,"name":"Eps8l3","annotation":"Epidermal growth factor receptor kinase substrate 8-like protein 3."},{"id":"ENSMUSP00000045805","abundance":0.415,"rank":14098,"name":"Zfp174","annotation":"Zinc finger protein 174."},{"id":"ENSMUSP00000021548","abundance":0.415,"rank":14099,"name":"Rdh12","annotation":"Retinol dehydrogenase 12; Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans- retinal. Shows very weak activity toward 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal (By similarity). Plays an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity t [...] "},{"id":"ENSMUSP00000043153","abundance":0.415,"rank":14100,"name":"Amh","annotation":"Muellerian-inhibiting factor; This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin."},{"id":"ENSMUSP00000024099","abundance":0.414,"rank":14101,"name":"Ache","annotation":"Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft."},{"id":"ENSMUSP00000121301","abundance":0.414,"rank":14102,"name":"Zfp993","annotation":"Zinc finger protein 993."},{"id":"ENSMUSP00000099830","abundance":0.414,"rank":14103,"name":"Mmadhc","annotation":"Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial; Involved in cobalamin metabolism. Plays a role in regulating the biosynthesis of two coenzymes, methylcobalamin and adenosylcobalamin. Plays a role in regulating the proportion of methylcobalamin and adenosylcobalamin. Promotes oxidation of cob(II)alamin bound to MMACHC."},{"id":"ENSMUSP00000031254","abundance":0.414,"rank":14104,"name":"Klhl8","annotation":"Kelch-like protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN."},{"id":"ENSMUSP00000070216","abundance":0.414,"rank":14105,"name":"Zfp46","annotation":"Zinc finger protein 436; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000074291","abundance":0.414,"rank":14106,"name":"Olfr512","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000112116","abundance":0.414,"rank":14107,"name":"Mthfsd","annotation":"Methenyltetrahydrofolate synthase domain-containing protein."},{"id":"ENSMUSP00000034969","abundance":0.414,"rank":14108,"name":"Lctl","annotation":"Lactase-like protein; Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily."},{"id":"ENSMUSP00000127094","abundance":0.413,"rank":14109,"name":"Nxnl1","annotation":"Nucleoredoxin-like protein 1; May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods."},{"id":"ENSMUSP00000030088","abundance":0.413,"rank":14110,"name":"Bspry","annotation":"B box and SPRY domain-containing protein; May regulate epithelial calcium transport by inhibiting TRPV5 activity."},{"id":"ENSMUSP00000062734","abundance":0.413,"rank":14111,"name":"Fam110b","annotation":"Protein FAM110B."},{"id":"ENSMUSP00000128731","abundance":0.413,"rank":14112,"name":"Rbak","annotation":"RB-associated KRAB zinc finger protein; May repress E2F-dependent transcription. May promote AR- dependent transcription."},{"id":"ENSMUSP00000050597","abundance":0.413,"rank":14113,"name":"Cep112","annotation":"Centrosomal protein of 112 kDa."},{"id":"ENSMUSP00000021287","abundance":0.413,"rank":14114,"name":"Cfap52","annotation":"Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family."},{"id":"ENSMUSP00000104190","abundance":0.413,"rank":14115,"name":"Vmn2r49","annotation":"Vomeronasal 2, receptor 49."},{"id":"ENSMUSP00000129463","abundance":0.413,"rank":14116,"name":"Cables1","annotation":"CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity)."},{"id":"ENSMUSP00000029674","abundance":0.413,"rank":14117,"name":"Efna4","annotation":"Ephrin-A4; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils (By similarity); Belongs to the ephrin family."},{"id":"ENSMUSP00000022782","abundance":0.412,"rank":14118,"name":"Lrp10","annotation":"Low-density lipoprotein receptor-related protein 10; Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver."},{"id":"ENSMUSP00000147837","abundance":0.412,"rank":14119,"name":"Best2","annotation":"Bestrophin-2; Forms calcium-sensitive chloride channels. Permeable to bicarbonate."},{"id":"ENSMUSP00000027368","abundance":0.412,"rank":14120,"name":"Slc11a1","annotation":"Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis  [...] "},{"id":"ENSMUSP00000101372","abundance":0.412,"rank":14121,"name":"Aadacl4fm5","annotation":"AADACL4 family member 5."},{"id":"ENSMUSP00000020986","abundance":0.412,"rank":14122,"name":"Dnajc27","annotation":"DnaJ homolog subfamily C member 27; GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000124459","abundance":0.411,"rank":14123,"name":"Gpc2","annotation":"Secreted glypican-2; Cell surface proteoglycan that bears heparan sulfate. May fulfill a function related to the motile behaviors of developing neurons (By similarity); Belongs to the glypican family."},{"id":"ENSMUSP00000023387","abundance":0.411,"rank":14124,"name":"Qtrt2","annotation":"Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)."},{"id":"ENSMUSP00000043210","abundance":0.411,"rank":14125,"name":"Katnal1","annotation":"Katanin p60 ATPase-containing subunit A-like 1; Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays. Has microtubule- severing activity in vitro (By similarity). Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily."},{"id":"ENSMUSP00000065713","abundance":0.411,"rank":14126,"name":"Kcnk18","annotation":"Potassium channel subfamily K member 18; Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. May function as background potassium channel that sets the resting membrane potential. Channel activity is directly activated by calcium signal. Activated by the G(q)-protein coupled receptor pathway. The calcium signal robustly activates the channel via calcineurin, whereas the anchoring of 14-3- 3/YWHAH interferes with the return of the current to the resting state after activation. Inhibited also by arachidonic acid and other naturally occurring [...] "},{"id":"ENSMUSP00000030328","abundance":0.411,"rank":14127,"name":"Aadacl4fm1","annotation":"Arylacetamide deacetylase-like 4."},{"id":"ENSMUSP00000095385","abundance":0.411,"rank":14128,"name":"Arid5a","annotation":"AT-rich interactive domain-containing protein 5A; DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes (By similarity). May positively regulate chondrocyte- specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention. Can repress ESR1- mediated transcriptional activation; proposed to act as corepressor for selective nucl [...] "},{"id":"ENSMUSP00000063954","abundance":0.411,"rank":14129,"name":"Tas2r130","annotation":"Taste receptor type 2 member 7; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5."},{"id":"ENSMUSP00000142535","abundance":0.411,"rank":14130,"name":"Fam241a","annotation":"Uncharacterized protein FAM241A."},{"id":"ENSMUSP00000152890","abundance":0.411,"rank":14131,"name":"Prl3d1","annotation":"Prolactin-3D1; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000079032","abundance":0.41,"rank":14132,"name":"Adam26b","annotation":"A disintegrin and metallopeptidase domain 26B."},{"id":"ENSMUSP00000101375","abundance":0.41,"rank":14133,"name":"Aadacl3","annotation":"Arylacetamide deacetylase-like 3."},{"id":"ENSMUSP00000110769","abundance":0.41,"rank":14134,"name":"Muc20","annotation":"Mucin-20; May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression (By similarity)."},{"id":"ENSMUSP00000061704","abundance":0.41,"rank":14135,"name":"Emid1","annotation":"EMI domain-containing protein 1."},{"id":"ENSMUSP00000123090","abundance":0.41,"rank":14136,"name":"Dusp15","annotation":"Dual specificity protein phosphatase 15; May dephosphorylate MAPK13, ATF2, ERBB3, PDGFRB and SNX6 (By similarity)."},{"id":"ENSMUSP00000099792","abundance":0.41,"rank":14137,"name":"Tnip1","annotation":"TNFAIP3-interacting protein 1; Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B- dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1- dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this f [...] "},{"id":"ENSMUSP00000023100","abundance":0.41,"rank":14138,"name":"Srebf2","annotation":"Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes."},{"id":"ENSMUSP00000072709","abundance":0.409,"rank":14139,"name":"Slc6a2","annotation":"Sodium-dependent noradrenaline transporter; Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A2 subfamily."},{"id":"ENSMUSP00000020212","abundance":0.409,"rank":14140,"name":"Cep83","annotation":"Centrosomal protein of 83 kDa; Component of the distal appendage region of the centriole involved in the initiation of primary cilium assembly. May collaborate with IFT20 in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium during the initiation of primary cilium assembly; Belongs to the CEP83 family."},{"id":"ENSMUSP00000039819","abundance":0.409,"rank":14141,"name":"Csgalnact2","annotation":"Chondroitin sulfate N-acetylgalactosaminyltransferase 2; Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains (By similarity)."},{"id":"ENSMUSP00000028858","abundance":0.408,"rank":14142,"name":"Bub1","annotation":"Mitotic checkpoint serine/threonine-protein kinase BUB1; Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromat [...] "},{"id":"ENSMUSP00000063050","abundance":0.408,"rank":14143,"name":"Ccdc158","annotation":"Coiled-coil domain-containing protein 158."},{"id":"ENSMUSP00000002926","abundance":0.407,"rank":14144,"name":"Pla1a","annotation":"Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production (By similarity); Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000035644","abundance":0.407,"rank":14145,"name":"Gcfc2","annotation":"GC-rich sequence DNA-binding factor 2; Factor that represses transcription. It binds to the GC-rich sequences (5'-GCGGGGC-3') present in the epidermal growth factor receptor, beta-actin, and calcium-dependent protease promoters. Involved in pre-mRNA splicing through regulating spliceosome C complex formation. May play a role during late-stage splicing events and turnover of excised inrons (By similarity); Belongs to the GCF family."},{"id":"ENSMUSP00000095962","abundance":0.407,"rank":14146,"name":"Fbxw18","annotation":"F-box and WD-40 domain protein 18."},{"id":"ENSMUSP00000080737","abundance":0.407,"rank":14147,"name":"Mamld1","annotation":"Mastermind-like domain-containing protein 1; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ (By similarity). Required for testosterone production. Belongs to the mastermind family."},{"id":"ENSMUSP00000055799","abundance":0.407,"rank":14148,"name":"Gm5065","annotation":"Galectin-related protein B; Does not bind lactose, and may not bind carbohydrates."},{"id":"ENSMUSP00000102880","abundance":0.407,"rank":14149,"name":"Gm27029","annotation":"Predicted gene, 27029."},{"id":"ENSMUSP00000146224","abundance":0.407,"rank":14150,"name":"Zfp780b","annotation":"Zinc finger protein 780B."},{"id":"ENSMUSP00000079579","abundance":0.407,"rank":14151,"name":"Prl3d2","annotation":"Prolactin family 3, subfamily d, member 1."},{"id":"ENSMUSP00000073286","abundance":0.407,"rank":14152,"name":"Prl3d3","annotation":"Prolactin family 3, subfamily d, member 3."},{"id":"ENSMUSP00000046152","abundance":0.406,"rank":14153,"name":"Bcl9","annotation":"B-cell CLL/lymphoma 9 protein; Promotes beta-catenin's transcriptional activity. Involved in signal transduction through the Wnt pathway (By similarity)."},{"id":"ENSMUSP00000069182","abundance":0.406,"rank":14154,"name":"Pard6g","annotation":"Partitioning defective 6 homolog gamma; Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Belongs to the PAR6 family."},{"id":"ENSMUSP00000125288","abundance":0.406,"rank":14155,"name":"Tc2n","annotation":"Tandem C2 domains nuclear protein."},{"id":"ENSMUSP00000025844","abundance":0.406,"rank":14156,"name":"Ctsw","annotation":"Cathepsin W; May have a specific function in the mechanism or regulation of T-cell cytolytic activity; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000037854","abundance":0.406,"rank":14157,"name":"Plcl1","annotation":"Inactive phospholipase C-like protein 1; Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol. Component in the phospho- dependent endocytosis process of GABA A receptor. Acts as an inhibitor of PPP1C (By similarity). Involved in the assembly and/or the trafficking of gamma-2 subunit-containing GABA A receptors."},{"id":"ENSMUSP00000038884","abundance":0.406,"rank":14158,"name":"Htr5a","annotation":"5-hydroxytryptamine receptor 5A; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins."},{"id":"ENSMUSP00000096939","abundance":0.405,"rank":14159,"name":"Plxnc1","annotation":"Plexin-C1; Receptor for SEMA7A, for vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8 (By similarity)."},{"id":"ENSMUSP00000152199","abundance":0.405,"rank":14160,"name":"Platr25","annotation":"Pluripotency-associated transcript 25."},{"id":"ENSMUSP00000098827","abundance":0.405,"rank":14161,"name":"Cpxcr1","annotation":"CPX chromosomal region candidate gene 1 protein homolog."},{"id":"ENSMUSP00000022078","abundance":0.405,"rank":14162,"name":"Rhobtb3","annotation":"Rho-related BTB domain-containing protein 3; Rab9-regulated ATPase required for endosome to Golgi transport. Involved in transport vesicle docking at the Golgi complex, possibly by participating in release M6PRBP1/TIP47 from vesicles to permit their efficient docking and fusion at the Golgi. Specifically binds Rab9, but not other Rab proteins. Has low intrinsic ATPase activity due to autoinhibition, which is relieved by Rab9 (By similarity)."},{"id":"ENSMUSP00000044491","abundance":0.405,"rank":14163,"name":"Stard8","annotation":"StAR-related lipid transfer protein 8; Accelerates GTPase activity of RHOA and CDC42, but not RAC1. Stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate by PLCD1 (By similarity)."},{"id":"ENSMUSP00000077546","abundance":0.405,"rank":14164,"name":"Pirb","annotation":"Leukocyte immunoglobulin-like receptor subfamily B member 3; May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine- based inhibitor motifs (ITIM)."},{"id":"ENSMUSP00000020378","abundance":0.405,"rank":14165,"name":"Best3","annotation":"Bestrophin-3; Forms calcium-sensitive chloride channels. Permeable to bicarbonate (By similarity); Belongs to the bestrophin family."},{"id":"ENSMUSP00000096957","abundance":0.405,"rank":14166,"name":"Arrdc3","annotation":"Arrestin domain-containing protein 3; Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes. Belongs to the arrestin family."},{"id":"ENSMUSP00000009220","abundance":0.405,"rank":14167,"name":"Zmat5","annotation":"Zinc finger matrin-type protein 5."},{"id":"ENSMUSP00000045676","abundance":0.405,"rank":14168,"name":"Gmip","annotation":"GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA."},{"id":"ENSMUSP00000137523","abundance":0.404,"rank":14169,"name":"Sulf1","annotation":"Extracellular sulfatase Sulf-1; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation (By similarity)."},{"id":"ENSMUSP00000141989","abundance":0.404,"rank":14170,"name":"Pcdha3","annotation":"Protocadherin alpha 3."},{"id":"ENSMUSP00000148336","abundance":0.404,"rank":14171,"name":"Large1","annotation":"LARGE xylosyl- and glucuronyltransferase 1; Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongat [...] "},{"id":"ENSMUSP00000067027","abundance":0.404,"rank":14172,"name":"Ston1","annotation":"Stonin-1; May be involved in the endocytic machinery."},{"id":"ENSMUSP00000083463","abundance":0.403,"rank":14173,"name":"Vmn2r42","annotation":"Putative pheromone receptor."},{"id":"ENSMUSP00000108493","abundance":0.403,"rank":14174,"name":"Wdr38","annotation":"WD repeat-containing protein 38."},{"id":"ENSMUSP00000144815","abundance":0.403,"rank":14175,"name":"Olfr1356","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000001456","abundance":0.403,"rank":14176,"name":"Tmem79","annotation":"Transmembrane protein 79; Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation."},{"id":"ENSMUSP00000091286","abundance":0.403,"rank":14177,"name":"Zfp651","annotation":"Zinc finger protein 651."},{"id":"ENSMUSP00000026208","abundance":0.403,"rank":14178,"name":"Abcc2","annotation":"Canalicular multispecific organic anion transporter 1; Mediates hepatobiliary excretion of numerous organic anions and conjugated organic anions such as methotrexate, 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Also transports sulfated bile salt such as taurolithocholate sulfate. May function as a cellular cisplatin transporter; Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily."},{"id":"ENSMUSP00000107228","abundance":0.403,"rank":14179,"name":"Lrrc55","annotation":"Leucine-rich repeat-containing protein 55; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity)."},{"id":"ENSMUSP00000127071","abundance":0.403,"rank":14180,"name":"Gbgt1","annotation":"Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1; Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens. Conversely, it diminishes Shiga toxins susceptibility. Belongs to the glycosyltransferase 6 family."},{"id":"ENSMUSP00000123931","abundance":0.403,"rank":14181,"name":"Cd46","annotation":"Membrane cofactor protein; May be involved in the fusion of the spermatozoa with the oocyte during fertilization."},{"id":"ENSMUSP00000096175","abundance":0.403,"rank":14182,"name":"Zfp280d","annotation":"Zinc finger protein 280D; May function as a transcription factor."},{"id":"ENSMUSP00000126984","abundance":0.403,"rank":14183,"name":"Dusp7","annotation":"Dual specificity protein phosphatase 7; Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to  [...] "},{"id":"ENSMUSP00000022707","abundance":0.403,"rank":14184,"name":"Gpc5","annotation":"Secreted glypican-5; Cell surface proteoglycan that bears heparan sulfate."},{"id":"ENSMUSP00000113259","abundance":0.403,"rank":14185,"name":"Prr14l","annotation":"Proline-rich 14-like."},{"id":"ENSMUSP00000027231","abundance":0.402,"rank":14186,"name":"Slc9a2","annotation":"Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family."},{"id":"ENSMUSP00000050211","abundance":0.402,"rank":14187,"name":"Mtss2","annotation":"Protein MTSS 2; Involved in plasma membrane dynamics. Potentiated PDGF- mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling."},{"id":"ENSMUSP00000152662","abundance":0.402,"rank":14188,"name":"Gm49359","annotation":"Predicted gene, 49359."},{"id":"ENSMUSP00000041821","abundance":0.402,"rank":14189,"name":"Zkscan2","annotation":"Zinc finger with KRAB and SCAN domains 2."},{"id":"ENSMUSP00000046558","abundance":0.402,"rank":14190,"name":"Igsf21","annotation":"Immunoglobulin superfamily member 21; Involved in synaptic inhibition in the brain. Selectively regulates inhibitory presynaptic differentiation through interacting with presynaptic NRXN2."},{"id":"ENSMUSP00000149717","abundance":0.402,"rank":14191,"name":"Olfr1512","annotation":"Olfactory receptor MOR223-5."},{"id":"ENSMUSP00000025425","abundance":0.402,"rank":14192,"name":"Cep192","annotation":"Centrosomal protein 192."},{"id":"ENSMUSP00000038369","abundance":0.402,"rank":14193,"name":"Tmcc2","annotation":"Transmembrane and coiled-coil domains protein 2; May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE."},{"id":"ENSMUSP00000102786","abundance":0.402,"rank":14194,"name":"Mpp3","annotation":"MAGUK p55 subfamily member 3; Belongs to the MAGUK family."},{"id":"ENSMUSP00000000450","abundance":0.401,"rank":14195,"name":"Pparg","annotation":"Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] "},{"id":"ENSMUSP00000068044","abundance":0.401,"rank":14196,"name":"Xlr","annotation":"X-linked lymphocyte-regulated protein PM1."},{"id":"ENSMUSP00000023615","abundance":0.401,"rank":14197,"name":"Vps26c","annotation":"Vacuolar protein sorting-associated protein 26C; Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of nu [...] "},{"id":"ENSMUSP00000000724","abundance":0.401,"rank":14198,"name":"Kat2b","annotation":"Histone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY, PLK4, RRP9/U3-55K and TBX5. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulatin [...] "},{"id":"ENSMUSP00000059636","abundance":0.401,"rank":14199,"name":"Ccdc96","annotation":"Coiled-coil domain-containing protein 96."},{"id":"ENSMUSP00000042188","abundance":0.401,"rank":14200,"name":"Tpcn1","annotation":"Two pore calcium channel protein 1; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal and endosomal membrane."},{"id":"ENSMUSP00000050979","abundance":0.4,"rank":14201,"name":"Man1c1","annotation":"alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family."},{"id":"ENSMUSP00000029510","abundance":0.4,"rank":14202,"name":"Chil6","annotation":"cDNA sequence BC051070; Belongs to the glycosyl hydrolase 18 family."},{"id":"ENSMUSP00000104172","abundance":0.4,"rank":14203,"name":"Zswim9","annotation":"Uncharacterized protein ZSWIM9."},{"id":"ENSMUSP00000118415","abundance":0.4,"rank":14204,"name":"Laptm5","annotation":"Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family."},{"id":"ENSMUSP00000110820","abundance":0.4,"rank":14205,"name":"Rhox4g","annotation":"Reproductive homeobox 4G."},{"id":"ENSMUSP00000094197","abundance":0.4,"rank":14206,"name":"Rhox4b","annotation":"Reproductive homeobox 4B."},{"id":"ENSMUSP00000110837","abundance":0.4,"rank":14207,"name":"Rhox4c","annotation":"Reproductive homeobox 4C."},{"id":"ENSMUSP00000110824","abundance":0.4,"rank":14208,"name":"Rhox4f","annotation":"Reproductive homeobox 4F."},{"id":"ENSMUSP00000003360","abundance":0.4,"rank":14209,"name":"Car11","annotation":"Carbonic anhydrase-related protein 11; Does not have a catalytic activity; Belongs to the alpha-carbonic anhydrase family."},{"id":"ENSMUSP00000099408","abundance":0.4,"rank":14210,"name":"Zfp385c","annotation":"Zinc finger protein 385C."},{"id":"ENSMUSP00000106010","abundance":0.4,"rank":14211,"name":"Lrp2bp","annotation":"LRP2-binding protein; May act as an adapter that regulates LRP2 function."},{"id":"ENSMUSP00000093911","abundance":0.4,"rank":14212,"name":"Vwa5b2","annotation":"Von Willebrand factor A domain-containing protein 5B2."},{"id":"ENSMUSP00000156443","abundance":0.399,"rank":14213,"name":"Zfp983","annotation":"Zinc finger protein 983."},{"id":"ENSMUSP00000103690","abundance":0.399,"rank":14214,"name":"Kif24","annotation":"Kinesin-like protein KIF24; Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppres [...] "},{"id":"ENSMUSP00000091306","abundance":0.399,"rank":14215,"name":"Cep63","annotation":"Centrosomal protein of 63 kDa; Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and in delay mitotic progression. Belongs to the CEP63 family."},{"id":"ENSMUSP00000050496","abundance":0.399,"rank":14216,"name":"Sgsm2","annotation":"Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation ; Belongs to the RUTBC family."},{"id":"ENSMUSP00000102369","abundance":0.399,"rank":14217,"name":"Cyb5rl","annotation":"NADH-cytochrome b5 reductase-like; NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction. Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family."},{"id":"ENSMUSP00000110848","abundance":0.399,"rank":14218,"name":"Rhox4a","annotation":"Reproductive homeobox on X chromosome 4."},{"id":"ENSMUSP00000136542","abundance":0.399,"rank":14219,"name":"Rhox4a2","annotation":"Reproductive homeobox 4A2."},{"id":"ENSMUSP00000110829","abundance":0.399,"rank":14220,"name":"Rhox4d","annotation":"Reproductive homeobox 4D."},{"id":"ENSMUSP00000086475","abundance":0.399,"rank":14221,"name":"Rhox4e","annotation":"Reproductive homeobox 4E."},{"id":"ENSMUSP00000130527","abundance":0.399,"rank":14222,"name":"Xpo6","annotation":"Exportin-6; Mediates the nuclear export of actin and profilin-actin complexes in somatic cells; Belongs to the exportin family."},{"id":"ENSMUSP00000149216","abundance":0.399,"rank":14223,"name":"Olfr1513","annotation":"Olfactory receptor 1513."},{"id":"ENSMUSP00000070549","abundance":0.399,"rank":14224,"name":"Spats2","annotation":"Spermatogenesis-associated serine-rich protein 2; Belongs to the SPATS2 family."},{"id":"ENSMUSP00000116176","abundance":0.399,"rank":14225,"name":"Sertad4","annotation":"SERTA domain-containing protein 4."},{"id":"ENSMUSP00000129738","abundance":0.399,"rank":14226,"name":"Cenpf","annotation":"Centromere protein F."},{"id":"ENSMUSP00000067640","abundance":0.399,"rank":14227,"name":"Tas2r129","annotation":"Taste receptor type 2 member 129; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000036505","abundance":0.398,"rank":14228,"name":"Fbxw4","annotation":"F-box/WD repeat-containing protein 4; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling."},{"id":"ENSMUSP00000038779","abundance":0.398,"rank":14229,"name":"Nepro","annotation":"Nucleolus and neural progenitor protein; May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development. Belongs to the nepro family."},{"id":"ENSMUSP00000137837","abundance":0.398,"rank":14230,"name":"Crtam","annotation":"Cytotoxic and regulatory T-cell molecule; Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo; Belongs to the nectin family."},{"id":"ENSMUSP00000116797","abundance":0.398,"rank":14231,"name":"Nhej1","annotation":"Non-homologous end-joining factor 1; DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary. Binds DNA in a length-dependent manne [...] "},{"id":"ENSMUSP00000082965","abundance":0.398,"rank":14232,"name":"Sipa1l3","annotation":"Signal-induced proliferation-associated 1-like protein 3; Plays a critical role in epithelial cell morphogenesis, polarity, adhesion and cytoskeletal organization in the lens."},{"id":"ENSMUSP00000021029","abundance":0.397,"rank":14233,"name":"Efcab3","annotation":"EF-hand calcium-binding domain-containing protein 3."},{"id":"ENSMUSP00000023602","abundance":0.396,"rank":14234,"name":"Prl2a1","annotation":"Prolactin-2A1; Belongs to the somatotropin/prolactin family."},{"id":"ENSMUSP00000028299","abundance":0.396,"rank":14235,"name":"1700019N19Rik","annotation":"Uncharacterized protein C10orf82 homolog."},{"id":"ENSMUSP00000041809","abundance":0.396,"rank":14236,"name":"Bcdin3d","annotation":"RNA 5'-monophosphate methyltransferase; O-methyltransferase that specifically monomethylates 5'- monophosphate of cytoplasmic histidyl tRNA, acting as a capping enzyme. Less efficiently, also methylates the 5' monophosphate of pre-miRNAs, acting as a negative regulator of miRNA processing. The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1. Able to mediate methylation of pre- miR-145, as well as other pre-miRNAs. There is some controversy about the methylation  [...] "},{"id":"ENSMUSP00000041202","abundance":0.396,"rank":14237,"name":"Edem2","annotation":"ER degradation-enhancing alpha-mannosidase-like protein 2; Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner. May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (By similarity). Seems to recognize and bind to exposed hydrophobic regions in target proteins ; Belongs to the glycosyl hydrolase 47 family."},{"id":"ENSMUSP00000103497","abundance":0.395,"rank":14238,"name":"Tmem8b","annotation":"Transmembrane protein 8B; May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity); Belongs to the TMEM8 family."},{"id":"ENSMUSP00000153901","abundance":0.395,"rank":14239,"name":"Klf12","annotation":"Krueppel-like factor 12; Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter."},{"id":"ENSMUSP00000114088","abundance":0.395,"rank":14240,"name":"Ccdc9","annotation":"Coiled-coil domain-containing protein 9."},{"id":"ENSMUSP00000057449","abundance":0.395,"rank":14241,"name":"Trhde","annotation":"Thyrotropin-releasing hormone-degrading ectoenzyme; Specific inactivation of TRH after its release."},{"id":"ENSMUSP00000136946","abundance":0.395,"rank":14242,"name":"Rita1","annotation":"RBPJ-interacting and tubulin-associated protein 1; Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis (By similarity)."},{"id":"ENSMUSP00000125471","abundance":0.395,"rank":14243,"name":"Tex47","annotation":"Testis-expressed protein 47."},{"id":"ENSMUSP00000105569","abundance":0.395,"rank":14244,"name":"Mtmr3","annotation":"Myotubularin-related protein 3; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3- phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily."},{"id":"ENSMUSP00000061828","abundance":0.394,"rank":14245,"name":"Lrtm1","annotation":"Leucine-rich repeat and transmembrane domain-containing protein 1."},{"id":"ENSMUSP00000081221","abundance":0.394,"rank":14246,"name":"Plekhm2","annotation":"Pleckstrin homology domain-containing family M member 2; May play a role in the regulation of conventional kinesin activity. Required for maintenance of the Golgi apparatus organization. May play a role in membrane tubulation. May play a role in lysosomes movement and localization at the cell periphery."},{"id":"ENSMUSP00000032335","abundance":0.394,"rank":14247,"name":"Atf7ip","annotation":"Activating transcription factor 7-interacting protein 1; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversio [...] "},{"id":"ENSMUSP00000066582","abundance":0.394,"rank":14248,"name":"B3gat2","annotation":"Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2; Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins; Belongs to the glycosyltransferase 43 family."},{"id":"ENSMUSP00000132673","abundance":0.394,"rank":14249,"name":"Dis3l2","annotation":"DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] "},{"id":"ENSMUSP00000094662","abundance":0.394,"rank":14250,"name":"BC061237","annotation":"cDNA sequence BC061237."},{"id":"ENSMUSP00000057340","abundance":0.394,"rank":14251,"name":"Neto1","annotation":"Neuropilin and tolloid-like protein 1; Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A- containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory."},{"id":"ENSMUSP00000100594","abundance":0.394,"rank":14252,"name":"Psapl1","annotation":"Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids."},{"id":"ENSMUSP00000056420","abundance":0.394,"rank":14253,"name":"Pcdhb10","annotation":"Protocadherin beta 10."},{"id":"ENSMUSP00000134339","abundance":0.394,"rank":14254,"name":"Gm19684","annotation":"Predicted gene, 19684."},{"id":"ENSMUSP00000054275","abundance":0.394,"rank":14255,"name":"Lrp1b","annotation":"Low-density lipoprotein receptor-related protein 1B; Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis; Belongs to the LDLR family."},{"id":"ENSMUSP00000021307","abundance":0.393,"rank":14256,"name":"Ccdc103","annotation":"Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility."},{"id":"ENSMUSP00000027337","abundance":0.393,"rank":14257,"name":"Fam135a","annotation":"Protein FAM135A."},{"id":"ENSMUSP00000104872","abundance":0.393,"rank":14258,"name":"Sulf2","annotation":"Extracellular sulfatase Sulf-2; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin (By similarity); Belongs to the sulfatase family."},{"id":"ENSMUSP00000059668","abundance":0.393,"rank":14259,"name":"Prss50","annotation":"Probable threonine protease PRSS50; May be involved in proteolysis through its threonine endopeptidase activity; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000069114","abundance":0.393,"rank":14260,"name":"Ackr3","annotation":"Atypical chemokine receptor 3; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein- mediated signal transduction but instead induces beta-arrestin recruitment, lead [...] "},{"id":"ENSMUSP00000061834","abundance":0.393,"rank":14261,"name":"9930012K11Rik","annotation":"Uncharacterized protein C8orf58 homolog."},{"id":"ENSMUSP00000021097","abundance":0.393,"rank":14262,"name":"Recql5","annotation":"ATP-dependent DNA helicase Q5; DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination (By similarity). Belongs to the helica [...] "},{"id":"ENSMUSP00000105308","abundance":0.393,"rank":14263,"name":"Neto2","annotation":"Neuropilin and tolloid-like protein 2; Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity)."},{"id":"ENSMUSP00000117177","abundance":0.393,"rank":14264,"name":"Gm5724","annotation":"Solute carrier organic anion transporter family member."},{"id":"ENSMUSP00000011262","abundance":0.393,"rank":14265,"name":"Panx3","annotation":"Pannexin-3; Structural component of the gap junctions and the hemichannels; Belongs to the pannexin family."},{"id":"ENSMUSP00000037238","abundance":0.393,"rank":14266,"name":"Rilp","annotation":"Rab-interacting lysosomal protein; Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes."},{"id":"ENSMUSP00000000619","abundance":0.393,"rank":14267,"name":"Clcn4","annotation":"H(+)/Cl(-) exchange transporter 4; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (By similarity). Belongs to the chloride channel (TC 2.A.49) family. ClC- 4/CLCN4 subfamily."},{"id":"ENSMUSP00000121317","abundance":0.393,"rank":14268,"name":"Cnnm4","annotation":"Metal transporter CNNM4; Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function."},{"id":"ENSMUSP00000150556","abundance":0.393,"rank":14269,"name":"Olfr1320","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000095747","abundance":0.393,"rank":14270,"name":"Nfx1","annotation":"Transcriptional repressor NF-X1; Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2- dependent ubiquitination."},{"id":"ENSMUSP00000048714","abundance":0.392,"rank":14271,"name":"Dnajc16","annotation":"DnaJ homolog subfamily C member 16."},{"id":"ENSMUSP00000033415","abundance":0.392,"rank":14272,"name":"Nadsyn1","annotation":"Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source."},{"id":"ENSMUSP00000096972","abundance":0.392,"rank":14273,"name":"Cnnm2","annotation":"Metal transporter CNNM2; Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+); Belongs to the ACDP family."},{"id":"ENSMUSP00000066324","abundance":0.392,"rank":14274,"name":"Rnf103","annotation":"E3 ubiquitin-protein ligase RNF103; Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway."},{"id":"ENSMUSP00000029652","abundance":0.392,"rank":14275,"name":"Pdgfc","annotation":"Platelet-derived growth factor C, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in [...] "},{"id":"ENSMUSP00000043462","abundance":0.392,"rank":14276,"name":"Asb6","annotation":"Ankyrin repeat and SOCS box protein 6; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family."},{"id":"ENSMUSP00000117644","abundance":0.392,"rank":14277,"name":"Gm12258","annotation":"Predicted gene 12258."},{"id":"ENSMUSP00000077428","abundance":0.392,"rank":14278,"name":"Slc22a16","annotation":"Solute carrier family 22 member 16; High affinity carnitine transporter; the uptake is partially sodium-ion dependent. Thought to mediate the L-carnitine secretion mechanism from testis epididymal epithelium into the lumen which is involved in the maturation of spermatozoa. Also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. The uptake of TEA is inhibited by various organic cations. The uptake of doxorubicin is sodium-independent (By similarity)."},{"id":"ENSMUSP00000086333","abundance":0.392,"rank":14279,"name":"Tmem181a","annotation":"Transmembrane protein 181A."},{"id":"ENSMUSP00000095441","abundance":0.391,"rank":14280,"name":"Otud3","annotation":"OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity)."},{"id":"ENSMUSP00000149156","abundance":0.391,"rank":14281,"name":"Dock6","annotation":"Dedicator of cytokinesis protein 6; Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases (By similarity). Through its activation of CDC42 and RAC1, regulates neurite outgrowth in an vitro differentiation system."},{"id":"ENSMUSP00000152066","abundance":0.391,"rank":14282,"name":"Omd","annotation":"Osteomodulin; May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta(3)-integrin (By similarity)."},{"id":"ENSMUSP00000147475","abundance":0.391,"rank":14283,"name":"Zfp541","annotation":"Zinc finger protein 541; Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis."},{"id":"ENSMUSP00000124635","abundance":0.39,"rank":14284,"name":"Glis3","annotation":"Zinc finger protein GLIS3; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'."},{"id":"ENSMUSP00000098149","abundance":0.39,"rank":14285,"name":"Hhla1","annotation":"HERV-H LTR-associating protein 1 homolog."},{"id":"ENSMUSP00000150391","abundance":0.39,"rank":14286,"name":"Olfr308","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000075416","abundance":0.39,"rank":14287,"name":"Cntnap5c","annotation":"Contactin-associated protein like 5-3; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication; Belongs to the neurexin family."},{"id":"ENSMUSP00000061243","abundance":0.39,"rank":14288,"name":"Gpr4","annotation":"G-protein coupled receptor 4; Proton-sensing receptor coupled to several G-proteins, including G(s), G(13) and G(q)/G(11) proteins, leading to cAMP production."},{"id":"ENSMUSP00000142307","abundance":0.389,"rank":14289,"name":"Tmem131","annotation":"Transmembrane protein 131; May play a role in the immune response to viral infection; Belongs to the TMEM131 family."},{"id":"ENSMUSP00000070382","abundance":0.389,"rank":14290,"name":"Togaram1","annotation":"TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4. Belongs to the Crescerin family."},{"id":"ENSMUSP00000094809","abundance":0.389,"rank":14291,"name":"Gm5592","annotation":"Uncharacterized protein C2orf78 homolog."},{"id":"ENSMUSP00000020062","abundance":0.389,"rank":14292,"name":"Gprc6a","annotation":"G-protein coupled receptor family C group 6 member A; Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, diva [...] "},{"id":"ENSMUSP00000109244","abundance":0.389,"rank":14293,"name":"Adgrf2","annotation":"Adhesion G-protein coupled receptor F2; Orphan receptor; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily."},{"id":"ENSMUSP00000114522","abundance":0.389,"rank":14294,"name":"Ahnak2","annotation":"AHNAK nucleoprotein 2."},{"id":"ENSMUSP00000026474","abundance":0.389,"rank":14295,"name":"Gli1","annotation":"Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling; Belongs to the GLI C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000128497","abundance":0.389,"rank":14296,"name":"Ppp1r15a","annotation":"Protein phosphatase 1 regulatory subunit 15A; Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. In case of infection with vesicular stomatitis virus (VSV), impairs viral replication. Belongs to the PPP1R15 family."},{"id":"ENSMUSP00000004281","abundance":0.389,"rank":14297,"name":"Dyrk2","annotation":"Dual specificity tyrosine-phosphorylation-regulated kinase 2; Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosp [...] "},{"id":"ENSMUSP00000111184","abundance":0.389,"rank":14298,"name":"Eef1akmt4","annotation":"EEF1A lysine methyltransferase 4; Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2)."},{"id":"ENSMUSP00000051664","abundance":0.388,"rank":14299,"name":"Zc2hc1c","annotation":"Zinc finger C2HC domain-containing protein 1C; Belongs to the ZC2HC1 family."},{"id":"ENSMUSP00000001112","abundance":0.388,"rank":14300,"name":"Grk4","annotation":"G protein-coupled receptor kinase 4; Specifically phosphorylates the activated forms of G protein- coupled receptors; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily."},{"id":"ENSMUSP00000141545","abundance":0.388,"rank":14301,"name":"Gm21425","annotation":"Predicted gene, 21425."},{"id":"ENSMUSP00000142165","abundance":0.388,"rank":14302,"name":"Gm20773","annotation":"Predicted gene, 20773."},{"id":"ENSMUSP00000141432","abundance":0.388,"rank":14303,"name":"Gm21440","annotation":"Predicted gene, 21440."},{"id":"ENSMUSP00000139580","abundance":0.388,"rank":14304,"name":"Gm21310","annotation":"Predicted gene, 21310."},{"id":"ENSMUSP00000139409","abundance":0.388,"rank":14305,"name":"Gm21854","annotation":"Predicted gene, 21854."},{"id":"ENSMUSP00000139604","abundance":0.388,"rank":14306,"name":"Gm20737","annotation":"Predicted gene, 20737."},{"id":"ENSMUSP00000139666","abundance":0.388,"rank":14307,"name":"Gm20795","annotation":"Predicted gene, 20795."},{"id":"ENSMUSP00000142081","abundance":0.388,"rank":14308,"name":"Gm20831","annotation":"Predicted gene, 20831."},{"id":"ENSMUSP00000139540","abundance":0.388,"rank":14309,"name":"Gm20772","annotation":"Predicted gene, 20737."},{"id":"ENSMUSP00000140872","abundance":0.388,"rank":14310,"name":"Gm20777","annotation":"Predicted gene, 20777."},{"id":"ENSMUSP00000141810","abundance":0.388,"rank":14311,"name":"Gm21454","annotation":"Predicted gene, 21454."},{"id":"ENSMUSP00000139883","abundance":0.388,"rank":14312,"name":"Ssty1","annotation":"Y-linked testis-specific protein 1; Belongs to the SPIN/STSY family."},{"id":"ENSMUSP00000112602","abundance":0.388,"rank":14313,"name":"Cep135","annotation":"Centrosomal protein of 135 kDa; Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner  [...] "},{"id":"ENSMUSP00000024717","abundance":0.388,"rank":14314,"name":"Tbc1d5","annotation":"TBC1 domain family member 5; May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming ves [...] "},{"id":"ENSMUSP00000091771","abundance":0.388,"rank":14315,"name":"Slc17a9","annotation":"Solute carrier family 17 member 9; Involved in vesicular storage and exocytosis of ATP. May accumulate ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles (By similarity)."},{"id":"ENSMUSP00000118207","abundance":0.387,"rank":14316,"name":"Ndst3","annotation":"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has high deacetylase activity but low sulfotransferase activity."},{"id":"ENSMUSP00000138212","abundance":0.387,"rank":14317,"name":"Iqschfp","annotation":"IQCJ-SCHIP1 readthrough transcript protein; May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments. May also play a role in axon outgrowth and guidance."},{"id":"ENSMUSP00000047208","abundance":0.387,"rank":14318,"name":"Dcun1d2","annotation":"DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity)."},{"id":"ENSMUSP00000033846","abundance":0.387,"rank":14319,"name":"Angpt2","annotation":"Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity)."},{"id":"ENSMUSP00000091664","abundance":0.387,"rank":14320,"name":"Zscan25","annotation":"Zinc finger and SCAN domain-containing 25."},{"id":"ENSMUSP00000156910","abundance":0.387,"rank":14321,"name":"Gpr108","annotation":"Protein GPR108; Belongs to the LU7TM family."},{"id":"ENSMUSP00000135853","abundance":0.387,"rank":14322,"name":"Zbtb25","annotation":"Zinc finger and BTB domain-containing 25."},{"id":"ENSMUSP00000139017","abundance":0.386,"rank":14323,"name":"Trps1","annotation":"Zinc finger transcription factor Trps1; Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes."},{"id":"ENSMUSP00000124871","abundance":0.386,"rank":14324,"name":"Rc3h1","annotation":"Roquin-1; Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF, TNFRSF4 and in many more mRNAs. Cleaves translationally inactive mRNAs harboring a stem-loop (SL), often located in their 3'-UTRs, during the early phase of inflammation in a helicase UPF1-independent manner. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and  [...] "},{"id":"ENSMUSP00000018716","abundance":0.386,"rank":14325,"name":"Phf23","annotation":"PHD finger protein 23; Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria."},{"id":"ENSMUSP00000047627","abundance":0.386,"rank":14326,"name":"Trim69","annotation":"E3 ubiquitin-protein ligase TRIM69; May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000147931","abundance":0.385,"rank":14327,"name":"Olfr17","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000043996","abundance":0.385,"rank":14328,"name":"Ap1g2","annotation":"AP-1 complex subunit gamma-like 2; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV); Belongs to the adaptor complexes large subunit family."},{"id":"ENSMUSP00000023220","abundance":0.385,"rank":14329,"name":"Slc52a2","annotation":"Solute carrier family 52, riboflavin transporter, member 2; Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4- hydroxybutyrate."},{"id":"ENSMUSP00000028855","abundance":0.385,"rank":14330,"name":"Prom2","annotation":"Prominin-2."},{"id":"ENSMUSP00000040548","abundance":0.385,"rank":14331,"name":"Kcnh3","annotation":"Potassium voltage-gated channel subfamily H member 3; Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current with fast inactivation. Channel properties may be modulated by cAMP and subunit assembly."},{"id":"ENSMUSP00000097026","abundance":0.385,"rank":14332,"name":"Hpse2","annotation":"Inactive heparanase-2; Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro) (By similarity)."},{"id":"ENSMUSP00000154450","abundance":0.385,"rank":14333,"name":"Vmn1r6","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000141704","abundance":0.384,"rank":14334,"name":"Pcdhga7","annotation":"Protocadherin gamma subfamily A, 7."},{"id":"ENSMUSP00000025208","abundance":0.384,"rank":14335,"name":"Dnajc18","annotation":"DnaJ homolog subfamily C member 18."},{"id":"ENSMUSP00000015137","abundance":0.384,"rank":14336,"name":"Limk1","annotation":"LIM domain kinase 1; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In [...] "},{"id":"ENSMUSP00000059554","abundance":0.383,"rank":14337,"name":"Zfp943","annotation":"Zinc finger prtoein 943."},{"id":"ENSMUSP00000078814","abundance":0.383,"rank":14338,"name":"Olfr171","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149013","abundance":0.383,"rank":14339,"name":"Olfr446","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000145267","abundance":0.383,"rank":14340,"name":"Gpr162","annotation":"Probable G-protein coupled receptor 162; Orphan receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000140624","abundance":0.383,"rank":14341,"name":"Rgs1","annotation":"Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (By similarity)."},{"id":"ENSMUSP00000119136","abundance":0.383,"rank":14342,"name":"Cenpo","annotation":"Centromere protein O; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Modulates the kinetochore-bound levels of NDC80 complex (By similarity). Belongs to the CENP-O/MCM21 family."},{"id":"ENSMUSP00000075037","abundance":0.383,"rank":14343,"name":"Pstk","annotation":"L-seryl-tRNA(Sec) kinase; Specifically phosphorylates seryl-tRNA(Sec) to O- phosphoseryl-tRNA(Sec), an activated intermediate for selenocysteine biosynthesis. No activity with other tRNAs has been detected."},{"id":"ENSMUSP00000096874","abundance":0.383,"rank":14344,"name":"Nanos1","annotation":"Nanos homolog 1; May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion (By similarity). Not essential for normal development."},{"id":"ENSMUSP00000151158","abundance":0.382,"rank":14345,"name":"Olfr347","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000038655","abundance":0.382,"rank":14346,"name":"Prr32","annotation":"Proline-rich protein 32."},{"id":"ENSMUSP00000052904","abundance":0.382,"rank":14347,"name":"Epm2aip1","annotation":"EPM2A-interacting protein 1."},{"id":"ENSMUSP00000094093","abundance":0.382,"rank":14348,"name":"Scrt1","annotation":"Transcriptional repressor scratch 1; Transcriptional repressor that binds E-box motif CAGGTG (By similarity). Appears to function downstream of proneural bHLH proteins in promoting neural differentiation."},{"id":"ENSMUSP00000025295","abundance":0.382,"rank":14349,"name":"Spry4","annotation":"Protein sprouty homolog 4; Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras- dependent, activation of RAF1 (By similarity)."},{"id":"ENSMUSP00000124673","abundance":0.382,"rank":14350,"name":"Sh2d6","annotation":"SH2 domain-containing protein 6."},{"id":"ENSMUSP00000036053","abundance":0.382,"rank":14351,"name":"Trim46","annotation":"Tripartite motif-containing protein 46; Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon formation, the establishment of neuronal polarity and proper neuronal migration."},{"id":"ENSMUSP00000149403","abundance":0.381,"rank":14352,"name":"Olfr1122","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000033806","abundance":0.381,"rank":14353,"name":"Vsig1","annotation":"V-set and immunoglobulin domain-containing protein 1."},{"id":"ENSMUSP00000044725","abundance":0.381,"rank":14354,"name":"Bag4","annotation":"BAG family molecular chaperone regulator 4; Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Prevents constitutive TNFRSF1A signaling (By similarity). Negative regulator of PRKN translocation to damaged mitochondria (By similarity)."},{"id":"ENSMUSP00000028410","abundance":0.381,"rank":14355,"name":"Xirp2","annotation":"Xin actin-binding repeat-containing protein 2; Protects actin filaments from depolymerization."},{"id":"ENSMUSP00000139870","abundance":0.381,"rank":14356,"name":"Gm20736","annotation":"Predicted gene, 20736."},{"id":"ENSMUSP00000139688","abundance":0.381,"rank":14357,"name":"Gm20837","annotation":"Predicted gene, 20837."},{"id":"ENSMUSP00000048190","abundance":0.381,"rank":14358,"name":"Metap1d","annotation":"Methionine aminopeptidase 1D, mitochondrial; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed."},{"id":"ENSMUSP00000142185","abundance":0.38,"rank":14359,"name":"Gm20807","annotation":"Predicted gene, 20807."},{"id":"ENSMUSP00000024594","abundance":0.38,"rank":14360,"name":"Agpat4","annotation":"1-acyl-sn-glycerol-3-phosphate acyltransferase delta; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA)."},{"id":"ENSMUSP00000068003","abundance":0.38,"rank":14361,"name":"Eef2kmt","annotation":"Protein-lysine N-methyltransferase EEF2KMT; Catalyzes the trimethylation of eukaryotic elongation factor 2 (EEF2) on 'Lys-525'; Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family."},{"id":"ENSMUSP00000041828","abundance":0.38,"rank":14362,"name":"Sorcs2","annotation":"VPS10 domain-containing receptor SorCS2; The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro). Plays a role in the regulation of dendritic spine density in hippocampus neurons. Required for normal neurite branching and extension in response to BDNF. Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation. ProNGF  [...] "},{"id":"ENSMUSP00000125207","abundance":0.38,"rank":14363,"name":"Lrrtm1","annotation":"Leucine-rich repeat transmembrane neuronal protein 1; Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level."},{"id":"ENSMUSP00000030407","abundance":0.38,"rank":14364,"name":"Mycl","annotation":"Protein L-Myc."},{"id":"ENSMUSP00000128276","abundance":0.38,"rank":14365,"name":"Muc5b","annotation":"Mucin 5, subtype B, tracheobronchial."},{"id":"ENSMUSP00000018313","abundance":0.38,"rank":14366,"name":"Mfng","annotation":"Beta-1,3-N-acetylglucosaminyltransferase manic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1."},{"id":"ENSMUSP00000056530","abundance":0.38,"rank":14367,"name":"Phlpp1","annotation":"PH domain leucine-rich repeat-containing protein phosphatase 1; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (By similarity). Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity). Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of trans [...] "},{"id":"ENSMUSP00000034457","abundance":0.38,"rank":14368,"name":"Urb2","annotation":"URB2 ribosome biogenesis 2 homolog (S. cerevisiae)."},{"id":"ENSMUSP00000053692","abundance":0.38,"rank":14369,"name":"Unc80","annotation":"Protein unc-80 homolog; Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN- dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium; Belongs to the unc-80 family."},{"id":"ENSMUSP00000104567","abundance":0.379,"rank":14370,"name":"Gm14325","annotation":"Predicted gene 14325."},{"id":"ENSMUSP00000101359","abundance":0.379,"rank":14371,"name":"Zfp992","annotation":"Zinc finger protein 992."},{"id":"ENSMUSP00000081167","abundance":0.379,"rank":14372,"name":"Zfp991","annotation":"Predicted gene, OTTMUSG00000010657."},{"id":"ENSMUSP00000059102","abundance":0.379,"rank":14373,"name":"Crebrf","annotation":"CREB3 regulatory factor; Acts as a negative regulator of the endoplasmic reticulum stress response or unfolded protein response (UPR). Represses the transcriptional activity of CREB3 during the UPR. Recruits CREB3 into nuclear foci (By similarity)."},{"id":"ENSMUSP00000109872","abundance":0.379,"rank":14374,"name":"Traf2","annotation":"TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels  [...] "},{"id":"ENSMUSP00000145356","abundance":0.379,"rank":14375,"name":"Olfr781","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149485","abundance":0.379,"rank":14376,"name":"Olfr799","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000157465","abundance":0.378,"rank":14377,"name":"Elovl3","annotation":"Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different [...] "},{"id":"ENSMUSP00000040477","abundance":0.378,"rank":14378,"name":"Fshr","annotation":"Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways."},{"id":"ENSMUSP00000084234","abundance":0.378,"rank":14379,"name":"Slc22a7","annotation":"Solute carrier family 22 member 7; Mediates sodium-independent multispecific organic anion transport. High affinity transport of glutarate and prostaglandin E2 in a sodium-independent manner. Mediates also the uptake of alpha- ketoglutarate, p-aminohippuric acid, methotrexate, ochratoxin A, valproate, allopurinol and bumetanide."},{"id":"ENSMUSP00000135414","abundance":0.378,"rank":14380,"name":"Zfp169","annotation":"Zinc finger protein 169."},{"id":"ENSMUSP00000130012","abundance":0.378,"rank":14381,"name":"Fan1","annotation":"Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flankin [...] "},{"id":"ENSMUSP00000150662","abundance":0.378,"rank":14382,"name":"Olfr824","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000034692","abundance":0.378,"rank":14383,"name":"Olfm2","annotation":"Noelin-2; Involved in transforming growth factor beta (TGF-beta)- induced smooth muscle differentiation (By similarity). TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (By similarity). Plays a role in AMPAR complex organization. Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SM [...] "},{"id":"ENSMUSP00000113270","abundance":0.378,"rank":14384,"name":"G2e3","annotation":"G2/M phase-specific E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). Required for prevention of apoptotic death in early embryogenesis."},{"id":"ENSMUSP00000136378","abundance":0.377,"rank":14385,"name":"Fmo6","annotation":"Dimethylaniline monooxygenase [N-oxide-forming]."},{"id":"ENSMUSP00000106625","abundance":0.377,"rank":14386,"name":"Tlr5","annotation":"Toll-like receptor 5; Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF- kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an impo [...] "},{"id":"ENSMUSP00000039500","abundance":0.377,"rank":14387,"name":"Mis12","annotation":"Protein MIS12 homolog; Part of the MIS12 complex which is required for normal chromosome alignment and segregation and for kinetochore formation during mitosis. Essential for proper kinetochore microtubule attachments."},{"id":"ENSMUSP00000118931","abundance":0.377,"rank":14388,"name":"Yjefn3","annotation":"YjeF N-terminal domain-containing protein 3; May play a role in spermiogenesis and oogenesis."},{"id":"ENSMUSP00000041047","abundance":0.377,"rank":14389,"name":"Pth2","annotation":"Tuberoinfundibular peptide of 39 residues; Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits."},{"id":"ENSMUSP00000031018","abundance":0.377,"rank":14390,"name":"Rbks","annotation":"Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway."},{"id":"ENSMUSP00000019697","abundance":0.376,"rank":14391,"name":"Haus5","annotation":"HAUS augmin-like complex subunit 5; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex; Belongs to the HAUS5 family."},{"id":"ENSMUSP00000099733","abundance":0.376,"rank":14392,"name":"Nfe2l2","annotation":"Nuclear factor erythroid 2-related factor 2; Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles. In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex. In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, hetero [...] "},{"id":"ENSMUSP00000113800","abundance":0.376,"rank":14393,"name":"Sel1l2","annotation":"Protein sel-1 homolog 2."},{"id":"ENSMUSP00000090102","abundance":0.376,"rank":14394,"name":"Slc16a5","annotation":"Monocarboxylate transporter 6; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity); Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family."},{"id":"ENSMUSP00000149325","abundance":0.376,"rank":14395,"name":"Olfr447","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000042742","abundance":0.376,"rank":14396,"name":"Slc22a23","annotation":"Solute carrier family 22 member 23; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family."},{"id":"ENSMUSP00000132180","abundance":0.376,"rank":14397,"name":"Cyp2j11","annotation":"Cytochrome P450, family 2, subfamily j, polypeptide 11; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000004505","abundance":0.376,"rank":14398,"name":"Npc1l1","annotation":"NPC1-like intracellular cholesterol transporter 1; Plays a major role in cholesterol homeostasis. Is critical for the uptake of both phytosterol and cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption (By similarity). The protein may have a function in the transport of multiple lipids and their homeostasis, and may play a critical role in regulating lipid metabolism. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation an [...] "},{"id":"ENSMUSP00000046774","abundance":0.376,"rank":14399,"name":"Dennd3","annotation":"DENN domain-containing protein 3; Guanine nucleotide exchange factor (GEF) activating Rab12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab12 into its active GTP-bound form. Regulates autophagy in response to starvation through Rab12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-554 and Ser-572, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards Rab12. Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the  [...] "},{"id":"ENSMUSP00000024749","abundance":0.375,"rank":14400,"name":"Polh","annotation":"DNA polymerase eta; DNA polymerase specifically involved in the DNA repair by translesion synthesis (TLS). Due to low processivity on both damaged and normal DNA, cooperates with the heterotetrameric (REV3L, REV7, POLD2 and POLD3) POLZ complex for complete bypass of DNA lesions. Inserts one or 2 nucleotide(s) opposite the lesion, the primer is further extended by the tetrameric POLZ complex. In the case of 1,2- intrastrand d(GpG)-cisplatin cross-link, inserts dCTP opposite the 3' guanine (By similarity). Particularly important for the repair of UV- induced pyrimidine dimers. Although i [...] "},{"id":"ENSMUSP00000056358","abundance":0.375,"rank":14401,"name":"Fbxw21","annotation":"F-box and WD-40 domain protein 21."},{"id":"ENSMUSP00000154429","abundance":0.375,"rank":14402,"name":"Vmn1r13","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000143424","abundance":0.375,"rank":14403,"name":"Hgf","annotation":"Hepatocyte growth factor alpha chain; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily."},{"id":"ENSMUSP00000038373","abundance":0.375,"rank":14404,"name":"Kdm1b","annotation":"Lysine-specific histone demethylase 1B; Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methy [...] "},{"id":"ENSMUSP00000023289","abundance":0.375,"rank":14405,"name":"Chkb","annotation":"Choline/ethanolamine kinase; Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis; Belongs to the choline/ethanolamine kinase family."},{"id":"ENSMUSP00000099366","abundance":0.375,"rank":14406,"name":"Plcd3","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow."},{"id":"ENSMUSP00000046595","abundance":0.375,"rank":14407,"name":"Eef2k","annotation":"Eukaryotic elongation factor 2 kinase; Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced."},{"id":"ENSMUSP00000093233","abundance":0.374,"rank":14408,"name":"Scel","annotation":"Sciellin; May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope (By similarity)."},{"id":"ENSMUSP00000020349","abundance":0.374,"rank":14409,"name":"Apc2","annotation":"Adenomatous polyposis coli protein 2; Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1. Belongs to the adenomatous polyposis coli (APC) family."},{"id":"ENSMUSP00000095320","abundance":0.374,"rank":14410,"name":"Plekhm3","annotation":"Pleckstrin homology domain-containing family M member 3; Involved in skeletal muscle differentiation. May act as a scaffold protein for AKT1 during muscle differentiation."},{"id":"ENSMUSP00000147817","abundance":0.373,"rank":14411,"name":"Gm45337","annotation":"Predicted gene 45337."},{"id":"ENSMUSP00000039668","abundance":0.373,"rank":14412,"name":"Tab3","annotation":"TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL-1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor (By similarity)."},{"id":"ENSMUSP00000150917","abundance":0.373,"rank":14413,"name":"Olfr169","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000076458","abundance":0.373,"rank":14414,"name":"Gtpbp6","annotation":"Putative GTP-binding protein 6."},{"id":"ENSMUSP00000125106","abundance":0.373,"rank":14415,"name":"A930017K11Rik","annotation":"RIKEN cDNA A930017K11 gene."},{"id":"ENSMUSP00000084949","abundance":0.373,"rank":14416,"name":"Zfp952","annotation":"Zinc finger protein 952."},{"id":"ENSMUSP00000045452","abundance":0.373,"rank":14417,"name":"Adgb","annotation":"Androglobin; Belongs to the peptidase C2 family."},{"id":"ENSMUSP00000078453","abundance":0.373,"rank":14418,"name":"Nap1l3","annotation":"Nucleosome assembly protein 1-like 3; Belongs to the nucleosome assembly protein (NAP) family."},{"id":"ENSMUSP00000040945","abundance":0.373,"rank":14419,"name":"Stag3","annotation":"Cohesin subunit SA-3; Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I; Belongs to the SCC3 family."},{"id":"ENSMUSP00000147726","abundance":0.373,"rank":14420,"name":"Frat1","annotation":"Proto-oncogene FRAT1; Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis."},{"id":"ENSMUSP00000006825","abundance":0.372,"rank":14421,"name":"Nphs1","annotation":"Nephrin; Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion."},{"id":"ENSMUSP00000124211","abundance":0.372,"rank":14422,"name":"Mettl11b","annotation":"Alpha N-terminal protein methyltransferase 1B; Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation (By similarity)."},{"id":"ENSMUSP00000011733","abundance":0.372,"rank":14423,"name":"Fsd1","annotation":"Fibronectin type III and SPRY domain-containing protein 1; May be involved in microtubule organization and stabilization."},{"id":"ENSMUSP00000049252","abundance":0.372,"rank":14424,"name":"Lpcat2","annotation":"Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium- dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2- acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, a [...] "},{"id":"ENSMUSP00000004453","abundance":0.372,"rank":14425,"name":"Gpx6","annotation":"Glutathione peroxidase 6; Belongs to the glutathione peroxidase family."},{"id":"ENSMUSP00000124068","abundance":0.372,"rank":14426,"name":"Pde8b","annotation":"High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland (By similarity)."},{"id":"ENSMUSP00000021791","abundance":0.372,"rank":14427,"name":"Gcm2","annotation":"Chorion-specific transcription factor GCMb; Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development."},{"id":"ENSMUSP00000038665","abundance":0.372,"rank":14428,"name":"Mettl25","annotation":"Methyltransferase-like protein 25; Putative methyltransferase."},{"id":"ENSMUSP00000058720","abundance":0.372,"rank":14429,"name":"4921504E06Rik","annotation":"RIKEN cDNA 4921504E06 gene."},{"id":"ENSMUSP00000099955","abundance":0.371,"rank":14430,"name":"Adamts13","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 13; Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation."},{"id":"ENSMUSP00000106145","abundance":0.371,"rank":14431,"name":"Hecw1","annotation":"E3 ubiquitin-protein ligase HECW1; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1."},{"id":"ENSMUSP00000044177","abundance":0.371,"rank":14432,"name":"Otoa","annotation":"Otoancorin; May act as an adhesion molecule. Belongs to the stereocilin family."},{"id":"ENSMUSP00000089298","abundance":0.371,"rank":14433,"name":"Hfe","annotation":"Hereditary hemochromatosis protein homolog; Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin."},{"id":"ENSMUSP00000053690","abundance":0.371,"rank":14434,"name":"Sh2d7","annotation":"SH2 domain-containing protein 7."},{"id":"ENSMUSP00000075483","abundance":0.371,"rank":14435,"name":"Tas2r125","annotation":"Taste receptor type 2 member 125; Putative taste receptor which may play a role in the perception of bitterness."},{"id":"ENSMUSP00000097515","abundance":0.371,"rank":14436,"name":"Sesn1","annotation":"Sestrin-1; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-med [...] "},{"id":"ENSMUSP00000100009","abundance":0.371,"rank":14437,"name":"Nxph2","annotation":"Neurexophilin-2; May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors. Belongs to the neurexophilin family."},{"id":"ENSMUSP00000031986","abundance":0.37,"rank":14438,"name":"Rab19","annotation":"Ras-related protein Rab-19; Belongs to the small GTPase superfamily. Rab family."},{"id":"ENSMUSP00000113768","abundance":0.37,"rank":14439,"name":"Ift88","annotation":"Intraflagellar transport protein 88 homolog; Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment."},{"id":"ENSMUSP00000057282","abundance":0.37,"rank":14440,"name":"Otud7a","annotation":"OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains."},{"id":"ENSMUSP00000094095","abundance":0.37,"rank":14441,"name":"Spin4","annotation":"Spindlin-4; Exhibits H3K4me3-binding activity. Belongs to the SPIN/STSY family."},{"id":"ENSMUSP00000109156","abundance":0.37,"rank":14442,"name":"Majin","annotation":"Membrane-anchored junction protein; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1- TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release [...] "},{"id":"ENSMUSP00000071829","abundance":0.37,"rank":14443,"name":"Kcnj14","annotation":"ATP-sensitive inward rectifier potassium channel 14; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium [...] "},{"id":"ENSMUSP00000099879","abundance":0.37,"rank":14444,"name":"Ranbp17","annotation":"Ran-binding protein 17; May function as a nuclear transport receptor; Belongs to the exportin family."},{"id":"ENSMUSP00000103454","abundance":0.37,"rank":14445,"name":"Zcchc7","annotation":"Zinc finger CCHC domain-containing protein 7."},{"id":"ENSMUSP00000071025","abundance":0.37,"rank":14446,"name":"Shisa6","annotation":"Protein shisa-6; Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway."},{"id":"ENSMUSP00000128710","abundance":0.369,"rank":14447,"name":"Taf5l","annotation":"TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L; Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (By similarity). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state."},{"id":"ENSMUSP00000113115","abundance":0.369,"rank":14448,"name":"Spock2","annotation":"Testican-2; May participate in diverse steps of neurogenesis. Binds calcium (By similarity)."},{"id":"ENSMUSP00000035392","abundance":0.369,"rank":14449,"name":"Slc25a43","annotation":"Solute carrier family 25 member 43."},{"id":"ENSMUSP00000140242","abundance":0.369,"rank":14450,"name":"Gm28102","annotation":"Predicted gene 28102."},{"id":"ENSMUSP00000141382","abundance":0.369,"rank":14451,"name":"Gm28870","annotation":"Predicted gene 28870."},{"id":"ENSMUSP00000141161","abundance":0.369,"rank":14452,"name":"Gm20911","annotation":"Predicted gene, 20911."},{"id":"ENSMUSP00000139858","abundance":0.369,"rank":14453,"name":"Gm20820","annotation":"Predicted gene 28870."},{"id":"ENSMUSP00000140952","abundance":0.369,"rank":14454,"name":"Gm20824","annotation":"Predicted gene, 20824."},{"id":"ENSMUSP00000101857","abundance":0.369,"rank":14455,"name":"Card14","annotation":"Caspase recruitment domain-containing protein 14; Acts as a scaffolding protein that can activate the inflammatory transcription factor NF-kappa-B and p38/JNK MAP kinase signaling pathways. Forms a signaling complex with BCL10 and MALT1, and activates MALT1 proteolytic activity and inflammatory gene expression. MALT1 is indispensable for CARD14-induced activation of NF-kappa-B and p38/JNK MAP kinases. May play a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis."},{"id":"ENSMUSP00000051554","abundance":0.369,"rank":14456,"name":"Fscb","annotation":"Fibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium."},{"id":"ENSMUSP00000048320","abundance":0.368,"rank":14457,"name":"Cc2d2a","annotation":"Coiled-coil and C2 domain-containing protein 2A; Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling."},{"id":"ENSMUSP00000046118","abundance":0.368,"rank":14458,"name":"B3galt2","annotation":"Beta-1,3-galactosyltransferase 2; Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Can also utilize substrates with a terminal galactose residue, albeit with lower efficiency. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins; Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000081260","abundance":0.368,"rank":14459,"name":"Zdhhc18","annotation":"Palmitoyltransferase ZDHHC18; Has palmitoyltransferase activity towards HRAS and LCK."},{"id":"ENSMUSP00000131409","abundance":0.368,"rank":14460,"name":"Neu2","annotation":"Sialidase-2; Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides; Belongs to the glycosyl hydrolase 33 family."},{"id":"ENSMUSP00000134739","abundance":0.368,"rank":14461,"name":"Cyhr1","annotation":"Cysteine and histidine-rich protein 1; Belongs to the CYHR1 family."},{"id":"ENSMUSP00000047213","abundance":0.368,"rank":14462,"name":"Lrrc52","annotation":"Leucine-rich repeat-containing protein 52; Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium (By similarity). KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties, shifting KCNU1 gating to more negative potentials at a given pH."},{"id":"ENSMUSP00000044363","abundance":0.368,"rank":14463,"name":"Recql4","annotation":"ATP-dependent DNA helicase Q4; DNA-dependent ATPase (By similarity). May play a role in development of the palate and the limbs. May modulate chromosome segregation."},{"id":"ENSMUSP00000040282","abundance":0.368,"rank":14464,"name":"Zfp715","annotation":"Zinc finger protein 715."},{"id":"ENSMUSP00000098975","abundance":0.367,"rank":14465,"name":"Npas3","annotation":"Neuronal PAS domain-containing protein 3; May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness."},{"id":"ENSMUSP00000096346","abundance":0.367,"rank":14466,"name":"Lrif1","annotation":"Ligand-dependent nuclear receptor-interacting factor 1; Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases."},{"id":"ENSMUSP00000142692","abundance":0.367,"rank":14467,"name":"Ccna1","annotation":"Cyclin-A1; May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells."},{"id":"ENSMUSP00000084054","abundance":0.367,"rank":14468,"name":"Asb1","annotation":"Ankyrin repeat and SOCS box protein 1; May play a role in testis development. Probable substrate- recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Belongs to the ankyrin SOCS box (ASB) family."},{"id":"ENSMUSP00000093117","abundance":0.367,"rank":14469,"name":"Odf3l2","annotation":"Outer dense fiber protein 3-like protein 2; Belongs to the ODF3 family."},{"id":"ENSMUSP00000020049","abundance":0.367,"rank":14470,"name":"Ccdc59","annotation":"Thyroid transcription factor 1-associated protein 26; Component of the transcription complexes of the pulmonary surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities (By similarity); Belongs to the TAP26 family."},{"id":"ENSMUSP00000153898","abundance":0.366,"rank":14471,"name":"Vmn1r30","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000136549","abundance":0.366,"rank":14472,"name":"Zfp616","annotation":"Zinc finger protein 616."},{"id":"ENSMUSP00000052607","abundance":0.366,"rank":14473,"name":"Wdfy3","annotation":"WD repeat and FYVE domain-containing protein 3; Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5- ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures) (By similarity). Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the [...] "},{"id":"ENSMUSP00000107494","abundance":0.366,"rank":14474,"name":"Gm5930","annotation":"Predicted gene 5930."},{"id":"ENSMUSP00000037657","abundance":0.366,"rank":14475,"name":"Parp14","annotation":"Protein mono-ADP-ribosyltransferase PARP14; ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Catalyzes mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggeste [...] "},{"id":"ENSMUSP00000023734","abundance":0.366,"rank":14476,"name":"Wnt1","annotation":"Proto-oncogene Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation (By similarity). In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis (By similarity)."},{"id":"ENSMUSP00000111391","abundance":0.366,"rank":14477,"name":"Cacna1f","annotation":"Voltage-dependent L-type calcium channel subunit alpha-1F; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines (B [...] "},{"id":"ENSMUSP00000038490","abundance":0.365,"rank":14478,"name":"Disp3","annotation":"Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol. Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells; Belongs to the patched family."},{"id":"ENSMUSP00000058801","abundance":0.365,"rank":14479,"name":"Pcdhb9","annotation":"Protocadherin beta 9."},{"id":"ENSMUSP00000093991","abundance":0.365,"rank":14480,"name":"Slc22a27","annotation":"Solute carrier family 22 member 27; [Isoform 1]: Does not appear to have transporter activity. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family."},{"id":"ENSMUSP00000112934","abundance":0.364,"rank":14481,"name":"Magi3","annotation":"Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the [...] "},{"id":"ENSMUSP00000094294","abundance":0.364,"rank":14482,"name":"Loxhd1","annotation":"Lipoxygenase homology domain-containing protein 1; Required for normal function of hair cells in the inner ear."},{"id":"ENSMUSP00000149257","abundance":0.364,"rank":14483,"name":"Olfr429","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000105379","abundance":0.364,"rank":14484,"name":"Bpifb4","annotation":"BPI fold-containing family B member 4; May have the capacity to recognize and bind specific classes of odorants. May act as a carrier molecule, transporting odorants across the mucus layer to access receptor sites. May serve as a primary defense mechanism by recognizing and removing potentially harmful odorants or pathogenic microorganisms from the mucosa or clearing excess odorant from mucus to enable new odorant stimuli to be received (By similarity)."},{"id":"ENSMUSP00000130851","abundance":0.364,"rank":14485,"name":"Cdh18","annotation":"Cadherin 18; Cadherins are calcium-dependent cell adhesion proteins."},{"id":"ENSMUSP00000134217","abundance":0.363,"rank":14486,"name":"Zfp266","annotation":"Zinc finger protein 266."},{"id":"ENSMUSP00000043130","abundance":0.363,"rank":14487,"name":"Bahd1","annotation":"Bromo adjacent homology domain-containing 1 protein; Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins (By similarity)."},{"id":"ENSMUSP00000080949","abundance":0.362,"rank":14488,"name":"Mdc1","annotation":"Mediator of DNA damage checkpoint protein 1; Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be ac [...] "},{"id":"ENSMUSP00000060771","abundance":0.362,"rank":14489,"name":"Rin3","annotation":"Ras and Rab interactor 3; Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function (By similarity)."},{"id":"ENSMUSP00000075566","abundance":0.362,"rank":14490,"name":"Abtb2","annotation":"Ankyrin repeat and BTB/POZ domain-containing protein 2; May be involved in the initiation of hepatocyte growth."},{"id":"ENSMUSP00000134564","abundance":0.362,"rank":14491,"name":"Actl9","annotation":"Actin-like protein 9."},{"id":"ENSMUSP00000080219","abundance":0.362,"rank":14492,"name":"Pbx4","annotation":"Pre-B-cell leukemia transcription factor 4; Belongs to the TALE/PBX homeobox family."},{"id":"ENSMUSP00000025815","abundance":0.362,"rank":14493,"name":"Cbwd1","annotation":"COBW domain-containing protein 1."},{"id":"ENSMUSP00000140625","abundance":0.362,"rank":14494,"name":"Zfp951","annotation":"Zinc finger protein 951."},{"id":"ENSMUSP00000081012","abundance":0.362,"rank":14495,"name":"Gpx2","annotation":"Glutathione peroxidase 2."},{"id":"ENSMUSP00000032107","abundance":0.362,"rank":14496,"name":"Kbtbd8","annotation":"Kelch repeat and BTB domain-containing protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification."},{"id":"ENSMUSP00000030443","abundance":0.362,"rank":14497,"name":"Ptch2","annotation":"Protein patched homolog 2; Plays a role in the control of cellular growth (By similarity). May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH); Belongs to the patched family."},{"id":"ENSMUSP00000110287","abundance":0.362,"rank":14498,"name":"Armc3","annotation":"Armadillo repeat-containing protein 3."},{"id":"ENSMUSP00000030339","abundance":0.361,"rank":14499,"name":"Tnfrsf8","annotation":"Tumor necrosis factor receptor superfamily member 8; Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa- B (By similarity)."},{"id":"ENSMUSP00000080480","abundance":0.361,"rank":14500,"name":"Cacul1","annotation":"CDK2-associated and cullin domain-containing protein 1; Cell cycle associated protein capable of promoting cell proliferation through the activation of CDK2 at the G1/S phase transition."},{"id":"ENSMUSP00000105847","abundance":0.361,"rank":14501,"name":"Spef1","annotation":"Sperm flagellar protein 1; Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock. Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity)."},{"id":"ENSMUSP00000035929","abundance":0.36,"rank":14502,"name":"Xrra1","annotation":"X-ray radiation resistance-associated protein 1; May be involved in the response of cells to X-ray radiation."},{"id":"ENSMUSP00000118125","abundance":0.36,"rank":14503,"name":"Rell1","annotation":"RELT-like protein 1; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed; Belongs to the RELT family."},{"id":"ENSMUSP00000061544","abundance":0.36,"rank":14504,"name":"Cilp2","annotation":"Cartilage intermediate layer protein 2 C1; May play a role in cartilage scaffolding."},{"id":"ENSMUSP00000103682","abundance":0.36,"rank":14505,"name":"Tbx4","annotation":"T-box transcription factor TBX4; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation."},{"id":"ENSMUSP00000085293","abundance":0.36,"rank":14506,"name":"S1pr3","annotation":"Sphingosine 1-phosphate receptor 3; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues."},{"id":"ENSMUSP00000151961","abundance":0.36,"rank":14507,"name":"Baz2a","annotation":"Bromodomain adjacent to zinc finger domain protein 2A; Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H [...] "},{"id":"ENSMUSP00000114062","abundance":0.36,"rank":14508,"name":"Qser1","annotation":"Glutamine and serine-rich 1."},{"id":"ENSMUSP00000084427","abundance":0.36,"rank":14509,"name":"Dcun1d4","annotation":"DCN1-like protein 4."},{"id":"ENSMUSP00000135959","abundance":0.36,"rank":14510,"name":"Mgat4c","annotation":"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity) (By similarity)."},{"id":"ENSMUSP00000090789","abundance":0.36,"rank":14511,"name":"Taf1c","annotation":"TATA box-binding protein-associated factor RNA polymerase I subunit C; Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via [...] "},{"id":"ENSMUSP00000115383","abundance":0.359,"rank":14512,"name":"Gm13941","annotation":"Predicted gene 13941."},{"id":"ENSMUSP00000150637","abundance":0.359,"rank":14513,"name":"Olfr1029","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000079522","abundance":0.359,"rank":14514,"name":"Olfr1028","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000026710","abundance":0.359,"rank":14515,"name":"Usp16","annotation":"Ubiquitin carboxyl-terminal hydrolase 16; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiqu [...] "},{"id":"ENSMUSP00000034093","abundance":0.359,"rank":14516,"name":"Eif2ak3","annotation":"Eukaryotic translation initiation factor 2-alpha kinase 3; Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2- alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated [...] "},{"id":"ENSMUSP00000096436","abundance":0.358,"rank":14517,"name":"Foxr1","annotation":"Forkhead box protein R1."},{"id":"ENSMUSP00000125167","abundance":0.358,"rank":14518,"name":"Tcf19","annotation":"Transcription factor 19-like protein."},{"id":"ENSMUSP00000045570","abundance":0.358,"rank":14519,"name":"Zbtb41","annotation":"Zinc finger and BTB domain-containing protein 41; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000034429","abundance":0.358,"rank":14520,"name":"Tmem231","annotation":"Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling; Belongs to the TMEM231 family."},{"id":"ENSMUSP00000029905","abundance":0.357,"rank":14521,"name":"Cyp7a1","annotation":"Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of [...] "},{"id":"ENSMUSP00000087009","abundance":0.357,"rank":14522,"name":"Pced1a","annotation":"PC-esterase domain-containing protein 1A; Belongs to the PC-esterase family."},{"id":"ENSMUSP00000047261","abundance":0.357,"rank":14523,"name":"Mmp1b","annotation":"Interstitial collagenase B; Belongs to the peptidase M10A family."},{"id":"ENSMUSP00000031262","abundance":0.357,"rank":14524,"name":"Coq2","annotation":"4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate."},{"id":"ENSMUSP00000130121","abundance":0.357,"rank":14525,"name":"D630045J12Rik","annotation":"UPF0606 protein KIAA1549; Belongs to the UPF0606 family."},{"id":"ENSMUSP00000127387","abundance":0.357,"rank":14526,"name":"Mier2","annotation":"Mesoderm induction early response protein 2; Transcriptional repressor."},{"id":"ENSMUSP00000060768","abundance":0.357,"rank":14527,"name":"Kbtbd7","annotation":"Kelch repeat and BTB (POZ) domain-containing 7."},{"id":"ENSMUSP00000029061","abundance":0.357,"rank":14528,"name":"Sall4","annotation":"Sal-like protein 4; Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells; Belongs to the sal C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000153036","abundance":0.357,"rank":14529,"name":"Ndst2","annotation":"Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2; Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)."},{"id":"ENSMUSP00000049686","abundance":0.357,"rank":14530,"name":"Lrrc25","annotation":"Leucine-rich repeat-containing protein 25; Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy. Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA."},{"id":"ENSMUSP00000056744","abundance":0.357,"rank":14531,"name":"Sfmbt1","annotation":"Scm-like with four MBT domains protein 1; Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis."},{"id":"ENSMUSP00000068828","abundance":0.357,"rank":14532,"name":"Pcdha1","annotation":"Protocadherin alpha 1."},{"id":"ENSMUSP00000056592","abundance":0.357,"rank":14533,"name":"Dnajb8","annotation":"DnaJ homolog subfamily B member 8; Efficient suppressor of aggregation and toxicity of disease- associated polyglutamine proteins."},{"id":"ENSMUSP00000145858","abundance":0.357,"rank":14534,"name":"Emsy","annotation":"BRCA2-interacting transcriptional repressor EMSY; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (By similarity). As part of a H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity)."},{"id":"ENSMUSP00000108318","abundance":0.357,"rank":14535,"name":"Zfp644","annotation":"Zinc finger protein 644."},{"id":"ENSMUSP00000116397","abundance":0.357,"rank":14536,"name":"Cd209g","annotation":"CD209g antigen."},{"id":"ENSMUSP00000048665","abundance":0.356,"rank":14537,"name":"1700028J19Rik","annotation":"RIKEN cDNA 1700028J19 gene."},{"id":"ENSMUSP00000032106","abundance":0.356,"rank":14538,"name":"1700003E16Rik","annotation":"Uncharacterized protein C2orf81 homolog."},{"id":"ENSMUSP00000070865","abundance":0.356,"rank":14539,"name":"Chat","annotation":"Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses; Belongs to the carnitine/choline acetyltransferase family."},{"id":"ENSMUSP00000080350","abundance":0.356,"rank":14540,"name":"Pramef6","annotation":"PRAME family member 6."},{"id":"ENSMUSP00000041243","abundance":0.356,"rank":14541,"name":"Ablim3","annotation":"Actin-binding LIM protein 3; May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity."},{"id":"ENSMUSP00000007790","abundance":0.356,"rank":14542,"name":"Rad51c","annotation":"DNA repair protein RAD51 homolog 3; Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Part of the RAD21 paralog protein complexes BCDX2 and CX3 which act at different stages of the BRCA1- BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 seems to act downstream of BRCA2 recruitment and upstream of RAD51 recruitment; CX3 seems to act downstream of RAD51 recruitment; both complexes bind predominantly to the int [...] "},{"id":"ENSMUSP00000089225","abundance":0.356,"rank":14543,"name":"Lrrtm2","annotation":"Leucine-rich repeat transmembrane neuronal protein 2; Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity)."},{"id":"ENSMUSP00000150451","abundance":0.356,"rank":14544,"name":"Olfr430","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000029485","abundance":0.356,"rank":14545,"name":"1700013F07Rik","annotation":"Protein C1orf194 homolog; May play an important role for the maintenance of myelin-axon integrity. May affect intracellular Ca(2+) homeostasis (By similarity)."},{"id":"ENSMUSP00000031121","abundance":0.355,"rank":14546,"name":"Gabra4","annotation":"Gamma-aminobutyric acid receptor subunit alpha-4; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel."},{"id":"ENSMUSP00000049527","abundance":0.355,"rank":14547,"name":"Taar1","annotation":"Trace amine-associated receptor 1; Receptor for trace amines, including beta-phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained spe [...] "},{"id":"ENSMUSP00000047374","abundance":0.355,"rank":14548,"name":"Ptpdc1","annotation":"Protein tyrosine phosphatase domain-containing protein 1; May play roles in cilia formation and/or maintenance."},{"id":"ENSMUSP00000042053","abundance":0.355,"rank":14549,"name":"Micall1","annotation":"MICAL-like protein 1; Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth."},{"id":"ENSMUSP00000036514","abundance":0.355,"rank":14550,"name":"Zfp472","annotation":"Zinc finger protein 472."},{"id":"ENSMUSP00000028802","abundance":0.355,"rank":14551,"name":"Knl1","annotation":"Kinetochore scaffold 1; Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Directly links spindle checkpoint proteins BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore (By similarity)."},{"id":"ENSMUSP00000125478","abundance":0.355,"rank":14552,"name":"Man2c1","annotation":"Alpha-mannosidase 2C1; Cleaves alpha 1,2-, alpha 1,3-, and alpha 1,6-linked mannose residues from glycoproteins. Involved in the degradation of free oligosaccharides in the cytoplasm."},{"id":"ENSMUSP00000054799","abundance":0.355,"rank":14553,"name":"Dsg1c","annotation":"Desmoglein-1-gamma; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion."},{"id":"ENSMUSP00000042416","abundance":0.354,"rank":14554,"name":"Tmem177","annotation":"Transmembrane protein 177; Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein."},{"id":"ENSMUSP00000040138","abundance":0.354,"rank":14555,"name":"Cox10","annotation":"Protoheme IX farnesyltransferase, mitochondrial; Converts protoheme IX and farnesyl diphosphate to heme O."},{"id":"ENSMUSP00000120568","abundance":0.354,"rank":14556,"name":"Optc","annotation":"Opticin; Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization. Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily."},{"id":"ENSMUSP00000072712","abundance":0.354,"rank":14557,"name":"Prl7c1","annotation":"Prolactin-7C1."},{"id":"ENSMUSP00000033099","abundance":0.354,"rank":14558,"name":"Fgf21","annotation":"Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family."},{"id":"ENSMUSP00000032338","abundance":0.354,"rank":14559,"name":"Gucy2c","annotation":"Heat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin (By similarity)."},{"id":"ENSMUSP00000099326","abundance":0.353,"rank":14560,"name":"Ush1g","annotation":"Usher syndrome type-1G protein homolog; Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing."},{"id":"ENSMUSP00000092459","abundance":0.353,"rank":14561,"name":"Vmn2r51","annotation":"Vomeronasal 2, receptor 51."},{"id":"ENSMUSP00000055485","abundance":0.353,"rank":14562,"name":"Pced1b","annotation":"PC-esterase domain-containing protein 1B; Belongs to the PC-esterase family."},{"id":"ENSMUSP00000127300","abundance":0.353,"rank":14563,"name":"Btbd9","annotation":"BTB/POZ domain-containing protein 9."},{"id":"ENSMUSP00000099716","abundance":0.352,"rank":14564,"name":"Foxo6","annotation":"Forkhead box protein O6; Transcriptional activator."},{"id":"ENSMUSP00000131401","abundance":0.352,"rank":14565,"name":"Sspo","annotation":"SCO-spondin; Involved in the modulation of neuronal aggregation. May be involved in developmental events during the formation of the central nervous system (By similarity); Belongs to the thrombospondin family."},{"id":"ENSMUSP00000033575","abundance":0.352,"rank":14566,"name":"Magee2","annotation":"Melanoma antigen, family E, 2."},{"id":"ENSMUSP00000103709","abundance":0.352,"rank":14567,"name":"4931406P16Rik","annotation":"RIKEN cDNA 4931406P16 gene."},{"id":"ENSMUSP00000064613","abundance":0.352,"rank":14568,"name":"Gm5072","annotation":"Predicted gene 5072."},{"id":"ENSMUSP00000098944","abundance":0.352,"rank":14569,"name":"Gm8914","annotation":"Predicted gene 8914."},{"id":"ENSMUSP00000025270","abundance":0.352,"rank":14570,"name":"Riok3","annotation":"Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7- mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of  [...] "},{"id":"ENSMUSP00000059433","abundance":0.351,"rank":14571,"name":"C2cd4c","annotation":"C2 calcium-dependent domain-containing protein 4C; Belongs to the C2CD4 family."},{"id":"ENSMUSP00000025053","abundance":0.351,"rank":14572,"name":"Mllt1","annotation":"Myeloid/lymphoid or mixed-lineage leukemia (Trithorax homolog, Drosophila) translocated to, 1."},{"id":"ENSMUSP00000092548","abundance":0.351,"rank":14573,"name":"Ccdc173","annotation":"Coiled-coil domain-containing protein 173."},{"id":"ENSMUSP00000043088","abundance":0.351,"rank":14574,"name":"Daglb","annotation":"Sn1-specific diacylglycerol lipase beta; Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity). Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000000291","abundance":0.351,"rank":14575,"name":"Mnt","annotation":"Max-binding protein MNT; Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'."},{"id":"ENSMUSP00000035092","abundance":0.351,"rank":14576,"name":"Myd88","annotation":"Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF- kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF- kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). Activates IRF1 resulting in it [...] "},{"id":"ENSMUSP00000034761","abundance":0.351,"rank":14577,"name":"Ice2","annotation":"Little elongation complex subunit 2; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III."},{"id":"ENSMUSP00000104132","abundance":0.351,"rank":14578,"name":"Hif3a","annotation":"Hypoxia-inducible factor 3-alpha; Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression. Plays a role in the development of the cardiorespiratory system. [Isoform 2]: Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia- inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. May ac [...] "},{"id":"ENSMUSP00000019069","abundance":0.351,"rank":14579,"name":"Heatr9","annotation":"Protein HEATR9."},{"id":"ENSMUSP00000053786","abundance":0.351,"rank":14580,"name":"Fbxw13","annotation":"F-box and WD-40 domain protein 13."},{"id":"ENSMUSP00000051453","abundance":0.351,"rank":14581,"name":"4930503B20Rik","annotation":"RIKEN cDNA 4930503B20 gene."},{"id":"ENSMUSP00000047126","abundance":0.351,"rank":14582,"name":"Nt5dc1","annotation":"5'-nucleotidase domain-containing protein 1."},{"id":"ENSMUSP00000050412","abundance":0.351,"rank":14583,"name":"S1pr4","annotation":"Sphingosine 1-phosphate receptor 4; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (By similarity)."},{"id":"ENSMUSP00000146093","abundance":0.35,"rank":14584,"name":"Gucy2d","annotation":"Guanylate cyclase D; Functions as an olfactory receptor activated by urine odorants, uroguanylin and guanylin and as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2). Has guanylate cyclase activity upon binding of the ligand (By similarity). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency. Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference."},{"id":"ENSMUSP00000011493","abundance":0.35,"rank":14585,"name":"Dmrtc2","annotation":"Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family."},{"id":"ENSMUSP00000062635","abundance":0.35,"rank":14586,"name":"Tram1l1","annotation":"Translocating chain-associated membrane protein 1-like 1; Stimulatory or required for the translocation of secretory proteins across the ER membrane; Belongs to the TRAM family."},{"id":"ENSMUSP00000034791","abundance":0.35,"rank":14587,"name":"Lca5","annotation":"Lebercilin; Involved in intraflagellar protein (IFT) transport in photoreceptor cilia."},{"id":"ENSMUSP00000076321","abundance":0.35,"rank":14588,"name":"Tmem151a","annotation":"Transmembrane protein 151A."},{"id":"ENSMUSP00000030510","abundance":0.35,"rank":14589,"name":"Tas1r2","annotation":"Taste receptor type 1 member 2; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners."},{"id":"ENSMUSP00000140504","abundance":0.35,"rank":14590,"name":"Gm28845","annotation":"Predicted gene 28845."},{"id":"ENSMUSP00000065379","abundance":0.35,"rank":14591,"name":"Zfp229","annotation":"Zinc finger protein 229."},{"id":"ENSMUSP00000102075","abundance":0.349,"rank":14592,"name":"Rwdd3","annotation":"RWD domain-containing protein 3; Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regula [...] "},{"id":"ENSMUSP00000127662","abundance":0.349,"rank":14593,"name":"Dtwd1","annotation":"DTW domain-containing protein 1."},{"id":"ENSMUSP00000062837","abundance":0.349,"rank":14594,"name":"Erich3","annotation":"Glutamate-rich 3."},{"id":"ENSMUSP00000138293","abundance":0.349,"rank":14595,"name":"Sox12","annotation":"Transcription factor SOX-12; Binds to the sequence 5'-AACAAT-3'."},{"id":"ENSMUSP00000056483","abundance":0.349,"rank":14596,"name":"Prss27","annotation":"Serine protease 27."},{"id":"ENSMUSP00000023068","abundance":0.349,"rank":14597,"name":"Smc1b","annotation":"Structural maintenance of chromosomes protein 1B; Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, t [...] "},{"id":"ENSMUSP00000089463","abundance":0.349,"rank":14598,"name":"Mex3c","annotation":"RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation."},{"id":"ENSMUSP00000130057","abundance":0.348,"rank":14599,"name":"Slitrk2","annotation":"SLIT and NTRK-like protein 2; It is involved in synaptogenesis. Promotes excitatory synapse differentiation (By similarity). Suppresses neurite outgrowth."},{"id":"ENSMUSP00000120881","abundance":0.348,"rank":14600,"name":"Cd84","annotation":"SLAM family member 5; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferativ [...] "},{"id":"ENSMUSP00000092725","abundance":0.348,"rank":14601,"name":"Ccin","annotation":"Calicin; Possible morphogenetic cytoskeletal element in spermiogenic differentiation."},{"id":"ENSMUSP00000071466","abundance":0.348,"rank":14602,"name":"Mgam","annotation":"Maltase-glucoamylase."},{"id":"ENSMUSP00000041767","abundance":0.348,"rank":14603,"name":"Snapc4","annotation":"snRNA-activating protein complex subunit 4; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)."},{"id":"ENSMUSP00000114099","abundance":0.348,"rank":14604,"name":"Crybg2","annotation":"Crystallin beta-gamma domain-containing 2; Belongs to the beta/gamma-crystallin family."},{"id":"ENSMUSP00000058007","abundance":0.348,"rank":14605,"name":"Crb2","annotation":"Protein crumbs homolog 2; Apical polarity protein that plays a central role during the epithelial-to-mesenchymal transition (EMT) at gastrulation, when newly specified mesodermal cells move inside the embryo. Acts by promoting cell ingression, the process by which cells leave the epithelial epiblast and move inside the embryo to form a new tissue layer. The anisotropic distribution of CRB2 and MYH10/myosin-IIB at cell edges define which cells will ingress: cells with high apical CRB2 are probably extruded from the epiblast by neighboring cells with high levels of apical MYH10/myosin- I [...] "},{"id":"ENSMUSP00000030142","abundance":0.348,"rank":14606,"name":"Epb41l4b","annotation":"Band 4.1-like protein 4B; Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18. Involved in the regulation of the circumferential actomyosin belt in epithelial cells. Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (By similarity). May have a role in mediating cytoskeletal changes associated with steroid- induced cell differentiation (By similarity)."},{"id":"ENSMUSP00000031420","abundance":0.347,"rank":14607,"name":"Gpn3","annotation":"GPN-loop GTPase 3; Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family."},{"id":"ENSMUSP00000075601","abundance":0.347,"rank":14608,"name":"Zfp865","annotation":"Zinc finger protein 865; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000040938","abundance":0.347,"rank":14609,"name":"Wdr92","annotation":"WD repeat-containing protein 92; Seems to act as a modulator of apoptosis."},{"id":"ENSMUSP00000114166","abundance":0.347,"rank":14610,"name":"Paqr6","annotation":"Membrane progestin receptor delta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. Involved in neurosteroid inhibition of apoptosis. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone; Belongs to the ADIPOR family."},{"id":"ENSMUSP00000023468","abundance":0.347,"rank":14611,"name":"Spag6l","annotation":"Sperm-associated antigen 6; Important for structural integrity of the central apparatus in the sperm tail and for flagellar motility."},{"id":"ENSMUSP00000106606","abundance":0.347,"rank":14612,"name":"Pilrb1","annotation":"Paired immunoglobulin-like type 2 receptor beta; Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. Seems to associate with DAP12 and is a receptor for CD99. May be involved in target cell recognition by natural killer cells and in activation of dendritic cells."},{"id":"ENSMUSP00000158500","abundance":0.347,"rank":14613,"name":"Vps37c","annotation":"Vacuolar protein sorting-associated protein 37C; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation (By similarity)."},{"id":"ENSMUSP00000124524","abundance":0.347,"rank":14614,"name":"Fbxo41","annotation":"F-box only protein 41; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000000466","abundance":0.347,"rank":14615,"name":"Plin2","annotation":"Perilipin-2; May be involved in development and maintenance of adipose tissue."},{"id":"ENSMUSP00000095379","abundance":0.347,"rank":14616,"name":"Il1rl1","annotation":"Interleukin-1 receptor-like 1; Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function."},{"id":"ENSMUSP00000060640","abundance":0.347,"rank":14617,"name":"Slc9b2","annotation":"Sodium/hydrogen exchanger 9B2; Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane. Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells. Involved in sperm motility and fertility. It is controversial whether SLC9B2 plays a role in osteoclast differentiation  or not. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family."},{"id":"ENSMUSP00000022646","abundance":0.347,"rank":14618,"name":"Nkx3-1","annotation":"Homeobox protein Nkx-3.1; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor (By similarity). Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells. Plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). Essential for [...] "},{"id":"ENSMUSP00000131895","abundance":0.346,"rank":14619,"name":"Snx19","annotation":"Sorting nexin-19; Plays a role in intracellular vesicle trafficking and exocytosis. May play a role in maintaining insulin- containing dense core vesicles in pancreatic beta-cells and in preventing their degradation. May play a role in insulin secretion. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Belongs to the sorting nexin family."},{"id":"ENSMUSP00000078690","abundance":0.346,"rank":14620,"name":"Cpeb3","annotation":"Cytoplasmic polyadenylation element-binding protein 3; Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptor [...] "},{"id":"ENSMUSP00000101323","abundance":0.346,"rank":14621,"name":"Gm572","annotation":"Predicted gene 572."},{"id":"ENSMUSP00000130232","abundance":0.346,"rank":14622,"name":"Stra6","annotation":"Receptor for retinol uptake STRA6; Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol- binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A (By similarity). Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activati [...] "},{"id":"ENSMUSP00000020289","abundance":0.346,"rank":14623,"name":"Pald1","annotation":"Paladin."},{"id":"ENSMUSP00000134666","abundance":0.346,"rank":14624,"name":"Gprasp2","annotation":"G-protein coupled receptor-associated sorting protein 2; May play a role in regulation of a variety of G-protein coupled receptors."},{"id":"ENSMUSP00000034091","abundance":0.346,"rank":14625,"name":"Rbl2","annotation":"Retinoblastoma-like protein 2; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially [...] "},{"id":"ENSMUSP00000047320","abundance":0.345,"rank":14626,"name":"Trmt13","annotation":"tRNA:m(4)X modification enzyme TRM13 homolog; tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). Belongs to the methyltransferase TRM13 family."},{"id":"ENSMUSP00000005108","abundance":0.345,"rank":14627,"name":"Kdm5a","annotation":"Lysine-specific demethylase 5A; Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif. May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (By similarity). May participate in trans [...] "},{"id":"ENSMUSP00000033941","abundance":0.345,"rank":14628,"name":"Plat","annotation":"Tissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000077323","abundance":0.345,"rank":14629,"name":"Magea1","annotation":"Melanoma antigen, family A, 1."},{"id":"ENSMUSP00000105240","abundance":0.345,"rank":14630,"name":"Fer1l4","annotation":"Fer-1-like protein 4."},{"id":"ENSMUSP00000022051","abundance":0.345,"rank":14631,"name":"Nkd2","annotation":"Protein naked cuticle homolog 2; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells (By similarity); Belongs to the NKD family."},{"id":"ENSMUSP00000032909","abundance":0.345,"rank":14632,"name":"Pde3b","annotation":"cGMP-inhibited 3',5'-cyclic phosphodiesterase B; Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis (By similarity)."},{"id":"ENSMUSP00000016086","abundance":0.344,"rank":14633,"name":"Gtf2ird2","annotation":"General transcription factor II-I repeat domain-containing protein 2."},{"id":"ENSMUSP00000085471","abundance":0.344,"rank":14634,"name":"4930415L06Rik","annotation":"Protein PPP4R3C; Belongs to the SMEK family."},{"id":"ENSMUSP00000074490","abundance":0.344,"rank":14635,"name":"Bud13","annotation":"BUD13 homolog; Involved in pre-mRNA splicing as component of the activated spliceosome; Belongs to the CWC26 family."},{"id":"ENSMUSP00000096196","abundance":0.344,"rank":14636,"name":"Zfp382","annotation":"Zinc finger protein 382; Functions as a sequence-specific transcriptional repressor."},{"id":"ENSMUSP00000047589","abundance":0.344,"rank":14637,"name":"Smarcal1","annotation":"SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks ( [...] "},{"id":"ENSMUSP00000097574","abundance":0.344,"rank":14638,"name":"Ttc30a1","annotation":"Tetratricopeptide repeat protein 30A1; Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip; Belongs to the TTC30/dfy-1/fleer family."},{"id":"ENSMUSP00000045333","abundance":0.343,"rank":14639,"name":"Pcdh8","annotation":"Protocadherin-8; Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway (By similarity). In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis."},{"id":"ENSMUSP00000095300","abundance":0.343,"rank":14640,"name":"Retreg2","annotation":"Reticulophagy regulator 2."},{"id":"ENSMUSP00000140857","abundance":0.343,"rank":14641,"name":"Cyp4a30b","annotation":"Cytochrome P450, family 4, subfamily a, polypeptide 30b; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000067603","abundance":0.343,"rank":14642,"name":"Lcor","annotation":"Ligand-dependent corepressor; Repressor of ligand-dependent transcription activation by various nuclear repressors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR (By similarity). May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'."},{"id":"ENSMUSP00000037136","abundance":0.343,"rank":14643,"name":"Disp2","annotation":"Protein dispatched homolog 2; Belongs to the dispatched family."},{"id":"ENSMUSP00000022718","abundance":0.343,"rank":14644,"name":"Ednrb","annotation":"Endothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily."},{"id":"ENSMUSP00000126474","abundance":0.342,"rank":14645,"name":"Ccdc159","annotation":"Coiled-coil domain-containing protein 159."},{"id":"ENSMUSP00000130207","abundance":0.342,"rank":14646,"name":"Jakmip3","annotation":"Janus kinase and microtubule-interacting protein 3; Belongs to the JAKMIP family."},{"id":"ENSMUSP00000095303","abundance":0.342,"rank":14647,"name":"Catip","annotation":"Ciliogenesis-associated TTC17-interacting protein; Plays a role in primary ciliogenesis by modulating actin polymerization; Belongs to the CATIP family."},{"id":"ENSMUSP00000022563","abundance":0.342,"rank":14648,"name":"Mtmr6","annotation":"Myotubularin-related protein 6; Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (By similarity). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association wi [...] "},{"id":"ENSMUSP00000047278","abundance":0.342,"rank":14649,"name":"Calhm2","annotation":"Calcium homeostasis modulator protein 2; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family."},{"id":"ENSMUSP00000133152","abundance":0.342,"rank":14650,"name":"Zbtb42","annotation":"Zinc finger and BTB domain-containing protein 42; Transcriptional repressor. Specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes; Belongs to the krueppel C2H2-type zinc-finger protein family. ZBTB18 subfamily."},{"id":"ENSMUSP00000110380","abundance":0.342,"rank":14651,"name":"Ephb6","annotation":"Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity)."},{"id":"ENSMUSP00000044990","abundance":0.342,"rank":14652,"name":"Phf12","annotation":"PHD finger protein 12; Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (By similarity)."},{"id":"ENSMUSP00000129557","abundance":0.342,"rank":14653,"name":"Nynrin","annotation":"Protein NYNRIN."},{"id":"ENSMUSP00000050992","abundance":0.342,"rank":14654,"name":"Rpp38","annotation":"Ribonuclease P protein subunit p38; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences; Belongs to the eukaryotic ribosomal protein eL8 family."},{"id":"ENSMUSP00000000543","abundance":0.342,"rank":14655,"name":"Grasp","annotation":"General receptor for phosphoinositides 1-associated scaffold protein; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses."},{"id":"ENSMUSP00000058047","abundance":0.342,"rank":14656,"name":"F830045P16Rik","annotation":"RIKEN cDNA F830045P16 gene."},{"id":"ENSMUSP00000039950","abundance":0.342,"rank":14657,"name":"Pmepa1","annotation":"Protein TMEPAI; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may  [...] "},{"id":"ENSMUSP00000039175","abundance":0.341,"rank":14658,"name":"Nr0b2","annotation":"Nuclear receptor subfamily 0 group B member 2; Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2- mediated hepatic lipid metabolism. Regulates the [...] "},{"id":"ENSMUSP00000035948","abundance":0.341,"rank":14659,"name":"Fbxo33","annotation":"F-box only protein 33; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Recognizes YBX1."},{"id":"ENSMUSP00000032207","abundance":0.341,"rank":14660,"name":"Klrg1","annotation":"Killer cell lectin-like receptor subfamily G member 1; Plays an inhibitory role on natural killer (NK) cells and T- cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E- cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells."},{"id":"ENSMUSP00000050773","abundance":0.341,"rank":14661,"name":"Mapk8ip1","annotation":"C-Jun-amino-terminal kinase-interacting protein 1; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and thus inhibiting the JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly, or indirectly, regulates GLUT2 gene expression and beta-cell fu [...] "},{"id":"ENSMUSP00000132781","abundance":0.341,"rank":14662,"name":"Ifit1bl1","annotation":"Interferon-induced protein with tetratricpeptide repeats 1B-like 1."},{"id":"ENSMUSP00000102441","abundance":0.341,"rank":14663,"name":"Trim30c","annotation":"Tripartite motif-containing 30C."},{"id":"ENSMUSP00000147542","abundance":0.341,"rank":14664,"name":"Gm45871","annotation":"Zinc finger protein."},{"id":"ENSMUSP00000152227","abundance":0.341,"rank":14665,"name":"Gm30302","annotation":"Predicted gene, 30302."},{"id":"ENSMUSP00000114114","abundance":0.341,"rank":14666,"name":"Fzd10","annotation":"Frizzled-10; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both [...] "},{"id":"ENSMUSP00000128423","abundance":0.341,"rank":14667,"name":"Atp8b2","annotation":"Phospholipid-transporting ATPase ID; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (By similarity); Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily."},{"id":"ENSMUSP00000062212","abundance":0.34,"rank":14668,"name":"Has2","annotation":"Hyaluronan synthase 2; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. M [...] "},{"id":"ENSMUSP00000069644","abundance":0.34,"rank":14669,"name":"Adamts8","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 8; Has anti-angiogenic properties."},{"id":"ENSMUSP00000074619","abundance":0.34,"rank":14670,"name":"Zxdc","annotation":"Zinc finger protein ZXDC; Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes."},{"id":"ENSMUSP00000033611","abundance":0.34,"rank":14671,"name":"Xkrx","annotation":"XK-related protein 2."},{"id":"ENSMUSP00000135400","abundance":0.34,"rank":14672,"name":"Large2","annotation":"LARGE xylosyl- and glucuronyltransferase 2; Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by  [...] "},{"id":"ENSMUSP00000004985","abundance":0.34,"rank":14673,"name":"Brpf3","annotation":"Bromodomain and PHD finger-containing, 3."},{"id":"ENSMUSP00000084353","abundance":0.34,"rank":14674,"name":"Cenpq","annotation":"Centromere protein Q; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores."},{"id":"ENSMUSP00000092751","abundance":0.34,"rank":14675,"name":"Spag6","annotation":"Sperm-associated antigen 6."},{"id":"ENSMUSP00000135966","abundance":0.339,"rank":14676,"name":"Ccdc162","annotation":"Coiled-coil domain-containing protein 162."},{"id":"ENSMUSP00000060890","abundance":0.339,"rank":14677,"name":"Cox7b2","annotation":"Cytochrome c oxidase subunit VIIb2."},{"id":"ENSMUSP00000068997","abundance":0.339,"rank":14678,"name":"Usp17la","annotation":"Ubiquitin carboxyl-terminal hydrolase 17-like protein A; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Has deubiquitinating enzyme activity for DNAH5, suggesting a role in the regulation of DNAH5 degradation by the ubiquitin-proteasome pathway. Has growth-suppressing activity; induces arrest in G1 phase upon controlled expression."},{"id":"ENSMUSP00000093497","abundance":0.339,"rank":14679,"name":"Ect2l","annotation":"Epithelial cell-transforming sequence 2 oncogene-like."},{"id":"ENSMUSP00000092494","abundance":0.339,"rank":14680,"name":"Trabd2b","annotation":"Metalloprotease TIKI2; Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation (By similarity)."},{"id":"ENSMUSP00000006397","abundance":0.339,"rank":14681,"name":"Epor","annotation":"Erythropoietin receptor; Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase."},{"id":"ENSMUSP00000071905","abundance":0.339,"rank":14682,"name":"Tle6","annotation":"Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions."},{"id":"ENSMUSP00000121870","abundance":0.338,"rank":14683,"name":"Skint6","annotation":"Selection and upkeep of intraepithelial T-cells protein 6; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus."},{"id":"ENSMUSP00000014848","abundance":0.338,"rank":14684,"name":"Hoxa2","annotation":"Homeobox protein Hox-A2; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. Proboscipedia subfamily."},{"id":"ENSMUSP00000074581","abundance":0.338,"rank":14685,"name":"Gpr65","annotation":"Psychosine receptor; Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids (By similarity). Plays a role in immune response by maintaining lysosome function and supporting phagocytosis-mediated intracellular bacteria clearance. May have a role in activation-induced cell death or differentiation of T-cells."},{"id":"ENSMUSP00000046645","abundance":0.338,"rank":14686,"name":"Ift57","annotation":"Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. Belongs to the IFT57 family."},{"id":"ENSMUSP00000039808","abundance":0.338,"rank":14687,"name":"Prss22","annotation":"Brain-specific serine protease 4; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000056080","abundance":0.338,"rank":14688,"name":"Gldn","annotation":"Gliomedin shedded ectodomain; Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of  [...] "},{"id":"ENSMUSP00000124967","abundance":0.337,"rank":14689,"name":"Smok2b","annotation":"Sperm motility kinase 2B; May play a role in sperm motility, especially in the regulation of flagellar function."},{"id":"ENSMUSP00000137785","abundance":0.337,"rank":14690,"name":"Gm27021","annotation":"Predicted gene, 27021."},{"id":"ENSMUSP00000102550","abundance":0.337,"rank":14691,"name":"Art5","annotation":"Ecto-ADP-ribosyltransferase 5; Belongs to the Arg-specific ADP-ribosyltransferase family."},{"id":"ENSMUSP00000071670","abundance":0.337,"rank":14692,"name":"Gm14496","annotation":"Predicted gene 14496."},{"id":"ENSMUSP00000039170","abundance":0.337,"rank":14693,"name":"Hoxa13","annotation":"Homeobox protein Hox-A13; Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis."},{"id":"ENSMUSP00000046028","abundance":0.336,"rank":14694,"name":"Tmc3","annotation":"Transmembrane channel-like protein 3; Probable ion channel; Belongs to the TMC family."},{"id":"ENSMUSP00000078547","abundance":0.336,"rank":14695,"name":"Paqr9","annotation":"Membrane progesterone receptor epsilon; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(s) mediated pathway. May be involved in regulating rapid P4 signaling in the nervous system. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone; Belongs to the ADIPOR family."},{"id":"ENSMUSP00000097713","abundance":0.336,"rank":14696,"name":"Igll1","annotation":"Immunoglobulin lambda-like polypeptide 1; Critical for B-cell development."},{"id":"ENSMUSP00000045272","abundance":0.336,"rank":14697,"name":"Alg3","annotation":"Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol; Belongs to the glycosyltransferase 58 family."},{"id":"ENSMUSP00000044245","abundance":0.336,"rank":14698,"name":"Prdm14","annotation":"PR domain zinc finger protein 14; Transcription factor that has both positive and negative roles on transcription (By similarity). Plays a role in cellular pluripotency. Essential for germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation; Belongs to the class V-like SAM-binding methyltransferase superfamily."},{"id":"ENSMUSP00000124518","abundance":0.336,"rank":14699,"name":"Hephl1","annotation":"Ferroxidase HEPHL1; Is a copper-binding glycoprotein with ferroxidase activity. It oxidizes Fe(2+) to Fe(3+) without releasing radical oxygen species. May be involved in the regulation of intracellular iron content."},{"id":"ENSMUSP00000038130","abundance":0.336,"rank":14700,"name":"Stap2","annotation":"Signal-transducing adaptor protein 2; Substrate of protein kinase PTK6 (By similarity). May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity."},{"id":"ENSMUSP00000128530","abundance":0.336,"rank":14701,"name":"4931428F04Rik","annotation":"Uncharacterized protein KIAA0895-like."},{"id":"ENSMUSP00000050820","abundance":0.336,"rank":14702,"name":"Zfp36l2","annotation":"mRNA decay activator protein ZFP36L2; Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (By similarity). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, a [...] "},{"id":"ENSMUSP00000031718","abundance":0.336,"rank":14703,"name":"Pax4","annotation":"Paired box protein Pax-4; Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that competes with PAX6 in binding to a common element in the glucagon, insulin and somatostatin promoters; Belongs to the paired homeobox family."},{"id":"ENSMUSP00000044069","abundance":0.335,"rank":14704,"name":"Zfc3h1","annotation":"Zinc finger, C3H1-type-containing."},{"id":"ENSMUSP00000140479","abundance":0.335,"rank":14705,"name":"Mei1","annotation":"Meiosis inhibitor protein 1; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes."},{"id":"ENSMUSP00000114895","abundance":0.335,"rank":14706,"name":"Mus81","annotation":"Crossover junction endonuclease MUS81; Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks."},{"id":"ENSMUSP00000102783","abundance":0.335,"rank":14707,"name":"Tenm4","annotation":"Teneurin-4; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer; Belongs to the tenascin family. Teneurin subfamily."},{"id":"ENSMUSP00000103710","abundance":0.335,"rank":14708,"name":"Usp32","annotation":"Ubiquitin-specific peptidase 32; Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000036380","abundance":0.335,"rank":14709,"name":"Fcrla","annotation":"Fc receptor-like A; May be implicated in B-cell differentiation and lymphomagenesis."},{"id":"ENSMUSP00000153749","abundance":0.335,"rank":14710,"name":"Vmn1r31","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000039955","abundance":0.334,"rank":14711,"name":"Cblc","annotation":"E3 ubiquitin-protein ligase CBL-C; Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-424', has the highest ubiquitin ligase activity among CBL family [...] "},{"id":"ENSMUSP00000053977","abundance":0.333,"rank":14712,"name":"Inhbe","annotation":"Inhibin beta E chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000103485","abundance":0.333,"rank":14713,"name":"Mbtd1","annotation":"MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4 (By similarity)."},{"id":"ENSMUSP00000098903","abundance":0.333,"rank":14714,"name":"Atoh1","annotation":"Protein atonal homolog 1; Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription."},{"id":"ENSMUSP00000016696","abundance":0.333,"rank":14715,"name":"Foxred2","annotation":"FAD-dependent oxidoreductase domain-containing protein 2; Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation (By similarity)."},{"id":"ENSMUSP00000107793","abundance":0.333,"rank":14716,"name":"Tlr8","annotation":"Toll-like receptor 8; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B. activation, cytokine secretion and the inflammatory response (By similarity)."},{"id":"ENSMUSP00000068846","abundance":0.333,"rank":14717,"name":"Pcdhgc4","annotation":"Protocadherin gamma subfamily C, 4."},{"id":"ENSMUSP00000106782","abundance":0.332,"rank":14718,"name":"Ssc4d","annotation":"Scavenger receptor cysteine-rich domain-containing group B protein."},{"id":"ENSMUSP00000157063","abundance":0.332,"rank":14719,"name":"Cdkl4","annotation":"Cyclin-dependent kinase-like 4; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."},{"id":"ENSMUSP00000033877","abundance":0.332,"rank":14720,"name":"Brf2","annotation":"Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family."},{"id":"ENSMUSP00000137185","abundance":0.332,"rank":14721,"name":"LOC100041806","annotation":"PRAME family member 9/15-like."},{"id":"ENSMUSP00000095098","abundance":0.332,"rank":14722,"name":"LOC100861655","annotation":"Predicted gene 6367."},{"id":"ENSMUSP00000139603","abundance":0.332,"rank":14723,"name":"Gm6205","annotation":"Predicted gene 6205."},{"id":"ENSMUSP00000139318","abundance":0.332,"rank":14724,"name":"Aspa","annotation":"Aspartoacylase; Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity)."},{"id":"ENSMUSP00000093240","abundance":0.332,"rank":14725,"name":"Mypn","annotation":"Myopalladin; Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines."},{"id":"ENSMUSP00000030257","abundance":0.332,"rank":14726,"name":"Cachd1","annotation":"VWFA and cache domain-containing protein 1; May regulate voltage-dependent calcium channels."},{"id":"ENSMUSP00000141341","abundance":0.332,"rank":14727,"name":"Zfp639","annotation":"Zinc finger protein 639; Binds DNA and may function as a transcriptional repressor."},{"id":"ENSMUSP00000045629","abundance":0.331,"rank":14728,"name":"A4gnt","annotation":"Alpha-1,4-N-acetylglucosaminyltransferase; Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct. May protect against inflammation-associated gastric adenocarcinoma."},{"id":"ENSMUSP00000056378","abundance":0.331,"rank":14729,"name":"Ttc12","annotation":"Tetratricopeptide repeat protein 12."},{"id":"ENSMUSP00000049474","abundance":0.331,"rank":14730,"name":"Zswim5","annotation":"Zinc finger SWIM domain-containing protein 5."},{"id":"ENSMUSP00000034594","abundance":0.331,"rank":14731,"name":"Il10ra","annotation":"Interleukin-10 receptor subunit alpha; Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellul [...] "},{"id":"ENSMUSP00000086141","abundance":0.331,"rank":14732,"name":"Zfp946","annotation":"Zinc finger protein 946."},{"id":"ENSMUSP00000030279","abundance":0.331,"rank":14733,"name":"Atg4c","annotation":"Cysteine protease ATG4C; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). Is not essential for autophagy development under normal conditions but is required for a proper au [...] "},{"id":"ENSMUSP00000105282","abundance":0.331,"rank":14734,"name":"Zfp423","annotation":"Zinc finger protein 423; Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmenta [...] "},{"id":"ENSMUSP00000026500","abundance":0.331,"rank":14735,"name":"Avil","annotation":"Advillin; Ca(2+)-regulated actin-binding protein. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates. Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis; Belongs to the villin/gelsolin family."},{"id":"ENSMUSP00000022622","abundance":0.331,"rank":14736,"name":"Ptk2b","annotation":"Protein-tyrosine kinase 2-beta; Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promot [...] "},{"id":"ENSMUSP00000110762","abundance":0.33,"rank":14737,"name":"Hyls1","annotation":"Hydrolethalus syndrome protein 1 homolog; Plays a role in ciliogenesis. Belongs to the HYLS1 family."},{"id":"ENSMUSP00000113864","abundance":0.33,"rank":14738,"name":"Glt1d1","annotation":"Glycosyltransferase 1 domain-containing protein 1; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily."},{"id":"ENSMUSP00000040022","abundance":0.33,"rank":14739,"name":"Flywch1","annotation":"FLYWCH-type zinc finger-containing protein 1."},{"id":"ENSMUSP00000149391","abundance":0.329,"rank":14740,"name":"Olfr787","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000150656","abundance":0.329,"rank":14741,"name":"Olfr776","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000034056","abundance":0.329,"rank":14742,"name":"Tlr3","annotation":"Toll-like receptor 3; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity)."},{"id":"ENSMUSP00000003049","abundance":0.329,"rank":14743,"name":"Med25","annotation":"Mediator of RNA polymerase II transcription subunit 25; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-m [...] "},{"id":"ENSMUSP00000139027","abundance":0.329,"rank":14744,"name":"Unc13c","annotation":"Protein unc-13 homolog C; May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses; Belongs to the unc-13 family."},{"id":"ENSMUSP00000079137","abundance":0.328,"rank":14745,"name":"Zfp947","annotation":"Predicted gene, EG210853."},{"id":"ENSMUSP00000020699","abundance":0.328,"rank":14746,"name":"Castor1","annotation":"Cytosolic arginine sensor for mTORC1 subunit 1; Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway; Belongs to the GATS family."},{"id":"ENSMUSP00000111222","abundance":0.328,"rank":14747,"name":"Yeats2","annotation":"YEATS domain-containing protein 2; Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors."},{"id":"ENSMUSP00000109161","abundance":0.328,"rank":14748,"name":"Sac3d1","annotation":"SAC3 domain-containing protein 1; Involved in centrosome duplication and mitotic progression. Belongs to the SAC3 family."},{"id":"ENSMUSP00000104728","abundance":0.328,"rank":14749,"name":"Fam186b","annotation":"Family with sequence similarity 186, member B."},{"id":"ENSMUSP00000110844","abundance":0.328,"rank":14750,"name":"Rhox2c","annotation":"Reproductive homeobox 2C."},{"id":"ENSMUSP00000076449","abundance":0.328,"rank":14751,"name":"Olfr304","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000136289","abundance":0.327,"rank":14752,"name":"Zdhhc25","annotation":"Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family."},{"id":"ENSMUSP00000024696","abundance":0.327,"rank":14753,"name":"Mmp25","annotation":"Matrix metalloproteinase-25; May activate progelatinase A; Belongs to the peptidase M10A family."},{"id":"ENSMUSP00000021251","abundance":0.327,"rank":14754,"name":"Lrrc46","annotation":"Leucine-rich repeat-containing protein 46."},{"id":"ENSMUSP00000044437","abundance":0.327,"rank":14755,"name":"Dop1b","annotation":"Protein dopey-2; May be involved in protein traffic between late Golgi and early endosomes."},{"id":"ENSMUSP00000045808","abundance":0.327,"rank":14756,"name":"Abca8a","annotation":"ATP-binding cassette sub-family A member 8-A; ATP-dependent lipophilic drug transporter."},{"id":"ENSMUSP00000093379","abundance":0.327,"rank":14757,"name":"Slc5a7","annotation":"High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family."},{"id":"ENSMUSP00000128994","abundance":0.327,"rank":14758,"name":"Gm8374","annotation":"Predicted gene 8374."},{"id":"ENSMUSP00000036049","abundance":0.327,"rank":14759,"name":"Zfp623","annotation":"Brain specific protein 5."},{"id":"ENSMUSP00000148536","abundance":0.327,"rank":14760,"name":"Sipa1l2","annotation":"Signal-induced proliferation-associated 1-like protein 2."},{"id":"ENSMUSP00000030792","abundance":0.327,"rank":14761,"name":"Tas1r1","annotation":"Taste receptor type 1 member 1; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses."},{"id":"ENSMUSP00000100012","abundance":0.327,"rank":14762,"name":"E2f3","annotation":"Transcription factor E2F3; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters. Belongs to the E2F/DP family."},{"id":"ENSMUSP00000072030","abundance":0.327,"rank":14763,"name":"Rhox2e","annotation":"Reproductive homeobox 2E."},{"id":"ENSMUSP00000067190","abundance":0.327,"rank":14764,"name":"Rhox2a","annotation":"Reproductive homeobox on X chromosome 2."},{"id":"ENSMUSP00000079789","abundance":0.326,"rank":14765,"name":"Tmem26","annotation":"Transmembrane protein 26."},{"id":"ENSMUSP00000149479","abundance":0.326,"rank":14766,"name":"Olfr1511","annotation":"Olfactory receptor 1511."},{"id":"ENSMUSP00000017694","abundance":0.326,"rank":14767,"name":"Atad5","annotation":"ATPase family AAA domain-containing protein 5; Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis."},{"id":"ENSMUSP00000099659","abundance":0.326,"rank":14768,"name":"Sync","annotation":"Syncoilin; Atypical type III intermediate filament (IF) protein that may play a supportive role in the efficient coupling of mechanical stress between the myofibril and fiber exterior. May facilitate lateral force transmission during skeletal muscle contraction. Does not form homofilaments nor heterofilaments with other IF proteins."},{"id":"ENSMUSP00000102352","abundance":0.326,"rank":14769,"name":"Trim66","annotation":"Tripartite motif-containing protein 66; May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association."},{"id":"ENSMUSP00000126665","abundance":0.326,"rank":14770,"name":"Zfp712","annotation":"Zinc finger protein 712."},{"id":"ENSMUSP00000092828","abundance":0.326,"rank":14771,"name":"Rasgrp3","annotation":"RAS, guanyl-releasing protein 3."},{"id":"ENSMUSP00000034734","abundance":0.326,"rank":14772,"name":"Dnaaf4","annotation":"Dynein assembly factor 4, axonemal; Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity (By similarity). Axonemal dynein assembly factor required for ciliary motility."},{"id":"ENSMUSP00000074159","abundance":0.326,"rank":14773,"name":"Unc5cl","annotation":"UNC5C-like protein; Inhibits NF-kappa-B-dependent transcription by impairing NF- kappa-B binding to its targets; Belongs to the unc-5 family."},{"id":"ENSMUSP00000064527","abundance":0.325,"rank":14774,"name":"Tmprss5","annotation":"Transmembrane protease serine 5; May play a role in hearing."},{"id":"ENSMUSP00000079295","abundance":0.325,"rank":14775,"name":"Dennd5a","annotation":"DENN domain-containing protein 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). Involved in the negative regulation of neurite outgrowth (By similarity); Belongs to the RAB6IP1 family."},{"id":"ENSMUSP00000115754","abundance":0.325,"rank":14776,"name":"Slc35e1","annotation":"Solute carrier family 35 member E1; Putative transporter; Belongs to the TPT transporter family. SLC35E subfamily."},{"id":"ENSMUSP00000031077","abundance":0.325,"rank":14777,"name":"Zcchc4","annotation":"rRNA N6-adenosine-methyltransferase ZCCHC4; rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation. Belongs to the ZCCHC4 family."},{"id":"ENSMUSP00000060100","abundance":0.325,"rank":14778,"name":"Trim12c","annotation":"Tripartite motif-containing 12C."},{"id":"ENSMUSP00000055321","abundance":0.325,"rank":14779,"name":"Bbs1","annotation":"Bardet-Biedl syndrome 1 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the gua [...] "},{"id":"ENSMUSP00000049046","abundance":0.325,"rank":14780,"name":"Pif1","annotation":"ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] "},{"id":"ENSMUSP00000081867","abundance":0.325,"rank":14781,"name":"Dnah11","annotation":"Dynein, axonemal, heavy chain 11."},{"id":"ENSMUSP00000054420","abundance":0.325,"rank":14782,"name":"Fam120b","annotation":"Constitutive coactivator of peroxisome proliferator-activated receptor gamma; Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation."},{"id":"ENSMUSP00000139581","abundance":0.324,"rank":14783,"name":"Zfp995","annotation":"Zinc finger protein 995."},{"id":"ENSMUSP00000112113","abundance":0.324,"rank":14784,"name":"Ctu2","annotation":"Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the CTU2/NCS2 family."},{"id":"ENSMUSP00000107284","abundance":0.324,"rank":14785,"name":"Tcf7l2","annotation":"Transcription factor 7-like 2; Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compa [...] "},{"id":"ENSMUSP00000150357","abundance":0.324,"rank":14786,"name":"Olfr905","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000019051","abundance":0.324,"rank":14787,"name":"Alox12e","annotation":"Arachidonate 12-lipoxygenase, epidermal-type; Non-heme iron-containing dioxygenase that probably catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. May preferentially convert arachidonic acid to (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE. Belongs to the lipoxygenase family."},{"id":"ENSMUSP00000061168","abundance":0.324,"rank":14788,"name":"Ankrd23","annotation":"Ankyrin repeat domain-containing protein 23; May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression."},{"id":"ENSMUSP00000142910","abundance":0.323,"rank":14789,"name":"Ccdc144b","annotation":"Coiled-coil domain-containing 144B."},{"id":"ENSMUSP00000123563","abundance":0.323,"rank":14790,"name":"Adck2","annotation":"Uncharacterized aarF domain-containing protein kinase 2; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr)."},{"id":"ENSMUSP00000158848","abundance":0.323,"rank":14791,"name":"Gm50457","annotation":"G_PROTEIN_RECEP_F1_2 domain-containing protein."},{"id":"ENSMUSP00000108994","abundance":0.323,"rank":14792,"name":"Ddx43","annotation":"DEAD (Asp-Glu-Ala-Asp) box polypeptide 43; Belongs to the DEAD box helicase family."},{"id":"ENSMUSP00000042586","abundance":0.323,"rank":14793,"name":"Cep44","annotation":"Centrosomal protein of 44 kDa."},{"id":"ENSMUSP00000000206","abundance":0.323,"rank":14794,"name":"Btbd17","annotation":"BTB/POZ domain-containing protein 17."},{"id":"ENSMUSP00000048596","abundance":0.323,"rank":14795,"name":"Cdsn","annotation":"Corneodesmosin; Important for the epidermal barrier integrity."},{"id":"ENSMUSP00000031445","abundance":0.323,"rank":14796,"name":"Aacs","annotation":"Acetoacetyl-CoA synthetase; Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity)."},{"id":"ENSMUSP00000097024","abundance":0.322,"rank":14797,"name":"Spata31d1c","annotation":"Spermatogenesis-associated 31 subfamily D, member 1C."},{"id":"ENSMUSP00000074557","abundance":0.322,"rank":14798,"name":"Gm13084","annotation":"Predicted gene 13084."},{"id":"ENSMUSP00000027575","abundance":0.322,"rank":14799,"name":"Slco6d1","annotation":"Solute carrier organic anion transporter family, member 6d1."},{"id":"ENSMUSP00000092375","abundance":0.322,"rank":14800,"name":"Inpp5b","annotation":"Type II inositol 1,4,5-trisphosphate 5-phosphatase; Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5- trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events."},{"id":"ENSMUSP00000154041","abundance":0.322,"rank":14801,"name":"Vmn1r70","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000076255","abundance":0.322,"rank":14802,"name":"4930453N24Rik","annotation":"Uncharacterized protein C3orf38 homolog; May be involved in apoptosis regulation."},{"id":"ENSMUSP00000139535","abundance":0.322,"rank":14803,"name":"Gm21861","annotation":"RIKEN cDNA 1700040F15 gene."},{"id":"ENSMUSP00000139915","abundance":0.322,"rank":14804,"name":"Gm29582","annotation":"Predicted gene 28490."},{"id":"ENSMUSP00000140770","abundance":0.322,"rank":14805,"name":"Gm28490","annotation":"Predicted gene 28490."},{"id":"ENSMUSP00000140248","abundance":0.322,"rank":14806,"name":"Gm28891","annotation":"Predicted gene 28891."},{"id":"ENSMUSP00000140983","abundance":0.322,"rank":14807,"name":"Gm20792","annotation":"Predicted gene, 20792."},{"id":"ENSMUSP00000140263","abundance":0.322,"rank":14808,"name":"1700040F15Rik","annotation":"RIKEN cDNA 1700040F15 gene."},{"id":"ENSMUSP00000140938","abundance":0.322,"rank":14809,"name":"Gm21256","annotation":"Predicted gene, 21256."},{"id":"ENSMUSP00000140626","abundance":0.322,"rank":14810,"name":"Gm20838","annotation":"Predicted gene, 20838."},{"id":"ENSMUSP00000141113","abundance":0.322,"rank":14811,"name":"Gm21094","annotation":"Predicted gene, 21094."},{"id":"ENSMUSP00000140604","abundance":0.322,"rank":14812,"name":"Gm21739","annotation":"Predicted gene, 21739."},{"id":"ENSMUSP00000098367","abundance":0.321,"rank":14813,"name":"Duxbl3","annotation":"Double homeobox B-like 3."},{"id":"ENSMUSP00000098373","abundance":0.321,"rank":14814,"name":"Duxbl2","annotation":"Double homeobox B-like 2."},{"id":"ENSMUSP00000056056","abundance":0.321,"rank":14815,"name":"Duxbl1","annotation":"Double homeodomain protein."},{"id":"ENSMUSP00000112867","abundance":0.321,"rank":14816,"name":"Naip6","annotation":"Baculoviral IAP repeat-containing protein 1f; Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimur [...] "},{"id":"ENSMUSP00000043049","abundance":0.321,"rank":14817,"name":"Exd2","annotation":"Exonuclease 3'-5' domain-containing protein 2; Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor. In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation. Also involved in the response to DNA damage. Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient [...] "},{"id":"ENSMUSP00000029740","abundance":0.32,"rank":14818,"name":"Rnf115","annotation":"E3 ubiquitin-protein ligase RNF115; E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys- 48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4."},{"id":"ENSMUSP00000124075","abundance":0.32,"rank":14819,"name":"Zfp26","annotation":"Zinc finger protein 26; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000056967","abundance":0.32,"rank":14820,"name":"Sall3","annotation":"Sal-like protein 3; Probable transcription factor; Belongs to the sal C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000093382","abundance":0.32,"rank":14821,"name":"Bves","annotation":"Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epitheli [...] "},{"id":"ENSMUSP00000020568","abundance":0.32,"rank":14822,"name":"Wdpcp","annotation":"WD repeat-containing and planar cell polarity effector protein fritz homolog; Probable effector of the planar cell polarity signaling pathway which regulates the septin cytoskeleton in both ciliogenesis and collective cell movements. Together with FUZ and WDPCP proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies."},{"id":"ENSMUSP00000116313","abundance":0.32,"rank":14823,"name":"Setd2","annotation":"Histone-lysine N-methyltransferase SETD2; Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. It is capable of trimethylating unmethylated H3K36 (H3K36me0) in vitro (By similarity). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (By similarity). Acts as a key regulator of DNA [...] "},{"id":"ENSMUSP00000062096","abundance":0.32,"rank":14824,"name":"Tlr6","annotation":"Toll-like receptor 6; Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), so [...] "},{"id":"ENSMUSP00000050398","abundance":0.32,"rank":14825,"name":"Uckl1","annotation":"Uridine-cytidine kinase-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation."},{"id":"ENSMUSP00000138025","abundance":0.32,"rank":14826,"name":"Snx29","annotation":"Sorting nexin-29."},{"id":"ENSMUSP00000123158","abundance":0.32,"rank":14827,"name":"Ttc39d","annotation":"Tetratricopeptide repeat domain 39D."},{"id":"ENSMUSP00000130581","abundance":0.319,"rank":14828,"name":"Ralgps2","annotation":"Ras-specific guanine nucleotide-releasing factor RalGPS2; Guanine nucleotide exchange factor for the small GTPase RALA. May be involved in cytoskeletal organization. May also be involved in the stimulation of transcription in a Ras-independent fashion."},{"id":"ENSMUSP00000051521","abundance":0.319,"rank":14829,"name":"Vsig4","annotation":"V-set and immunoglobulin domain-containing 4."},{"id":"ENSMUSP00000024854","abundance":0.319,"rank":14830,"name":"Clip4","annotation":"CAP-Gly domain-containing linker protein 4."},{"id":"ENSMUSP00000143233","abundance":0.318,"rank":14831,"name":"Sass6","annotation":"Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (By similarity)."},{"id":"ENSMUSP00000048607","abundance":0.318,"rank":14832,"name":"Cer1","annotation":"Cerberus; Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part, through a BMP- inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak."},{"id":"ENSMUSP00000026096","abundance":0.318,"rank":14833,"name":"Bnc1","annotation":"Zinc finger protein basonuclin-1; Transcriptional activator. Likely specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation (By similarity). Required for the maintenance of spermatogenesis. May also play a role in the differentiation of oocytes and the early development of embryos."},{"id":"ENSMUSP00000067912","abundance":0.318,"rank":14834,"name":"Aarsd1","annotation":"Alanyl-tRNA editing protein Aarsd1; Functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala); Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily."},{"id":"ENSMUSP00000141521","abundance":0.318,"rank":14835,"name":"Pcdhb22","annotation":"Protocadherin beta 22."},{"id":"ENSMUSP00000059533","abundance":0.318,"rank":14836,"name":"Cactin","annotation":"Cactin; Involved in the regulation of innate immune response (By similarity). Acts as negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (By similarity). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli (By similarity). Belongs to the CACTIN family."},{"id":"ENSMUSP00000095103","abundance":0.318,"rank":14837,"name":"Dok6","annotation":"Docking protein 6; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance (By similarity)."},{"id":"ENSMUSP00000139672","abundance":0.317,"rank":14838,"name":"Trpc1","annotation":"Short transient receptor potential channel 1; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Seems to be also activated by intracellular calcium store depletion."},{"id":"ENSMUSP00000089777","abundance":0.317,"rank":14839,"name":"Piezo1","annotation":"Piezo-type mechanosensitive ion channel component 1; Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current- voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear- stress sensor  [...] "},{"id":"ENSMUSP00000103609","abundance":0.317,"rank":14840,"name":"Phf24","annotation":"PHD finger protein 24."},{"id":"ENSMUSP00000038562","abundance":0.317,"rank":14841,"name":"Capza3","annotation":"F-actin-capping protein subunit alpha-3; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the morphogenesis of spermatid."},{"id":"ENSMUSP00000023736","abundance":0.317,"rank":14842,"name":"Lmbr1l","annotation":"Protein LMBR1L; Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway. In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels. Acts as a LCN1 receptor and can mediate its endocytosis (By similarity); Belongs to the LIMR family."},{"id":"ENSMUSP00000051204","abundance":0.317,"rank":14843,"name":"Spem2","annotation":"Uncharacterized protein SPEM2."},{"id":"ENSMUSP00000020801","abundance":0.317,"rank":14844,"name":"Smg8","annotation":"Protein SMG8; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity)."},{"id":"ENSMUSP00000004683","abundance":0.317,"rank":14845,"name":"Mcoln1","annotation":"Mucolipin-1; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion. Involved [...] "},{"id":"ENSMUSP00000031521","abundance":0.317,"rank":14846,"name":"Cyp2w1","annotation":"Cytochrome P450 2W1; Seems to have broad catalytic activity towards several chemicals, including polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Active also in the metabolism of indoline substrates and is able to activate aflatoxin B1 into cytotoxic products. Furthermore, it seems to be involved in the oxydation of lysophospholipids and fatty acids."},{"id":"ENSMUSP00000024972","abundance":0.317,"rank":14847,"name":"Meiob","annotation":"Meiosis-specific with OB domain-containing protein; Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity i [...] "},{"id":"ENSMUSP00000048537","abundance":0.317,"rank":14848,"name":"Smyd5","annotation":"SET and MYND domain-containing protein 5."},{"id":"ENSMUSP00000022470","abundance":0.317,"rank":14849,"name":"Parg","annotation":"Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP- ribose and ADP-ribosylated residues, leaving proteins that are mono- ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental  [...] "},{"id":"ENSMUSP00000015003","abundance":0.317,"rank":14850,"name":"E2f4","annotation":"Transcription factor E2F4; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole  [...] "},{"id":"ENSMUSP00000093774","abundance":0.317,"rank":14851,"name":"Tasor2","annotation":"Protein TASOR 2; Belongs to the TASOR family."},{"id":"ENSMUSP00000021707","abundance":0.317,"rank":14852,"name":"Amn","annotation":"Soluble protein amnionless; Membrane-bound component of the endocytic receptor formed by AMN and CUBN. Required for normal CUBN glycosylation and trafficking to the cell surface. The complex formed by AMN and CUBN is required for efficient absorption of vitamin B12 (By similarity). Required for normal CUBN-mediated protein transport in the kidney."},{"id":"ENSMUSP00000046441","abundance":0.316,"rank":14853,"name":"Zer1","annotation":"Protein zer-1 homolog; Serves as substrate adapter subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC. Acts redudantly with ZYG11B to target substrates bearing N-terminal glycine degrons for proteasomal degradation. Involved in the clearance of proteolytic fragments generated by caspase cleavage during apoptosis since N-terminal glycine degrons are strongly enriched at caspase cleavage sites. Also important in the quality control of protein N-myristoylation in which N-terminal glycine degrons are conditionally exposed after a failure of N- myristoylation."},{"id":"ENSMUSP00000032413","abundance":0.316,"rank":14854,"name":"Etnk1","annotation":"Ethanolamine kinase 1; Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylathanolamine biosynthesis (By similarity); Belongs to the choline/ethanolamine kinase family."},{"id":"ENSMUSP00000047340","abundance":0.316,"rank":14855,"name":"Slc5a12","annotation":"Sodium-coupled monocarboxylate transporter 2; Acts as an electroneutral and low-affinity sodium (Na(+))- dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiomet [...] "},{"id":"ENSMUSP00000087787","abundance":0.316,"rank":14856,"name":"Dytn","annotation":"Dystrotelin."},{"id":"ENSMUSP00000150294","abundance":0.316,"rank":14857,"name":"Olfr1510","annotation":"Olfactory receptor 1510."},{"id":"ENSMUSP00000103129","abundance":0.316,"rank":14858,"name":"Syt11","annotation":"Synaptotagmin-11; Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (Probable). Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle- recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secr [...] "},{"id":"ENSMUSP00000124712","abundance":0.316,"rank":14859,"name":"Nwd2","annotation":"NACHT and WD repeat domain-containing protein 2."},{"id":"ENSMUSP00000061731","abundance":0.315,"rank":14860,"name":"Vill","annotation":"Villin-like protein; Possible tumor suppressor."},{"id":"ENSMUSP00000114769","abundance":0.314,"rank":14861,"name":"Tnrc18","annotation":"Trinucleotide repeat-containing gene 18 protein."},{"id":"ENSMUSP00000027655","abundance":0.314,"rank":14862,"name":"Ddx59","annotation":"Probable ATP-dependent RNA helicase DDX59; Belongs to the DEAD box helicase family. DDX59 subfamily."},{"id":"ENSMUSP00000109796","abundance":0.313,"rank":14863,"name":"Nacc2","annotation":"Nucleus accumbens-associated protein 2; Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53 (By similarity)."},{"id":"ENSMUSP00000090617","abundance":0.313,"rank":14864,"name":"Spns3","annotation":"Protein spinster homolog 3; Sphingolipid transporter."},{"id":"ENSMUSP00000135692","abundance":0.313,"rank":14865,"name":"Onecut2","annotation":"One cut domain family member 2; Transcriptional activator. Activates the transcription of a number of liver genes such as HNF3B (By similarity); Belongs to the CUT homeobox family."},{"id":"ENSMUSP00000043594","abundance":0.313,"rank":14866,"name":"Trpa1","annotation":"Transient receptor potential cation channel subfamily A member 1; Receptor-activated non-selective cation channel involved in pain detection and possibly also in cold perception, oxygen concentration perception, cough, itch, and inner ear function. Shows 8-fold preference for divalent over monovalent cations. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of irritants, such as allylthiocyanate (AITC) found in mustard oil or wasabi, cinnamaldehyde, diallyl disulfide (DADS) from garlic, and acrolein, an irritant from tears gas and vehi [...] "},{"id":"ENSMUSP00000071387","abundance":0.313,"rank":14867,"name":"Npdc1","annotation":"Neural proliferation differentiation and control protein 1; Suppresses oncogenic transformation in neural and non-neural cells and down-regulates neural cell proliferation. Might be involved in transcriptional regulation."},{"id":"ENSMUSP00000021377","abundance":0.313,"rank":14868,"name":"Cdkl1","annotation":"Cyclin-dependent kinase-like 1; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."},{"id":"ENSMUSP00000139522","abundance":0.313,"rank":14869,"name":"Gm29554","annotation":"Predicted gene 29554."},{"id":"ENSMUSP00000052316","abundance":0.312,"rank":14870,"name":"Klf17","annotation":"Krueppel-like factor 17; Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development."},{"id":"ENSMUSP00000120816","abundance":0.312,"rank":14871,"name":"Ankrd9","annotation":"Ankyrin repeat domain-containing protein 9."},{"id":"ENSMUSP00000060411","abundance":0.312,"rank":14872,"name":"Mrgprg","annotation":"Mas-related G-protein coupled receptor member G; Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain; Belongs to the G-protein coupled receptor 1 family. Mas subfamily."},{"id":"ENSMUSP00000030922","abundance":0.312,"rank":14873,"name":"Prkcz","annotation":"Protein kinase C zeta type; Calcium- and diacylglycerol-independent serine/threonine- protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Req [...] "},{"id":"ENSMUSP00000091289","abundance":0.312,"rank":14874,"name":"Slc22a14","annotation":"Solute carrier family 22 (Organic cation transporter), member 14."},{"id":"ENSMUSP00000129300","abundance":0.312,"rank":14875,"name":"Clp1","annotation":"Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this pho [...] "},{"id":"ENSMUSP00000146953","abundance":0.312,"rank":14876,"name":"Zfp358","annotation":"Zinc finger protein 358."},{"id":"ENSMUSP00000020524","abundance":0.312,"rank":14877,"name":"Rhbdf1","annotation":"Inactive rhomboid protein 1; Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own."},{"id":"ENSMUSP00000149358","abundance":0.311,"rank":14878,"name":"Olfr1393","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149724","abundance":0.311,"rank":14879,"name":"Olfr10","annotation":"Olfactory receptor 10; Odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000148420","abundance":0.311,"rank":14880,"name":"Axdnd1","annotation":"Axonemal dynein light chain domain-containing protein 1."},{"id":"ENSMUSP00000042857","abundance":0.311,"rank":14881,"name":"Dnah3","annotation":"Dynein heavy chain 3, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)."},{"id":"ENSMUSP00000154836","abundance":0.311,"rank":14882,"name":"Csf2rb","annotation":"Cytokine receptor common subunit beta; High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor."},{"id":"ENSMUSP00000056681","abundance":0.311,"rank":14883,"name":"Catsperz","annotation":"Cation channel sperm-associated protein subunit zeta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum, maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9, associates with the CatSper channel pore and is required for the two- row structure of each single CatSper channel."},{"id":"ENSMUSP00000042889","abundance":0.311,"rank":14884,"name":"9130409I23Rik","annotation":"RIKEN cDNA 9130409I23 gene."},{"id":"ENSMUSP00000140049","abundance":0.311,"rank":14885,"name":"Birc2","annotation":"Baculoviral IAP repeat-containing protein 2; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target protein [...] "},{"id":"ENSMUSP00000129483","abundance":0.311,"rank":14886,"name":"Tent5d","annotation":"Terminal nucleotidyltransferase 5D."},{"id":"ENSMUSP00000132815","abundance":0.31,"rank":14887,"name":"Phlda1","annotation":"Pleckstrin homology-like domain family A member 1; Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR-induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation."},{"id":"ENSMUSP00000027587","abundance":0.31,"rank":14888,"name":"Ccnt2","annotation":"Cyclin-T2; Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy- terminal domain) of the large subunit of RNA polymerase II (RNAP II). The activity of this complex is regulated by binding with 7SK snRNA (By similarity). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 throug [...] "},{"id":"ENSMUSP00000072079","abundance":0.31,"rank":14889,"name":"Zfp329","annotation":"Zinc finger protein 329; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000068120","abundance":0.31,"rank":14890,"name":"Ghrhr","annotation":"Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family."},{"id":"ENSMUSP00000003044","abundance":0.31,"rank":14891,"name":"Pnkp","annotation":"Bifunctional polynucleotide phosphatase/kinase; Plays a key role in the repair of DNA damage, functioning as part of both the non-homologous end-joining (NHEJ) and base excision repair (BER) pathways. Through its two catalytic activities, PNK ensures that DNA termini are compatible with extension and ligation by either removing 3'-phosphates from, or by phosphorylating 5'-hydroxyl groups on, the ribose sugar of the DNA backbone."},{"id":"ENSMUSP00000048754","abundance":0.31,"rank":14892,"name":"Pih1h3b","annotation":"PIH1 domain-containing 3B."},{"id":"ENSMUSP00000081845","abundance":0.31,"rank":14893,"name":"Scn10a","annotation":"Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage- dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily."},{"id":"ENSMUSP00000054112","abundance":0.31,"rank":14894,"name":"Tgs1","annotation":"Trimethylguanosine synthase; Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation (By similarity); Belongs to the methyltransferase superfamily. Trimethylguanosine [...] "},{"id":"ENSMUSP00000047860","abundance":0.31,"rank":14895,"name":"Fam151a","annotation":"Protein FAM151A."},{"id":"ENSMUSP00000019616","abundance":0.31,"rank":14896,"name":"Icam5","annotation":"Intercellular adhesion molecule 5; ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2); Belongs to the immunoglobulin superfamily. ICAM family."},{"id":"ENSMUSP00000109245","abundance":0.31,"rank":14897,"name":"Pcnx3","annotation":"Pecanex-like protein 3; Belongs to the pecanex family."},{"id":"ENSMUSP00000151002","abundance":0.31,"rank":14898,"name":"Il18","annotation":"Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family."},{"id":"ENSMUSP00000113851","abundance":0.31,"rank":14899,"name":"Bcl3","annotation":"B-cell lymphoma 3 protein homolog; Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit (By similarity). In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation."},{"id":"ENSMUSP00000068321","abundance":0.31,"rank":14900,"name":"Kbtbd11","annotation":"Kelch repeat and BTB domain-containing protein 11."},{"id":"ENSMUSP00000055747","abundance":0.309,"rank":14901,"name":"Nod1","annotation":"Nucleotide-binding oligomerization domain-containing protein 1; Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Recruits NLRP10 to the cell membrane following bacterial infection (By similarity)."},{"id":"ENSMUSP00000101482","abundance":0.309,"rank":14902,"name":"Nipal3","annotation":"NIPA-like protein 3."},{"id":"ENSMUSP00000032406","abundance":0.309,"rank":14903,"name":"Ogg1","annotation":"DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion; Belongs to the type-1 OGG1 family."},{"id":"ENSMUSP00000148155","abundance":0.309,"rank":14904,"name":"Gm17655","annotation":"Predicted gene, 17655."},{"id":"ENSMUSP00000037180","abundance":0.309,"rank":14905,"name":"Prex1","annotation":"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils (By similarity)."},{"id":"ENSMUSP00000030191","abundance":0.308,"rank":14906,"name":"Npr2","annotation":"Atrial natriuretic peptide receptor 2; Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth."},{"id":"ENSMUSP00000026062","abundance":0.308,"rank":14907,"name":"Casp7","annotation":"Caspase-7 subunit p11; Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Overexpression promotes programmed cell death (By similarity)."},{"id":"ENSMUSP00000079592","abundance":0.308,"rank":14908,"name":"Zbtb24","annotation":"Zinc finger and BTB domain-containing protein 24; May be involved in BMP2-induced transcription."},{"id":"ENSMUSP00000124065","abundance":0.308,"rank":14909,"name":"Vmn2r89","annotation":"Putative pheromone receptor."},{"id":"ENSMUSP00000043552","abundance":0.308,"rank":14910,"name":"Taar9","annotation":"Trace amine-associated receptor 9; Orphan olfactory receptor specific for trace amines. Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000028831","abundance":0.307,"rank":14911,"name":"Mcm8","annotation":"DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross- links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication [...] "},{"id":"ENSMUSP00000029441","abundance":0.307,"rank":14912,"name":"Syt10","annotation":"Synaptotagmin-10; Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)- dependent synaptic vesicle exocytosis. Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity)."},{"id":"ENSMUSP00000098812","abundance":0.307,"rank":14913,"name":"Ccdc142","annotation":"Coiled-coil domain-containing protein 142."},{"id":"ENSMUSP00000035472","abundance":0.307,"rank":14914,"name":"Gjd4","annotation":"Gap junction delta-4 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell."},{"id":"ENSMUSP00000151487","abundance":0.307,"rank":14915,"name":"Olfr543","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000013949","abundance":0.307,"rank":14916,"name":"Birc3","annotation":"Baculoviral IAP repeat-containing protein 3; Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non- canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins [...] "},{"id":"ENSMUSP00000032489","abundance":0.307,"rank":14917,"name":"Ltbr","annotation":"Tumor necrosis factor receptor superfamily member 3; Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs (By similarity)."},{"id":"ENSMUSP00000076844","abundance":0.306,"rank":14918,"name":"Atp10b","annotation":"Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily."},{"id":"ENSMUSP00000141020","abundance":0.306,"rank":14919,"name":"Smok3c","annotation":"Sperm motility kinase 3C."},{"id":"ENSMUSP00000096659","abundance":0.306,"rank":14920,"name":"Gcnt7","annotation":"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 7; Glycosyltransferase; Belongs to the glycosyltransferase 14 family."},{"id":"ENSMUSP00000024595","abundance":0.306,"rank":14921,"name":"Slc22a3","annotation":"Solute carrier family 22 member 3; Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family."},{"id":"ENSMUSP00000124342","abundance":0.306,"rank":14922,"name":"Vmn2r25","annotation":"Vomeronasal 2, receptor 25."},{"id":"ENSMUSP00000022784","abundance":0.306,"rank":14923,"name":"Haus4","annotation":"HAUS augmin-like complex subunit 4; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex."},{"id":"ENSMUSP00000035202","abundance":0.306,"rank":14924,"name":"Mon1a","annotation":"Vacuolar fusion protein MON1 homolog A; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes. Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (By similarity)."},{"id":"ENSMUSP00000128121","abundance":0.306,"rank":14925,"name":"Abca7","annotation":"ATP-binding cassette sub-family A member 7; Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation. P [...] "},{"id":"ENSMUSP00000072397","abundance":0.306,"rank":14926,"name":"Ntng1","annotation":"Netrin-G1; Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites."},{"id":"ENSMUSP00000039980","abundance":0.306,"rank":14927,"name":"Hykk","annotation":"Hydroxylysine kinase; Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L- lysine; Belongs to the aminoglycoside phosphotransferase family."},{"id":"ENSMUSP00000015049","abundance":0.305,"rank":14928,"name":"Dnajb9","annotation":"DnaJ homolog subfamily B member 9; Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also invol [...] "},{"id":"ENSMUSP00000148627","abundance":0.305,"rank":14929,"name":"Adh6b","annotation":"Alcohol dehydrogenase 6B (class V)."},{"id":"ENSMUSP00000026378","abundance":0.305,"rank":14930,"name":"Padi1","annotation":"Protein-arginine deiminase type-1; Catalyzes the deimination of arginine residues of proteins. Belongs to the protein arginine deiminase family."},{"id":"ENSMUSP00000042575","abundance":0.305,"rank":14931,"name":"Trhr2","annotation":"Thyrotropin-releasing hormone receptor 2; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000026068","abundance":0.305,"rank":14932,"name":"Vwa2","annotation":"Von Willebrand factor A domain-containing protein 2."},{"id":"ENSMUSP00000066214","abundance":0.305,"rank":14933,"name":"Spink5","annotation":"Serine peptidase inhibitor, Kazal type 5."},{"id":"ENSMUSP00000151167","abundance":0.305,"rank":14934,"name":"Olfr502","annotation":"Olfactory receptor 502; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000058254","abundance":0.305,"rank":14935,"name":"Nxph3","annotation":"Neurexophilin-3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins; Belongs to the neurexophilin family."},{"id":"ENSMUSP00000028351","abundance":0.305,"rank":14936,"name":"Dph7","annotation":"Diphthine methyltransferase; Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2)."},{"id":"ENSMUSP00000001706","abundance":0.305,"rank":14937,"name":"Hoxc9","annotation":"Homeobox protein Hox-C9; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis."},{"id":"ENSMUSP00000079730","abundance":0.304,"rank":14938,"name":"Nxf3","annotation":"Nuclear RNA export factor 3."},{"id":"ENSMUSP00000133065","abundance":0.304,"rank":14939,"name":"Kcnn4","annotation":"Intermediate conductance calcium-activated potassium channel protein 4; Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis (By similarity)."},{"id":"ENSMUSP00000112058","abundance":0.304,"rank":14940,"name":"Zfp628","annotation":"Zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3'."},{"id":"ENSMUSP00000116904","abundance":0.304,"rank":14941,"name":"A630010A05Rik","annotation":"RIKEN cDNA A630010A05 gene."},{"id":"ENSMUSP00000084361","abundance":0.304,"rank":14942,"name":"Speg","annotation":"Striated muscle-specific serine/threonine-protein kinase; Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells."},{"id":"ENSMUSP00000078695","abundance":0.304,"rank":14943,"name":"Gm5591","annotation":"Predicted gene 5591."},{"id":"ENSMUSP00000025046","abundance":0.304,"rank":14944,"name":"Ip6k3","annotation":"Inositol hexakisphosphate kinase 3; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity)."},{"id":"ENSMUSP00000023452","abundance":0.304,"rank":14945,"name":"Ccdc116","annotation":"Coiled-coil domain-containing protein 116."},{"id":"ENSMUSP00000023176","abundance":0.304,"rank":14946,"name":"Zfp263","annotation":"Zinc finger protein 263."},{"id":"ENSMUSP00000064943","abundance":0.303,"rank":14947,"name":"Mlxip","annotation":"MLX-interacting protein; Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation."},{"id":"ENSMUSP00000034398","abundance":0.303,"rank":14948,"name":"Cep57","annotation":"Centrosomal protein of 57 kDa; Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2."},{"id":"ENSMUSP00000039361","abundance":0.302,"rank":14949,"name":"Dennd6a","annotation":"Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity)."},{"id":"ENSMUSP00000155932","abundance":0.302,"rank":14950,"name":"Gsc2","annotation":"Homeobox protein goosecoid-2; May have a role in development. May regulate its own transcription. May bind the bicoid consensus sequence TAATCC; Belongs to the paired homeobox family. Bicoid subfamily."},{"id":"ENSMUSP00000002336","abundance":0.302,"rank":14951,"name":"Zim1","annotation":"Zinc finger, imprinted 1."},{"id":"ENSMUSP00000130864","abundance":0.302,"rank":14952,"name":"Ino80d","annotation":"INO80 complex subunit D; Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; Belongs to the INO80D family."},{"id":"ENSMUSP00000069723","abundance":0.302,"rank":14953,"name":"Apobec4","annotation":"Putative C->U-editing enzyme APOBEC-4; Putative C to U editing enzyme whose physiological substrate is not yet known."},{"id":"ENSMUSP00000024839","abundance":0.302,"rank":14954,"name":"Sik1","annotation":"Serine/threonine-protein kinase SIK1; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1 and CRTC2/TORC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium- sensing signaling network, prob [...] "},{"id":"ENSMUSP00000060827","abundance":0.302,"rank":14955,"name":"Glra2","annotation":"Glycine receptor subunit alpha-2; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down- regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA2 sub-subfamily."},{"id":"ENSMUSP00000052522","abundance":0.302,"rank":14956,"name":"Pik3r6","annotation":"Phosphoinositide 3-kinase regulatory subunit 6; Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G proteins than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS."},{"id":"ENSMUSP00000103442","abundance":0.301,"rank":14957,"name":"Ift80","annotation":"Intraflagellar transport protein 80 homolog; Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia."},{"id":"ENSMUSP00000025840","abundance":0.301,"rank":14958,"name":"Tesmin","annotation":"Tesmin; May have a role in spermatogenesis."},{"id":"ENSMUSP00000041878","abundance":0.301,"rank":14959,"name":"Mreg","annotation":"Melanoregulin; Probably functions as cargo-recognition protein that couples cytoplasmic vesicles to the transport machinery. Plays a role in hair pigmentation, a process that involves shedding of melanosome-containing vesicles from melanocytes, followed by phagocytosis of the melanosome-containing vesicles by keratinocytes. Functions on melanosomes as receptor for RILP and the complex formed by RILP and DCTN1, and thereby contributes to retrograde melanosome transport from the cell periphery to the center. Overexpression causes accumulation of late endosomes and/or lysosomes at the mic [...] "},{"id":"ENSMUSP00000026677","abundance":0.301,"rank":14960,"name":"Nat1","annotation":"Arylamine N-acetyltransferase 1; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Isoniazid, 2-aminofluorene and anisidine are preferred substrates for NAT-1. No activity with p-aminobenzoic acid (PABA) nor SMZ."},{"id":"ENSMUSP00000025223","abundance":0.3,"rank":14961,"name":"Cyp21a1","annotation":"Steroid 21-hydroxylase; Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids."},{"id":"ENSMUSP00000124963","abundance":0.3,"rank":14962,"name":"Prkg2","annotation":"cGMP-dependent protein kinase 2; Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP- dependent translocation of CFTR in jejunum (By similarity). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 AND MAPK1/ERK2 in mechanical [...] "},{"id":"ENSMUSP00000082091","abundance":0.3,"rank":14963,"name":"Ip6k2","annotation":"Inositol hexakisphosphate kinase 2; Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) (By similarity). May play a role in the regulation of Na(+)-dependent phosphate cotransport, possibly via its role in diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) biosynthesis (By similarity)."},{"id":"ENSMUSP00000105629","abundance":0.3,"rank":14964,"name":"Zfp882","annotation":"Zinc finger protein 882."},{"id":"ENSMUSP00000156489","abundance":0.3,"rank":14965,"name":"Gm7072","annotation":"Predicted gene 7072."},{"id":"ENSMUSP00000027040","abundance":0.3,"rank":14966,"name":"Rb1cc1","annotation":"RB1-inducible coiled-coil protein 1; Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy. Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis. Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (B [...] "},{"id":"ENSMUSP00000097627","abundance":0.299,"rank":14967,"name":"Klhl41","annotation":"Kelch-like protein 41; Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells."},{"id":"ENSMUSP00000096170","abundance":0.299,"rank":14968,"name":"G430095P16Rik","annotation":"RIKEN cDNA G430095P16 gene."},{"id":"ENSMUSP00000148805","abundance":0.299,"rank":14969,"name":"Msantd4","annotation":"Myb/SANT-like DNA-binding domain-containing protein 4."},{"id":"ENSMUSP00000126749","abundance":0.299,"rank":14970,"name":"Tecpr2","annotation":"Tectonin beta-propeller repeat-containing 2."},{"id":"ENSMUSP00000057916","abundance":0.299,"rank":14971,"name":"Ntf5","annotation":"Neurotrophin-4; Could serve as a target-derived trophic factor for sensory and sympathetic neurons; Belongs to the NGF-beta family."},{"id":"ENSMUSP00000138575","abundance":0.299,"rank":14972,"name":"Plekha7","annotation":"Pleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (By similarity). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33."},{"id":"ENSMUSP00000099469","abundance":0.298,"rank":14973,"name":"Pex10","annotation":"Peroxisome biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes."},{"id":"ENSMUSP00000083049","abundance":0.298,"rank":14974,"name":"Smok3a","annotation":"Sperm motility kinase 3A; May play a role in sperm motility, especially in the regulation of flagellar function; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily."},{"id":"ENSMUSP00000098105","abundance":0.298,"rank":14975,"name":"Smok3b","annotation":"Sperm motility kinase 3B."},{"id":"ENSMUSP00000100621","abundance":0.298,"rank":14976,"name":"Fthl17d","annotation":"Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation."},{"id":"ENSMUSP00000094254","abundance":0.298,"rank":14977,"name":"Fthl17e","annotation":"Ferritin heavy polypeptide-like 17."},{"id":"ENSMUSP00000072297","abundance":0.298,"rank":14978,"name":"Oas1h","annotation":"2',5'-oligoadenylate synthetase-like 6."},{"id":"ENSMUSP00000020954","abundance":0.298,"rank":14979,"name":"Trappc12","annotation":"Trafficking protein particle complex subunit 12; Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage. Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores."},{"id":"ENSMUSP00000021494","abundance":0.298,"rank":14980,"name":"Ccdc175","annotation":"Coiled-coil domain-containing protein 175."},{"id":"ENSMUSP00000035512","abundance":0.298,"rank":14981,"name":"Arid4a","annotation":"AT-rich interactive domain-containing protein 4A; DNA-binding protein which modulates activity of several transcription factors including RB1 (retinoblastoma-associated protein) and AR (androgen receptor). May function as part of an mSin3A repressor complex (By similarity). Has no intrinsic transcriptional activity. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4B. Involved in spermatogenesis, together with ARID4B, where it acts as a transcriptional coacti [...] "},{"id":"ENSMUSP00000152387","abundance":0.298,"rank":14982,"name":"Mtrr","annotation":"Methionine synthase reductase; Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects."},{"id":"ENSMUSP00000146896","abundance":0.298,"rank":14983,"name":"Camsap3","annotation":"Calmodulin-regulated spectrin-associated protein 3; Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization. Specifically recognizes growing microtubule minus- ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization. Acts on free microtubule minus-ends that are not capped by microtubule- nucleating proteins or other factors and protects microtubule minus- ends from depolymerization. In addition, it also reduces the velocity of microtub [...] "},{"id":"ENSMUSP00000005976","abundance":0.298,"rank":14984,"name":"Tnfsf14","annotation":"Tumor necrosis factor ligand superfamily member 14, membrane form; Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells. Acts as a ligand for TNFRSF14/HVEM. Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (By similarity)."},{"id":"ENSMUSP00000150130","abundance":0.298,"rank":14985,"name":"Ankdd1a","annotation":"Ankyrin repeat and death domain-containing 1A."},{"id":"ENSMUSP00000099515","abundance":0.298,"rank":14986,"name":"5730455P16Rik","annotation":"Protein Njmu-R1; May have a role in spermatogenesis."},{"id":"ENSMUSP00000154022","abundance":0.297,"rank":14987,"name":"Cdh9","annotation":"Cadherin-9; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types."},{"id":"ENSMUSP00000032238","abundance":0.297,"rank":14988,"name":"Vmn2r26","annotation":"Vomeronasal type-2 receptor 26; Putative pheromone receptor."},{"id":"ENSMUSP00000066040","abundance":0.297,"rank":14989,"name":"Alas2","annotation":"5-aminolevulinate synthase, erythroid-specific, mitochondrial."},{"id":"ENSMUSP00000110233","abundance":0.297,"rank":14990,"name":"Gm609","annotation":"Predicted gene 609."},{"id":"ENSMUSP00000031554","abundance":0.297,"rank":14991,"name":"Tmem168","annotation":"Transmembrane protein 168."},{"id":"ENSMUSP00000002395","abundance":0.297,"rank":14992,"name":"Rec8","annotation":"Meiotic recombination protein REC8 homolog; Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II."},{"id":"ENSMUSP00000072296","abundance":0.296,"rank":14993,"name":"Vmn2r30","annotation":"Vomeronasal 2, receptor 30."},{"id":"ENSMUSP00000119345","abundance":0.296,"rank":14994,"name":"Nlk","annotation":"Serine/threonine-protein kinase NLK; Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhi [...] "},{"id":"ENSMUSP00000155487","abundance":0.296,"rank":14995,"name":"Phf20l1","annotation":"PHD finger protein 20-like protein 1."},{"id":"ENSMUSP00000029462","abundance":0.296,"rank":14996,"name":"Tbx15","annotation":"T-box transcription factor TBX15; Probable transcriptional regulator involved in the development of the skeleton of the limb, vertebral column and head. Acts by controlling the number of mesenchymal precursor cells and chondrocytes."},{"id":"ENSMUSP00000026225","abundance":0.296,"rank":14997,"name":"Sema4g","annotation":"Semaphorin-4G; Cell surface receptor for PLXNB2. May play a role in axon guidance; Belongs to the semaphorin family."},{"id":"ENSMUSP00000057607","abundance":0.296,"rank":14998,"name":"Otol1","annotation":"Otolin-1; Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear. Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure. Together with OC90, modulates calcite crystal morphology and growth kinetics ; Belongs to the OTOL1 family."},{"id":"ENSMUSP00000099874","abundance":0.296,"rank":14999,"name":"Garnl3","annotation":"GTPase-activating Rap/Ran-GAP domain-like protein 3."},{"id":"ENSMUSP00000132338","abundance":0.296,"rank":15000,"name":"Skor2","annotation":"SKI family transcriptional corepressor 2; Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity."},{"id":"ENSMUSP00000038925","abundance":0.295,"rank":15001,"name":"Elane","annotation":"Neutrophil elastase; Medullasin modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity). Capable of killing E.coli; probably digests outer membrane protein A (ompA) in E.coli ; Belongs to the peptidase S1 family. Elastase subfamily."},{"id":"ENSMUSP00000093732","abundance":0.295,"rank":15002,"name":"Klrg2","annotation":"Killer cell lectin-like receptor subfamily G member 2."},{"id":"ENSMUSP00000127665","abundance":0.295,"rank":15003,"name":"Pih1d3","annotation":"Protein PIH1D3; Plays a role in cytoplasmic pre-assembly of axonemal dynein."},{"id":"ENSMUSP00000003597","abundance":0.295,"rank":15004,"name":"Psg18","annotation":"Pregnancy-specific glycoprotein 18."},{"id":"ENSMUSP00000039107","abundance":0.295,"rank":15005,"name":"Ccr3","annotation":"Probable C-C chemokine receptor type 3; Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1."},{"id":"ENSMUSP00000101399","abundance":0.295,"rank":15006,"name":"Gm13083","annotation":"Predicted gene 13083."},{"id":"ENSMUSP00000052826","abundance":0.295,"rank":15007,"name":"Fam78a","annotation":"Protein FAM78A; Belongs to the FAM78 family."},{"id":"ENSMUSP00000152240","abundance":0.295,"rank":15008,"name":"Nin","annotation":"Ninein; Centrosomal protein required for the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor (By similarity). May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules (By similarity). Required for centriole organization and microtubule anchoring at the mother centriole (By similarity)."},{"id":"ENSMUSP00000049404","abundance":0.295,"rank":15009,"name":"Znfx1","annotation":"NFX1-type zinc finger-containing protein 1."},{"id":"ENSMUSP00000081891","abundance":0.295,"rank":15010,"name":"Chrna10","annotation":"Cholinergic receptor, nicotinic, alpha polypeptide 10."},{"id":"ENSMUSP00000033149","abundance":0.294,"rank":15011,"name":"Cpxm2","annotation":"Inactive carboxypeptidase-like protein X2; May be involved in cell-cell interactions."},{"id":"ENSMUSP00000044998","abundance":0.294,"rank":15012,"name":"Rptn","annotation":"Repetin; Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein; Belongs to the S100-fused protein family."},{"id":"ENSMUSP00000020163","abundance":0.294,"rank":15013,"name":"Nedd1","annotation":"Protein NEDD1; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle (By similarity). May play an important role during the embryonic development and differentiation of the central nervous system."},{"id":"ENSMUSP00000150794","abundance":0.294,"rank":15014,"name":"Olfr823","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000036674","abundance":0.293,"rank":15015,"name":"Dock5","annotation":"Dedicator of cytokinesis protein 5; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (By similarity)."},{"id":"ENSMUSP00000139977","abundance":0.293,"rank":15016,"name":"Vmn1r205","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000094793","abundance":0.293,"rank":15017,"name":"Fthl17f","annotation":"Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation."},{"id":"ENSMUSP00000078047","abundance":0.293,"rank":15018,"name":"Hhip","annotation":"Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2; Belongs to the HHIP family."},{"id":"ENSMUSP00000027277","abundance":0.293,"rank":15019,"name":"Stat4","annotation":"Signal transducer and activator of transcription 4; Carries out a dual function: signal transduction and activation of transcription."},{"id":"ENSMUSP00000081690","abundance":0.293,"rank":15020,"name":"Abca14","annotation":"ATP-binding cassette, sub-family A (ABC1), member 14."},{"id":"ENSMUSP00000021813","abundance":0.293,"rank":15021,"name":"Barx1","annotation":"Homeobox protein BarH-like 1; Transcription factor, which is involved in craniofacial development, in odontogenesis and in stomach organogenesis. May have a role in the differentiation of molars from incisors. Plays a role in suppressing endodermal Wnt activity. Binds to a regulatory module of the NCAM promoter; Belongs to the BAR homeobox family."},{"id":"ENSMUSP00000025004","abundance":0.293,"rank":15022,"name":"Adgre4","annotation":"Adhesion G protein-coupled receptor E4; May mediate the cellular interaction between myeloid cells and B-cells; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily."},{"id":"ENSMUSP00000056212","abundance":0.293,"rank":15023,"name":"Klhdc9","annotation":"Kelch domain-containing protein 9."},{"id":"ENSMUSP00000025288","abundance":0.292,"rank":15024,"name":"Zfp521","annotation":"Zinc finger protein 521; Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes."},{"id":"ENSMUSP00000097281","abundance":0.292,"rank":15025,"name":"Accsl","annotation":"Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2."},{"id":"ENSMUSP00000044521","abundance":0.292,"rank":15026,"name":"Gucy2f","annotation":"Retinal guanylyl cyclase 2; Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (By similarity). Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane."},{"id":"ENSMUSP00000063887","abundance":0.292,"rank":15027,"name":"Slc24a5","annotation":"Sodium/potassium/calcium exchanger 5; Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Predominant sodium- Calcium exchanger in melanocytes. Probably transports 1 Ca(2+) and 1 K(+) to the melanosome in exchange for 4 cytoplasmic Na(+) (By similarity)."},{"id":"ENSMUSP00000045343","abundance":0.292,"rank":15028,"name":"AAdacl4fm3","annotation":"AADACL4 family member 3."},{"id":"ENSMUSP00000070560","abundance":0.292,"rank":15029,"name":"Tll1","annotation":"Tolloid-like protein 1; Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development, especially heart development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis."},{"id":"ENSMUSP00000004949","abundance":0.292,"rank":15030,"name":"Traf6","annotation":"TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation (By similarity). Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter p [...] "},{"id":"ENSMUSP00000131128","abundance":0.291,"rank":15031,"name":"Vmn2r118","annotation":"Vomeronasal 2, receptor 118."},{"id":"ENSMUSP00000030898","abundance":0.291,"rank":15032,"name":"Arhgef16","annotation":"Rho guanine nucleotide exchange factor 16; Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 (By similarity)."},{"id":"ENSMUSP00000061517","abundance":0.291,"rank":15033,"name":"Gal3st3","annotation":"Galactose-3-O-sulfotransferase 3; Transfers a sulfate to position 3 of non-reducing beta- galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc (By similarity); Belongs to the galactose-3-O-sulfotransferase family."},{"id":"ENSMUSP00000056787","abundance":0.291,"rank":15034,"name":"Ankrd34c","annotation":"Ankyrin repeat domain-containing protein 34C; Belongs to the ANKRD34 family."},{"id":"ENSMUSP00000136055","abundance":0.291,"rank":15035,"name":"Stard9","annotation":"StAR-related lipid transfer protein 9; Microtubule-dependent motor protein required for spindle pole assembly during mitosis. Required to stabilize the pericentriolar material (PCM) (By similarity)."},{"id":"ENSMUSP00000140487","abundance":0.291,"rank":15036,"name":"Gsdmc2","annotation":"Gasdermin-C2; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family."},{"id":"ENSMUSP00000096040","abundance":0.291,"rank":15037,"name":"Col6a6","annotation":"Collagen alpha-6(VI) chain; Collagen VI acts as a cell-binding protein; Belongs to the type VI collagen family."},{"id":"ENSMUSP00000070488","abundance":0.291,"rank":15038,"name":"Tbc1d30","annotation":"TBC1 domain family member 30; GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro (By similarity)."},{"id":"ENSMUSP00000051871","abundance":0.291,"rank":15039,"name":"Pcare","annotation":"Photoreceptor cilium actin regulator; Plays an essential role for normal photoreceptor cell maintenance and vision."},{"id":"ENSMUSP00000014072","abundance":0.29,"rank":15040,"name":"Thap8","annotation":"THAP domain-containing 8."},{"id":"ENSMUSP00000027940","abundance":0.29,"rank":15041,"name":"Pacc1","annotation":"Proton-activated chloride channel; Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH. Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling."},{"id":"ENSMUSP00000047640","abundance":0.29,"rank":15042,"name":"Ptchd4","annotation":"Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4- expressing cells; Belongs to the patched family."},{"id":"ENSMUSP00000148739","abundance":0.29,"rank":15043,"name":"Rfxank","annotation":"DNA-binding protein RFXANK; Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator/CIITA. May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters (By similarity). May also potentiate the activation of RAF1."},{"id":"ENSMUSP00000038346","abundance":0.29,"rank":15044,"name":"Mansc1","annotation":"MANSC domain-containing protein 1."},{"id":"ENSMUSP00000023953","abundance":0.29,"rank":15045,"name":"Ceacam14","annotation":"Carcinoembryonic antigen-related cell adhesion molecule 14."},{"id":"ENSMUSP00000108732","abundance":0.29,"rank":15046,"name":"Kir3dl2","annotation":"Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2."},{"id":"ENSMUSP00000099430","abundance":0.29,"rank":15047,"name":"Ikzf3","annotation":"Zinc finger protein Aiolos; Transcription factor that plays an important role in the regulation of lymphocyte differentiation. Binds to GGGAA. Plays an essential role in regulation of B-cell differentiation, proliferation and maturation to an effector state. Involved in regulating BCL2 expression and controlling apoptosis in T-cells in an IL2-dependent manner; Belongs to the Ikaros C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000004614","abundance":0.29,"rank":15048,"name":"Zfp110","annotation":"Neurotrophin receptor-interacting factor 1; Transcription regulator involved in NGFR/p75(NTR)-mediated apoptosis. Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis. Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons. May also regulate expression of neuronal cholesterol biosynthesis genes. Probably acts a [...] "},{"id":"ENSMUSP00000037574","abundance":0.29,"rank":15049,"name":"Trpc4ap","annotation":"Short transient receptor potential channel 4-associated protein; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRUSS) complex specifically mediates the polyubiquitination and subsequent degradation of MYC (By similarity). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to [...] "},{"id":"ENSMUSP00000047609","abundance":0.289,"rank":15050,"name":"Pcdha12","annotation":"Protocadherin alpha 12."},{"id":"ENSMUSP00000081122","abundance":0.289,"rank":15051,"name":"Plch1","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by calcium-activated phosphatidylinositol-specific phospholipase C enzymes."},{"id":"ENSMUSP00000090850","abundance":0.289,"rank":15052,"name":"Atxn1l","annotation":"Ataxin-1-like; Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ- mediated repression (By similarity). Can suppress the cytotoxicity of ATXN1 in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development."},{"id":"ENSMUSP00000126933","abundance":0.289,"rank":15053,"name":"Serpina16","annotation":"Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 16; Belongs to the serpin family."},{"id":"ENSMUSP00000016498","abundance":0.288,"rank":15054,"name":"Srms","annotation":"Tyrosine-protein kinase Srms; Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent."},{"id":"ENSMUSP00000021794","abundance":0.288,"rank":15055,"name":"Nedd9","annotation":"Enhancer of filamentation 1; Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphoryla [...] "},{"id":"ENSMUSP00000121321","abundance":0.288,"rank":15056,"name":"Lipo4","annotation":"Lipase; Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000003135","abundance":0.288,"rank":15057,"name":"Elf3","annotation":"ETS-related transcription factor Elf-3; Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter (By similarity). Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity (By similarity). Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. Ma [...] "},{"id":"ENSMUSP00000132457","abundance":0.288,"rank":15058,"name":"Vmn2r36","annotation":"Vomeronasal 2, receptor 36."},{"id":"ENSMUSP00000084936","abundance":0.288,"rank":15059,"name":"Zfp763","annotation":"Zinc finger protein 763."},{"id":"ENSMUSP00000113090","abundance":0.288,"rank":15060,"name":"Tmem132c","annotation":"Transmembrane protein 132C."},{"id":"ENSMUSP00000027172","abundance":0.288,"rank":15061,"name":"Ica1l","annotation":"Islet cell autoantigen 1-like protein."},{"id":"ENSMUSP00000144092","abundance":0.288,"rank":15062,"name":"Med13l","annotation":"Mediator of RNA polymerase II transcription subunit 13-like; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may sp [...] "},{"id":"ENSMUSP00000025986","abundance":0.287,"rank":15063,"name":"Tll2","annotation":"Tolloid-like protein 2; Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis."},{"id":"ENSMUSP00000056254","abundance":0.287,"rank":15064,"name":"Map3k19","annotation":"Mitogen-activated protein kinase kinase kinase 19; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily."},{"id":"ENSMUSP00000061899","abundance":0.287,"rank":15065,"name":"Zbtb40","annotation":"Zinc finger and BTB domain-containing 40."},{"id":"ENSMUSP00000020662","abundance":0.287,"rank":15066,"name":"Kremen1","annotation":"Kremen protein 1; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. In the absence of DKK1, potentiates Wnt-beta-catenin signaling by maintaining LRP5 or LRP6 at the cell membrane (By similarity). Can trigger apoptosis in a Wnt- independent manner and this apoptotic activity is inhibited upon binding of the ligand DKK1. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning and can also negatively regulate bone formation. Mod [...] "},{"id":"ENSMUSP00000137420","abundance":0.287,"rank":15067,"name":"Alkal1","annotation":"ALK and LTK ligand 1; Ligand for receptor tyrosine kinase LTK and perhaps receptor tyrosine kinase ALK; activation of ALK is reported conflictingly. Belongs to the ALKAL family."},{"id":"ENSMUSP00000035635","abundance":0.287,"rank":15068,"name":"5530400C23Rik","annotation":"RIKEN cDNA 5530400C23 gene."},{"id":"ENSMUSP00000031750","abundance":0.287,"rank":15069,"name":"Arhgef5","annotation":"Rho guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor which activates Rho GTPases. Strongly activates RHOA. Also strongly activates RHOB, weakly activates RHOC and RHOG and shows no effect on RHOD, RHOV, RHOQ or RAC1. Involved in regulation of cell shape and actin cytoskeletal organization. Plays a role in actin organization by generating a loss of actin stress fibers and the formation of membrane ruffles and filopodia (By similarity). Required for SRC-induced podosome formation. Involved in positive regulation of immature dendritic cell migration."},{"id":"ENSMUSP00000102417","abundance":0.287,"rank":15070,"name":"Gm5901","annotation":"Predicted gene 5901."},{"id":"ENSMUSP00000074735","abundance":0.286,"rank":15071,"name":"Zfp874a","annotation":"Regulator of sex-limitation candidate 15."},{"id":"ENSMUSP00000025875","abundance":0.286,"rank":15072,"name":"Slc1a1","annotation":"Excitatory amino acid transporter 3; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays an important role in L-glutamate and L-aspar [...] "},{"id":"ENSMUSP00000038188","abundance":0.286,"rank":15073,"name":"Cenpt","annotation":"Centromere protein T; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3- containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and [...] "},{"id":"ENSMUSP00000067837","abundance":0.286,"rank":15074,"name":"Bpi","annotation":"Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family."},{"id":"ENSMUSP00000015594","abundance":0.286,"rank":15075,"name":"Mcpt8","annotation":"Mast cell protease 8."},{"id":"ENSMUSP00000077535","abundance":0.286,"rank":15076,"name":"Trim31","annotation":"E3 ubiquitin-protein ligase TRIM31; May have E3 ubiquitin-protein ligase activity (By similarity). Regulator of Src-induced anchorage independent cell growth."},{"id":"ENSMUSP00000121562","abundance":0.286,"rank":15077,"name":"Dnmt3l","annotation":"DNA (cytosine-5)-methyltransferase 3-like; Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context. Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain. Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or a [...] "},{"id":"ENSMUSP00000144243","abundance":0.286,"rank":15078,"name":"Gm42742","annotation":"PAXIP1-associated glutamate-rich protein 1A; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated  [...] "},{"id":"ENSMUSP00000144469","abundance":0.286,"rank":15079,"name":"Pagr1a","annotation":"PAXIP1 associated glutamate rich protein 1A."},{"id":"ENSMUSP00000020383","abundance":0.286,"rank":15080,"name":"Atp8b3","annotation":"Phospholipid-transporting ATPase IK; P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida; Belon [...] "},{"id":"ENSMUSP00000091745","abundance":0.286,"rank":15081,"name":"Meikin","annotation":"Meiosis-specific kinetochore protein; Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase- mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin- dependent protection [...] "},{"id":"ENSMUSP00000122395","abundance":0.286,"rank":15082,"name":"Asb7","annotation":"Ankyrin repeat and SOCS box protein 7; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins; Belongs to the ankyrin SOCS box (ASB) family."},{"id":"ENSMUSP00000060424","abundance":0.286,"rank":15083,"name":"Dbx2","annotation":"Developing brain homeobox 2."},{"id":"ENSMUSP00000088508","abundance":0.286,"rank":15084,"name":"Fcrls","annotation":"Fc receptor-like S, scavenger receptor."},{"id":"ENSMUSP00000074563","abundance":0.285,"rank":15085,"name":"Kcnh7","annotation":"Potassium voltage-gated channel subfamily H member 7; Pore-forming (alpha) subunit of voltage-gated potassium channel (By similarity). Channel properties may be modulated by cAMP and subunit assembly; Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.3/KCNH7 sub-subfamily."},{"id":"ENSMUSP00000074922","abundance":0.285,"rank":15086,"name":"Cav3","annotation":"Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity); Belongs to the caveolin family."},{"id":"ENSMUSP00000081764","abundance":0.285,"rank":15087,"name":"Fyco1","annotation":"FYVE and coiled-coil domain-containing protein 1; May mediate microtubule plus end-directed vesicle transport."},{"id":"ENSMUSP00000095939","abundance":0.285,"rank":15088,"name":"Ankrd11","annotation":"Ankyrin repeat domain-containing protein 11; Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells. May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (By similarity). Has a role in proliferation and development of cortical neural precursors. May also regulate bone homeostasis."},{"id":"ENSMUSP00000153308","abundance":0.284,"rank":15089,"name":"Dok3","annotation":"Docking protein 3; DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function."},{"id":"ENSMUSP00000129379","abundance":0.284,"rank":15090,"name":"Slc6a17","annotation":"Sodium-dependent neutral amino acid transporter SLC6A17; Functions as a sodium-dependent vesicular transporter selective for proline, glycine, leucine and alanine. In contrast to other members of this neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A17 subfamily."},{"id":"ENSMUSP00000056782","abundance":0.284,"rank":15091,"name":"1110032F04Rik","annotation":"Uncharacterized membrane protein C3orf80 homolog."},{"id":"ENSMUSP00000153809","abundance":0.284,"rank":15092,"name":"Gm30083","annotation":"Predicted gene, 30083."},{"id":"ENSMUSP00000108729","abundance":0.284,"rank":15093,"name":"Kir3dl1","annotation":"Killer cell immunoglobulin-like receptor 3DL1; Receptor on natural killer (NK) cells. Inhibits the activity of NK cells thus preventing cell lysis; Belongs to the immunoglobulin superfamily."},{"id":"ENSMUSP00000135696","abundance":0.284,"rank":15094,"name":"9930021J03Rik","annotation":"RIKEN cDNA 9930021J03 gene."},{"id":"ENSMUSP00000067897","abundance":0.284,"rank":15095,"name":"Rxfp2","annotation":"Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000092067","abundance":0.284,"rank":15096,"name":"Vmn2r121","annotation":"Vomeronasal 2, receptor 121."},{"id":"ENSMUSP00000109152","abundance":0.284,"rank":15097,"name":"Mogat1","annotation":"2-acylglycerol O-acyltransferase 1; Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine."},{"id":"ENSMUSP00000022786","abundance":0.283,"rank":15098,"name":"4931414P19Rik","annotation":"Uncharacterized protein C14orf93 homolog."},{"id":"ENSMUSP00000095380","abundance":0.283,"rank":15099,"name":"Klhl21","annotation":"Kelch-like protein 21; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome (By similarity)."},{"id":"ENSMUSP00000092286","abundance":0.283,"rank":15100,"name":"Rbm44","annotation":"RNA-binding protein 44; Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility."},{"id":"ENSMUSP00000017288","abundance":0.283,"rank":15101,"name":"Rnd3","annotation":"Rho-related GTP-binding protein RhoE; Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins."},{"id":"ENSMUSP00000044418","abundance":0.283,"rank":15102,"name":"Spns2","annotation":"Protein spinster homolog 2; Acts a a crucial lysosphingolipid sphingosine 1-phosphate (S1P) transporter involved in S1P secretion and function. S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system. Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking."},{"id":"ENSMUSP00000021030","abundance":0.283,"rank":15103,"name":"Mettl2","annotation":"tRNA N(3)-methylcytidine methyltransferase METTL2; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU)."},{"id":"ENSMUSP00000032491","abundance":0.283,"rank":15104,"name":"Tnfrsf1a","annotation":"Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity)."},{"id":"ENSMUSP00000132351","abundance":0.282,"rank":15105,"name":"Cic","annotation":"Protein capicua homolog; Transcriptional repressor which plays a role in development of the central nervous system (CNS). In concert with ATXN1 and ATXN1L, involved in brain development."},{"id":"ENSMUSP00000150689","abundance":0.282,"rank":15106,"name":"Olfr495","annotation":"Olfactory receptor 495; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000025681","abundance":0.282,"rank":15107,"name":"Cdc42bpg","annotation":"Serine/threonine-protein kinase MRCK gamma; May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity)."},{"id":"ENSMUSP00000080716","abundance":0.282,"rank":15108,"name":"Erbb3","annotation":"Receptor tyrosine-protein kinase erbB-3; Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation."},{"id":"ENSMUSP00000051546","abundance":0.282,"rank":15109,"name":"Lrfn5","annotation":"Leucine-rich repeat and fibronectin type-III domain-containing protein 5; Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity)."},{"id":"ENSMUSP00000145176","abundance":0.282,"rank":15110,"name":"Cntn3","annotation":"Contactin-3; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity); Belongs to the immunoglobulin superfamily. Contactin family."},{"id":"ENSMUSP00000066050","abundance":0.282,"rank":15111,"name":"Epm2a","annotation":"Laforin; Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro). Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohy [...] "},{"id":"ENSMUSP00000142325","abundance":0.281,"rank":15112,"name":"Klhdc8b","annotation":"Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells."},{"id":"ENSMUSP00000103762","abundance":0.281,"rank":15113,"name":"C9orf72","annotation":"Guanine nucleotide exchange C9orf72 homolog; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (By similarity). The C9orf72-SMCR8 complex also acts as a regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and modulating its protein kin [...] "},{"id":"ENSMUSP00000034243","abundance":0.281,"rank":15114,"name":"Mmp15","annotation":"Matrix metalloproteinase-15; Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A; Belongs to the peptidase M10A family."},{"id":"ENSMUSP00000055079","abundance":0.281,"rank":15115,"name":"Fam71b","annotation":"Protein FAM71B; May be involved in RNA biogenesis."},{"id":"ENSMUSP00000131503","abundance":0.281,"rank":15116,"name":"Cyp11b2","annotation":"Cytochrome P450 11B2, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone. Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21- hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-pro [...] "},{"id":"ENSMUSP00000155530","abundance":0.281,"rank":15117,"name":"Socs1","annotation":"Suppressor of cytokine signaling 1; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an [...] "},{"id":"ENSMUSP00000101182","abundance":0.281,"rank":15118,"name":"Phactr2","annotation":"Phosphatase and actin regulator."},{"id":"ENSMUSP00000100600","abundance":0.281,"rank":15119,"name":"Chml","annotation":"Rab proteins geranylgeranyltransferase component A 2; Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family (By similarity)."},{"id":"ENSMUSP00000010201","abundance":0.281,"rank":15120,"name":"Nprl2","annotation":"GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway; Belongs to the NPR2 family."},{"id":"ENSMUSP00000138008","abundance":0.281,"rank":15121,"name":"Tdpoz1","annotation":"TD and POZ domain-containing protein 1."},{"id":"ENSMUSP00000141802","abundance":0.281,"rank":15122,"name":"Gm9117","annotation":"Predicted pseudogene 9117."},{"id":"ENSMUSP00000138015","abundance":0.281,"rank":15123,"name":"Tdpoz9","annotation":"TD and POZ domain-containing protein 1-like; Belongs to the Tdpoz family."},{"id":"ENSMUSP00000046877","abundance":0.281,"rank":15124,"name":"Tbc1d22b","annotation":"TBC1 domain family, member 22B."},{"id":"ENSMUSP00000021592","abundance":0.281,"rank":15125,"name":"Cdca7l","annotation":"Cell division cycle-associated 7-like protein; Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells (By similarity). Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1."},{"id":"ENSMUSP00000059095","abundance":0.28,"rank":15126,"name":"1810030O07Rik","annotation":"Uncharacterized protein CXorf38 homolog."},{"id":"ENSMUSP00000023682","abundance":0.28,"rank":15127,"name":"Donson","annotation":"Protein downstream neighbor of Son; Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability."},{"id":"ENSMUSP00000043145","abundance":0.28,"rank":15128,"name":"Ak7","annotation":"Adenylate kinase 7; Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function; In the C-terminal section; belongs to the dpy-30 family."},{"id":"ENSMUSP00000024708","abundance":0.28,"rank":15129,"name":"Tnfrsf21","annotation":"Tumor necrosis factor receptor superfamily member 21; Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP- beta which is further cleaved to release an N-terminal fra [...] "},{"id":"ENSMUSP00000075719","abundance":0.28,"rank":15130,"name":"Gm21994","annotation":"Predicted gene 21994."},{"id":"ENSMUSP00000153827","abundance":0.28,"rank":15131,"name":"Vmn1r73","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000087985","abundance":0.279,"rank":15132,"name":"Fam149b","annotation":"Protein FAM149B1."},{"id":"ENSMUSP00000136872","abundance":0.279,"rank":15133,"name":"Kbtbd13","annotation":"Kelch repeat and BTB domain-containing protein 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000032198","abundance":0.279,"rank":15134,"name":"Usp18","annotation":"Ubl carboxyl-terminal hydrolase 18; Involved in the regulation of inflammatory response to interferon type 1. Can efficiently cleave only ISG15 fusions including native ISG15 conjugates linked via isopeptide bonds. Necessary to maintain a critical cellular balance of ISG15-conjugated proteins in both healthy and stressed organisms; Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000021311","abundance":0.279,"rank":15135,"name":"Kif18b","annotation":"Kinesin-like protein KIF18B; In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules (By similarity)."},{"id":"ENSMUSP00000108127","abundance":0.279,"rank":15136,"name":"Lipo3","annotation":"Lipase; Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000098701","abundance":0.279,"rank":15137,"name":"Shroom2","annotation":"Protein Shroom2; May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution."},{"id":"ENSMUSP00000108769","abundance":0.279,"rank":15138,"name":"Gprasp1","annotation":"G-protein coupled receptor-associated sorting protein 1; Modulates lysosomal sorting and functional down-regulation of a variety of G-protein coupled receptors. Targets receptors for degradation in lysosomes via its interaction with BECN2."},{"id":"ENSMUSP00000041025","abundance":0.279,"rank":15139,"name":"Pkn3","annotation":"Serine/threonine-protein kinase N3; Contributes to invasiveness in malignant prostate cancer."},{"id":"ENSMUSP00000094553","abundance":0.278,"rank":15140,"name":"Vmn2r122","annotation":"Vomeronasal 2, receptor, 122."},{"id":"ENSMUSP00000109067","abundance":0.278,"rank":15141,"name":"Ccdc88b","annotation":"Coiled-coil domain-containing protein 88B; Acts as a positive regulator of T-cell maturation and inflammatory function. Required for several functions of T-cells in both the CD4(+) and the CD8(+) compartments and this includes expression of cell surface markers of activation, proliferation, and cytokine production in response to specific or non-specific stimulation and during the course of infection with the mouse malaria parasite Plasmodium berghei. Enhances NK cell cytotoxicity by positively regulating polarization of microtubule-organizing center (MTOC) to cytotoxic synapse, lytic g [...] "},{"id":"ENSMUSP00000153023","abundance":0.278,"rank":15142,"name":"Ccdc66","annotation":"Coiled-coil domain-containing protein 66; Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (By similarity). Plays a role in retina morphogenesis and/or homeostasis."},{"id":"ENSMUSP00000058887","abundance":0.278,"rank":15143,"name":"Gpr151","annotation":"G-protein coupled receptor 151 protein; Proton-sensing G-protein coupled receptor."},{"id":"ENSMUSP00000082777","abundance":0.278,"rank":15144,"name":"Flvcr1","annotation":"Feline leukemia virus subgroup C receptor-related protein 1; [Isoform 1]: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies [...] "},{"id":"ENSMUSP00000018383","abundance":0.278,"rank":15145,"name":"Zcchc10","annotation":"Zinc finger CCHC domain-containing protein 10."},{"id":"ENSMUSP00000130496","abundance":0.278,"rank":15146,"name":"Gcnt4","annotation":"Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 4; Glycosyltransferase that mediates core 2 O-glycan branching, an important step in mucin-type biosynthesis. Does not have core 4 O- glycan or I-branching enzyme activity."},{"id":"ENSMUSP00000137609","abundance":0.278,"rank":15147,"name":"Ttc28","annotation":"Tetratricopeptide repeat protein 28; During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody."},{"id":"ENSMUSP00000108117","abundance":0.278,"rank":15148,"name":"Crim1","annotation":"Cysteine-rich motor neuron 1 protein; May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (By similarity)."},{"id":"ENSMUSP00000034205","abundance":0.278,"rank":15149,"name":"Cenpn","annotation":"Centromere protein N; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes o [...] "},{"id":"ENSMUSP00000132508","abundance":0.278,"rank":15150,"name":"Zfp101","annotation":"Zinc finger protein 101."},{"id":"ENSMUSP00000023617","abundance":0.277,"rank":15151,"name":"Ildr1","annotation":"Immunoglobulin-like domain-containing receptor 1; Putative membrane receptor; Belongs to the immunoglobulin superfamily. LISCH7 family."},{"id":"ENSMUSP00000024882","abundance":0.277,"rank":15152,"name":"Ttc27","annotation":"Tetratricopeptide repeat protein 27."},{"id":"ENSMUSP00000047775","abundance":0.277,"rank":15153,"name":"Fsd2","annotation":"Fibronectin type III and SPRY domain-containing protein 2."},{"id":"ENSMUSP00000029183","abundance":0.277,"rank":15154,"name":"Fam83d","annotation":"Protein FAM83D; Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22."},{"id":"ENSMUSP00000027809","abundance":0.277,"rank":15155,"name":"Opn3","annotation":"Opsin-3; May play a role in encephalic photoreception; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily."},{"id":"ENSMUSP00000154405","abundance":0.277,"rank":15156,"name":"Vmn1r24","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000077107","abundance":0.277,"rank":15157,"name":"Ccdc102a","annotation":"Coiled-coil domain-containing protein 102A."},{"id":"ENSMUSP00000013262","abundance":0.277,"rank":15158,"name":"Zkscan17","annotation":"Zinc finger protein 496; DNA-binding transcription factor that can both act as an activator and a repressor; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000001080","abundance":0.276,"rank":15159,"name":"N4bp3","annotation":"NEDD4-binding protein 3; Plays a role in axon and dendrite arborization during cranial nerve development. May also be important for neural crest migration and early development of other anterior structures including eye, brain and cranial cartilage."},{"id":"ENSMUSP00000052202","abundance":0.276,"rank":15160,"name":"Frmd6","annotation":"FERM domain-containing protein 6."},{"id":"ENSMUSP00000038002","abundance":0.276,"rank":15161,"name":"Clba1","annotation":"Uncharacterized protein CLBA1."},{"id":"ENSMUSP00000143873","abundance":0.276,"rank":15162,"name":"Fbxo21","annotation":"F-box only protein 21; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000023566","abundance":0.276,"rank":15163,"name":"Tmprss15","annotation":"Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (By similarity)."},{"id":"ENSMUSP00000061046","abundance":0.276,"rank":15164,"name":"Insm2","annotation":"Insulinoma-associated protein 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons."},{"id":"ENSMUSP00000043586","abundance":0.276,"rank":15165,"name":"Tex45","annotation":"Testis-expressed 45."},{"id":"ENSMUSP00000084199","abundance":0.276,"rank":15166,"name":"Cdkl2","annotation":"Cyclin-dependent kinase-like 2; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily."},{"id":"ENSMUSP00000091374","abundance":0.276,"rank":15167,"name":"Zbtb16","annotation":"Zinc finger and BTB domain-containing 16."},{"id":"ENSMUSP00000082952","abundance":0.275,"rank":15168,"name":"Lefty2","annotation":"Left-right determination factor 2; Required for left-right asymmetry determination of organ systems in mammals; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000044918","abundance":0.275,"rank":15169,"name":"Inhbb","annotation":"Inhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000055304","abundance":0.275,"rank":15170,"name":"Kif13a","annotation":"Kinesin-like protein KIF13A; Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19 [...] "},{"id":"ENSMUSP00000020448","abundance":0.275,"rank":15171,"name":"Irak3","annotation":"Interleukin-1 receptor-associated kinase 3; Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily."},{"id":"ENSMUSP00000086792","abundance":0.275,"rank":15172,"name":"Ssxb3","annotation":"Synovial sarcoma, X member B, breakpoint 3."},{"id":"ENSMUSP00000109197","abundance":0.275,"rank":15173,"name":"Obsl1","annotation":"Obscurin-like protein 1; Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7- RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons (By similarity)."},{"id":"ENSMUSP00000158516","abundance":0.274,"rank":15174,"name":"Gm8978","annotation":"Lipase; Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000037788","abundance":0.274,"rank":15175,"name":"Cep72","annotation":"Centrosomal protein of 72 kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) (By similarity). Involved in centriole duplication. Required for CDK5RAP22, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localiza [...] "},{"id":"ENSMUSP00000059463","abundance":0.274,"rank":15176,"name":"Lrrc3b","annotation":"Leucine-rich repeat-containing protein 3B."},{"id":"ENSMUSP00000095249","abundance":0.274,"rank":15177,"name":"Hdac4","annotation":"Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Deacetylates HSPA1A and HSPA1A at 'Lys-77' leading to their preferential binding to co-ch [...] "},{"id":"ENSMUSP00000043281","abundance":0.274,"rank":15178,"name":"Dnah1","annotation":"Dynein heavy chain 1, axonemal; Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme (By similarity)."},{"id":"ENSMUSP00000036913","abundance":0.274,"rank":15179,"name":"Slc25a28","annotation":"Mitoferrin-2; Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (Probable); Belongs to the mitochondrial carrier (TC 2.A.29) family."},{"id":"ENSMUSP00000025338","abundance":0.274,"rank":15180,"name":"Gabbr1","annotation":"Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivate [...] "},{"id":"ENSMUSP00000073860","abundance":0.273,"rank":15181,"name":"Dipk1b","annotation":"Divergent protein kinase domain 1B."},{"id":"ENSMUSP00000027202","abundance":0.273,"rank":15182,"name":"Sgo2a","annotation":"Shugoshin 2; Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to t [...] "},{"id":"ENSMUSP00000148758","abundance":0.273,"rank":15183,"name":"Rnf212","annotation":"Probable E3 SUMO-protein ligase RNF212; SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with  [...] "},{"id":"ENSMUSP00000101408","abundance":0.273,"rank":15184,"name":"Rsc1a1","annotation":"Regulatory solute carrier protein family 1 member 1; Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity). Regulates the expression of SLC5A1 in a tissue-specific manner and is specifically involved in its regulation in the small intestine."},{"id":"ENSMUSP00000136018","abundance":0.273,"rank":15185,"name":"Ddi2","annotation":"DNA-damage inducible protein 2."},{"id":"ENSMUSP00000048260","abundance":0.273,"rank":15186,"name":"Tbc1d17","annotation":"TBC1 domain family member 17; Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS- 50; the function requires its catalytic activity, however, the involved Rab is not known (By similarity)."},{"id":"ENSMUSP00000037416","abundance":0.273,"rank":15187,"name":"Cacna1b","annotation":"Voltage-dependent N-type calcium channel subunit alpha-1B; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin- GVIA (AC P01522) (By similarity). They are however insen [...] "},{"id":"ENSMUSP00000113475","abundance":0.273,"rank":15188,"name":"Gm49333","annotation":"EEF1AKMT4-ECE2 readthrough transcript protein; Converts big endothelin-1 to endothelin-1. May also have methyltransferase activity (By similarity). May play a role in amyloid- beta processing ; In the C-terminal section; belongs to the peptidase M13 family."},{"id":"ENSMUSP00000105862","abundance":0.273,"rank":15189,"name":"Cage1","annotation":"Cancer-associated gene 1 protein homolog."},{"id":"ENSMUSP00000002413","abundance":0.273,"rank":15190,"name":"Tmem161a","annotation":"Transmembrane protein 161A; May play a role in protection against oxidative stress. Overexpression leads to reduced levels of oxidant-induced DNA damage and apoptosis (By similarity)."},{"id":"ENSMUSP00000096914","abundance":0.272,"rank":15191,"name":"Slx4ip","annotation":"Protein SLX4IP; Belongs to the SLX4IP family."},{"id":"ENSMUSP00000101040","abundance":0.272,"rank":15192,"name":"Trpm2","annotation":"Transient receptor potential cation channel subfamily M member 2; Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. Extracellular calcium passes through the channel and increases channel activity (By similarity). Also contributes to Ca(2+) release from intracellular stores in response to ADP-ribose [...] "},{"id":"ENSMUSP00000105313","abundance":0.272,"rank":15193,"name":"Rapgef5","annotation":"Rap guanine nucleotide exchange factor 5; Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (By similarity)."},{"id":"ENSMUSP00000095223","abundance":0.272,"rank":15194,"name":"Ecscr","annotation":"Endothelial cell-specific chemotaxis regulator; Regulates endothelial chemotaxis and tube formation (By similarity). Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2; Belongs to the ECSCR family."},{"id":"ENSMUSP00000102229","abundance":0.272,"rank":15195,"name":"Ttc39a","annotation":"Tetratricopeptide repeat protein 39A."},{"id":"ENSMUSP00000149077","abundance":0.272,"rank":15196,"name":"Pomgnt2","annotation":"Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein (By similarity). Involved in the biosynthesis of the phosphorylated O- mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N- acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins w [...] "},{"id":"ENSMUSP00000022566","abundance":0.271,"rank":15197,"name":"Spata13","annotation":"Spermatogenesis-associated protein 13; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression."},{"id":"ENSMUSP00000037619","abundance":0.271,"rank":15198,"name":"L3mbtl3","annotation":"Lethal(3)malignant brain tumor-like protein 3; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Required for normal maturation of myeloid progenitor cells."},{"id":"ENSMUSP00000043411","abundance":0.271,"rank":15199,"name":"Scaper","annotation":"S phase cyclin A-associated protein in the ER."},{"id":"ENSMUSP00000027706","abundance":0.271,"rank":15200,"name":"Lrrn2","annotation":"Leucine-rich repeat protein 2, neuronal."},{"id":"ENSMUSP00000004770","abundance":0.271,"rank":15201,"name":"Tyr","annotation":"Tyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. Belongs to the tyrosinase family."},{"id":"ENSMUSP00000086034","abundance":0.271,"rank":15202,"name":"Mybl1","annotation":"Myb-related protein A; Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism, such as PIWIL1. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity. Transcrip [...] "},{"id":"ENSMUSP00000049104","abundance":0.271,"rank":15203,"name":"Gbp7","annotation":"Guanylate-binding protein 7."},{"id":"ENSMUSP00000025903","abundance":0.27,"rank":15204,"name":"Rps6ka4","annotation":"Ribosomal protein S6 kinase alpha-4; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to T [...] "},{"id":"ENSMUSP00000034090","abundance":0.27,"rank":15205,"name":"Sall1","annotation":"Sal-like protein 1; Transcriptional repressor involved in organogenesis. Essential for ureteric bud invasion in kidney development. Homozygous deletion of SALL1 results in an incomplete ureteric bud outgrowth, a failure of tubule formation in the mesenchyme and an apoptosis of the mesenchyme; Belongs to the sal C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000021684","abundance":0.27,"rank":15206,"name":"Cyp46a1","annotation":"Cholesterol 24-hydroxylase; P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation. By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning. Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side c [...] "},{"id":"ENSMUSP00000109108","abundance":0.27,"rank":15207,"name":"Cysltr1","annotation":"Cysteinyl leukotriene receptor 1; Receptor for cysteinyl leukotrienes mediating constriction of the microvascular smooth muscle during an inflammatory response. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4."},{"id":"ENSMUSP00000001626","abundance":0.27,"rank":15208,"name":"Tnk1","annotation":"Non-receptor tyrosine-protein kinase TNK1; May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction (By similarity). Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway."},{"id":"ENSMUSP00000097172","abundance":0.27,"rank":15209,"name":"Gm5134","annotation":"Predicted gene 5134; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family."},{"id":"ENSMUSP00000039058","abundance":0.27,"rank":15210,"name":"Kcnt1","annotation":"Potassium channel subfamily T member 1; Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily."},{"id":"ENSMUSP00000056464","abundance":0.27,"rank":15211,"name":"Rnf112","annotation":"RING finger protein 112; E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-ind [...] "},{"id":"ENSMUSP00000046021","abundance":0.269,"rank":15212,"name":"Tmem108","annotation":"Transmembrane protein 108; Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF- dependent dendri [...] "},{"id":"ENSMUSP00000044435","abundance":0.269,"rank":15213,"name":"Slfn9","annotation":"Schlafen family member 9; Endoribonuclease that cleaves tRNAs and rRNAs. Belongs to the Schlafen family. Subgroup III subfamily."},{"id":"ENSMUSP00000044482","abundance":0.269,"rank":15214,"name":"Trak1","annotation":"Trafficking kinesin-binding protein 1; Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (By similarity). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (By similarity). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain- independent, anterograde transport of mitochondria (By similarity)."},{"id":"ENSMUSP00000139969","abundance":0.269,"rank":15215,"name":"Gm29289","annotation":"Predicted gene 29289."},{"id":"ENSMUSP00000044457","abundance":0.269,"rank":15216,"name":"Sdr42e1","annotation":"Short-chain dehydrogenase/reductase family 42E member 1."},{"id":"ENSMUSP00000154183","abundance":0.268,"rank":15217,"name":"Vmn1r36","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000079268","abundance":0.268,"rank":15218,"name":"Zfp251","annotation":"Zinc finger protein 251."},{"id":"ENSMUSP00000040420","abundance":0.268,"rank":15219,"name":"Rbm45","annotation":"RNA-binding protein 45; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development (By similarity)."},{"id":"ENSMUSP00000054745","abundance":0.268,"rank":15220,"name":"Plekhf2","annotation":"Pleckstrin homology domain-containing family F member 2; May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport (By similarity). Enhances cellular sensitivity to TNF-induced apoptosis."},{"id":"ENSMUSP00000023689","abundance":0.268,"rank":15221,"name":"Ifnar1","annotation":"Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2 (By similarity). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway. Contributes to modulate the innate immune res [...] "},{"id":"ENSMUSP00000130728","abundance":0.268,"rank":15222,"name":"Grm6","annotation":"Metabotropic glutamate receptor 6; G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision."},{"id":"ENSMUSP00000108375","abundance":0.268,"rank":15223,"name":"Gm8334","annotation":"Predicted gene 8334."},{"id":"ENSMUSP00000154985","abundance":0.268,"rank":15224,"name":"Fam118a","annotation":"Protein FAM118A; Belongs to the FAM118 family."},{"id":"ENSMUSP00000132470","abundance":0.267,"rank":15225,"name":"Skint5","annotation":"Selection and upkeep of intraepithelial T-cells protein 5; May act by engaging a cell surface molecule on immature T- cells in the embryonic thymus."},{"id":"ENSMUSP00000108019","abundance":0.267,"rank":15226,"name":"Adgrg2","annotation":"Adhesion G-protein coupled receptor G2; Orphan receptor. Could be involved in a signal transduction pathway controlling epididymal function and male fertility. May regulate fluid exchange within epididymis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily."},{"id":"ENSMUSP00000069042","abundance":0.267,"rank":15227,"name":"Gbp10","annotation":"Guanylate-binding protein 10."},{"id":"ENSMUSP00000043143","abundance":0.267,"rank":15228,"name":"BC055324","annotation":"Uncharacterized protein C1orf112 homolog."},{"id":"ENSMUSP00000104613","abundance":0.267,"rank":15229,"name":"Zfp973","annotation":"Novel KRAB box and zinc finger, C2H2 type domain containing protein."},{"id":"ENSMUSP00000104630","abundance":0.267,"rank":15230,"name":"Zfp965","annotation":"Zinc finger protein 965."},{"id":"ENSMUSP00000047445","abundance":0.267,"rank":15231,"name":"Atad2b","annotation":"ATPase family, AAA domain-containing 2B."},{"id":"ENSMUSP00000136323","abundance":0.267,"rank":15232,"name":"Sgo2b","annotation":"Shugoshin 2B."},{"id":"ENSMUSP00000036551","abundance":0.267,"rank":15233,"name":"Vmn2r65","annotation":"Vomeronasal 2, receptor 65."},{"id":"ENSMUSP00000142010","abundance":0.267,"rank":15234,"name":"Pcdhgb5","annotation":"Protocadherin gamma subfamily B, 5."},{"id":"ENSMUSP00000136127","abundance":0.267,"rank":15235,"name":"Gm3727","annotation":"Predicted gene 3727."},{"id":"ENSMUSP00000041523","abundance":0.266,"rank":15236,"name":"AW209491","annotation":"UPF0415 protein C7orf25 homolog; Belongs to the UPF0415 family."},{"id":"ENSMUSP00000110578","abundance":0.266,"rank":15237,"name":"Fsip2l","annotation":"Fibrous sheath-interacting protein 2-like."},{"id":"ENSMUSP00000131905","abundance":0.266,"rank":15238,"name":"5830411N06Rik","annotation":"RIKEN cDNA 5830411N06 gene."},{"id":"ENSMUSP00000038820","abundance":0.266,"rank":15239,"name":"Spidr","annotation":"DNA repair-scaffolding protein; Plays a role in DNA double-strand break (DBS) repair via homologous recombination (HR). Serves as a scaffolding protein that helps to promote the recruitment of DNA-processing enzymes like the helicase BLM and recombinase RAD51 to site of DNA damage, and hence contributes to maintain genomic integrity (By similarity)."},{"id":"ENSMUSP00000058901","abundance":0.266,"rank":15240,"name":"Cdca4","annotation":"Cell division cycle-associated protein 4; May participate in the regulation of cell proliferation through the E2F/RB pathway (By similarity). May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation."},{"id":"ENSMUSP00000148587","abundance":0.266,"rank":15241,"name":"Zfp930","annotation":"Zinc finger protein 930."},{"id":"ENSMUSP00000021060","abundance":0.266,"rank":15242,"name":"Polg2","annotation":"DNA polymerase subunit gamma-2, mitochondrial; Mitochondrial polymerase processivity subunit. Stimulates the polymerase and exonuclease activities, and increases the processivity of the enzyme. Binds to ss-DNA."},{"id":"ENSMUSP00000033556","abundance":0.266,"rank":15243,"name":"Pgr15l","annotation":"G protein-coupled receptor 15-like; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000030533","abundance":0.266,"rank":15244,"name":"Vwa5b1","annotation":"Von Willebrand factor A domain-containing protein 5B1."},{"id":"ENSMUSP00000097965","abundance":0.266,"rank":15245,"name":"4930407I10Rik","annotation":"RIKEN cDNA 4930407I10 gene."},{"id":"ENSMUSP00000152112","abundance":0.266,"rank":15246,"name":"Mdga2","annotation":"MAM domain-containing glycosylphosphatidylinositol anchor protein 2; May be involved in cell-cell interactions."},{"id":"ENSMUSP00000093741","abundance":0.266,"rank":15247,"name":"3425401B19Rik","annotation":"Cardiac-enriched FHL2-interacting protein; Plays an important role in cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway."},{"id":"ENSMUSP00000108774","abundance":0.265,"rank":15248,"name":"Mrap2","annotation":"Melanocortin-2 receptor accessory protein 2; Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand- sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidence is required in vivo."},{"id":"ENSMUSP00000120314","abundance":0.265,"rank":15249,"name":"Fsip2","annotation":"Fibrous sheath-interacting protein 2; Plays a role in spermatogenesis."},{"id":"ENSMUSP00000029551","abundance":0.265,"rank":15250,"name":"1700094D03Rik","annotation":"Uncharacterized protein C1orf189 homolog."},{"id":"ENSMUSP00000037725","abundance":0.265,"rank":15251,"name":"Map3k10","annotation":"Mitogen-activated protein kinase kinase kinase 10; Activates the JUN N-terminal pathway."},{"id":"ENSMUSP00000033956","abundance":0.265,"rank":15252,"name":"Ido1","annotation":"Indoleamine 2,3-dioxygenase 1; Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of int [...] "},{"id":"ENSMUSP00000021645","abundance":0.265,"rank":15253,"name":"Dcaf4","annotation":"DDB1 and CUL4-associated factor 4."},{"id":"ENSMUSP00000022189","abundance":0.265,"rank":15254,"name":"Aggf1","annotation":"Angiogenic factor with G patch and FHA domains 1; Promotes angiogenesis and the proliferation of endothelial cells. Able to bind to endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion (By similarity)."},{"id":"ENSMUSP00000053766","abundance":0.265,"rank":15255,"name":"Exoc3l","annotation":"Exocyst complex component 3-like protein; As part of the exocyst, may play a role in regulated exocytosis of insulin granules; Belongs to the SEC6 family."},{"id":"ENSMUSP00000151463","abundance":0.264,"rank":15256,"name":"Esr2","annotation":"Estrogen receptor beta; Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 (ER-alpha), and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. May play a role in ovarian follicular growth and maturation; Belongs to the nuclear hormone receptor family. NR3 subfamily."},{"id":"ENSMUSP00000023612","abundance":0.264,"rank":15257,"name":"Ets2","annotation":"Protein C-ets-2; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity)."},{"id":"ENSMUSP00000043085","abundance":0.264,"rank":15258,"name":"Syde1","annotation":"Rho GTPase-activating protein SYDE1; GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1."},{"id":"ENSMUSP00000104923","abundance":0.264,"rank":15259,"name":"Slc35c2","annotation":"Solute carrier family 35 member C2; May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells (By similarity)."},{"id":"ENSMUSP00000033463","abundance":0.264,"rank":15260,"name":"Slc9a9","annotation":"Sodium/hydrogen exchanger 9; May act in electroneutral exchange of protons for Na(+) across membranes. Involved in the effusion of Golgi luminal H(+) in exchange for cytosolic cations. Involved in organelle ion homeostasis by contributing to the maintenance of the unique acidic pH values of the Golgi and post-Golgi compartments in the cell (By similarity). Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family."},{"id":"ENSMUSP00000137628","abundance":0.264,"rank":15261,"name":"Nlrc3","annotation":"Protein NLRC3; Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination. Inhibits the PI3K-AKT-mTOR [...] "},{"id":"ENSMUSP00000025585","abundance":0.264,"rank":15262,"name":"Cblif","annotation":"Cobalamin binding intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity). Belongs to the eukaryotic cobalamin transport proteins family."},{"id":"ENSMUSP00000148211","abundance":0.264,"rank":15263,"name":"Nek5","annotation":"Serine/threonine-protein kinase Nek5; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily."},{"id":"ENSMUSP00000106228","abundance":0.264,"rank":15264,"name":"4930449I24Rik","annotation":"RIKEN cDNA 4930449I24 gene."},{"id":"ENSMUSP00000141587","abundance":0.263,"rank":15265,"name":"Pcdha6","annotation":"Protocadherin alpha 6."},{"id":"ENSMUSP00000020846","abundance":0.263,"rank":15266,"name":"Srebf1","annotation":"Processed sterol regulatory element-binding protein 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1- containing promoters."},{"id":"ENSMUSP00000033009","abundance":0.263,"rank":15267,"name":"Thap12","annotation":"52 kDa repressor of the inhibitor of the protein kinase; Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth."},{"id":"ENSMUSP00000108931","abundance":0.263,"rank":15268,"name":"B3gnt7","annotation":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7; May be involved in keratane sulfate biosynthesis. Transfers N-acetylgalactosamine on to keratan sulfate-related glycans. May play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues (By similarity); Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000057159","abundance":0.263,"rank":15269,"name":"Zfp418","annotation":"Zinc finger protein 418."},{"id":"ENSMUSP00000054426","abundance":0.263,"rank":15270,"name":"F2rl3","annotation":"Proteinase-activated receptor 4; Receptor for activated thrombin or trypsin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000139132","abundance":0.263,"rank":15271,"name":"Slfn14","annotation":"C-terminally truncated SLFN14 endoribonuclease; [Protein SLFN14]: Shows no ribosome-associated and endoribonuclease activities."},{"id":"ENSMUSP00000137928","abundance":0.262,"rank":15272,"name":"Zfp748","annotation":"Zinc finger protein 748."},{"id":"ENSMUSP00000107047","abundance":0.262,"rank":15273,"name":"Ildr2","annotation":"Immunoglobulin-like domain-containing receptor 2; May be involved in lipid homeostasis and ER stress pathways."},{"id":"ENSMUSP00000139506","abundance":0.262,"rank":15274,"name":"Gm28079","annotation":"Predicted gene, 33815."},{"id":"ENSMUSP00000141626","abundance":0.262,"rank":15275,"name":"Gm33815","annotation":"Predicted gene, 33815."},{"id":"ENSMUSP00000043055","abundance":0.262,"rank":15276,"name":"Adgrg6","annotation":"Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons these functions are mediated via G-protein- signaling pathways. Regulates also neural, cardiac and ear development via G-protein- and/or N-terminus- dependent signaling. May act as a receptor for PRNP which may promote myelin homeostasis. ECO:0000250|UniProtKB:Q86SQ4."},{"id":"ENSMUSP00000126301","abundance":0.262,"rank":15277,"name":"Ascc1","annotation":"Activating signal cointegrator 1 complex subunit 1; Plays a role in DNA damage repair as component of the ASCC complex. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. In cells responding to gastrin-activated paracrine signals, it is involved in the induction of SERPINB2 expression by gastrin. May also play a role in the development of neuromuscular junction."},{"id":"ENSMUSP00000070239","abundance":0.262,"rank":15278,"name":"Tg","annotation":"Thyroglobulin; Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (By similarity). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling (By similarity). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable)."},{"id":"ENSMUSP00000008573","abundance":0.262,"rank":15279,"name":"Herpud2","annotation":"Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein; Could be involved in the unfolded protein response (UPR) pathway."},{"id":"ENSMUSP00000097847","abundance":0.262,"rank":15280,"name":"Zfp788","annotation":"Zinc finger protein 788."},{"id":"ENSMUSP00000029369","abundance":0.261,"rank":15281,"name":"Sohlh2","annotation":"Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2; Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I."},{"id":"ENSMUSP00000053235","abundance":0.261,"rank":15282,"name":"Neurl4","annotation":"Neuralized-like protein 4; Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers (By similarity)."},{"id":"ENSMUSP00000139045","abundance":0.261,"rank":15283,"name":"Nav2","annotation":"Neuron navigator 2."},{"id":"ENSMUSP00000025993","abundance":0.261,"rank":15284,"name":"Slit1","annotation":"Slit homolog 1 protein; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb."},{"id":"ENSMUSP00000086589","abundance":0.261,"rank":15285,"name":"Zdhhc14","annotation":"Probable palmitoyltransferase ZDHHC14; Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily."},{"id":"ENSMUSP00000113670","abundance":0.26,"rank":15286,"name":"Gm4631","annotation":"Predicted gene 4631."},{"id":"ENSMUSP00000104673","abundance":0.26,"rank":15287,"name":"Gm4724","annotation":"Predicted gene 4724."},{"id":"ENSMUSP00000112478","abundance":0.26,"rank":15288,"name":"Gm14434","annotation":"Predicted gene 14434."},{"id":"ENSMUSP00000104636","abundance":0.26,"rank":15289,"name":"Gm2026","annotation":"Predicted gene 2026."},{"id":"ENSMUSP00000137539","abundance":0.26,"rank":15290,"name":"Gm2007","annotation":"Predicted gene 2007."},{"id":"ENSMUSP00000136499","abundance":0.26,"rank":15291,"name":"Gm11007","annotation":"Predicted gene 11007."},{"id":"ENSMUSP00000104618","abundance":0.26,"rank":15292,"name":"Gm14308","annotation":"Predicted gene 14308."},{"id":"ENSMUSP00000046503","abundance":0.26,"rank":15293,"name":"Nlrp4c","annotation":"NACHT, LRR and PYD domains-containing protein 4C; May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors."},{"id":"ENSMUSP00000106345","abundance":0.26,"rank":15294,"name":"Ankrd61","annotation":"Ankyrin repeat domain-containing protein 61."},{"id":"ENSMUSP00000032469","abundance":0.26,"rank":15295,"name":"Mbd4","annotation":"Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein."},{"id":"ENSMUSP00000027876","abundance":0.26,"rank":15296,"name":"Scyl3","annotation":"Protein-associating with the carboxyl-terminal domain of ezrin; May play a role in regulating cell adhesion/migration complexes in migrating cells."},{"id":"ENSMUSP00000028804","abundance":0.26,"rank":15297,"name":"Cdc25b","annotation":"M-phase inducer phosphatase 2; Tyrosine protein phosphatase which functions as a dosage- dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2- dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity (By similarity)."},{"id":"ENSMUSP00000054451","abundance":0.26,"rank":15298,"name":"Clec14a","annotation":"C-type lectin domain family 14 member A."},{"id":"ENSMUSP00000016023","abundance":0.26,"rank":15299,"name":"Fam184b","annotation":"Protein FAM184B."},{"id":"ENSMUSP00000018382","abundance":0.26,"rank":15300,"name":"Gdf9","annotation":"Growth/differentiation factor 9; Required for ovarian folliculogenesis; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000129513","abundance":0.259,"rank":15301,"name":"Card10","annotation":"Caspase recruitment domain-containing protein 10; Activates NF-kappa-B via BCL10 and IKK."},{"id":"ENSMUSP00000064393","abundance":0.259,"rank":15302,"name":"Dach2","annotation":"Dachshund homolog 2; Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlyin [...] "},{"id":"ENSMUSP00000010085","abundance":0.259,"rank":15303,"name":"Nxf2","annotation":"Nuclear RNA export factor 2."},{"id":"ENSMUSP00000149432","abundance":0.259,"rank":15304,"name":"Olfr1378","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000025751","abundance":0.259,"rank":15305,"name":"Ighmbp2","annotation":"DNA-binding protein SMUBP-2; 5' to 3' helicase that unwinds RNA and DNA duplices in an ATP-dependent reaction. Acts as a transcription regulator. Required for the transcriptional activation of the flounder liver-type antifreeze protein gene. Exhibits strong binding specificity to the enhancer element B of the flounder antifreeze protein gene intron. Binds to the insulin II gene RIPE3B enhancer region (By similarity). May be involved in translation. DNA-binding protein specific to 5'-phosphorylated single-stranded guanine-rich sequence related to the immunoglobulin mu chain switch regio [...] "},{"id":"ENSMUSP00000055374","abundance":0.259,"rank":15306,"name":"Zfp768","annotation":"Zinc finger protein 768; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000032877","abundance":0.259,"rank":15307,"name":"Ddias","annotation":"DNA damage-induced apoptosis suppressor protein; May be an anti-apoptotic protein involved in DNA repair or cell survival."},{"id":"ENSMUSP00000021324","abundance":0.258,"rank":15308,"name":"Map3k14","annotation":"Mitogen-activated protein kinase kinase kinase 14; Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non- canonical pathway. Could act in a receptor-selective manner. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily."},{"id":"ENSMUSP00000061529","abundance":0.258,"rank":15309,"name":"Cdcp3","annotation":"Putative DMBT1-like protein."},{"id":"ENSMUSP00000092054","abundance":0.258,"rank":15310,"name":"Fv1","annotation":"Friend virus susceptibility protein 1; Retroviral restriction factor that prevents infection by gammaretroviruses. Acts by interacting with the capsid protein ca after entry of the virus into the cell. This interaction presumably disrupt the capsid thereby inactivating the viral genome, making it unable to enter host nucleus and integrate into host genome."},{"id":"ENSMUSP00000028600","abundance":0.258,"rank":15311,"name":"Hipk3","annotation":"Homeodomain-interacting protein kinase 3; Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphoryla [...] "},{"id":"ENSMUSP00000018625","abundance":0.258,"rank":15312,"name":"Appbp2","annotation":"Amyloid protein-binding protein 2; May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface (By similarity)."},{"id":"ENSMUSP00000135720","abundance":0.258,"rank":15313,"name":"Zfp989","annotation":"Zinc finger protein 989."},{"id":"ENSMUSP00000042582","abundance":0.258,"rank":15314,"name":"AW551984","annotation":"Expressed sequence AW551984."},{"id":"ENSMUSP00000134576","abundance":0.258,"rank":15315,"name":"Cfap221","annotation":"Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. Belongs to the PCDP1 family."},{"id":"ENSMUSP00000157307","abundance":0.257,"rank":15316,"name":"Vmn2r-ps159","annotation":"Vomeronasal 2, receptor, pseudogene 159."},{"id":"ENSMUSP00000041819","abundance":0.257,"rank":15317,"name":"Map3k9","annotation":"Mitogen-activated protein kinase kinase kinase 9; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial [...] "},{"id":"ENSMUSP00000134263","abundance":0.257,"rank":15318,"name":"Slit2","annotation":"Slit homolog 2 protein C-product; Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal chord development, may play a role in guiding commissural axon [...] "},{"id":"ENSMUSP00000118385","abundance":0.257,"rank":15319,"name":"Lipo1","annotation":"Lipase; Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000130491","abundance":0.257,"rank":15320,"name":"Cntln","annotation":"Centlein; Required for centrosome cohesion and recruitment of CEP68 to centrosomes."},{"id":"ENSMUSP00000052869","abundance":0.257,"rank":15321,"name":"Mblac1","annotation":"Metallo-beta-lactamase domain-containing protein 1."},{"id":"ENSMUSP00000062411","abundance":0.257,"rank":15322,"name":"Ccdc149","annotation":"Coiled-coil domain-containing 149."},{"id":"ENSMUSP00000021416","abundance":0.256,"rank":15323,"name":"Mbip","annotation":"MAP3K12-binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4."},{"id":"ENSMUSP00000133967","abundance":0.256,"rank":15324,"name":"L3mbtl2","annotation":"Lethal(3)malignant brain tumor-like protein 2; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity)."},{"id":"ENSMUSP00000078160","abundance":0.256,"rank":15325,"name":"Letm2","annotation":"LETM1 domain-containing protein LETM2, mitochondrial."},{"id":"ENSMUSP00000001081","abundance":0.256,"rank":15326,"name":"Rmnd5b","annotation":"E3 ubiquitin-protein transferase RMND5B; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1."},{"id":"ENSMUSP00000031276","abundance":0.256,"rank":15327,"name":"Rasgef1b","annotation":"Ras-GEF domain-containing family member 1B; Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro)."},{"id":"ENSMUSP00000056646","abundance":0.256,"rank":15328,"name":"Gpank1","annotation":"G patch domain and ankyrin repeat-containing protein 1."},{"id":"ENSMUSP00000034739","abundance":0.256,"rank":15329,"name":"Rnf111","annotation":"E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development. Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and subsequent degrad [...] "},{"id":"ENSMUSP00000153476","abundance":0.255,"rank":15330,"name":"Gm49345","annotation":"Predicted gene, 49345."},{"id":"ENSMUSP00000098286","abundance":0.255,"rank":15331,"name":"Gdf2","annotation":"Growth/differentiation factor 2; Potent circulating inhibitor of angiogenesis (By similarity). Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG."},{"id":"ENSMUSP00000000275","abundance":0.255,"rank":15332,"name":"Glra3","annotation":"Glycine receptor subunit alpha-3; Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Contributes to increased pain perception in response to increased prostaglandin E2 levels. Plays a role in the regulation of breathing rhythm, especially of the duration of the [...] "},{"id":"ENSMUSP00000098285","abundance":0.255,"rank":15333,"name":"Gm5460","annotation":"Predicted gene 5460."},{"id":"ENSMUSP00000038375","abundance":0.255,"rank":15334,"name":"Parpbp","annotation":"PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity)."},{"id":"ENSMUSP00000106241","abundance":0.254,"rank":15335,"name":"Gm6370","annotation":"Predicted gene 6370."},{"id":"ENSMUSP00000113792","abundance":0.254,"rank":15336,"name":"Aasdh","annotation":"Beta-alanine-activating enzyme; Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an as yet unknown acceptor via an amide bond. May be required for a post-translational protein modification or for post-transcriptional modification of an RNA."},{"id":"ENSMUSP00000127441","abundance":0.254,"rank":15337,"name":"Smim7","annotation":"Small integral membrane protein 7."},{"id":"ENSMUSP00000135898","abundance":0.254,"rank":15338,"name":"Gm4070","annotation":"Interferon-induced very large GTPase 1."},{"id":"ENSMUSP00000138950","abundance":0.254,"rank":15339,"name":"Gvin1","annotation":"Interferon-induced very large GTPase 1."},{"id":"ENSMUSP00000041848","abundance":0.254,"rank":15340,"name":"Trub2","annotation":"Mitochondrial mRNA pseudouridine synthase Trub2; Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt- mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation."},{"id":"ENSMUSP00000142248","abundance":0.254,"rank":15341,"name":"Il1rl2","annotation":"Interleukin-1 receptor-like 2; Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36- dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway."},{"id":"ENSMUSP00000148433","abundance":0.254,"rank":15342,"name":"Gm11639","annotation":"Predicted gene 11639."},{"id":"ENSMUSP00000069275","abundance":0.254,"rank":15343,"name":"Zfp618","annotation":"Zinc finger protein 618; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000131443","abundance":0.254,"rank":15344,"name":"Parvg","annotation":"Gamma-parvin; Probably plays a role in the regulation of cell adhesion and cytoskeleton organization; Belongs to the parvin family."},{"id":"ENSMUSP00000048558","abundance":0.254,"rank":15345,"name":"Cpa4","annotation":"Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family."},{"id":"ENSMUSP00000128674","abundance":0.254,"rank":15346,"name":"Naalad2","annotation":"N-acetylated-alpha-linked acidic dipeptidase 2; Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivates the peptide neurotransmitter N-acetylaspartylglutamate."},{"id":"ENSMUSP00000021888","abundance":0.254,"rank":15347,"name":"Ctsq","annotation":"Cathepsin Q; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000134066","abundance":0.254,"rank":15348,"name":"Spag17","annotation":"Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts."},{"id":"ENSMUSP00000061355","abundance":0.253,"rank":15349,"name":"1810024B03Rik","annotation":"RIKEN cDNA 1810024B03 gene."},{"id":"ENSMUSP00000053955","abundance":0.253,"rank":15350,"name":"Usp42","annotation":"Ubiquitin carboxyl-terminal hydrolase 42; Deubiquitinating enzyme which may play an important role during spermatogenesis; Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000109425","abundance":0.253,"rank":15351,"name":"Igsf5","annotation":"Immunoglobulin superfamily member 5; Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells; Belongs to the immunoglobulin superfamily."},{"id":"ENSMUSP00000026078","abundance":0.253,"rank":15352,"name":"BC051665","annotation":"cDNA sequence BC051665; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000122709","abundance":0.253,"rank":15353,"name":"Tmprss11g","annotation":"Transmembrane protease serine 11G non-catalytic chain."},{"id":"ENSMUSP00000040416","abundance":0.253,"rank":15354,"name":"Dlgap5","annotation":"Disks large-associated protein 5; Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells (By similarity)."},{"id":"ENSMUSP00000031879","abundance":0.253,"rank":15355,"name":"Tcaf2","annotation":"TRPM8 channel-associated factor 2; Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8- dependent manner."},{"id":"ENSMUSP00000008999","abundance":0.253,"rank":15356,"name":"Hdac5","annotation":"Histone deacetylase 5; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By s [...] "},{"id":"ENSMUSP00000114931","abundance":0.253,"rank":15357,"name":"Fsd1l","annotation":"FSD1-like protein."},{"id":"ENSMUSP00000116281","abundance":0.253,"rank":15358,"name":"Zfp986","annotation":"Zinc finger protein 986."},{"id":"ENSMUSP00000147654","abundance":0.253,"rank":15359,"name":"Cyld","annotation":"Ubiquitin carboxyl-terminal hydrolase CYLD; Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-alpha-induced necroptosis. Plays an important role in the regulation of pathways leading to NF-kappa-B activation. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regul [...] "},{"id":"ENSMUSP00000070463","abundance":0.253,"rank":15360,"name":"Zfp37","annotation":"Zinc finger protein 37; May have a role in regulating spermiogenesis."},{"id":"ENSMUSP00000109591","abundance":0.253,"rank":15361,"name":"4932429P05Rik","annotation":"RIKEN cDNA 4932429P05 gene."},{"id":"ENSMUSP00000050970","abundance":0.252,"rank":15362,"name":"Zswim3","annotation":"Zinc finger SWIM domain-containing protein 3."},{"id":"ENSMUSP00000039806","abundance":0.252,"rank":15363,"name":"Gm11992","annotation":"Uncharacterized protein C7orf57 homolog."},{"id":"ENSMUSP00000048877","abundance":0.252,"rank":15364,"name":"Parp2","annotation":"Poly [ADP-ribose] polymerase 2; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP- ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP-ribosyl groups are transferred to the 2'- position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units (By similarity). ADP- ribosylation follows DNA damage and appears as an obligatory ste [...] "},{"id":"ENSMUSP00000087511","abundance":0.252,"rank":15365,"name":"Sybu","annotation":"Syntabulin; Part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development."},{"id":"ENSMUSP00000136757","abundance":0.252,"rank":15366,"name":"Gm7694","annotation":"Predicted gene 7694."},{"id":"ENSMUSP00000044135","abundance":0.252,"rank":15367,"name":"Mfhas1","annotation":"Malignant fibrous histiocytoma-amplified sequence 1 homolog; Probable GTP-binding protein (By similarity). Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways. Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor (By similarity). Both inh [...] "},{"id":"ENSMUSP00000026911","abundance":0.252,"rank":15368,"name":"Ccr1","annotation":"C-C chemokine receptor type 1; Receptor for a C-C type chemokine. Binds to MIP-1-alpha, RANTES, and less efficiently, to MIP-1-beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation."},{"id":"ENSMUSP00000047508","abundance":0.252,"rank":15369,"name":"Pcsk7","annotation":"Proprotein convertase subtilisin/kexin type 7; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway; Belongs to the peptidase S8 family."},{"id":"ENSMUSP00000052285","abundance":0.252,"rank":15370,"name":"Catsperg2","annotation":"Cation channel sperm-associated protein subunit gamma 2; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization."},{"id":"ENSMUSP00000034618","abundance":0.252,"rank":15371,"name":"Pdzd3","annotation":"Na(+)/H(+) exchange regulatory cofactor NHE-RF4; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (By similarity). Stimulates SLC9A3 activity in the presence of elevated calcium ions (By similarity)."},{"id":"ENSMUSP00000047597","abundance":0.251,"rank":15372,"name":"Rorb","annotation":"Nuclear receptor ROR-beta; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated p [...] "},{"id":"ENSMUSP00000024983","abundance":0.251,"rank":15373,"name":"Ift140","annotation":"Intraflagellar transport protein 140 homolog; Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein- coupled receptors (GPCRs) (By similarity). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells."},{"id":"ENSMUSP00000032705","abundance":0.251,"rank":15374,"name":"Rhpn2","annotation":"Rhophilin-2; Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity (By similarity)."},{"id":"ENSMUSP00000071872","abundance":0.251,"rank":15375,"name":"Bmper","annotation":"BMP-binding endothelial regulator protein; Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes."},{"id":"ENSMUSP00000047270","abundance":0.25,"rank":15376,"name":"Chrnb1","annotation":"Acetylcholine receptor subunit beta; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane."},{"id":"ENSMUSP00000042698","abundance":0.25,"rank":15377,"name":"Cyth4","annotation":"Cytohesin-4; Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP (By similarity)."},{"id":"ENSMUSP00000038671","abundance":0.25,"rank":15378,"name":"Manea","annotation":"Glycoprotein endo-alpha-1,2-mannosidase."},{"id":"ENSMUSP00000158578","abundance":0.25,"rank":15379,"name":"Ppp1r32","annotation":"Protein phosphatase 1 regulatory subunit 32."},{"id":"ENSMUSP00000055427","abundance":0.25,"rank":15380,"name":"Cdc25c","annotation":"M-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). May be involved in regulating the proliferation of T-lymphocytes following cytokine stimulation."},{"id":"ENSMUSP00000096257","abundance":0.25,"rank":15381,"name":"Thsd4","annotation":"Thrombospondin type-1 domain-containing protein 4; Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN."},{"id":"ENSMUSP00000022831","abundance":0.25,"rank":15382,"name":"Khnyn","annotation":"Protein KHNYN; Belongs to the N4BP1 family."},{"id":"ENSMUSP00000048205","abundance":0.249,"rank":15383,"name":"Cnst","annotation":"Consortin; Required for targeting of connexins to the plasma membrane."},{"id":"ENSMUSP00000002275","abundance":0.249,"rank":15384,"name":"Vrk3","annotation":"Inactive serine/threonine-protein kinase VRK3; Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus."},{"id":"ENSMUSP00000104609","abundance":0.249,"rank":15385,"name":"Gm14305","annotation":"Novel KRAB box and zinc finger, C2H2 type domain containing protein."},{"id":"ENSMUSP00000032560","abundance":0.249,"rank":15386,"name":"Ppm1n","annotation":"Probable protein phosphatase 1N."},{"id":"ENSMUSP00000113095","abundance":0.249,"rank":15387,"name":"Nlrp4b","annotation":"NACHT, LRR and PYD domains-containing protein 4B; May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors."},{"id":"ENSMUSP00000103712","abundance":0.249,"rank":15388,"name":"Abhd18","annotation":"Protein ABHD18; Belongs to the AB hydrolase superfamily."},{"id":"ENSMUSP00000109340","abundance":0.249,"rank":15389,"name":"Wdr34","annotation":"WD repeat-containing protein 34; Critical for ciliary functions, essential to normal development and survival, most probably as a previously unrecognized component of the mammalian dynein-motor-based intraflagellar transport (IFT) machinery. Acts as a negative regulator of the Toll-like and IL- 1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation (By similarity)."},{"id":"ENSMUSP00000082127","abundance":0.249,"rank":15390,"name":"Serpina3b","annotation":"Serine protease inhibitor A3B."},{"id":"ENSMUSP00000052584","abundance":0.248,"rank":15391,"name":"Lrrk2","annotation":"Leucine-rich repeat serine/threonine-protein kinase 2; Serine/threonine-protein kinase which phosphorylates a broad range of proteins involved in multiple processes such as neuronal plasticity, autophagy, and vesicle trafficking. Is a key regulator of RAB GTPases by regulating the GTP/GDP exchange and interaction partners of RABs through phosphorylation. Phosphorylates RAB3A, RAB3B, RAB3C, RAB3D, RAB8A, RAB8B, RAB10, RAB12, RAB35, and RAB43. Regulates the RAB3IP-catalyzed GDP/GTP exchange for RAB8A through the phosphorylation of 'Thr-72' on RAB8A (By similarity). Inhibits the interacti [...] "},{"id":"ENSMUSP00000030508","abundance":0.248,"rank":15392,"name":"Pax7","annotation":"Paired box protein Pax-7; Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation. Belongs to the paired homeobox family."},{"id":"ENSMUSP00000038972","abundance":0.248,"rank":15393,"name":"Sdk2","annotation":"Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types: the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions."},{"id":"ENSMUSP00000129680","abundance":0.248,"rank":15394,"name":"Igfn1","annotation":"Immunoglobulin-like and fibronectin type III domain-containing protein 1."},{"id":"ENSMUSP00000091955","abundance":0.248,"rank":15395,"name":"Iqcd","annotation":"Dynein regulatory complex protein 10; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the DRC10 family."},{"id":"ENSMUSP00000128106","abundance":0.248,"rank":15396,"name":"Vmn2r116","annotation":"Vomeronasal type-2 receptor 116; Receptor for the Esp1 pheromone. Mediates the response to Esp1 which enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Belongs to the G-protein coupled receptor 3 family."},{"id":"ENSMUSP00000070610","abundance":0.248,"rank":15397,"name":"Sh3tc1","annotation":"SH3 domain and tetratricopeptide repeats 1."},{"id":"ENSMUSP00000044731","abundance":0.248,"rank":15398,"name":"Fam102a","annotation":"Protein FAM102A; May play a role in estrogen action."},{"id":"ENSMUSP00000057495","abundance":0.247,"rank":15399,"name":"Zfp786","annotation":"Zinc finger protein 786; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000016124","abundance":0.247,"rank":15400,"name":"Lrrc27","annotation":"Leucine-rich repeat-containing protein 27."},{"id":"ENSMUSP00000086657","abundance":0.247,"rank":15401,"name":"Tex13c3","annotation":"TEX13 family member C3."},{"id":"ENSMUSP00000105082","abundance":0.247,"rank":15402,"name":"Lpin3","annotation":"Phosphatidate phosphatase LPIN3; Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis; Belongs to the lipin family."},{"id":"ENSMUSP00000105067","abundance":0.247,"rank":15403,"name":"Ptprt","annotation":"Receptor-type tyrosine-protein phosphatase T; May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily."},{"id":"ENSMUSP00000132914","abundance":0.247,"rank":15404,"name":"Armcx4","annotation":"Armadillo repeat-containing, X-linked 4."},{"id":"ENSMUSP00000086748","abundance":0.246,"rank":15405,"name":"Fgd5","annotation":"FYVE, RhoGEF and PH domain-containing protein 5; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF- induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape (By similarity)."},{"id":"ENSMUSP00000038678","abundance":0.246,"rank":15406,"name":"Fndc3c1","annotation":"Fibronectin type III domain containing protein 3C1."},{"id":"ENSMUSP00000140272","abundance":0.246,"rank":15407,"name":"Gsdmc3","annotation":"Gasdermin-C3; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family."},{"id":"ENSMUSP00000101951","abundance":0.246,"rank":15408,"name":"Tnrc6c","annotation":"Trinucleotide repeat-containing gene 6C protein; Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes (By similarity)."},{"id":"ENSMUSP00000072019","abundance":0.245,"rank":15409,"name":"Ccdc189","annotation":"Coiled-coil domain-containing protein 189."},{"id":"ENSMUSP00000020157","abundance":0.245,"rank":15410,"name":"Apaf1","annotation":"Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity)."},{"id":"ENSMUSP00000148653","abundance":0.245,"rank":15411,"name":"Alkbh8","annotation":"Alkylated DNA repair protein alkB homolog 8; Catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys) (By similarity). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5- methylcarboxymethyl uridine at the wobble position of the a [...] "},{"id":"ENSMUSP00000103923","abundance":0.245,"rank":15412,"name":"Lrfn1","annotation":"Leucine-rich repeat and fibronectin type III domain-containing protein 1; Promotes neurite outgrowth in hippocampal neurons. Involved in the regulation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1; Belongs to the LRFN family."},{"id":"ENSMUSP00000094892","abundance":0.245,"rank":15413,"name":"L3mbtl4","annotation":"Lethal(3)malignant brain tumor-like protein 4; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity)."},{"id":"ENSMUSP00000149966","abundance":0.245,"rank":15414,"name":"Olfr1342","annotation":"Olfactory receptor MOR258-3."},{"id":"ENSMUSP00000061341","abundance":0.245,"rank":15415,"name":"Mei4","annotation":"Meiosis-specific protein MEI4; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis ; Belongs to the MEI4L family."},{"id":"ENSMUSP00000040919","abundance":0.245,"rank":15416,"name":"Hs3st6","annotation":"Heparan sulfate glucosamine 3-O-sulfotransferase 6; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate."},{"id":"ENSMUSP00000047623","abundance":0.245,"rank":15417,"name":"Wtip","annotation":"Wilms tumor protein 1-interacting protein; Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadheri [...] "},{"id":"ENSMUSP00000095571","abundance":0.245,"rank":15418,"name":"Sigirr","annotation":"Single Ig IL-1-related receptor; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor- proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity)."},{"id":"ENSMUSP00000029141","abundance":0.245,"rank":15419,"name":"Mmp24","annotation":"Processed matrix metalloproteinase-24; Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell- cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to  [...] "},{"id":"ENSMUSP00000105954","abundance":0.244,"rank":15420,"name":"Tmem87b","annotation":"Transmembrane protein 87B; May be involved in retrograde transport from endosomes to the trans-Golgi network (TGN)."},{"id":"ENSMUSP00000088320","abundance":0.244,"rank":15421,"name":"Scrn3","annotation":"Secernin-3; Belongs to the peptidase C69 family. Secernin subfamily."},{"id":"ENSMUSP00000130879","abundance":0.244,"rank":15422,"name":"Islr2","annotation":"Immunoglobulin superfamily containing leucine-rich repeat protein 2; Required for axon extension during neural development."},{"id":"ENSMUSP00000106188","abundance":0.244,"rank":15423,"name":"Lyst","annotation":"Lysosomal-trafficking regulator; May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules."},{"id":"ENSMUSP00000043040","abundance":0.244,"rank":15424,"name":"Ccdc138","annotation":"Coiled-coil domain-containing protein 138."},{"id":"ENSMUSP00000003621","abundance":0.244,"rank":15425,"name":"Ess2","annotation":"Splicing factor ESS-2 homolog; May be involved in pre-mRNA splicing."},{"id":"ENSMUSP00000052585","abundance":0.243,"rank":15426,"name":"Tprg","annotation":"Tumor protein p63-regulated gene 1 protein."},{"id":"ENSMUSP00000001040","abundance":0.243,"rank":15427,"name":"Icam4","annotation":"Intercellular adhesion molecule 4; Adhesion molecule that binds to leukocyte adhesion LFA-1 protein LFA-1 (integrin alpha-L/beta-2). ICAM4 is also a ligand for alpha-4/beta-1 and alpha-V integrins (By similarity). Isoform 2 may modulate binding of membrane-associated ICAM4; Belongs to the immunoglobulin superfamily. ICAM family."},{"id":"ENSMUSP00000099434","abundance":0.243,"rank":15428,"name":"E2f1","annotation":"Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] "},{"id":"ENSMUSP00000047720","abundance":0.243,"rank":15429,"name":"Mettl17","annotation":"Methyltransferase-like protein 17, mitochondrial; May be a component of the mitochondrial small ribosomal subunit; Belongs to the methyltransferase superfamily. Rsm22 family."},{"id":"ENSMUSP00000126356","abundance":0.243,"rank":15430,"name":"Gm3526","annotation":"Predicted gene 3526."},{"id":"ENSMUSP00000034737","abundance":0.242,"rank":15431,"name":"Khdc3","annotation":"KH domain-containing protein 3; Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA- independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA."},{"id":"ENSMUSP00000062158","abundance":0.242,"rank":15432,"name":"Lrrc4","annotation":"Leucine-rich repeat-containing protein 4; Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays an important role for auditory synaptic responses. Involved in the suppression of glioma."},{"id":"ENSMUSP00000128372","abundance":0.242,"rank":15433,"name":"Gm6337","annotation":"Predicted gene 6337."},{"id":"ENSMUSP00000127156","abundance":0.242,"rank":15434,"name":"Gm3115","annotation":"Predicted gene 3115."},{"id":"ENSMUSP00000155404","abundance":0.242,"rank":15435,"name":"Troap","annotation":"Tastin; Could be involved with bystin and trophinin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation."},{"id":"ENSMUSP00000022023","abundance":0.242,"rank":15436,"name":"Trpc7","annotation":"Short transient receptor potential channel 7; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily."},{"id":"ENSMUSP00000030937","abundance":0.242,"rank":15437,"name":"Mmp23","annotation":"Matrix metalloproteinase-23, soluble form; Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity); Belongs to the peptidase M10A family."},{"id":"ENSMUSP00000128382","abundance":0.242,"rank":15438,"name":"Atp23","annotation":"Mitochondrial inner membrane protease ATP23 homolog."},{"id":"ENSMUSP00000092686","abundance":0.241,"rank":15439,"name":"Crispld1","annotation":"Cysteine-rich secretory protein LCCL domain-containing 1."},{"id":"ENSMUSP00000105212","abundance":0.241,"rank":15440,"name":"Mctp1","annotation":"Multiple C2 and transmembrane domain-containing protein 1; Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity."},{"id":"ENSMUSP00000075059","abundance":0.241,"rank":15441,"name":"Ttc41","annotation":"Tetratricopeptide repeat protein 41."},{"id":"ENSMUSP00000093460","abundance":0.241,"rank":15442,"name":"Moxd1","annotation":"DBH-like monooxygenase protein 1; Belongs to the copper type II ascorbate-dependent monooxygenase family."},{"id":"ENSMUSP00000038638","abundance":0.241,"rank":15443,"name":"Fbxl8","annotation":"F-box/LRR-repeat protein 8; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000048238","abundance":0.241,"rank":15444,"name":"Lmtk2","annotation":"Serine/threonine-protein kinase LMTK2; Phosphorylates PPP1C, phosphorylase b and CFTR. Belongs to the protein kinase superfamily. Tyr protein kinase family."},{"id":"ENSMUSP00000124327","abundance":0.241,"rank":15445,"name":"Cntn5","annotation":"Contactin-5; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons (By similarity). Involved in neuronal activity in the auditory system."},{"id":"ENSMUSP00000137400","abundance":0.241,"rank":15446,"name":"Oaz1","annotation":"Ornithine decarboxylase antizyme 1; Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin- independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (By similarity). Stabilizes AZIN2 by interfering with its ubiquitination. Also in [...] "},{"id":"ENSMUSP00000025403","abundance":0.241,"rank":15447,"name":"Impa2","annotation":"Inositol monophosphatase 2; Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain (By similarity)."},{"id":"ENSMUSP00000047284","abundance":0.241,"rank":15448,"name":"Tespa1","annotation":"Protein TESPA1; May play a role in the regulation of inositol 1,4,5- trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment (By similarity). Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes."},{"id":"ENSMUSP00000059834","abundance":0.241,"rank":15449,"name":"Oog3","annotation":"Oogenesin-3; Belongs to the PRAME family."},{"id":"ENSMUSP00000149016","abundance":0.24,"rank":15450,"name":"Olfr711","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000087727","abundance":0.24,"rank":15451,"name":"Gm4841","annotation":"Interferon-gamma-inducible GTPase Ifgga3 protein."},{"id":"ENSMUSP00000022650","abundance":0.24,"rank":15452,"name":"Pibf1","annotation":"Progesterone immunomodulatory-binding factor 1."},{"id":"ENSMUSP00000049490","abundance":0.24,"rank":15453,"name":"Nacad","annotation":"NAC-alpha domain-containing protein 1; May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity); Belongs to the NAC-alpha family."},{"id":"ENSMUSP00000046203","abundance":0.24,"rank":15454,"name":"Tex13b","annotation":"Testis expressed gene 13."},{"id":"ENSMUSP00000034991","abundance":0.24,"rank":15455,"name":"Tbx18","annotation":"T-box transcription factor TBX18; Acts as transcriptional repressor involved in developmental processes of a variety of tissues and organs, including the heart, the coronary vessels, the ureter, and the vertebral column. Required for embryonic development of the sino atrial node (SAN) head area."},{"id":"ENSMUSP00000103227","abundance":0.24,"rank":15456,"name":"Arhgap23","annotation":"Rho GTPase-activating protein 23; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state."},{"id":"ENSMUSP00000118458","abundance":0.24,"rank":15457,"name":"Pla2g4b","annotation":"Cytosolic phospholipase A2 beta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position with a preference for arachidonoyl phospholipids. Has a much weaker activity than PLA2G4A (By similarity)."},{"id":"ENSMUSP00000109160","abundance":0.24,"rank":15458,"name":"Hmcn2","annotation":"Hemicentin-2."},{"id":"ENSMUSP00000003850","abundance":0.24,"rank":15459,"name":"Itpkc","annotation":"Inositol-trisphosphate 3-kinase C; Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate."},{"id":"ENSMUSP00000075170","abundance":0.24,"rank":15460,"name":"Drd2","annotation":"D(2) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000039653","abundance":0.239,"rank":15461,"name":"Nodal","annotation":"Nodal; Essential for mesoderm formation and axial patterning during embryonic development; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000125718","abundance":0.239,"rank":15462,"name":"Fer1l6","annotation":"Fer-1-like 6 (C. elegans)."},{"id":"ENSMUSP00000028880","abundance":0.239,"rank":15463,"name":"Slc20a1","annotation":"Sodium-dependent phosphate transporter 1; Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification."},{"id":"ENSMUSP00000142322","abundance":0.239,"rank":15464,"name":"Astn1","annotation":"Astrotactin-1; Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development."},{"id":"ENSMUSP00000005601","abundance":0.239,"rank":15465,"name":"Il27ra","annotation":"Interleukin-27 receptor subunit alpha; Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms."},{"id":"ENSMUSP00000021209","abundance":0.239,"rank":15466,"name":"Doc2b","annotation":"Double C2-like domain-containing protein beta; Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium- dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium- triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma memb [...] "},{"id":"ENSMUSP00000024869","abundance":0.239,"rank":15467,"name":"Spast","annotation":"Spastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Severing activity is not dependent on tubulin acetylation or detyrosination (By similarity). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the [...] "},{"id":"ENSMUSP00000136866","abundance":0.239,"rank":15468,"name":"Maml2","annotation":"Mastermind-like transcriptional coactivator 2."},{"id":"ENSMUSP00000006451","abundance":0.239,"rank":15469,"name":"Ttc5","annotation":"Tetratricopeptide repeat protein 5; Adapter protein involved in p53/TP53 response that acts by regulating and mediating the assembly of multi-protein complexes. Required to facilitate the interaction between JMY and p300/EP300 and increase p53/TP53-dependent transcription and apoptosis. Prevents p53/TP53 degradation by MDM2."},{"id":"ENSMUSP00000126979","abundance":0.239,"rank":15470,"name":"Vmn2r53","annotation":"Vomeronasal 2, receptor 53."},{"id":"ENSMUSP00000132008","abundance":0.239,"rank":15471,"name":"Arhgap8","annotation":"Rho GTPase-activating protein 8; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state."},{"id":"ENSMUSP00000070533","abundance":0.238,"rank":15472,"name":"Cfap58","annotation":"Cilia- and flagella-associated protein 58."},{"id":"ENSMUSP00000057573","abundance":0.238,"rank":15473,"name":"Fbxo31","annotation":"F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity); Belongs to the FBXO31 family."},{"id":"ENSMUSP00000129762","abundance":0.238,"rank":15474,"name":"Vmn2r105","annotation":"Vomeronasal 2, receptor 105."},{"id":"ENSMUSP00000065783","abundance":0.238,"rank":15475,"name":"Adam39","annotation":"A disintegrin and metallopeptidase domain 39."},{"id":"ENSMUSP00000093833","abundance":0.238,"rank":15476,"name":"Gm5458","annotation":"Predicted gene 5458."},{"id":"ENSMUSP00000136511","abundance":0.238,"rank":15477,"name":"Gm3029","annotation":"Predicted gene 3029."},{"id":"ENSMUSP00000062992","abundance":0.238,"rank":15478,"name":"Npas4","annotation":"Neuronal PAS domain-containing protein 4; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activ [...] "},{"id":"ENSMUSP00000126157","abundance":0.238,"rank":15479,"name":"B3gnt5","annotation":"Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase; Beta-1,3-N-acetylglucosaminyltransferase that plays a key role in the synthesis of lacto- or neolacto-series carbohydrate chains on glycolipids, notably by participating in biosynthesis of HNK-1 and Lewis X carbohydrate structures. Has strong activity toward lactosylceramide (LacCer) and neolactotetraosylceramide (nLc(4)Cer; paragloboside), resulting in the synthesis of Lc(3)Cer and neolactopentaosylceramide (nLc(5)Cer), respectively. Plays a central role in regulating neolacto-series glycolipid synthesis during embryonic de [...] "},{"id":"ENSMUSP00000108166","abundance":0.238,"rank":15480,"name":"4930522L14Rik","annotation":"RIKEN cDNA 4930522L14 gene."},{"id":"ENSMUSP00000003312","abundance":0.238,"rank":15481,"name":"Edar","annotation":"Tumor necrosis factor receptor superfamily member EDAR; Receptor for EDA isoform TAA, but not for EDA isoform TA-2 (By similarity). May mediate the activation of NF-kappa-B and JNK. May promote caspase-independent cell death."},{"id":"ENSMUSP00000068731","abundance":0.237,"rank":15482,"name":"Rgs14","annotation":"Regulator of G-protein signaling 14; Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pa [...] "},{"id":"ENSMUSP00000006037","abundance":0.237,"rank":15483,"name":"Ncoa2","annotation":"Nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by [...] "},{"id":"ENSMUSP00000023048","abundance":0.237,"rank":15484,"name":"Mief1","annotation":"Mitochondrial dynamics protein MID51; Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assem [...] "},{"id":"ENSMUSP00000086752","abundance":0.237,"rank":15485,"name":"Prss55","annotation":"Serine protease 55; Probable serine protease; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000051853","abundance":0.237,"rank":15486,"name":"Ccdc9b","annotation":"Coiled-coil domain-containing protein 9B."},{"id":"ENSMUSP00000019248","abundance":0.237,"rank":15487,"name":"Cd22","annotation":"B-cell receptor CD22; Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also ac [...] "},{"id":"ENSMUSP00000096880","abundance":0.236,"rank":15488,"name":"Pdzd8","annotation":"PDZ domain-containing protein 8; Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer. In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons."},{"id":"ENSMUSP00000151108","abundance":0.236,"rank":15489,"name":"Olfr771","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000076213","abundance":0.236,"rank":15490,"name":"Piwil4","annotation":"Piwi-like protein 4; Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated  [...] "},{"id":"ENSMUSP00000109510","abundance":0.236,"rank":15491,"name":"Arhgef9","annotation":"Rho guanine nucleotide exchange factor 9; Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity)."},{"id":"ENSMUSP00000023958","abundance":0.236,"rank":15492,"name":"P3h3","annotation":"Prolyl 3-hydroxylase 3; Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils. Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea. Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Apparently not required for normal prolyl 3-hydroxylation on collagen chains, possibly because it function [...] "},{"id":"ENSMUSP00000026573","abundance":0.236,"rank":15493,"name":"Lmntd2","annotation":"Lamin tail domain-containing protein 2."},{"id":"ENSMUSP00000158214","abundance":0.236,"rank":15494,"name":"Pggt1b","annotation":"Geranylgeranyl transferase type-1 subunit beta; Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B (By similarity); Belongs to the protein prenyltransferase subunit beta family."},{"id":"ENSMUSP00000109728","abundance":0.236,"rank":15495,"name":"Mdh1b","annotation":"Putative malate dehydrogenase 1B; Belongs to the LDH/MDH superfamily. MDH type 2 family."},{"id":"ENSMUSP00000031366","abundance":0.235,"rank":15496,"name":"Kntc1","annotation":"Kinetochore-associated protein 1; Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (By similarity)."},{"id":"ENSMUSP00000020027","abundance":0.235,"rank":15497,"name":"Serinc1","annotation":"Serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids; Belongs to the TDE1 family."},{"id":"ENSMUSP00000134479","abundance":0.235,"rank":15498,"name":"D7Ertd443e","annotation":"(E2-independent) E3 ubiquitin-conjugating enzyme FATS; Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein s [...] "},{"id":"ENSMUSP00000040171","abundance":0.235,"rank":15499,"name":"Adamts2","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity)."},{"id":"ENSMUSP00000105168","abundance":0.235,"rank":15500,"name":"Atp6ap1l","annotation":"ATPase, H+-transporting, lysosomal accessory protein 1-like."},{"id":"ENSMUSP00000034854","abundance":0.235,"rank":15501,"name":"Chrnb4","annotation":"Neuronal acetylcholine receptor subunit beta-4; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub- subfamily."},{"id":"ENSMUSP00000060199","abundance":0.235,"rank":15502,"name":"4932438A13Rik","annotation":"Transmembrane protein KIAA1109."},{"id":"ENSMUSP00000158825","abundance":0.235,"rank":15503,"name":"Ccdc30","annotation":"Coiled-coil domain-containing protein 30."},{"id":"ENSMUSP00000118907","abundance":0.235,"rank":15504,"name":"Lipo2","annotation":"Lipase; Belongs to the AB hydrolase superfamily. Lipase family."},{"id":"ENSMUSP00000107499","abundance":0.235,"rank":15505,"name":"Pik3c2g","annotation":"Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis."},{"id":"ENSMUSP00000040370","abundance":0.235,"rank":15506,"name":"Fut11","annotation":"Alpha-(1,3)-fucosyltransferase 11; Probable fucosyltransferase; Belongs to the glycosyltransferase 10 family."},{"id":"ENSMUSP00000096963","abundance":0.234,"rank":15507,"name":"Slc4a11","annotation":"Sodium bicarbonate transporter-like protein 11; Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into th [...] "},{"id":"ENSMUSP00000026273","abundance":0.234,"rank":15508,"name":"Slc6a20b","annotation":"Sodium- and chloride-dependent transporter XTRP3B; Does not show transporter activity with a range of tested amino acids including proline, glutamine, glutamic acid, leucine, alanine, histidine, glycine and arginine. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily."},{"id":"ENSMUSP00000159208","abundance":0.234,"rank":15509,"name":"ENSMUSP00000159208","annotation":"Novel protein."},{"id":"ENSMUSP00000069539","abundance":0.234,"rank":15510,"name":"Cpt1c","annotation":"Carnitine O-palmitoyltransferase 1, brain isoform; May play a role in lipid metabolic process. Belongs to the carnitine/choline acetyltransferase family."},{"id":"ENSMUSP00000092048","abundance":0.234,"rank":15511,"name":"Insm1","annotation":"Insulinoma-associated protein 1; Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle- independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses ta [...] "},{"id":"ENSMUSP00000150268","abundance":0.234,"rank":15512,"name":"Olfr224","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000105207","abundance":0.234,"rank":15513,"name":"Mrtfa","annotation":"Myocardin-related transcription factor A; Transcription coactivator that associates with the serum response factor (SRF) transcription factor to control expression of genes regulating the cytoskeleton during development, morphogenesis and cell migration. The SRF-MRTFA complex activity responds to Rho GTPase-induced changes in cellular globular actin (G- actin) concentration, thereby coupling cytoskeletal gene expression to cytoskeletal dynamics. MRTFA binds G-actin via its RPEL repeats, regulating activity of the MRTFA-SRF complex. Activity is also regulated by filamentous actin (F-act [...] "},{"id":"ENSMUSP00000033560","abundance":0.233,"rank":15514,"name":"Ophn1","annotation":"Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals (By similarity). Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation."},{"id":"ENSMUSP00000033581","abundance":0.233,"rank":15515,"name":"Fgf16","annotation":"Fibroblast growth factor 16; Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development."},{"id":"ENSMUSP00000136168","abundance":0.233,"rank":15516,"name":"4933409K07Rik","annotation":"annotation not available"},{"id":"ENSMUSP00000071521","abundance":0.233,"rank":15517,"name":"Prmt7","annotation":"Protein arginine N-methyltransferase 7; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being [...] "},{"id":"ENSMUSP00000026896","abundance":0.233,"rank":15518,"name":"St8sia2","annotation":"Alpha-2,8-sialyltransferase 8B; May transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked and alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins and may be involved in PSA (polysialic acid) expression; Belongs to the glycosyltransferase 29 family."},{"id":"ENSMUSP00000028577","abundance":0.233,"rank":15519,"name":"A26c3","annotation":"ANKRD26-like family C, member 3."},{"id":"ENSMUSP00000010804","abundance":0.233,"rank":15520,"name":"Plcd1","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development."},{"id":"ENSMUSP00000118257","abundance":0.233,"rank":15521,"name":"Apol6","annotation":"Apolipoprotein L 6."},{"id":"ENSMUSP00000113561","abundance":0.232,"rank":15522,"name":"Zfp534","annotation":"Zinc finger protein 534."},{"id":"ENSMUSP00000104116","abundance":0.232,"rank":15523,"name":"Ctns","annotation":"Cystinosin; Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR; Belongs to the cystinosin family."},{"id":"ENSMUSP00000146795","abundance":0.232,"rank":15524,"name":"Psg22","annotation":"Pregnancy-specific glycoprotein 22; May have an angiogenic function during early placental development. Binds to cell-surface heparan sulfate proteoglycans (HSPGs), and stimulates secretion of the proangiogenic factors VEGFA and TGFB from uterine dendritic cells and natural killer cells. Also induces endothelial tube formation in vitro."},{"id":"ENSMUSP00000007171","abundance":0.232,"rank":15525,"name":"Chrd","annotation":"Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes."},{"id":"ENSMUSP00000025521","abundance":0.232,"rank":15526,"name":"Cdx1","annotation":"Homeobox protein CDX-1; Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA; Belongs to the Caudal homeobox family."},{"id":"ENSMUSP00000006005","abundance":0.232,"rank":15527,"name":"Pth1r","annotation":"Parathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system."},{"id":"ENSMUSP00000124780","abundance":0.232,"rank":15528,"name":"C87414","annotation":"Expressed sequence C87414."},{"id":"ENSMUSP00000098577","abundance":0.232,"rank":15529,"name":"Gm3259","annotation":"Predicted gene 3259."},{"id":"ENSMUSP00000036289","abundance":0.231,"rank":15530,"name":"Sppl2b","annotation":"Signal peptide peptidase-like 2B; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity; Belongs to the peptidase A22B family."},{"id":"ENSMUSP00000027682","abundance":0.231,"rank":15531,"name":"Gpr37l1","annotation":"G-protein coupled receptor 37-like 1; G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (By similarity). However, other studies have shown that prosaposin does not increase activity (By similarity). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (By similarity). Participates in the regulation of postnatal cerebellar development by modulating the Shh path [...] "},{"id":"ENSMUSP00000076219","abundance":0.231,"rank":15532,"name":"Spry3","annotation":"Sprouty RTK signaling antagonist 3."},{"id":"ENSMUSP00000084319","abundance":0.231,"rank":15533,"name":"Nhs","annotation":"NHS actin-remodeling regulator."},{"id":"ENSMUSP00000097089","abundance":0.231,"rank":15534,"name":"Nsd1","annotation":"Histone-lysine N-methyltransferase, H3 lysine-36 specific; Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development. Belongs to the class V-like SAM-binding methyltransferase superfamily."},{"id":"ENSMUSP00000120413","abundance":0.231,"rank":15535,"name":"Zfp988","annotation":"Zinc finger protein 988."},{"id":"ENSMUSP00000154109","abundance":0.231,"rank":15536,"name":"Vmn1r37","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000033919","abundance":0.23,"rank":15537,"name":"Vegfc","annotation":"Vascular endothelial growth factor C; Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors."},{"id":"ENSMUSP00000111041","abundance":0.23,"rank":15538,"name":"Cped1","annotation":"Cadherin-like and PC-esterase domain-containing 1."},{"id":"ENSMUSP00000143036","abundance":0.23,"rank":15539,"name":"P2ry12","annotation":"P2Y purinoceptor 12; Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation."},{"id":"ENSMUSP00000020227","abundance":0.23,"rank":15540,"name":"Cry1","annotation":"Cryptochrome-1; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal [...] "},{"id":"ENSMUSP00000049162","abundance":0.23,"rank":15541,"name":"Fam117a","annotation":"Protein FAM117A."},{"id":"ENSMUSP00000001484","abundance":0.229,"rank":15542,"name":"Tbx21","annotation":"T-box transcription factor TBX21; Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs. Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4- containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and  [...] "},{"id":"ENSMUSP00000089493","abundance":0.229,"rank":15543,"name":"Zfp987","annotation":"Predicted gene, OTTMUSG00000010173."},{"id":"ENSMUSP00000116437","abundance":0.229,"rank":15544,"name":"Syna","annotation":"Transmembrane protein; This endogenous retroviral envelope protein has retained its original fusogenic properties. Together with Synb, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. Syna is essential for placental development and is specifically required for formation of syncytiotrophoblast layer I (SynT-I). Promotes muscle myoblast fusion. Does not have immunosuppressive activity."},{"id":"ENSMUSP00000034218","abundance":0.229,"rank":15545,"name":"Slc12a3","annotation":"Solute carrier family 12 member 3; Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (By similarity). Receptor for the proinflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2. May act either independently of IL18R1, or in a complex with IL18R1."},{"id":"ENSMUSP00000068738","abundance":0.229,"rank":15546,"name":"Dnah7b","annotation":"Dynein, axonemal, heavy chain 7B."},{"id":"ENSMUSP00000026999","abundance":0.229,"rank":15547,"name":"Smad7","annotation":"Mothers against decapentaplegic homolog 7; Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a  [...] "},{"id":"ENSMUSP00000079840","abundance":0.229,"rank":15548,"name":"Zfp105","annotation":"Zinc finger protein 105."},{"id":"ENSMUSP00000084089","abundance":0.229,"rank":15549,"name":"Pot1b","annotation":"Protection of telomeres 1B."},{"id":"ENSMUSP00000032633","abundance":0.229,"rank":15550,"name":"Oca2","annotation":"P protein; Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the postranslational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. It can modulate intracellular glutathione metabolism; Belongs to the CitM (TC 2.A.11) transporter family."},{"id":"ENSMUSP00000043633","abundance":0.229,"rank":15551,"name":"Tmem132d","annotation":"Transmembrane protein 132D; May serve as a cell-surface marker for oligodendrocyte differentiation."},{"id":"ENSMUSP00000098441","abundance":0.229,"rank":15552,"name":"Gm6588","annotation":"Predicted gene 6588."},{"id":"ENSMUSP00000139398","abundance":0.228,"rank":15553,"name":"Col6a5","annotation":"Collagen alpha-5(VI) chain; Collagen VI acts as a cell-binding protein."},{"id":"ENSMUSP00000130311","abundance":0.228,"rank":15554,"name":"Cphx2","annotation":"Cytoplasmic polyadenylated homeobox 1."},{"id":"ENSMUSP00000139300","abundance":0.228,"rank":15555,"name":"Cphx3","annotation":"Cytoplasmic polyadenylated homeobox 3."},{"id":"ENSMUSP00000139237","abundance":0.228,"rank":15556,"name":"Cphx1","annotation":"Cytoplasmic polyadenylated homeobox 1."},{"id":"ENSMUSP00000050377","abundance":0.228,"rank":15557,"name":"Actrt2","annotation":"Actin-related protein T2."},{"id":"ENSMUSP00000104732","abundance":0.228,"rank":15558,"name":"Maf","annotation":"Transcription factor Maf; Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters (By similarity). Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T hel [...] "},{"id":"ENSMUSP00000020707","abundance":0.228,"rank":15559,"name":"Gabra1","annotation":"Gamma-aminobutyric acid receptor subunit alpha-1; Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The a [...] "},{"id":"ENSMUSP00000132906","abundance":0.228,"rank":15560,"name":"Dbf4","annotation":"Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role DNA in replication and cell proliferation. Required for progression of S phase. The complex CDC7- DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle."},{"id":"ENSMUSP00000103897","abundance":0.228,"rank":15561,"name":"Samd7","annotation":"Sterile alpha motif domain-containing protein 7; Involved in the regulation of gene expression in the retina. It functions as a negative regulator of CRX-controlled genes."},{"id":"ENSMUSP00000030165","abundance":0.227,"rank":15562,"name":"Fancg","annotation":"Fanconi anemia group G protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene (By similarity)."},{"id":"ENSMUSP00000034508","abundance":0.227,"rank":15563,"name":"Usp2","annotation":"Ubiquitin carboxyl-terminal hydrolase 2; Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (By similarity). Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity). Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (By similarity). Has no deubiquitinase activity against p53/TP53 (By similarity). Prevents MDM2-mediated degradation of MDM4 (By similarity). Plays a role in the G1/S cell-cycle  [...] "},{"id":"ENSMUSP00000047334","abundance":0.227,"rank":15564,"name":"Wdr60","annotation":"WD repeat-containing protein 60; May play a role in ciliogenesis."},{"id":"ENSMUSP00000133483","abundance":0.227,"rank":15565,"name":"Vmn2r55","annotation":"Vomeronasal 2, receptor 55; Belongs to the G-protein coupled receptor 3 family."},{"id":"ENSMUSP00000025262","abundance":0.227,"rank":15566,"name":"Ltb","annotation":"Lymphotoxin-beta; Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface."},{"id":"ENSMUSP00000151295","abundance":0.227,"rank":15567,"name":"Olfr692","annotation":"Olfactory receptor MOR36-1."},{"id":"ENSMUSP00000147714","abundance":0.227,"rank":15568,"name":"Gm45861","annotation":"Predicted gene 45861."},{"id":"ENSMUSP00000038783","abundance":0.227,"rank":15569,"name":"Enc1","annotation":"Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down- regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism (By similarity)."},{"id":"ENSMUSP00000128458","abundance":0.227,"rank":15570,"name":"Gm3460","annotation":"Predicted gene 3460."},{"id":"ENSMUSP00000121642","abundance":0.226,"rank":15571,"name":"Ssxb6","annotation":"Synovial sarcoma, X member B6."},{"id":"ENSMUSP00000097507","abundance":0.226,"rank":15572,"name":"Fads2b","annotation":"Fatty acid desaturase 2-like protein FADS2P1."},{"id":"ENSMUSP00000100068","abundance":0.226,"rank":15573,"name":"Ssxb10","annotation":"Synovial sarcoma, X member B10."},{"id":"ENSMUSP00000065363","abundance":0.226,"rank":15574,"name":"Nfil3","annotation":"Nuclear factor interleukin-3-regulated protein; Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites (By similarity). Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B- site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells (By similarity). Competes for the same consens [...] "},{"id":"ENSMUSP00000058783","abundance":0.226,"rank":15575,"name":"Fads6","annotation":"Fatty acid desaturase 6."},{"id":"ENSMUSP00000147534","abundance":0.226,"rank":15576,"name":"Gm35315","annotation":"Zinc finger protein."},{"id":"ENSMUSP00000006378","abundance":0.226,"rank":15577,"name":"Clcnkb","annotation":"Chloride channel protein ClC-Kb; Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. May be the basolateral chloride channel mediating net chloride absorption in CTAL cells; Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily."},{"id":"ENSMUSP00000026159","abundance":0.226,"rank":15578,"name":"Cd7","annotation":"T-cell antigen CD7; Not yet known."},{"id":"ENSMUSP00000142210","abundance":0.226,"rank":15579,"name":"Fcrl5","annotation":"Fc receptor-like protein 5."},{"id":"ENSMUSP00000155019","abundance":0.226,"rank":15580,"name":"Amigo2","annotation":"Amphoterin-induced protein 2; Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity); Belongs to the immunoglobulin superfamily. AMIGO family."},{"id":"ENSMUSP00000036801","abundance":0.225,"rank":15581,"name":"Ctsll3","annotation":"Cathepsin L-like 3; Belongs to the peptidase C1 family."},{"id":"ENSMUSP00000128141","abundance":0.225,"rank":15582,"name":"Fancb","annotation":"Fanconi anemia group B protein homolog; DNA repair protein required for FANCD2 ubiquitination."},{"id":"ENSMUSP00000111229","abundance":0.225,"rank":15583,"name":"Nr3c1","annotation":"Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] "},{"id":"ENSMUSP00000045367","abundance":0.225,"rank":15584,"name":"Dennd2a","annotation":"DENN domain-containing protein 2A; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport (By similarity)."},{"id":"ENSMUSP00000054747","abundance":0.225,"rank":15585,"name":"Dpy19l3","annotation":"Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family."},{"id":"ENSMUSP00000044831","abundance":0.225,"rank":15586,"name":"Atrip","annotation":"ATR-interacting protein; Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein (By similarity); Belongs to the ATRIP family."},{"id":"ENSMUSP00000098217","abundance":0.225,"rank":15587,"name":"Gtf2ird1","annotation":"General transcription factor II-I repeat domain-containing protein 1; May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow- twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8; Belongs to the TFII-I family."},{"id":"ENSMUSP00000060949","abundance":0.225,"rank":15588,"name":"Pcdhgc5","annotation":"Protocadherin gamma subfamily C, 5."},{"id":"ENSMUSP00000139354","abundance":0.224,"rank":15589,"name":"Fam83b","annotation":"Protein FAM83B; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades."},{"id":"ENSMUSP00000142140","abundance":0.224,"rank":15590,"name":"Pcdhga4","annotation":"Protocadherin gamma-A4; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain (By similarity)."},{"id":"ENSMUSP00000016110","abundance":0.224,"rank":15591,"name":"Il17rb","annotation":"Interleukin-17 receptor B; Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells."},{"id":"ENSMUSP00000042927","abundance":0.224,"rank":15592,"name":"Dner","annotation":"Delta and Notch-like epidermal growth factor-related receptor; Mediates neuron-glia interaction during astrocytogenesis. May promote differentiation of Bergmann glia during cerebellar development by activating DELTEX-dependent NOTCH1 signaling."},{"id":"ENSMUSP00000151834","abundance":0.224,"rank":15593,"name":"Olfr832","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000075814","abundance":0.224,"rank":15594,"name":"Slc22a21","annotation":"Solute carrier family 22 member 21; Sodium-ion independent, medium affinity carnitine transporter. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 746."},{"id":"ENSMUSP00000080440","abundance":0.224,"rank":15595,"name":"Olfr331","annotation":"Olfactory receptor 331."},{"id":"ENSMUSP00000043966","abundance":0.223,"rank":15596,"name":"Arsi","annotation":"Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts; Belongs to the sulfatase family."},{"id":"ENSMUSP00000047954","abundance":0.223,"rank":15597,"name":"Cyp24a1","annotation":"1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial; A cytochrome P450 monooxygenase with a key role in vitamin D catabolism and calcium homeostasis. Via C24-oxidation pathway, catalyzes the inactivation of both the vitamin D precursor calcidiol (25-hydroxyvitamin D(3)) and the active hormone calcitriol (1-alpha,25- dihydroxyvitamin D(3)). With initial hydroxylation at C-24 (via C24- oxidation pathway), performs a sequential 6-step oxidation of calcitriol leading to the formation of the biliary metabolite calcitroic acid. Hydroxylates at C-24 or C-25 other vitamin D active metabol [...] "},{"id":"ENSMUSP00000122894","abundance":0.223,"rank":15598,"name":"Ccser1","annotation":"Serine-rich coiled-coil domain-containing protein 1."},{"id":"ENSMUSP00000058575","abundance":0.223,"rank":15599,"name":"Foxd4","annotation":"Forkhead box protein D4."},{"id":"ENSMUSP00000063276","abundance":0.223,"rank":15600,"name":"Gabra5","annotation":"Gamma-aminobutyric acid receptor subunit alpha-5; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub- subfamily."},{"id":"ENSMUSP00000029562","abundance":0.223,"rank":15601,"name":"Chrnb2","annotation":"Neuronal acetylcholine receptor subunit beta-2; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions."},{"id":"ENSMUSP00000027165","abundance":0.223,"rank":15602,"name":"Cd28","annotation":"T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation."},{"id":"ENSMUSP00000139117","abundance":0.223,"rank":15603,"name":"Lzts1","annotation":"Leucine zipper putative tumor suppressor 1; Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity). Belongs to the LZTS family."},{"id":"ENSMUSP00000090143","abundance":0.222,"rank":15604,"name":"Adamts14","annotation":"A Disintegrin-like and metallopeptidase (Reprolysin type) with thrombospondin type 1 motif, 14."},{"id":"ENSMUSP00000113398","abundance":0.222,"rank":15605,"name":"Rgs20","annotation":"Regulator of G-protein signaling 20; Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)- i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins."},{"id":"ENSMUSP00000092993","abundance":0.222,"rank":15606,"name":"Aebp2","annotation":"Zinc finger protein AEBP2; May interact with and stimulate the activity of the PRC2 complex, which methylates 'Lys-9' and 'Lys-27' residues of histone H3 (By similarity). DNA-binding transcriptional repressor."},{"id":"ENSMUSP00000111199","abundance":0.222,"rank":15607,"name":"Col28a1","annotation":"Collagen alpha-1(XXVIII) chain; May act as a cell-binding protein; Belongs to the VWA-containing collagen family."},{"id":"ENSMUSP00000108107","abundance":0.222,"rank":15608,"name":"Cd55b","annotation":"Complement decay-accelerating factor transmembrane isoform; This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing th [...] "},{"id":"ENSMUSP00000134661","abundance":0.222,"rank":15609,"name":"Pax2","annotation":"Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation."},{"id":"ENSMUSP00000080066","abundance":0.221,"rank":15610,"name":"Sfi1","annotation":"Protein SFI1 homolog; Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2."},{"id":"ENSMUSP00000057488","abundance":0.221,"rank":15611,"name":"Dmrta1","annotation":"Doublesex- and mab-3-related transcription factor A1; Belongs to the DMRT family."},{"id":"ENSMUSP00000033738","abundance":0.221,"rank":15612,"name":"Trex2","annotation":"Three prime repair exonuclease 2; Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair."},{"id":"ENSMUSP00000004684","abundance":0.22,"rank":15613,"name":"Arhgef18","annotation":"Rho guanine nucleotide exchange factor 18; Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape cha [...] "},{"id":"ENSMUSP00000075195","abundance":0.22,"rank":15614,"name":"Fthl17c","annotation":"Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation."},{"id":"ENSMUSP00000100623","abundance":0.22,"rank":15615,"name":"Fthl17b","annotation":"Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation."},{"id":"ENSMUSP00000025019","abundance":0.22,"rank":15616,"name":"Arhgdig","annotation":"Rho GDP-dissociation inhibitor 3; Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP."},{"id":"ENSMUSP00000138090","abundance":0.22,"rank":15617,"name":"Ccdc154","annotation":"Coiled-coil domain-containing protein 154."},{"id":"ENSMUSP00000040584","abundance":0.22,"rank":15618,"name":"Iqcc","annotation":"IQ domain-containing protein C."},{"id":"ENSMUSP00000093958","abundance":0.22,"rank":15619,"name":"Tut1","annotation":"Speckle targeted PIP5K1A-regulated poly(A) polymerase; Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher tha [...] "},{"id":"ENSMUSP00000091329","abundance":0.22,"rank":15620,"name":"Filip1","annotation":"Filamin-A-interacting protein 1; By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A."},{"id":"ENSMUSP00000138087","abundance":0.219,"rank":15621,"name":"Zfp87","annotation":"Zinc finger protein 87."},{"id":"ENSMUSP00000091163","abundance":0.219,"rank":15622,"name":"Ell","annotation":"RNA polymerase II elongation factor ELL; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-i [...] "},{"id":"ENSMUSP00000058183","abundance":0.219,"rank":15623,"name":"Gpr101","annotation":"Probable G-protein coupled receptor 101; Orphan receptor."},{"id":"ENSMUSP00000030010","abundance":0.219,"rank":15624,"name":"Abca1","annotation":"Phospholipid-transporting ATPase ABCA1; Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates to phospholipids transfer to apoliproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apoliproteins and the formation of nascent high density lipoproteins/HDLs; Belongs to the ABC transporter superfamily. ABCA family."},{"id":"ENSMUSP00000047838","abundance":0.218,"rank":15625,"name":"Tbc1d25","annotation":"TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes."},{"id":"ENSMUSP00000020586","abundance":0.218,"rank":15626,"name":"Slc22a4","annotation":"Solute carrier family 22 member 4; Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78; Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family."},{"id":"ENSMUSP00000057859","abundance":0.218,"rank":15627,"name":"Dgkq","annotation":"Diacylglycerol kinase theta; Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor (By similarity). May be involved in cAMP-induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity (By similarity)."},{"id":"ENSMUSP00000041939","abundance":0.217,"rank":15628,"name":"Adgrl4","annotation":"Adhesion G protein-coupled receptor L4; Endothelial orphan receptor that acts as a key regulator of angiogenesis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily."},{"id":"ENSMUSP00000035650","abundance":0.217,"rank":15629,"name":"Glis1","annotation":"Zinc finger protein GLIS1; Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'. By controlling the expression of genes involved in cell differentiation inhibits the lineage commitment of multipotent cells. Prevents, for instance, the differentiation of multipotent mesenchymal cells into adipocyte and osteoblast. Belongs to the GLI C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000113303","abundance":0.217,"rank":15630,"name":"Cdkl3","annotation":"Cyclin-dependent kinase-like 3."},{"id":"ENSMUSP00000055750","abundance":0.217,"rank":15631,"name":"Ranbp3l","annotation":"Ran-binding protein 3-like; Nuclear export factor for BMP-specific SMAD1/5/8 that plays a critical role in terminating BMP signaling and regulating mesenchymal stem cell differentiation by blocking osteoblast differentiation to promote myogenic differention. Directly recognizes dephosphorylated SMAD1/5/8 and mediates their nuclear export in a Ran-dependent manner."},{"id":"ENSMUSP00000040019","abundance":0.217,"rank":15632,"name":"Piezo2","annotation":"Piezo-type mechanosensitive ion channel component 2; Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation ; Belongs to the PIEZO (TC 1.A.75) family."},{"id":"ENSMUSP00000071085","abundance":0.217,"rank":15633,"name":"BC049762","annotation":"cDNA sequence BC049762."},{"id":"ENSMUSP00000043077","abundance":0.217,"rank":15634,"name":"Mgat3","annotation":"Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conform [...] "},{"id":"ENSMUSP00000053547","abundance":0.217,"rank":15635,"name":"Bicdl1","annotation":"BICD family-like cargo adapter 1; Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6- containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis."},{"id":"ENSMUSP00000147463","abundance":0.217,"rank":15636,"name":"Sorcs1","annotation":"VPS10 domain-containing receptor SorCS1."},{"id":"ENSMUSP00000108801","abundance":0.217,"rank":15637,"name":"Pramel3","annotation":"Preferentially-expressed antigen in melanoma-like 3."},{"id":"ENSMUSP00000129566","abundance":0.217,"rank":15638,"name":"Vmn2r56","annotation":"Vomeronasal 2, receptor 56."},{"id":"ENSMUSP00000071904","abundance":0.216,"rank":15639,"name":"Alms1","annotation":"Alstrom syndrome protein 1 homolog; Involved in PCM1-dependent intracellular transport. Required, directly or indirectly, for the localization of NCAPD2 to the proximal ends of centrioles. Required for proper formation and/or maintenance of primary cilia (PC), microtubule-based structures that protrude from the surface of epithelial cells (By similarity)."},{"id":"ENSMUSP00000052113","abundance":0.216,"rank":15640,"name":"Pcdhb18","annotation":"Protocadherin beta-18; Potential calcium-dependent cell-adhesion protein."},{"id":"ENSMUSP00000059291","abundance":0.216,"rank":15641,"name":"Depdc1b","annotation":"DEP domain-containing protein 1B."},{"id":"ENSMUSP00000133281","abundance":0.216,"rank":15642,"name":"Hoxb6","annotation":"Homeobox protein Hox-B6; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family."},{"id":"ENSMUSP00000028346","abundance":0.216,"rank":15643,"name":"Fam166a","annotation":"Protein FAM166A; Belongs to the UPF0605 family."},{"id":"ENSMUSP00000025471","abundance":0.216,"rank":15644,"name":"Il17b","annotation":"Interleukin-17B; Stimulates the release of tumor necrosis factor alpha and IL- 1-beta from the monocytic cell line THP-1; Belongs to the IL-17 family."},{"id":"ENSMUSP00000149649","abundance":0.216,"rank":15645,"name":"Olfr1184","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000145386","abundance":0.216,"rank":15646,"name":"Olfr325","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000061919","abundance":0.216,"rank":15647,"name":"Tmtc2","annotation":"Protein O-mannosyl-transferase TMTC2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl- transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O- mannosyl-transferase on other proteins such as PDIA3."},{"id":"ENSMUSP00000040309","abundance":0.216,"rank":15648,"name":"Larp6","annotation":"La-related protein 6; Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9 (By similarity)."},{"id":"ENSMUSP00000130005","abundance":0.215,"rank":15649,"name":"Cyp27b1","annotation":"25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial; A cytochrome P450 monooxygenase involved in vitamin D metabolism and in calcium and phosphorus homeostasis. Catalyzes the rate-limiting step in the activation of vitamin D in the kidney, namely the hydroxylation of 25-hydroxyvitamin D3/calcidiol at the C1-alpha position to form the hormonally active form of vitamin D3, 1alpha,25- dihydroxyvitamin D3/calcitriol that acts via the vitamin D receptor (VDR). Has 1-alpha-hydroxylase activity on vitamin D intermediates of the CYP24A1-mediated inactivation pathway. Converts 24R,25-dihydro [...] "},{"id":"ENSMUSP00000029139","abundance":0.215,"rank":15650,"name":"Trim55","annotation":"Tripartite motif-containing 55."},{"id":"ENSMUSP00000133159","abundance":0.215,"rank":15651,"name":"Pdzrn4","annotation":"PDZ domain-containing RING finger 4."},{"id":"ENSMUSP00000003369","abundance":0.215,"rank":15652,"name":"Plag1","annotation":"Zinc finger protein PLAG1; Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Cooperates with CBFB-MYH11. Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000151202","abundance":0.215,"rank":15653,"name":"Olfr344","annotation":"Olfactory receptor MOR136-12."},{"id":"ENSMUSP00000083459","abundance":0.214,"rank":15654,"name":"Zfp810","annotation":"Zinc finger protein 810."},{"id":"ENSMUSP00000153548","abundance":0.214,"rank":15655,"name":"Zscan12","annotation":"Zinc finger and SCAN domain-containing protein 12; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000023747","abundance":0.214,"rank":15656,"name":"Nckap5l","annotation":"Nck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L- mediated microtubule bundle formation."},{"id":"ENSMUSP00000068516","abundance":0.214,"rank":15657,"name":"Mapkbp1","annotation":"Mitogen-activated protein kinase-binding protein 1; Negative regulator of NOD2 function. It down-regulates NOD2- induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (By similarity). Involved in JNK signaling pathway."},{"id":"ENSMUSP00000112659","abundance":0.214,"rank":15658,"name":"Prss36","annotation":"Polyserase-2; Serine protease. Hydrolyzes the peptides N-t-Boc-Gln-Ala-Arg- AMC and N-t-Boc-Gln-Gly-Arg-AMC and, to a lesser extent, N-t-Boc-Ala- Phe-Lys-AMC and N-t-Boc-Val-Leu-Lys-AMC. Has a preference for substrates with an Arg instead of a Lys residue in position P1 (By similarity); Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000003898","abundance":0.214,"rank":15659,"name":"Ece2","annotation":"Endothelin-converting enzyme 2; Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides (By similarity). May play a role in amyloid-beta processing. Belongs to the peptidase M13 family."},{"id":"ENSMUSP00000038947","abundance":0.213,"rank":15660,"name":"Prrg3","annotation":"Transmembrane gamma-carboxyglutamic acid protein 3."},{"id":"ENSMUSP00000010941","abundance":0.213,"rank":15661,"name":"Wnt2","annotation":"Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons."},{"id":"ENSMUSP00000150542","abundance":0.213,"rank":15662,"name":"Olfr348","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000023812","abundance":0.213,"rank":15663,"name":"Map3k12","annotation":"Mitogen-activated protein kinase kinase kinase 12; Protein kinase which is part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway."},{"id":"ENSMUSP00000150908","abundance":0.213,"rank":15664,"name":"Olfr172","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000077389","abundance":0.213,"rank":15665,"name":"Pcdhb5","annotation":"Protocadherin beta 5."},{"id":"ENSMUSP00000060225","abundance":0.213,"rank":15666,"name":"Snx33","annotation":"Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macr [...] "},{"id":"ENSMUSP00000090395","abundance":0.213,"rank":15667,"name":"5430403G16Rik","annotation":"RIKEN cDNA 5430403G16 gene."},{"id":"ENSMUSP00000060157","abundance":0.213,"rank":15668,"name":"Rtl3","annotation":"Retrotransposon Gag-like protein 3; May function as a transcriptional regulator (Probable). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal."},{"id":"ENSMUSP00000112959","abundance":0.213,"rank":15669,"name":"Nrip1","annotation":"Nuclear receptor-interacting protein 1; Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development."},{"id":"ENSMUSP00000088324","abundance":0.213,"rank":15670,"name":"Gm128","annotation":"Protein MENT; Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B."},{"id":"ENSMUSP00000137367","abundance":0.213,"rank":15671,"name":"Sncaip","annotation":"Synphilin-1."},{"id":"ENSMUSP00000136328","abundance":0.213,"rank":15672,"name":"Fzd6","annotation":"Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] "},{"id":"ENSMUSP00000112436","abundance":0.212,"rank":15673,"name":"Cacna1a","annotation":"Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. P/Q-type calcium channels belong to the 'high- voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P54282) (By similarity). [...] "},{"id":"ENSMUSP00000030408","abundance":0.212,"rank":15674,"name":"Mfsd2a","annotation":"Sodium-dependent lysophosphatidylcholine symporter 1; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long- chain fatty acids such LPC oleate and L [...] "},{"id":"ENSMUSP00000065787","abundance":0.212,"rank":15675,"name":"Dnaic2","annotation":"Dynein intermediate chain 2, axonemal; Part of the dynein complex of respiratory cilia."},{"id":"ENSMUSP00000136881","abundance":0.212,"rank":15676,"name":"Ighv6-4","annotation":"Immunoglobulin heavy variable V6-4."},{"id":"ENSMUSP00000032701","abundance":0.212,"rank":15677,"name":"Tdrd12","annotation":"Putative ATP-dependent RNA helicase TDRD12; Probable ATP-binding RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process. Acts via the PET complex, a multiprotein complex required during the secondary  [...] "},{"id":"ENSMUSP00000016172","abundance":0.211,"rank":15678,"name":"Celsr1","annotation":"Cadherin EGF LAG seven-pass G-type receptor 1; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily."},{"id":"ENSMUSP00000033646","abundance":0.211,"rank":15679,"name":"Il13ra2","annotation":"Interleukin-13 receptor subunit alpha-2; Binds as a monomer with high affinity to interleukin-13 (IL13); Belongs to the type I cytokine receptor family. Type 5 subfamily."},{"id":"ENSMUSP00000075063","abundance":0.211,"rank":15680,"name":"Ptpn3","annotation":"Tyrosine-protein phosphatase non-receptor type 3; May act at junctions between the membrane and the cytoskeleton."},{"id":"ENSMUSP00000074290","abundance":0.211,"rank":15681,"name":"Dgkh","annotation":"Diacylglycerol kinase."},{"id":"ENSMUSP00000028780","abundance":0.211,"rank":15682,"name":"Chac1","annotation":"Glutathione-specific gamma-glutamylcyclotransferase 1; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, [...] "},{"id":"ENSMUSP00000112494","abundance":0.211,"rank":15683,"name":"Zfp607b","annotation":"Zinc finger protein 607B."},{"id":"ENSMUSP00000130981","abundance":0.211,"rank":15684,"name":"Hlcs","annotation":"Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Biotin--protein ligase catalyzing the biotinylation of the 4 biotin-dependent carboxylases acetyl-CoA-carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, and methylcrotonyl-CoA carboxylase."},{"id":"ENSMUSP00000094390","abundance":0.211,"rank":15685,"name":"Nutm2","annotation":"NUT family member 2; Belongs to the NUT family."},{"id":"ENSMUSP00000051794","abundance":0.211,"rank":15686,"name":"4930563M21Rik","annotation":"RIKEN cDNA 4930563M21 gene."},{"id":"ENSMUSP00000119721","abundance":0.211,"rank":15687,"name":"Agbl1","annotation":"Cytosolic carboxypeptidase 4; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5."},{"id":"ENSMUSP00000067002","abundance":0.211,"rank":15688,"name":"Pld4","annotation":"5'-3' exonuclease PLD4; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor. Involved in phagocytosis of activated microglia."},{"id":"ENSMUSP00000046172","abundance":0.21,"rank":15689,"name":"AA986860","annotation":"Specifically androgen-regulated gene protein; Putative androgen-specific receptor."},{"id":"ENSMUSP00000092049","abundance":0.21,"rank":15690,"name":"Gm12185","annotation":"Predicted gene 12185."},{"id":"ENSMUSP00000132098","abundance":0.21,"rank":15691,"name":"Gen1","annotation":"Flap endonuclease GEN homolog 1; Endonuclease which resolves Holliday junctions (HJs) by the introduction of symmetrically related cuts across the junction point, to produce nicked duplex products in which the nicks can be readily ligated. Four-way DNA intermediates, also known as Holliday junctions, are formed during homologous recombination and DNA repair, and their resolution is necessary for proper chromosome segregation. Cleaves HJs by a nick and counter-nick mechanism involving dual coordinated incisions that lead to the formation of ligatable nicked duplex products. Cleavage of  [...] "},{"id":"ENSMUSP00000051842","abundance":0.21,"rank":15692,"name":"Jrk","annotation":"Jerky protein; May bind DNA."},{"id":"ENSMUSP00000144157","abundance":0.21,"rank":15693,"name":"Ppef2","annotation":"Serine/threonine-protein phosphatase with EF-hands 2; May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission; Belongs to the PPP phosphatase family."},{"id":"ENSMUSP00000103990","abundance":0.209,"rank":15694,"name":"Hipk4","annotation":"Homeodomain-interacting protein kinase 4; Protein kinase that phosphorylates murine TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter. May act as a corepressor of transcription factors (Potential)."},{"id":"ENSMUSP00000132846","abundance":0.209,"rank":15695,"name":"Fam178b","annotation":"Protein FAM178B."},{"id":"ENSMUSP00000156075","abundance":0.209,"rank":15696,"name":"Map3k13","annotation":"Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB- containing complex that phosphorylates inhibitors of NF-kappa-B (By similarity)."},{"id":"ENSMUSP00000047110","abundance":0.209,"rank":15697,"name":"Zfp938","annotation":"Zinc finger protein 938."},{"id":"ENSMUSP00000035181","abundance":0.209,"rank":15698,"name":"Aste1","annotation":"Protein asteroid homolog 1; Possible role in EGF receptor signaling; Belongs to the asteroid family."},{"id":"ENSMUSP00000157109","abundance":0.208,"rank":15699,"name":"Elp2","annotation":"Elongator complex protein 2; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs."},{"id":"ENSMUSP00000101701","abundance":0.208,"rank":15700,"name":"Nkx6-2","annotation":"NK6 homeobox 2."},{"id":"ENSMUSP00000113681","abundance":0.208,"rank":15701,"name":"Thsd7a","annotation":"Thrombospondin type-1 domain-containing protein 7A, soluble form; [Thrombospondin type-1 domain-containing protein 7A]: Plays a role in actin cytoskeleton rearrangement."},{"id":"ENSMUSP00000021161","abundance":0.208,"rank":15702,"name":"Slc13a5","annotation":"Solute carrier family 13 member 5; High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol (By similarity). Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily."},{"id":"ENSMUSP00000073246","abundance":0.208,"rank":15703,"name":"Mdga1","annotation":"MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex. Plays a role in the formation or maintenance of inhibitory synapses. May function by inhibiting the activity of NLGN2."},{"id":"ENSMUSP00000025036","abundance":0.208,"rank":15704,"name":"Kdm4b","annotation":"Lysine-specific demethylase 4B; Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys- 20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (By similarity)."},{"id":"ENSMUSP00000097565","abundance":0.208,"rank":15705,"name":"Cenpw","annotation":"Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] "},{"id":"ENSMUSP00000137614","abundance":0.208,"rank":15706,"name":"Polr3d","annotation":"DNA-directed RNA polymerase III subunit RPC4; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interfer [...] "},{"id":"ENSMUSP00000138455","abundance":0.207,"rank":15707,"name":"Lactbl1","annotation":"Lactamase, beta-like 1."},{"id":"ENSMUSP00000138351","abundance":0.207,"rank":15708,"name":"Sowahc","annotation":"Ankyrin repeat domain-containing protein SOWAHC; Belongs to the SOWAH family."},{"id":"ENSMUSP00000038264","abundance":0.207,"rank":15709,"name":"Obscn","annotation":"Obscurin; Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (By similarity). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1. Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate ( [...] "},{"id":"ENSMUSP00000045286","abundance":0.207,"rank":15710,"name":"Spag5","annotation":"Sperm-associated antigen 5; Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CD [...] "},{"id":"ENSMUSP00000100631","abundance":0.207,"rank":15711,"name":"Btbd35f17","annotation":"BTB domain-containing 35, family member 17."},{"id":"ENSMUSP00000136615","abundance":0.207,"rank":15712,"name":"Btbd35f5","annotation":"Germ cell-less protein-like 2; Possible function in spermatogenesis. Probable substrate- specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins."},{"id":"ENSMUSP00000137373","abundance":0.207,"rank":15713,"name":"Btbd35f20","annotation":"BTB domain-containing 35, family member 20."},{"id":"ENSMUSP00000136909","abundance":0.207,"rank":15714,"name":"Btbd35f24","annotation":"BTB domain-containing 35, family member 24."},{"id":"ENSMUSP00000136228","abundance":0.207,"rank":15715,"name":"Btbd35f10","annotation":"BTB domain-containing 35, family member 10."},{"id":"ENSMUSP00000158617","abundance":0.207,"rank":15716,"name":"Btbd35f26","annotation":"BTB domain-containing 35, family member 26."},{"id":"ENSMUSP00000158591","abundance":0.207,"rank":15717,"name":"Btbd35f9","annotation":"BTB domain containing 35, family member 9."},{"id":"ENSMUSP00000100637","abundance":0.207,"rank":15718,"name":"Btbd35f11","annotation":"BTB domain-containing 35, family member 11."},{"id":"ENSMUSP00000158683","abundance":0.207,"rank":15719,"name":"Btbd35f25","annotation":"BTB domain-containing 35, family member 25."},{"id":"ENSMUSP00000158776","abundance":0.207,"rank":15720,"name":"Btbd35f19","annotation":"BTB domain containing 35, family member 19."},{"id":"ENSMUSP00000136429","abundance":0.207,"rank":15721,"name":"Btbd35f2","annotation":"BTB domain-containing 35, family member 2."},{"id":"ENSMUSP00000141118","abundance":0.207,"rank":15722,"name":"Btbd35f16","annotation":"BTB domain-containing 35, family member 16."},{"id":"ENSMUSP00000060721","abundance":0.207,"rank":15723,"name":"Snip1","annotation":"Smad nuclear-interacting protein 1; Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA."},{"id":"ENSMUSP00000031069","abundance":0.206,"rank":15724,"name":"Sepsecs","annotation":"O-phosphoseryl-tRNA(Sec) selenium transferase; Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl- tRNA(Sec) required for selenoprotein biosynthesis. Belongs to the SepSecS family."},{"id":"ENSMUSP00000028982","abundance":0.206,"rank":15725,"name":"Sun5","annotation":"SUN domain-containing protein 5; Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope."},{"id":"ENSMUSP00000107230","abundance":0.206,"rank":15726,"name":"Rpgrip1","annotation":"X-linked retinitis pigmentosa GTPase regulator-interacting protein 1; May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells."},{"id":"ENSMUSP00000114175","abundance":0.206,"rank":15727,"name":"Mgat4a","annotation":"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells."},{"id":"ENSMUSP00000042716","abundance":0.206,"rank":15728,"name":"Nkx6-1","annotation":"Homeobox protein Nkx-6.1; Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Required for the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition. Involved in transcriptional regulation of the insulin gene. Together with NKX2-2 and IRX3, restricts the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals."},{"id":"ENSMUSP00000148943","abundance":0.206,"rank":15729,"name":"Olfr801","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000139765","abundance":0.206,"rank":15730,"name":"Gm29644","annotation":"Predicted gene 29644."},{"id":"ENSMUSP00000087098","abundance":0.206,"rank":15731,"name":"Mapk15","annotation":"Mitogen-activated protein kinase 15; Atypical MAPK protein that regulates several process such as autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent manner (By similarity). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 leading to autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation. Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling. Prevents t [...] "},{"id":"ENSMUSP00000035100","abundance":0.206,"rank":15732,"name":"Ttc21a","annotation":"Tetratricopeptide repeat protein 21A; Intraflagellar transport (IFT)-associated protein required for spermatogenesis. Required for sperm flagellar formation and intraflagellar transport. Belongs to the TTC21 family."},{"id":"ENSMUSP00000045443","abundance":0.205,"rank":15733,"name":"Zp3r","annotation":"Zona pellucida sperm-binding protein 3 receptor; Binds to ZP3 glycoprotein in egg zona pellucida. Probably involved in interactions between sperm acrosome and egg zona pellucida during and immediately following the acrosome reaction."},{"id":"ENSMUSP00000025025","abundance":0.205,"rank":15734,"name":"Dusp1","annotation":"Dual specificity protein phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily."},{"id":"ENSMUSP00000153531","abundance":0.205,"rank":15735,"name":"Arl11","annotation":"ADP-ribosylation factor-like protein 11; May play a role in apoptosis. May act as a tumor suppressor (By similarity)."},{"id":"ENSMUSP00000025897","abundance":0.205,"rank":15736,"name":"Map4k2","annotation":"Mitogen-activated protein kinase kinase kinase kinase 2; Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N- terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway (By similarity). Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine- polycytidine (poly(IC)), li [...] "},{"id":"ENSMUSP00000150078","abundance":0.205,"rank":15737,"name":"Olfr1191-ps1","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000015346","abundance":0.204,"rank":15738,"name":"Cnksr3","annotation":"Connector enhancer of kinase suppressor of ras 3; Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC- regulatory complex (ERC); Belongs to the CNKSR family."},{"id":"ENSMUSP00000026381","abundance":0.204,"rank":15739,"name":"Padi4","annotation":"Protein-arginine deiminase type-4; Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displaceme [...] "},{"id":"ENSMUSP00000077109","abundance":0.204,"rank":15740,"name":"Vmn2r2","annotation":"Vomeronasal 2, receptor 2."},{"id":"ENSMUSP00000022610","abundance":0.204,"rank":15741,"name":"Scara5","annotation":"Scavenger receptor class A member 5; Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non- transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the de [...] "},{"id":"ENSMUSP00000084454","abundance":0.204,"rank":15742,"name":"Fry","annotation":"Protein furry homolog; Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation. Belongs to the furry protein family."},{"id":"ENSMUSP00000092613","abundance":0.204,"rank":15743,"name":"Gm7347","annotation":"Predicted gene 7347."},{"id":"ENSMUSP00000135184","abundance":0.204,"rank":15744,"name":"Cdhr4","annotation":"Cadherin-related family member 4."},{"id":"ENSMUSP00000072982","abundance":0.204,"rank":15745,"name":"Ccdc177","annotation":"Coiled-coil domain-containing protein 177."},{"id":"ENSMUSP00000093485","abundance":0.203,"rank":15746,"name":"Map3k5","annotation":"Mitogen-activated protein kinase kinase kinase 5; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Me [...] "},{"id":"ENSMUSP00000039261","abundance":0.203,"rank":15747,"name":"Fam189b","annotation":"Protein FAM189B; Belongs to the FAM189 family."},{"id":"ENSMUSP00000072632","abundance":0.203,"rank":15748,"name":"Olfr340","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000068560","abundance":0.202,"rank":15749,"name":"Adnp2","annotation":"Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000092440","abundance":0.202,"rank":15750,"name":"Cfap65","annotation":"Cilia- and flagella-associated protein 65; May play a role in sperm motility. Belongs to the CFAP65 family."},{"id":"ENSMUSP00000126165","abundance":0.202,"rank":15751,"name":"Vmn2r3","annotation":"Vomeronasal 2, receptor 3."},{"id":"ENSMUSP00000073402","abundance":0.202,"rank":15752,"name":"Phf1","annotation":"PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing [...] "},{"id":"ENSMUSP00000004120","abundance":0.202,"rank":15753,"name":"Fancl","annotation":"E3 ubiquitin-protein ligase FANCL; Ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCI. May stimulate the ubiquitin release from UBE2W. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth."},{"id":"ENSMUSP00000091331","abundance":0.202,"rank":15754,"name":"Arhgef40","annotation":"Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF)."},{"id":"ENSMUSP00000034592","abundance":0.202,"rank":15755,"name":"Dscaml1","annotation":"Down syndrome cell adhesion molecule-like protein 1 homolog; Cell adhesion molecule that plays a role in neuronal self- avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Promotes both isoneuronal self-avoidance for creating an orderly neurite arborization in retinal rod bipolar cells and heteroneuronal self-avoidance to maintain mosaic spacing between AII amacrine cells. Adhesion molecule that promotes lamina-specific synaptic connections in the retina: expressed in specific subsets of interneurons and retinal gangli [...] "},{"id":"ENSMUSP00000024954","abundance":0.202,"rank":15756,"name":"Epas1","annotation":"Endothelial PAS domain-containing protein 1; Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activ [...] "},{"id":"ENSMUSP00000139591","abundance":0.202,"rank":15757,"name":"Zfy2","annotation":"Zinc finger Y-chromosomal protein 2; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity)."},{"id":"ENSMUSP00000153894","abundance":0.202,"rank":15758,"name":"Vmn1r87","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000104675","abundance":0.202,"rank":15759,"name":"Zfp968","annotation":"Zinc finger protein 968."},{"id":"ENSMUSP00000104577","abundance":0.202,"rank":15760,"name":"Zfp966","annotation":"Zinc finger protein 966."},{"id":"ENSMUSP00000136521","abundance":0.202,"rank":15761,"name":"Zfp967","annotation":"Zinc finger protein 967."},{"id":"ENSMUSP00000136479","abundance":0.202,"rank":15762,"name":"Zfp969","annotation":"Zinc finger protein 969."},{"id":"ENSMUSP00000100636","abundance":0.202,"rank":15763,"name":"Btbd35f18","annotation":"BTB domain-containing 35, family member 18."},{"id":"ENSMUSP00000034359","abundance":0.201,"rank":15764,"name":"Tradd","annotation":"Tumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (By similarity). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A."},{"id":"ENSMUSP00000076666","abundance":0.201,"rank":15765,"name":"Dapk1","annotation":"Death-associated protein kinase 1; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress [...] "},{"id":"ENSMUSP00000138418","abundance":0.201,"rank":15766,"name":"Cul9","annotation":"Cullin-9; Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5. Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function; Belongs to the cullin family."},{"id":"ENSMUSP00000029271","abundance":0.2,"rank":15767,"name":"Trpc3","annotation":"Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3 (By similarity). May also be activated by internal calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC [...] "},{"id":"ENSMUSP00000059598","abundance":0.2,"rank":15768,"name":"Pcdhb15","annotation":"Protocadherin beta 15."},{"id":"ENSMUSP00000015239","abundance":0.2,"rank":15769,"name":"Fbxw5","annotation":"F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin- protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degrad [...] "},{"id":"ENSMUSP00000109737","abundance":0.2,"rank":15770,"name":"Entr1","annotation":"Endosome-associated-trafficking regulator 1; May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface. Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (By similarity)."},{"id":"ENSMUSP00000096975","abundance":0.2,"rank":15771,"name":"Wbp1l","annotation":"WW domain binding protein 1-like."},{"id":"ENSMUSP00000065744","abundance":0.2,"rank":15772,"name":"D430042O09Rik","annotation":"Protein KIAA0556; May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex."},{"id":"ENSMUSP00000056958","abundance":0.2,"rank":15773,"name":"Vwce","annotation":"Von Willebrand factor C and EGF domain-containing protein; May be a regulatory element in the beta-catenin signaling pathway and a target for chemoprevention of hapatocellular carcinoma."},{"id":"ENSMUSP00000031198","abundance":0.199,"rank":15774,"name":"Dipk1a","annotation":"Divergent protein kinase domain 1A."},{"id":"ENSMUSP00000036482","abundance":0.199,"rank":15775,"name":"Ice1","annotation":"Little elongation complex subunit 1; Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (By similarity). Belongs to the ICE1 family."},{"id":"ENSMUSP00000052126","abundance":0.199,"rank":15776,"name":"Ssc5d","annotation":"Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D; Binds to extracellular matrix proteins. Binds to pathogen- associated molecular patterns (PAMPs) present on the cell walls of Gram-positive and Gram-negative bacteria and fungi, behaving as a pattern recognition receptor (PRR). Induces bacterial and fungal aggregation and subsequent inhibition of PAMP-induced cytokine release. Does not possess intrinsic bactericidal activity. May play a role in the innate defense and homeostasis of certain epithelial surfaces."},{"id":"ENSMUSP00000025571","abundance":0.199,"rank":15777,"name":"Cd5","annotation":"T-cell surface glycoprotein CD5; May act as a receptor in regulating T-cell proliferation."},{"id":"ENSMUSP00000137019","abundance":0.199,"rank":15778,"name":"Gm19965","annotation":"Predicted gene, 19965."},{"id":"ENSMUSP00000040585","abundance":0.199,"rank":15779,"name":"Tbc1d19","annotation":"TBC1 domain family, member 19."},{"id":"ENSMUSP00000140013","abundance":0.199,"rank":15780,"name":"Btbd35f23","annotation":"BTB domain-containing 35, family member 23."},{"id":"ENSMUSP00000022459","abundance":0.198,"rank":15781,"name":"Phf7","annotation":"PHD finger protein 7; May play a role in spermatogenesis."},{"id":"ENSMUSP00000112592","abundance":0.198,"rank":15782,"name":"Lmtk3","annotation":"Serine/threonine-protein kinase LMTK3; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons."},{"id":"ENSMUSP00000002053","abundance":0.198,"rank":15783,"name":"Npas1","annotation":"Neuronal PAS domain-containing protein 1; May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH."},{"id":"ENSMUSP00000116426","abundance":0.198,"rank":15784,"name":"Rapgef3","annotation":"Rap guanine nucleotide exchange factor 3; Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP- induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junction [...] "},{"id":"ENSMUSP00000039704","abundance":0.198,"rank":15785,"name":"Parp12","annotation":"Protein mono-ADP-ribosyltransferase PARP12; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins."},{"id":"ENSMUSP00000121926","abundance":0.198,"rank":15786,"name":"4933403O08Rik","annotation":"RIKEN cDNA 4933403O08 gene."},{"id":"ENSMUSP00000144038","abundance":0.198,"rank":15787,"name":"Zfp811","annotation":"Zinc finger protein 811."},{"id":"ENSMUSP00000114068","abundance":0.198,"rank":15788,"name":"Zan","annotation":"Zonadhesin; Binds in a species-specific manner to the zona pellucida of the egg. May be involved in gamete recognition and/or signaling."},{"id":"ENSMUSP00000103069","abundance":0.197,"rank":15789,"name":"Krt39","annotation":"Keratin, type I cytoskeletal 39; May play a role in late hair differentiation."},{"id":"ENSMUSP00000158071","abundance":0.197,"rank":15790,"name":"Slc4a9","annotation":"Anion exchange protein."},{"id":"ENSMUSP00000092811","abundance":0.197,"rank":15791,"name":"Camkmt","annotation":"Calmodulin-lysine N-methyltransferase; Catalyzes the trimethylation of 'Lys-116' in calmodulin."},{"id":"ENSMUSP00000097101","abundance":0.197,"rank":15792,"name":"Brwd1","annotation":"Bromodomain and WD repeat-containing protein 1; May be a transcriptional activator. May be involved in chromatin remodeling. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape."},{"id":"ENSMUSP00000092401","abundance":0.197,"rank":15793,"name":"Pnmal2","annotation":"PNMA-like 2."},{"id":"ENSMUSP00000043108","abundance":0.197,"rank":15794,"name":"Brip1","annotation":"Fanconi anemia group J protein homolog; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1 (By similarity)."},{"id":"ENSMUSP00000039518","abundance":0.196,"rank":15795,"name":"Ckap2","annotation":"Cytoskeleton-associated protein 2; Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53-dependent manner; Belongs to the CKAP2 family."},{"id":"ENSMUSP00000044350","abundance":0.196,"rank":15796,"name":"Azi2","annotation":"5-azacytidine-induced protein 2; Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1."},{"id":"ENSMUSP00000020350","abundance":0.196,"rank":15797,"name":"Lgr5","annotation":"Leucine-rich repeat-containing G-protein coupled receptor 5; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the  [...] "},{"id":"ENSMUSP00000141169","abundance":0.196,"rank":15798,"name":"Carf","annotation":"Calcium-responsive transcription factor; Acts as a transcriptional activator that mediates the calcium- and neuron-selective induction of BDNF exon III transcription. Binds to the consensus calcium-response element CaRE1 5'-CTATTTCGAG-3' sequence (By similarity)."},{"id":"ENSMUSP00000023818","abundance":0.196,"rank":15799,"name":"Calcoco1","annotation":"Calcium-binding and coiled-coil domain-containing protein 1; Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N- terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER- activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional act [...] "},{"id":"ENSMUSP00000079546","abundance":0.196,"rank":15800,"name":"Chsy3","annotation":"Chondroitin sulfate synthase 3; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer. Specific activity is much reduced compared to CHSY1."},{"id":"ENSMUSP00000009689","abundance":0.196,"rank":15801,"name":"Kcnq1","annotation":"Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] "},{"id":"ENSMUSP00000103650","abundance":0.196,"rank":15802,"name":"Zfp619","annotation":"Zinc finger protein 619."},{"id":"ENSMUSP00000056315","abundance":0.195,"rank":15803,"name":"Hoxb13","annotation":"Homeobox protein Hox-B13; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (By similarity). Belongs to the Abd-B homeobox family."},{"id":"ENSMUSP00000049003","abundance":0.195,"rank":15804,"name":"Greb1l","annotation":"GREB1-like protein; Plays a major role in early metanephros and genital development; Belongs to the GREB1 family."},{"id":"ENSMUSP00000054126","abundance":0.195,"rank":15805,"name":"Ikbke","annotation":"Inhibitor of nuclear factor kappa-B kinase subunit epsilon; Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I- like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the  [...] "},{"id":"ENSMUSP00000078984","abundance":0.195,"rank":15806,"name":"4930595M18Rik","annotation":"RIKEN cDNA 4930595M18 gene."},{"id":"ENSMUSP00000062662","abundance":0.195,"rank":15807,"name":"Gfod1","annotation":"Glucose-fructose oxidoreductase domain-containing protein 1."},{"id":"ENSMUSP00000023504","abundance":0.195,"rank":15808,"name":"Nr1i2","annotation":"Nuclear receptor subfamily 1 group I member 2; Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and pro [...] "},{"id":"ENSMUSP00000015333","abundance":0.195,"rank":15809,"name":"Casd1","annotation":"N-acetylneuraminate 9-O-acetyltransferase; O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids. Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition. Belongs to the PC-esterase family. CASD1 subfamily."},{"id":"ENSMUSP00000115325","abundance":0.195,"rank":15810,"name":"Fzd3","annotation":"Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] "},{"id":"ENSMUSP00000064809","abundance":0.195,"rank":15811,"name":"Slc22a26","annotation":"Solute carrier family 22 (organic cation transporter), member 26."},{"id":"ENSMUSP00000058110","abundance":0.194,"rank":15812,"name":"Vwde","annotation":"Von Willebrand factor D and EGF domain-containing protein."},{"id":"ENSMUSP00000158732","abundance":0.194,"rank":15813,"name":"Btbd35f22","annotation":"Uncharacterized protein."},{"id":"ENSMUSP00000100632","abundance":0.194,"rank":15814,"name":"Btbd35f28","annotation":"BTB domain-containing 35, family member 28."},{"id":"ENSMUSP00000100634","abundance":0.194,"rank":15815,"name":"Btbd35f21","annotation":"BTB domain-containing 35, family member 21."},{"id":"ENSMUSP00000137428","abundance":0.194,"rank":15816,"name":"Btbd35f29","annotation":"BTB domain-containing 35, family member 29."},{"id":"ENSMUSP00000158815","abundance":0.194,"rank":15817,"name":"Btbd35f30","annotation":"BTB domain containing 35, family member 30."},{"id":"ENSMUSP00000101364","abundance":0.194,"rank":15818,"name":"Zfp980","annotation":"Zinc finger protein 980."},{"id":"ENSMUSP00000001002","abundance":0.194,"rank":15819,"name":"Heatr6","annotation":"HEAT repeat-containing protein 6."},{"id":"ENSMUSP00000149916","abundance":0.194,"rank":15820,"name":"Olfr346","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000068203","abundance":0.194,"rank":15821,"name":"Dcbld1","annotation":"Discoidin, CUB and LCCL domain-containing protein 1."},{"id":"ENSMUSP00000090882","abundance":0.194,"rank":15822,"name":"Spdl1","annotation":"Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. Acts as an adapter protein linking the dynein motor complex to various [...] "},{"id":"ENSMUSP00000102707","abundance":0.194,"rank":15823,"name":"Ankrd34a","annotation":"Ankyrin repeat domain 34A."},{"id":"ENSMUSP00000032802","abundance":0.193,"rank":15824,"name":"Zfp84","annotation":"Zinc finger protein 84."},{"id":"ENSMUSP00000068804","abundance":0.193,"rank":15825,"name":"Cspp1","annotation":"Centrosome and spindle pole associated protein 1; May play a role in cell-cycle-dependent microtubule organization."},{"id":"ENSMUSP00000027121","abundance":0.193,"rank":15826,"name":"Rftn2","annotation":"Raftlin-2; Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling."},{"id":"ENSMUSP00000042162","abundance":0.193,"rank":15827,"name":"Dph1","annotation":"2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). Acts also as a tumor suppressor in lung and breast cancers. Plays a role in embryonic growth, organogenesis and postnatal survival. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells (By similarity)."},{"id":"ENSMUSP00000104977","abundance":0.192,"rank":15828,"name":"Tubgcp6","annotation":"Gamma-tubulin complex component 6; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family."},{"id":"ENSMUSP00000093626","abundance":0.192,"rank":15829,"name":"Krtap26-1","annotation":"Keratin-associated protein 26-1; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity); Belongs to the PMG family."},{"id":"ENSMUSP00000047387","abundance":0.192,"rank":15830,"name":"Dock4","annotation":"Dedicator of cytokinesis protein 4; Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP (By similarity)."},{"id":"ENSMUSP00000020113","abundance":0.192,"rank":15831,"name":"Poc1b","annotation":"POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity."},{"id":"ENSMUSP00000091805","abundance":0.191,"rank":15832,"name":"Fam217b","annotation":"Family with sequence similarity 217, member B."},{"id":"ENSMUSP00000151387","abundance":0.191,"rank":15833,"name":"Adamts4","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|- Ala-393' site (By similarity)."},{"id":"ENSMUSP00000095102","abundance":0.191,"rank":15834,"name":"9930111J21Rik1","annotation":"RIKEN cDNA 9930111J21 gene 1."},{"id":"ENSMUSP00000121755","abundance":0.191,"rank":15835,"name":"Aknad1","annotation":"AKNA domain-containing 1."},{"id":"ENSMUSP00000092355","abundance":0.191,"rank":15836,"name":"Relb","annotation":"Transcription factor RelB; NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishab [...] "},{"id":"ENSMUSP00000028728","abundance":0.191,"rank":15837,"name":"Ubr1","annotation":"E3 ubiquitin-protein ligase UBR1; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth (By similarity)."},{"id":"ENSMUSP00000039691","abundance":0.191,"rank":15838,"name":"Drd5","annotation":"D(1B) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000123886","abundance":0.191,"rank":15839,"name":"Esp1","annotation":"Exocrine gland-secreted peptide 1; Male-specific phermone which is recognized by the Vmn2r116/V2rp5 receptor in the vomeronasal organ (VNO) and enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. Belongs to the exocrine gland-secreted peptide family."},{"id":"ENSMUSP00000147104","abundance":0.191,"rank":15840,"name":"Muc16","annotation":"Mucin 16."},{"id":"ENSMUSP00000117303","abundance":0.191,"rank":15841,"name":"Btbd35f3","annotation":"BTB domain containing 35, family member 3."},{"id":"ENSMUSP00000100628","abundance":0.191,"rank":15842,"name":"Btbd35f4","annotation":"BTB domain-containing 35, family member 3."},{"id":"ENSMUSP00000110668","abundance":0.19,"rank":15843,"name":"Agbl3","annotation":"Cytosolic carboxypeptidase 3; Metallocarboxypeptidase that mediates both deglutamylation and deaspartylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene- encoded polyglutamates or polyaspartates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin."},{"id":"ENSMUSP00000081864","abundance":0.19,"rank":15844,"name":"Dnah17","annotation":"Dynein heavy chain 17, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity)."},{"id":"ENSMUSP00000108340","abundance":0.19,"rank":15845,"name":"Apex2","annotation":"DNA-(apurinic or apyrimidinic site) lyase 2; Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'- phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heterodup [...] "},{"id":"ENSMUSP00000078587","abundance":0.19,"rank":15846,"name":"Zfp119a","annotation":"KRAB zinc finger protein."},{"id":"ENSMUSP00000099826","abundance":0.189,"rank":15847,"name":"Col23a1","annotation":"Collagen alpha-1(XXIII) chain."},{"id":"ENSMUSP00000117414","abundance":0.189,"rank":15848,"name":"Tbc1d14","annotation":"TBC1 domain family member 14; Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy."},{"id":"ENSMUSP00000031845","abundance":0.189,"rank":15849,"name":"Gsdme","annotation":"Gasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53."},{"id":"ENSMUSP00000108921","abundance":0.189,"rank":15850,"name":"Frs3","annotation":"Fibroblast growth factor receptor substrate 3; Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2."},{"id":"ENSMUSP00000096316","abundance":0.189,"rank":15851,"name":"Gm10665","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000096340","abundance":0.189,"rank":15852,"name":"Gm10670","annotation":"Predicted gene 10670."},{"id":"ENSMUSP00000097904","abundance":0.189,"rank":15853,"name":"Tanc2","annotation":"Protein TANC2; Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines; Belongs to the TANC family."},{"id":"ENSMUSP00000023561","abundance":0.189,"rank":15854,"name":"Senp2","annotation":"Sentrin-specific protease 2; Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate th [...] "},{"id":"ENSMUSP00000102443","abundance":0.188,"rank":15855,"name":"Dab1","annotation":"Disabled homolog 1; Adapter molecule functioning in neural development. May regulate SIAH1 activity."},{"id":"ENSMUSP00000077574","abundance":0.188,"rank":15856,"name":"Dchs1","annotation":"Protocadherin-16; Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation."},{"id":"ENSMUSP00000032071","abundance":0.187,"rank":15857,"name":"Dusp11","annotation":"RNA/RNP complex-1-interacting phosphatase; Possesses RNA 5'-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism."},{"id":"ENSMUSP00000122424","abundance":0.187,"rank":15858,"name":"Ifi203","annotation":"Interferon-activable protein 203."},{"id":"ENSMUSP00000108653","abundance":0.186,"rank":15859,"name":"Radx","annotation":"RPA-related protein RADX; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability. Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks."},{"id":"ENSMUSP00000069728","abundance":0.186,"rank":15860,"name":"Gsx1","annotation":"GS homeobox 1; Probable transcription factor that binds to the DNA sequence 5'-GC[TA][AC]ATTA[GA]-3'. Activates the transcription of the GHRH gene. Plays an important role in pituitary development. Belongs to the Antp homeobox family."},{"id":"ENSMUSP00000130746","abundance":0.186,"rank":15861,"name":"Slco1a4","annotation":"Solute carrier organic anion transporter family member 1A4; Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone- 3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones; Belongs to the organo anion transporter (TC 2.A.60) family."},{"id":"ENSMUSP00000122000","abundance":0.186,"rank":15862,"name":"Bcorl1","annotation":"BCL-6 corepressor-like protein 1; Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA- binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor (By similarity)."},{"id":"ENSMUSP00000103407","abundance":0.186,"rank":15863,"name":"Zbbx","annotation":"Zinc finger B-box domain-containing protein 1."},{"id":"ENSMUSP00000042007","abundance":0.186,"rank":15864,"name":"Fstl4","annotation":"Follistatin-related protein 4."},{"id":"ENSMUSP00000077644","abundance":0.186,"rank":15865,"name":"Slc9b1","annotation":"Sodium/hydrogen exchanger 9B1; Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility."},{"id":"ENSMUSP00000001059","abundance":0.186,"rank":15866,"name":"Ern1","annotation":"Serine/threonine-protein kinase/endoribonuclease IRE1; Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endor [...] "},{"id":"ENSMUSP00000029429","abundance":0.185,"rank":15867,"name":"Wnt2b","annotation":"Protein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development."},{"id":"ENSMUSP00000098893","abundance":0.185,"rank":15868,"name":"Nhsl2","annotation":"NHS-like protein 2; Belongs to the NHS family."},{"id":"ENSMUSP00000040217","abundance":0.185,"rank":15869,"name":"Zc3h12d","annotation":"Probable ribonuclease ZC3H12D; May regulate cell growth likely by suppressing RB1 phosphorylation (By similarity). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages. Serve as a tumor suppressor in certain leukemia cells (By similarity). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (By similarity)."},{"id":"ENSMUSP00000104580","abundance":0.185,"rank":15870,"name":"Zfp970","annotation":"OTTMUSG00000016588 protein."},{"id":"ENSMUSP00000004655","abundance":0.185,"rank":15871,"name":"Psg17","annotation":"Pregnancy-specific glycoprotein 17."},{"id":"ENSMUSP00000031719","abundance":0.185,"rank":15872,"name":"Fscn3","annotation":"Fascin-3; Acts as an actin bundling protein."},{"id":"ENSMUSP00000115873","abundance":0.185,"rank":15873,"name":"Rufy4","annotation":"RUN and FYVE domain-containing protein 4; Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE- type zinc finger."},{"id":"ENSMUSP00000019044","abundance":0.185,"rank":15874,"name":"Slc22a5","annotation":"Solute carrier family 22 member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3."},{"id":"ENSMUSP00000055697","abundance":0.185,"rank":15875,"name":"P2ry6","annotation":"P2Y purinoceptor 6; Receptor for extracellular UTP > ADP = 2-methylthio-ATP > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Functionally coupled to phospholipase C (By similarity)."},{"id":"ENSMUSP00000046204","abundance":0.184,"rank":15876,"name":"Hydin","annotation":"Hydrocephalus-inducing protein; Required for ciliary motility."},{"id":"ENSMUSP00000124111","abundance":0.184,"rank":15877,"name":"Pitpnm2","annotation":"Membrane-associated phosphatidylinositol transfer protein 2; Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions (By similarity)."},{"id":"ENSMUSP00000065200","abundance":0.184,"rank":15878,"name":"Mepe","annotation":"Matrix extracellular phosphoglycoprotein; Regulates renal phosphate and uric acid excretion. Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage. Increases dental pulp stem cell proliferation (By similarity). Belongs to the PF07175/osteoregulin family."},{"id":"ENSMUSP00000023044","abundance":0.184,"rank":15879,"name":"Fam83f","annotation":"Protein FAM83F; Belongs to the FAM83 family."},{"id":"ENSMUSP00000047831","abundance":0.184,"rank":15880,"name":"Trmt12","annotation":"tRNA wybutosine-synthesizing protein 2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity)."},{"id":"ENSMUSP00000126879","abundance":0.184,"rank":15881,"name":"Zfp600","annotation":"Zinc finger protein 600."},{"id":"ENSMUSP00000156109","abundance":0.184,"rank":15882,"name":"Senp5","annotation":"Sentrin-specific protease 5; Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division."},{"id":"ENSMUSP00000067556","abundance":0.184,"rank":15883,"name":"Fat2","annotation":"Protocadherin Fat 2; Involved in the regulation of cell migration (By similarity). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity)."},{"id":"ENSMUSP00000083386","abundance":0.184,"rank":15884,"name":"Vmn2r54","annotation":"Vomeronasal 2, receptor 54."},{"id":"ENSMUSP00000035260","abundance":0.184,"rank":15885,"name":"Pomt2","annotation":"Protein O-mannosyl-transferase 2; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins."},{"id":"ENSMUSP00000020948","abundance":0.184,"rank":15886,"name":"Abca8b","annotation":"ATP-binding cassette sub-family A member 8-B; ATP-dependent lipophilic drug transporter; Belongs to the ABC transporter superfamily. ABCA family."},{"id":"ENSMUSP00000120133","abundance":0.183,"rank":15887,"name":"AI661453","annotation":"Uncharacterized protein C6orf132 homolog."},{"id":"ENSMUSP00000123432","abundance":0.183,"rank":15888,"name":"Fam129c","annotation":"Family with sequence similarity 129, member C."},{"id":"ENSMUSP00000091093","abundance":0.183,"rank":15889,"name":"Tbc1d9","annotation":"TBC1 domain family member 9; May act as a GTPase-activating protein for Rab family protein(s)."},{"id":"ENSMUSP00000127797","abundance":0.183,"rank":15890,"name":"Shq1","annotation":"Protein SHQ1 homolog; Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. Belongs to the SHQ1 family."},{"id":"ENSMUSP00000012873","abundance":0.183,"rank":15891,"name":"Zfp729b","annotation":"Zinc finger protein 729b."},{"id":"ENSMUSP00000044268","abundance":0.183,"rank":15892,"name":"Med13","annotation":"Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)."},{"id":"ENSMUSP00000021359","abundance":0.182,"rank":15893,"name":"Pole2","annotation":"DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity)."},{"id":"ENSMUSP00000142227","abundance":0.182,"rank":15894,"name":"Pcdhgb4","annotation":"Protocadherin gamma subfamily B, 4."},{"id":"ENSMUSP00000001126","abundance":0.182,"rank":15895,"name":"Slc46a1","annotation":"Proton-coupled folate transporter; Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme."},{"id":"ENSMUSP00000030614","abundance":0.182,"rank":15896,"name":"CK137956","annotation":"cDNA sequence CK137956."},{"id":"ENSMUSP00000152331","abundance":0.182,"rank":15897,"name":"Ippk","annotation":"Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis."},{"id":"ENSMUSP00000035773","abundance":0.182,"rank":15898,"name":"Ttc22","annotation":"Tetratricopeptide repeat protein 22."},{"id":"ENSMUSP00000037126","abundance":0.182,"rank":15899,"name":"Bub1b","annotation":"Mitotic checkpoint serine/threonine-protein kinase BUB1 beta; Essential component of the mitotic checkpoint. Required for normal mitosis progression and tumor suppression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore local [...] "},{"id":"ENSMUSP00000158750","abundance":0.181,"rank":15900,"name":"Gm10130","annotation":"Predicted gene 10130."},{"id":"ENSMUSP00000043596","abundance":0.181,"rank":15901,"name":"Cdhr2","annotation":"Cadherin-related family member 2; Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells."},{"id":"ENSMUSP00000116191","abundance":0.181,"rank":15902,"name":"Stxbp4","annotation":"Syntaxin-binding protein 4; Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose."},{"id":"ENSMUSP00000070270","abundance":0.181,"rank":15903,"name":"Col8a2","annotation":"Collagen alpha-2(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity)."},{"id":"ENSMUSP00000024905","abundance":0.18,"rank":15904,"name":"Ralbp1","annotation":"RalA-binding protein 1; Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4- dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off [...] "},{"id":"ENSMUSP00000043780","abundance":0.18,"rank":15905,"name":"Rfwd3","annotation":"E3 ubiquitin-protein ligase RFWD3; E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage. Plays a key role in RPA-mediated DNA damage signaling and repair. Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination. Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA  [...] "},{"id":"ENSMUSP00000029252","abundance":0.18,"rank":15906,"name":"Lrrc34","annotation":"Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro."},{"id":"ENSMUSP00000036227","abundance":0.179,"rank":15907,"name":"St6galnac5","annotation":"Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Involved in the biosynthesis of ganglioside GD1a from GM1b. It exhibits higher activity with glycolipids than with glycoproteins. Belongs to the glycosyltransferase 29 family."},{"id":"ENSMUSP00000127506","abundance":0.179,"rank":15908,"name":"Vmn2r18","annotation":"Vomeronasal 2, receptor 18."},{"id":"ENSMUSP00000093120","abundance":0.179,"rank":15909,"name":"Mucl3","annotation":"Mucin-like protein 3; May modulate NF-kappaB signaling and play a role in cell growth."},{"id":"ENSMUSP00000041897","abundance":0.179,"rank":15910,"name":"Syde2","annotation":"Synapse defective 1, Rho GTPase, homolog 2 (C. elegans)."},{"id":"ENSMUSP00000067334","abundance":0.179,"rank":15911,"name":"Zfp217","annotation":"Zinc finger protein 217."},{"id":"ENSMUSP00000116056","abundance":0.179,"rank":15912,"name":"Tril","annotation":"TLR4 interactor with leucine rich repeats; Component of the TLR4 signaling complex. Mediates the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion (By similarity)."},{"id":"ENSMUSP00000055482","abundance":0.178,"rank":15913,"name":"Dnajc22","annotation":"DnaJ homolog subfamily C member 22; May function as a co-chaperone."},{"id":"ENSMUSP00000032497","abundance":0.178,"rank":15914,"name":"D6Wsu163e","annotation":"Protein C12orf4 homolog; Plays a role in mast cell degranulation."},{"id":"ENSMUSP00000097219","abundance":0.178,"rank":15915,"name":"Ano3","annotation":"Anoctamin-3; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Does not exhibit calcium-activated chloride channel (CaCC) activity. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity."},{"id":"ENSMUSP00000025702","abundance":0.178,"rank":15916,"name":"Snx15","annotation":"Sorting nexin-15; May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN (By similarity); Belongs to the sorting nexin family."},{"id":"ENSMUSP00000129772","abundance":0.178,"rank":15917,"name":"Dis3l","annotation":"DIS3-like exonuclease 1; Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA."},{"id":"ENSMUSP00000158621","abundance":0.178,"rank":15918,"name":"Zfp469","annotation":"Zinc finger protein 469."},{"id":"ENSMUSP00000064516","abundance":0.178,"rank":15919,"name":"Lancl3","annotation":"LanC-like protein 3."},{"id":"ENSMUSP00000103606","abundance":0.178,"rank":15920,"name":"Zfp658","annotation":"Zinc finger protein 658."},{"id":"ENSMUSP00000103500","abundance":0.177,"rank":15921,"name":"Tom1l1","annotation":"TOM1-like protein 1; Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions. Belongs to the TOM1 family."},{"id":"ENSMUSP00000017126","abundance":0.177,"rank":15922,"name":"Pom121l2","annotation":"POM121-like protein 2; Belongs to the POM121 family."},{"id":"ENSMUSP00000037406","abundance":0.177,"rank":15923,"name":"Ttll4","annotation":"Tubulin polyglutamylase TTLL4; Glutamylase which preferentially modifies beta-tubulin and non-tubulin proteins, such as NAP1L1, NAP1L4 and CGAS. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Involved in formation of short side-chains. Mediates initiation of polyglutamylation of nucleosome assembly proteins NAP1L1 and NAP1L4. Also acts as a monoglutamylase: generates monoglutamylation of CGAS, leading to impair the nucleotidyltransferase activity of CGAS."},{"id":"ENSMUSP00000040546","abundance":0.177,"rank":15924,"name":"D630003M21Rik","annotation":"Uncharacterized protein KIAA1755 homolog."},{"id":"ENSMUSP00000052484","abundance":0.177,"rank":15925,"name":"Tmem132e","annotation":"Transmembrane protein 132E; Required for normal inner ear hair cell function and hearing."},{"id":"ENSMUSP00000005630","abundance":0.176,"rank":15926,"name":"Msh4","annotation":"MutS protein homolog 4; Involved in meiotic recombination. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis."},{"id":"ENSMUSP00000093813","abundance":0.176,"rank":15927,"name":"Muc4","annotation":"Mucin-4."},{"id":"ENSMUSP00000108506","abundance":0.176,"rank":15928,"name":"Dzip1l","annotation":"Zinc finger protein DZIP1L; Involved in primary cilium formation. Probably acts as a transition zone protein required for localization of PKD1/PC1 and PKD2/PC2 to the ciliary membrane (By similarity). Belongs to the DZIP C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000105769","abundance":0.176,"rank":15929,"name":"Gpcpd1","annotation":"Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity."},{"id":"ENSMUSP00000047308","abundance":0.176,"rank":15930,"name":"Phf2","annotation":"Lysine-specific demethylase PHF2; Lysine demethylase that demethylates both histones and non- histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethy [...] "},{"id":"ENSMUSP00000024880","abundance":0.176,"rank":15931,"name":"Vit","annotation":"Vitrin; Promotes matrix assembly and cell adhesiveness. Plays a role in spinal cord formation by regulating the proliferation and differentiation of neural stem cells."},{"id":"ENSMUSP00000098320","abundance":0.176,"rank":15932,"name":"Adam1a","annotation":"Disintegrin and metalloproteinase domain-containing protein 1a; May be involved in sperm-egg fusion."},{"id":"ENSMUSP00000091845","abundance":0.176,"rank":15933,"name":"Ctcfl","annotation":"Transcriptional repressor CTCFL; Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases a [...] "},{"id":"ENSMUSP00000116575","abundance":0.176,"rank":15934,"name":"Elp4","annotation":"Elongator complex protein 4; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the ELP4 family."},{"id":"ENSMUSP00000026448","abundance":0.176,"rank":15935,"name":"Faap100","annotation":"Fanconi anemia core complex-associated protein 100; Plays a role in Fanconi anemia-associated DNA damage response network. Regulates FANCD2 monoubiquitination and the stability of the FA core complex. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed (By similarity)."},{"id":"ENSMUSP00000019386","abundance":0.176,"rank":15936,"name":"Ripk4","annotation":"Receptor-interacting serine/threonine-protein kinase 4; Involved in stratified epithelial development (By similarity). It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation."},{"id":"ENSMUSP00000080128","abundance":0.176,"rank":15937,"name":"Nphp4","annotation":"Nephrocystin-4; Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (By similarity). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expr [...] "},{"id":"ENSMUSP00000148686","abundance":0.175,"rank":15938,"name":"Mast3","annotation":"Microtubule-associated serine/threonine-protein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family."},{"id":"ENSMUSP00000105413","abundance":0.175,"rank":15939,"name":"Asxl1","annotation":"Polycomb group protein ASXL1; Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity). Acts as a sensor of N(6 [...] "},{"id":"ENSMUSP00000028928","abundance":0.175,"rank":15940,"name":"Gzf1","annotation":"GDNF-inducible zinc finger protein 1; Transcriptional repressor that binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3'). May be regulating VSX2/HOX10 expression."},{"id":"ENSMUSP00000124972","abundance":0.175,"rank":15941,"name":"Ccdc85a","annotation":"Coiled-coil domain-containing protein 85A; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family; Belongs to the CCDC85 family."},{"id":"ENSMUSP00000112847","abundance":0.175,"rank":15942,"name":"Plagl1","annotation":"Pleiomorphic adenoma gene-like 1."},{"id":"ENSMUSP00000027639","abundance":0.174,"rank":15943,"name":"Marco","annotation":"Macrophage receptor MARCO; Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (By similarity)."},{"id":"ENSMUSP00000040025","abundance":0.174,"rank":15944,"name":"Herc3","annotation":"Hect domain and RLD 3."},{"id":"ENSMUSP00000108876","abundance":0.174,"rank":15945,"name":"Impg1","annotation":"Interphotoreceptor matrix proteoglycan 1; May interact with hyaluronan which may serve to form a basic macromolecular scaffold comprising the insoluble interphotoreceptor matrix."},{"id":"ENSMUSP00000067316","abundance":0.174,"rank":15946,"name":"A430033K04Rik","annotation":"RIKEN cDNA A430033K04 gene."},{"id":"ENSMUSP00000085569","abundance":0.174,"rank":15947,"name":"Gm10220","annotation":"Predicted gene 10220."},{"id":"ENSMUSP00000069697","abundance":0.174,"rank":15948,"name":"5031410I06Rik","annotation":"RIKEN cDNA 5031410I06 gene."},{"id":"ENSMUSP00000108603","abundance":0.174,"rank":15949,"name":"Catsperd","annotation":"Cation channel sperm-associated protein subunit delta; Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane."},{"id":"ENSMUSP00000051869","abundance":0.174,"rank":15950,"name":"Pmel","annotation":"Melanocyte protein PMEL; Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures (By similarity); Belongs to the PMEL/NMB family."},{"id":"ENSMUSP00000057494","abundance":0.174,"rank":15951,"name":"Sema5b","annotation":"Semaphorin-5B; May act as positive axonal guidance cues."},{"id":"ENSMUSP00000149339","abundance":0.173,"rank":15952,"name":"Olfr272","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000058832","abundance":0.173,"rank":15953,"name":"Spice1","annotation":"Spindle and centriole-associated protein 1; Regulator required for centriole duplication, for proper bipolar spindle formation and chromosome congression in mitosis."},{"id":"ENSMUSP00000020776","abundance":0.173,"rank":15954,"name":"Ccdc117","annotation":"Coiled-coil domain-containing protein 117."},{"id":"ENSMUSP00000027517","abundance":0.173,"rank":15955,"name":"Dgkd","annotation":"Diacylglycerol kinase."},{"id":"ENSMUSP00000143255","abundance":0.173,"rank":15956,"name":"Frrs1","annotation":"Ferric-chelate reductase 1; Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm."},{"id":"ENSMUSP00000096508","abundance":0.173,"rank":15957,"name":"4930467E23Rik","annotation":"RIKEN cDNA 4930467E23 gene."},{"id":"ENSMUSP00000081059","abundance":0.173,"rank":15958,"name":"Gm15319","annotation":"Predicted gene 15319."},{"id":"ENSMUSP00000137434","abundance":0.173,"rank":15959,"name":"Gm21119","annotation":"Predicted gene, 21119."},{"id":"ENSMUSP00000131841","abundance":0.173,"rank":15960,"name":"Zfp839","annotation":"Zinc finger protein 839."},{"id":"ENSMUSP00000032362","abundance":0.173,"rank":15961,"name":"Slco1c1","annotation":"Solute carrier organic anion transporter family member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), estradiol- 17-beta-glucuronide, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency (By similarity). May play a significant role in regulating T4 flux into and out of the brain (By similarity)."},{"id":"ENSMUSP00000128839","abundance":0.173,"rank":15962,"name":"Gm8362","annotation":"Predicted gene 8362."},{"id":"ENSMUSP00000006893","abundance":0.173,"rank":15963,"name":"D130043K22Rik","annotation":"Dyslexia-associated protein KIAA0319 homolog; Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites (By similarity)."},{"id":"ENSMUSP00000028897","abundance":0.173,"rank":15964,"name":"Cpxm1","annotation":"Probable carboxypeptidase X1; May be involved in cell-cell interactions. No carboxypeptidase activity was found yet."},{"id":"ENSMUSP00000040946","abundance":0.172,"rank":15965,"name":"Ankib1","annotation":"Ankyrin repeat and IBR domain-containing protein 1; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates."},{"id":"ENSMUSP00000100933","abundance":0.172,"rank":15966,"name":"Nr1h4","annotation":"Bile acid receptor; Ligand-activated transcription factor. Receptor for bile acids (BAs) such as chenodeoxycholic acid (CDCA), lithocholic acid, deoxycholic acid (DCA) and allocholic acid (ACA). Plays a essential role in BA homeostasis through the regulation of genes involved in BA synthesis, conjugation and enterohepatic circulation. Also regulates lipid and glucose homeostasis and is involved in innate immune response. The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in [...] "},{"id":"ENSMUSP00000151654","abundance":0.172,"rank":15967,"name":"Mindy4b-ps","annotation":"MINDY lysine 48 deubiquitinase 4B, pseudogene."},{"id":"ENSMUSP00000151219","abundance":0.172,"rank":15968,"name":"Olfr1335","annotation":"Olfactory receptor 1335."},{"id":"ENSMUSP00000150860","abundance":0.172,"rank":15969,"name":"Olfr1232","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000147547","abundance":0.172,"rank":15970,"name":"Gm7579","annotation":"Predicted gene 7579."},{"id":"ENSMUSP00000080808","abundance":0.172,"rank":15971,"name":"Fat3","annotation":"Protocadherin Fat 3; May play a role in the interactions between neurites derived from specific subsets of neurons during development."},{"id":"ENSMUSP00000030420","abundance":0.172,"rank":15972,"name":"Epha8","annotation":"Ephrin type-A receptor 8; Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin sub [...] "},{"id":"ENSMUSP00000140772","abundance":0.171,"rank":15973,"name":"CN725425","annotation":"cDNA sequence CN725425."},{"id":"ENSMUSP00000024171","abundance":0.171,"rank":15974,"name":"Stk31","annotation":"Serine/threonine-protein kinase 31."},{"id":"ENSMUSP00000128387","abundance":0.171,"rank":15975,"name":"Hectd2","annotation":"Probable E3 ubiquitin-protein ligase HECTD2; Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates."},{"id":"ENSMUSP00000001451","abundance":0.171,"rank":15976,"name":"Smg5","annotation":"Protein SMG5; Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity)."},{"id":"ENSMUSP00000027137","abundance":0.171,"rank":15977,"name":"Slc40a1","annotation":"Solute carrier family 40 member 1; May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin)."},{"id":"ENSMUSP00000059545","abundance":0.17,"rank":15978,"name":"Cyp4x1","annotation":"Cytochrome P450 4X1; A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of the last double bond of the arachidonoyl moiety of anandamide, potentially modulating endocannabinoid signaling. Has no hydroxylase activity toward various fatty acids, steroids and prostaglandins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)."},{"id":"ENSMUSP00000095555","abundance":0.17,"rank":15979,"name":"Krtap5-5","annotation":"Keratin-associated protein 5-5; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 5 family."},{"id":"ENSMUSP00000045077","abundance":0.17,"rank":15980,"name":"Nlrp2","annotation":"NLR family, pyrin domain-containing 2."},{"id":"ENSMUSP00000104039","abundance":0.17,"rank":15981,"name":"Slc6a4","annotation":"Sodium-dependent serotonin transporter; Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily."},{"id":"ENSMUSP00000008734","abundance":0.17,"rank":15982,"name":"Htr3b","annotation":"5-hydroxytryptamine receptor 3B; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand- gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub- subfamily."},{"id":"ENSMUSP00000033876","abundance":0.17,"rank":15983,"name":"Adgra2","annotation":"Adhesion G protein-coupled receptor A2; Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier. Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher- order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). ADGRA2- tethering function does not re [...] "},{"id":"ENSMUSP00000034365","abundance":0.17,"rank":15984,"name":"Tsnaxip1","annotation":"Translin-associated factor X-interacting protein 1; Possible role in spermatogenesis."},{"id":"ENSMUSP00000075179","abundance":0.17,"rank":15985,"name":"Rex2","annotation":"Reduced expression 2."},{"id":"ENSMUSP00000062884","abundance":0.17,"rank":15986,"name":"Gdf6","annotation":"Growth/differentiation factor 6; Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal- ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-speci [...] "},{"id":"ENSMUSP00000097301","abundance":0.169,"rank":15987,"name":"Zfp408","annotation":"Zinc finger protein 408."},{"id":"ENSMUSP00000122855","abundance":0.169,"rank":15988,"name":"Fign","annotation":"Fidgetin; ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity)."},{"id":"ENSMUSP00000019908","abundance":0.169,"rank":15989,"name":"Mtrf1l","annotation":"Peptide chain release factor 1-like, mitochondrial; Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG."},{"id":"ENSMUSP00000023911","abundance":0.169,"rank":15990,"name":"Nagpa","annotation":"N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6- phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N-acetylglucosaminyltransferases."},{"id":"ENSMUSP00000022947","abundance":0.169,"rank":15991,"name":"Matn2","annotation":"Matrilin-2; Involved in matrix assembly."},{"id":"ENSMUSP00000083385","abundance":0.168,"rank":15992,"name":"Rnasel","annotation":"2-5A-dependent ribonuclease; Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL  [...] "},{"id":"ENSMUSP00000039707","abundance":0.168,"rank":15993,"name":"Micall2","annotation":"MICAL-like protein 2; Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes [...] "},{"id":"ENSMUSP00000127748","abundance":0.168,"rank":15994,"name":"Gm8159","annotation":"Predicted gene 8159."},{"id":"ENSMUSP00000127256","abundance":0.168,"rank":15995,"name":"Gm8297","annotation":"Predicted gene 8297."},{"id":"ENSMUSP00000005413","abundance":0.168,"rank":15996,"name":"Zfp112","annotation":"Zinc finger protein 112; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000125355","abundance":0.168,"rank":15997,"name":"Phf21b","annotation":"PHD finger protein 21B."},{"id":"ENSMUSP00000029406","abundance":0.168,"rank":15998,"name":"Vmn2r1","annotation":"Vomeronasal type-2 receptor 1; Putative pheromone receptor; Belongs to the G-protein coupled receptor 3 family."},{"id":"ENSMUSP00000139269","abundance":0.167,"rank":15999,"name":"Pigb","annotation":"GPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2- GlcN-acyl-PI during GPI precursor assembly (By similarity)."},{"id":"ENSMUSP00000148997","abundance":0.167,"rank":16000,"name":"Olfr384","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000046467","abundance":0.167,"rank":16001,"name":"Rnf139","annotation":"E3 ubiquitin-protein ligase RNF139; E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor."},{"id":"ENSMUSP00000095782","abundance":0.167,"rank":16002,"name":"Trim6","annotation":"Tripartite motif-containing protein 6; E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells. Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response ; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000123963","abundance":0.167,"rank":16003,"name":"Zfp579","annotation":"Zinc finger protein 579; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000126231","abundance":0.167,"rank":16004,"name":"Gm14569","annotation":"Acrosomal protein KIAA1210."},{"id":"ENSMUSP00000136409","abundance":0.166,"rank":16005,"name":"Itpripl2","annotation":"Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2."},{"id":"ENSMUSP00000047012","abundance":0.166,"rank":16006,"name":"Fbxw8","annotation":"F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin- protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7- RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby  [...] "},{"id":"ENSMUSP00000006020","abundance":0.166,"rank":16007,"name":"Cnga2","annotation":"Cyclic nucleotide-gated olfactory channel; Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily."},{"id":"ENSMUSP00000074895","abundance":0.166,"rank":16008,"name":"Ddn","annotation":"Dendrin; Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein."},{"id":"ENSMUSP00000046003","abundance":0.166,"rank":16009,"name":"Cdc14b","annotation":"Dual specificity protein phosphatase CDC14B; Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity); Belongs to the pro [...] "},{"id":"ENSMUSP00000124475","abundance":0.165,"rank":16010,"name":"Wdr63","annotation":"WD repeat domain 63."},{"id":"ENSMUSP00000103615","abundance":0.165,"rank":16011,"name":"Gm12394","annotation":"Predicted gene 12394."},{"id":"ENSMUSP00000030042","abundance":0.165,"rank":16012,"name":"Kif12","annotation":"Kinesin-like protein KIF12."},{"id":"ENSMUSP00000024756","abundance":0.165,"rank":16013,"name":"Enpp5","annotation":"Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates. Lacks lysopholipase D activity. May play a role in neuronal cell communication (By similarity)."},{"id":"ENSMUSP00000062098","abundance":0.165,"rank":16014,"name":"Teddm1a","annotation":"Transmembrane epididymal protein 1A."},{"id":"ENSMUSP00000030536","abundance":0.165,"rank":16015,"name":"Pink1","annotation":"Serine/threonine-protein kinase PINK1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN. Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 (By similarity). Activates PRKN in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form. Required for u [...] "},{"id":"ENSMUSP00000020340","abundance":0.165,"rank":16016,"name":"Pcsk4","annotation":"Proprotein convertase subtilisin/kexin type 4; Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida. Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing  [...] "},{"id":"ENSMUSP00000114056","abundance":0.165,"rank":16017,"name":"Plekhg1","annotation":"Pleckstrin homology domain-containing, family G (with RhoGef domain) member 1."},{"id":"ENSMUSP00000064310","abundance":0.164,"rank":16018,"name":"Tmem62","annotation":"Transmembrane protein 62."},{"id":"ENSMUSP00000001720","abundance":0.164,"rank":16019,"name":"Tat","annotation":"Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity for phenylalanine. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family."},{"id":"ENSMUSP00000025500","abundance":0.164,"rank":16020,"name":"Slc27a6","annotation":"Solute carrier family 27 (fatty acid transporter), member 6."},{"id":"ENSMUSP00000117538","abundance":0.164,"rank":16021,"name":"Engase","annotation":"Cytosolic endo-beta-N-acetylglucosaminidase; Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol (By similarity)."},{"id":"ENSMUSP00000070927","abundance":0.164,"rank":16022,"name":"Wdr6","annotation":"WD repeat-containing protein 6; Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy."},{"id":"ENSMUSP00000116648","abundance":0.163,"rank":16023,"name":"Slc16a11","annotation":"Monocarboxylate transporter 11; Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane. Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids."},{"id":"ENSMUSP00000045160","abundance":0.163,"rank":16024,"name":"Acsm4","annotation":"Acyl-coenzyme A synthetase ACSM4, mitochondrial; Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (By similarity). Capable of activating medium-chain fatty acids with a preference for C6-12 fatty acids (By similarity); Belongs to the ATP-dependent AMP-binding enzyme family."},{"id":"ENSMUSP00000096343","abundance":0.163,"rank":16025,"name":"Vmn1r93","annotation":"Vomeronasal 1 receptor 93."},{"id":"ENSMUSP00000096333","abundance":0.163,"rank":16026,"name":"Vmn1r114","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000100832","abundance":0.163,"rank":16027,"name":"Vmn1r121","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000096318","abundance":0.163,"rank":16028,"name":"Vmn1r250","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000130984","abundance":0.163,"rank":16029,"name":"Lrrc4c","annotation":"Leucine-rich repeat-containing protein 4C; May promote neurite outgrowth of developing thalamic neurons."},{"id":"ENSMUSP00000153466","abundance":0.162,"rank":16030,"name":"Gm21762","annotation":"Predicted gene, 21762."},{"id":"ENSMUSP00000142107","abundance":0.162,"rank":16031,"name":"D13Ertd608e","annotation":"DNA segment, Chr 13, ERATO Doi 608,-expressed."},{"id":"ENSMUSP00000135870","abundance":0.162,"rank":16032,"name":"Fbxw10","annotation":"F-box/WD repeat-containing protein 10; Probable substrate-recognition component of a SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By similarity)."},{"id":"ENSMUSP00000123367","abundance":0.162,"rank":16033,"name":"Dennd4c","annotation":"DENN domain-containing protein 4C; Guanine nucleotide exchange factor (GEF) activating RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB10 into its active GTP-bound form. Thereby, stimulates SLC2A4/GLUT4 glucose transporter-enriched vesicles delivery to the plasma membrane in response to insulin."},{"id":"ENSMUSP00000153142","abundance":0.162,"rank":16034,"name":"Nek10","annotation":"Serine/threonine-protein kinase Nek10; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily."},{"id":"ENSMUSP00000033933","abundance":0.162,"rank":16035,"name":"Saraf","annotation":"Store-operated calcium entry-associated regulatory factor; Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions (By similar [...] "},{"id":"ENSMUSP00000022656","abundance":0.162,"rank":16036,"name":"Bora","annotation":"Protein aurora borealis; Required for the activation of AURKA at the onset of mitosis. Belongs to the BORA family."},{"id":"ENSMUSP00000072133","abundance":0.162,"rank":16037,"name":"Gm5862","annotation":"Predicted gene 5862."},{"id":"ENSMUSP00000080626","abundance":0.162,"rank":16038,"name":"Olfr1328","annotation":"Olfactory receptor 1328."},{"id":"ENSMUSP00000024779","abundance":0.162,"rank":16039,"name":"Usp49","annotation":"Ubiquitin carboxyl-terminal hydrolase 49; Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons (By similarity); Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000036359","abundance":0.161,"rank":16040,"name":"Pcdhga12","annotation":"Protocadherin gamma subfamily A, 12."},{"id":"ENSMUSP00000025940","abundance":0.161,"rank":16041,"name":"C1qtnf9","annotation":"Complement C1q and tumor necrosis factor-related protein 9; Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways."},{"id":"ENSMUSP00000082137","abundance":0.161,"rank":16042,"name":"Amigo3","annotation":"Amphoterin-induced protein 3; May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity); Belongs to the immunoglobulin superfamily. AMIGO family."},{"id":"ENSMUSP00000032398","abundance":0.161,"rank":16043,"name":"Thumpd3","annotation":"THUMP domain-containing protein 3; Belongs to the methyltransferase superfamily."},{"id":"ENSMUSP00000009259","abundance":0.161,"rank":16044,"name":"Spatc1l","annotation":"Speriolin-like protein; Belongs to the speriolin family."},{"id":"ENSMUSP00000051479","abundance":0.161,"rank":16045,"name":"Aff4","annotation":"AF4/FMR2 family member 4; Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity); Belongs to the AF4 family."},{"id":"ENSMUSP00000136600","abundance":0.161,"rank":16046,"name":"Gm16427","annotation":"Predicted gene 16427."},{"id":"ENSMUSP00000138982","abundance":0.161,"rank":16047,"name":"Mphosph9","annotation":"M-phase phosphoprotein 9."},{"id":"ENSMUSP00000058156","abundance":0.16,"rank":16048,"name":"Fam89a","annotation":"Protein FAM89A."},{"id":"ENSMUSP00000150537","abundance":0.16,"rank":16049,"name":"Olfr1229","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000129895","abundance":0.16,"rank":16050,"name":"Vmn2r104","annotation":"Vomeronasal 2, receptor 104."},{"id":"ENSMUSP00000021547","abundance":0.16,"rank":16051,"name":"Zfyve26","annotation":"Zinc finger FYVE domain-containing protein 26; Phosphatidylinositol 3-phosphate-binding protein required for the abcission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abcission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity)."},{"id":"ENSMUSP00000134084","abundance":0.16,"rank":16052,"name":"Vmn1r247","annotation":"Vomeronasal 1 receptor 247."},{"id":"ENSMUSP00000134516","abundance":0.16,"rank":16053,"name":"Vmn1r258","annotation":"Vomeronasal 1 receptor 258."},{"id":"ENSMUSP00000131376","abundance":0.16,"rank":16054,"name":"Vmn1r126","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000028758","abundance":0.159,"rank":16055,"name":"Itpka","annotation":"Inositol-trisphosphate 3-kinase A; Belongs to the inositol phosphokinase (IPK) family."},{"id":"ENSMUSP00000141574","abundance":0.159,"rank":16056,"name":"Tdpoz8","annotation":"TD and POZ domain-containing 8."},{"id":"ENSMUSP00000114572","abundance":0.159,"rank":16057,"name":"Trdmt1","annotation":"tRNA (cytosine(38)-C(5))-methyltransferase; Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp)."},{"id":"ENSMUSP00000032169","abundance":0.159,"rank":16058,"name":"Abtb1","annotation":"Ankyrin repeat and BTB/POZ domain-containing protein 1; May act as a mediator of the PTEN growth-suppressive signaling pathway. May play a role in developmental processes (By similarity)."},{"id":"ENSMUSP00000119114","abundance":0.159,"rank":16059,"name":"Zfp369","annotation":"Neurotrophin receptor-interacting factor 2; Transcription regulator which may participate in NGFR/p75(NTR)-mediated apoptosis. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression (By similarity)."},{"id":"ENSMUSP00000068758","abundance":0.159,"rank":16060,"name":"Dnah6","annotation":"Dynein, axonemal, heavy chain 6."},{"id":"ENSMUSP00000026866","abundance":0.159,"rank":16061,"name":"Sclt1","annotation":"Sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity)."},{"id":"ENSMUSP00000097613","abundance":0.159,"rank":16062,"name":"4930444G20Rik","annotation":"RIKEN cDNA 4930444G20 gene."},{"id":"ENSMUSP00000049387","abundance":0.159,"rank":16063,"name":"Bbs10","annotation":"Bardet-Biedl syndrome 10 protein homolog; Probable molecular chaperone that assists the folding of proteins upon ATP hydrolysis. Plays a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Involved in adipogenic differentiation."},{"id":"ENSMUSP00000015460","abundance":0.159,"rank":16064,"name":"Slamf1","annotation":"Signaling lymphocytic activation molecule; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. SLAMF1-induced signal-transduction events in T-lymphocytes are different from those [...] "},{"id":"ENSMUSP00000152034","abundance":0.158,"rank":16065,"name":"Tmprss9","annotation":"Transmembrane protease serine 9; Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln-Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala-Pro-Ala-AMC are not significantly hydrolyzed (By similarity)."},{"id":"ENSMUSP00000062054","abundance":0.158,"rank":16066,"name":"Ubqln5","annotation":"Ubiquilin 5."},{"id":"ENSMUSP00000136337","abundance":0.158,"rank":16067,"name":"Tmem151b","annotation":"Transmembrane protein 151B."},{"id":"ENSMUSP00000003509","abundance":0.158,"rank":16068,"name":"St8sia6","annotation":"Alpha-2,8-sialyltransferase 8F; Prefers O-glycans to N-glycans or glycolipids as acceptor substrates. The minimal acceptor substrate is the NeuAc-alpha-2,3(6)- Gal sequence at the non-reducing end of their carbohydrate groups."},{"id":"ENSMUSP00000030724","abundance":0.157,"rank":16069,"name":"Sesn2","annotation":"Sestrin-2; Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcripti [...] "},{"id":"ENSMUSP00000131334","abundance":0.157,"rank":16070,"name":"Gm21103","annotation":"Predicted gene, 21103."},{"id":"ENSMUSP00000132165","abundance":0.157,"rank":16071,"name":"Gm3047","annotation":"Predicted gene 3047."},{"id":"ENSMUSP00000044624","abundance":0.157,"rank":16072,"name":"Arhgap29","annotation":"Rho GTPase-activating protein 29; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis."},{"id":"ENSMUSP00000037915","abundance":0.157,"rank":16073,"name":"Dennd4a","annotation":"DENN/MADD domain-containing 4A."},{"id":"ENSMUSP00000019920","abundance":0.157,"rank":16074,"name":"Clvs2","annotation":"Clavesin-2; Required for normal morphology of late endosomes and/or lysosomes in neurons. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity)."},{"id":"ENSMUSP00000156723","abundance":0.157,"rank":16075,"name":"Setd4","annotation":"SET domain-containing protein 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family."},{"id":"ENSMUSP00000127520","abundance":0.157,"rank":16076,"name":"Gm17019","annotation":"Predicted gene 17019."},{"id":"ENSMUSP00000037023","abundance":0.157,"rank":16077,"name":"Slc38a7","annotation":"Putative sodium-coupled neutral amino acid transporter 7; Mediates sodium-dependent transport of amino acids. Substrate preference is ranked l-glutamine > l-histidine > l-serine > l-alanine > l-asparagine > l-aspartic acid > l-glutamic acid > l-methionine > l- leucine > l-glycine."},{"id":"ENSMUSP00000055130","abundance":0.156,"rank":16078,"name":"Evc2","annotation":"Limbin; Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Plays a critical role in bone formation and skeletal development. May be involved in early embryonic morphogenesis."},{"id":"ENSMUSP00000112972","abundance":0.156,"rank":16079,"name":"Prss53","annotation":"Serine protease 53; In vitro can degrade the fibrinogen alpha chain of as well as pro-urokinase-type plasminogen activator; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000115356","abundance":0.156,"rank":16080,"name":"Aldh3b2","annotation":"Aldehyde dehydrogenase family 3 member B2; Oxidizes medium and long chain aldehydes into non-toxic fatty acids; Belongs to the aldehyde dehydrogenase family."},{"id":"ENSMUSP00000095873","abundance":0.156,"rank":16081,"name":"Klhl40","annotation":"Kelch-like protein 40; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. The BCR(KLHL40) complex acts by mediating ubiquitination and degradation of TFDP1, thereby regulating the activity of the E2F:DP transcription factor complex. Promotes stabilization of LMOD3 by acting as a negative regulator of LMOD3 ubiquitination; the molecular process by which it negatively regulates ubiquitination of LMOD3 is however unclear."},{"id":"ENSMUSP00000079269","abundance":0.156,"rank":16082,"name":"Zfp735","annotation":"Zinc finger protein 735."},{"id":"ENSMUSP00000141482","abundance":0.155,"rank":16083,"name":"Pcdhga2","annotation":"Protocadherin gamma subfamily A, 2."},{"id":"ENSMUSP00000049296","abundance":0.155,"rank":16084,"name":"Pkd1","annotation":"Polycystin-1; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Both PKD1 and PKD2 are required for channel activity (By similarity). Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback  [...] "},{"id":"ENSMUSP00000140116","abundance":0.155,"rank":16085,"name":"Apbb1","annotation":"Amyloid-beta A4 precursor protein-binding family B member 1; Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to [...] "},{"id":"ENSMUSP00000130004","abundance":0.155,"rank":16086,"name":"Zfp236","annotation":"Zinc finger protein 236."},{"id":"ENSMUSP00000158957","abundance":0.155,"rank":16087,"name":"ENSMUSP00000158957","annotation":"Uncharacterized protein."},{"id":"ENSMUSP00000050087","abundance":0.155,"rank":16088,"name":"Tesk1","annotation":"Dual specificity testis-specific protein kinase 1; Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity)."},{"id":"ENSMUSP00000029516","abundance":0.155,"rank":16089,"name":"Tchhl1","annotation":"Trichohyalin-like protein 1; Belongs to the S-100 family."},{"id":"ENSMUSP00000129411","abundance":0.155,"rank":16090,"name":"Vmn2r68","annotation":"Vomeronasal 2, receptor 68."},{"id":"ENSMUSP00000041941","abundance":0.155,"rank":16091,"name":"Zfp804a","annotation":"Zinc finger protein 804A."},{"id":"ENSMUSP00000126595","abundance":0.155,"rank":16092,"name":"Gm3149","annotation":"Predicted gene 3149."},{"id":"ENSMUSP00000144005","abundance":0.155,"rank":16093,"name":"Gm3139","annotation":"Predicted gene 3139."},{"id":"ENSMUSP00000136325","abundance":0.155,"rank":16094,"name":"LOC100041712","annotation":"PRAME family member 8-like."},{"id":"ENSMUSP00000098585","abundance":0.155,"rank":16095,"name":"Gm16513","annotation":"Predicted gene, Gm16513."},{"id":"ENSMUSP00000137294","abundance":0.155,"rank":16096,"name":"Gm3106","annotation":"Predicted gene 3106."},{"id":"ENSMUSP00000136198","abundance":0.155,"rank":16097,"name":"LOC100039010","annotation":"PRAME family member 8-like."},{"id":"ENSMUSP00000136565","abundance":0.155,"rank":16098,"name":"LOC100038995","annotation":"PRAME family member 8-like."},{"id":"ENSMUSP00000136855","abundance":0.155,"rank":16099,"name":"LOC100862202","annotation":"PRAME family member 8-like."},{"id":"ENSMUSP00000136843","abundance":0.155,"rank":16100,"name":"Gm16367","annotation":"Predicted gene 16367."},{"id":"ENSMUSP00000144382","abundance":0.155,"rank":16101,"name":"Gm3183","annotation":"Predicted gene 3183."},{"id":"ENSMUSP00000136117","abundance":0.155,"rank":16102,"name":"LOC100862115","annotation":"Predicted gene 3139."},{"id":"ENSMUSP00000143931","abundance":0.155,"rank":16103,"name":"Gm7792","annotation":"Predicted gene 7792."},{"id":"ENSMUSP00000136941","abundance":0.155,"rank":16104,"name":"LOC100862245","annotation":"PRAME family member 8-like."},{"id":"ENSMUSP00000076122","abundance":0.155,"rank":16105,"name":"Olfr345","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000012161","abundance":0.155,"rank":16106,"name":"Scarf2","annotation":"Scavenger receptor class F member 2; Probable adhesion protein, which mediates homophilic and heterophilic interactions. In contrast to SCARF1, it poorly mediates the binding and degradation of acetylated low density lipoprotein (Ac- LDL)."},{"id":"ENSMUSP00000060159","abundance":0.155,"rank":16107,"name":"Ubr3","annotation":"E3 ubiquitin-protein ligase UBR3; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N- end rule, leading to their ubiquitination and subsequent degradation. May play a role in Shh signaling by mediating the ubiquitination of Kif7. May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A. Belongs to the UBR1 family."},{"id":"ENSMUSP00000032839","abundance":0.155,"rank":16108,"name":"Det1","annotation":"DET1 homolog; Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation (By similarity)."},{"id":"ENSMUSP00000143654","abundance":0.154,"rank":16109,"name":"Rpe65","annotation":"Retinoid isomerohydrolase; Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore. Essential for the production of 11-cis retinal for both rod and cone photoreceptors. Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid. The soluble form binds vitamin A (all-tra [...] "},{"id":"ENSMUSP00000086623","abundance":0.154,"rank":16110,"name":"Cntn6","annotation":"Contactin-6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus (By similarity). Involved in motor coordination; Belongs to the immunoglobulin superfamily. Contactin family."},{"id":"ENSMUSP00000058592","abundance":0.153,"rank":16111,"name":"Pcdhb6","annotation":"Protocadherin beta-6; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain."},{"id":"ENSMUSP00000149354","abundance":0.153,"rank":16112,"name":"Olfr784","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000057398","abundance":0.153,"rank":16113,"name":"Fam221b","annotation":"Protein FAM221B."},{"id":"ENSMUSP00000059159","abundance":0.153,"rank":16114,"name":"Aspm","annotation":"Abnormal spindle-like microcephaly-associated protein homolog; Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seem to depend on its association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin  [...] "},{"id":"ENSMUSP00000041863","abundance":0.153,"rank":16115,"name":"Ap5z1","annotation":"AP-5 complex subunit zeta-1; As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport."},{"id":"ENSMUSP00000014065","abundance":0.153,"rank":16116,"name":"Clip3","annotation":"CAP-Gly domain-containing linker protein 3; Functions as a cytoplasmic linker protein. Involved in TGN- endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes (By similarity)."},{"id":"ENSMUSP00000136026","abundance":0.153,"rank":16117,"name":"Gm38394","annotation":"Zinc finger BED domain-containing protein 6; Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3' and represses transcription of IGF2. May also regulate expression of other target genes containing the binding site."},{"id":"ENSMUSP00000044038","abundance":0.153,"rank":16118,"name":"L3mbtl1","annotation":"Lethal(3)malignant brain tumor-like protein 1; Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p [...] "},{"id":"ENSMUSP00000092210","abundance":0.153,"rank":16119,"name":"Cdh19","annotation":"Cadherin 19, type 2; Cadherins are calcium-dependent cell adhesion proteins."},{"id":"ENSMUSP00000053760","abundance":0.151,"rank":16120,"name":"Zfp629","annotation":"Zinc finger protein 629; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000039121","abundance":0.151,"rank":16121,"name":"Trim62","annotation":"E3 ubiquitin-protein ligase TRIM62; E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2."},{"id":"ENSMUSP00000041899","abundance":0.151,"rank":16122,"name":"Asap3","annotation":"Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3; Promotes cell proliferation."},{"id":"ENSMUSP00000151005","abundance":0.151,"rank":16123,"name":"Olfr51","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000029712","abundance":0.151,"rank":16124,"name":"Ntrk1","annotation":"High affinity nerve growth factor receptor; Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosph [...] "},{"id":"ENSMUSP00000023509","abundance":0.151,"rank":16125,"name":"Klhl24","annotation":"Kelch-like protein 24; Controls KRT14 levels during keratinocytes differentiation. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 (By similarity). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity)."},{"id":"ENSMUSP00000030757","abundance":0.151,"rank":16126,"name":"Fbxo42","annotation":"F-box only protein 42; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation (By similarity)."},{"id":"ENSMUSP00000108521","abundance":0.151,"rank":16127,"name":"Zfand4","annotation":"AN1-type zinc finger protein 4."},{"id":"ENSMUSP00000023828","abundance":0.151,"rank":16128,"name":"Rttn","annotation":"Rotatin; Involved in the genetic cascade that governs left-right specification. Required for correct asymmetric expression of NODAL, LEFTY and PITX2 (By similarity)."},{"id":"ENSMUSP00000104764","abundance":0.151,"rank":16129,"name":"Cass4","annotation":"Cas scaffolding protein family member 4; Docking protein that plays a role in tyrosine kinase-based signaling related to cell adhesion and cell spreading. Regulates PTK2/FAK1 activity, focal adhesion integrity, and cell spreading (By similarity)."},{"id":"ENSMUSP00000133014","abundance":0.151,"rank":16130,"name":"Vmn2r72","annotation":"Vomeronasal 2, receptor 72."},{"id":"ENSMUSP00000077899","abundance":0.151,"rank":16131,"name":"Kl","annotation":"Klotho peptide; May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1; Belongs to the glycosyl hydrolase 1 family. Klotho subfamily."},{"id":"ENSMUSP00000104133","abundance":0.15,"rank":16132,"name":"Dact3","annotation":"Dapper homolog 3; May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins (By similarity). Belongs to the dapper family."},{"id":"ENSMUSP00000077611","abundance":0.15,"rank":16133,"name":"Rxfp1","annotation":"Relaxin receptor 1; Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP."},{"id":"ENSMUSP00000108923","abundance":0.15,"rank":16134,"name":"Slc22a29","annotation":"Solute carrier family 22. member 29."},{"id":"ENSMUSP00000038195","abundance":0.15,"rank":16135,"name":"9130019O22Rik","annotation":"RIKEN cDNA 9130019O22 gene."},{"id":"ENSMUSP00000027267","abundance":0.15,"rank":16136,"name":"Pms1","annotation":"Postmeiotic segregation increased 1 (S. cerevisiae)."},{"id":"ENSMUSP00000044009","abundance":0.15,"rank":16137,"name":"Grid1","annotation":"Glutamate receptor ionotropic, delta-1; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRID1 subfamily."},{"id":"ENSMUSP00000156446","abundance":0.15,"rank":16138,"name":"Emilin2","annotation":"EMILIN-2; May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. Major component of the cochlear basilar membrane (BM) which may contribute to the developmental assembly or function of the BM."},{"id":"ENSMUSP00000156533","abundance":0.149,"rank":16139,"name":"Lrrc73","annotation":"Leucine-rich repeat-containing 73."},{"id":"ENSMUSP00000052088","abundance":0.149,"rank":16140,"name":"Pou3f3","annotation":"POU domain, class 3, transcription factor 3; Transcription factor that acts synergistically with SOX11 and SOX4 (By similarity). Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT- 3')."},{"id":"ENSMUSP00000112412","abundance":0.149,"rank":16141,"name":"Klhl22","annotation":"Kelch-like protein 22; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation (By similarity). The BCR(KLHL22) ubiquitin ligase complex is also responsible for the [...] "},{"id":"ENSMUSP00000123425","abundance":0.149,"rank":16142,"name":"Lin54","annotation":"Protein lin-54 homolog; Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensu [...] "},{"id":"ENSMUSP00000046812","abundance":0.149,"rank":16143,"name":"Dmrt3","annotation":"Doublesex- and mab-3-related transcription factor 3; Probable transcription factor that plays a role in configuring the spinal circuits controlling stride in vertebrates. Involved in neuronal specification within specific subdivision of spinal cord neurons and in the development of a coordinated locomotor network controlling limb movements. May regulate transcription during sexual development; Belongs to the DMRT family."},{"id":"ENSMUSP00000038321","abundance":0.149,"rank":16144,"name":"Bdp1","annotation":"Transcription factor TFIIIB component B'' homolog; General activator of RNA polymerase III transcription. Requires for transcription from all three types of polymerase III promoters. Requires for transcription of genes with internal promoter elements and with promoter elements upstream of the initiation site (By similarity)."},{"id":"ENSMUSP00000150745","abundance":0.149,"rank":16145,"name":"Olfr1272","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000150216","abundance":0.149,"rank":16146,"name":"Olfr142","annotation":"Olfactory receptor 142; Odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000065213","abundance":0.149,"rank":16147,"name":"Adam12","annotation":"Disintegrin and metalloproteinase domain-containing protein 12; Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors."},{"id":"ENSMUSP00000092900","abundance":0.149,"rank":16148,"name":"Nxph4","annotation":"Neurexophilin; May be signaling molecules that resemble neuropeptides."},{"id":"ENSMUSP00000000910","abundance":0.148,"rank":16149,"name":"Dbh","annotation":"Soluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline."},{"id":"ENSMUSP00000056814","abundance":0.148,"rank":16150,"name":"H2-Eb2","annotation":"Histocompatibility 2, class II antigen E beta2."},{"id":"ENSMUSP00000039555","abundance":0.148,"rank":16151,"name":"Pcif1","annotation":"mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (By similarity)."},{"id":"ENSMUSP00000075884","abundance":0.148,"rank":16152,"name":"Sult2a6","annotation":"Sulfotransferase; Belongs to the sulfotransferase 1 family."},{"id":"ENSMUSP00000062638","abundance":0.148,"rank":16153,"name":"Gabra3","annotation":"Gamma-aminobutyric acid receptor subunit alpha-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub- subfamily."},{"id":"ENSMUSP00000048764","abundance":0.148,"rank":16154,"name":"Naif1","annotation":"Nuclear apoptosis-inducing factor 1; Induces apoptosis."},{"id":"ENSMUSP00000082844","abundance":0.148,"rank":16155,"name":"Tecpr1","annotation":"Tectonin beta-propeller repeat-containing protein 1; Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation (By similarity)."},{"id":"ENSMUSP00000143605","abundance":0.148,"rank":16156,"name":"Ugt8a","annotation":"2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system; Belongs to the UDP-glycosyltransferase family."},{"id":"ENSMUSP00000146720","abundance":0.148,"rank":16157,"name":"Ankrd31","annotation":"Ankyrin repeat domain-containing protein 31; Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes."},{"id":"ENSMUSP00000033153","abundance":0.147,"rank":16158,"name":"Ern2","annotation":"Serine/threonine-protein kinase/endoribonuclease IRE2; Role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis. Has no effect on 28S ribosomal RNA cleavage, unlike the corresponding human protein."},{"id":"ENSMUSP00000082646","abundance":0.147,"rank":16159,"name":"Uri1","annotation":"Unconventional prefoldin RPB5 interactor; Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region (By similarity). Belongs to the RNA polymerase II subunit 5-mediating protein family."},{"id":"ENSMUSP00000040074","abundance":0.147,"rank":16160,"name":"Dse","annotation":"Dermatan-sulfate epimerase; Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues."},{"id":"ENSMUSP00000033051","abundance":0.147,"rank":16161,"name":"Itgad","annotation":"Integrin alpha-D; Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood (By similarity)."},{"id":"ENSMUSP00000142756","abundance":0.147,"rank":16162,"name":"3110082J24Rik","annotation":"RIKEN cDNA 3110082J24 gene."},{"id":"ENSMUSP00000119912","abundance":0.146,"rank":16163,"name":"Trmt9b","annotation":"Probable tRNA methyltransferase 9B; May modifie wobble uridines in specific arginine and glutamic acid tRNAs. Acts as a tumor suppressor by promoting the expression of LIN9 (By similarity); Belongs to the methyltransferase superfamily."},{"id":"ENSMUSP00000146576","abundance":0.146,"rank":16164,"name":"Rinl","annotation":"Ras and Rab interactor-like protein; Guanine nucleotide exchange factor (GEF) for RAB5A and RAB22A that activates RAB5A and RAB22A by exchanging bound GDP for free GTP. Plays a role in endocytosis via its role in activating Rab family members."},{"id":"ENSMUSP00000045387","abundance":0.146,"rank":16165,"name":"Igdcc4","annotation":"Immunoglobulin superfamily DCC subclass member 4; Belongs to the immunoglobulin superfamily. DCC family."},{"id":"ENSMUSP00000133279","abundance":0.146,"rank":16166,"name":"Tet1","annotation":"Methylcytosine dioxygenase TET1; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcription [...] "},{"id":"ENSMUSP00000106289","abundance":0.146,"rank":16167,"name":"Zscan29","annotation":"Zinc finger SCAN domains 29."},{"id":"ENSMUSP00000148632","abundance":0.146,"rank":16168,"name":"Mroh3","annotation":"Maestro heat-like repeat family member 3."},{"id":"ENSMUSP00000060205","abundance":0.145,"rank":16169,"name":"Efcab9","annotation":"EF-hand calcium-binding domain-containing protein 9; pH-dependent Ca(2+) sensor required to activate the CatSper channel, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel."},{"id":"ENSMUSP00000141348","abundance":0.145,"rank":16170,"name":"Pcdhgb1","annotation":"Protocadherin gamma subfamily B, 1."},{"id":"ENSMUSP00000151579","abundance":0.145,"rank":16171,"name":"Kcnc2","annotation":"Potassium voltage-gated channel subfamily C member 2; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemic [...] "},{"id":"ENSMUSP00000106041","abundance":0.145,"rank":16172,"name":"Adam34","annotation":"A disintegrin and metallopeptidase domain 34."},{"id":"ENSMUSP00000142284","abundance":0.145,"rank":16173,"name":"Sema4c","annotation":"Semaphorin-4C; Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. Belongs to the semaphorin family."},{"id":"ENSMUSP00000028119","abundance":0.145,"rank":16174,"name":"Mastl","annotation":"Serine/threonine-protein kinase greatwall; Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser- 62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity hi [...] "},{"id":"ENSMUSP00000036991","abundance":0.145,"rank":16175,"name":"Trpm8","annotation":"Transient receptor potential cation channel subfamily M member 8; Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of it [...] "},{"id":"ENSMUSP00000073829","abundance":0.145,"rank":16176,"name":"Slc6a15","annotation":"Sodium-dependent neutral amino acid transporter B(0)AT2; Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched- chain amino acids, particularly leucine, valine and isoleucine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity); Belongs to the sodiu [...] "},{"id":"ENSMUSP00000155685","abundance":0.144,"rank":16177,"name":"Zfp647","annotation":"Zinc finger protein 250; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000045233","abundance":0.144,"rank":16178,"name":"Catsperg1","annotation":"Cation channel sperm-associated protein subunit gamma 1; Belongs to the CATSPERG family."},{"id":"ENSMUSP00000067689","abundance":0.144,"rank":16179,"name":"Ano9","annotation":"Anoctamin-9; Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Does not exhibit calcium- activated chloride channel (CaCC) activity (By similarity). Can inhibit the activity of ANO1 (By similarity); Belongs to the anoctamin family."},{"id":"ENSMUSP00000097331","abundance":0.144,"rank":16180,"name":"Cfap44","annotation":"Cilia- and flagella-associated protein 44; Flagellar protein involved in sperm flagellum axoneme organization and function; Belongs to the CFAP44 family."},{"id":"ENSMUSP00000091474","abundance":0.144,"rank":16181,"name":"Gpr179","annotation":"G protein-coupled receptor 179."},{"id":"ENSMUSP00000022104","abundance":0.144,"rank":16182,"name":"Tert","annotation":"Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] "},{"id":"ENSMUSP00000053223","abundance":0.144,"rank":16183,"name":"Ddi1","annotation":"Protein DDI1 homolog 1; Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity)."},{"id":"ENSMUSP00000145315","abundance":0.144,"rank":16184,"name":"Olfr808","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000157180","abundance":0.144,"rank":16185,"name":"Mettl4","annotation":"N(6)-adenine-specific DNA methyltransferase METTL4; N(6)-adenine-specific DNA methyltransferase that mediates methylation of DNA on the 6th position of adenine (N(6)- methyladenosine) and is required to regulate Polycomb silencing. N(6)-methyladenosine deposition by METTL4 triggers ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing."},{"id":"ENSMUSP00000129222","abundance":0.144,"rank":16186,"name":"Insyn2a","annotation":"Inhibitory synaptic factor 2A; Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code."},{"id":"ENSMUSP00000140107","abundance":0.143,"rank":16187,"name":"Usp40","annotation":"Ubiquitin carboxyl-terminal hydrolase 40; Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000048516","abundance":0.143,"rank":16188,"name":"Tbc1d16","annotation":"TBC1 domain family, member 16."},{"id":"ENSMUSP00000033278","abundance":0.143,"rank":16189,"name":"Mmp21","annotation":"Matrix metalloproteinase-21; Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway. Cleaves alpha-1-antitrypsin (By similarity); Belongs to the peptidase M10A family."},{"id":"ENSMUSP00000015612","abundance":0.143,"rank":16190,"name":"Notch4","annotation":"Neurogenic locus notch homolog protein 4; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May regulate branching morphogenesis in the developing vascular system."},{"id":"ENSMUSP00000109064","abundance":0.143,"rank":16191,"name":"Ccl20","annotation":"C-C motif chemokine 20; Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neu [...] "},{"id":"ENSMUSP00000110645","abundance":0.142,"rank":16192,"name":"Cnot4","annotation":"CCR4-NOT transcription complex subunit 4; Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15."},{"id":"ENSMUSP00000046199","abundance":0.142,"rank":16193,"name":"Stab1","annotation":"Stabilin-1; Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system (By similarity)."},{"id":"ENSMUSP00000025618","abundance":0.142,"rank":16194,"name":"Pcsk5","annotation":"Proprotein convertase subtilisin/kexin type 5; Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. May be responsible for the maturation of gastrointestinal peptides. May be involved in the cellular proliferation of adrenal cortex via the activation of growth factors. Belongs to the [...] "},{"id":"ENSMUSP00000078190","abundance":0.142,"rank":16195,"name":"Stox2","annotation":"Storkhead-box protein 2."},{"id":"ENSMUSP00000158775","abundance":0.142,"rank":16196,"name":"Sh3d19","annotation":"SH3 domain-containing protein 19; May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity)."},{"id":"ENSMUSP00000041579","abundance":0.142,"rank":16197,"name":"Lgi4","annotation":"Leucine-rich repeat LGI family member 4; Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation."},{"id":"ENSMUSP00000095531","abundance":0.141,"rank":16198,"name":"Kncn","annotation":"Kinocilin; May play a role in stabilizing dense microtubular networks or in vesicular trafficking."},{"id":"ENSMUSP00000089555","abundance":0.141,"rank":16199,"name":"Pcdhga9","annotation":"Protocadherin gamma subfamily A, 9."},{"id":"ENSMUSP00000038486","abundance":0.141,"rank":16200,"name":"Fam171a2","annotation":"Protein FAM171A2; Belongs to the FAM171 family."},{"id":"ENSMUSP00000149028","abundance":0.141,"rank":16201,"name":"Olfr1271","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000113042","abundance":0.141,"rank":16202,"name":"Rhpn1","annotation":"Rhophilin-1; Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules; Belongs to the RHPN family."},{"id":"ENSMUSP00000111325","abundance":0.141,"rank":16203,"name":"Gm42416","annotation":"Predicted gene, 37013."},{"id":"ENSMUSP00000033929","abundance":0.14,"rank":16204,"name":"Tnks","annotation":"Poly [ADP-ribose] polymerase tankyrase-1; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly- ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Medi [...] "},{"id":"ENSMUSP00000122543","abundance":0.14,"rank":16205,"name":"Sgsm3","annotation":"Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells."},{"id":"ENSMUSP00000136196","abundance":0.14,"rank":16206,"name":"ENSMUSP00000136196","annotation":"annotation not available"},{"id":"ENSMUSP00000141438","abundance":0.14,"rank":16207,"name":"Tmem131l","annotation":"Transmembrane protein 131-like; In its membrane-associated form, antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation."},{"id":"ENSMUSP00000017290","abundance":0.14,"rank":16208,"name":"Brca1","annotation":"Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] "},{"id":"ENSMUSP00000044932","abundance":0.14,"rank":16209,"name":"Cct8l1","annotation":"Chaperonin-containing TCP1, subunit 8 (theta)-like 1."},{"id":"ENSMUSP00000033000","abundance":0.14,"rank":16210,"name":"Il21r","annotation":"Interleukin-21 receptor; This is a receptor for interleukin-21."},{"id":"ENSMUSP00000037004","abundance":0.139,"rank":16211,"name":"Plekhg6","annotation":"Pleckstrin homology domain-containing family G member 6; Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis (By similarity)."},{"id":"ENSMUSP00000037532","abundance":0.139,"rank":16212,"name":"Colgalt2","annotation":"Procollagen galactosyltransferase 2; Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of collagen."},{"id":"ENSMUSP00000098580","abundance":0.139,"rank":16213,"name":"Cep170b","annotation":"Centrosomal protein of 170 kDa protein B; Plays a role in microtubule organization."},{"id":"ENSMUSP00000041110","abundance":0.139,"rank":16214,"name":"Nmnat2","annotation":"Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2; Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (By similarity). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (By similarity). Cannot use triazofurin monophosphate (TrMP) as substrate (By similarity). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (By similarity). For the pyrophosphorolytic a [...] "},{"id":"ENSMUSP00000152426","abundance":0.139,"rank":16215,"name":"Btbd7","annotation":"BTB/POZ domain-containing protein 7; Acts as a mediator of epithelial dynamics and organ branching by promoting cleft progression. Induced following accumulation of fibronectin in forming clefts, leading to local expression of the cell- scattering SNAIL2 and suppression of E-cadherin levels, thereby altering cell morphology and reducing cell-cell adhesion. This stimulates cell separation at the base of forming clefts by local, dynamic intercellular gap formation and promotes cleft progression."},{"id":"ENSMUSP00000099593","abundance":0.139,"rank":16216,"name":"Rasgrp1","annotation":"RAS guanyl-releasing protein 1; Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (By similarity). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic  [...] "},{"id":"ENSMUSP00000038506","abundance":0.139,"rank":16217,"name":"Fstl5","annotation":"Follistatin-related protein 5."},{"id":"ENSMUSP00000110835","abundance":0.139,"rank":16218,"name":"Telo2","annotation":"Telomere length regulation protein TEL2 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, wh [...] "},{"id":"ENSMUSP00000136636","abundance":0.138,"rank":16219,"name":"Gm20738","annotation":"Predicted gene, 20738."},{"id":"ENSMUSP00000136451","abundance":0.138,"rank":16220,"name":"Gm20823","annotation":"Predicted gene, 20738."},{"id":"ENSMUSP00000139614","abundance":0.138,"rank":16221,"name":"Gm20924","annotation":"Predicted gene, 20924."},{"id":"ENSMUSP00000035358","abundance":0.138,"rank":16222,"name":"Dstyk","annotation":"Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase- independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family."},{"id":"ENSMUSP00000063277","abundance":0.138,"rank":16223,"name":"Cemip","annotation":"Cell migration-inducing and hyaluronan-binding protein; Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tum [...] "},{"id":"ENSMUSP00000004622","abundance":0.138,"rank":16224,"name":"Gab2","annotation":"GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Belongs to the GAB family."},{"id":"ENSMUSP00000006556","abundance":0.138,"rank":16225,"name":"Mpl","annotation":"Thrombopoietin receptor; Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses. Belongs to the type I cytokine receptor family. Type 1 subfamily."},{"id":"ENSMUSP00000159165","abundance":0.137,"rank":16226,"name":"Clca4a","annotation":"Calcium-activated chloride channel regulator 4A, 110 kDa form; May be involved in mediating calcium-activated chloride conductance."},{"id":"ENSMUSP00000080442","abundance":0.137,"rank":16227,"name":"Fam214a","annotation":"Protein FAM214A."},{"id":"ENSMUSP00000129832","abundance":0.137,"rank":16228,"name":"Heatr4","annotation":"HEAT repeat-containing 4."},{"id":"ENSMUSP00000146602","abundance":0.137,"rank":16229,"name":"Arhgap33","annotation":"Rho GTPase-activating protein 33; May be involved in several stages of intracellular trafficking (By similarity). Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport; Belongs to the PX domain-containing GAP family."},{"id":"ENSMUSP00000155981","abundance":0.137,"rank":16230,"name":"Ccdc188","annotation":"Coiled-coil domain-containing 188."},{"id":"ENSMUSP00000031239","abundance":0.136,"rank":16231,"name":"Abcg3","annotation":"ATP-binding cassette sub-family G member 3."},{"id":"ENSMUSP00000019942","abundance":0.136,"rank":16232,"name":"Aig1","annotation":"Androgen-induced gene 1 protein; Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (By similarity). Shows a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (By similarity); Belongs to the AIG1 family."},{"id":"ENSMUSP00000050535","abundance":0.136,"rank":16233,"name":"Adamts19","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 19."},{"id":"ENSMUSP00000112554","abundance":0.136,"rank":16234,"name":"Sh3bp2","annotation":"SH3 domain-binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism (By similarity)."},{"id":"ENSMUSP00000141803","abundance":0.136,"rank":16235,"name":"Pcdhga6","annotation":"Protocadherin gamma subfamily A, 6."},{"id":"ENSMUSP00000125587","abundance":0.135,"rank":16236,"name":"Speer4e","annotation":"Spermatogenesis-associated glutamate (E)-rich protein 4e."},{"id":"ENSMUSP00000153413","abundance":0.135,"rank":16237,"name":"Gm21818","annotation":"Predicted gene, 21818."},{"id":"ENSMUSP00000071578","abundance":0.135,"rank":16238,"name":"Mthfd2l","annotation":"Probable bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2."},{"id":"ENSMUSP00000137348","abundance":0.135,"rank":16239,"name":"Tcstv1","annotation":"2-cell-stage, variable group, member 1."},{"id":"ENSMUSP00000151137","abundance":0.135,"rank":16240,"name":"Olfr323","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000099710","abundance":0.135,"rank":16241,"name":"Akap10","annotation":"A-kinase anchor protein 10, mitochondrial; Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain [...] "},{"id":"ENSMUSP00000094164","abundance":0.135,"rank":16242,"name":"Zhx2","annotation":"Zinc fingers and homeoboxes protein 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA (By similarity). May play a role in retinal development where it regulates the composition of bipolar cell populations, by promoting differentiation of bipolar OFF-type cells. In the brain, may promote maintenance and suppress differentiation of neural progenitor cells in the developing cortex. Belongs to the ZHX family."},{"id":"ENSMUSP00000149125","abundance":0.135,"rank":16243,"name":"Olfr1377","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000028735","abundance":0.135,"rank":16244,"name":"Jag1","annotation":"Protein jagged-1; Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). May regulate fibroblast growth factor-induced angiogenesis."},{"id":"ENSMUSP00000096482","abundance":0.135,"rank":16245,"name":"Flg2","annotation":"Filaggrin-2; Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis; Belongs to the S100-fused protein family."},{"id":"ENSMUSP00000103896","abundance":0.134,"rank":16246,"name":"Gpr160","annotation":"Probable G-protein coupled receptor 160; Orphan receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000040771","abundance":0.134,"rank":16247,"name":"Ttc7","annotation":"Tetratricopeptide repeat protein 7A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (By similarity). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity)."},{"id":"ENSMUSP00000074360","abundance":0.134,"rank":16248,"name":"Lrig3","annotation":"Leucine-rich repeats and immunoglobulin-like domains protein 3; Plays a role in craniofacial and inner ear morphogenesis during embryonic development. Acts within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1."},{"id":"ENSMUSP00000086294","abundance":0.134,"rank":16249,"name":"Espnl","annotation":"Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing."},{"id":"ENSMUSP00000089230","abundance":0.134,"rank":16250,"name":"Snrnp48","annotation":"U11/U12 small nuclear ribonucleoprotein 48 kDa protein; Likely involved in U12-type 5' splice site recognition."},{"id":"ENSMUSP00000149293","abundance":0.134,"rank":16251,"name":"Olfr385","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149667","abundance":0.134,"rank":16252,"name":"Olfr350","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000110519","abundance":0.134,"rank":16253,"name":"Usp26","annotation":"Ubiquitin carboxyl-terminal hydrolase 26; Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway. Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000027843","abundance":0.133,"rank":16254,"name":"Fmo9","annotation":"Dimethylaniline monooxygenase [N-oxide-forming]."},{"id":"ENSMUSP00000023119","abundance":0.133,"rank":16255,"name":"Vdr","annotation":"Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity)."},{"id":"ENSMUSP00000112833","abundance":0.133,"rank":16256,"name":"Card6","annotation":"Caspase recruitment domain family, member 6."},{"id":"ENSMUSP00000119482","abundance":0.133,"rank":16257,"name":"Kif26a","annotation":"Kinesin-like protein KIF26A; Atypical kinesin that plays a key role in enteric neuron development. Acts by repressing a cell growth signaling pathway in the enteric nervous system development, possibly via its interaction with GRB2 that prevents GRB2-binding to SHC, thereby attenating the GDNF-Ret signaling. Binds to microtubules but lacks microtubule-based motility due to the absence of ATPase activity."},{"id":"ENSMUSP00000042028","abundance":0.133,"rank":16258,"name":"Apobr","annotation":"Apolipoprotein B receptor; Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG-VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macr [...] "},{"id":"ENSMUSP00000131831","abundance":0.133,"rank":16259,"name":"Vmn2r6","annotation":"Vomeronasal 2, receptor 6."},{"id":"ENSMUSP00000131109","abundance":0.133,"rank":16260,"name":"Gm8180","annotation":"Predicted gene 8180."},{"id":"ENSMUSP00000119609","abundance":0.133,"rank":16261,"name":"Mmrn1","annotation":"Multimerin-1; Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein (By similarity)."},{"id":"ENSMUSP00000010127","abundance":0.132,"rank":16262,"name":"Tktl1","annotation":"Transketolase-like protein 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate; Belongs to the transketolase family."},{"id":"ENSMUSP00000034478","abundance":0.132,"rank":16263,"name":"St14","annotation":"Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (By similarity)."},{"id":"ENSMUSP00000096672","abundance":0.132,"rank":16264,"name":"Ripor3","annotation":"RIPOR family member 3; Belongs to the RIPOR family."},{"id":"ENSMUSP00000155119","abundance":0.132,"rank":16265,"name":"Gm49496","annotation":"Predicted gene, 49496."},{"id":"ENSMUSP00000158705","abundance":0.132,"rank":16266,"name":"Sptbn5","annotation":"Spectrin beta, non-erythrocytic 5."},{"id":"ENSMUSP00000127318","abundance":0.132,"rank":16267,"name":"Lpcat2b","annotation":"Lysophosphatidylcholine acyltransferase 2B; Probable acetyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family."},{"id":"ENSMUSP00000128823","abundance":0.132,"rank":16268,"name":"Gm17349","annotation":"Predicted gene, 17349."},{"id":"ENSMUSP00000157880","abundance":0.132,"rank":16269,"name":"Tigd3","annotation":"Tigger transposable element-derived protein 3."},{"id":"ENSMUSP00000096149","abundance":0.131,"rank":16270,"name":"Clca4b","annotation":"Chloride channel calcium activated 7."},{"id":"ENSMUSP00000051331","abundance":0.131,"rank":16271,"name":"Axin2","annotation":"Axin-2; Inhibitor of the Wnt signaling pathway. Down-regulates beta- catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B."},{"id":"ENSMUSP00000103815","abundance":0.131,"rank":16272,"name":"Bach2","annotation":"Transcription regulator protein BACH2; Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Plays an important role in coordinating transcription activation and repression by MAFK. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (By similarity). Positively regulates the nuclear import of actin. Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation ; Belongs to the bZIP family. CNC subfamily."},{"id":"ENSMUSP00000037096","abundance":0.131,"rank":16273,"name":"Lrrn1","annotation":"Leucine-rich repeat neuronal protein 1."},{"id":"ENSMUSP00000005334","abundance":0.131,"rank":16274,"name":"Shbg","annotation":"Sex hormone-binding globulin; Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration (By similarity)."},{"id":"ENSMUSP00000139397","abundance":0.131,"rank":16275,"name":"Lrcol1","annotation":"Leucine-rich colipase-like protein 1."},{"id":"ENSMUSP00000112421","abundance":0.131,"rank":16276,"name":"Slc28a1","annotation":"Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family."},{"id":"ENSMUSP00000102382","abundance":0.131,"rank":16277,"name":"Mroh7","annotation":"Maestro heat-like repeat-containing protein family member 7."},{"id":"ENSMUSP00000046584","abundance":0.13,"rank":16278,"name":"Plcl2","annotation":"Inactive phospholipase C-like protein 2; May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum."},{"id":"ENSMUSP00000033207","abundance":0.13,"rank":16279,"name":"Zp2","annotation":"Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor."},{"id":"ENSMUSP00000000809","abundance":0.13,"rank":16280,"name":"Slc5a5","annotation":"Sodium/iodide cotransporter; Mediates iodide uptake in the thyroid gland; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family."},{"id":"ENSMUSP00000020753","abundance":0.13,"rank":16281,"name":"Clhc1","annotation":"Clathrin heavy chain linker domain-containing protein 1."},{"id":"ENSMUSP00000037246","abundance":0.13,"rank":16282,"name":"Igsf10","annotation":"Immunoglobulin superfamily member 10; Involved in the control of early migration of neurons expressing gonadotropin-releasing hormone (GNRH neurons). May be involved in the maintenance of osteochondroprogenitor cells pool (By similarity)."},{"id":"ENSMUSP00000064934","abundance":0.13,"rank":16283,"name":"Cd177","annotation":"CD177 antigen; In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (By similarity). In addition, by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (By similarity). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (By similarity). However, appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo.  [...] "},{"id":"ENSMUSP00000090839","abundance":0.13,"rank":16284,"name":"9930111J21Rik2","annotation":"Interferon-gamma-inducible GTPase Ifggb1 protein."},{"id":"ENSMUSP00000140639","abundance":0.13,"rank":16285,"name":"Gm5157","annotation":"Predicted gene 5157; Belongs to the protein kinase superfamily."},{"id":"ENSMUSP00000080881","abundance":0.13,"rank":16286,"name":"Jakmip2","annotation":"Janus kinase and microtubule-interacting protein 2."},{"id":"ENSMUSP00000104878","abundance":0.13,"rank":16287,"name":"Prickle1","annotation":"Prickle-like protein 1; Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure (By similarity). Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor (By similarity)."},{"id":"ENSMUSP00000126629","abundance":0.129,"rank":16288,"name":"Zfp516","annotation":"Zinc finger protein 516; Transcriptional regulator that binds to the promoter and activates the transcription of genes promoting brown adipose tissue (BAT) differentiation. Among brown adipose tissue-specific genes, binds the proximal region of the promoter of the UCP1 gene to activate its transcription and thereby regulate thermogenesis. May also play a role in the cellular response to replication stress (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000073190","abundance":0.129,"rank":16289,"name":"Lct","annotation":"Lactase."},{"id":"ENSMUSP00000028527","abundance":0.129,"rank":16290,"name":"Kif18a","annotation":"Kinesin-like protein KIF18A; Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression (By similarity)."},{"id":"ENSMUSP00000144706","abundance":0.128,"rank":16291,"name":"Naaladl2","annotation":"N-acetylated alpha-linked acidic dipeptidase-like 2."},{"id":"ENSMUSP00000095007","abundance":0.128,"rank":16292,"name":"Gm3435","annotation":"Predicted gene 3435."},{"id":"ENSMUSP00000158841","abundance":0.128,"rank":16293,"name":"Mgam2-ps","annotation":"Maltase-glucoamylase 2, pseudogene."},{"id":"ENSMUSP00000029623","abundance":0.128,"rank":16294,"name":"Tlr2","annotation":"Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface [...] "},{"id":"ENSMUSP00000085013","abundance":0.128,"rank":16295,"name":"Ephx3","annotation":"Epoxide hydrolase 3; Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9- EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin. Belongs to the AB hydrolase superfamily. Epoxide hydrolase family."},{"id":"ENSMUSP00000025856","abundance":0.128,"rank":16296,"name":"Lrp5","annotation":"Low-density lipoprotein receptor-related protein 5; Acts as a coreceptor with members of the frizzled family of seven-transmembrane spanning receptors to transduce signal by Wnt proteins. Activates the canonical Wnt signaling pathway that controls cell fate determination and self-renewal during embryonic development and adult tissue regeneration. In particular, may play an important role in the development of the posterior patterning of the epiblast during gastrulation. During bone development, regulates osteoblast proliferation and differentiation thus determining bone mass. Mechanist [...] "},{"id":"ENSMUSP00000035535","abundance":0.128,"rank":16297,"name":"Hirip3","annotation":"HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones."},{"id":"ENSMUSP00000141893","abundance":0.127,"rank":16298,"name":"Pcdhga5","annotation":"Protocadherin gamma subfamily A, 5."},{"id":"ENSMUSP00000091440","abundance":0.127,"rank":16299,"name":"Tmem94","annotation":"Transmembrane protein 94."},{"id":"ENSMUSP00000141043","abundance":0.127,"rank":16300,"name":"Gm21761","annotation":"Predicted gene, 21761."},{"id":"ENSMUSP00000136309","abundance":0.127,"rank":16301,"name":"AF067061","annotation":"cDNA sequence AF067061."},{"id":"ENSMUSP00000152988","abundance":0.127,"rank":16302,"name":"Gm20767","annotation":"Predicted gene, 20767."},{"id":"ENSMUSP00000027393","abundance":0.127,"rank":16303,"name":"Bard1","annotation":"BRCA1-associated RING domain protein 1; E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II [...] "},{"id":"ENSMUSP00000155034","abundance":0.127,"rank":16304,"name":"Mgrn1","annotation":"E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). Acts also as a negative regulator of hedgehog signaling."},{"id":"ENSMUSP00000043818","abundance":0.127,"rank":16305,"name":"Lrrn3","annotation":"Leucine-rich repeat neuronal protein 3."},{"id":"ENSMUSP00000101706","abundance":0.127,"rank":16306,"name":"Zzz3","annotation":"ZZ-type zinc finger-containing protein 3; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4."},{"id":"ENSMUSP00000031690","abundance":0.127,"rank":16307,"name":"Hyal6","annotation":"Hyaluronidase."},{"id":"ENSMUSP00000058256","abundance":0.127,"rank":16308,"name":"Adam26a","annotation":"Disintegrin and metalloproteinase domain-containing protein 26A; Sperm surface membrane protein that may be involved in spermatogenesis and fertilization."},{"id":"ENSMUSP00000095234","abundance":0.127,"rank":16309,"name":"Gal3st2c","annotation":"Galactose-3-O-sulfotransferase 2C."},{"id":"ENSMUSP00000053908","abundance":0.127,"rank":16310,"name":"Ston2","annotation":"Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating (By similarity)."},{"id":"ENSMUSP00000079909","abundance":0.127,"rank":16311,"name":"Sycp2","annotation":"Synaptonemal complex protein 2; Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. Plays a role in the assembly of synaptonemal complexes. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. Required for insertion of SYCP3 into synaptonemal complexes. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements. Belongs [...] "},{"id":"ENSMUSP00000147202","abundance":0.126,"rank":16312,"name":"Gm45194","annotation":"Predicted gene 45194."},{"id":"ENSMUSP00000149438","abundance":0.126,"rank":16313,"name":"Olfr1148","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000045445","abundance":0.126,"rank":16314,"name":"Mllt6","annotation":"Myeloid/lymphoid or mixed-lineage leukemia; translocated to, 6."},{"id":"ENSMUSP00000088056","abundance":0.126,"rank":16315,"name":"Ptprz1","annotation":"Receptor-type tyrosine-protein phosphatase zeta; Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades. Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily."},{"id":"ENSMUSP00000092250","abundance":0.126,"rank":16316,"name":"Gal3st2","annotation":"Galactose-3-O-sulfotransferase 2."},{"id":"ENSMUSP00000147120","abundance":0.126,"rank":16317,"name":"Gm4565","annotation":"Predicted gene 4565."},{"id":"ENSMUSP00000147065","abundance":0.126,"rank":16318,"name":"Gm4513","annotation":"Predicted gene 4513; Belongs to the protein kinase superfamily."},{"id":"ENSMUSP00000140400","abundance":0.126,"rank":16319,"name":"Gm6902","annotation":"Predicted gene 6902."},{"id":"ENSMUSP00000147031","abundance":0.126,"rank":16320,"name":"Gm6176","annotation":"Predicted gene 6176; Belongs to the protein kinase superfamily."},{"id":"ENSMUSP00000140310","abundance":0.126,"rank":16321,"name":"Gm4567","annotation":"Predicted gene, EG381936; Belongs to the protein kinase superfamily."},{"id":"ENSMUSP00000140440","abundance":0.126,"rank":16322,"name":"Gm10668","annotation":"Predicted gene 10668."},{"id":"ENSMUSP00000131605","abundance":0.125,"rank":16323,"name":"Gm4302","annotation":"Predicted gene 4302."},{"id":"ENSMUSP00000113216","abundance":0.125,"rank":16324,"name":"Depdc1a","annotation":"DEP domain-containing protein 1A; May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells (By similarity)."},{"id":"ENSMUSP00000029222","abundance":0.125,"rank":16325,"name":"Ccdc39","annotation":"Coiled-coil domain-containing protein 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with CCDC40 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Not required for outer dynein arm complexes assembly."},{"id":"ENSMUSP00000136012","abundance":0.125,"rank":16326,"name":"Gal3st2b","annotation":"Galactose-3-O-sulfotransferase 2; Transfers a sulfate group to the hydroxyl group at C3 of non- reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3- GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency (By similarity); Belongs to the galactose-3-O-sulfotransferase family."},{"id":"ENSMUSP00000120007","abundance":0.124,"rank":16327,"name":"Dync2h1","annotation":"Cytoplasmic dynein 2 heavy chain 1; May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. According to it may play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells."},{"id":"ENSMUSP00000143486","abundance":0.124,"rank":16328,"name":"Tex13c2","annotation":"TEX13 family member C2."},{"id":"ENSMUSP00000150582","abundance":0.124,"rank":16329,"name":"Olfr551","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000081665","abundance":0.123,"rank":16330,"name":"Anks6","annotation":"Ankyrin repeat and SAM domain-containing protein 6; Required for renal function."},{"id":"ENSMUSP00000023206","abundance":0.123,"rank":16331,"name":"Ercc4","annotation":"DNA repair endonuclease XPF; Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link (By similarity); Belongs to the XPF family."},{"id":"ENSMUSP00000135881","abundance":0.123,"rank":16332,"name":"Prox2","annotation":"Prospero homeobox protein 2; Transcription regulator. Does not seem to be essential for embryonic development and postnatal survival. Belongs to the Prospero homeodomain family."},{"id":"ENSMUSP00000067728","abundance":0.123,"rank":16333,"name":"Pcdhga8","annotation":"Protocadherin gamma subfamily A, 8."},{"id":"ENSMUSP00000151398","abundance":0.123,"rank":16334,"name":"Gm4305","annotation":"Predicted gene 4305."},{"id":"ENSMUSP00000151319","abundance":0.123,"rank":16335,"name":"Gm4303","annotation":"Predicted gene 4303."},{"id":"ENSMUSP00000135905","abundance":0.123,"rank":16336,"name":"Gm4307","annotation":"Predicted gene 4303."},{"id":"ENSMUSP00000150120","abundance":0.123,"rank":16337,"name":"Olfr1121","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000019965","abundance":0.123,"rank":16338,"name":"Smpd2","annotation":"Sphingomyelin phosphodiesterase 2; Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2-lyso- sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso-sn-glycero- 3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF (By similarity); Belongs to the neutral sphingomyelinase family."},{"id":"ENSMUSP00000028256","abundance":0.123,"rank":16339,"name":"Morn5","annotation":"MORN repeat-containing protein 5."},{"id":"ENSMUSP00000045490","abundance":0.123,"rank":16340,"name":"Vps13b","annotation":"Vacuolar protein sorting-associated protein 13B; May be involved in protein sorting in post Golgi membrane traffic; Belongs to the VPS13 family."},{"id":"ENSMUSP00000037586","abundance":0.122,"rank":16341,"name":"Gpr176","annotation":"G-protein coupled receptor 176; Orphan receptor involved in normal circadian rhythm behavior. Acts through the G-protein subclass G(z)-alpha and has an agonist-independent basal activity to repress cAMP production."},{"id":"ENSMUSP00000027431","abundance":0.122,"rank":16342,"name":"Htr2b","annotation":"5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of [...] "},{"id":"ENSMUSP00000133201","abundance":0.122,"rank":16343,"name":"Gm3159","annotation":"Predicted gene 3159."},{"id":"ENSMUSP00000138103","abundance":0.122,"rank":16344,"name":"Rassf10","annotation":"Ras association domain-containing protein 10; Plays an important role in regulating embryonic neurogenesis."},{"id":"ENSMUSP00000043115","abundance":0.122,"rank":16345,"name":"Heatr5a","annotation":"HEAT repeat-containing protein 5A."},{"id":"ENSMUSP00000069259","abundance":0.122,"rank":16346,"name":"Pias3","annotation":"E3 SUMO-protein ligase PIAS3; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Repressor of MITF transcriptional activity. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 wh [...] "},{"id":"ENSMUSP00000034566","abundance":0.122,"rank":16347,"name":"Dixdc1","annotation":"Dixin; Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2."},{"id":"ENSMUSP00000146622","abundance":0.121,"rank":16348,"name":"Gm5890","annotation":"Predicted gene 5890; Belongs to the protein kinase superfamily."},{"id":"ENSMUSP00000134331","abundance":0.121,"rank":16349,"name":"Cyp2j7","annotation":"Cytochrome P450, family 2, subfamily j, polypeptide 7; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000036148","abundance":0.121,"rank":16350,"name":"Mroh2b","annotation":"Maestro heat-like repeat-containing protein family member 2B; May play a role in the process of sperm capacitation."},{"id":"ENSMUSP00000053742","abundance":0.12,"rank":16351,"name":"Pcsk6","annotation":"Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family."},{"id":"ENSMUSP00000116103","abundance":0.12,"rank":16352,"name":"Nol12","annotation":"Nucleolar protein 12; May bind to 28S rRNA. In vitro binds single-stranded nucleic acids."},{"id":"ENSMUSP00000124942","abundance":0.12,"rank":16353,"name":"Spopfm2","annotation":"Speckle-type BTB/POZ protein family member 2."},{"id":"ENSMUSP00000038675","abundance":0.12,"rank":16354,"name":"Lrrd1","annotation":"Leucine-rich repeat and death domain-containing protein 1."},{"id":"ENSMUSP00000089513","abundance":0.12,"rank":16355,"name":"Prdm6","annotation":"Putative histone-lysine N-methyltransferase PRDM6; Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone meth [...] "},{"id":"ENSMUSP00000027874","abundance":0.12,"rank":16356,"name":"Sele","annotation":"E-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis."},{"id":"ENSMUSP00000096773","abundance":0.12,"rank":16357,"name":"Gm1527","annotation":"Predicted gene 1527."},{"id":"ENSMUSP00000045217","abundance":0.12,"rank":16358,"name":"Fanca","annotation":"Fanconi anemia group A protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity)."},{"id":"ENSMUSP00000060857","abundance":0.119,"rank":16359,"name":"9030025P20Rik","annotation":"RIKEN cDNA 9030025P20 gene."},{"id":"ENSMUSP00000067049","abundance":0.119,"rank":16360,"name":"Zfp438","annotation":"Zinc finger protein 438."},{"id":"ENSMUSP00000015498","abundance":0.119,"rank":16361,"name":"Pcolce2","annotation":"Procollagen C-endopeptidase enhancer 2; Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1."},{"id":"ENSMUSP00000075788","abundance":0.119,"rank":16362,"name":"Gpr155","annotation":"G protein-coupled receptor 155."},{"id":"ENSMUSP00000129974","abundance":0.119,"rank":16363,"name":"Ctif","annotation":"CBP80/20-dependent translation initiation factor; Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the p [...] "},{"id":"ENSMUSP00000119872","abundance":0.119,"rank":16364,"name":"Tmem63c","annotation":"Calcium permeable stress-gated cation channel 1; Acts as an osmosensitive calcium-permeable cation channel. Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). Belongs to the CSC1 (TC 1.A.17) family."},{"id":"ENSMUSP00000099071","abundance":0.118,"rank":16365,"name":"Dgki","annotation":"Diacylglycerol kinase."},{"id":"ENSMUSP00000093729","abundance":0.118,"rank":16366,"name":"Psd","annotation":"PH and SEC7 domain-containing protein 1; Guanine nucleotide exchange factor for ARF6 (By similarity). Isoform 2 and isoform 3 induce cytoskeletal remodeling, but lead to distinct morphological changes in HeLa cells: isoform 2 induces cell elongation and formation of actin-rich protrusions, whereas isoform 3 promotes the formation of membrane ruffles and loss of stress fibers."},{"id":"ENSMUSP00000112538","abundance":0.118,"rank":16367,"name":"Abca17","annotation":"ATP-binding cassette sub-family A member 17; Promotes cholesterol efflux from sperm which renders sperm capable of fertilization. Has also been shown to decrease levels of intracellular esterified neutral lipids including cholesteryl esters, fatty acid esters and triacylglycerols."},{"id":"ENSMUSP00000136515","abundance":0.117,"rank":16368,"name":"Gm960","annotation":"Type 2 DNA topoisomerase 6 subunit B-like; Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with SPO11, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles; Belongs to the TOP6B-like family."},{"id":"ENSMUSP00000097025","abundance":0.117,"rank":16369,"name":"Spata31","annotation":"Spermatogenesis-associated protein 31; May play a role in spermatogenesis."},{"id":"ENSMUSP00000151829","abundance":0.117,"rank":16370,"name":"Galnt16","annotation":"Polypeptide N-acetylgalactosaminyltransferase 16; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor."},{"id":"ENSMUSP00000153496","abundance":0.117,"rank":16371,"name":"Tcstv3","annotation":"2-cell-stage, variable group, member 3."},{"id":"ENSMUSP00000032736","abundance":0.117,"rank":16372,"name":"Mtmr10","annotation":"Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily."},{"id":"ENSMUSP00000033053","abundance":0.117,"rank":16373,"name":"Itgax","annotation":"Integrin alpha-X; Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis (By similarity)."},{"id":"ENSMUSP00000133898","abundance":0.117,"rank":16374,"name":"Arhgap32","annotation":"Rho GTPase-activating protein 32; GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity."},{"id":"ENSMUSP00000140827","abundance":0.117,"rank":16375,"name":"Ace3","annotation":"Angiotensin-converting enzyme-like protein Ace3; Belongs to the peptidase M2 family."},{"id":"ENSMUSP00000141359","abundance":0.117,"rank":16376,"name":"Pcdhga10","annotation":"Protocadherin gamma subfamily A, 10."},{"id":"ENSMUSP00000122058","abundance":0.116,"rank":16377,"name":"Bbs9","annotation":"Protein PTHB1; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF [...] "},{"id":"ENSMUSP00000095149","abundance":0.116,"rank":16378,"name":"Cep76","annotation":"Centrosomal protein of 76 kDa; Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication (By similarity)."},{"id":"ENSMUSP00000002976","abundance":0.115,"rank":16379,"name":"Il17ra","annotation":"Interleukin-17 receptor A; Receptor for IL17A. Receptor for IL17F. Binds to IL17A with higher affinity than to IL17F. Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE. Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (By similarity)."},{"id":"ENSMUSP00000027394","abundance":0.115,"rank":16380,"name":"Zfand2b","annotation":"AN1-type zinc finger protein 2B; Plays a role in protein homeostasis by regulating both the translocation and the ubiquitin-mediated proteasomal degradation of nascent proteins at the endoplasmic reticulum. It is involved in the regulation of signal-mediated translocation of proteins into the endoplasmic reticulum. It also plays a role in the ubiquitin- mediated proteasomal degradation of proteins for which signal-mediated translocation to the endoplasmic reticulum has failed. May therefore function in the endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism th [...] "},{"id":"ENSMUSP00000021044","abundance":0.115,"rank":16381,"name":"5530401A14Rik","annotation":"RIKEN cDNA 5530401A14 gene."},{"id":"ENSMUSP00000125063","abundance":0.115,"rank":16382,"name":"Cacna1i","annotation":"Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the \"low-voltage activated (LVA)\" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] "},{"id":"ENSMUSP00000000811","abundance":0.115,"rank":16383,"name":"Kcnn3","annotation":"Small conductance calcium-activated potassium channel protein 3; Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity); Belongs to the potassium channel KCNN family. KCa2.3/KCNN3 subfamily."},{"id":"ENSMUSP00000127078","abundance":0.115,"rank":16384,"name":"Gm17175","annotation":"Predicted gene 17175."},{"id":"ENSMUSP00000035351","abundance":0.115,"rank":16385,"name":"Tedc1","annotation":"Tubulin epsilon and delta complex protein 1; Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability. May play a role in counteracting perturbation of actin filaments, such as after treatment with the actin depolymerizing microbial metabolite Chivosazole F (By similarity)."},{"id":"ENSMUSP00000036755","abundance":0.114,"rank":16386,"name":"Syt15","annotation":"Synaptotagmin-15; May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues; Belongs to the synaptotagmin family."},{"id":"ENSMUSP00000026571","abundance":0.114,"rank":16387,"name":"Irf7","annotation":"Interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN- beta) and IFN-stimulated genes (ISG) by binding to an interferon- stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-depende [...] "},{"id":"ENSMUSP00000029433","abundance":0.114,"rank":16388,"name":"Ptpn22","annotation":"Tyrosine-protein phosphatase non-receptor type 22; Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (By similarity). Associates with and probably dephosphorylates CBL (By similarity). Dephosphorylates LCK at its activating 'Tyr-394' residue (By similarity). Dephosphorylates ZAP70 at its activating 'Tyr-492' residue (By similarity). Dephosphorylates the immune system activator SKAP2 (By similarity). Positively regulat [...] "},{"id":"ENSMUSP00000125267","abundance":0.114,"rank":16389,"name":"Spopfm3","annotation":"Speckle-type BTB/POZ protein family member 3."},{"id":"ENSMUSP00000074737","abundance":0.113,"rank":16390,"name":"Pitpnm3","annotation":"Membrane-associated phosphatidylinositol transfer protein 3; Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes (in vitro). Binds calcium ions (By similarity); Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily."},{"id":"ENSMUSP00000030039","abundance":0.113,"rank":16391,"name":"Fmn2","annotation":"Formin-2; Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against deg [...] "},{"id":"ENSMUSP00000146656","abundance":0.113,"rank":16392,"name":"Zfp654","annotation":"Zinc finger protein 654; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000062924","abundance":0.113,"rank":16393,"name":"Rtn4r","annotation":"Reticulon-4 receptor; Receptor for RTN4, OMG and MAG. Functions as receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition (By similarity). Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system.  [...] "},{"id":"ENSMUSP00000141449","abundance":0.113,"rank":16394,"name":"Pcdhgb2","annotation":"Protocadherin gamma subfamily B, 2."},{"id":"ENSMUSP00000149210","abundance":0.113,"rank":16395,"name":"Arfgef3","annotation":"Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells. Also regulates glucagon granule production in pancreatic alpha cells. Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (By similarity)."},{"id":"ENSMUSP00000149631","abundance":0.113,"rank":16396,"name":"Olfr1016","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000092932","abundance":0.113,"rank":16397,"name":"Trim75","annotation":"Tripartite motif-containing protein 75; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000072200","abundance":0.113,"rank":16398,"name":"Kprp","annotation":"Keratinocyte proline-rich protein."},{"id":"ENSMUSP00000075587","abundance":0.112,"rank":16399,"name":"Carmil3","annotation":"Capping protein, Arp2/3 and myosin-I linker protein 3; Belongs to the CARMIL family."},{"id":"ENSMUSP00000054804","abundance":0.112,"rank":16400,"name":"Camta1","annotation":"Calmodulin-binding transcription activator 1; Transcriptional activator; Belongs to the CAMTA family."},{"id":"ENSMUSP00000025048","abundance":0.112,"rank":16401,"name":"Acsbg3","annotation":"Acyl-CoA synthetase bubblegum family member 3."},{"id":"ENSMUSP00000064080","abundance":0.112,"rank":16402,"name":"Tmem200a","annotation":"Transmembrane protein 200A."},{"id":"ENSMUSP00000073652","abundance":0.112,"rank":16403,"name":"Ube3b","annotation":"Ubiquitin-protein ligase E3B; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates."},{"id":"ENSMUSP00000040126","abundance":0.112,"rank":16404,"name":"Kank3","annotation":"KN motif and ankyrin repeat domain-containing protein 3; May be involved in the control of cytoskeleton formation by regulating actin polymerization."},{"id":"ENSMUSP00000026886","abundance":0.112,"rank":16405,"name":"Itih5","annotation":"Inter-alpha-trypsin inhibitor heavy chain H5; May act as a tumor suppressor; Belongs to the ITIH family."},{"id":"ENSMUSP00000021356","abundance":0.111,"rank":16406,"name":"Dnaaf2","annotation":"Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. Belongs to the PIH1 family. Kintoun subfamily."},{"id":"ENSMUSP00000055267","abundance":0.111,"rank":16407,"name":"Sowahb","annotation":"Ankyrin repeat domain-containing protein SOWAHB; Belongs to the SOWAH family."},{"id":"ENSMUSP00000121753","abundance":0.111,"rank":16408,"name":"Zbtb38","annotation":"CtBP-interacting BTB zinc finger protein."},{"id":"ENSMUSP00000152709","abundance":0.111,"rank":16409,"name":"Eml5","annotation":"Echinoderm microtubule-associated protein-like 5; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family."},{"id":"ENSMUSP00000110499","abundance":0.111,"rank":16410,"name":"Uhrf1bp1","annotation":"UHRF1 (ICBP90)-binding protein 1."},{"id":"ENSMUSP00000034413","abundance":0.111,"rank":16411,"name":"Vstm5","annotation":"V-set and transmembrane domain-containing protein 5; Cell adhesion-like membrane protein of the central nervous system (CNS) which modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics. Involved in the formation of neuronal dendrites and protrusions including dendritic filopodia. In synaptogenesis, regulates synapse formation by altering dendritic spine morphology and actin distribution. Promotes formation of unstable neuronal spines such as thin and branched types. Regulates neuronal morphogenesis and migration during cortical [...] "},{"id":"ENSMUSP00000112563","abundance":0.11,"rank":16412,"name":"Poli","annotation":"DNA polymerase iota; Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template (By similarity). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (By similarity). May play a role in hypermutation of immunogobulin genes (By similarity). Forms a Schiff base wit [...] "},{"id":"ENSMUSP00000112393","abundance":0.11,"rank":16413,"name":"Itga10","annotation":"Integrin, alpha 10; Belongs to the integrin alpha chain family."},{"id":"ENSMUSP00000039943","abundance":0.11,"rank":16414,"name":"Usp38","annotation":"Ubiquitin carboxyl-terminal hydrolase 38; Deubiquitinating enzyme exhibiting a preference towards 'Lys- 63'-linked ubiquitin chains; Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000142038","abundance":0.11,"rank":16415,"name":"Tdpoz6","annotation":"TD and POZ domain-containing 6."},{"id":"ENSMUSP00000047347","abundance":0.11,"rank":16416,"name":"Prpmp5","annotation":"Proline-rich protein MP5."},{"id":"ENSMUSP00000111323","abundance":0.11,"rank":16417,"name":"Pcdha9","annotation":"Protocadherin alpha-9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain."},{"id":"ENSMUSP00000141104","abundance":0.11,"rank":16418,"name":"Mybph","annotation":"Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family."},{"id":"ENSMUSP00000053326","abundance":0.11,"rank":16419,"name":"Pcdhb19","annotation":"Protocadherin beta 19."},{"id":"ENSMUSP00000052641","abundance":0.11,"rank":16420,"name":"Zfp646","annotation":"Zinc finger protein 646; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000024931","abundance":0.109,"rank":16421,"name":"Ntn3","annotation":"Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons."},{"id":"ENSMUSP00000129238","abundance":0.109,"rank":16422,"name":"Pkdcc","annotation":"Extracellular tyrosine-protein kinase PKDCC; Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29. May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane. Probably plays a role in platelets: rapidl [...] "},{"id":"ENSMUSP00000066857","abundance":0.109,"rank":16423,"name":"Slit3","annotation":"Slit homolog 3 protein; May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors."},{"id":"ENSMUSP00000049335","abundance":0.109,"rank":16424,"name":"Ift172","annotation":"Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway."},{"id":"ENSMUSP00000094038","abundance":0.109,"rank":16425,"name":"Tex13a","annotation":"Testis-expressed 13A."},{"id":"ENSMUSP00000056147","abundance":0.109,"rank":16426,"name":"Hivep1","annotation":"Zinc finger protein 40; Transcription factor which binds specifically to the palindromic sequence 5'-GGGAAATCCC-3' in the alpha-A crystallin promoter."},{"id":"ENSMUSP00000138479","abundance":0.109,"rank":16427,"name":"Atp13a4","annotation":"Probable cation-transporting ATPase 13A4."},{"id":"ENSMUSP00000134646","abundance":0.109,"rank":16428,"name":"Ifi206","annotation":"Interferon-activated gene 206."},{"id":"ENSMUSP00000113333","abundance":0.108,"rank":16429,"name":"Kcnt2","annotation":"Potassium channel, subfamily T, member 2."},{"id":"ENSMUSP00000019405","abundance":0.108,"rank":16430,"name":"Map1s","annotation":"Microtubule-associated protein 1S; Microtubule-associated protein that mediates aggregation of mitochondria resulting in cell death and genomic destruction (MAGD). Plays a role in anchoring the microtubule organizing center to the centrosomes. Binds to DNA. Plays a role in apoptosis (By similarity). Involved in the formation of microtubule bundles; Belongs to the MAP1 family."},{"id":"ENSMUSP00000117153","abundance":0.108,"rank":16431,"name":"Itgb3bp","annotation":"Centromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand- dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF- kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis  [...] "},{"id":"ENSMUSP00000041436","abundance":0.108,"rank":16432,"name":"Slc23a4","annotation":"Solute carrier family 23 member 4."},{"id":"ENSMUSP00000142577","abundance":0.108,"rank":16433,"name":"Gm21663","annotation":"Predicted gene, 21663."},{"id":"ENSMUSP00000096477","abundance":0.107,"rank":16434,"name":"Spopfm1","annotation":"Speckle-type BTB/POZ protein family member 1."},{"id":"ENSMUSP00000140018","abundance":0.107,"rank":16435,"name":"Gm10662","annotation":"Predicted gene 10662; Belongs to the protein kinase superfamily."},{"id":"ENSMUSP00000140803","abundance":0.107,"rank":16436,"name":"Gm5891","annotation":"Predicted gene 5891."},{"id":"ENSMUSP00000146341","abundance":0.107,"rank":16437,"name":"Gm6882","annotation":"Predicted gene 6882; Belongs to the protein kinase superfamily."},{"id":"ENSMUSP00000092571","abundance":0.107,"rank":16438,"name":"Dnah7a","annotation":"Dynein, axonemal, heavy chain 7A."},{"id":"ENSMUSP00000066256","abundance":0.107,"rank":16439,"name":"Ercc6","annotation":"DNA excision repair protein ERCC-6; Essential factor involved in transcription-coupled nucleotide excision repair which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes (By similarity). Upon DNA-binding, it locally modifies DNA conformation by wrapping the DNA around itself, thereby modifying the interface between stalled RNA polymerase II and DNA (By similarity). It is required for transcription-coupled repair complex formation. It recruits the CSA complex (DCX(ERCC8) complex), nucleotide excision repair proteins and EP300 to  [...] "},{"id":"ENSMUSP00000156047","abundance":0.107,"rank":16440,"name":"Crybg3","annotation":"Beta/gamma crystallin domain-containing protein 3."},{"id":"ENSMUSP00000035203","abundance":0.107,"rank":16441,"name":"Mst1r","annotation":"Macrophage-stimulating protein receptor alpha chain; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON lea [...] "},{"id":"ENSMUSP00000138947","abundance":0.107,"rank":16442,"name":"Rhox3g","annotation":"Reproductive homeobox 3G."},{"id":"ENSMUSP00000000412","abundance":0.106,"rank":16443,"name":"Egfl6","annotation":"Epidermal growth factor-like protein 6; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly. Belongs to the nephronectin family."},{"id":"ENSMUSP00000064103","abundance":0.106,"rank":16444,"name":"Vmn1r236","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000096478","abundance":0.106,"rank":16445,"name":"Tdpoz5","annotation":"TD and POZ domain containing 5."},{"id":"ENSMUSP00000089284","abundance":0.106,"rank":16446,"name":"Tdpoz7","annotation":"TD and POZ domain-containing protein 5."},{"id":"ENSMUSP00000058362","abundance":0.106,"rank":16447,"name":"Pcdhga11","annotation":"Protocadherin gamma subfamily A, 11."},{"id":"ENSMUSP00000057938","abundance":0.106,"rank":16448,"name":"Cenpe","annotation":"Centromere-associated protein E; Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules. The transport of pole-pro [...] "},{"id":"ENSMUSP00000029548","abundance":0.105,"rank":16449,"name":"Nup210l","annotation":"Nuclear pore membrane glycoprotein 210-like."},{"id":"ENSMUSP00000060040","abundance":0.105,"rank":16450,"name":"Zfp366","annotation":"Zinc finger protein 366; Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases."},{"id":"ENSMUSP00000107773","abundance":0.105,"rank":16451,"name":"Frmpd4","annotation":"FERM and PDZ domain-containing protein 4; Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate."},{"id":"ENSMUSP00000150363","abundance":0.105,"rank":16452,"name":"Olfr1150-ps1","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000035250","abundance":0.105,"rank":16453,"name":"Alox12b","annotation":"Arachidonate 12-lipoxygenase, 12R-type; Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species. Does not convert arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega- hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to me [...] "},{"id":"ENSMUSP00000140124","abundance":0.105,"rank":16454,"name":"Pgr","annotation":"Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. Belongs to the nuclear hormone receptor family. NR3 subfamily."},{"id":"ENSMUSP00000126209","abundance":0.105,"rank":16455,"name":"Fam169a","annotation":"Soluble lamin-associated protein of 75 kDa."},{"id":"ENSMUSP00000034912","abundance":0.105,"rank":16456,"name":"Rasgrf1","annotation":"Ras-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP."},{"id":"ENSMUSP00000149118","abundance":0.105,"rank":16457,"name":"Olfr3","annotation":"Olfactory receptor 3; Odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000042057","abundance":0.105,"rank":16458,"name":"Cdcp1","annotation":"CUB domain-containing protein 1; May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis."},{"id":"ENSMUSP00000030643","abundance":0.105,"rank":16459,"name":"Extl1","annotation":"Exostosin-like 1; Probable glycosyltransferase; Belongs to the glycosyltransferase 47 family."},{"id":"ENSMUSP00000026188","abundance":0.104,"rank":16460,"name":"R3hcc1l","annotation":"Coiled-coil domain-containing protein R3HCC1L."},{"id":"ENSMUSP00000150419","abundance":0.104,"rank":16461,"name":"Olfr448","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000091419","abundance":0.104,"rank":16462,"name":"Arhgap42","annotation":"Rho GTPase-activating protein 42; May influence blood pressure by functioning as a GTPase- activating protein for RHOA in vascular smooth muscle."},{"id":"ENSMUSP00000073612","abundance":0.103,"rank":16463,"name":"Sema3e","annotation":"Semaphorin-3E; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation. Belongs to the semaphorin family."},{"id":"ENSMUSP00000052717","abundance":0.103,"rank":16464,"name":"Zbtb39","annotation":"Zinc finger and BTB domain-containing 39."},{"id":"ENSMUSP00000026703","abundance":0.103,"rank":16465,"name":"Bach1","annotation":"Transcription regulator protein BACH1; Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK. Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (By similarity); Belongs to the bZIP family. CNC subfamily."},{"id":"ENSMUSP00000040882","abundance":0.103,"rank":16466,"name":"Erich6","annotation":"Glutamate-rich protein 6; Belongs to the ERICH6 family."},{"id":"ENSMUSP00000027251","abundance":0.103,"rank":16467,"name":"Rev1","annotation":"DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family."},{"id":"ENSMUSP00000140430","abundance":0.103,"rank":16468,"name":"Dnah7c","annotation":"Dynein, axonemal, heavy chain 7C."},{"id":"ENSMUSP00000082207","abundance":0.102,"rank":16469,"name":"Tlr9","annotation":"Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in defense against systemic mouse cytomegalovirus infection. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulatio [...] "},{"id":"ENSMUSP00000017086","abundance":0.102,"rank":16470,"name":"Tmprss6","annotation":"Transmembrane protease serine 6; Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis."},{"id":"ENSMUSP00000048780","abundance":0.102,"rank":16471,"name":"Arel1","annotation":"Apoptosis-resistant E3 ubiquitin protein ligase 1; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits apoptosis by ubiquitinating and targeting for degradation a number of proapoptotic proteins including DIABLO/SMAC, HTRA2 and SEPT4/ARTS which are released from the mitochondrion into the cytosol following apoptotic stimulation."},{"id":"ENSMUSP00000033730","abundance":0.101,"rank":16472,"name":"Grpr","annotation":"Gastrin-releasing peptide receptor; Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory."},{"id":"ENSMUSP00000112472","abundance":0.101,"rank":16473,"name":"Col6a4","annotation":"Collagen alpha-4(VI) chain; Collagen VI acts as a cell-binding protein."},{"id":"ENSMUSP00000085794","abundance":0.101,"rank":16474,"name":"Pkhd1","annotation":"Polycystic kidney and hepatic disease 1."},{"id":"ENSMUSP00000147968","abundance":0.101,"rank":16475,"name":"Slc16a7","annotation":"Monocarboxylate transporter 2; Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family."},{"id":"ENSMUSP00000089758","abundance":0.101,"rank":16476,"name":"Epc2","annotation":"Enhancer of polycomb homolog 2; May play a role in transcription or DNA repair. Belongs to the enhancer of polycomb family."},{"id":"ENSMUSP00000033058","abundance":0.101,"rank":16477,"name":"Sbf2","annotation":"Myotubularin-related protein 13; Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Acts as an adapter for the phosphatase MTMR2. Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5 [...] "},{"id":"ENSMUSP00000067591","abundance":0.1,"rank":16478,"name":"Dgkk","annotation":"Diacylglycerol kinase."},{"id":"ENSMUSP00000027083","abundance":0.1,"rank":16479,"name":"Pth2r","annotation":"Parathyroid hormone 2 receptor; This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity)."},{"id":"ENSMUSP00000055815","abundance":0.1,"rank":16480,"name":"Prtg","annotation":"Protogenin; May play a role in anteroposterior axis elongation."},{"id":"ENSMUSP00000035164","abundance":0.1,"rank":16481,"name":"Topbp1","annotation":"DNA topoisomerase 2-binding protein 1; Required for DNA replication (By similarity). Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity). Induces a large increase in the kinase activity of ATR (By similarity)."},{"id":"ENSMUSP00000077697","abundance":0.1,"rank":16482,"name":"Trank1","annotation":"TPR and ankyrin repeat-containing protein 1."},{"id":"ENSMUSP00000052025","abundance":0.1,"rank":16483,"name":"H2al3","annotation":"H2A histone family member L3."},{"id":"ENSMUSP00000005352","abundance":0.099,"rank":16484,"name":"Corin","annotation":"Atrial natriuretic peptide-converting enzyme, activated protease fragment; Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB  [...] "},{"id":"ENSMUSP00000139659","abundance":0.099,"rank":16485,"name":"Gm21708","annotation":"Predicted gene, 21708."},{"id":"ENSMUSP00000097930","abundance":0.099,"rank":16486,"name":"Rbmy","annotation":"RNA-binding motif protein, Y chromosome, family 1 member A1; RNA-binding protein involved in pre-mRNA splicing. Required for sperm development. Acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Binds non-specifically to mRNAs."},{"id":"ENSMUSP00000140512","abundance":0.099,"rank":16487,"name":"Gm4064","annotation":"Predicted gene 4064."},{"id":"ENSMUSP00000139784","abundance":0.099,"rank":16488,"name":"Gm21693","annotation":"Predicted gene, 21693."},{"id":"ENSMUSP00000140936","abundance":0.099,"rank":16489,"name":"Gm10256","annotation":"Predicted gene 10256."},{"id":"ENSMUSP00000140575","abundance":0.099,"rank":16490,"name":"Gm10352","annotation":"Predicted gene 10256."},{"id":"ENSMUSP00000140704","abundance":0.099,"rank":16491,"name":"Gm21704","annotation":"Predicted gene, 21704."},{"id":"ENSMUSP00000139527","abundance":0.099,"rank":16492,"name":"Gm21677","annotation":"Predicted gene, 21677."},{"id":"ENSMUSP00000141183","abundance":0.099,"rank":16493,"name":"Gm3376","annotation":"RNA-binding motif protein, Y chromosome, family 1 member B; RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis."},{"id":"ENSMUSP00000002418","abundance":0.099,"rank":16494,"name":"Borcs8","annotation":"BLOC-1-related complex subunit 8; As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor."},{"id":"ENSMUSP00000093536","abundance":0.099,"rank":16495,"name":"Grid2","annotation":"Glutamate receptor ionotropic, delta-2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber- Purkinje cell (PF-PC) synapses through the beta-NRX1-CBLN1-GRID2 triad complex."},{"id":"ENSMUSP00000068253","abundance":0.099,"rank":16496,"name":"Gucy2g","annotation":"Guanylate cyclase 2G; Probably plays a specific functional role in the testis by binding to yet not identified ligand."},{"id":"ENSMUSP00000001583","abundance":0.099,"rank":16497,"name":"Ell2","annotation":"RNA polymerase II elongation factor ELL2; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (By similarity). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) sit [...] "},{"id":"ENSMUSP00000140150","abundance":0.099,"rank":16498,"name":"Hivep2","annotation":"Transcription factor HIVEP2; Specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, somatostatin receptor II, and interferon-beta genes. It may act in T-cell activation (By similarity)."},{"id":"ENSMUSP00000085642","abundance":0.099,"rank":16499,"name":"Iqca1l","annotation":"IQ and AAA domain-containing protein 1-like."},{"id":"ENSMUSP00000090370","abundance":0.098,"rank":16500,"name":"4930572O03Rik","annotation":"RIKEN cDNA 4930572O03 gene."},{"id":"ENSMUSP00000050144","abundance":0.098,"rank":16501,"name":"Tnfsf15","annotation":"Tumor necrosis factor ligand superfamily member 15; Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis (By similarity). Promotes splenocyte alloactivation; Belongs to the tumor necrosis factor family."},{"id":"ENSMUSP00000115246","abundance":0.098,"rank":16502,"name":"Drp2","annotation":"Dystrophin-related protein 2; Required for normal myelination and for normal organization of the cytoplasm and the formation of Cajal bands in myelinating Schwann cells. Required for normal PRX location at appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane. Possibly involved in membrane-cytoskeleton interactions of the central nervous system."},{"id":"ENSMUSP00000054797","abundance":0.098,"rank":16503,"name":"Fancm","annotation":"Fanconi anemia group M protein homolog; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. Thi [...] "},{"id":"ENSMUSP00000042405","abundance":0.098,"rank":16504,"name":"Scn7a","annotation":"Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient."},{"id":"ENSMUSP00000141396","abundance":0.098,"rank":16505,"name":"Pcdh9","annotation":"Protocadherin 9."},{"id":"ENSMUSP00000051396","abundance":0.097,"rank":16506,"name":"Palm3","annotation":"Paralemmin-3; ATP-binding protein, which may act as a adapter in the Toll- like receptor (TLR) signaling; Belongs to the paralemmin family."},{"id":"ENSMUSP00000137655","abundance":0.097,"rank":16507,"name":"Gm17078","annotation":"Predicted gene 17078."},{"id":"ENSMUSP00000125788","abundance":0.097,"rank":16508,"name":"Gm17079","annotation":"Predicted gene 17079."},{"id":"ENSMUSP00000141997","abundance":0.097,"rank":16509,"name":"Pcdhgb7","annotation":"Protocadherin gamma subfamily B, 7."},{"id":"ENSMUSP00000092553","abundance":0.097,"rank":16510,"name":"Gm10471","annotation":"Predicted gene 10471."},{"id":"ENSMUSP00000075338","abundance":0.097,"rank":16511,"name":"Tdpoz4","annotation":"TD and POZ domain-containing protein 4."},{"id":"ENSMUSP00000105752","abundance":0.097,"rank":16512,"name":"Gsdmc","annotation":"Gasdermin-C; The N-terminal moiety promotes pyroptosis and exhibits bactericidal activity. The physiological relevance of these observations is unknown; Belongs to the gasdermin family."},{"id":"ENSMUSP00000148728","abundance":0.097,"rank":16513,"name":"Iqcn","annotation":"IQ motif-containing N."},{"id":"ENSMUSP00000062795","abundance":0.096,"rank":16514,"name":"Ttll13","annotation":"Tubulin polyglutamylase TTLL13; Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step."},{"id":"ENSMUSP00000129597","abundance":0.096,"rank":16515,"name":"Tonsl","annotation":"Tonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double- strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold (By similarity). Belongs to the Tonsoku family."},{"id":"ENSMUSP00000120803","abundance":0.096,"rank":16516,"name":"Pkd1l1","annotation":"Polycystic kidney disease protein 1-like 1; Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning."},{"id":"ENSMUSP00000130718","abundance":0.095,"rank":16517,"name":"Gm1979","annotation":"Predicted gene 1979."},{"id":"ENSMUSP00000099585","abundance":0.095,"rank":16518,"name":"Trpv1","annotation":"Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits  [...] "},{"id":"ENSMUSP00000038199","abundance":0.095,"rank":16519,"name":"Fam13b","annotation":"Protein FAM13B; Belongs to the FAM13 family."},{"id":"ENSMUSP00000121275","abundance":0.095,"rank":16520,"name":"Zfp738","annotation":"Zinc finger protein 738."},{"id":"ENSMUSP00000123354","abundance":0.095,"rank":16521,"name":"Morc2b","annotation":"ATPase MORC2B; Required for chromosomal synapsis and meiotic recombination in males and females."},{"id":"ENSMUSP00000130920","abundance":0.094,"rank":16522,"name":"Gm8232","annotation":"Predicted gene 8232."},{"id":"ENSMUSP00000141299","abundance":0.093,"rank":16523,"name":"Tdpoz2","annotation":"TD and POZ domain-containing protein 2."},{"id":"ENSMUSP00000088366","abundance":0.093,"rank":16524,"name":"Gm5773","annotation":"TD and POZ domain-containing protein 2."},{"id":"ENSMUSP00000037441","abundance":0.093,"rank":16525,"name":"Atg2b","annotation":"Autophagy-related protein 2 homolog B; Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion."},{"id":"ENSMUSP00000105861","abundance":0.093,"rank":16526,"name":"Adam33","annotation":"Disintegrin and metalloproteinase domain-containing protein 33."},{"id":"ENSMUSP00000131647","abundance":0.093,"rank":16527,"name":"Rsph4a","annotation":"Radial spoke head protein 4 homolog A; Probable component of the axonemal radial spoke head (By similarity). Radial spokes are regularly spaced along cilia, sperm and flagella axonemes. They consist of a thin stalk which is attached to a subfiber of the outer doublet microtubule, and a bulbous head which is attached to the stalk and appears to interact with the projections from the central pair of microtubules."},{"id":"ENSMUSP00000076687","abundance":0.093,"rank":16528,"name":"Vmn2r73","annotation":"Vomeronasal 2, receptor 73."},{"id":"ENSMUSP00000027493","abundance":0.093,"rank":16529,"name":"Pask","annotation":"PAS domain-containing serine/threonine-protein kinase; Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in [...] "},{"id":"ENSMUSP00000101763","abundance":0.093,"rank":16530,"name":"Zranb1","annotation":"Ubiquitin thioesterase Zranb1; Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity); Belongs to the peptidase C64 family."},{"id":"ENSMUSP00000075822","abundance":0.093,"rank":16531,"name":"Usp17lb","annotation":"Ubiquitin carboxyl-terminal hydrolase 17-like protein B; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. USP17 subfamily."},{"id":"ENSMUSP00000025358","abundance":0.093,"rank":16532,"name":"Lvrn","annotation":"Aminopeptidase Q; Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo-maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met-MCA, Arg-LCA and Lys- LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C. Belongs to the peptidase M1 family."},{"id":"ENSMUSP00000150354","abundance":0.092,"rank":16533,"name":"Tyk2","annotation":"Non-receptor tyrosine-protein kinase TYK2; Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon- alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities."},{"id":"ENSMUSP00000146420","abundance":0.092,"rank":16534,"name":"Gm35339","annotation":"Predicted gene, 35339."},{"id":"ENSMUSP00000115127","abundance":0.092,"rank":16535,"name":"Sycp2l","annotation":"Synaptonemal complex protein 2-like; Oocyte-specific protein that localizes to centromeres at the dictyate stage and regulates the survival of primordial oocytes. Belongs to the SYCP2 family."},{"id":"ENSMUSP00000129703","abundance":0.092,"rank":16536,"name":"Vmn2r70","annotation":"Vomeronasal 2, receptor 70."},{"id":"ENSMUSP00000108310","abundance":0.092,"rank":16537,"name":"Hfm1","annotation":"Probable ATP-dependent DNA helicase HFM1; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis."},{"id":"ENSMUSP00000035762","abundance":0.092,"rank":16538,"name":"Spef2","annotation":"Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation."},{"id":"ENSMUSP00000071325","abundance":0.091,"rank":16539,"name":"Pcdh17","annotation":"Protocadherin 17."},{"id":"ENSMUSP00000132728","abundance":0.091,"rank":16540,"name":"Gm8229","annotation":"Predicted gene 8229."},{"id":"ENSMUSP00000104299","abundance":0.091,"rank":16541,"name":"Dnah2","annotation":"Dynein heavy chain 2, axonemal; Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity); Belongs to the dynein heavy chain family."},{"id":"ENSMUSP00000033187","abundance":0.09,"rank":16542,"name":"Cnga4","annotation":"Cyclic nucleotide-gated cation channel alpha-4; Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection."},{"id":"ENSMUSP00000095984","abundance":0.09,"rank":16543,"name":"Adamts17","annotation":"A disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 17."},{"id":"ENSMUSP00000055926","abundance":0.09,"rank":16544,"name":"Smcr8","annotation":"Guanine nucleotide exchange protein SMCR8; Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation (By similarity). The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its prot [...] "},{"id":"ENSMUSP00000102971","abundance":0.09,"rank":16545,"name":"Alpk3","annotation":"Alpha-protein kinase 3; Involved in cardiomyocyte differentiation."},{"id":"ENSMUSP00000126346","abundance":0.09,"rank":16546,"name":"Pfpl","annotation":"Pore-forming protein-like."},{"id":"ENSMUSP00000136105","abundance":0.09,"rank":16547,"name":"Zfp994","annotation":"Zinc finger protein 994."},{"id":"ENSMUSP00000055094","abundance":0.089,"rank":16548,"name":"Sh3tc2","annotation":"SH3 domain and tetratricopeptide repeat-containing protein 2."},{"id":"ENSMUSP00000039670","abundance":0.089,"rank":16549,"name":"Unkl","annotation":"Putative E3 ubiquitin-protein ligase UNKL; May participate in a protein complex showing an E3 ligase activity regulated by Rac1. Ubiquitination is directed towards itself and possibly other substrates, such as Baf60b/Smarcd2. Intrinsic E3 ligase activity has not been proven; Belongs to the unkempt family."},{"id":"ENSMUSP00000098390","abundance":0.089,"rank":16550,"name":"Abcc9","annotation":"ATP-binding cassette sub-family C member 9; Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation."},{"id":"ENSMUSP00000056682","abundance":0.089,"rank":16551,"name":"Pp2d1","annotation":"Protein phosphatase 2C-like domain-containing protein 1; Belongs to the PP2C family."},{"id":"ENSMUSP00000038450","abundance":0.088,"rank":16552,"name":"Asb16","annotation":"Ankyrin repeat and SOCS box protein 16; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins."},{"id":"ENSMUSP00000136969","abundance":0.087,"rank":16553,"name":"LOC100862043","annotation":"Protein FAM205A-2-like."},{"id":"ENSMUSP00000110899","abundance":0.087,"rank":16554,"name":"Col19a1","annotation":"Collagen alpha-1(XIX) chain; May act as a cross-bridge between fibrils and other extracellular matrix molecules. Involved in skeletal myogenesis in the developing esophagus. May play a role in organization of the pericellular matrix or the sphinteric smooth muscle."},{"id":"ENSMUSP00000049708","abundance":0.087,"rank":16555,"name":"Gpr158","annotation":"Probable G-protein coupled receptor 158; Orphan receptor; Belongs to the G-protein coupled receptor 3 family."},{"id":"ENSMUSP00000156841","abundance":0.087,"rank":16556,"name":"Prdm9","annotation":"Histone-lysine N-methyltransferase PRDM9; Histone methyltransferase that sequentially mono-, di-, and tri-methylates both 'Lys-4' (H3K4) and 'Lys-36' (H3K36) of histone H3 to produce respectively trimethylated 'Lys-4' (H3K4me3) and trimethylated 'Lys-36' (H3K36me3) histone H3 and plays a key role in meiotic prophase by determining hotspot localization thereby promoting meiotic recombination. Also can methylate all four core histones with H3 being the best substrate and the most highly modified. Is also able, on one hand, to mono and di-methylate H4K20 and on other hand to trimethylate  [...] "},{"id":"ENSMUSP00000132726","abundance":0.087,"rank":16557,"name":"Vmn2r69","annotation":"Vomeronasal 2, receptor 69."},{"id":"ENSMUSP00000143356","abundance":0.087,"rank":16558,"name":"Gm21149","annotation":"Predicted gene, 21149."},{"id":"ENSMUSP00000129907","abundance":0.087,"rank":16559,"name":"Gm6401","annotation":"Predicted gene 6401."},{"id":"ENSMUSP00000128755","abundance":0.087,"rank":16560,"name":"Gm8138","annotation":"Predicted gene 8138."},{"id":"ENSMUSP00000093679","abundance":0.087,"rank":16561,"name":"Gm8165","annotation":"Predicted gene 8165."},{"id":"ENSMUSP00000126311","abundance":0.087,"rank":16562,"name":"Gm7951","annotation":"Predicted gene 7951."},{"id":"ENSMUSP00000126820","abundance":0.086,"rank":16563,"name":"Gm8094","annotation":"Predicted gene 8094."},{"id":"ENSMUSP00000106154","abundance":0.086,"rank":16564,"name":"Slc28a2","annotation":"Sodium/nucleoside cotransporter 2; Sodium-dependent and purine-selective. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (By similarity); Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family."},{"id":"ENSMUSP00000091442","abundance":0.086,"rank":16565,"name":"Trim80","annotation":"Tripartite motif-containing 80."},{"id":"ENSMUSP00000127788","abundance":0.086,"rank":16566,"name":"Gm8127","annotation":"Predicted gene 8127."},{"id":"ENSMUSP00000080472","abundance":0.085,"rank":16567,"name":"Tdpoz3","annotation":"TD and POZ domain-containing protein 3."},{"id":"ENSMUSP00000151425","abundance":0.085,"rank":16568,"name":"4932415D10Rik","annotation":"RIKEN cDNA 4932415D10 gene."},{"id":"ENSMUSP00000029170","abundance":0.085,"rank":16569,"name":"Rbl1","annotation":"Retinoblastoma-like protein 1; Key regulator of entry into cell division (By similarity). Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F- mediated trans-activation (By simil [...] "},{"id":"ENSMUSP00000041268","abundance":0.085,"rank":16570,"name":"Cnbd2","annotation":"Cyclic nucleotide-binding domain-containing protein 2; Essential for male fertility. Plays an important role in spermatogenesis and regulates sperm motility by controlling the development of the flagellar bending of sperm."},{"id":"ENSMUSP00000061836","abundance":0.085,"rank":16571,"name":"Fat4","annotation":"Protocadherin Fat 4; Cadherins are cell-cell interaction molecules. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation."},{"id":"ENSMUSP00000026267","abundance":0.085,"rank":16572,"name":"Parp6","annotation":"Protein mono-ADP-ribosyltransferase PARP6; Mono-ADP-ribosyltransferase that mediates mono-ADP- ribosylation of target proteins."},{"id":"ENSMUSP00000131482","abundance":0.085,"rank":16573,"name":"Gm8220","annotation":"Predicted gene 8220."},{"id":"ENSMUSP00000112736","abundance":0.085,"rank":16574,"name":"Abca16","annotation":"ATP-binding cassette, sub-family A (ABC1), member 16."},{"id":"ENSMUSP00000046659","abundance":0.084,"rank":16575,"name":"Hjv","annotation":"Hemojuvelin; Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis."},{"id":"ENSMUSP00000106150","abundance":0.084,"rank":16576,"name":"Slc28a2b","annotation":"Sodium/nucleoside cotransporter; Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family."},{"id":"ENSMUSP00000127174","abundance":0.084,"rank":16577,"name":"Gm3072","annotation":"Predicted gene 3072."},{"id":"ENSMUSP00000130744","abundance":0.084,"rank":16578,"name":"Gm17654","annotation":"Predicted gene, 17654."},{"id":"ENSMUSP00000006311","abundance":0.084,"rank":16579,"name":"Tead4","annotation":"Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell [...] "},{"id":"ENSMUSP00000130823","abundance":0.083,"rank":16580,"name":"Gm8212","annotation":"Predicted gene 8212."},{"id":"ENSMUSP00000090148","abundance":0.083,"rank":16581,"name":"Vmn2r111","annotation":"Vomeronasal 2, receptor 111."},{"id":"ENSMUSP00000049063","abundance":0.083,"rank":16582,"name":"Trpc5","annotation":"Short transient receptor potential channel 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion."},{"id":"ENSMUSP00000129770","abundance":0.083,"rank":16583,"name":"Gm6482","annotation":"Predicted gene 6482."},{"id":"ENSMUSP00000130980","abundance":0.083,"rank":16584,"name":"Gm3327","annotation":"Predicted gene 3327."},{"id":"ENSMUSP00000028679","abundance":0.083,"rank":16585,"name":"Ell3","annotation":"RNA polymerase II elongation factor ELL3; Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcrip [...] "},{"id":"ENSMUSP00000039206","abundance":0.082,"rank":16586,"name":"Hace1","annotation":"E3 ubiquitin-protein ligase HACE1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defen [...] "},{"id":"ENSMUSP00000036361","abundance":0.082,"rank":16587,"name":"Eme1","annotation":"Crossover junction endonuclease EME1; Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks."},{"id":"ENSMUSP00000130604","abundance":0.082,"rank":16588,"name":"Plce1","annotation":"1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T- cell activation."},{"id":"ENSMUSP00000149986","abundance":0.082,"rank":16589,"name":"Olfr845","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000070561","abundance":0.082,"rank":16590,"name":"Tnni3k","annotation":"Serine/threonine-protein kinase TNNI3K; May play a role in cardiac physiology. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily."},{"id":"ENSMUSP00000143589","abundance":0.082,"rank":16591,"name":"Gm21190","annotation":"Predicted gene, 21190."},{"id":"ENSMUSP00000105053","abundance":0.082,"rank":16592,"name":"Arhgef28","annotation":"Rho guanine nucleotide exchange factor 28; Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis."},{"id":"ENSMUSP00000128369","abundance":0.081,"rank":16593,"name":"Gm17027","annotation":"Predicted gene 17027."},{"id":"ENSMUSP00000128216","abundance":0.081,"rank":16594,"name":"Gm7954","annotation":"Predicted gene 17027."},{"id":"ENSMUSP00000153580","abundance":0.081,"rank":16595,"name":"Gm7929","annotation":"Predicted gene 7929."},{"id":"ENSMUSP00000129043","abundance":0.081,"rank":16596,"name":"Gm8082","annotation":"Predicted gene 3015."},{"id":"ENSMUSP00000133272","abundance":0.081,"rank":16597,"name":"Gm3015","annotation":"Predicted gene 3015."},{"id":"ENSMUSP00000105555","abundance":0.081,"rank":16598,"name":"Gm14139","annotation":"Predicted gene 14139."},{"id":"ENSMUSP00000111321","abundance":0.081,"rank":16599,"name":"Pcdha11","annotation":"Protocadherin alpha 11."},{"id":"ENSMUSP00000046786","abundance":0.081,"rank":16600,"name":"Tmem183a","annotation":"Transmembrane protein 183."},{"id":"ENSMUSP00000136166","abundance":0.081,"rank":16601,"name":"Phlpp2","annotation":"PH domain leucine-rich repeat-containing protein phosphatase 2; Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apopto [...] "},{"id":"ENSMUSP00000074055","abundance":0.081,"rank":16602,"name":"Zfp772","annotation":"Zinc finger protein 772."},{"id":"ENSMUSP00000024725","abundance":0.081,"rank":16603,"name":"Efhb","annotation":"EF-hand domain-containing family member B; Cytosolic sensor for calcium, modulates the interaction of STIM1 and ORAI1 upon store depletion, the activation of store-operated Ca(2+) entry (SOCE) and NFAT translocation from cytosol to nucleus."},{"id":"ENSMUSP00000113977","abundance":0.081,"rank":16604,"name":"Cdon","annotation":"Cell adhesion molecule-related/down-regulated by oncogenes; Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3."},{"id":"ENSMUSP00000034148","abundance":0.081,"rank":16605,"name":"Il15","annotation":"Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family."},{"id":"ENSMUSP00000133641","abundance":0.081,"rank":16606,"name":"Speer4c","annotation":"Spermatogenesis-associated glutamate (E)-rich protein 4C."},{"id":"ENSMUSP00000132825","abundance":0.08,"rank":16607,"name":"Gm8247","annotation":"Predicted gene 8247."},{"id":"ENSMUSP00000124969","abundance":0.08,"rank":16608,"name":"Slc9c1","annotation":"Sodium/hydrogen exchanger 10; Sperm-specific sodium/hydrogen exchanger involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC)."},{"id":"ENSMUSP00000026580","abundance":0.08,"rank":16609,"name":"Pidd1","annotation":"P53-induced death domain-containing protein 1; Component of the DNA damage/stress response pathway that functions downstream of p53/TP53 and can either promote cell survival or apoptosis. Associated with CRADD and the CASP2 caspase, it forms the PIDDosome a complex that activates CASP2 and triggers apoptosis. Associated with IKBKG and RIPK1, it enhances sumoylation and ubiquitination of IKBKG which is important for activation of the transcription factor NF-kappa-B (By similarity)."},{"id":"ENSMUSP00000127377","abundance":0.08,"rank":16610,"name":"Gm21977","annotation":"Predicted gene 21977."},{"id":"ENSMUSP00000127822","abundance":0.08,"rank":16611,"name":"Gm8068","annotation":"Predicted gene 8068."},{"id":"ENSMUSP00000023580","abundance":0.08,"rank":16612,"name":"Usp25","annotation":"Ubiquitin carboxyl-terminal hydrolase 25; Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains (By similarity)."},{"id":"ENSMUSP00000027487","abundance":0.08,"rank":16613,"name":"Rnpepl1","annotation":"Aminopeptidase RNPEPL1; Broad specificity aminopeptidase which preferentially hydrolyzes an N-terminal methionine, citrulline or glutamine."},{"id":"ENSMUSP00000110209","abundance":0.079,"rank":16614,"name":"Tmprss7","annotation":"Transmembrane protease serine 7; Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000099349","abundance":0.079,"rank":16615,"name":"Wipi1","annotation":"WD repeat domain phosphoinositide-interacting protein 1; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Plays an important role in starvation- and calcium- mediated autophagy, as well as in mitophagy (By similarity). Functions downstream of the ULK1 and PI3-kinases that produce phosphatidylinositol 3-phosphate (PtdIns3P) on membranes of the endoplasmic reticulum once activated. Binds phosphatidylinositol 3-phosphate (PtdIns3P), and  [...] "},{"id":"ENSMUSP00000129118","abundance":0.079,"rank":16616,"name":"Gm9611","annotation":"Predicted gene 9611."},{"id":"ENSMUSP00000124348","abundance":0.079,"rank":16617,"name":"Greb1","annotation":"Protein GREB1; May play a role in estrogen-stimulated cell proliferation. Belongs to the GREB1 family."},{"id":"ENSMUSP00000094198","abundance":0.079,"rank":16618,"name":"Rhox3a2","annotation":"Reproductive homeobox on X chromosome 3."},{"id":"ENSMUSP00000110852","abundance":0.079,"rank":16619,"name":"Rhox3e","annotation":"Reproductive homeobox 3E."},{"id":"ENSMUSP00000110857","abundance":0.079,"rank":16620,"name":"Rhox3a","annotation":"Reproductive homeobox 3A."},{"id":"ENSMUSP00000110842","abundance":0.079,"rank":16621,"name":"Rhox3c","annotation":"Reproductive homeobox 3C."},{"id":"ENSMUSP00000015277","abundance":0.079,"rank":16622,"name":"Lrrk1","annotation":"Leucine-rich repeat serine/threonine-protein kinase 1."},{"id":"ENSMUSP00000132236","abundance":0.079,"rank":16623,"name":"Gm8020","annotation":"Predicted gene 8020."},{"id":"ENSMUSP00000088264","abundance":0.079,"rank":16624,"name":"Gja5","annotation":"Gap junction alpha-5 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell; Belongs to the connexin family. Alpha-type (group II) subfamily."},{"id":"ENSMUSP00000143130","abundance":0.079,"rank":16625,"name":"Gm21083","annotation":"Predicted gene, 21083."},{"id":"ENSMUSP00000058251","abundance":0.078,"rank":16626,"name":"Rnf125","annotation":"E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation."},{"id":"ENSMUSP00000022337","abundance":0.078,"rank":16627,"name":"Cdhr1","annotation":"Cadherin-related family member 1; Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells."},{"id":"ENSMUSP00000141425","abundance":0.078,"rank":16628,"name":"Dchs2","annotation":"Dachsous cadherin-related 2."},{"id":"ENSMUSP00000071508","abundance":0.077,"rank":16629,"name":"Gm10436","annotation":"Predicted gene 10436."},{"id":"ENSMUSP00000040465","abundance":0.077,"rank":16630,"name":"Abca13","annotation":"ATP-binding cassette sub-family A member 13."},{"id":"ENSMUSP00000146677","abundance":0.077,"rank":16631,"name":"Myo16","annotation":"Unconventional myosin-XVI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development (By similarity). Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis; In the C-terminal section; belongs to the NYAP family."},{"id":"ENSMUSP00000132075","abundance":0.077,"rank":16632,"name":"Gm17093","annotation":"Predicted gene 17093."},{"id":"ENSMUSP00000143029","abundance":0.076,"rank":16633,"name":"Tet2","annotation":"Methylcytosine dioxygenase TET2; Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Has a preference for 5-hydroxymethylcytosine in CpG motifs. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mam [...] "},{"id":"ENSMUSP00000130156","abundance":0.076,"rank":16634,"name":"Gm7945","annotation":"Predicted gene 7945."},{"id":"ENSMUSP00000158787","abundance":0.075,"rank":16635,"name":"Dnah14","annotation":"Dynein, axonemal, heavy chain 14."},{"id":"ENSMUSP00000027852","abundance":0.075,"rank":16636,"name":"Adcy10","annotation":"Adenylate cyclase type 10; Catalyzes the formation of the signaling molecule cAMP. May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP- responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. Involved in ciliary beat regulation (By similarity). Belongs to the adenylyl cyclase class-4/guanylyl cyclase family."},{"id":"ENSMUSP00000081497","abundance":0.075,"rank":16637,"name":"Cd163l1","annotation":"Scavenger receptor cysteine-rich type 1 protein CD163c-alpha."},{"id":"ENSMUSP00000039245","abundance":0.074,"rank":16638,"name":"Pcdh18","annotation":"Protocadherin 18; Potential calcium-dependent cell-adhesion protein."},{"id":"ENSMUSP00000043643","abundance":0.074,"rank":16639,"name":"Bahcc1","annotation":"BAH and coiled-coil domain-containing protein 1."},{"id":"ENSMUSP00000113247","abundance":0.074,"rank":16640,"name":"Uspl1","annotation":"SUMO-specific isopeptidase USPL1; SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full- length SUMO proteins to their mature forms (By similarity). Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (By similarity). Is a component of complexes that can bind to U snRNA genes (By similarity)."},{"id":"ENSMUSP00000094196","abundance":0.074,"rank":16641,"name":"Rhox3h","annotation":"Reproductive homeobox 3H."},{"id":"ENSMUSP00000043806","abundance":0.074,"rank":16642,"name":"Melk","annotation":"Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation. Required f [...] "},{"id":"ENSMUSP00000012314","abundance":0.074,"rank":16643,"name":"Zfp729a","annotation":"Zinc finger protein 729a."},{"id":"ENSMUSP00000076911","abundance":0.074,"rank":16644,"name":"Pik3c2b","annotation":"Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family."},{"id":"ENSMUSP00000094716","abundance":0.073,"rank":16645,"name":"Gm10354","annotation":"Predicted gene 10354."},{"id":"ENSMUSP00000101346","abundance":0.073,"rank":16646,"name":"Zfp982","annotation":"Zinc finger protein 982."},{"id":"ENSMUSP00000093165","abundance":0.073,"rank":16647,"name":"Oog1","annotation":"Oogenesin-1; May act as a Ras-mediated signaling protein in early embryogenesis; Belongs to the PRAME family."},{"id":"ENSMUSP00000105772","abundance":0.073,"rank":16648,"name":"Gm2042","annotation":"Predicted gene 2042."},{"id":"ENSMUSP00000091157","abundance":0.072,"rank":16649,"name":"Ano8","annotation":"Anoctamin-8; Does not exhibit calcium-activated chloride channel (CaCC) activity."},{"id":"ENSMUSP00000036503","abundance":0.072,"rank":16650,"name":"Ccdc182","annotation":"Coiled-coil domain-containing protein 182."},{"id":"ENSMUSP00000074602","abundance":0.071,"rank":16651,"name":"Vmn2r24","annotation":"Vomeronasal 2, receptor 24."},{"id":"ENSMUSP00000099365","abundance":0.071,"rank":16652,"name":"Spata32","annotation":"Spermatogenesis-associated protein 32."},{"id":"ENSMUSP00000131419","abundance":0.071,"rank":16653,"name":"Lrriq1","annotation":"Leucine-rich repeat and IQ domain-containing protein 1."},{"id":"ENSMUSP00000044913","abundance":0.07,"rank":16654,"name":"Zswim2","annotation":"E3 ubiquitin-protein ligase Zswim2; E3 ubiquitin-protein ligase involved in the regulation of Fas-, DR3- and DR4-mediated apoptosis. Functions in conjunction with the UBE2D1, UBE2D3 and UBE2E1 E2 ubiquitin-conjugating enzymes."},{"id":"ENSMUSP00000034792","abundance":0.07,"rank":16655,"name":"Ankk1","annotation":"Ankyrin repeat and protein kinase domain-containing protein 1; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family."},{"id":"ENSMUSP00000096279","abundance":0.07,"rank":16656,"name":"Ccdc33","annotation":"Coiled-coil domain-containing protein 33."},{"id":"ENSMUSP00000041377","abundance":0.07,"rank":16657,"name":"Ticrr","annotation":"Treslin; Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre- replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation (By similarity)."},{"id":"ENSMUSP00000030897","abundance":0.07,"rank":16658,"name":"Megf6","annotation":"Multiple epidermal growth factor-like domains protein 6."},{"id":"ENSMUSP00000150668","abundance":0.07,"rank":16659,"name":"Olfr679","annotation":"Olfactory receptor MOR40-2."},{"id":"ENSMUSP00000150733","abundance":0.07,"rank":16660,"name":"Olfr681","annotation":"Olfactory receptor 681."},{"id":"ENSMUSP00000028362","abundance":0.069,"rank":16661,"name":"Ly75","annotation":"Lymphocyte antigen 75; Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes (By similarity)."},{"id":"ENSMUSP00000110202","abundance":0.069,"rank":16662,"name":"Umodl1","annotation":"Uromodulin-like 1."},{"id":"ENSMUSP00000105548","abundance":0.069,"rank":16663,"name":"Gm14124","annotation":"Predicted gene 14124."},{"id":"ENSMUSP00000101383","abundance":0.068,"rank":16664,"name":"C87977","annotation":"Expressed sequence C87977."},{"id":"ENSMUSP00000104462","abundance":0.068,"rank":16665,"name":"4930438A08Rik","annotation":"Amine oxidase."},{"id":"ENSMUSP00000053412","abundance":0.068,"rank":16666,"name":"Ptprcap","annotation":"Protein tyrosine phosphatase receptor type C-associated protein."},{"id":"ENSMUSP00000032201","abundance":0.068,"rank":16667,"name":"Ret","annotation":"Extracellular cell-membrane anchored RET cadherin 120 kDa fragment; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and [...] "},{"id":"ENSMUSP00000125007","abundance":0.068,"rank":16668,"name":"Cfap43","annotation":"Cilia- and flagella-associated protein 43; Flagellar protein involved in sperm flagellum axoneme organization and function; Belongs to the CFAP43 family."},{"id":"ENSMUSP00000047705","abundance":0.068,"rank":16669,"name":"Kcnh2","annotation":"Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity)."},{"id":"ENSMUSP00000159217","abundance":0.067,"rank":16670,"name":"A930007A09Rik","annotation":"RIKEN cDNA A930007A09 gene."},{"id":"ENSMUSP00000133924","abundance":0.067,"rank":16671,"name":"Gm21671","annotation":"Predicted gene, 21671."},{"id":"ENSMUSP00000085159","abundance":0.066,"rank":16672,"name":"Prb1","annotation":"Proline-rich protein BstNI subfamily 1."},{"id":"ENSMUSP00000127976","abundance":0.066,"rank":16673,"name":"Gm17555","annotation":"Predicted gene, 17555."},{"id":"ENSMUSP00000122645","abundance":0.066,"rank":16674,"name":"Vmn2r66","annotation":"Vomeronasal 2, receptor 66."},{"id":"ENSMUSP00000126453","abundance":0.066,"rank":16675,"name":"Fam83h","annotation":"Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Belongs to the FAM83 family."},{"id":"ENSMUSP00000124804","abundance":0.066,"rank":16676,"name":"Nwd1","annotation":"NACHT domain- and WD repeat-containing protein 1; May play a role in the control of androgen receptor (AR) protein steady-state levels."},{"id":"ENSMUSP00000038871","abundance":0.066,"rank":16677,"name":"Slx4","annotation":"Structure-specific endonuclease subunit SLX4; Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1- SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts  [...] "},{"id":"ENSMUSP00000126973","abundance":0.066,"rank":16678,"name":"Vmn2r75","annotation":"Vomeronasal 2, receptor 75."},{"id":"ENSMUSP00000095710","abundance":0.065,"rank":16679,"name":"Rusc2","annotation":"Iporin."},{"id":"ENSMUSP00000062489","abundance":0.065,"rank":16680,"name":"Lrrc75a","annotation":"Leucine-rich repeat-containing protein 75A."},{"id":"ENSMUSP00000100592","abundance":0.064,"rank":16681,"name":"Rnf148","annotation":"RING finger protein 148."},{"id":"ENSMUSP00000149298","abundance":0.064,"rank":16682,"name":"Olfr354","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000046177","abundance":0.064,"rank":16683,"name":"Abcb5","annotation":"ATP-binding cassette sub-family B member 5; Drug efflux transporter present in a number of stem cells that acts as a regulator of cellular differentiation. Able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair."},{"id":"ENSMUSP00000060746","abundance":0.064,"rank":16684,"name":"Vmn1r67","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000109767","abundance":0.064,"rank":16685,"name":"Zdbf2","annotation":"DBF4-type zinc finger-containing protein 2 homolog."},{"id":"ENSMUSP00000001534","abundance":0.063,"rank":16686,"name":"Sost","annotation":"Sclerostin; Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation; Belongs to the sclerostin family."},{"id":"ENSMUSP00000140294","abundance":0.062,"rank":16687,"name":"Gm21698","annotation":"Predicted gene, 21698."},{"id":"ENSMUSP00000146381","abundance":0.062,"rank":16688,"name":"A26c2","annotation":"ANKRD26-like family C, member 2."},{"id":"ENSMUSP00000107519","abundance":0.062,"rank":16689,"name":"Ccrl2","annotation":"C-C chemokine receptor-like 2; Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine- triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptor. Plays a critical role for the development of Th2 responses (By similarity)."},{"id":"ENSMUSP00000145859","abundance":0.062,"rank":16690,"name":"Lrrc32","annotation":"Transforming growth factor beta activator LRRC32; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (By similarity). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T [...] "},{"id":"ENSMUSP00000103613","abundance":0.061,"rank":16691,"name":"Fam205a1","annotation":"Family with sequence similarity 205, member A1."},{"id":"ENSMUSP00000050825","abundance":0.061,"rank":16692,"name":"Rlf","annotation":"Rearranged L-myc fusion sequence."},{"id":"ENSMUSP00000111576","abundance":0.061,"rank":16693,"name":"Fam205a2","annotation":"Mus musculus family with sequence similarity 205, member A2 (Fam205a2), transcript variant 2, mRNA."},{"id":"ENSMUSP00000137159","abundance":0.061,"rank":16694,"name":"Fam205a3","annotation":"Family with sequence similarity 205, member A3."},{"id":"ENSMUSP00000103661","abundance":0.061,"rank":16695,"name":"Fam205a4","annotation":"Protein FAM205A-2."},{"id":"ENSMUSP00000136864","abundance":0.061,"rank":16696,"name":"Fam205a2-2","annotation":"Family with sequence similarity 205, member A2."},{"id":"ENSMUSP00000048309","abundance":0.061,"rank":16697,"name":"Stab2","annotation":"Short form stabilin-2; Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidit [...] "},{"id":"ENSMUSP00000056520","abundance":0.061,"rank":16698,"name":"Ccdc171","annotation":"Coiled-coil domain-containing protein 171."},{"id":"ENSMUSP00000048752","abundance":0.06,"rank":16699,"name":"Alpk2","annotation":"Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation. Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling (By similarity); Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily."},{"id":"ENSMUSP00000141236","abundance":0.06,"rank":16700,"name":"Slitrk3","annotation":"SLIT and NTRK-like protein 3; Suppresses neurite outgrowth."},{"id":"ENSMUSP00000124056","abundance":0.059,"rank":16701,"name":"Nbeal1","annotation":"Neurobeachin-like 1."},{"id":"ENSMUSP00000100467","abundance":0.059,"rank":16702,"name":"Olfr26","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000020449","abundance":0.059,"rank":16703,"name":"Helb","annotation":"DNA helicase B; 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'- 3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dAT [...] "},{"id":"ENSMUSP00000124251","abundance":0.059,"rank":16704,"name":"Mgat4f","annotation":"MGAT4 family, member F."},{"id":"ENSMUSP00000109502","abundance":0.059,"rank":16705,"name":"Amer1","annotation":"APC membrane recruitment protein 1; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-caten [...] "},{"id":"ENSMUSP00000137335","abundance":0.058,"rank":16706,"name":"Gm21833","annotation":"Predicted gene, 21833."},{"id":"ENSMUSP00000075025","abundance":0.058,"rank":16707,"name":"Olfr504","annotation":"Olfactory receptor Olfr504."},{"id":"ENSMUSP00000023262","abundance":0.058,"rank":16708,"name":"Gm9747","annotation":"Hypothetical secreted protein SST7."},{"id":"ENSMUSP00000098659","abundance":0.057,"rank":16709,"name":"Unc79","annotation":"Protein unc-79 homolog; Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability."},{"id":"ENSMUSP00000022508","abundance":0.057,"rank":16710,"name":"Ptpn20","annotation":"Tyrosine-protein phosphatase non-receptor type 20; Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily."},{"id":"ENSMUSP00000135960","abundance":0.057,"rank":16711,"name":"Gm21897","annotation":"Predicted gene, 21897."},{"id":"ENSMUSP00000042312","abundance":0.057,"rank":16712,"name":"Igflr1","annotation":"IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family protein IGFL."},{"id":"ENSMUSP00000043958","abundance":0.057,"rank":16713,"name":"Fam90a1b","annotation":"Family with sequence similarity 90, member A1B."},{"id":"ENSMUSP00000057556","abundance":0.057,"rank":16714,"name":"Wdfy4","annotation":"WD repeat- and FYVE domain-containing protein 4; Plays a critical role in the regulation of cDC1-mediated cross-presentation of viral and tumor antigens in dendritic cells. Mechanistically, acts near the plasma membrane and interacts with endosomal membranes to promote endosomal-to-cytosol antigen trafficking. Plays also a role in B-cell survival through regulation of autophagy."},{"id":"ENSMUSP00000137421","abundance":0.056,"rank":16715,"name":"Pol","annotation":"LINE-1 retrotransposable element ORF2 protein; Has a reverse transcriptase activity required for target- primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition. Has also an endonuclease activity that allows the introduction of nicks in the chromosomal target DNA. Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to sites of LINE-1 integration in the genome."},{"id":"ENSMUSP00000137738","abundance":0.056,"rank":16716,"name":"Nudt22","annotation":"Uridine diphosphate glucose pyrophosphatase NUDT22; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose."},{"id":"ENSMUSP00000041629","abundance":0.056,"rank":16717,"name":"Mgat4d","annotation":"Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; [Isoform 2]: May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis."},{"id":"ENSMUSP00000127303","abundance":0.056,"rank":16718,"name":"Vmn1r139","annotation":"Vomeronasal 1 receptor 139."},{"id":"ENSMUSP00000133944","abundance":0.056,"rank":16719,"name":"Vmn1r112","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000096332","abundance":0.056,"rank":16720,"name":"Vmn1r132","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000137271","abundance":0.056,"rank":16721,"name":"Vmn1r157","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000136142","abundance":0.055,"rank":16722,"name":"Vmn1r148","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000137480","abundance":0.055,"rank":16723,"name":"Vmn1r100","annotation":"Vomeronasal 1 receptor 100."},{"id":"ENSMUSP00000011315","abundance":0.055,"rank":16724,"name":"Vipr2","annotation":"Vasoactive intestinal polypeptide receptor 2; This is a receptor for VIP as well as PACAP-38 and -27, the activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Can be coupled to phospholipase C."},{"id":"ENSMUSP00000050408","abundance":0.055,"rank":16725,"name":"Cmya5","annotation":"Cardiomyopathy-associated protein 5; May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration. Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle."},{"id":"ENSMUSP00000151061","abundance":0.055,"rank":16726,"name":"Olfr902","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000094056","abundance":0.055,"rank":16727,"name":"Gm382","annotation":"Predicted gene 382."},{"id":"ENSMUSP00000020208","abundance":0.054,"rank":16728,"name":"Fgd6","annotation":"FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity)."},{"id":"ENSMUSP00000057796","abundance":0.054,"rank":16729,"name":"Adamts12","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 12; Metalloprotease that plays a role in the degradation of COMP (By similarity). Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties (By similarity)."},{"id":"ENSMUSP00000149306","abundance":0.054,"rank":16730,"name":"Slc6a16","annotation":"Solute carrier family 6, member 16."},{"id":"ENSMUSP00000071627","abundance":0.054,"rank":16731,"name":"Frem1","annotation":"FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family."},{"id":"ENSMUSP00000058588","abundance":0.054,"rank":16732,"name":"Zfp146","annotation":"Zinc finger protein OZF; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000096335","abundance":0.054,"rank":16733,"name":"Vmn1r125","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000129433","abundance":0.054,"rank":16734,"name":"Vmn1r128","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000136848","abundance":0.054,"rank":16735,"name":"Vmn1r155","annotation":"Vomeronasal 1 receptor 155."},{"id":"ENSMUSP00000136232","abundance":0.054,"rank":16736,"name":"Vmn1r107","annotation":"Vomeronasal 1 receptor 107."},{"id":"ENSMUSP00000129501","abundance":0.054,"rank":16737,"name":"Vmn1r95","annotation":"Vomeronasal 1 receptor, 95."},{"id":"ENSMUSP00000127638","abundance":0.054,"rank":16738,"name":"Vmn1r143","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000135997","abundance":0.054,"rank":16739,"name":"Vmn1r137","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000136625","abundance":0.054,"rank":16740,"name":"Vmn1r165","annotation":"Vomeronasal 1 receptor 165."},{"id":"ENSMUSP00000136091","abundance":0.054,"rank":16741,"name":"Vmn1r130","annotation":"Vomeronasal 1 receptor 130."},{"id":"ENSMUSP00000128742","abundance":0.054,"rank":16742,"name":"Vmn1r116","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000078374","abundance":0.053,"rank":16743,"name":"Zfp239","annotation":"Zinc finger protein 239; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000099887","abundance":0.053,"rank":16744,"name":"Ttc39b","annotation":"Tetratricopeptide repeat protein 39B; Regulates high density lipoprotein (HDL) cholesterol metabolism by promoting the ubiquitination and degradation of the oxysterols receptors LXR (NR1H2 and NR1H3). Belongs to the TTC39 family."},{"id":"ENSMUSP00000001792","abundance":0.053,"rank":16745,"name":"Il16","annotation":"Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA- binding subunit the GABP transcription factor complex) and HDAC3 thus maintai [...] "},{"id":"ENSMUSP00000153765","abundance":0.053,"rank":16746,"name":"Gm49394","annotation":"Predicted gene, 49394."},{"id":"ENSMUSP00000141408","abundance":0.053,"rank":16747,"name":"Pcdha4","annotation":"Protocadherin alpha-4; Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (Probable). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain."},{"id":"ENSMUSP00000108449","abundance":0.053,"rank":16748,"name":"Ankrd26","annotation":"Ankyrin repeat domain-containing protein 26; Acts as a regulator of adipogenesis. Involved in the regulation of the feeding behavior."},{"id":"ENSMUSP00000128070","abundance":0.053,"rank":16749,"name":"Kctd1","annotation":"BTB/POZ domain-containing protein KCTD1; May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent."},{"id":"ENSMUSP00000040050","abundance":0.052,"rank":16750,"name":"Odf4","annotation":"Outer dense fiber protein 4; Component of the outer dense fibers (ODF) of spermatozoa which could be involved in sperm tail structure, sperm movement and general organization of cellular cytoskeleton."},{"id":"ENSMUSP00000140600","abundance":0.052,"rank":16751,"name":"Zfy1","annotation":"Zinc finger Y-chromosomal protein 1; Probable transcriptional activator. Binds to the consensus sequence 5'-AGGCCY-3' (By similarity)."},{"id":"ENSMUSP00000055797","abundance":0.052,"rank":16752,"name":"Cnr1","annotation":"Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. Signaling typically involves reduction in cyclic AMP (By similarity). In the hypothalamus, may have a dual effect on mitochondrial respiration depending upo [...] "},{"id":"ENSMUSP00000093743","abundance":0.052,"rank":16753,"name":"Svopl","annotation":"Putative transporter SVOPL; Belongs to the major facilitator superfamily."},{"id":"ENSMUSP00000104037","abundance":0.051,"rank":16754,"name":"Efcab5","annotation":"EF-hand calcium-binding domain-containing protein 5."},{"id":"ENSMUSP00000054444","abundance":0.051,"rank":16755,"name":"Tex14","annotation":"Inactive serine/threonine-protein kinase TEX14; Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodie [...] "},{"id":"ENSMUSP00000131706","abundance":0.051,"rank":16756,"name":"Vmn1r122","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000131872","abundance":0.051,"rank":16757,"name":"Vmn1r259","annotation":"Vomeronasal 1 receptor 259."},{"id":"ENSMUSP00000100831","abundance":0.051,"rank":16758,"name":"Vmn1r248","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000100834","abundance":0.051,"rank":16759,"name":"Vmn1r127","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000030980","abundance":0.051,"rank":16760,"name":"Trmt44","annotation":"Probable tRNA (uracil-O(2)-)-methyltransferase; Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase."},{"id":"ENSMUSP00000110709","abundance":0.05,"rank":16761,"name":"Dcaf12l2","annotation":"DDB1- and CUL4-associated factor 12-like protein 2; Belongs to the WD repeat DCAF12 family."},{"id":"ENSMUSP00000038576","abundance":0.05,"rank":16762,"name":"Brca2","annotation":"Breast cancer type 2 susceptibility protein homolog; Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51- ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint acti [...] "},{"id":"ENSMUSP00000152421","abundance":0.05,"rank":16763,"name":"Ccdc85c","annotation":"Coiled-coil domain-containing protein 85C; May play a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (By similarity). May play an important role in cortical development, especially in the maintenance of radial glia."},{"id":"ENSMUSP00000082427","abundance":0.05,"rank":16764,"name":"Adam4","annotation":"A disintegrin and metallopeptidase domain 4."},{"id":"ENSMUSP00000066614","abundance":0.05,"rank":16765,"name":"Rgs7bp","annotation":"Regulator of G-protein signaling 7-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. Belongs to the RGS7BP/RGS [...] "},{"id":"ENSMUSP00000137871","abundance":0.05,"rank":16766,"name":"Dmxl1","annotation":"DmX-like protein 1."},{"id":"ENSMUSP00000040799","abundance":0.049,"rank":16767,"name":"Nhsl1","annotation":"NHS-like protein 1."},{"id":"ENSMUSP00000129810","abundance":0.049,"rank":16768,"name":"Klhl33","annotation":"Kelch-like 33."},{"id":"ENSMUSP00000148677","abundance":0.049,"rank":16769,"name":"Nlrc5","annotation":"Protein NLRC5; Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms."},{"id":"ENSMUSP00000024930","abundance":0.048,"rank":16770,"name":"Tedc2","annotation":"Tubulin epsilon and delta complex protein 2; Acts as a positive regulator of ciliary hedgehog signaling. Required for centriole stability."},{"id":"ENSMUSP00000056155","abundance":0.048,"rank":16771,"name":"Cox8c","annotation":"Cytochrome c oxidase subunit 8C, mitochondrial; Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane [...] "},{"id":"ENSMUSP00000074236","abundance":0.048,"rank":16772,"name":"T","annotation":"T-box transcription factor T; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site."},{"id":"ENSMUSP00000131534","abundance":0.047,"rank":16773,"name":"Dthd1","annotation":"Death domain-containing 1."},{"id":"ENSMUSP00000025946","abundance":0.047,"rank":16774,"name":"Cyp26a1","annotation":"Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid st [...] "},{"id":"ENSMUSP00000098051","abundance":0.046,"rank":16775,"name":"Krt26","annotation":"Keratin, type I cytoskeletal 26; Belongs to the intermediate filament family."},{"id":"ENSMUSP00000073781","abundance":0.046,"rank":16776,"name":"Gm7361","annotation":"Predicted gene 7361."},{"id":"ENSMUSP00000131925","abundance":0.046,"rank":16777,"name":"Vmn2r5","annotation":"Vomeronasal 2, receptor 5."},{"id":"ENSMUSP00000140740","abundance":0.046,"rank":16778,"name":"Dop1a","annotation":"Protein dopey-1; May be involved in protein traffic between late Golgi and early endosomes."},{"id":"ENSMUSP00000125742","abundance":0.046,"rank":16779,"name":"Cfap77","annotation":"Cilia and flagella-associated protein 77."},{"id":"ENSMUSP00000149292","abundance":0.046,"rank":16780,"name":"Olfr933","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000101480","abundance":0.045,"rank":16781,"name":"Myom3","annotation":"Myomesin-3; May link the intermediate filament cytoskeleton to the M-disk of the myofibrils in striated muscle."},{"id":"ENSMUSP00000062991","abundance":0.045,"rank":16782,"name":"Dcaf12l1","annotation":"DDB1- and CUL4-associated factor 12-like protein 1; Belongs to the WD repeat DCAF12 family."},{"id":"ENSMUSP00000154358","abundance":0.045,"rank":16783,"name":"Vmn1r196","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000051539","abundance":0.045,"rank":16784,"name":"Stpg2","annotation":"Sperm-tail PG-rich repeat-containing protein 2."},{"id":"ENSMUSP00000137189","abundance":0.044,"rank":16785,"name":"BC024978","annotation":"cDNA sequence BC024978."},{"id":"ENSMUSP00000131702","abundance":0.044,"rank":16786,"name":"Vmn1r135","annotation":"Vomeronasal 1 receptor 135."},{"id":"ENSMUSP00000130288","abundance":0.044,"rank":16787,"name":"Vmn1r163","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000114248","abundance":0.044,"rank":16788,"name":"Zfp978","annotation":"Zinc finger protein 978."},{"id":"ENSMUSP00000129173","abundance":0.044,"rank":16789,"name":"Ankrd65","annotation":"Ankyrin repeat domain 65."},{"id":"ENSMUSP00000028721","abundance":0.043,"rank":16790,"name":"Tgm5","annotation":"Protein-glutamine gamma-glutamyltransferase 5; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Contributes to the formation of the cornified cell envelope of keratinocytes (By similarity). Belongs to the transglutaminase superfamily. Transglutaminase family."},{"id":"ENSMUSP00000006341","abundance":0.043,"rank":16791,"name":"Prss16","annotation":"Thymus-specific serine protease; Protease that may play a role in T-cell development; Belongs to the peptidase S28 family."},{"id":"ENSMUSP00000057901","abundance":0.043,"rank":16792,"name":"Fbxo48","annotation":"F-box only protein 48."},{"id":"ENSMUSP00000036330","abundance":0.043,"rank":16793,"name":"Adamts20","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 20; May play a role in tissue-remodeling process occurring in both normal and pathological conditions. May have a protease- independent function in the transport from the endoplasmic reticulum to the Golgi apparatus of secretory cargos, mediated by the GON domain."},{"id":"ENSMUSP00000143887","abundance":0.043,"rank":16794,"name":"Gm38100","annotation":"Beclin-2; Involved in 2 distinct lysosomal degradation pathways: acts as a regulator of autophagy and as a regulator of G-protein coupled receptors turnover. Regulates degradation in lysosomes of a variety of G-protein coupled receptors via its interaction with GPRASP1/GASP1."},{"id":"ENSMUSP00000096800","abundance":0.042,"rank":16795,"name":"Pde7a","annotation":"High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction (By similarity)."},{"id":"ENSMUSP00000134591","abundance":0.042,"rank":16796,"name":"Cyp2j8","annotation":"Cytochrome P450, family 2, subfamily j, polypeptide 8; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000126626","abundance":0.042,"rank":16797,"name":"Gm21962","annotation":"Predicted gene, 21962."},{"id":"ENSMUSP00000154137","abundance":0.041,"rank":16798,"name":"Vmn1r217","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000050454","abundance":0.041,"rank":16799,"name":"Ush2a","annotation":"Usherin; Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the maintenance of hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport."},{"id":"ENSMUSP00000130956","abundance":0.041,"rank":16800,"name":"Smim13","annotation":"Small integral membrane protein 13."},{"id":"ENSMUSP00000135913","abundance":0.041,"rank":16801,"name":"Dcdc2b","annotation":"Doublecortin domain-containing 2b."},{"id":"ENSMUSP00000006444","abundance":0.04,"rank":16802,"name":"Tep1","annotation":"Telomerase protein component 1; Component of the telomerase ribonucleoprotein complex that is essential for the replication of chromosome termini (By similarity). Also component of the ribonucleoprotein vaults particle, a multi- subunit structure involved in nucleo-cytoplasmic transport. Responsible for the localizing and stabilizing vault RNA (vRNA) association in the vault ribonucleoprotein particle."},{"id":"ENSMUSP00000034965","abundance":0.04,"rank":16803,"name":"Snapc5","annotation":"snRNA-activating protein complex subunit 5; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box (By similarity)."},{"id":"ENSMUSP00000035444","abundance":0.04,"rank":16804,"name":"Lgr6","annotation":"Leucine-rich repeat-containing G-protein coupled receptor 6; Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal (By similarity)."},{"id":"ENSMUSP00000136370","abundance":0.039,"rank":16805,"name":"3110021N24Rik","annotation":"RIKEN cDNA 3110021N24 gene."},{"id":"ENSMUSP00000111413","abundance":0.039,"rank":16806,"name":"Ttll2","annotation":"Probable tubulin polyglutamylase TTLL2; Probable tubulin polyglutamylase that forms polyglutamate side chains on tubulin. Probably acts when complexed with other proteins; Belongs to the tubulin--tyrosine ligase family."},{"id":"ENSMUSP00000144721","abundance":0.039,"rank":16807,"name":"Wdr49","annotation":"WD repeat domain 49."},{"id":"ENSMUSP00000019986","abundance":0.039,"rank":16808,"name":"Rev3l","annotation":"DNA polymerase zeta catalytic subunit; Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function; Belongs to the DNA polymerase type-B family."},{"id":"ENSMUSP00000051211","abundance":0.039,"rank":16809,"name":"Epop","annotation":"Elongin BC and Polycomb repressive complex 2-associated protein; Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine- tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Inte [...] "},{"id":"ENSMUSP00000148416","abundance":0.039,"rank":16810,"name":"Olfr835","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000133811","abundance":0.039,"rank":16811,"name":"Cyp2j12","annotation":"Cytochrome P450, family 2, subfamily j, polypeptide 12; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000062590","abundance":0.038,"rank":16812,"name":"Phf13","annotation":"PHD finger protein 13; Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis (By similarity)."},{"id":"ENSMUSP00000026119","abundance":0.038,"rank":16813,"name":"Gcgr","annotation":"Glucagon receptor; G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signal [...] "},{"id":"ENSMUSP00000139068","abundance":0.038,"rank":16814,"name":"Olfr1162","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000100008","abundance":0.037,"rank":16815,"name":"Creb3","annotation":"Processed cyclic AMP-responsive element-binding protein 3; Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription. Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death. Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Associates with chromatin to the HERPUD1 promoter. Also induce [...] "},{"id":"ENSMUSP00000149105","abundance":0.037,"rank":16816,"name":"Olfr633","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000046412","abundance":0.037,"rank":16817,"name":"Atg2a","annotation":"Autophagy-related protein 2 homolog A; Involved in autophagosome assembly, regulating the size of nascent autophagosomes. Also regulates lipid droplets morphology and distribution within the cell; Belongs to the ATG2 family."},{"id":"ENSMUSP00000057794","abundance":0.037,"rank":16818,"name":"Adam20","annotation":"A disintegrin and metallopeptidase domain 20."},{"id":"ENSMUSP00000123025","abundance":0.037,"rank":16819,"name":"Exoc3l2","annotation":"Exocyst complex component 3-like 2."},{"id":"ENSMUSP00000159166","abundance":0.037,"rank":16820,"name":"Gm38999","annotation":"Uncharacterized protein C19orf84 homolog."},{"id":"ENSMUSP00000063743","abundance":0.037,"rank":16821,"name":"Tas2r137","annotation":"Taste receptor type 2 member 3; Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity)."},{"id":"ENSMUSP00000029520","abundance":0.036,"rank":16822,"name":"Lce1m","annotation":"Late cornified envelope 1M."},{"id":"ENSMUSP00000091964","abundance":0.036,"rank":16823,"name":"Uevld","annotation":"Ubiquitin-conjugating enzyme E2 variant 3; Possible negative regulator of polyubiquitination. In the C-terminal section; belongs to the LDH/MDH superfamily."},{"id":"ENSMUSP00000158004","abundance":0.036,"rank":16824,"name":"Vmn1r191","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000026816","abundance":0.035,"rank":16825,"name":"Wdr73","annotation":"WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics."},{"id":"ENSMUSP00000055072","abundance":0.035,"rank":16826,"name":"Pcdhb17","annotation":"Protocadherin beta 17."},{"id":"ENSMUSP00000153872","abundance":0.035,"rank":16827,"name":"Vmn1r77","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000056851","abundance":0.035,"rank":16828,"name":"Olfr735","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000150593","abundance":0.034,"rank":16829,"name":"Olfr23","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000076954","abundance":0.034,"rank":16830,"name":"Zfp61","annotation":"Zinc finger protein 61."},{"id":"ENSMUSP00000126999","abundance":0.033,"rank":16831,"name":"Bmp6","annotation":"Bone morphogenetic protein 6; Induces cartilage and bone formation; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000157606","abundance":0.033,"rank":16832,"name":"Vmn1r221","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000005255","abundance":0.033,"rank":16833,"name":"Ccn4","annotation":"CCN family member 4; Downstream regulator in the Wnt/Frizzled-signaling pathway (By similarity). Associated with cell survival. Adheres to skin and melanoma fibroblasts (By similarity). In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan (By similarity). Suppresses tumor growth in vivo."},{"id":"ENSMUSP00000077354","abundance":0.033,"rank":16834,"name":"Pou3f4","annotation":"POU domain, class 3, transcription factor 4; Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain; Belongs to the POU transcription factor family. Class-3 subfamily."},{"id":"ENSMUSP00000048722","abundance":0.033,"rank":16835,"name":"Scgb1c1","annotation":"Secretoglobin family 1C member 1."},{"id":"ENSMUSP00000009695","abundance":0.033,"rank":16836,"name":"6330409D20Rik","annotation":"RIKEN cDNA 6330409D20 gene."},{"id":"ENSMUSP00000024238","abundance":0.033,"rank":16837,"name":"Celsr3","annotation":"Cadherin EGF LAG seven-pass G-type receptor 3; Receptor that may have an important role in cell/cell signaling during nervous system formation; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily."},{"id":"ENSMUSP00000081158","abundance":0.033,"rank":16838,"name":"Zfp820","annotation":"Zinc finger protein 820."},{"id":"ENSMUSP00000148992","abundance":0.033,"rank":16839,"name":"Olfr390","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000145558","abundance":0.032,"rank":16840,"name":"Kctd14","annotation":"Potassium channel tetramerisation domain-containing 14."},{"id":"ENSMUSP00000072449","abundance":0.032,"rank":16841,"name":"Zscan5b","annotation":"Zinc finger and SCAN domain-containing 5B."},{"id":"ENSMUSP00000141054","abundance":0.032,"rank":16842,"name":"Paqr8","annotation":"Membrane progestin receptor beta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway (By similarity). May be involved in oocyte maturation. Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone (By similarity); Belongs to the ADIPOR family."},{"id":"ENSMUSP00000026693","abundance":0.032,"rank":16843,"name":"Zfp202","annotation":"Zinc finger protein 202."},{"id":"ENSMUSP00000100835","abundance":0.032,"rank":16844,"name":"Vmn1r124","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000125823","abundance":0.032,"rank":16845,"name":"Vmn1r123","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000130716","abundance":0.031,"rank":16846,"name":"Prr23a3","annotation":"Proline-rich protein 23A3; Belongs to the PRR23 family."},{"id":"ENSMUSP00000035115","abundance":0.031,"rank":16847,"name":"Vipr1","annotation":"Vasoactive intestinal polypeptide receptor 1; This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase; Belongs to the G-protein coupled receptor 2 family."},{"id":"ENSMUSP00000128692","abundance":0.031,"rank":16848,"name":"Vmn1r115","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000130557","abundance":0.031,"rank":16849,"name":"Vmn2r62","annotation":"Vomeronasal 2, receptor 62."},{"id":"ENSMUSP00000041293","abundance":0.031,"rank":16850,"name":"Asb17","annotation":"Ankyrin repeat and SOCS box protein 17; May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins."},{"id":"ENSMUSP00000141473","abundance":0.03,"rank":16851,"name":"Tigd5","annotation":"Tigger transposable element derived 5; Belongs to the tigger transposable element derived protein family."},{"id":"ENSMUSP00000060218","abundance":0.03,"rank":16852,"name":"Idnk","annotation":"Probable gluconokinase; Belongs to the gluconokinase GntK/GntV family."},{"id":"ENSMUSP00000153757","abundance":0.03,"rank":16853,"name":"Vmn1r189","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000129858","abundance":0.03,"rank":16854,"name":"Vmn1r160","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000157780","abundance":0.03,"rank":16855,"name":"Slc29a2","annotation":"Equilibrative nucleoside transporter 2; Mediates equilibrative transport of purine and pyrimidine nucleosides, and the purine base hypoxanthine; Belongs to the SLC29A/ENT transporter (TC 2.A.57) family."},{"id":"ENSMUSP00000148220","abundance":0.03,"rank":16856,"name":"Anapc10","annotation":"Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity)."},{"id":"ENSMUSP00000125817","abundance":0.03,"rank":16857,"name":"Vmn2r57","annotation":"Vomeronasal 2, receptor 57."},{"id":"ENSMUSP00000033740","abundance":0.03,"rank":16858,"name":"Zfp92","annotation":"Zinc finger protein 92; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000137580","abundance":0.03,"rank":16859,"name":"Gm4791","annotation":"Predicted gene 4791."},{"id":"ENSMUSP00000154723","abundance":0.03,"rank":16860,"name":"Olfr869","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000129444","abundance":0.03,"rank":16861,"name":"Aadacl2","annotation":"Arylacetamide deacetylase-like 2."},{"id":"ENSMUSP00000133598","abundance":0.03,"rank":16862,"name":"Vmn1r246","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000133911","abundance":0.03,"rank":16863,"name":"Vmn1r256","annotation":"Vomeronasal 1 receptor 256."},{"id":"ENSMUSP00000055178","abundance":0.03,"rank":16864,"name":"Vstm4","annotation":"V-set and transmembrane domain-containing protein 4; Peptide Lv enhances L-type voltage-gated calcium channel (L- VGCC) currents in retinal photoreceptors."},{"id":"ENSMUSP00000133350","abundance":0.03,"rank":16865,"name":"Vmn1r243","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000127126","abundance":0.03,"rank":16866,"name":"Vmn1r119","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000133608","abundance":0.03,"rank":16867,"name":"Vmn1r253","annotation":"Vomeronasal 1 receptor 253."},{"id":"ENSMUSP00000096471","abundance":0.029,"rank":16868,"name":"Gm21750","annotation":"Predicted gene, 21750."},{"id":"ENSMUSP00000022438","abundance":0.029,"rank":16869,"name":"Vmn2r88","annotation":"Vomeronasal 2, receptor 88."},{"id":"ENSMUSP00000151672","abundance":0.029,"rank":16870,"name":"Olfr93","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000041919","abundance":0.029,"rank":16871,"name":"Ttc29","annotation":"Tetratricopeptide repeat protein 29."},{"id":"ENSMUSP00000074190","abundance":0.029,"rank":16872,"name":"1700029P11Rik","annotation":"RIKEN cDNA 1700029P11 gene."},{"id":"ENSMUSP00000129089","abundance":0.029,"rank":16873,"name":"Vmn2r63","annotation":"Vomeronasal 2, receptor 63."},{"id":"ENSMUSP00000028740","abundance":0.029,"rank":16874,"name":"Ttbk2","annotation":"Tau-tubulin kinase 2; Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro."},{"id":"ENSMUSP00000034527","abundance":0.029,"rank":16875,"name":"Nxpe2","annotation":"NXPE family member 2."},{"id":"ENSMUSP00000133307","abundance":0.029,"rank":16876,"name":"Vmn1r113","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000148302","abundance":0.029,"rank":16877,"name":"Olfr868","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000041519","abundance":0.028,"rank":16878,"name":"Sct","annotation":"Secretin; Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis. Exerts its biological effects by binding to secretin receptor (SCTR), a G-protein coupled receptor expressed in the basolateral domain of several cells. Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content. Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the p [...] "},{"id":"ENSMUSP00000058111","abundance":0.028,"rank":16879,"name":"Ccnjl","annotation":"Cyclin-J-like protein; Belongs to the cyclin family. Cyclin J subfamily."},{"id":"ENSMUSP00000153997","abundance":0.028,"rank":16880,"name":"Vmn1r209","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000038630","abundance":0.028,"rank":16881,"name":"Cipc","annotation":"CLOCK-interacting pacemaker; Transcriptional repressor which may act as a negative- feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK. However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock."},{"id":"ENSMUSP00000148617","abundance":0.028,"rank":16882,"name":"Olfr857","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000100830","abundance":0.028,"rank":16883,"name":"Vmn1r249","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000128469","abundance":0.028,"rank":16884,"name":"Vmn1r129","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000129454","abundance":0.028,"rank":16885,"name":"Vmn1r260","annotation":"Vomeronasal 1 receptor 260."},{"id":"ENSMUSP00000127012","abundance":0.027,"rank":16886,"name":"Vmn1r251","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000133606","abundance":0.027,"rank":16887,"name":"Vmn1r245","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000130340","abundance":0.027,"rank":16888,"name":"Vmn1r241","annotation":"Vomeronasal 1 receptor 241."},{"id":"ENSMUSP00000131580","abundance":0.027,"rank":16889,"name":"Vmn1r117","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000134659","abundance":0.027,"rank":16890,"name":"Vmn1r255","annotation":"Vomeronasal 1 receptor 255."},{"id":"ENSMUSP00000079494","abundance":0.027,"rank":16891,"name":"Dnah9","annotation":"Dynein, axonemal, heavy chain 9."},{"id":"ENSMUSP00000035399","abundance":0.027,"rank":16892,"name":"Tmem184a","annotation":"Transmembrane protein 184A; Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells. Belongs to the TMEM184 family."},{"id":"ENSMUSP00000153892","abundance":0.027,"rank":16893,"name":"Vmn1r203","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000027629","abundance":0.027,"rank":16894,"name":"Tfcp2l1","annotation":"Transcription factor CP2-like protein 1; Transcription factor that facilitates establishment and maintenance of pluripotency in embryonic stem cells (ESCs). With Klf2, acts as the major effector of self-renewal that mediates induction of pluripotency downstream of LIF/Stat3 and Wnt/beta-catenin signaling. Required for normal duct development in the salivary gland and kidney. Coordinates the development of the kidney collecting ducts intercalated (IC) and principal (PC) cells, which regulate acid- base and salt-water homeostasis, respectively. Regulates the expression of IC genes includ [...] "},{"id":"ENSMUSP00000021005","abundance":0.027,"rank":16895,"name":"Tpo","annotation":"Thyroid peroxidase; Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4)."},{"id":"ENSMUSP00000134441","abundance":0.027,"rank":16896,"name":"Vmn2r126","annotation":"Vomeronasal 2, receptor 126."},{"id":"ENSMUSP00000021889","abundance":0.027,"rank":16897,"name":"Ctsr","annotation":"Cathepsin R."},{"id":"ENSMUSP00000022998","abundance":0.027,"rank":16898,"name":"Mtbp","annotation":"Mdm2-binding protein; May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells."},{"id":"ENSMUSP00000149344","abundance":0.026,"rank":16899,"name":"Olfr1052","annotation":"Olfactory receptor 1052; Potential odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000041061","abundance":0.026,"rank":16900,"name":"Hrh4","annotation":"Histamine H4 receptor; The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist) (By similarity); Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000137307","abundance":0.026,"rank":16901,"name":"Aadacl2fm3","annotation":"AADACL2 family member 3."},{"id":"ENSMUSP00000132789","abundance":0.026,"rank":16902,"name":"Gm5415","annotation":"Predicted gene 5415."},{"id":"ENSMUSP00000080521","abundance":0.026,"rank":16903,"name":"Zdhhc12","annotation":"Probable palmitoyltransferase ZDHHC12; Belongs to the DHHC palmitoyltransferase family."},{"id":"ENSMUSP00000137530","abundance":0.025,"rank":16904,"name":"Ppp2r3d","annotation":"Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit delta; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Interacts with retinoblastoma-related protein p107 (in vivo). May target PP2A core dimer to p107 resulting in dephosphorylation of p107."},{"id":"ENSMUSP00000153918","abundance":0.025,"rank":16905,"name":"Vmn1r199","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000154497","abundance":0.025,"rank":16906,"name":"Vmn1r18","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000054111","abundance":0.025,"rank":16907,"name":"Pcdhb14","annotation":"Protocadherin beta-14; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain."},{"id":"ENSMUSP00000095276","abundance":0.024,"rank":16908,"name":"Fbxo36","annotation":"F-box only protein 36; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000126650","abundance":0.024,"rank":16909,"name":"Vmn2r90","annotation":"Vomeronasal 2, receptor 90."},{"id":"ENSMUSP00000062279","abundance":0.024,"rank":16910,"name":"Casc1","annotation":"Protein CASC1; Belongs to the CASC1 family."},{"id":"ENSMUSP00000045925","abundance":0.024,"rank":16911,"name":"Fbxo15","annotation":"F-box only protein 15; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000132478","abundance":0.024,"rank":16912,"name":"Vmn2r79","annotation":"Vomeronasal 2, receptor 79."},{"id":"ENSMUSP00000126953","abundance":0.024,"rank":16913,"name":"Vmn2r8","annotation":"Vomeronasal 2, receptor 8."},{"id":"ENSMUSP00000131856","abundance":0.024,"rank":16914,"name":"Vmn2r59","annotation":"Vomeronasal 2, receptor 59."},{"id":"ENSMUSP00000129576","abundance":0.024,"rank":16915,"name":"Vmn2r61","annotation":"Vomeronasal 2, receptor 61."},{"id":"ENSMUSP00000020003","abundance":0.024,"rank":16916,"name":"Fam184a","annotation":"Family with sequence similarity 184, member A."},{"id":"ENSMUSP00000077615","abundance":0.024,"rank":16917,"name":"Olfr951","annotation":"Odorant receptor K4h17."},{"id":"ENSMUSP00000124528","abundance":0.024,"rank":16918,"name":"Cldn16","annotation":"Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity); Belongs to  [...] "},{"id":"ENSMUSP00000024970","abundance":0.024,"rank":16919,"name":"Gtf2a1l","annotation":"TFIIA-alpha and beta-like factor; May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription; Belongs to the TFIIA subunit 1 family."},{"id":"ENSMUSP00000127778","abundance":0.024,"rank":16920,"name":"Ttll6","annotation":"Tubulin polyglutamylase TTLL6; Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS. Belongs to the tubulin--tyrosine ligase family."},{"id":"ENSMUSP00000153823","abundance":0.024,"rank":16921,"name":"Vmn1r214","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000158706","abundance":0.024,"rank":16922,"name":"Gm2411","annotation":"Uncharacterized protein."},{"id":"ENSMUSP00000158666","abundance":0.024,"rank":16923,"name":"Cldn34c2","annotation":"Claudin 34C2."},{"id":"ENSMUSP00000108975","abundance":0.024,"rank":16924,"name":"Cldn34c1","annotation":"Claudin 34C1."},{"id":"ENSMUSP00000148832","abundance":0.024,"rank":16925,"name":"Gimd1","annotation":"GTPase IMAP family member GIMD1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily."},{"id":"ENSMUSP00000137773","abundance":0.024,"rank":16926,"name":"Gm26566","annotation":"Predicted gene, 26566."},{"id":"ENSMUSP00000112575","abundance":0.024,"rank":16927,"name":"Golga7b","annotation":"Golgin subfamily A member 7B; May be involved in protein transport from Golgi to cell surface; Belongs to the ERF4 family."},{"id":"ENSMUSP00000059770","abundance":0.023,"rank":16928,"name":"Pcdhb4","annotation":"Protocadherin beta 4."},{"id":"ENSMUSP00000129540","abundance":0.023,"rank":16929,"name":"Vmn2r77","annotation":"Vomeronasal 2, receptor 77."},{"id":"ENSMUSP00000105043","abundance":0.023,"rank":16930,"name":"R3hdml","annotation":"Peptidase inhibitor R3HDML; Putative serine protease inhibitor; Belongs to the CRISP family."},{"id":"ENSMUSP00000051278","abundance":0.023,"rank":16931,"name":"Kcnk7","annotation":"Potassium channel subfamily K member 7; Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family."},{"id":"ENSMUSP00000056148","abundance":0.023,"rank":16932,"name":"Pcdhb11","annotation":"Protocadherin beta 11."},{"id":"ENSMUSP00000126698","abundance":0.022,"rank":16933,"name":"Vmn2r78","annotation":"Vomeronasal 2, receptor 78."},{"id":"ENSMUSP00000126966","abundance":0.022,"rank":16934,"name":"Vmn2r58","annotation":"Vomeronasal 2, receptor 58."},{"id":"ENSMUSP00000031108","abundance":0.022,"rank":16935,"name":"Chrna9","annotation":"Cholinergic receptor, nicotinic, alpha polypeptide 9."},{"id":"ENSMUSP00000081520","abundance":0.022,"rank":16936,"name":"Gm11487","annotation":"Predicted gene 11487."},{"id":"ENSMUSP00000149758","abundance":0.022,"rank":16937,"name":"Olfr536","annotation":"Olfactory receptor MOR252-1."},{"id":"ENSMUSP00000106596","abundance":0.022,"rank":16938,"name":"Fam155a","annotation":"Transmembrane protein FAM155A; Belongs to the FAM155 family."},{"id":"ENSMUSP00000050357","abundance":0.022,"rank":16939,"name":"Pcdhb12","annotation":"Protocadherin beta 12."},{"id":"ENSMUSP00000035026","abundance":0.022,"rank":16940,"name":"Trim42","annotation":"Tripartite motif-containing protein 42; Belongs to the TRIM/RBCC family."},{"id":"ENSMUSP00000150128","abundance":0.021,"rank":16941,"name":"Olfr1348","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000052200","abundance":0.021,"rank":16942,"name":"Zfp260","annotation":"Zinc finger protein 260; Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator."},{"id":"ENSMUSP00000154713","abundance":0.021,"rank":16943,"name":"Vmn1r206","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000099877","abundance":0.021,"rank":16944,"name":"Cfap157","annotation":"Cilia- and flagella-associated protein 157; Specifically required during spermatogenesis for flagellum morphogenesis and sperm motility. May be required to suppress the formation of supernumerary axonemes and ensure a correct ultrastructure ; Belongs to the CFAP157 family."},{"id":"ENSMUSP00000069647","abundance":0.021,"rank":16945,"name":"Vmn2r43","annotation":"EC2-V2R pheromone receptor protein."},{"id":"ENSMUSP00000128350","abundance":0.021,"rank":16946,"name":"Vmn2r100","annotation":"Vomeronasal 2, receptor 100."},{"id":"ENSMUSP00000074421","abundance":0.021,"rank":16947,"name":"Gfral","annotation":"GDNF family receptor alpha-like; Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways. Belongs to the GDNFR family."},{"id":"ENSMUSP00000148442","abundance":0.021,"rank":16948,"name":"2900026A02Rik","annotation":"Uncharacterized protein KIAA1671."},{"id":"ENSMUSP00000129815","abundance":0.021,"rank":16949,"name":"Tarbp1","annotation":"TAR RNA-binding protein 1."},{"id":"ENSMUSP00000059457","abundance":0.021,"rank":16950,"name":"Spty2d1","annotation":"Protein SPT2 homolog; Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-fo [...] "},{"id":"ENSMUSP00000056424","abundance":0.021,"rank":16951,"name":"Pcdhb21","annotation":"Protocadherin beta 21."},{"id":"ENSMUSP00000034709","abundance":0.021,"rank":16952,"name":"Bcl2l10","annotation":"Bcl-2-like protein 10; Promotes cell survival. Suppresses apoptosis; Belongs to the Bcl-2 family."},{"id":"ENSMUSP00000126007","abundance":0.021,"rank":16953,"name":"Vmn2r67","annotation":"Vomeronasal 2, receptor 67."},{"id":"ENSMUSP00000126917","abundance":0.021,"rank":16954,"name":"Vmn2r74","annotation":"Vomeronasal 2, receptor 74."},{"id":"ENSMUSP00000083370","abundance":0.021,"rank":16955,"name":"Zfp648","annotation":"Zinc finger protein 648."},{"id":"ENSMUSP00000040885","abundance":0.021,"rank":16956,"name":"Tmem246","annotation":"Transmembrane protein 246."},{"id":"ENSMUSP00000129313","abundance":0.021,"rank":16957,"name":"Vmn2r97","annotation":"Vomeronasal 2, receptor 97."},{"id":"ENSMUSP00000131261","abundance":0.021,"rank":16958,"name":"Vmn2r98","annotation":"Vomeronasal 2, receptor 98."},{"id":"ENSMUSP00000129960","abundance":0.021,"rank":16959,"name":"Vmn2r33","annotation":"Vomeronasal 2, receptor 33."},{"id":"ENSMUSP00000097167","abundance":0.021,"rank":16960,"name":"Prmt2","annotation":"Protein arginine N-methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. May inhibit NF-kappa-B transcription, and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). Has a negative regulation effect on G1 to S transition of mitotic cell cycle. Involved in growth regulation. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. E [...] "},{"id":"ENSMUSP00000133007","abundance":0.021,"rank":16961,"name":"Vmn2r35","annotation":"Vomeronasal 2, receptor 35."},{"id":"ENSMUSP00000157931","abundance":0.021,"rank":16962,"name":"Vmn1r207","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000147537","abundance":0.021,"rank":16963,"name":"Lrrc3c","annotation":"Leucine-rich repeat-containing 3C."},{"id":"ENSMUSP00000093200","abundance":0.021,"rank":16964,"name":"Npw","annotation":"Neuropeptide W."},{"id":"ENSMUSP00000104194","abundance":0.02,"rank":16965,"name":"Vmn2r38","annotation":"Vomeronasal 2, receptor 38."},{"id":"ENSMUSP00000074613","abundance":0.02,"rank":16966,"name":"Vmn2r31","annotation":"Vomeronasal 2, receptor 31."},{"id":"ENSMUSP00000126863","abundance":0.02,"rank":16967,"name":"Vmn2r46","annotation":"Vomeronasal 2, receptor 46."},{"id":"ENSMUSP00000114699","abundance":0.02,"rank":16968,"name":"Fktn","annotation":"Fukutin; Catalyzes the transfer of CDP-ribitol to the distal N- acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N- acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate- 6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (By similarity). Required for normal location of POMGNT1 in Golgi membrane [...] "},{"id":"ENSMUSP00000134010","abundance":0.02,"rank":16969,"name":"Vmn2r39","annotation":"Vomeronasal 2, receptor 39."},{"id":"ENSMUSP00000099809","abundance":0.02,"rank":16970,"name":"March7","annotation":"E3 ubiquitin-protein ligase MARCHF7; E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). May be involved in T-cell proliferation by regulating LIF secretion. May play a role in lysosome homeostasis (By similarity)."},{"id":"ENSMUSP00000128293","abundance":0.02,"rank":16971,"name":"Vmn1r103","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000127282","abundance":0.02,"rank":16972,"name":"Vmn1r151","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000023487","abundance":0.02,"rank":16973,"name":"Arhgap31","annotation":"Rho GTPase-activating protein 31; Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration."},{"id":"ENSMUSP00000129692","abundance":0.02,"rank":16974,"name":"Vmn1r159","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000130631","abundance":0.02,"rank":16975,"name":"Vmn2r48","annotation":"Vomeronasal 2, receptor 48."},{"id":"ENSMUSP00000127309","abundance":0.02,"rank":16976,"name":"Vmn2r76","annotation":"Vomeronasal 2, receptor 76."},{"id":"ENSMUSP00000132332","abundance":0.02,"rank":16977,"name":"Vmn2r40","annotation":"Vomeronasal 2, receptor 40."},{"id":"ENSMUSP00000128337","abundance":0.02,"rank":16978,"name":"Vmn2r41","annotation":"Vomeronasal 2, receptor 41."},{"id":"ENSMUSP00000131990","abundance":0.02,"rank":16979,"name":"Vmn2r29","annotation":"Vomeronasal 2, receptor 29."},{"id":"ENSMUSP00000120802","abundance":0.02,"rank":16980,"name":"Lrrc31","annotation":"Leucine-rich repeat-containing 31."},{"id":"ENSMUSP00000035484","abundance":0.02,"rank":16981,"name":"Bank1","annotation":"B-cell scaffold protein with ankyrin repeats; Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2 (By similarity)."},{"id":"ENSMUSP00000074476","abundance":0.019,"rank":16982,"name":"Vmn2r50","annotation":"Vomeronasal 2, receptor 50."},{"id":"ENSMUSP00000158837","abundance":0.019,"rank":16983,"name":"Gm8251","annotation":"Predicted gene 8251."},{"id":"ENSMUSP00000137501","abundance":0.019,"rank":16984,"name":"Gm21822","annotation":"Predicted gene, 21822."},{"id":"ENSMUSP00000137436","abundance":0.019,"rank":16985,"name":"Gm21767","annotation":"Predicted gene, 21767."},{"id":"ENSMUSP00000056347","abundance":0.019,"rank":16986,"name":"Pcdhb16","annotation":"Protocadherin beta 16."},{"id":"ENSMUSP00000100844","abundance":0.019,"rank":16987,"name":"Vmn1r244","annotation":"Vomeronasal 1 receptor 244."},{"id":"ENSMUSP00000100822","abundance":0.019,"rank":16988,"name":"Vmn1r254","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000126410","abundance":0.019,"rank":16989,"name":"Vmn1r142","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000127861","abundance":0.019,"rank":16990,"name":"Vmn1r94","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000136646","abundance":0.019,"rank":16991,"name":"Gm21891","annotation":"Predicted gene, 21891."},{"id":"ENSMUSP00000136374","abundance":0.019,"rank":16992,"name":"Gm21725","annotation":"Predicted gene, 21725."},{"id":"ENSMUSP00000136284","abundance":0.019,"rank":16993,"name":"Gm21904","annotation":"Serine-rich secreted Y-linked protein."},{"id":"ENSMUSP00000136288","abundance":0.019,"rank":16994,"name":"Gm21866","annotation":"Predicted gene, 21866."},{"id":"ENSMUSP00000136798","abundance":0.019,"rank":16995,"name":"Gm21764","annotation":"Predicted gene, 21764."},{"id":"ENSMUSP00000136342","abundance":0.019,"rank":16996,"name":"Srsy","annotation":"Serine-rich, secreted, Y-linked."},{"id":"ENSMUSP00000136822","abundance":0.019,"rank":16997,"name":"Gm21828","annotation":"Predicted gene, 21828."},{"id":"ENSMUSP00000139845","abundance":0.019,"rank":16998,"name":"Gm3604","annotation":"Zinc finger protein."},{"id":"ENSMUSP00000128388","abundance":0.019,"rank":16999,"name":"Pdgfd","annotation":"Platelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes an [...] "},{"id":"ENSMUSP00000100837","abundance":0.019,"rank":17000,"name":"Vmn1r120","annotation":"Taste receptor type 2."},{"id":"ENSMUSP00000132337","abundance":0.019,"rank":17001,"name":"Vmn2r71","annotation":"Vomeronasal 2, receptor 71."},{"id":"ENSMUSP00000107908","abundance":0.019,"rank":17002,"name":"Zrsr2","annotation":"U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2; Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing (By similarity)."},{"id":"ENSMUSP00000131583","abundance":0.019,"rank":17003,"name":"Vmn2r101","annotation":"Vomeronasal 2, receptor 101."},{"id":"ENSMUSP00000104144","abundance":0.019,"rank":17004,"name":"Fbxo39","annotation":"F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000151843","abundance":0.018,"rank":17005,"name":"Rassf9","annotation":"Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells."},{"id":"ENSMUSP00000136989","abundance":0.018,"rank":17006,"name":"Gm21797","annotation":"Predicted gene, 21797."},{"id":"ENSMUSP00000097048","abundance":0.018,"rank":17007,"name":"Zfp808","annotation":"Zinc finger protein 808."},{"id":"ENSMUSP00000146536","abundance":0.018,"rank":17008,"name":"Gm9195","annotation":"Predicted gene 9195."},{"id":"ENSMUSP00000052089","abundance":0.018,"rank":17009,"name":"Catsperb","annotation":"Cation channel sperm-associated protein subunit beta; Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization."},{"id":"ENSMUSP00000156527","abundance":0.018,"rank":17010,"name":"Treml2","annotation":"Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation (By similarity)."},{"id":"ENSMUSP00000046883","abundance":0.018,"rank":17011,"name":"Ttl","annotation":"Tubulin--tyrosine ligase; Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin."},{"id":"ENSMUSP00000086592","abundance":0.018,"rank":17012,"name":"Agtr2","annotation":"Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation."},{"id":"ENSMUSP00000057921","abundance":0.018,"rank":17013,"name":"Pcdhb2","annotation":"Protocadherin beta 2."},{"id":"ENSMUSP00000136321","abundance":0.018,"rank":17014,"name":"Gm21800","annotation":"Predicted gene, 21800."},{"id":"ENSMUSP00000148964","abundance":0.018,"rank":17015,"name":"Olfr571","annotation":"Olfactory receptor 571."},{"id":"ENSMUSP00000138215","abundance":0.018,"rank":17016,"name":"4933405O20Rik","annotation":"Probable isocitrate dehydrogenase [NAD] gamma 2, mitochondrial; Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers."},{"id":"ENSMUSP00000094090","abundance":0.018,"rank":17017,"name":"Tmem28","annotation":"Transmembrane protein FAM155B."},{"id":"ENSMUSP00000142707","abundance":0.018,"rank":17018,"name":"Cfap47","annotation":"Cilia and flagella-associated protein 47."},{"id":"ENSMUSP00000067102","abundance":0.017,"rank":17019,"name":"Daw1","annotation":"Dynein assembly factor with WDR repeat domains 1."},{"id":"ENSMUSP00000119386","abundance":0.017,"rank":17020,"name":"Zbtb10","annotation":"Zinc finger and BTB domain-containing 10."},{"id":"ENSMUSP00000029759","abundance":0.017,"rank":17021,"name":"Mettl14","annotation":"N6-adenosine-methyltransferase non-catalytic subunit; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core (By similarity). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and proce [...] "},{"id":"ENSMUSP00000063025","abundance":0.017,"rank":17022,"name":"Serpinb6d","annotation":"Serine (or cysteine) peptidase inhibitor, clade B, member 6d; Belongs to the serpin family."},{"id":"ENSMUSP00000074670","abundance":0.017,"rank":17023,"name":"Rex1bd","annotation":"Required for excision 1-B domain-containing protein."},{"id":"ENSMUSP00000052297","abundance":0.017,"rank":17024,"name":"Chrnb3","annotation":"Neuronal acetylcholine receptor subunit beta-3; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub- subfamily."},{"id":"ENSMUSP00000070073","abundance":0.017,"rank":17025,"name":"Gm14548","annotation":"Predicted gene 14548."},{"id":"ENSMUSP00000148600","abundance":0.017,"rank":17026,"name":"Olfr160","annotation":"Olfactory receptor 151; Odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000090790","abundance":0.017,"rank":17027,"name":"Dnaaf1","annotation":"Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Plays a role in cytoplasmic preassembly of dynein arms (By similarity). Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (By similarity); Belongs to the DNAAF1 family."},{"id":"ENSMUSP00000079205","abundance":0.016,"rank":17028,"name":"Olfr954","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000137038","abundance":0.016,"rank":17029,"name":"Pcdhb20","annotation":"Protocadherin beta 20."},{"id":"ENSMUSP00000158580","abundance":0.016,"rank":17030,"name":"Tmem74bos","annotation":"Transmembrane 74B, opposite strand."},{"id":"ENSMUSP00000133259","abundance":0.016,"rank":17031,"name":"Nkapd1","annotation":"NKAP domain-containing 1."},{"id":"ENSMUSP00000152024","abundance":0.016,"rank":17032,"name":"Olfr1347","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000133726","abundance":0.016,"rank":17033,"name":"Gm20481","annotation":"Predicted gene 20481."},{"id":"ENSMUSP00000150088","abundance":0.016,"rank":17034,"name":"Olfr874","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000112708","abundance":0.016,"rank":17035,"name":"Chpt1","annotation":"Cholinephosphotransferase 1; Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes (By similarity)."},{"id":"ENSMUSP00000078084","abundance":0.016,"rank":17036,"name":"Tmem220","annotation":"Transmembrane protein 220."},{"id":"ENSMUSP00000149336","abundance":0.016,"rank":17037,"name":"Olfr157","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000148995","abundance":0.016,"rank":17038,"name":"Olfr156","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000151112","abundance":0.016,"rank":17039,"name":"Olfr847","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000133620","abundance":0.015,"rank":17040,"name":"Nkx1-1","annotation":"NK1 homeobox 1."},{"id":"ENSMUSP00000149238","abundance":0.015,"rank":17041,"name":"Olfr533","annotation":"Olfactory receptor Olfr533."},{"id":"ENSMUSP00000104255","abundance":0.015,"rank":17042,"name":"Pira2","annotation":"Paired-Ig-like receptor A2."},{"id":"ENSMUSP00000077990","abundance":0.015,"rank":17043,"name":"Olfr539","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000129055","abundance":0.015,"rank":17044,"name":"Gpr62","annotation":"G-protein coupled receptor 62; Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways. Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity)."},{"id":"ENSMUSP00000075070","abundance":0.015,"rank":17045,"name":"Calcr","annotation":"Calcitonin receptor; This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin; Belongs to the G-protein coupled receptor 2 family."},{"id":"ENSMUSP00000078022","abundance":0.015,"rank":17046,"name":"Tdrd9","annotation":"ATP-dependent RNA helicase TDRD9; ATP-binding RNA helicase which plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a n [...] "},{"id":"ENSMUSP00000066381","abundance":0.015,"rank":17047,"name":"Galr1","annotation":"Galanin receptor type 1; Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000042636","abundance":0.015,"rank":17048,"name":"Lilra6","annotation":"Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6."},{"id":"ENSMUSP00000083664","abundance":0.015,"rank":17049,"name":"Olfr18","annotation":"Olfactory receptor 18; Odorant receptor; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000146582","abundance":0.015,"rank":17050,"name":"Iqank1","annotation":"Putative IQ motif and ankyrin repeat domain-containing protein LOC642574 homolog."},{"id":"ENSMUSP00000147819","abundance":0.014,"rank":17051,"name":"Olfr61","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149340","abundance":0.014,"rank":17052,"name":"Olfr535","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000112932","abundance":0.014,"rank":17053,"name":"Ankrd24","annotation":"Ankyrin repeat domain-containing protein 24."},{"id":"ENSMUSP00000081494","abundance":0.014,"rank":17054,"name":"Olfr53","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000128815","abundance":0.014,"rank":17055,"name":"Ubap1l","annotation":"Ubiquitin-associated protein 1-like."},{"id":"ENSMUSP00000053085","abundance":0.014,"rank":17056,"name":"Lrrc75b","annotation":"Leucine-rich repeat-containing protein 75B; Belongs to the LRRC75 family."},{"id":"ENSMUSP00000123787","abundance":0.014,"rank":17057,"name":"Ankmy1","annotation":"Ankyrin repeat and MYND domain-containing protein 1."},{"id":"ENSMUSP00000060784","abundance":0.014,"rank":17058,"name":"Olfr159","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000106621","abundance":0.014,"rank":17059,"name":"Tgfbr3l","annotation":"Transforming growth factor, beta receptor III-like."},{"id":"ENSMUSP00000054407","abundance":0.014,"rank":17060,"name":"Slc5a10","annotation":"Sodium/glucose cotransporter 5; High capacity transporter for mannose and fructose and, to a lesser extent, glucose, AMG, and galactose; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family."},{"id":"ENSMUSP00000097270","abundance":0.014,"rank":17061,"name":"Fjx1","annotation":"Four-jointed box protein 1; Acts as an inhibitor of dendrite extension and branching. Belongs to the FJX1/FJ family."},{"id":"ENSMUSP00000038433","abundance":0.014,"rank":17062,"name":"Sidt1","annotation":"SID1 transmembrane family member 1; In vitro binds long double-stranded RNA (dsRNA) (500 and 700 base pairs), but not dsRNA shorter than 300 bp. Not involved in RNA autophagy, a process in which RNA is directly imported into lysosomes in an ATP-dependent manner, and degraded."},{"id":"ENSMUSP00000032093","abundance":0.014,"rank":17063,"name":"Prickle2","annotation":"Prickle-like protein 2."},{"id":"ENSMUSP00000151212","abundance":0.014,"rank":17064,"name":"Olfr118","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000044093","abundance":0.014,"rank":17065,"name":"Cyb561d2","annotation":"Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction."},{"id":"ENSMUSP00000000924","abundance":0.014,"rank":17066,"name":"Mmp11","annotation":"Stromelysin-3; May play an important role in the progression of epithelial malignancies."},{"id":"ENSMUSP00000157539","abundance":0.013,"rank":17067,"name":"Apcdd1","annotation":"Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. May act via its interaction with Wnt and LRP proteins (By similarity); Belongs to the APCDD1 family."},{"id":"ENSMUSP00000149309","abundance":0.013,"rank":17068,"name":"Olfr45","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000148238","abundance":0.013,"rank":17069,"name":"Olfr541","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000027775","abundance":0.013,"rank":17070,"name":"Efcab2","annotation":"Dynein regulatory complex protein 8; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes."},{"id":"ENSMUSP00000113266","abundance":0.013,"rank":17071,"name":"Gemin7","annotation":"Gem-associated protein 7; The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chapero [...] "},{"id":"ENSMUSP00000033991","abundance":0.013,"rank":17072,"name":"Wrn","annotation":"Werner syndrome ATP-dependent helicase homolog; Multifunctional enzyme that has both magnesium and ATP- dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks  [...] "},{"id":"ENSMUSP00000112795","abundance":0.013,"rank":17073,"name":"Klra5","annotation":"Killer cell lectin-like receptor 5; Receptor on natural killer (NK) cells for class I MHC."},{"id":"ENSMUSP00000022356","abundance":0.013,"rank":17074,"name":"Usp54","annotation":"Inactive ubiquitin carboxyl-terminal hydrolase 54; Has no peptidase activity; Belongs to the peptidase C19 family."},{"id":"ENSMUSP00000133865","abundance":0.013,"rank":17075,"name":"Olfr121","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000150099","abundance":0.013,"rank":17076,"name":"Olfr119","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000077628","abundance":0.013,"rank":17077,"name":"Sec22c","annotation":"Vesicle-trafficking protein SEC22c; May be involved in vesicle transport between the ER and the Golgi complex; Belongs to the synaptobrevin family."},{"id":"ENSMUSP00000039758","abundance":0.012,"rank":17078,"name":"B4galnt4","annotation":"N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans; Belongs to the chondroitin N- acetylgalactosaminyltransferase family."},{"id":"ENSMUSP00000076569","abundance":0.012,"rank":17079,"name":"Olfr850","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000064900","abundance":0.012,"rank":17080,"name":"Sec31b","annotation":"Protein transport protein Sec31B; As a component of the coat protein complex II (COPII), may function in vesicle budding and cargo export from the endoplasmic reticulum."},{"id":"ENSMUSP00000150947","abundance":0.012,"rank":17081,"name":"Ccdc82","annotation":"Coiled-coil domain-containing protein 82."},{"id":"ENSMUSP00000096238","abundance":0.012,"rank":17082,"name":"Zfp974","annotation":"Zinc finger protein 974."},{"id":"ENSMUSP00000131004","abundance":0.012,"rank":17083,"name":"Cby3","annotation":"Protein chibby homolog 3."},{"id":"ENSMUSP00000087713","abundance":0.012,"rank":17084,"name":"Sgms2","annotation":"Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signa [...] "},{"id":"ENSMUSP00000150503","abundance":0.012,"rank":17085,"name":"Olfr1346","annotation":"Olfactory receptor MOR103-6."},{"id":"ENSMUSP00000073105","abundance":0.012,"rank":17086,"name":"Cyp26c1","annotation":"Cytochrome P450, family 26, subfamily c, polypeptide 1; Belongs to the cytochrome P450 family."},{"id":"ENSMUSP00000073038","abundance":0.012,"rank":17087,"name":"Zfp760","annotation":"Zinc finger protein 760."},{"id":"ENSMUSP00000110192","abundance":0.012,"rank":17088,"name":"Lrrc61","annotation":"Leucine-rich repeat-containing protein 61."},{"id":"ENSMUSP00000148486","abundance":0.012,"rank":17089,"name":"Capn15","annotation":"Calpain-15; Belongs to the peptidase C2 family."},{"id":"ENSMUSP00000043570","abundance":0.012,"rank":17090,"name":"Dsel","annotation":"Dermatan-sulfate epimerase-like protein."},{"id":"ENSMUSP00000099313","abundance":0.012,"rank":17091,"name":"Cep295nl","annotation":"CEP295 N-terminal-like protein."},{"id":"ENSMUSP00000064462","abundance":0.012,"rank":17092,"name":"Calhm5","annotation":"Calcium homeostasis modulator protein 5; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family."},{"id":"ENSMUSP00000153384","abundance":0.012,"rank":17093,"name":"Cc2d2b","annotation":"Coiled-coil and C2 domain-containing 2B."},{"id":"ENSMUSP00000077606","abundance":0.012,"rank":17094,"name":"Dyrk4","annotation":"Dual specificity tyrosine-phosphorylation-regulated kinase 4; Possible non-essential role in spermiogenesis."},{"id":"ENSMUSP00000149371","abundance":0.012,"rank":17095,"name":"Olfr985","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000130888","abundance":0.011,"rank":17096,"name":"Pwwp2b","annotation":"PWWP domain-containing 2B."},{"id":"ENSMUSP00000022100","abundance":0.011,"rank":17097,"name":"Slc6a3","annotation":"Sodium-dependent dopamine transporter; Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily."},{"id":"ENSMUSP00000113291","abundance":0.011,"rank":17098,"name":"Ankrd60","annotation":"Ankyrin repeat domain 60."},{"id":"ENSMUSP00000158544","abundance":0.011,"rank":17099,"name":"Ubash3a","annotation":"Ubiquitin-associated and SH3 domain-containing protein A; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain (By similarity). Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation."},{"id":"ENSMUSP00000129520","abundance":0.011,"rank":17100,"name":"Vmn2r9","annotation":"Vomeronasal 2, receptor 9."},{"id":"ENSMUSP00000028329","abundance":0.011,"rank":17101,"name":"Sapcd2","annotation":"Suppressor APC domain-containing protein 2; Plays a role in planar mitotic spindle orientation in retinal progenitor cells (RPCs) and promotes the production of symmetric terminal divisions. Negatively regulates the mitotic apical cortex localization of GPSM2 (By similarity). Involved also in positive regulation of cell proliferation and tumor cell growth (By similarity)."},{"id":"ENSMUSP00000058676","abundance":0.011,"rank":17102,"name":"Pramef8","annotation":"4732496O08Rik protein."},{"id":"ENSMUSP00000125502","abundance":0.011,"rank":17103,"name":"Rad52","annotation":"DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity); Belongs to the RAD52 family."},{"id":"ENSMUSP00000019931","abundance":0.011,"rank":17104,"name":"Lrp11","annotation":"Low-density lipoprotein receptor-related protein 11."},{"id":"ENSMUSP00000128333","abundance":0.011,"rank":17105,"name":"Vmn2r15","annotation":"Vomeronasal 2, receptor 15."},{"id":"ENSMUSP00000133821","abundance":0.011,"rank":17106,"name":"Zfp57","annotation":"Zinc finger protein 57; Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZFP57 plays the predominant role in imprinting maintenance. In contrast, in humans, ZNF445 seems to be the major factor early embryonic imprint [...] "},{"id":"ENSMUSP00000103492","abundance":0.011,"rank":17107,"name":"Olfr155","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000126596","abundance":0.011,"rank":17108,"name":"Vmn2r86","annotation":"Vomeronasal 2, receptor 86."},{"id":"ENSMUSP00000113964","abundance":0.01,"rank":17109,"name":"Lrit1","annotation":"Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1; Possible role in phototransduction."},{"id":"ENSMUSP00000077563","abundance":0.01,"rank":17110,"name":"Kcnh1","annotation":"Potassium voltage-gated channel subfamily H member 1; Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel. Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity)."},{"id":"ENSMUSP00000105255","abundance":0.01,"rank":17111,"name":"Cbx6","annotation":"Chromobox protein homolog 6; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (By similarity). Recruitment to chromatin might occur in [...] "},{"id":"ENSMUSP00000145470","abundance":0.01,"rank":17112,"name":"Rnf224","annotation":"RING finger protein 224."},{"id":"ENSMUSP00000034720","abundance":0.01,"rank":17113,"name":"Polr2m","annotation":"DNA-directed RNA polymerase II subunit GRINL1A; Isoform 1 appears to be stable component of the Pol II(G) complex form of RNA polymerase II. Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in Mediator-dependent regulation of transcription activation. Isoform 1 acts in vitro as negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equival [...] "},{"id":"ENSMUSP00000092079","abundance":0.01,"rank":17114,"name":"Vmn2r84","annotation":"Vomeronasal 2, receptor 84."},{"id":"ENSMUSP00000007584","abundance":0.01,"rank":17115,"name":"Pcdhac1","annotation":"Protocadherin alpha subfamily C, 1."},{"id":"ENSMUSP00000001965","abundance":0.01,"rank":17116,"name":"Kcnh6","annotation":"Potassium Voltage-gated channel, subfamily H (Eag-related), member 6."},{"id":"ENSMUSP00000045200","abundance":0.01,"rank":17117,"name":"Neil2","annotation":"Endonuclease 8-like 2; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5- hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with [...] "},{"id":"ENSMUSP00000136605","abundance":0.01,"rank":17118,"name":"Gm3286","annotation":"PRAME family member 8."},{"id":"ENSMUSP00000071174","abundance":0.01,"rank":17119,"name":"E330014E10Rik","annotation":"RIKEN cDNA E330014E10 gene."},{"id":"ENSMUSP00000144419","abundance":0.01,"rank":17120,"name":"Gm3286-2","annotation":"Predicted gene 3286."},{"id":"ENSMUSP00000143927","abundance":0.01,"rank":17121,"name":"D5Ertd577e","annotation":"DNA segment, Chr 5, ERATO Doi 577,-expressed."},{"id":"ENSMUSP00000087318","abundance":0.01,"rank":17122,"name":"Mcc","annotation":"Mutated in colorectal cancers."},{"id":"ENSMUSP00000113221","abundance":0.01,"rank":17123,"name":"Matk","annotation":"Megakaryocyte-associated tyrosine-protein kinase; Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC- family members in brain by specifically phosphorylating their C- terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T- cell proliferation."},{"id":"ENSMUSP00000025000","abundance":0.01,"rank":17124,"name":"St6gal2","annotation":"Beta-galactoside alpha-2,6-sialyltransferase 2; Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6- sialyltransferase activity toward oligosaccharides that have the Gal- beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids."},{"id":"ENSMUSP00000139909","abundance":0.01,"rank":17125,"name":"Prkag3","annotation":"5'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a  [...] "},{"id":"ENSMUSP00000106205","abundance":0.01,"rank":17126,"name":"LOC108168681","annotation":"Predicted gene 6509."},{"id":"ENSMUSP00000128792","abundance":0.01,"rank":17127,"name":"Vmn2r85","annotation":"Vomeronasal 2, receptor 85."},{"id":"ENSMUSP00000143807","abundance":0.01,"rank":17128,"name":"N4bp2","annotation":"NEDD4-binding protein 2."},{"id":"ENSMUSP00000136930","abundance":0.01,"rank":17129,"name":"ENSMUSP00000136930","annotation":"annotation not available"},{"id":"ENSMUSP00000129296","abundance":0.01,"rank":17130,"name":"Vmn2r120","annotation":"Vomeronasal 2, receptor 120."},{"id":"ENSMUSP00000132865","abundance":0.01,"rank":17131,"name":"Lrrc10b","annotation":"Leucine-rich repeat-containing 10B."},{"id":"ENSMUSP00000110711","abundance":0.01,"rank":17132,"name":"Tenm1","annotation":"Teneurin C-terminal-associated peptide; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). [Ten-1 intracellular domain]: Induces gene transcription activation; Belongs to the tenascin family. Teneurin subfamily."},{"id":"ENSMUSP00000086984","abundance":0.009,"rank":17133,"name":"Cma2","annotation":"Mast cell protease 10; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000128015","abundance":0.009,"rank":17134,"name":"Vmn2r14","annotation":"Vomeronasal 2, receptor 14."},{"id":"ENSMUSP00000133218","abundance":0.009,"rank":17135,"name":"Vmn2r11","annotation":"Vomeronasal 2, receptor 11."},{"id":"ENSMUSP00000034378","abundance":0.009,"rank":17136,"name":"Slc7a6","annotation":"Y+L amino acid transporter 2; Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigme [...] "},{"id":"ENSMUSP00000025803","abundance":0.009,"rank":17137,"name":"Dkk1","annotation":"Dickkopf-related protein 1; Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning ; Belongs to the dickkopf family."},{"id":"ENSMUSP00000093476","abundance":0.009,"rank":17138,"name":"Mcpt9","annotation":"Mast cell protease 9."},{"id":"ENSMUSP00000019572","abundance":0.009,"rank":17139,"name":"Zfp874b","annotation":"Regulator of sex-limitation candidate 16."},{"id":"ENSMUSP00000071782","abundance":0.009,"rank":17140,"name":"Rhox8","annotation":"Reproductive homeobox 8."},{"id":"ENSMUSP00000153860","abundance":0.009,"rank":17141,"name":"Vmn1r66","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000129215","abundance":0.009,"rank":17142,"name":"Vmn2r87","annotation":"Vomeronasal 2, receptor 87."},{"id":"ENSMUSP00000154644","abundance":0.009,"rank":17143,"name":"Vmn1r184","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000036731","abundance":0.009,"rank":17144,"name":"Atf7ip2","annotation":"Activating transcription factor 7-interacting protein 2; Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (By similarity); Belongs to the MCAF family."},{"id":"ENSMUSP00000032261","abundance":0.009,"rank":17145,"name":"Clec12b","annotation":"C-type lectin domain family 12 member B; Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases (By similarity)."},{"id":"ENSMUSP00000035663","abundance":0.009,"rank":17146,"name":"Capsl","annotation":"Calcyphosin-like protein."},{"id":"ENSMUSP00000094365","abundance":0.009,"rank":17147,"name":"Mroh9","annotation":"Maestro heat-like repeat family member 9."},{"id":"ENSMUSP00000158910","abundance":0.009,"rank":17148,"name":"Olfr560","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000026408","abundance":0.009,"rank":17149,"name":"Gdf11","annotation":"Growth/differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3."},{"id":"ENSMUSP00000121903","abundance":0.009,"rank":17150,"name":"Lrrc37a","annotation":"Leucine-rich repeat-containing 37A."},{"id":"ENSMUSP00000019660","abundance":0.008,"rank":17151,"name":"Zkscan1","annotation":"Zinc finger protein with KRAB and SCAN domains 1; May be involved in transcriptional regulation."},{"id":"ENSMUSP00000154816","abundance":0.008,"rank":17152,"name":"Vmn1r185","annotation":"Vomeronasal type-1 receptor."},{"id":"ENSMUSP00000136208","abundance":0.008,"rank":17153,"name":"LOC624931","annotation":"Predicted gene 6351."},{"id":"ENSMUSP00000144247","abundance":0.008,"rank":17154,"name":"Gm7682","annotation":"Predicted gene 7682."},{"id":"ENSMUSP00000137612","abundance":0.008,"rank":17155,"name":"LOC102634529","annotation":"Predicted gene 7682."},{"id":"ENSMUSP00000114696","abundance":0.008,"rank":17156,"name":"Gm7982","annotation":"Predicted gene 6351."},{"id":"ENSMUSP00000119594","abundance":0.008,"rank":17157,"name":"Gm6351","annotation":"Predicted gene 6351."},{"id":"ENSMUSP00000030949","abundance":0.008,"rank":17158,"name":"Tas1r3","annotation":"Taste receptor type 1 member 3; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D-enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses."},{"id":"ENSMUSP00000056691","abundance":0.008,"rank":17159,"name":"C87499","annotation":"Expressed sequence C87499."},{"id":"ENSMUSP00000147162","abundance":0.008,"rank":17160,"name":"Gm19410","annotation":"Predicted gene, 19410."},{"id":"ENSMUSP00000002100","abundance":0.008,"rank":17161,"name":"Tmem25","annotation":"Transmembrane protein 25; In neurons, modulates the degradation of NMDA receptor GRIN2B subunit. Plays a role in the regulation of neuronal excitability."},{"id":"ENSMUSP00000136558","abundance":0.008,"rank":17162,"name":"LOC620551","annotation":"PRAME family member 8-like."},{"id":"ENSMUSP00000056610","abundance":0.008,"rank":17163,"name":"Zfp689","annotation":"Zinc finger protein 689; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family."},{"id":"ENSMUSP00000151399","abundance":0.008,"rank":17164,"name":"Olfr746","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000106756","abundance":0.008,"rank":17165,"name":"D430041D05Rik","annotation":"RIKEN cDNA D430041D05 gene."},{"id":"ENSMUSP00000137276","abundance":0.008,"rank":17166,"name":"LOC620639","annotation":"Uncharacterized LOC620639."},{"id":"ENSMUSP00000083215","abundance":0.008,"rank":17167,"name":"Gm6502","annotation":"Predicted gene 6502."},{"id":"ENSMUSP00000144354","abundance":0.008,"rank":17168,"name":"Gm6509","annotation":"Predicted gene 6509."},{"id":"ENSMUSP00000001559","abundance":0.008,"rank":17169,"name":"Itfg2","annotation":"KICSTOR complex protein ITFG2; As part of the KICSTOR complex functions in the amino acid- sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose."},{"id":"ENSMUSP00000016026","abundance":0.008,"rank":17170,"name":"Lcorl","annotation":"Ligand-dependent nuclear receptor corepressor-like protein; May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3'. May play a role in spermatogenesis."},{"id":"ENSMUSP00000025729","abundance":0.007,"rank":17171,"name":"Tnks2","annotation":"Poly [ADP-ribose] polymerase tankyrase-2; Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly- ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta- catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediate [...] "},{"id":"ENSMUSP00000050128","abundance":0.007,"rank":17172,"name":"2310057M21Rik","annotation":"ATPase PAAT; ATPase that regulates mitochondrial ABC transporters ABCB7, ABCB8/MITOSUR and ABCB10. Regulates mitochondrial ferric concentration and heme biosynthesis and plays a role in the maintenance of mitochondrial homeostasis and cell survival."},{"id":"ENSMUSP00000037561","abundance":0.007,"rank":17173,"name":"Slc19a2","annotation":"Thiamine transporter 1; High-affinity transporter for the intake of thiamine. Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family."},{"id":"ENSMUSP00000103178","abundance":0.007,"rank":17174,"name":"Zkscan16","annotation":"Zinc finger with KRAB and SCAN domains 16."},{"id":"ENSMUSP00000130969","abundance":0.007,"rank":17175,"name":"Gpr137","annotation":"Integral membrane protein GPR137; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. May play a role in autophagy."},{"id":"ENSMUSP00000139697","abundance":0.007,"rank":17176,"name":"Gm28961","annotation":"Predicted gene 28961."},{"id":"ENSMUSP00000113680","abundance":0.007,"rank":17177,"name":"Fam189a1","annotation":"Protein FAM189A1; Belongs to the FAM189 family."},{"id":"ENSMUSP00000155164","abundance":0.007,"rank":17178,"name":"Sec14l5","annotation":"SEC14-like 5 (S. cerevisiae)."},{"id":"ENSMUSP00000149508","abundance":0.007,"rank":17179,"name":"Cxcr5","annotation":"C-X-C chemokine receptor type 5; Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes."},{"id":"ENSMUSP00000126862","abundance":0.007,"rank":17180,"name":"Zfp595","annotation":"Regulator of sex-limitation candidate 23."},{"id":"ENSMUSP00000075658","abundance":0.007,"rank":17181,"name":"Arhgap10","annotation":"Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death."},{"id":"ENSMUSP00000060318","abundance":0.007,"rank":17182,"name":"Fam205c","annotation":"Protein FAM205C."},{"id":"ENSMUSP00000128200","abundance":0.007,"rank":17183,"name":"Spata31d1d","annotation":"Spermatogenesis-associated 31 subfamily D, member 1D."},{"id":"ENSMUSP00000022235","abundance":0.007,"rank":17184,"name":"Htr1a","annotation":"5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second  [...] "},{"id":"ENSMUSP00000147930","abundance":0.007,"rank":17185,"name":"Gm4869","annotation":"Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family."},{"id":"ENSMUSP00000151529","abundance":0.007,"rank":17186,"name":"Misp","annotation":"Mitotic interactor and substrate of PLK1; Plays a role in mitotic spindle orientation and mitotic progression. Regulates the distribution of dynactin at the cell cortex in a PLK1-dependent manner, thus stabilizing cortical and astral microtubule attachments required for proper mitotic spindle positioning. May link microtubules to the actin cytoskeleton and focal adhesions. May be required for directed cell migration and centrosome orientation. May also be necessary for proper stacking of the Golgi apparatus (By similarity); Belongs to the MISP family."},{"id":"ENSMUSP00000007046","abundance":0.007,"rank":17187,"name":"Tmco6","annotation":"Transmembrane and coiled-coil domain-containing protein 6."},{"id":"ENSMUSP00000041427","abundance":0.006,"rank":17188,"name":"Lefty1","annotation":"Left-right determination factor 1; Required for left-right axis determination as a regulator of LEFTY2 and NODAL; Belongs to the TGF-beta family."},{"id":"ENSMUSP00000065571","abundance":0.006,"rank":17189,"name":"Rtkn","annotation":"Rhotekin; Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures (By similarity)."},{"id":"ENSMUSP00000152883","abundance":0.006,"rank":17190,"name":"Macc1","annotation":"Metastasis-associated in colon cancer 1."},{"id":"ENSMUSP00000025010","abundance":0.006,"rank":17191,"name":"Tmem8","annotation":"Post-GPI attachment to proteins factor 6; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchor proteins (GPI-AP). Has phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI. Required for the shedding of the GPI-AP TDGF1, but not CFC1, at the cell surface. Shedding of TDGF1 modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells. Also indirectly involved in the tr [...] "},{"id":"ENSMUSP00000045468","abundance":0.006,"rank":17192,"name":"Ift122","annotation":"Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (By similarity). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia."},{"id":"ENSMUSP00000053643","abundance":0.006,"rank":17193,"name":"Zfp282","annotation":"Zinc finger protein 282."},{"id":"ENSMUSP00000027533","abundance":0.006,"rank":17194,"name":"Klhl30","annotation":"Kelch-like protein 30."},{"id":"ENSMUSP00000152537","abundance":0.006,"rank":17195,"name":"Pim2","annotation":"Serine/threonine-protein kinase pim-2; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro- apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly t [...] "},{"id":"ENSMUSP00000120588","abundance":0.006,"rank":17196,"name":"Crocc2","annotation":"Ciliary rootlet coiled-coil, rootletin family member 2."},{"id":"ENSMUSP00000100061","abundance":0.005,"rank":17197,"name":"4930452B06Rik","annotation":"Uncharacterized protein C3orf67 homolog."},{"id":"ENSMUSP00000018002","abundance":0.005,"rank":17198,"name":"Ift52","annotation":"Intraflagellar transport protein 52 homolog; Involved in ciliogenesis as part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. Required for the anterograde transport of IFT88 (By similarity)."},{"id":"ENSMUSP00000142907","abundance":0.005,"rank":17199,"name":"Bmp3","annotation":"Bone morphogenetic protein 3; Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification."},{"id":"ENSMUSP00000139502","abundance":0.005,"rank":17200,"name":"Gm28372","annotation":"Predicted gene 28372."},{"id":"ENSMUSP00000019987","abundance":0.005,"rank":17201,"name":"Traf3ip2","annotation":"cDNA fis, clone TRACH2006870,moderately similar to Homo sapiens adaptor protein CIKS mRNA."},{"id":"ENSMUSP00000108783","abundance":0.005,"rank":17202,"name":"Zbtb34","annotation":"Zinc finger and BTB domain-containing 34."},{"id":"ENSMUSP00000042466","abundance":0.005,"rank":17203,"name":"Calhm4","annotation":"Calcium homeostasis modulator protein 4; Pore-forming subunit of a voltage-gated ion channel. Belongs to the CALHM family."},{"id":"ENSMUSP00000071815","abundance":0.005,"rank":17204,"name":"Dmtf1","annotation":"Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53- dependent growth arrest. May also cooperate with MYB to activate transcription of the ANPEP gene. Binds to the consensus sequence 5'- CCCG[GT]ATGT-3'. Belongs to the DMTF1 family."},{"id":"ENSMUSP00000031691","abundance":0.005,"rank":17205,"name":"Hyal4","annotation":"Hyaluronidase-4; Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide (By similarity)."},{"id":"ENSMUSP00000026173","abundance":0.005,"rank":17206,"name":"Wdr45b","annotation":"WD repeat domain phosphoinositide-interacting protein 3; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Binds phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases and is recruited at phagophore assembly sites where it regulates the elongation of nascent phagophores downstream of WIPI2. In the cellular response to starvation, may also functi [...] "},{"id":"ENSMUSP00000142455","abundance":0.005,"rank":17207,"name":"Rimbp2","annotation":"RIMS-binding protein 2; Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B."},{"id":"ENSMUSP00000046924","abundance":0.005,"rank":17208,"name":"Slc18a1","annotation":"Chromaffin granule amine transporter; Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells."},{"id":"ENSMUSP00000087643","abundance":0.005,"rank":17209,"name":"Sema3g","annotation":"Semaphorin-3G; Has chemorepulsive activities for sympathetic axons. Ligand of NRP2."},{"id":"ENSMUSP00000001253","abundance":0.005,"rank":17210,"name":"Slc26a4","annotation":"Pendrin; Sodium-independent transporter of chloride and iodide."},{"id":"ENSMUSP00000109239","abundance":0.005,"rank":17211,"name":"Dmrtc1b","annotation":"Doublesex and mab-3 related transcription factor 8.2 isoform c."},{"id":"ENSMUSP00000097296","abundance":0.005,"rank":17212,"name":"Nxpe3","annotation":"Neurexophilin and PC-esterase domain family, member 3."},{"id":"ENSMUSP00000026858","abundance":0.005,"rank":17213,"name":"Plk4","annotation":"Serine/threonine-protein kinase PLK4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit  [...] "},{"id":"ENSMUSP00000027488","abundance":0.005,"rank":17214,"name":"Capn10","annotation":"Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity)."},{"id":"ENSMUSP00000027056","abundance":0.005,"rank":17215,"name":"Prex2","annotation":"Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5- trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase (By similarity)."},{"id":"ENSMUSP00000046286","abundance":0.005,"rank":17216,"name":"Slc51a","annotation":"Organic solute transporter subunit alpha; Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids."},{"id":"ENSMUSP00000029686","abundance":0.004,"rank":17217,"name":"Hcn3","annotation":"Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3; Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. Belongs to the potassium channel HCN family."},{"id":"ENSMUSP00000054546","abundance":0.004,"rank":17218,"name":"Rhbdl2","annotation":"Rhomboid-related protein 2, C-terminal fragment; Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity); Belongs to the peptidase S54 family."},{"id":"ENSMUSP00000081398","abundance":0.004,"rank":17219,"name":"Kif19a","annotation":"Kinesin-like protein KIF19; Plus end-directed microtubule-dependent motor protein that regulates the length of motile cilia by mediating depolymerization of microtubules at ciliary tips; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family."},{"id":"ENSMUSP00000064465","abundance":0.004,"rank":17220,"name":"Espl1","annotation":"Separin; Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms (By similarity)."},{"id":"ENSMUSP00000053595","abundance":0.004,"rank":17221,"name":"Kcnk12","annotation":"Potassium channel, subfamily K, member 12; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family."},{"id":"ENSMUSP00000039804","abundance":0.004,"rank":17222,"name":"Cpz","annotation":"Carboxypeptidase Z; Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing (By similarity); Belongs to the peptidase M14 family."},{"id":"ENSMUSP00000050246","abundance":0.004,"rank":17223,"name":"Xxylt1","annotation":"Xyloside xylosyltransferase 1; Alpha-1,3-xylosyltransferase, which elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats in the extracellular domain of target proteins by catalyzing the addition of the second xylose. Known targets include Notch proteins and coagulation factors, such as F9."},{"id":"ENSMUSP00000071863","abundance":0.004,"rank":17224,"name":"Cfap57","annotation":"Cilia- and flagella-associated protein 57."},{"id":"ENSMUSP00000091301","abundance":0.004,"rank":17225,"name":"Rassf1","annotation":"Ras association domain-containing protein 1; Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by [...] "},{"id":"ENSMUSP00000131127","abundance":0.004,"rank":17226,"name":"Tmem191c","annotation":"Transmembrane protein 191C; Belongs to the TMEM191 family."},{"id":"ENSMUSP00000139420","abundance":0.004,"rank":17227,"name":"Flacc1","annotation":"Flagellum-associated coiled-coil domain-containing protein 1."},{"id":"ENSMUSP00000156868","abundance":0.004,"rank":17228,"name":"Gm7356","annotation":"Predicted gene 7356."},{"id":"ENSMUSP00000079460","abundance":0.004,"rank":17229,"name":"Fbxw22","annotation":"F-box and WD-40 domain protein 22."},{"id":"ENSMUSP00000108202","abundance":0.004,"rank":17230,"name":"Nckap5","annotation":"NCK-associated protein 5."},{"id":"ENSMUSP00000117421","abundance":0.004,"rank":17231,"name":"A830018L16Rik","annotation":"Uncharacterized protein C8orf34 homolog."},{"id":"ENSMUSP00000159139","abundance":0.004,"rank":17232,"name":"Shld3","annotation":"Shieldin complex subunit 3; Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres."},{"id":"ENSMUSP00000140965","abundance":0.004,"rank":17233,"name":"Gm7358","annotation":"Predicted gene 7358."},{"id":"ENSMUSP00000020220","abundance":0.004,"rank":17234,"name":"Nuak1","annotation":"NUAK family SNF1-like kinase 1; Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP [...] "},{"id":"ENSMUSP00000023270","abundance":0.003,"rank":17235,"name":"Cep97","annotation":"Centrosomal protein of 97 kDa; Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome (By similarity)."},{"id":"ENSMUSP00000107670","abundance":0.003,"rank":17236,"name":"Fbxw28","annotation":"F-box and WD-40 domain protein 28."},{"id":"ENSMUSP00000143404","abundance":0.003,"rank":17237,"name":"Fbxw14","annotation":"F-box and WD-40 domain protein 14."},{"id":"ENSMUSP00000094997","abundance":0.003,"rank":17238,"name":"Gm7168","annotation":"Sperm motility kinase Y; May play a role in sperm motility, especially in the regulation of flagellar function; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Smok subfamily."},{"id":"ENSMUSP00000005825","abundance":0.003,"rank":17239,"name":"Pan2","annotation":"PAN2-PAN3 deadenylation complex catalytic subunit Pan2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent  [...] "},{"id":"ENSMUSP00000075898","abundance":0.003,"rank":17240,"name":"Ccdc36","annotation":"Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance."},{"id":"ENSMUSP00000129765","abundance":0.003,"rank":17241,"name":"Parp10","annotation":"Protein mono-ADP-ribosyltransferase PARP10; ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA."},{"id":"ENSMUSP00000040310","abundance":0.003,"rank":17242,"name":"Inha","annotation":"Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Inhibin deficient mice are viable but are acutely sensitive to [...] "},{"id":"ENSMUSP00000043078","abundance":0.003,"rank":17243,"name":"Hoxd1","annotation":"Homeobox protein Hox-D1; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures."},{"id":"ENSMUSP00000091917","abundance":0.003,"rank":17244,"name":"Tmem116","annotation":"Transmembrane protein 116."},{"id":"ENSMUSP00000075918","abundance":0.003,"rank":17245,"name":"Fbxw19","annotation":"F-box and WD-40 domain protein 19."},{"id":"ENSMUSP00000127475","abundance":0.003,"rank":17246,"name":"Mapk1ip1l","annotation":"MAPK-interacting and spindle-stabilizing protein-like; Belongs to the MISS family."},{"id":"ENSMUSP00000040522","abundance":0.003,"rank":17247,"name":"Slc16a8","annotation":"Monocarboxylate transporter 3; Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity)."},{"id":"ENSMUSP00000152770","abundance":0.003,"rank":17248,"name":"Kif28","annotation":"Kinesin-like protein KIF28P; Microtubule-dependent motor protein required for mitochondrion morhology and transport of mitochondria in neuronal cells; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family."},{"id":"ENSMUSP00000023219","abundance":0.002,"rank":17249,"name":"Fbxl6","annotation":"F-box/LRR-repeat protein 6; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex."},{"id":"ENSMUSP00000014647","abundance":0.002,"rank":17250,"name":"Pkd2l2","annotation":"Polycystic kidney disease 2-like 2 protein; May function as a subunit of a cation channel and play a role in fertilization."},{"id":"ENSMUSP00000136090","abundance":0.002,"rank":17251,"name":"7530416G11Rik","annotation":"RIKEN cDNA 7530416G11 gene."},{"id":"ENSMUSP00000124751","abundance":0.002,"rank":17252,"name":"4930558K02Rik","annotation":"RIKEN cDNA 4930558K02 gene."},{"id":"ENSMUSP00000021323","abundance":0.002,"rank":17253,"name":"Efcab15","annotation":"EF-hand calcium-binding domain 15."},{"id":"ENSMUSP00000092277","abundance":0.002,"rank":17254,"name":"B3gnt8","annotation":"UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8; Beta-1,3-N-acetylglucosaminyltransferase that plays a role in the elongation of specific branch structures of multiantennary N- glycans. Has strong activity towards tetraantennary N-glycans and 2,6 triantennary glycans (By similarity); Belongs to the glycosyltransferase 31 family."},{"id":"ENSMUSP00000003762","abundance":0.002,"rank":17255,"name":"Has1","annotation":"Hyaluronan synthase 1; Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito- oligosaccharide depending on the substrate."},{"id":"ENSMUSP00000067939","abundance":0.002,"rank":17256,"name":"Srsf12","annotation":"Serine/arginine-rich splicing factor 12; Splicing factor that seems to antagonize SR proteins in pre- mRNA splicing regulation."},{"id":"ENSMUSP00000039035","abundance":0.002,"rank":17257,"name":"Ankrd12","annotation":"Ankyrin repeat domain 12."},{"id":"ENSMUSP00000036029","abundance":0.002,"rank":17258,"name":"Clca2","annotation":"Calcium-activated chloride channel regulator 2; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4; Belongs to the CLCR family."},{"id":"ENSMUSP00000031899","abundance":0.002,"rank":17259,"name":"Kel","annotation":"Kell blood group glycoprotein homolog; Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3 (By similarity); Belongs to the peptidase M13 family."},{"id":"ENSMUSP00000129216","abundance":0.002,"rank":17260,"name":"Agbl2","annotation":"Cytosolic carboxypeptidase 2; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin."},{"id":"ENSMUSP00000087394","abundance":0.002,"rank":17261,"name":"Slc44a5","annotation":"Choline transporter-like protein 5."},{"id":"ENSMUSP00000149872","abundance":0.002,"rank":17262,"name":"Olfr792","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000144716","abundance":0.002,"rank":17263,"name":"Olfr798","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000022953","abundance":0.002,"rank":17264,"name":"Fam135b","annotation":"Protein FAM135B; Belongs to the FAM135 family."},{"id":"ENSMUSP00000000221","abundance":0.002,"rank":17265,"name":"Scnn1g","annotation":"Amiloride-sensitive sodium channel subunit gamma; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensi [...] "},{"id":"ENSMUSP00000091381","abundance":0.002,"rank":17266,"name":"Grin3a","annotation":"Glutamate receptor ionotropic, NMDA3A."},{"id":"ENSMUSP00000150273","abundance":0.002,"rank":17267,"name":"Inafm2","annotation":"InaF motif-containing 2."},{"id":"ENSMUSP00000072743","abundance":0.002,"rank":17268,"name":"Olfr773","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000148854","abundance":0.002,"rank":17269,"name":"Olfr772","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000081819","abundance":0.002,"rank":17270,"name":"Nlrp14","annotation":"NACHT, LRR and PYD domains-containing protein 14; May be involved in inflammation and spermatogenesis. Belongs to the NLRP family."},{"id":"ENSMUSP00000092408","abundance":0.002,"rank":17271,"name":"Cited4","annotation":"Cbp/p300-interacting transactivator 4; Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. Belongs to the CITED family."},{"id":"ENSMUSP00000105245","abundance":0.002,"rank":17272,"name":"Cbx7","annotation":"Chromobox protein homolog 7; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3) (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). Trimethyl [...] "},{"id":"ENSMUSP00000145040","abundance":0.002,"rank":17273,"name":"Olfr785","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000149729","abundance":0.001,"rank":17274,"name":"Gm4894","annotation":"Predicted gene, EG235327."},{"id":"ENSMUSP00000127563","abundance":0.001,"rank":17275,"name":"Tmem207","annotation":"Transmembrane protein 207."},{"id":"ENSMUSP00000134368","abundance":0.001,"rank":17276,"name":"Isx","annotation":"Intestine-specific homeobox; Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by regulating BCO1 expression in the intestine."},{"id":"ENSMUSP00000021065","abundance":0.001,"rank":17277,"name":"Cacng1","annotation":"Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily."},{"id":"ENSMUSP00000110526","abundance":0.001,"rank":17278,"name":"Mbnl3","annotation":"Muscleblind-like protein 3; Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins (By similarity). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction."},{"id":"ENSMUSP00000044938","abundance":0.001,"rank":17279,"name":"Mitf","annotation":"Microphthalmia-associated transcription factor; Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocyt [...] "},{"id":"ENSMUSP00000030677","abundance":0.001,"rank":17280,"name":"Map3k6","annotation":"Mitogen-activated protein kinase kinase kinase 6; Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways."},{"id":"ENSMUSP00000137298","abundance":0.001,"rank":17281,"name":"Tdrd5","annotation":"Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. Belongs to the TDRD5 family."},{"id":"ENSMUSP00000075224","abundance":0.001,"rank":17282,"name":"Jag2","annotation":"Protein jagged-2; Putative Notch ligand involved in the mediation of Notch signaling. Plays an essential role during limb, craniofacial and thymic development. May be involved in myogenesis and in the development of peripheral and central nervous systems."},{"id":"ENSMUSP00000024704","abundance":0.001,"rank":17283,"name":"Flywch2","annotation":"FLYWCH family member 2."},{"id":"ENSMUSP00000151812","abundance":0.001,"rank":17284,"name":"Gm867","annotation":"Predicted gene 867."},{"id":"ENSMUSP00000090443","abundance":0.0009,"rank":17285,"name":"Dlx3","annotation":"Homeobox protein DLX-3; Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis; Belongs to the distal-less homeobox family."},{"id":"ENSMUSP00000070741","abundance":0.0009,"rank":17286,"name":"Ddx60","annotation":"DEAD (Asp-Glu-Ala-Asp) box polypeptide 60."},{"id":"ENSMUSP00000150990","abundance":0.0009,"rank":17287,"name":"Olfr322","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000150027","abundance":0.0008,"rank":17288,"name":"Olfr317","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000031749","abundance":0.0008,"rank":17289,"name":"Nobox","annotation":"Homeobox protein NOBOX; Transcription factor which plays an essential role in postnatal follicle development. Binds preferentially to the DNA sequences 5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3'. Directly regulates the transcription of POU5F1 and GDF9 during early folliculogenesis."},{"id":"ENSMUSP00000087069","abundance":0.0008,"rank":17290,"name":"Tlx2","annotation":"T-cell leukemia homeobox protein 2; Transcription activator that binds DNA elements with the consensus sequence 5'-CGGTAATTGG-3'. Binds DNA via its homeobox. Required for normal cell death of enteric neurons in the gastrointestinal tract. Required for normal development of the enteric nervous system, and for proper development of normal motility of the gastrointestinal tract."},{"id":"ENSMUSP00000158821","abundance":0.0008,"rank":17291,"name":"Lhb-2","annotation":"Lutropin subunit beta."},{"id":"ENSMUSP00000022708","abundance":0.0008,"rank":17292,"name":"Trim52","annotation":"Tripartite motif-containing 52."},{"id":"ENSMUSP00000051158","abundance":0.0008,"rank":17293,"name":"Meox1","annotation":"Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independen [...] "},{"id":"ENSMUSP00000153498","abundance":0.0008,"rank":17294,"name":"Gm47995","annotation":"Predicted gene, 47995."},{"id":"ENSMUSP00000006632","abundance":0.0008,"rank":17295,"name":"Zdhhc24","annotation":"Probable palmitoyltransferase ZDHHC24."},{"id":"ENSMUSP00000148108","abundance":0.0008,"rank":17296,"name":"Gm11634","annotation":"Predicted gene 11634."},{"id":"ENSMUSP00000153233","abundance":0.0007,"rank":17297,"name":"Gm8947","annotation":"Predicted gene 8947."},{"id":"ENSMUSP00000052166","abundance":0.0007,"rank":17298,"name":"Prr3","annotation":"Proline-rich protein 3."},{"id":"ENSMUSP00000051280","abundance":0.0007,"rank":17299,"name":"Olfr544","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000021066","abundance":0.0007,"rank":17300,"name":"Cacng4","annotation":"Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization."},{"id":"ENSMUSP00000153442","abundance":0.0007,"rank":17301,"name":"3110040M04Rik","annotation":"RIKEN cDNA 3110040M04 gene."},{"id":"ENSMUSP00000153493","abundance":0.0007,"rank":17302,"name":"Gm47996","annotation":"Predicted gene, 47996."},{"id":"ENSMUSP00000129972","abundance":0.0007,"rank":17303,"name":"C5ar1","annotation":"C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production."},{"id":"ENSMUSP00000126191","abundance":0.0006,"rank":17304,"name":"Mchr1","annotation":"Melanin-concentrating hormone receptor 1; Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis."},{"id":"ENSMUSP00000150824","abundance":0.0006,"rank":17305,"name":"Olfr668","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000148919","abundance":0.0006,"rank":17306,"name":"Olfr666","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000137666","abundance":0.0006,"rank":17307,"name":"Jsrp1","annotation":"Junctional sarcoplasmic reticulum protein 1; Involved in skeletal muscle excitation/contraction coupling (EC), probably acting as a regulator of the voltage-sensitive calcium channel CACNA1S (By similarity). EC is a physiological process whereby an electrical signal (depolarization of the plasma membrane) is converted into a chemical signal, a calcium gradient, by the opening of ryanodine receptor calcium release channels. May regulate CACNA1S membrane targeting and activity."},{"id":"ENSMUSP00000129376","abundance":0.0006,"rank":17308,"name":"Olfr564","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000154348","abundance":0.0006,"rank":17309,"name":"Olfr607","annotation":"Olfactory receptor."},{"id":"ENSMUSP00000152996","abundance":0.0006,"rank":17310,"name":"Gm47985","annotation":"Predicted gene, 47985."},{"id":"ENSMUSP00000037503","abundance":0.0006,"rank":17311,"name":"Rep15","annotation":"Rab15 effector protein; Regulates transferrin receptor recycling from the endocytic recycling compartment."},{"id":"ENSMUSP00000063670","abundance":0.0005,"rank":17312,"name":"Gpr17","annotation":"Uracil nucleotide/cysteinyl leukotriene receptor; Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia (By similarity)."},{"id":"ENSMUSP00000101428","abundance":0.0005,"rank":17313,"name":"Htr6","annotation":"5-hydroxytryptamine receptor 6; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity. Is an activator of TOR signaling."},{"id":"ENSMUSP00000015723","abundance":0.0005,"rank":17314,"name":"Nkx2-5","annotation":"Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4. Binds to the core DNA motif of NPPA promoter. It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B. Together with PBX1, it is required for spleen development through a mechanism that involves CDKN2B repression."},{"id":"ENSMUSP00000144496","abundance":0.0005,"rank":17315,"name":"Tmem270","annotation":"Transmembrane protein 270."},{"id":"ENSMUSP00000024840","abundance":0.0005,"rank":17316,"name":"Arhgap28","annotation":"Rho GTPase-activating protein 28; GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state."},{"id":"ENSMUSP00000040920","abundance":0.0005,"rank":17317,"name":"Hoxa11","annotation":"Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis."},{"id":"ENSMUSP00000117898","abundance":0.0005,"rank":17318,"name":"Odam","annotation":"Odontogenic ameloblast-associated protein; Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface."},{"id":"ENSMUSP00000022195","abundance":0.0005,"rank":17319,"name":"Otp","annotation":"Homeobox protein orthopedia; Involved in the specification of hypothalamic neuroendocrine cells. Specifically required for the specification of diencephalic dopaminergic neurons of the A11 group."},{"id":"ENSMUSP00000020287","abundance":0.0005,"rank":17320,"name":"Npffr1","annotation":"Neuropeptide FF receptor 1; Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000077119","abundance":0.0005,"rank":17321,"name":"Fam71d","annotation":"Family with sequence similarity 71, member D."},{"id":"ENSMUSP00000028302","abundance":0.0005,"rank":17322,"name":"Lhx3","annotation":"LIM/homeobox protein Lhx3; Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pou1f1/Pit-1."},{"id":"ENSMUSP00000068471","abundance":0.0005,"rank":17323,"name":"Ldlrad4","annotation":"Low-density lipoprotein receptor class A domain-containing protein 4; Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription.  [...] "},{"id":"ENSMUSP00000051177","abundance":0.0005,"rank":17324,"name":"Iqub","annotation":"IQ and ubiquitin-like domain-containing protein; May play roles in cilia formation and/or maintenance."},{"id":"ENSMUSP00000046999","abundance":0.0005,"rank":17325,"name":"Hand1","annotation":"Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis. Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box). Acts as a transcriptional repressor of SOX15. In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity)."},{"id":"ENSMUSP00000052177","abundance":0.0004,"rank":17326,"name":"Lrrc28","annotation":"Leucine-rich repeat-containing protein 28."},{"id":"ENSMUSP00000101768","abundance":0.0004,"rank":17327,"name":"Csf3r","annotation":"Granulocyte colony-stimulating factor receptor; Receptor for granulocyte colony-stimulating factor (CSF3). In addition it may function in some adhesion or recognition events at the cell surface."},{"id":"ENSMUSP00000067632","abundance":0.0004,"rank":17328,"name":"Gabrg3","annotation":"Gamma-aminobutyric acid receptor subunit gamma-3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel."},{"id":"ENSMUSP00000007250","abundance":0.0004,"rank":17329,"name":"Msh5","annotation":"MutS protein homolog 5; Involved in DNA mismatch repair and meiotic recombination processes. Facilitates crossovers between homologs during meiosis (By similarity); Belongs to the DNA mismatch repair MutS family."},{"id":"ENSMUSP00000117891","abundance":0.0004,"rank":17330,"name":"Wt1","annotation":"Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'- GCG(T/G)GGGCG-3' (By similarity). Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform- specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism o [...] "},{"id":"ENSMUSP00000127457","abundance":0.0004,"rank":17331,"name":"Prr22","annotation":"Proline-rich 22."},{"id":"ENSMUSP00000103366","abundance":0.0004,"rank":17332,"name":"Sphk2","annotation":"Sphingosine kinase 2; Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-dihydrosphingosine, D- erythro-sphingosine and L-threo-dihydrosphingosine. Binds phosphoinositides. In contrast to prosurvival SPHK1, has a positive effect on intracellular ceramide levels, inhibits cells growth and enhances apoptosis. In mitochondria, is important for cytochrome-c oxidase assembly and mitochondrial respiration. The SPP produced in mitochondria binds PHB2 and modulates the regulat [...] "},{"id":"ENSMUSP00000119447","abundance":0.0004,"rank":17333,"name":"Slc26a2","annotation":"Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation."},{"id":"ENSMUSP00000095948","abundance":0.0004,"rank":17334,"name":"Prss44","annotation":"Serine protease 44; Belongs to the peptidase S1 family."},{"id":"ENSMUSP00000030925","abundance":0.0004,"rank":17335,"name":"Gabrd","annotation":"Gamma-aminobutyric acid receptor subunit delta; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel."},{"id":"ENSMUSP00000134568","abundance":0.0004,"rank":17336,"name":"Abhd12b","annotation":"Abhydrolase domain-containing 12B."},{"id":"ENSMUSP00000159074","abundance":0.0004,"rank":17337,"name":"C5ar2","annotation":"C5a anaphylatoxin chemotactic receptor 2; Receptor for the chemotactic and inflammatory C3a, C4a and C5a anaphylatoxin peptides and also for their dearginated forms ASP/C3adesArg, C4adesArg and C5adesArg respectively. Couples weakly to G(i)-mediated signaling pathways (By similarity); Belongs to the G-protein coupled receptor 1 family."},{"id":"ENSMUSP00000072531","abundance":0.0004,"rank":17338,"name":"Ms4a10","annotation":"Membrane-spanning 4-domains subfamily A member 10; May be involved in signal transduction as a component of a multimeric receptor complex; Belongs to the MS4A family."},{"id":"ENSMUSP00000109098","abundance":0.0004,"rank":17339,"name":"Prdm12","annotation":"PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation."},{"id":"ENSMUSP00000044833","abundance":0.0003,"rank":17340,"name":"Bicral","annotation":"BRD4-interacting chromatin-remodeling complex-associated protein-like; Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP- dependent manner."},{"id":"ENSMUSP00000102686","abundance":0.0003,"rank":17341,"name":"Gm12695","annotation":"Uncharacterized protein C1orf87 homolog."},{"id":"ENSMUSP00000035727","abundance":0.0003,"rank":17342,"name":"Mfsd9","annotation":"Major facilitator superfamily domain-containing protein 9."},{"id":"ENSMUSP00000135500","abundance":0.0003,"rank":17343,"name":"Ebf2","annotation":"Transcription factor COE2; Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'- ATTCCCNNGGGAATT-3'."},{"id":"ENSMUSP00000101947","abundance":0.0003,"rank":17344,"name":"Asphd1","annotation":"Aspartate beta-hydroxylase domain-containing protein 1; Belongs to the aspartyl/asparaginyl beta-hydroxylase family."},{"id":"ENSMUSP00000079660","abundance":0.0003,"rank":17345,"name":"Gm8882","annotation":"Predicted gene 8882."},{"id":"ENSMUSP00000040859","abundance":0.0003,"rank":17346,"name":"Tmc1","annotation":"Transmembrane channel-like protein 1; Probable ion channel required for the normal function of cochlear hair cells; Belongs to the TMC family."},{"id":"ENSMUSP00000061100","abundance":0.0003,"rank":17347,"name":"Tmem130","annotation":"Transmembrane protein 130."},{"id":"ENSMUSP00000028515","abundance":0.0003,"rank":17348,"name":"Chrna1","annotation":"Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane."},{"id":"ENSMUSP00000156061","abundance":0.0003,"rank":17349,"name":"Tbx1","annotation":"T-box transcription factor TBX1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries."},{"id":"ENSMUSP00000155225","abundance":0.0003,"rank":17350,"name":"Nr4a1","annotation":"Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury ; Belongs to the nuclear hormone receptor family. NR4 subfamily."},{"id":"ENSMUSP00000074201","abundance":0.0003,"rank":17351,"name":"Brinp3","annotation":"BMP/retinoic acid-inducible neural-specific protein 3; Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development. Belongs to the BRINP family."},{"id":"ENSMUSP00000158581","abundance":0.0003,"rank":17352,"name":"Prr33","annotation":"Proline-rich protein 33."},{"id":"ENSMUSP00000109036","abundance":0.0003,"rank":17353,"name":"Zfp711","annotation":"Zinc finger protein 711; Transcription regulator required for brain development. Probably acts as a transcription factor that binds to the promoter of target genes and recruits PHF8 histone demethylase, leading to activate expression of genes involved in neuron development, such as KDM5C (By similarity)."},{"id":"ENSMUSP00000105820","abundance":0.0002,"rank":17354,"name":"Gcnt2","annotation":"N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; Branching enzyme that converts linear into branched poly-N- acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells; Belongs to the glycosyltransferase 14 family."},{"id":"ENSMUSP00000079864","abundance":0.0002,"rank":17355,"name":"Entpd7","annotation":"Ectonucleoside triphosphate diphosphohydrolase 7; Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP (By similarity)."},{"id":"ENSMUSP00000049460","abundance":0.0002,"rank":17356,"name":"Plekhh1","annotation":"Pleckstrin homology domain-containing family H member 1."},{"id":"ENSMUSP00000145308","abundance":0.0002,"rank":17357,"name":"Tatdn2","annotation":"TatD DNase domain-containing 2."},{"id":"ENSMUSP00000028232","abundance":0.0002,"rank":17358,"name":"Phf19","annotation":"PHD finger protein 19; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem c [...] "},{"id":"ENSMUSP00000030948","abundance":0.0002,"rank":17359,"name":"Dvl1","annotation":"Segment polarity protein dishevelled homolog DVL-1; Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ). Belongs [...] "},{"id":"ENSMUSP00000091885","abundance":0.0002,"rank":17360,"name":"Lrrc43","annotation":"Leucine-rich repeat-containing protein 43."},{"id":"ENSMUSP00000027405","abundance":0.0002,"rank":17361,"name":"Slc23a3","annotation":"Solute carrier family 23 member 3."},{"id":"ENSMUSP00000112570","abundance":0.0002,"rank":17362,"name":"Ddr1","annotation":"Epithelial discoidin domain-containing receptor 1; Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing, but also tu [...] "},{"id":"ENSMUSP00000077390","abundance":0.0002,"rank":17363,"name":"Gm4787","annotation":"Predicted gene, EG214321."},{"id":"ENSMUSP00000033004","abundance":0.0002,"rank":17364,"name":"Il4ra","annotation":"Soluble interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2."},{"id":"ENSMUSP00000079041","abundance":0.0002,"rank":17365,"name":"Adamts16","annotation":"A disintegrin and metalloproteinase with thrombospondin motifs 16."},{"id":"ENSMUSP00000081284","abundance":0.0001,"rank":17366,"name":"Spocd1","annotation":"SPOC domain-containing 1."},{"id":"ENSMUSP00000009667","abundance":0.0001,"rank":17367,"name":"Ush1c","annotation":"Harmonin; Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal development and maintenance of cochlear hair cell bundles. As part of the intermicrovillar adhesion complex/IMAC plays a role in brush border differentiation, controlling microvilli organization and length. Probably plays a central regulatory role in the assembly of the complex, recruiting CDHR2, CDHR5 and MYO7B to the microvilli tips."},{"id":"ENSMUSP00000123404","abundance":0.0001,"rank":17368,"name":"Vinac1","annotation":"Vinculin/alpha-catenin family member 1."},{"id":"ENSMUSP00000154494","abundance":0.0001,"rank":17369,"name":"Mcf2","annotation":"Mcf.2-transforming sequence."},{"id":"ENSMUSP00000153646","abundance":0.0001,"rank":17370,"name":"Gm29776","annotation":"Leishmanolysin-like peptidase."},{"id":"ENSMUSP00000104293","abundance":0.0001,"rank":17371,"name":"Nlrp12","annotation":"NACHT, LRR and PYD domains-containing protein 12; Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non- canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125 [...] "},{"id":"ENSMUSP00000130530","abundance":0.0001,"rank":17372,"name":"Adcy4","annotation":"Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family."},{"id":"ENSMUSP00000080938","abundance":0.0001,"rank":17373,"name":"Cr2","annotation":"Complement receptor type 2; Receptor for complement C3d and for HNRNPU. Participates in B lymphocytes activation; Belongs to the receptors of complement activation (RCA) family."},{"id":"ENSMUSP00000085187","abundance":0.00009,"rank":17374,"name":"Nexmif","annotation":"Neurite extension and migration factor; Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1)."},{"id":"ENSMUSP00000129467","abundance":0.00008,"rank":17375,"name":"Otogl","annotation":"Otogelin-like protein."},{"id":"ENSMUSP00000020045","abundance":0.00006,"rank":17376,"name":"Ros1","annotation":"Proto-oncogene tyrosine-protein kinase ROS; Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation [...] "}]